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Sequence AKAP13.bAug05
TGAGTTGAAGTGGGGGAAATAGAGGAGTAAATCATTTCACGATGTGTGGTTAAGTGCTGCAGCTCAGGTAACCACCAGTACACAGAGGAAGGGCGGTTTCTGGAGACAGGGCGGAGAGGAGACCGTGGGTGGGCATTTCCCAGAGCAGCCTCTGCCAGCCACCCTACTTTGATCACTTTGCCGCCGAGCAGCAGCGGCGG
TCAACCTCAGCCTCCCTTAGCAACCTGAGTGCCCCGTCCAGGAGCCTTACTATTGGTCTCATGCAGCGAGATGGGCAGTTCTGCCGTGCAATCCCAGCTC
GCAGTTCTTGCTCCGCGTGTACTCACGGGAGGACTCGCAGGCGTTACCGCCTTCCCGCGTGCCCCGCCCACCCTCCCGAGCGTCTTTCGGCGCATGCGCG
GACTGGAGCTGTGTGCAGGGCCAGCGCGGAGCCCGAGCAGCCGCGGTGAAGCGCCTGTGCTCTGCCGAGACTGCCGTGCCCATTGCTCGCCTCGGTCGCC
GCCGCTTTAGCCGCCTCCGGGGGAGCGGCCGCCTATTGTCTTTCTCCGCGGCGAAGGTGAAGAGTTGTCCCAGCTCGGCCCGCGGGGGAGCCCCGGGAGC
CGCACGTGTCCTGGGTCATGAAACTTAATCCACAGCAAGCTCCCTTATATGGTGATTGTGTTGTTACAGTGCTGCTTGCTGAAGAGGACAAAGCTGAAGA
TGATGTAGTGTTTTACTTGGTATTTTTGGGTTCCACCCTCCGTCACTGTACAAGTACTCGGAAGGTCAGTTCTGATACATTGGAGACCATTGCTCCTGGT
CATGATTGTTGTGAAACAGTGAAGGTGCAGCTCTGTGCTTCCAAAGAGGGCCTTCCCGTGTTTGTGGTGGCTGAAGAAGACTTTCATTTCGTCCAGGATG
AAGCGTATGATGCAGCTCAATTCCTAGCAACCAGTGCTGGAAATCAGCAGGCTTTGAACTTTACCCGTTTTCTTGACCAGTCAGGACCCCCATCTGGGGA
TGTGAATTCCCTTGATAAGAAGTTGGTGCTGGCATTCAGGCACCTGAAGCTGCCCACGGAGTGGAATGTATTGGGGACAGATCAGAGTTTGCATGATGCT
GGCCCGCGAGAGACATTGATGCATTTTGCTGTGCGGCTGGGACTGCTGAGGTTGACGTGGTTCCTGTTGCAGAAGCCAGGTGGCCGCGGAGCTCTCAGTA
TCCACAACCAGGAAGGGGCGACGCCTGTGAGCTTGGCCTTGGAGCGAGGCTATCACAAGCTGCACCAGCTTCTAACCGAGGAGAATGCTGGAGAACCAGA
CTCCTGGAGCAGTTTATCCTATGAAATACCGTATGGAGACTGTTCTGTGAGGCATCATCGAGAGTTGGACATCTATACATTAACCTCTGAGTCTGATTCA
CATCATGAACACCCATTTCCTGGAGACGGTTGCACTGGACCAATTTTTAAACTTATGAACATCCAACAGCAACTAATGAAAACAAACCTCAAGCAGATGG
ACAGTCTTATGCCCTTAATGATGACAGCACAGGATCCTTCCAGTGCCCCAGAGACAGATGGCCAGTTTCTTCCCTGTGCACCGGAGCCCACGGACCCTCA
GCGACTTTCTTCTTCTGAAGAGACTGAGAGCACTCAGTGCTGCCCAGGGAGCCCTGTTGCACAGACTGAAAGTCCCTGTGATTTGTCAAGCATAGTTGAG
GAGGAGAATACAGACCGTTCCTGTAGGAAGAAAAATAAAGGCGTGGAAAGAAAAGGGGAAGAGGTGGAGCCAGCACCTATTGTGGACTCTGGAACTGTAT
CTGATCAAGACAGCTGCCTTCAGAGCTTGCCTGATTGTGGAGTAAAGGGCACGGAAGGCCTTTCGTCCTGTGGAAACAGAAATGAAGAAACTGGAACAAA
ATCTTCTGGAATGCCCACAGACCAGGAGTCCCTGAGCAGTGGAGATGCTGTGCTTCAGAGAGACTTGGTCATGGAGCCAGGCACAGCCCAGTATTCCTCT
GGAGGTGAACTGGGAGGCATTTCAACAACAAATGTCAGTACCCCAGACACTGCAGGGGAAATGGAACATGGGCTCATGAACCCAGATGCCACTGTTTGGA
AGAATGTGCTTCAGGGAGGGGAAAGTACAAAGGAAAGATTTGAGAACTCTAATATTGGCACAGCTGGAGCCTCTGACGTGCACGTCACAAGTAAGCCTGT
GGATAAAATCAGTGTTCCAAACTGTGCCCCTGCTGCCAGTTCCCTGGATGGTAACAAACCTGCTGAGTCTTCACTTGCATTTAGTAATGAAGAAACCTCC
ACTGAAAAAACAGCAGAAACGGAAACTTCACGAAGTCGTGAGGAGAGTGCTGATGCTCCAGTAGATCAGAATTCTGTGGTGATTCCAGCTGCTGCAAAAG
ACAAGATTTCAGATGGATTAGAACCTTATACTCTCTTAGCAGCAGGCATAGGTGAGGCAATGTCACCCTCAGATTTAGCCCTTCTTGGGCTGGAAGAAGA
TGTAATGCCACACCAGAACTCAGAAACAAATTCATCTCATGCTCAAAGCCAAAAGGGCAAATCCTCACCCATTTGTTCTACAACTGGAGACGATAAACTT
TGTGCAGACTCTGCATGTCAACAGAACACAGTGACTTCTAGTGGCGATTTGGTTGCAAAACTGTGTGATAACATAGTTAGCGAGTCCGAAAGCACCACAG
CAAGGCAACCCAGCTCACAAGATCCACCCGATGCCTCCCACTGTGAAGACCCACAGGCTCATACAGTCACCTCTGACCCTGTAAGGGATACCCAGGAACG
TGCGGATTTTTGTCCTTTCAAAGTGGTGGATAACAAAGGCCAACGAAAAGATGTGAAACTAGATAAACCTTTAACAAATATGCTTGAGGTGGTTTCACAT
CCACATCCAGTTGTCCCTAAAATGGAGAAAGAACTGGTGCCAGACCAGGCAGTAATATCAGACAGTACTTTCTCTCTGGCAAACAGTCCAGGCAGTGAAT
CAGTAACCAAGGATGACGCACTTTCTTTTGTCCCCTCCCAGAAAGAAAAGGGAACAGCAACTCCTGAACTACATACAGCTACAGATTATAGAGATGGCCC
AGATGGAAATTCGAATGAGCCTGATACGCGGCCACTAGAAGACAGGGCAGTAGGCCTGTCCACATCCTCCACTGCTGCAGAGCTTCAGCACGGGATGGGG
AATACCAGTCTCACAGGACTTGGTGGAGAGCATGAGGGTCCCGCCCCTCCAGCAATCCCAGAAGCTCTGAATATCAAGGGGAACACTGACTCTTCCCTGC
AAAGTGTGGGTAAGGCCACTTTGGCTTTAGATTCAGTTTTGACTGAAGAAGGAAAACTTCTGGTGGTTTCAGAAAGCTCTGCAGCTCAGGAACAAGATAA
GGATAAAGCGGTGACCTGTTCCTCTATTAAGGAAAATGCTCTCTCTTCAGGAACTTTGCAGGAAGAGCAGAGAACACCACCTCCTGGACAAGATACTCAA
CAATTTCATGAAAAATCAATCTCAGCTGACTGTGCCAAGGACAAAGCACTTCAGCTAAGTAATTCACCGGGTGCATCCTCTGCCTTTCTTAAGGCAGAAA
CTGAACATAACAAGGAAGTGGCCCCACAAGTCTCACTGCTGACTCAAGGTGGGGCTGCCCAGAGCCTGGTGCCACCAGGAGCAAGTCTGGCCACAGAGTC
AAGGCAGGAAGCCTTGGGGGCAGAGCACAACAGCTCCGCTCTGTTGCCATGTCTGTTGCCAGATGGGTCTGATGGGTCCGATGCTCTTAACTGCAGTCAG
CCTTCTCCTCTGGATGTTGGAGTGAAGAACACTCAATCCCAGGGAAAAACTAGTGCCTGTGAGGTGAGTGGAGATGTGACGGTGGATGTTACAGGGGTTA
ATGCTCTACAAGGTATGGCTGAGCCCAGAAGAGAGAATATATCACACAACACCCAAGACATCCTGATTCCAAACGTCTTGTTGAGCCAAGAGAAGAATGC
CGTTCTAGGTTTGCCAGTGGCTCTACAGGACAAAGCTGTGACTGACCCACAGGGAGTTGGAACCCCAGAGATGATACCTCTTGATTGGGAGAAAGGGAAG
CTGGAGGGAGCAGACCACAGCTGTACCATGGGTGACGCTGAGGAAGCCCAAATAGACGATGAAGCACATCCTGTCCTACTGCAGCCTGTTGCCAAGGAGC
TCCCCACAGACATGGAGCTCTCAGCCCATGATGATGGGGCCCCAGCTGGTGTGAGGGAAGTCATGCGAGCCCCGCCTTCAGGCAGGGAAAGGAGCACTCC
CTCTCTACCTTGCATGGTCTCTGCCCAGGACGCACCTCTGCCTAAGGGGGCAGACTTGATAGAGGAGGCTGCCAGCCGTATAGTGGATGCTGTCATCGAA
CAAGTCAAGGCCGCTGGAGCACTGCTTACTGAGGGGGAGGCCTGTCACATGTCACTGTCCAGCCCTGAGTTGGGTCCTCTCACTAAAGGACTAGAGAGTG
CTTTTACAGAAAAAGTGAGTACTTTCCCACCTGGGGAGAGCCTACCAATGGGCAGTACTCCTGAGGAAGCCACGGGGAGCCTTGCAGGATGTTTTGCTGG
AAGGGAGGAGCCAGAGAAGATCATTTTACCTGTCCAGGGGCCTGAGCCAGCAGCAGAAATGCCAGACGTGAAAGCTGAAGATGAAGTGGATTTTAGAGCA
AGTTCAATTTCTGAAGAAGTGGCTGTAGGGAGCATAGCTGCTACACTGAAGATGAAGCAAGGCCCAATGACCCAGGCGATAAACCGAGAAAACTGGTGTA
CAATAGAGCCATGCCCTGATGCAGCATCTCTTCTGGCTTCCAAGCAGAGCCCAGAATGTGAGAACTTCCTGGATGTTGGACTGGGCAGAGAGTGTACCTC
AAAACAAGGTGTACTTAAAAGAGAATCTGGGAGTGATTCTGACCTCTTTCACTCACCCAGTGATGACATGGACAGCATCATCTTCCCAAAGCCAGAGGAA
GAGCATTTGGCCTGTGATATCACCGGATCCAGTTCATCCACCGATGACACGGCTTCACTGGACCGACATTCTTCTCATGGCAGTGATGTGTCTCTCTCCC
AGATTTTAAAGCCAAACAGGTCAAGAGATCGGCAAAGCCTTGATGGATTCTACAGCCATGGGATGGGAGCTGAGGGTCGAGAAAGTGAGAGTGAGCCTGC
TGACCCAGGCGACGTGGAGGAGGAGGAGATGGACAGTATCACTGAAGTGCCTGCAAACTGCTCTGTCCTAAGGAGCTCCATGCGCTCTCTTTCTCCCTTC
CGGAGGCACAGCTGGGGGCCTGGGAAAAATGCAGCCAGCGATGCAGAAATGAACCACCGGAGTTCAATGCGAGTTCTTGGGGATGTTGTCAGGAGACCTC
CCATTCATAGGAGAAGTTTCAGTCTAGAAGGCTTGACAGGAGGAGCTGGTGTCGGAAACAAGCCATCCTCATCTCTAGAAGTAAGCTCTGCAAATGCCGA
AGAGCTCAGACACCCATTCAGTGGTGAGGAACGGGTTGACTCTTTGGTGTCACTTTCAGAAGAGGATCTGGAGTCAGACCAGAGAGAACATAGGATGTTT
GATCAGCAGATATGTCACAGATCTAAGCAGCAGGGATTTAATTACTGTACATCAGCCATTTCCTCTCCATTGACAAAATCCATCTCATTAATGACAATCA
GCCATCCTGGATTGGACAATTCACGGCCCTTCCACAGTACCTTCCACAATACCAGTGCTAATCTGACTGAGAGTATAACAGAAGAGAACTATAATTTCCT
GCCACATAGCCCCTCCAAGAAAGATTCTGAATGGAAGAGTGGAACAAAAGTCAGTCGTACATTCAGCTACATCAAGAATAAAATGTCTAGCAGCAAGAAG
AGCAAAGAAAAGGAAAAAGAAAAAGATAAGATTAAGGAGAAGGAGAAAGATTCTAAAGACAAGGAGAAAGATAAGAAGACTGTCAACGGGCACACTTTCA
GTTCCATTCCTGTTGTGGGTCCCATCAGCTGTAGCCAGTGTATGAAGCCCTTCACCAACAAAGATGCCTATACTTGTGCAAATTGCAGTGCTTTTGTCCA
CAAAGGCTGCCGAGAAAGTCTAGCCTCCTGTGCAAAGGTCAAAATGAAGCAGCCCAAAGGGAGCCTTCAGGCACATGACACATCATCACTGCCCACGGTC
ATTATGAGAAACAAGCCCTCACAGCCCAAGGAGCGTCCTCGGTCCGCAGTCCTCCTGGTGGATGAAACCGCTACCACCCCAATATTTGCCAATAGACGAT
CCCAGCAGAGTGTCTCGCTCTCCAAAAGTGTCTCCATACAGAACATTACTGGAGTTGGCAATGATGAGAACATGTCAAACACCTGGAAATTCCTGTCTCA
TTCAACAGACTCACTAAATAAAATCAGCAAGGTCAATGAGTCAACAGAATCACTTACTGATGAGGGAGTAGGTACAGACATGAATGAAGGACAACTACTG
GGAGACTTTGAGATTGAGTCCAAACAGCTGGAAGCAGAGTCTTGGAGTCGGATAATAGACAGCAAGTTTCTAAAACAGCAAAAGAAAGATGTGGTCAAAC
GGCAAGAAGTAATATATGAGTTGATGCAGACAGAGTTTCATCATGTCCGCACTCTCAAGATCATGAGTGGTGTGTACAGCCAGGGGATGATGGCGGATCT
GCTTTTTGAGCAGCAGATGGTAGAAAAGCTGTTCCCCTGTTTGGATGAGCTGATCAGTATCCATAGCCAATTCTTCCAGAGGATTCTGGAGCGGAAGAAG
GAGTCTCTGGTGGATAAAAGTGAAAAGAACTTTCTCATCAAGAGGATAGGGGATGTGCTTGTAAATCAGTTTTCAGGTGAGAATGCAGAACGTTTAAAGA
AGACATATGGCAAGTTTTGTGGGCAACATAACCAGTCTGTAAACTACTTCAAAGACCTTTATGCCAAGGATAAGCGTTTTCAAGCCTTTGTAAAGAAGAA
GATGAGCAGTTCAGTTGTTAGAAGGCTTGGAATTCCAGAGTGCATATTGCTTGTAACTCAGCGGATTACCAAGTACCCAGTTTTATTCCAAAGAATATTG
CAGTGTACCAAAGACAATGAAGTGGAGCAGGAAGATCTAGCACAGTCCTTGAGCCTGGTGAAGGATGTGATTGGAGCTGTAGACAGCAAAGTGGCAAGTT
ATGAAAAGAAAGTGCGTCTCAATGAGATTTATACAAAGACAGATAGCAAGTCAATCATGAGGATGAAGAGTGGTCAGATGTTTGCCAAGGAAGATTTGAA
ACGGAAGAAGCTTGTACGTGATGGGAGTGTGTTTCTGAAGAATGCAGCAGGAAGGTTGAAAGAGGTTCAAGCAGTTCTTCTCACTGACATTTTAGTTTTC
CTTCAAGAAAAAGACCAGAAGTACATCTTTGCATCATTGGACCAGAAGTCAACAGTGATCTCTTTAAAGAAGCTGATTGTGAGAGAAGTGGCACATGAGG
AGAAAGGTTTATTCCTGATCAGCATGGGGATGACAGATCCAGAGATGGTAGAAGTCCATGCCAGCTCCAAAGAGGAACGAAACAGCTGGATTCAGATCAT
TCAGGACACAATCAACACCCTGAACAGAGATGAAGATGAAGGAATTCCTAGTGAGAATGAGGAAGAAAAGAAAATGTTGGACACCAGAGCCCGAGAATTA
AAAGAACAACTTCACCAGAAGGACCAAAAAATCCTACTCTTGTTGGAAGAGAAGGAGATGATTTTCCGGGACATGGCTGAGTGCAGCACCCCTCTCCCAG
AGGATTGCTCCCCAACACATAGCCCTAGAGTTCTCTTCCGCTCCAACACAGAAGAGGCTCTCAAAGGAGGACCTTTAATGAAAAGTGCAATAAATGAGGT
GGAGATCCTTCAGGGTTTGGTGAGTGGAAATCTGGGAGGCACACTTGGGCCGACTGTCAGCAGCCCCATTGAGCAAGATGTGGTCGGTCCCGTTTCCCTG
CCCCGGAGAGCAGAGACCTTTGGAGGATTTGACAGCCATCAGATGAATGCTTCAAAAGGAGGCGAGAAGGAAGAGGGAGATGATGGCCAAGATCTTAGGA
GAACGGAATCAGATAGTGGCCTAAAAAAGGGTGGAAATGCTAACCTGGTATTTATGCTTAAAAGAAACAGTGAGCAGGTTGTCCAGAGCGTTGTTCATCT
CTACGAGCTCCTCAGCGCTCTGCAGGGTGTGGTGCTGCAGCAGGACAGCTACATTGAGGACCAGAAACTGGTGCTGAGCGAGAGGGCGCTCACTCGCAGC
TTGTCCCGCCCGAGCTCCCTCATTGAGCAGGAGAAGCAGCGCAGCCTGGAGAAGCAGCGCCAGGACCTGGCCAACCTGCAGAAGCAGCAGGCCCAGTACC
TCGAGGAGAAGCGCAGGCGCGAGCGTGAGTGGGAAGCTCGTGAGAGGGAGCTGCGGGAGCGGGAGGCCCTCCTGGCCCAGCGCGAGGAGGAGGTGCAGCA
GGGGCAGCAGGACCTGGAAAAGGAGCGGGAGGAGCTCCAGCAGAAGAAGGGCACATACCAGTATGACCTGGAGCGACTGCGTGCTGCCCAGAAACAGCTT
GAGAGGGAACAGGAGCAGCTGCGCCGGGAGGCAGAGCGGCTCAGCCAGCGGCAGACAGAACGGGACCTGTGTCAGGTTTCCCATCCACATACCAAGCTGA
TGAGGATCCCATCGTTCTTCCCCAGTCCTGAGGAGCCCCCCTCGCCATCTGCACCTTCCATAGCCAAATCAGGGTCATTGGACTCAGAACTTTCAGTGTC
CCCAAAAAGGAACAGCATCTCTCGGACACACAAAGATAAGGGGCCTTTTCACATACTGAGTTCAACCAGCCAGACAAACAAAGGACCAGAAGGGCAGAGC
CAGGCCCCTGCGTCCACCTCTGCCTCTACCCGCCTGTTTGGGTTAACAAAGCCAAAGGAAAAGAAGGAGAAAAAAAAGAAGAACAAAACCAGCCGCTCTC
AGCCCGGTGATGGTCCCGCGTCAGAAGTATCAGCAGAGGGTGAAGAGATCTTCTGCTGACCCTCTTCCTCTCTGCTGAGGCAGCTGCCTCCTGATCCTGG
CCAGCCCACCTCTCCTGCTGTCCCCGCGTGCACAAGTCTCTTACACTGGACGCCCACTGCTCCTCAGCGTCCAGTCCTCCTGGGCGGCCCCAGGTCCTGG
ACAATAAGCAACAGATGATATTGAGTGTCGGGTGGGGAAGGAGGCCCAGACTCTGCTTCGGCCATGATTTGTGACTGCCCAGGACTCTCAGGTTGGGCTG
GCCCTACTCAGGATTACACTGAAAGTAATGGCCTCGTAAGTACAGGTGATGGTTTTGGACACGTCAGGAATTCCTAAAGGCTGAAAGAGTGTATCCAAGT
AAGGTCTGAACCTCCGAATGCCTTTTATTTGGGGGAACACAAAACCAAACAGCAGATGTTTTGGACTTGATCTGTGTACGTACATGGGGACCTGTCTGCA
TATACACACGGGGAATGCCAGAAGAAGGCCCAGTCTGCACCAGGCGTCTGGTCAACTTAGCACAAGGGCAGTGCCTGGACGGACCCGGAGCCCCCGCATA
TCAGCAGTTCACCCAGTACTCCTCAGAGACTGGTTTCCCTCTAAACCCATCCCGGGCACATACCACCCGTGTTTTGCATGTATTTCTCATTTCATTTTAG
GGATGACAAACATTTGTGAAACCAGTGAGAGAAGGCTTGATGTGTATAAAAGACGTGATGTGCACCACCTCGATCTCGGTGTTTCAGGCACTAAAGCAAC
AAAACAACCCATAGTATCTCATTCTGTCATCAGATCCAGAAGAAATATCCTGGTTTTCCAGCATGTTTACCCACATGTTTTGGCCATGGATAAAGTGAAG
AGGCCTACTCACCATTATCCCTGCAGCGTGACACCTTTTGATTGTCACTGACCACTCAGAAGGGGCCACGGCCTCCTGGCTGTGTTCCTGAGCCCCCGTC
GTGCCTCTCCCAGACAGCAGCTGTCTGGCCCTTGCTGGGTGAGGGCACACCACTGCCAGGGGTCAGCCTCGCACCCAGGCCAGGCAGAAGCTGTGCTCTG
AAGCTAGGACAGCTGGCTGAGAAGTGGGTTCAGGCGAAGGGTGAAGCCATGTGTAGCAGTTCCTGCCAGTGCAGATCTGGAGAGGAGCTGGCCCGGAAGG
CGTGGTTGTGAAAGCGCCCTTCTTATGTTAGGAGGCCTTGGCAAAATTGGATTTCTTCAAAAATACATGTAAAGGTCTGTTGTTGAATTGTACTCTGCCC
CTGGAAGCAGATACAGATGGCTGCCTGCTGCTCGGCTTTGCTTTTGCTTTTCCCACCGTGTTTTCATCTTTGTTCACTTGAGGCTTTCCCCAGCTGGTGT
GTGCAGGACAGTTCATGGTAATGTTGCCCTCTGAGGCCCCGTACACCAGAAGGGAGGCCCTGGAAAATTTTGTGCTTCCAACGTGGCCTTCAATTCTTGC
TTTTTTGCCCCTCGGAAGCATGGGGCTTTTGAGCACACTTAAAAAAAGAAAAATCTGTAACTTGGTGCTTATTGATGAATTGCAAGCTGGCCTTGCAGAT
GGAGATATTTATCTTTCAGTTTATTTGAAAGAGGTCTGGTTTAAAATTTGTAGCCTACATTTGTTTTATTTATTGTATTTGTGTGTTTGTGTTTGTTTTT
TTTTAAGGGTGAGCCAGGTCTAGCCCAACAGTCTAAACTATCCAGTCAATACCGAGTGAAGTGGCAGCCAGCACTGTTCACTCTGTGTCTTTTGAAGTGC
CTTGAAGGCCCAGATGAAATTTTAAAGGGAGGGGGTCCATGTCCTTCCCTCCCCCACCCCGCCTCATTCTTTAATCAAAGGATGTCTTCTCCCTTGTTTG
AGAATGAAGAAACTCGCCACCTCTGACCTACCTTTGCCTTTTTCTGTCATGGAGAATACTCACCCTTCAGAAACAGACCAAAGGCCAAAACCTGCTGATT
TTTCTATTGAAAATATGTCCCCTTGCAAAGACCCTAAACAAAAAGTTAAGTTTCTTTCTTTCACCTATTTGTACAACTCCAAGTTACAGCTGAATCTGTC
GTGACTTTCCTGAGATCTACCCGGGGCTTGGCTGTCTGTTCTGGGCACTGGCTCCGAGTTCCCCTCCTGGGATTTGCAGGAGGGCAGTACTGAACCTGCA
TTCTTCTCCTTGTAAATGTAGGCCGGGTGCCCCTGTTCTCCGGGTTTGGAACAATACGAGGTTGGTGCTGATGGGATTTACTTGCGTACGTGCTCTTCAC
AAAAACACCGTGGATGCTGAAGTTAGAGCACGTCGCCACAGAGCTTGACATCAATGTTAGAGGGTCTCTTACTCCCCGCCCAGCTGTGATGTTTCATCTG
CTTTGGTTGTTTTGGTGGTCTTTTTTAAAAATAGAGATTTCACATCTGCCCAGACCCCACTCAAAACGATTTGGTCAGGTTCTGGTTGGACAAGTTTAAA
ATCAAAGTAGTGCCCGGAATTCCCTCAAACCACCCAACTTCATCCAGGAATACAGTCTGCAGTGCAGCAACAGAACCGCTTACCAAGAACTGTGCTTACA
TACCTTTGTCATCTCTCTTCCCCCCTTGGAAGTTGTCCTCAGGGGGATTTGTTCCTGTCCTGGGGATTTACCTGGGATGGTGGCTGCCTGTGCTTTTGCT
CATGGCCTTGACAGTGCTCTAGTTGCTGGATCTAATGGCCTGTCTTGGTTTCTATCACATGAGAAGGGGTTGTTTTTTTGGGGTGACTCGGACTGAATTC
CCCATACTGTTTCCACGCCGGGACACCATGTTCTCCATCAAGCTAAAGAAATCACGTGCCTGAAACTGTGCTTAAGTTTTGGGGGAAAGATGGAGTTCCT
ATCCAGAGCCCCCAGATTTCCAGAATCGAGTGAGCTTCCTGGAAGGAGACTGCGTCTTCTCTCAATTCCAGTCATCTCAGTCGTTGTCGTTAGGTGACAT
GTGCACTTTAAATGCTCTCATCGGTTGGCTTCATTTTCAAGACAATCAAATGTATTGACTGTGTTTTCTTCTTAGAAAATGGAGAGGGTTAAAAACATGC
AAACTGCCACTTTCAACCTTTGCCAGTATTCCCTCTACCCCCGTGAGAGCTATCTGGGGGGAAGAATCCTTACCAAGGTTTTTTTGGAAAGGTACGAATC
TTAACTTTTTTCCCCTTCTGTGTCTCAGGGTAATACTATTCAGAGTCGCCCCTTTGCTCATTTTCTCCCGTATTTGTTACCTTCCTGAGGCCTCAGTATT
AGTCGTGAGCACAAAGTTTTGAGACCTTTGGCGTTGTTTCTTGATGTGGGAGGGGAGGTGTTAGTGCATGCAAGGGTTGAACTAGATAGACCCTGCCTTA
GTAGAGGGTGGGACTATAACCTTAGAGGCCAGAACTTGATCCAGAAGTTGCTGTCCACAGAAGTGCTTTCTATTTCATCATTTTTGTTTCTAGGGCTCTT
TTTCTGTAGCCAGGTCTTCCCAAGGATTTTAGTATTTGCATTGGAGTTGAGGTTTACTCTAATGATGGTGGCCCAGCTGTGCCCAGAGGACAGCCAGGCA
GGCCCTGGGAGGGAGTTTAGAAAGACAGTCCTGGTGAATGGGCTTCAAGTGGTCACAAAGAGGGTGGCTGTGAGGTGACCCCAGACACTGCAGAACGATG
TGCACCCTCTGCGTTTTGGATGTCCTTGGAATGTGGGAGCCTAGAAATAACCCTGTGGATGGAATTGGGGCAGCGGCTGCTGGAGATCTGTGTGCCTTGC
CTTCCTTCAGCAGGACCGTCTAGGTGCGCAGCCACCTATGGATGCGTCCCAGCCAGCCCCGTCGCTCTCGTCCATCCTCAGAGACAAAGAAGAGGGCAGG
GAGTTTGGGCTTGGTTTTGAACTTTCCTTTCAATGTAGCAAAGCATTCCTAGTTAACCAGAGCCTTGGAATCTACTGCCTGCTGGCCAGGCTTTAAAATG
AAAAGTGTTTTAATGCTGCCATAAAAGGGAGGCGGGGGGGAGGAAGGGAAAATAAAGGCATCTTTCCAAGTACTCATCTAATTTAATTGTCAAAAGATTG
ATAGGCCATGAATTACTTCTCCATCTCACTAAGGGTTAAAGGCGTGCAACCCCCCACTGGCTGTGTCCCCTGCCACCGAAGTGAGTGACCTGCCCTACAA
CCAGGTGGGACCACCTGTGCTGCAGTCCGGAGGGGCTTCTGCAGGAAGCACTCACCCCCCACACCTTCCCCGGCCTGAGCTTCCCCTACCTTTCGTCACC
ACCTGAGGGCATGAGCACAGGCCATGGGGCGTGCCTGGTGAGTCTGCCTGTGGTTCAGGCTTAGCCTGTGGTCTCCTGTGTGCTGCTGCCCGCATGGGAT
GCGCAGGGGAGGCGTGGGGATCCGCAGGAGGGTGGTTGGGATACACCGGATACCTCTGCTCTCATTGCTTGTTTGCAAATGCTCTATGGACATTTGTGTG
CTAAATCCTATTAAATAAAAAAGACGGGTTAAAACCCAGATGCTGTATATTCATTTGTAATTATGTATAAAGTGAAGCAGTTTTAAACTGTAAAGATTTT
TTTCAGTGTGTTTTCTCGAATTTTGCCACAACATACTGGCTTCGTATTTTATTTATCTTTCTTTCTAGTTACCAGCTTCAGACCCTTGTAAAGTCTCCCT
CAGCCCTTTCAAAAAATAATAAATTTCCTGTGAAGTTCTGG
- AKAP13-F1 (forward primer)
- AKAP13-R1 (reverse primer)
- Single exon skipping
Frame 0
*VEVGEIEE*IISRCVVKCCSSGNHQYTEEGRFLETGRRGDRGWAFPRAASASHPTLITLPPSSSGG
QPQPPLAT*VPRPGALLLVSCSEMGSSAVQSQL
AVLAPRVLTGGLAGVTAFPRAPPTLPSVFRRMR
GLELCAGPARSPSSRGEAPVLCRDCRAHCSPRSP
PL*PPPGERPPIVFLRGEGEELSQLGPRGSPGS
RTCPGS*NLIHSKLPYMVIVLLQCCLLKRTKLK
MM*CFTWYFWVPPSVTVQVLGRSVLIHWRPLLLV
MIVVKQ*RCSSVLPKRAFPCLWWLKKTFISSRM
KRMMQLNS*QPVLEISRL*TLPVFLTSQDPHLG
M*IPLIRSWCWHSGT*SCPRSGMYWGQIRVCMML
ARERH*CILLCGWDC*G*RGSCCRSQVAAELSV
STTRKGRRL*AWPWSEAITSCTSF*PRRMLENQ
TPGAVYPMKYRMETVL*GIIESWTSIH*PLSLIH
IMNTHFLETVALDQFLNL*TSNSN**KQTSSRW
TVLCP***QHRILPVPQRQMASFFPVHRSPRTL
SDFLLLKRLRALSAAQGALLHRLKVPVICQA*LR
RRIQTVPVGRKIKAWKEKGKRWSQHLLWTLELY
LIKTAAFRACLIVE*RARKAFRPVETEMKKLEQ
NLLECPQTRSP*AVEMLCFRETWSWSQAQPSIPL
EVNWEAFQQQMSVPQTLQGKWNMGS*TQMPLFG
RMCFREGKVQRKDLRTLILAQLEPLTCTSQVSL
WIKSVFQTVPLLPVPWMVTNLLSLHLHLVMKKPP
LKKQQKRKLHEVVRRVLMLQ*IRILW*FQLLQK
TRFQMD*NLILS*QQA*VRQCHPQI*PFLGWKK
M*CHTRTQKQIHLMLKAKRANPHPFVLQLETINF
VQTLHVNRTQ*LLVAIWLQNCVIT*LASPKAPQ
QGNPAHKIHPMPPTVKTHRLIQSPLTL*GIPRN
VRIFVLSKWWITKANEKM*N*INL*QICLRWFHI
HIQLSLKWRKNWCQTRQ*YQTVLSLWQTVQAVN
Q*PRMTHFLLSPPRKKREQQLLNYIQLQIIEMA
QMEIRMSLIRGH*KTGQ*ACPHPPLLQSFSTGWG
IPVSQDLVESMRVPPLQQSQKL*ISRGTLTLPC
KVWVRPLWL*IQF*LKKENFWWFQKALQLRNKI
RIKR*PVPLLRKMLSLQELCRKSREHHLLDKILN
NFMKNQSQLTVPRTKHFS*VIHRVHPLPFLRQK
LNITRKWPHKSHC*LKVGLPRAWCHQEQVWPQS
QGRKPWGQSTTAPLCCHVCCQMGLMGPMLLTAVS
LLLWMLE*RTLNPREKLVPVR*VEM*RWMLQGL
MLYKVWLSPEERIYHTTPKTS*FQTSC*AKRRM
PF*VCQWLYRTKL*LTHRELEPQR*YLLIGRKGS
WREQTTAVPWVTLRKPK*TMKHILSYCSLLPRS
SPQTWSSQPMMMGPQLV*GKSCEPRLQAGKGAL
PLYLAWSLPRTHLCLRGQT**RRLPAV*WMLSSN
KSRPLEHCLLRGRPVTCHCPALSWVLSLKD*RV
LLQKK*VLSHLGRAYQWAVLLRKPRGALQDVLL
EGRSQRRSFYLSRGLSQQQKCQT*KLKMKWILEQ
VQFLKKWL*GA*LLH*R*SKAQ*PRR*TEKTGV
Q*SHALMQHLFWLPSRAQNVRTSWMLDWAESVP
QNKVYLKENLGVILTSFTHPVMTWTASSSQSQRK
SIWPVISPDPVHPPMTRLHWTDILLMAVMCLSP
RF*SQTGQEIGKALMDSTAMGWELRVEKVRVSL
LTQATWRRRRWTVSLKCLQTALS*GAPCALFLPS
GGTAGGLGKMQPAMQK*TTGVQCEFLGMLSGDL
PFIGEVSV*KA*QEELVSETSHPHL*K*ALQMP
KSSDTHSVVRNGLTLWCHFQKRIWSQTRENIGCL
ISRYVTDLSSRDLITVHQPFPLH*QNPSH**QS
AILDWTIHGPSTVPSTIPVLI*LRV*QKRTIIS
CHIAPPRKILNGRVEQKSVVHSATSRIKCLAARR
AKKRKKKKIRLRRRRKILKTRRKIRRLSTGTLS
VPFLLWVPSAVASV*SPSPTKMPILVQIAVLLS
TKAAEKV*PPVQRSK*SSPKGAFRHMTHHHCPRS
L*ETSPHSPRSVLGPQSSWWMKPLPPQYLPIDD
PSRVSRSPKVSPYRTLLELAMMRTCQTPGNSCL
IQQTH*IKSARSMSQQNHLLMRE*VQT*MKDNYW
ETLRLSPNSWKQSLGVG**TASF*NSKRKMWSN
GKK*YMS*CRQSFIMSALSRS*VVCTARG*WRI
CFLSSRW*KSCSPVWMS*SVSIANSSRGFWSGRR
SLWWIKVKRTFSSRG*GMCL*ISFQVRMQNV*R
RHMASFVGNITSL*TTSKTFMPRISVFKPL*RR
R*AVQLLEGLEFQSAYCL*LSGLPSTQFYSKEYC
SVPKTMKWSRKI*HSP*AW*RM*LEL*TAKWQV
MKRKCVSMRFIQRQIASQS*G*RVVRCLPRKI*
NGRSLYVMGVCF*RMQQEG*KRFKQFFSLTF*FS
FKKKTRSTSLHHWTRSQQ*SL*RS*L*EKWHMR
RKVYS*SAWG*QIQRW*KSMPAPKRNETAGFRS
FRTQSTP*TEMKMKEFLVRMRKKRKCWTPEPEN*
KNNFTRRTKKSYSCWKRRR*FSGTWLSAAPLSQ
RIAPQHIALEFSSAPTQKRLSKEDL**KVQ*MR
WRSFRVW*VEIWEAHLGRLSAAPLSKMWSVPFPC
PGEQRPLEDLTAIR*MLQKEARRKREMMAKILG
ERNQIVA*KRVEMLTWYLCLKETVSRLSRALFI
STSSSALCRVWCCSRTATLRTRNWC*ARGRSLAA
CPARAPSLSRRSSAAWRSSARTWPTCRSSRPST
SRRSAGASVSGKLVRGSCGSGRPSWPSARRRCS
RGSRTWKRSGRSSSRRRAHTSMTWSDCVLPRNSL
RGNRSSCAGRQSGSASGRQNGTCVRFPIHIPS*
*GSHRSSPVLRSPPRHLHLP*PNQGHWTQNFQC
PQKGTASLGHTKIRGLFTY*VQPARQTKDQKGRA
RPLRPPLPLPACLG*QSQRKRRRKKRRTKPAAL
SPVMVPRQKYQQRVKRSSADPLPLC*GSCLLIL
ASPPLLLSPRAQVSYTGRPLLLSVQSSWAAPGPG
Q*ATDDIECRVGKEAQTLLRP*FVTAQDSQVGL
ALLRITLKVMAS*VQVMVLDTSGIPKG*KSVSK
*GLNLRMPFIWGNTKPNSRCFGLDLCTYMGTCLH
IHTGNARRRPSLHQASGQLSTRAVPGRTRSPRI
SAVHPVLLRDWFPSKPIPGTYHPCFACISHFIL
GMTNICETSERRLDVYKRRDVHHLDLGVSGTKAT
KQPIVSHSVIRSRRNILVFQHVYPHVLAMDKVK
RPTHHYPCSVTPFDCH*PLRRGHGLLAVFLSPR
RASPRQQLSGPCWVRAHHCQGSASHPGQAEAVL*
S*DSWLRSGFRRRVKPCVAVPASADLERSWPGR
RGCESALLMLGGLGKIGFLQKYM*RSVVELYSA
PGSRYRWLPAARLCFCFSHRVFIFVHLRLSPAGV
CRTVHGNVAL*GPVHQKGGPGKFCASNVAFNSC
FFAPRKHGAFEHT*KKKNL*LGAY**IASWPCR
WRYLSFSLFERGLV*NL*PTFVLFIVFVCLCLFF
FKGEPGLAQQSKLSSQYRVKWQPALFTLCLLKC
LEGPDEILKGGGPCPSLPHPASFFNQRMSSPLF
ENEETRHL*PTFAFFCHGEYSPFRNRPKAKTC*F
FY*KYVPLQRP*TKS*VSFFHLFVQLQVTAESV
VTFLRSTRGLAVCSGHWLRVPLLGFAGGQY*TC
ILLLVNVGRVPLFSGFGTIRGWC*WDLLAYVLFT
KTPWMLKLEHVATELDINVRGSLTPRPAVMFHL
LWLFWWSFLKIEISHLPRPHSKRFGQVLVGQV*
NQSSARNSLKPPNFIQEYSLQCSNRTAYQELCLH
TFVISLPPLEVVLRGICSCPGDLPGMVAACAFA
HGLDSALVAGSNGLSWFLSHEKGLFFWGDSD*I
PHTVSTPGHHVLHQAKEITCLKLCLSFGGKMEFL
SRAPRFPESSELPGRRLRLLSIPVISVVVVR*H
VHFKCSHRLASFSRQSNVLTVFSS*KMERVKNM
QTATFNLCQYSLYPRESYLGGRILTKVFLERYES
*LFSPSVSQGNTIQSRPFAHFLPYLLPS*GLSI
SREHKVLRPLALFLDVGGEVLVHARVELDRPCL
SRGWDYNLRGQNLIQKLLSTEVLSISSFLFLGLF
FCSQVFPRILVFALELRFTLMMVAQLCPEDSQA
GPGREFRKTVLVNGLQVVTKRVAVR*PQTLQND
VHPLRFGCPWNVGA*K*PCGWNWGSGCWRSVCLA
FLQQDRLGAQPPMDASQPAPSLSSILRDKEEGR
EFGLGFELSFQCSKAFLVNQSLGIYCLLARL*N
EKCFNAAIKGRRGGGRENKGIFPSTHLI*LSKD*
*AMNYFSISLRVKGVQPPTGCVPCHRSE*PALQ
PGGTTCAAVRRGFCRKHSPPTPSPA*ASPTFRH
HLRA*AQAMGRAW*VCLWFRLSLWSPVCCCPHGM
RRGGVGIRRRVVGIHRIPLLSLLVCKCSMDICV
LNPIK*KRRVKTQMLYIHL*LCIK*SSFKL*RF
FSVCFLEFCHNILASYFIYLSF*LPASDPCKVSL
SPFKK**ISCEVL
Frame 1
ELKWGK*RSKSFHDVWLSAAAQVTTSTQRKGGFWRQGGEETVGGHFPEQPLPATLL*SLCRRAAAA
VNLSLP*QPECPVQEPYYWSHAARWAVLPCNPSS
QFLLRVYSREDSQALPPSRVPRPPSRASFGACA
DWSCVQGQRGARAAAVKRLCSAETAVPIARLGR
RRFSRLRGSGRLLSFSAAKVKSCPSSARGGAPGA
ARVLGHET*STASSLIW*LCCYSAAC*RGQS*R
*CSVLLGIFGFHPPSLYKYSEGQF*YIGDHCSW
S*LL*NSEGAALCFQRGPSRVCGG*RRLSFRPG*
SV*CSSIPSNQCWKSAGFELYPFS*PVRTPIWG
CEFP**EVGAGIQAPEAAHGVECIGDRSEFA*C
WPARDIDAFCCAAGTAEVDVVPVAEARWPRSSQY
PQPGRGDACELGLGARLSQAAPASNRGECWRTR
LLEQFIL*NTVWRLFCEASSRVGHLYINL*V*F
TS*TPISWRRLHWTNF*TYEHPTATNENKPQADG
QSYALNDDSTGSFQCPRDRWPVSSLCTGAHGPS
ATFFF*RD*EHSVLPREPCCTD*KSL*FVKHS*
GGEYRPFL*EEK*RRGKKRGRGGASTYCGLWNCI
*SRQLPSELA*LWSKGHGRPFVLWKQK*RNWNK
IFWNAHRPGVPEQWRCCASERLGHGARHSPVFL
WR*TGRHFNNKCQYPRHCRGNGTWAHEPRCHCLE
ECASGRGKYKGKI*EL*YWHSWSL*RARHK*AC
G*NQCSKLCPCCQFPGW*QTC*VFTCI***RNL
H*KNSRNGNFTKS*GEC*CSSRSEFCGDSSCCKR
QDFRWIRTLYSLSSRHR*GNVTLRFSPSWAGRR
CNATPELRNKFISCSKPKGQILTHLFYNWRR*T
LCRLCMSTEHSDF*WRFGCKTV**HS*RVRKHHS
KATQLTRSTRCLPL*RPTGSYSHL*PCKGYPGT
CGFLSFQSGG*QRPTKRCETR*TFNKYA*GGFT
STSSCP*NGERTGARPGSNIRQYFLSGKQSRQ*I
SNQG*RTFFCPLPERKGNSNS*TTYSYRL*RWP
RWKFE*A*YAATRRQGSRPVHILHCCRASARDG
EYQSHRTWWRA*GSRPSSNPRSSEYQGEH*LFPA
KCG*GHFGFRFSFD*RRKTSGGFRKLCSSGTR*
G*SGDLFLY*GKCSLFRNFAGRAENTTSWTRYS
TIS*KINLS*LCQGQSTSAK*FTGCILCLS*GRN
*T*QGSGPTSLTADSRWGCPEPGATRSKSGHRV
KAGSLGGRAQQLRSVAMSVARWV*WVRCS*LQS
AFSSGCWSEEHSIPGKN*CL*GEWRCDGGCYRG*
CSTRYG*AQKREYITQHPRHPDSKRLVEPREEC
RSRFASGSTGQSCD*PTGSWNPRDDTS*LGERE
AGGSRPQLYHG*R*GSPNRR*STSCPTAACCQGA
PHRHGALSP**WGPSWCEGSHASPAFRQGKEHS
LSTLHGLCPGRTSA*GGRLDRGGCQPYSGCCHR
TSQGRWSTAY*GGGLSHVTVQP*VGSSH*RTREC
FYRKSEYFPTWGEPTNGQYS*GSHGEPCRMFCW
KGGAREDHFTCPGA*ASSRNARRES*R*SGF*S
KFNF*RSGCREHSCYTEDEARPNDPGDKPRKLVY
NRAMP*CSISSGFQAEPRM*ELPGCWTGQRVYL
KTRCT*KRIWE*F*PLSLTQ**HGQHHLPKARG
RAFGL*YHRIQFIHR*HGFTGPTFFSWQ*CVSLP
DFKAKQVKRSAKP*WILQPWDGS*GSRK*E*AC
*PRRRGGGGDGQYH*SACKLLCPKELHALSFSL
PEAQLGAWEKCSQRCRNEPPEFNASSWGCCQETS
HS*EKFQSRRLDRRSWCRKQAILISRSKLCKCR
RAQTPIQW*GTG*LFGVTFRRGSGVRPERT*DV
*SADMSQI*AAGI*LLYISHFLSIDKIHLINDNQ
PSWIGQFTALPQYLPQYQC*SD*EYNRREL*FP
AT*PLQERF*MEEWNKSQSYIQLHQE*NV*QQE
EQRKGKRKR*D*GEGERF*RQGER*EDCQRAHFQ
FHSCCGSHQL*PVYEALHQQRCLYLCKLQCFCP
QRLPRKSSLLCKGQNEAAQREPSGT*HIITAHG
HYEKQALTAQGASSVRSPPGG*NRYHPNICQ*TI
PAECLALQKCLHTEHYWSWQ**EHVKHLEIPVS
FNRLTK*NQQGQ*VNRITY**GSRYRHE*RTTT
GRL*D*VQTAGSRVLESDNRQQVSKTAKERCGQT
ARSNI*VDADRVSSCPHSQDHEWCVQPGDDGGS
AF*AADGRKAVPLFG*ADQYP*PILPEDSGAEE
GVSGG*K*KELSHQEDRGCACKSVFR*ECRTFKE
DIWQVLWAT*PVCKLLQRPLCQG*AFSSLCKEE
DEQFSC*KAWNSRVHIACNSADYQVPSFIPKNI
AVYQRQ*SGAGRSSTVLEPGEGCDWSCRQQSGKL
*KESASQ*DLYKDR*QVNHEDEEWSDVCQGRFE
TEEACT*WECVSEECSRKVERGSSSSSH*HFSF
PSRKRPEVHLCIIGPEVNSDLFKEADCERSGT*G
ERFIPDQHGDDRSRDGRSPCQLQRGTKQLDSDH
SGHNQHPEQR*R*RNS**E*GRKENVGHQSPRI
KRTTSPEGPKNPTLVGREGDDFPGHG*VQHPSPR
GLLPNT*P*SSLPLQHRRGSQRRTFNEKCNK*G
GDPSGFGEWKSGRHTWADCQQPH*ARCGRSRFP
APESRDLWRI*QPSDECFKRRREGRGR*WPRS*E
NGIR*WPKKGWKC*PGIYA*KKQ*AGCPERCSS
LRAPQRSAGCGAAAGQLH*GPETGAEREGAHSQ
LVPPELPH*AGEAAQPGEAAPGPGQPAEAAGPVP
RGEAQARA*VGSS*EGAAGAGGPPGPARGGGAA
GAAGPGKGAGGAPAEEGHIPV*PGATACCPETA
*EGTGAAAPGGRAAQPAADRTGPVSGFPSTYQAD
EDPIVLPQS*GAPLAICTFHSQIRVIGLRTFSV
PKKEQHLSDTQR*GAFSHTEFNQPDKQRTRRAE
PGPCVHLCLYPPVWVNKAKGKEGEKKEEQNQPLS
AR*WSRVRSISRG*RDLLLTLFLSAEAAAS*SW
PAHLSCCPRVHKSLTLDAHCSSASSPPGRPQVL
DNKQQMILSVGWGRRPRLCFGHDL*LPRTLRLGW
PYSGLH*K*WPRKYR*WFWTRQEFLKAERVYPS
KV*TSECLLFGGTQNQTADVLDLICVRTWGPVC
IYTRGMPEEGPVCTRRLVNLAQGQCLDGPGAPAY
QQFTQYSSETGFPLNPSRAHTTRVLHVFLISF*
G*QTFVKPVREGLMCIKDVMCTTSISVFQALKQ
QNNP*YLILSSDPEEISWFSSMFTHMFWPWIK*R
GLLTIIPAA*HLLIVTDHSEGATASWLCS*APV
VPLPDSSCLALAG*GHTTARGQPRTQARQKLCS
EARTAG*EVGSGEG*SHV*QFLPVQIWRGAGPEG
VVVKAPFLC*EALAKLDFFKNTCKGLLLNCTLP
LEADTDGCLLLGFAFAFPTVFSSLFT*GFPQLV
CAGQFMVMLPSEAPYTRREALENFVLPTWPSILA
FLPLGSMGLLSTLKKRKICNLVLIDELQAGLAD
GDIYLSVYLKEVWFKICSLHLFYLLYLCVCVCF
FLRVSQV*PNSLNYPVNTE*SGSQHCSLCVF*SA
LKAQMKF*REGVHVLPSPTPPHSLIKGCLLPCL
RMKKLATSDLPLPFSVMENTHPSETDQRPKPAD
FSIENMSPCKDPKQKVKFLSFTYLYNSKLQLNLS
*LS*DLPGAWLSVLGTGSEFPSWDLQEGSTEPA
FFSL*M*AGCPCSPGLEQYEVGADGIYLRTCSS
QKHRGC*S*STSPQSLTSMLEGLLLPAQL*CFIC
FGCFGGLF*K*RFHICPDPTQNDLVRFWLDKFK
IKVVPGIPSNHPTSSRNTVCSAATEPLTKNCAY
IPLSSLFPPWKLSSGGFVPVLGIYLGWWLPVLLL
MALTVL*LLDLMACLGFYHMRRGCFFGVTRTEF
PILFPRRDTMFSIKLKKSRA*NCA*VLGERWSS
YPEPPDFQNRVSFLEGDCVFSQFQSSQSLSLGDM
CTLNALIGWLHFQDNQMY*LCFLLRKWRGLKTC
KLPLSTFASIPSTPVRAIWGEESLPRFFWKGTN
LNFFPLLCLRVILFRVAPLLIFSRICYLPEASVL
VVSTKF*DLWRCFLMWEGRC*CMQGLN*IDPAL
VEGGTITLEART*SRSCCPQKCFLFHHFCF*GS
FSVARSSQGF*YLHWS*GLL**WWPSCAQRTARQ
ALGGSLERQSW*MGFKWSQRGWL*GDPRHCRTM
CTLCVLDVLGMWEPRNNPVDGIGAAAAGDLCAL
PSFSRTV*VRSHLWMRPSQPRRSRPSSETKKRAG
SLGLVLNFPFNVAKHS*LTRALESTACWPGFKM
KSVLMLP*KGGGGEEGKIKASFQVLI*FNCQKI
DRP*ITSPSH*GLKACNPPLAVSPATEVSDLPYN
QVGPPVLQSGGASAGSTHPPHLPRPELPLPFVT
T*GHEHRPWGVPGESACGSGLACGLLCAAARMG
CAGEAWGSAGGWLGYTGYLCSHCLFANALWTFVC
*ILLNKKDGLKPRCCIFICNYV*SEAVLNCKDF
FQCVFSNFATTYWLRILFIFLSSYQLQTLVKSP
SALSKNNKFPVKFW
Frame 2
S*SGGNRGVNHFTMCG*VLQLR*PPVHRGRAVSGDRAERRPWVGISQSSLCQPPYFDHFAAEQQRR
STSASLSNLSAPSRSLTIGLMQRDGQFCRAIPA
RSSCSACTHGRTRRRYRLPACPAHPPERLSAHAR
TGAVCRASAEPEQPR*SACALPRLPCPLLASVA
AALAASGGAAAYCLSPRRR*RVVPARPAGEPRE
PHVSWVMKLNPQQAPLYGDCVVTVLLAEEDKAED
DVVFYLVFLGSTLRHCTSTRKVSSDTLETIAPG
HDCCETVKVQLCASKEGLPVFVVAEEDFHFVQD
EAYDAAQFLATSAGNQQALNFTRFLDQSGPPSGD
VNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDA
GPRETLMHFAVRLGLLRLTWFLLQKPGGRGALS
IHNQEGATPVSLALERGYHKLHQLLTEENAGEPD
SWSSLSYEIPYGDCSVRHHRELDIYTLTSESDS
HHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQM
DSLMPLMMTAQDPSSAPETDGQFLPCAPEPTDPQ
RLSSSEETESTQCCPGSPVAQTESPCDLSSIVE
EENTDRSCRKKNKGVERKGEEVEPAPIVDSGTV
SDQDSCLQSLPDCGVKGTEGLSSCGNRNEETGTK
SSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSS
GGELGGISTTNVSTPDTAGEMEHGLMNPDATVW
KNVLQGGESTKERFENSNIGTAGASDVHVTSKPV
DKISVPNCAPAASSLDGNKPAESSLAFSNEETS
TEKTAETETSRSREESADAPVDQNSVVIPAAAK
DKISDGLEPYTLLAAGIGEAMSPSDLALLGLEED
VMPHQNSETNSSHAQSQKGKSSPICSTTGDDKL
CADSACQQNTVTSSGDLVAKLCDNIVSESESTT
ARQPSSQDPPDASHCEDPQAHTVTSDPVRDTQER
ADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSH
PHPVVPKMEKELVPDQAVISDSTFSLANSPGSE
SVTKDDALSFVPSQKEKGTATPELHTATDYRDGP
DGNSNEPDTRPLEDRAVGLSTSSTAAELQHGMG
NTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSL
QSVGKATLALDSVLTEEGKLLVVSESSAAQEQDK
DKAVTCSSIKENALSSGTLQEEQRTPPPGQDTQ
QFHEKSISADCAKDKALQLSNSPGASSAFLKAE
TEHNKEVAPQVSLLTQGGAAQSLVPPGASLATES
RQEALGAEHNSSALLPCLLPDGSDGSDALNCSQ
PSPLDVGVKNTQSQGKTSACEVSGDVTVDVTGV
NALQGMAEPRRENISHNTQDILIPNVLLSQEKNA
VLGLPVALQDKAVTDPQGVGTPEMIPLDWEKGK
LEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKE
LPTDMELSAHDDGAPAGVREVMRAPPSGRERSTP
SLPCMVSAQDAPLPKGADLIEEAASRIVDAVIE
QVKAAGALLTEGEACHMSLSSPELGPLTKGLES
AFTEKVSTFPPGESLPMGSTPEEATGSLAGCFAG
REEPEKIILPVQGPEPAAEMPDVKAEDEVDFRA
SSISEEVAVGSIAATLKMKQGPMTQAINRENWC
TIEPCPDAASLLASKQSPECENFLDVGLGRECTS
KQGVLKRESGSDSDLFHSPSDDMDSIIFPKPEE
EHLACDITGSSSSTDDTASLDRHSSHGSDVSLS
QILKPNRSRDRQSLDGFYSHGMGAEGRESESEPA
DPGDVEEEEMDSITEVPANCSVLRSSMRSLSPF
RRHSWGPGKNAASDAEMNHRSSMRVLGDVVRRP
PIHRRSFSLEGLTGGAGVGNKPSSSLEVSSANAE
ELRHPFSGEERVDSLVSLSEEDLESDQREHRMF
DQQICHRSKQQGFNYCTSAISSPLTKSISLMTI
SHPGLDNSRPFHSTFHNTSANLTESITEENYNFL
PHSPSKKDSEWKSGTKVSRTFSYIKNKMSSSKK
SKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTF
SSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVH
KGCRESLASCAKVKMKQPKGSLQAHDTSSLPTV
IMRNKPSQPKERPRSAVLLVDETATTPIFANRR
SQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH
STDSLNKISKVNESTESLTDEGVGTDMNEGQLL
GDFEIESKQLEAESWSRIIDSKFLKQQKKDVVK
RQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADL
LFEQQMVEKLFPCLDELISIHSQFFQRILERKK
ESLVDKSEKNFLIKRIGDVLVNQFSGENAERLK
KTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKK
MSSSVVRRLGIPECILLVTQRITKYPVLFQRIL
QCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVAS
YEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLK
RKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVF
LQEKDQKYIFASLDQKSTVISLKKLIVREVAHE
EKGLFLISMGMTDPEMVEVHASSKEERNSWIQII
QDTINTLNRDEDEGIPSENEEEKKMLDTRAREL
KEQLHQKDQKILLLLEEKEMIFRDMAECSTPLP
EDCSPTHSPRVLFRSNTEEALKGGPLMKSAINEV
EILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSL
PRRAETFGGFDSHQMNASKGGEKEEGDDGQDLR
RTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHL
YELLSALQGVVLQQDSYIEDQKLVLSERALTRS
LSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQY
LEEKRRREREWEARERELREREALLAQREEEVQQ
GQQDLEKEREELQQKKGTYQYDLERLRAAQKQL
EREQEQLRREAERLSQRQTERDLCQVSHPHTKL
MRIPSFFPSPEEPPSPSAPSIAKSGSLDSELSVS
PKRNSISRTHKDKGPFHILSSTSQTNKGPEGQS
QAPASTSASTRLFGLTKPKEKKEKKKKNKTSRS
QPGDGPASEVSAEGEEIFC*PSSSLLRQLPPDPG
QPTSPAVPACTSLLHWTPTAPQRPVLLGGPRSW
TISNR*Y*VSGGEGGPDSASAMICDCPGLSGWA
GPTQDYTESNGLVSTGDGFGHVRNS*RLKECIQV
RSEPPNAFYLGEHKTKQQMFWT*SVYVHGDLSA
YTHGECQKKAQSAPGVWST*HKGSAWTDPEPPH
ISSSPSTPQRLVSL*THPGHIPPVFCMYFSFHFR
DDKHL*NQ*EKA*CV*KT*CAPPRSRCFRH*SN
KTTHSISFCHQIQKKYPGFPACLPTCFGHG*SE
EAYSPLSLQRDTF*LSLTTQKGPRPPGCVPEPPS
CLSQTAAVWPLLGEGTPLPGVSLAPRPGRSCAL
KLGQLAEKWVQAKGEAMCSSSCQCRSGEELARK
AWL*KRPSYVRRPWQNWISSKIHVKVCC*IVLCP
WKQIQMAACCSALLLLFPPCFHLCSLEAFPSWC
VQDSSW*CCPLRPRTPEGRPWKILCFQRGLQFL
LFCPSEAWGF*AHLKKEKSVTWCLLMNCKLALQM
EIFIFQFI*KRSGLKFVAYICFIYCICVFVFVF
F*G*ARSSPTV*TIQSIPSEVAASTVHSVSFEV
P*RPR*NFKGRGSMSFPPPPRLIL*SKDVFSLV*
E*RNSPPLTYLCLFLSWRILTLQKQTKGQNLLI
FLLKICPLAKTLNKKLSFFLSPICTTPSYS*IC
RDFPEIYPGLGCLFWALAPSSPPGICRRAVLNLH
SSPCKCRPGAPVLRVWNNTRLVLMGFTCVRALH
KNTVDAEVRARRHRA*HQC*RVSYSPPSCDVSS
ALVVLVVFFKNRDFTSAQTPLKTIWSGSGWTSLK
SK*CPEFPQTTQLHPGIQSAVQQQNRLPRTVLT
YLCHLSSPLGSCPQGDLFLSWGFTWDGGCLCFC
SWP*QCSSCWI*WPVLVSIT*EGVVFLG*LGLNS
PYCFHAGTPCSPSS*RNHVPETVLKFWGKDGVP
IQSPQISRIE*ASWKETASSLNSSHLSRCR*VT
CAL*MLSSVGFIFKTIKCIDCVFFLENGEG*KHA
NCHFQPLPVFPLPP*ELSGGKNPYQGFFGKVRI
LTFFPFCVSG*YYSESPLCSFSPVFVTFLRPQY
*S*AQSFETFGVVS*CGRGGVSACKG*TR*TLP*
*RVGL*P*RPELDPEVAVHRSAFYFIIFVSRAL
FL*PGLPKDFSICIGVEVYSNDGGPAVPRGQPG
RPWEGV*KDSPGEWASSGHKEGGCEVTPDTAERC
APSAFWMSLECGSLEITLWMELGQRLLEICVPC
LPSAGPSRCAATYGCVPASPVALVHPQRQRRGQ
GVWAWF*TFLSM*QSIPS*PEPWNLLPAGQALK*
KVF*CCHKREAGGRKGK*RHLSKYSSNLIVKRL
IGHELLLHLTKG*RRATPHWLCPLPPK*VTCPT
TRWDHLCCSPEGLLQEALTPHTFPGLSFPYLSSP
PEGMSTGHGACLVSLPVVQA*PVVSCVLLPAWD
AQGRRGDPQEGGWDTPDTSALIACLQMLYGHLC
AKSY*IKKTG*NPDAVYSFVIMYKVKQF*TVKIF
FSVFSRILPQHTGFVFYLSFFLVTSFRPL*SLP
QPFQKIINFL*SS
Sequence AKAP13.fAug05
GTTCCATCTGTGGGTAACCATGTTCCGAGGCAGCAAAGAGAAACCGCTATTGCTCCGTGGAAATAAACTATCTGAATAAAACTTCTTAACGGGGGTTGAGGCTGAAGCTGAAACGGGAGTCGGACACGATCTTGGCTCCTGAAGTCTTTAAAGGTCAGTTTGATGCACACTTCTATACCACCACCTGTTACCAGCTGTAG
ACAGAAGACCTATCTCCATGCTTGCCCCTAGGCTTTTGTAGAAATGCCAGACGTGAAAGCTGAAGATGAAGTGGATTTTAGAGCAAGTTCAATTTCTGAA
GAAGTGGCTGTAGGGAGCATAGCTGCTACACTGAAGATGAAGCAAGGCCCAATGACCCAGGCGATAAACCGAGAAAACTGGTGTACAATAGAGCCATGCC
CTGATGCAGCATCTCTTCTGGCTTCCAAGCAGAGCCCAGAATGTGAGAACTTCCTGGATGTTGGACTGGGCAGAGAGTGTACCTCAAAACAAGGTGTACT
TAAAAGAGAATCTGGGAGTGATTCTGACCTCTTTCACTCACCCAGTGATGACATGGACAGCATCATCTTCCCAAAGCCAGAGGAAGAGCATTTGGCCTGT
GATATCACCGGATCCAGTTCATCCACCGATGACACGGCTTCACTGGACCGACATTCTTCTCATGGCAGTGATGTGTCTCTCTCCCAGATTTTAAAGCCAA
ACAGGTCAAGAGATCGGCAAAGCCTTGATGGATTCTACAGCCATGGGATGGGAGCTGAGGGTCGAGAAAGTGAGAGTGAGCCTGCTGACCCAGGCGACGT
GGAGGAGGAGGAGATGGACAGTATCACTGAAGTGCCTGCAAACTGCTCTGTCCTAAGGAGCTCCATGCGCTCTCTTTCTCCCTTCCGGAGGCACAGCTGG
GGGCCTGGGAAAAATGCAGCCAGCGATGCAGAAATGAACCACCGGAGTTCAATGCGAGTTCTTGGGGATGTTGTCAGGAGACCTCCCATTCATAGGAGAA
GTATGAGCTGGTGCCCCTCTGGTGTGCAGTACTCTGCTGGCCTGAGTGCTGACTTTAATTACAGAAGTTTCAGTCTAGAAGGCTTGACAGGAGGAGCTGG
TGTCGGAAACAAGCCATCCTCATCTCTAGAAGTAAGCTCTGCAAATGCCGAAGAGCTCAGACACCCATTCAGTGGTGAGGAACGGGTTGACTCTTTGGTG
TCACTTTCAGAAGAGGATCTGGAGTCAGACCAGAGAGAACATAGGATGTTTGATCAGCAGATATGTCACAGATCTAAGCAGCAGGGATTTAATTACTGTA
CATCAGCCATTTCCTCTCCATTGACAAAATCCATCTCATTAATGACAATCAGCCATCCTGGATTGGACAATTCACGGCCCTTCCACAGTACCTTCCACAA
TACCAGTGCTAATCTGACTGAGAGTATAACAGAAGAGAACTATAATTTCCTGCCACATAGCCCCTCCAAGAAAGATTCTGAATGGAAGAGTGGAACAAAA
GTCAGTCGTACATTCAGCTACATCAAGAATAAAATGTCTAGCAGCAAGAAGAGCAAAGTGAGTATCACTGTGGGCATTGCTTGTGATCACCTCAGTAGGA
TCCTGTCACAGCCTGCATTCACACCAAAACTGGTTAAATCATGGGGACATAAATGGAAATAAATTCAGGATTACTCTCCGAAATCGCCTAATATTTAAAG
GAAAATAATAAGAAGAAAAATAGCAAGAAGTGGAACTACCAGTTACTGAGTTTTCACTATATGCTAAGTGCTTTCCATATATTATTTAACCCTTTCAACA
ACCCTGTCAGGTAGGTGTTATCTCTCTTTTCTAAAAGTGATGTACCTTACCGAGGATACTCCTCTAATGTGAAGAAGTAGTTCAAACCAGATCTCTTTGG
TTTCAAATCCCATACTCTTAAACCACAGTGCTTAAATCTGTAATATCAGTTTAAATGCAACAGAAGGATTTTATGCAAAGATCAAAGGATTGAAAATATT
TATATTTGGCTTTAGAGGGAAGGATTATCCCACAGAAGATTACAAGAACTTTTAAGACTAATATGATTTCTTAGATCTATTTCTAATTAGGAGCATTTGG
AATATATTCTCTTAGTGATTAAGAGATTAAATAAATGTTTAAACCGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTGTGTGTGTGTGTGTAAGGCTCCA
CTGTATCACCCAGGCTGGAGCACAGTGGCGTGACCATAGCTCACTGCAGTCTTGAACTGCCAGGCTTAAGCAGTTTCCTGCCTCGCACCGTAGCCTCCCG
AGTAGCCAGGGCTACAGTCATGTTGTGCCATCGTGCTGAGCTATGTTTAAATTTGTTTGTAAAGATGAAGTCTTGCTGTTGTGTCTAGGCCGGTCTAATG
CCTTACCTCAAACACTCTTCTCGCTGCAGGCTTCCGAAGCCCTGGGTGTGATCCACCGTGCCCAGCCTAAAGTAACATTTTTTATCTAATTATTTTTCAC
ATGCTCATTATGGAAATCTTCAAAATCTAAAAGTAAAAGAATGAAAATCTCCTGGAATAACCCCGCTTAGAGATAACTACACTTAATGTTTTGGTTTATA
TATTTCTAATCTTTTTTAAAAATGTATTTTCAAAAGAAAGGGAGAAAAGAAGTTCACTTTCTTATACTGATTCCCAGTGCTAAACCAAAACTGATTCCAT
TTCAAGTCCGTGGGGAAAAACTTTTCGCCTCTCACACCCTGTTCATCTACCCACAACACCCTCTAACAAAATAAAGACATAAGTAAATAAAAATTTGAAA
TCAGTTAAGGAACTCTTGCAAGGAATCACTGTGTGTGTGTGTGTGTGTGTATGTGTGTGTGTGCACGTGCATGCATGTGTGTGTGTGTGTGGTATATACA
TGTACATACAGATATATACACACGTAGATACATGCATATTTAGAAGTAAGGGAATAAACAAACATTGAATTCAAGAATATTGTCATAAAAGGGCATTGCC
TCCTCCCTCACAAAACAAGGTGCACTAAGCTTCTCAAGCCCTCACTTCAGTGGGCTGATGGAAATATAGCCAAAGTATTTTACCATGTTTTGTAAGATCT
CTTGGTTTAGCAAATACATTCAAAGAAATTTTTCCACCAAACGTGCCACAAGAATTGTGTTTTCATTTCTCCTGTGCAAGTACAGAATGGAGAGAAAGTA
GGCAATCAGGGAGAGATGCAAAGAGTCTAGCAAATTATTTCTAGCATAATCACACATTTAACTTCAGACTCAGCCTTGTTTTATAATTCCAAAAAAAAAA
AAAATGAAGGTCAAAGAATACTGCTTTACCAGTATTCTACGTATTTACATATTGGCAGCCAGGCTTAAAATAGAGCCTTACCTTTTTTACTTACCACTGC
CGGCTTGGATACTAGTTGG
- AKAP13-F1 (forward primer)
- AKAP13-R1 (reverse primer)
- Single exon skipping
Frame 0
VPSVGNHVPRQQRETAIAPWK*TI*IKLLNGG*G*S*NGSRTRSWLLKSLKVSLMHTSIPPPVTSCR
QKTYLHACP*AFVEMPDVKAEDEVDFRASSISE
EVAVGSIAATLKMKQGPMTQAINRENWCTIEPC
PDAASLLASKQSPECENFLDVGLGRECTSKQGVL
KRESGSDSDLFHSPSDDMDSIIFPKPEEEHLAC
DITGSSSSTDDTASLDRHSSHGSDVSLSQILKP
NRSRDRQSLDGFYSHGMGAEGRESESEPADPGDV
EEEEMDSITEVPANCSVLRSSMRSLSPFRRHSW
GPGKNAASDAEMNHRSSMRVLGDVVRRPPIHRR
SMSWCPSGVQYSAGLSADFNYRSFSLEGLTGGAG
VGNKPSSSLEVSSANAEELRHPFSGEERVDSLV
SLSEEDLESDQREHRMFDQQICHRSKQQGFNYC
TSAISSPLTKSISLMTISHPGLDNSRPFHSTFHN
TSANLTESITEENYNFLPHSPSKKDSEWKSGTK
VSRTFSYIKNKMSSSKKSKVSITVGIACDHLSR
ILSQPAFTPKLVKSWGHKWK*IQDYSPKSPNI*R
KIIRRKIARSGTTSY*VFTIC*VLSIYYLTLST
TLSGRCYLSFLKVMYLTEDTPLM*RSSSNQISL
VSNPILLNHSA*ICNISLNATEGFYAKIKGLKIF
IFGFRGKDYPTEDYKNF*D*YDFLDLFLIRSIW
NIFS**LRD*INV*TVCVCVCVCVSVCVCV*GS
TVSPRLEHSGVTIAHCSLELPGLSSFLPRTVASR
VARATVMLCHRAELCLNLFVKMKSCCCV*AGLM
PYLKHSSRCRLPKPWV*STVPSLK*HFLSNYFS
HAHYGNLQNLKVKE*KSPGITPLRDNYT*CFGLY
ISNLF*KCIFKRKGEKKFTFLY*FPVLNQN*FH
FKSVGKNFSPLTPCSSTHNTL*QNKDISK*KFE
IS*GTLARNHCVCVCVCMCVCARACMCVCVWYIH
VHTDIYTRRYMHI*K*GNKQTLNSRILS*KGIA
SSLTKQGALSFSSPHFSGLMEI*PKYFTMFCKI
SWFSKYIQRNFSTKRATRIVFSFLLCKYRMERK*
AIRERCKESSKLFLA*SHI*LQTQPCFIIPKKK
KMKVKEYCFTSILRIYILAARLKIEPYLFYLPL
PAWILV
Frame 1
FHLWVTMFRGSKEKPLLLRGNKLSE*NFLTGVEAEAETGVGHDLGS*SL*RSV*CTLLYHHLLPAV
DRRPISMLAPRLL*KCQT*KLKMKWILEQVQFLK
KWL*GA*LLH*R*SKAQ*PRR*TEKTGVQ*SHA
LMQHLFWLPSRAQNVRTSWMLDWAESVPQNKVY
LKENLGVILTSFTHPVMTWTASSSQSQRKSIWPV
ISPDPVHPPMTRLHWTDILLMAVMCLSPRF*SQ
TGQEIGKALMDSTAMGWELRVEKVRVSLLTQAT
WRRRRWTVSLKCLQTALS*GAPCALFLPSGGTAG
GLGKMQPAMQK*TTGVQCEFLGMLSGDLPFIGE
V*AGAPLVCSTLLA*VLTLITEVSV*KA*QEEL
VSETSHPHL*K*ALQMPKSSDTHSVVRNGLTLWC
HFQKRIWSQTRENIGCLISRYVTDLSSRDLITV
HQPFPLH*QNPSH**QSAILDWTIHGPSTVPST
IPVLI*LRV*QKRTIISCHIAPPRKILNGRVEQK
SVVHSATSRIKCLAARRAK*VSLWALLVITSVG
SCHSLHSHQNWLNHGDINGNKFRITLRNRLIFK
GK**EEK*QEVELPVTEFSLYAKCFPYII*PFQQ
PCQVGVISLF*K*CTLPRILL*CEEVVQTRSLW
FQIPYS*TTVLKSVISV*MQQKDFMQRSKD*KY
LYLALEGRIIPQKITRTFKTNMIS*IYF*LGAFG
IYSLSD*EIK*MFKPCVCVCVCVCLCVCVCKAP
LYHPGWSTVA*P*LTAVLNCQA*AVSCLAP*PP
E*PGLQSCCAIVLSYV*ICL*R*SLAVVSRPV*C
LTSNTLLAAGFRSPGCDPPCPA*SNIFYLIIFH
MLIMEIFKI*K*KNENLLE*PRLEITTLNVLVY
IFLIFFKNVFSKEREKRSSLSYTDSQC*TKTDSI
SSPWGKTFRLSHPVHLPTTPSNKIKT*VNKNLK
SVKELLQGITVCVCVCVCVCVHVHACVCVCGIY
MYIQIYTHVDTCIFRSKGINKH*IQEYCHKRALP
PPSQNKVH*ASQALTSVG*WKYSQSILPCFVRS
LGLANTFKEIFPPNVPQELCFHFSCASTEWRES
RQSGRDAKSLANYF*HNHTFNFRLSLVL*FQKKK
K*RSKNTALPVFYVFTYWQPGLK*SLTFFTYHC
RLGY*L
Frame 2
SICG*PCSEAAKRNRYCSVEINYLNKTS*RGLRLKLKRESDTILAPEVFKGQFDAHFYTTTCYQL*
TEDLSPCLPLGFCRNARRES*R*SGF*SKFNF*
RSGCREHSCYTEDEARPNDPGDKPRKLVYNRAMP
*CSISSGFQAEPRM*ELPGCWTGQRVYLKTRCT
*KRIWE*F*PLSLTQ**HGQHHLPKARGRAFGL
*YHRIQFIHR*HGFTGPTFFSWQ*CVSLPDFKAK
QVKRSAKP*WILQPWDGS*GSRK*E*AC*PRRR
GGGGDGQYH*SACKLLCPKELHALSFSLPEAQL
GAWEKCSQRCRNEPPEFNASSWGCCQETSHS*EK
YELVPLWCAVLCWPEC*L*LQKFQSRRLDRRSW
CRKQAILISRSKLCKCRRAQTPIQW*GTG*LFG
VTFRRGSGVRPERT*DV*SADMSQI*AAGI*LLY
ISHFLSIDKIHLINDNQPSWIGQFTALPQYLPQ
YQC*SD*EYNRREL*FPAT*PLQERF*MEEWNK
SQSYIQLHQE*NV*QQEEQSEYHCGHCL*SPQ*D
PVTACIHTKTG*IMGT*MEINSGLLSEIA*YLK
ENNKKKNSKKWNYQLLSFHYMLSAFHILFNPFN
NPVR*VLSLFSKSDVPYRGYSSNVKK*FKPDLFG
FKSHTLKPQCLNL*YQFKCNRRILCKDQRIENI
YIWL*REGLSHRRLQELLRLI*FLRSISN*EHL
EYILLVIKRLNKCLNRVCVCVCVCVCVCVCVRLH
CITQAGAQWRDHSSLQS*TARLKQFPASHRSLP
SSQGYSHVVPSC*AMFKFVCKDEVLLLCLGRSN
ALPQTLFSLQASEALGVIHRAQPKVTFFI*LFFT
CSLWKSSKSKSKRMKISWNNPA*R*LHLMFWFI
YF*SFLKMYFQKKGRKEVHFLILIPSAKPKLIP
FQVRGEKLFASHTLFIYPQHPLTK*RHK*IKI*N
QLRNSCKESLCVCVCVYVCVCTCMHVCVCVVYT
CTYRYIHT*IHAYLEVRE*TNIEFKNIVIKGHC
LLPHKTRCTKLLKPSLQWADGNIAKVFYHVL*DL
LV*QIHSKKFFHQTCHKNCVFISPVQVQNGEKV
GNQGEMQRV*QIISSIITHLTSDSALFYNSKKK
KNEGQRILLYQYSTYLHIGSQA*NRALPFLLTTA
GLDTSW
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