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Sequences

Sequence AKAP13.cAug05

GCCAAAAGGGCAAATCCTCACCCATTTGTTCTACAACTGGAGACGATAAACTTTGTGCAGACTCTGCATGTCAACAGAACACAGTGACTTCTAGTGGCGA TTTGGTTGCAAAACTGTGTGATAACATAGTTAGCGAGTCCGAAAGCACCACAGCAAGGCAACCCAGCTCACAAGATCCACCCGATGCCTCCCACTGTGAA GACCCACAGGCTCATACAGTCACCTCTGACCCTGTAAGGGATACCCAGGAACGTGCGGATTTTTGTCCTTTCAAAGTGGTGGATAACAAAGGCCAACGAA AAGATGTGAAACTAGATAAACCTTTAACAAATATGCTTGAGGTGGTTTCACATCCACATCCAGTTGTCCCTAAAATGGAGAAAGAACTGGTGCCAGACCA GGCAGTAATATCAGACAGTACTTTCTCTCTGGCAAACAGTCCAGGCAGTGAATCAGTAACCAAGGATGACGCACTTTCTTTTGTCCCCTCCCAGAAAGAA AAGGGAACAGCAACTCCTGAACTACATACAGCTACAGATTATAGAGATGGCCCAGATGGAAATTCGAATGAGCCTGATACGCGGCCACTAGAAGACAGGG CAGTAGGCCTGTCCACATCCTCCACTGCTGCAGAGCTTCAGCACGGGATGGGGAATACCAGTCTCACAGGACTTGGTGGAGAGCATGAGGGTCCCGCCCC TCCAGCAATCCCAGAAGCTCTGAATATCAAGGGGAACACTGACTCTTCCCTGCAAAGTGTGGGTAAGGCCACTTTGGCTTTAGATTCAGTTTTGACTGAA GAAGGAAAACTTCTGGTGGTTTCAGAAAGCTCTGCAGCTCAGGAACAAGATAAGGATAAAGCGGTGACCTGTTCCTCTATTAAGGAAAATGCTCTCTCTT CAGGAACTTTGCAGGAAGAGCAGAGAACACCACCTCCTGGACAAGATACTCAACAATTTCATGAAAAATCAATCTCAGCTGACTGTGCCAAGGACAAAGC ACTTCAGCTAAGTAATTCACCGGGTGCATCCTCTGCCTTTCTTAAGGCAGAAACTGAACATAACAAGGAAGTGGCCCCACAAGTCTCACTGCTGACTCAA GGTGGGGCTGCCCAGAGCCTGGTGCCACCAGGAGCAAGTCTGGCCACAGAGTCAAGGCAGGAAGCCTTGGGGGCAGAGCACAACAGCTCCGCTCTGTTGC CATGTCTGTTGCCAGATGGGTCTGATGGGTCCGATGCTCTTAACTGCAGTCAGCCTTCTCCTCTGGATGTTGGAGTGAAGAACACTCAATCCCAGGGAAA AACTAGTGCCTGTGAGGTGAGTGGAGATGTGACGGTGGATGTTACAGGGGTTAATGCTCTACAAGGTATGGCTGAGCCCAGAAGAGAGAATATATCACAC AACACCCAAGACATCCTGATTCCAAACGTCTTGTTGAGCCAAGAGAAGAATGCCGTTCTAGGTTTGCCAGTGGCTCTACAGGACAAAGCTGTGACTGACC CACAGGGAGTTGGAACCCCAGAGATGATACCTCTTGATTGGGAGAAAGGGAAGCTGGAGGGAGCAGACCACAGCTGTACCATGGGTGACGCTGAGGAAGC CCAAATAGACGATGAAGCACATCCTGTCCTACTGCAGCCTGTTGCCAAGGAGCTCCCCACAGACATGGAGCTCTCAGCCCATGATGATGGGGCCCCAGCT GGTGTGAGGGAAGTCATGCGAGCCCCGCCTTCAGGCAGGGAAAGGAGCACTCCCTCTCTACCTTGCATGGTCTCTGCCCAGGACGCACCTCTGCCTAAGG GGGCAGACTTGATAGAGGAGGCTGCCAGCCGTATAGTGGATGCTGTCATCGAACAAGTCAAGGCCGCTGGAGCACTGCTTACTGAGGGGGAGGCCTGTCA CATGTCACTGTCCAGCCCTGAGTTGGGTCCTCTCACTAAAGGACTAGAGAGTGCTTTTACAGAAAAAGTGAGTACTTTCCCACCTGGGGAGAGCCTACCA ATGGGCAGTACTCCTGAGGAAGCCACGGGGAGCCTTGCAGGATGTTTTGCTGGAAGGGAGGAGCCAGAGAAGATCATTTTACCTGTCCAGGGGCCTGAGC CAGCAGCAGAAATGCCAGACGTGAAAGCTGAAGATGAAGTGGATTTTAGAGCAAGTTCAATTTCTGAAGAAGTGGCTGTAGGGAGCATAGCTGCTACACT GAAGATGAAGCAAGGCCCAATGACCCAGGCGATAAACCGAGAAAACTGGTGTACAATAGAGCCATGCCCTGATGCAGCATCTCTTCTGGCTTCCAAGCAG AGCCCAGAATGTGAGAACTTCCTGGATGTTGGACTGGGCAGAGAGTGTACCTCAAAACAAGGTGTACTTAAAAGAGAATCTGGGAGTGATTCTGACCTCT TTCACTCACCCAGTGATGACATGGACAGCATCATCTTCCCAAAGCCAGAGGAAGAGCATTTGGCCTGTGATATCACCGGATCCAGTTCATCCACCGATGA CACGGCTTCACTGGACCGACATTCTTCTCATGGCAGTGATGTGTCTCTCTCCCAGATTTTAAAGCCAAACAGGTCAAGAGATCGGCAAAGCCTTGATGGA TTCTACAGCCATGGGATGGGAGCTGAGGGTCGAGAAAGTGAGAGTGAGCCTGCTGACCCAGGCGACGTGGAGGAGGAGGAGATGGACAGTATCACTGAAG TGCCTGCAAACTGCTCTGTCCTAAGGAGCTCCATGCGCTCTCTTTCTCCCTTCCGGAGGCACAGCTGGGGGCCTGGGAAAAATGCAGCCAGCGATGCAGA AATGAACCACCGGAGTTTCAGTCTAGAAGGCTTGACAGGAGGAGCTGGTGTCGGAAACAAGCCATCCTCATCTCTAGAAGTAAGCTCTGCAAATGCCGAA GAGCTCAGACACCCATTCAGTGGTGAGGAACGGGTTGACTCTTTGGTGTCACTTTCAGAAGAGGATCTGGAGTCAGACCAGAGAGAACATAGGATGTTTG ATCAGCAGATATGTCACAGATCTAAGCAGCAGGGATTTAATTACTGTACATCAGCCATTTCCTCTCCATTGACAAAATCCATCTCATTAATGACAATCAG CCATCCTGGATTGGACAATTCACGGCCCTTCCACAGTACCTTCCACAATACCAGTGCTAATCTGACTGAGAGTATAACAGAAGAGAACTATAATTTCCTG CCACATAGCCCCTCCAAGAAAGATTCTGAATGGAAGAGTGGAACAAAAGTCAGTCGTACATTCAGCTACATCAAGAATAAAATGTCTAGCAGCAAGAAGA GCAAAGAAAAGGAAAAAGAAAAAGATAAGATTAAGGAGAAGGAGAAAGATTCTAAAGACAAGGAGAAAGATAAGAAGACTGTCAACGGGCACACTTTCAG TTCCATTCCTGTTGTGGGTCCCATCAGCTGTAGCCAGTGTATGAAGCCCTTCACCAACAAAGATGCCTATACTTGTGCAAATTGCAGTGCTTTTGTCCAC AAAGGCTGCCGAGAAAGTCTAGCCTCCTGTGCAAAGGTCAAAATGAAGCAGCCCAAAGGGAGCCTTCAGGCACATGACACATCATCACTGCCCACGGTCA TTATGAGAAACAAGCCCTCACAGCCCAAGGAGCGTCCTCGGTCCGCAGTCCTCCTGGTGGATGAAACCGCTACCACCCCAATATTTGCCAATAGACGATC CCAGCAGAGTGTCTCGCTCTCCAAAAGTGTCTCCATACAGAACATTACTGGAGTTGGCAATGATGAGAACATGTCAAACACCTGGAAATTCCTGTCTCAT TCAACAGACTCACTAAATAAAATCAGCAAGGTCAATGAGTCAACAGAATCACTTACTGATGAGGGTACAGACATGAATGAAGGACAACTACTGGGAGACT TTGAGATTGAGTCCAAACAGCTGGAAGCAGAGTCTTGGAGTCGGATAATAGACAGCAAGTTTCTAAAACAGCAAAAGAAAGATGTGGTCAAACGGCAAGA AGTAATATATGAGTTGATGCAGACAGAGTTTCATCATGTCCGCACTCTCAAGATCATGAGTGGTGTGTACAGCCAGGGGATGATGGCGGATCTGCTTTTT GAGCAGCAGATGGTAGAAAAGCTGTTCCCCTGTTTGGATGAGCTGATCAGTATCCATAGCCAATTCTTCCAGAGGATTCTGGAGCGGAAGAAGGAGTCTC TGGTGGATAAAAGTGAAAAGAACTTTCTCATCAAGAGGATAGGGGATGTGCTTGTAAATCAGTTTTCAGGTGAGAATGCAGAACGTTTAAAGAAGACATA TGGCAAGTTTTGTGGGCAACATAACCAGTCTGTAAACTACTTCAAAGACCTTTATGCCAAGGATAAGCGTTTTCAAGCCTTTGTAAAGAAGAAGATGAGC AGTTCAGTTGTTAGAAGGCTTGGAATTCCAGAGTGCATATTGCTTGTAACTCAGCGGATTACCAAGTACCCAGTTTTATTCCAAAGAATATTGCAGTGTA CCAAAGACAATGAAGTGGAGCAGGAAGATCTAGCACAGTCCTTGAGCCTGGTGAAGGATGTGATTGGAGCTGTAGACAGCAAAGTGGCAAGTTATGAAAA GAAAGTGCGTCTCAATGAGATTTATACAAAGACAGATAGCAAGTCAATCATGAGGATGAAGAGTGGTCAGATGTTTGCCAAGGAAGATTTGAAACGGAAG AAGCTTGTACGTGATGGGAGTGTGTTTCTGAAGAATGCAGCAGGAAGGTTGAAAGAGGTTCAAGCAGTTCTTCTCACTGACATTTTAGTTTTCCTTCAAG AAAAAGACCAGAAGTACATCTTTGCATCATTGGACCAGAAGTCAACAGTGATCTCTTTAAAGAAGCTGATTGTGAGAGAAGTGGCACATGAGGAGAAAGG TTTATTCCTGATCAGCATGGGGATGACAGATCCAGAGATGGTAGAAGTCCATGCCAGCTCCAAAGAGGAACGAAACAGCTGGATTCAGATCATTCAGGAC ACAATCAACACCCTGAACAGAGATGAAGATGAAGGAATTCCTAGTGAGAATGAGGAAGAAAAGAAAATGTTGGACACCAGAGCCCGAGAATTAAAAGAAC AACTTCACCAGAAGGACCAAAAAATCCTACTCTTGTTGGAAGAGAAGGAGATGATTTTCCGGGACATGGCTGAGTGCAGCACCCCTCTCCCAGAGGATTG CTCCCCAACACATAGCCCTAGAGTTCTCTTCCGCTCCAACACAGAAGAGGCTCTCAAAGGAGGACCTTTAATGAAAAGTGCAATAAATGAGGTGGAGATC CTTCAGGGTTTGGTGAGTGGAAATCTGGGAGGCACACTTGGGCCGACTGTCAGCAGCCCCATTGAGCAAGATGTGGTCGGTCCCGTTTCCCTGCCCCGGA GAGCAGAGACCTTTGGAGGATTTGACAGCCATCAGATGAATGCTTCAAAAGGAGGCGAGAAGGAAGAGGGAGATGATGGCCAAGATCTTAGGAGAACGGA ATCAGATAGTGGCCTAAAAAAGGGTGGAAATGCTAACCTGGTATTTATGCTTAAAAGAAACAGTGAGCAGGTTGTCCAGAGCGTTGTTCATCTCTACGAG CTCCTCAGCGCTCTGCAGGGTGTGGTGCTGCAGCAGGACAGCTACATTGAGGACCAGAAACTGGTGCTGAGCGAGAGGGCGCTCACTCGCAGCTTGTCCC GCCCGAGCTCCCTCATTGAGCAGGAGAAGCAGCGCAGCCTGGAGAAGCAGCGCCAGGACCTGGCCAACCTGCAGAAGCAGCAGGCCCAGTACCTCGAGGA GAAGCGCAGGCGCGAGCGTGAGTGGGAAGCTCGTGAGAGGGAGCTGCGGGAGCGGGAGGCCCTCCTGGCCCAGCGCGAGGAGGAGGTGCAGCAGGGGCAG CAGGACCTGGAAAAGGAGCGGGAGGAGCTCCAGCAGAAGAAGGGCACATACCAGTATGACCTGGAGCGACTGCGTGCTGCCCAGAAACAGCTTGAGAGGG AACAGGAGCAGCTGCGCCGGGAGGCAGAGCGGCTCAGCCAGCGGCAGACAGAACGGGACCTGTGTCAGGTTTCCCATCCACATACCAAGCTGATGAGGAT CCCATCGTTCTTCCCCAGTCCTGAGGAGCCCCCCTCGCCATCTGCACCTTCCATAGCCAAATCAGGGTCATTGGACTCAGAACTTTCAGTGTCCCCAAAA AGGAACAGCATCTCTCGGACACACAAAGATAAGGGGCCTTTTCACATACTGAGTTCAACCAGCCAGACAAACAAAGGACCAGAAGGGCAGAGCCAGGCCC CTGCGTCCACCTCTGCCTCTACCCGCCTGTTTGGGTTAACAAAGCCAAAGGAAAAGAAGGAGAAAAAAAAGAAGAACAAAACCAGCCGCTCTCAGCCCGG TGATGGTCCCGCGTCAGAAGTATCAGCAGAGGGTGAAGAGATCTTCTGCTGACCCTCTTCCTCTCTGCTGAGGCAGCTGCCTCCTGATCCTGGCCAGCCC ACCTCTCCTGCTGTCCCCGCGTGCACAAGTCTCTTACACTGGACGCCCACTGCTCCTCAGCGTCCAGTCCTCCTGGGCGGCCCCAGGTCCTGGACAATAA GCAACAGATGATATTGAGTGTCGGGTGGGGAAGGAGGCCCAGACTCTGCTTCGGCCATGATTTGTGACTGCCCAGGACTCTCAGGTTGGGCTGGCCCTAC TCAGGATTACACTGAAAGTAATGGCCTCGTAAGTACAGGTGATGGTTTTGGACACGTCAGGAATTCCTAAAGGCTGAAAGAGTGTATCCAAGTAAGGTCT GAACCTCCGAATGCCTTTTATTTGGGGGAACACAAAACCAAACAGCAGATGTTTTGGACTTGATCTGTGTACGTACATGGGGACCTGTCTGCATATACAC ACGGGGAATGCCAGAAGAAGGCCCAGTCTGCACCAGGCGTCTGGTCAACTTAGCACAAGGGCAGTGCCTGGACGGACCCGGAGCCCCCGCATATCAGCAG TTCACCCAGTACTCCTCAGAGACTGGTTTCCCTCTAAACCCATCCCGGGCACATACCACCCGTGTTTTGCATGTATTTCTCATTTCATTTTAGGGATGAC AAACATTTGTGAAACCAGTGAGAGAAGGCTTGATGTGTATAAAAGACGTGATGTGCACCACCTCGATCTCGGTGTTTCAGGCACTAAAGCAACAAAACAA CCCATAGTATCTCATTCTGTCATCAGATCCAGAAGAAATATCCTGGTTTTCCAGCATGTTTACCCACATGTTTTGGCCATGGATAAAGTGAAGAGGCCTA CTCACCATTATCCCTGCAGCGTGACACCTTTTGATTGTCACTGACCACTCAGAAGGGGCCACGGCCTCCTGGCTGTGTTCCTGAGCCCCCGTCGTGCCTC TCCCAGACAGCAGCTGTCTGGCCCTTGCTGGGTGAGGGCACACCACTGCCAGGGGTCAGCCTCGCACCCAGGCCAGGCAGAAGCTGTGCTCTGAAGCTAG GACAGCTGGCTGAGAAGTGGGTTCAGGCGAAGGGTGAAGCCATGTGTAGCAGTTCCTGCCAGTGCAGATCTGGAGAGGAGCTGGCCCGGAAGGCGTGGTT GTGAAAGCGCCCTTCTTATGTTAGGAGGCCTTGGCAAAATTGGATTTCTTCAAAAATACATGTAAAGGTCTGTTGTTGAATTGTACTCTGCCCCTGGAAG CAGATACAGATGGCTGCCTGCTGCTCGGCTTTGCTTTTGCTTTTCCCACCGTGTTTTCATCTTTGTTCACTTGAGGCTTTCCCCAGCTGGTGTGTGCAGG ACAGTTCATGGTAATGTTGCCCTCTGAGGCCCCGTACACCAGAAGGGAGGCCCTGGAAAATTTTGTGCTTCCAACGTGGCCTTCAATTCTTGCTTTTTTG CCCCTCGGAAGCATGGGGCTTTTGAGCACACTTAAAAAAAGAAAAATCTGTAACTTGGTGCTTATTGATGAATTGCAAGCTGGCCTTGCAGATGGAGATA TTTATCTTTCAGTTTATTTGAAAGAGGTCTGGTTTAAAATTTGTAGCCTACATTTGTTTTATTTATTGTATTTGTGTGTTTGTGTTTGTTTTTTTTTAAG GGTGAGCCAGGTCTAGCCCAACAGTCTAAACTATCCAGTCAATACCGAGTGAAGTGGCAGCCAGCACTGTTCACTCTGTGTCTTTTGAAGTGCCTTGAAG GCCCAGATGAAATTTTAAAGGGAGGGGGTCCATGTCCTTCCCTCCCCCACCCCGCCTCATTCTTTAATCAAAGGATGTCTTCTCCCTTGTTTGAGAATGA AGAAACTCGCCACCTCTGACCTACCTTTGCCTTTTTCTGTCATGGAGAATACTCACCCTTCAGAAACAGACCAAAGGCCAAAACCTGCTGATTTTTCTAT TGAAAATATGTCCCCTTGCAAAGACCCTAAACAAAAAGTTAAGTTTCTTTCTTTCACCTATTTGTACAACTCCAAGTTACAGCTGAATCTGTCGTGACTT TCCTGAGATCTACCCGGGGCTTGGCTGTCTGTTCTGGGCACTGGCTCCGAGTTCCCCTCCTGGGATTTGCAGGAGGGCAGTACTGAACCTGCATTCTTCT CCTTGTAAATGTAGGCCGGGTGCCCCTGTTCTCCGGGTTTGGAACAATACGAGGTTGGTGCTGATGGGATTTACTTGCGTACGTGCTCTTCACAAAAACA CCGTGGATGCTGAAGTTAGAGCACGTCGCCACAGAGCTTGACATCAATGTTAGAGGGTCTCTTACTCCCCGCCCAGCTGTGATGTTTCATCTGCTTTGGT TGTTTTGGTGGTCTTTTTTAAAAATAGAGATTTCACATCTGCCCAGACCCCACTCAAAACGATTTGGTCAGGTTCTGGTTGGACAAGTTTAAAATCAAAG TAGTGCCCGGAATTCCCTCAAACCACCCAACTTCATCCAGGAATACAGTCTGCAGTGCAGCAACAGAACCGCTTACCAAGAACTGTGCTTACATACCTTT GTCATCTCTCTTCCCCCCTTGGAAGTTGTCCTCAGGGGGATTTGTTCCTGTCCTGGGGATTTACCTGGGATGGTGGCTGCCTGTGCTTTTGCTCATGGCC TTGACAGTGCTCTAGTTGCTGGATCTAATGGCCTGTCTTGGTTTCTATCACATGAGAAGGGGTTGTTTTTTTGGGGTGACTCGGACTGAATTCCCCATAC TGTTTCCACGCCGGGACACCATGTTCTCCATCAAGCTAAAGAAATCACGTGCCTGAAACTGTGCTTAAGTTTTGGGGGAAAGATGGAGTTCCTATCCAGA GCCCCCAGATTTCCAGAATCGAGTGAGCTTCCTGGAAGGAGACTGCGTCTTCTCTCAATTCCAGTCATCTCAGTCGTTGTCGTTAGGTGACATGTGCACT TTAAATGCTCTCATCGGTTGGCTTCATTTTCAAGACAATCAAATGTATTGACTGTGTTTTCTTCTTAGAAAATGGAGAGGGTTAAAAACATGCAAACTGC CACTTTCAACCTTTGCCAGTATTCCCTCTACCCCCGTGAGAGCTATCTGGGGGGAAGAATCCTTACCAAGGTTTTTTTGGAAAGGTACGAATCTTAACTT TTTTCCCCTTCTGTGTCTCAGGGTAATACTATTCAGAGTCGCCCCTTTGCTCATTTTCTCCCGTATTTGTTACCTTCCTGAGGCCTCAGTATTAGTCGTG AGCACAAAGTTTTGAGACCTTTGGCGTTGTTTCTTGATGTGGGAGGGGAGGTGTTAGTGCATGCAAGGGTTGAACTAGATAGACCCTGCCTTAGTAGAGG GTGGGACTATAACCTTAGAGGCCAGAACTTGATCCAGAAGTTGCTGTCCACAGAAGTGCTTTCTATTTCATCATTTTTGTTTCTAGGGCTCTTTTTCTGT AGCCAGGTCTTCCCAAGGATTTTAGTATTTGCATTGGAGTTGAGGTTTACTCTAATGATGGTGGCCCAGCTGTGCCCAGAGGACAGCCAGGCAGGCCCTG GGAGGGAGTTTAGAAAGACAGTCCTGGTGAATGGGCTTCAAGTGGTCACAAAGAGGGTGGCTGTGAGGTGACCCCAGACACTGCAGAACGATGTGCACCC TCTGCGTTTTGGATGTCCTTGGAATGTGGGAGCCTAGAAATAACCCTGTGGATGGAATTGGGGCAGCGGCTGCTGGAGATCTGTGTGCCTTGCCTTCCTT CAGCAGGACCGTCTAGGTGCGCAGCCACCTATGGATGCGTCCCAGCCAGCCCCGTCGCTCTCGTCCATCCTCAGAGACAAAGAAGAGGGCAGGGAGTTTG GGCTTGGTTTTGAACTTTCCTTTCAATGTAGCAAAGCATTCCTAGTTAACCAGAGCCTTGGAATCTACTGCCTGCTGGCCAGGCTTTAAAATGAAAAGTG TTTTAATGCTGCCATAAAAGGGAGGCGGGGGGGAGGAAGGGAAAATAAAGGCATCTTTCCAAGTACTCATCTAATTTAATTGTCAAAAGATTGATAGGCC ATGAATTACTTCTCCATCTCACTAAGGGTTAAAGGCGTGCAACCCCCCACTGGCTGTGTCCCCTGCCACCGAAGTGAGTGACCTGCCCTACAACCAGGTG GGACCACCTGTGCTGCAGTCCGGAGGGGCTTCTGCAGGAAGCACTCACCCCCCACACCTTCCCCGGCCTGAGCTTCCCCTACCTTTCGTCACCACCTGAG GGCATGAGCACAGGCCATGGGGCGTGCCTGGTGAGTCTGCCTGTGGTTCAGGCTTAGCCTGTGGTCTCCTGTGTGCTGCTGCCCGCATGGGATGCGCAGG GGAGGCGTGGGGATCCGCAGGAGGGTGGTTGGGATACACCGGATACCTCTGCTCTCATTGCTTGTTTGCAAATGCTCTATGGACATTTGTGTGCTAAATC CTATTAAATAAAAAAGACGGGTTAAAACCCAGATGCTGTATATTCATTTGTAATTATGTATAAAGTGAAGCAGTTTTAAACTGTAAAGATTTTTTTCAGT GTGTTTTCTCGAATTTTGCCACAACATACTGGCTTCGTATTTTATTTATCTTTCTTTCTAGTTACCAGCTTCAGACCCTTGTAAAGTCTCCCTCAGCCCT TTCAAAAAATAATAAATTTCCTGTGAAGTTCTGG

AKAP13-F1 (forward primer)
AKAP13-R1 (reverse primer)
Multiple exon skipping

Frame 0

AKRANPHPFVLQLETINFVQTLHVNRTQ*LLVA IWLQNCVIT*LASPKAPQQGNPAHKIHPMPPTVK THRLIQSPLTL*GIPRNVRIFVLSKWWITKANE KM*N*INL*QICLRWFHIHIQLSLKWRKNWCQT RQ*YQTVLSLWQTVQAVNQ*PRMTHFLLSPPRKK REQQLLNYIQLQIIEMAQMEIRMSLIRGH*KTG Q*ACPHPPLLQSFSTGWGIPVSQDLVESMRVPP LQQSQKL*ISRGTLTLPCKVWVRPLWL*IQF*LK KENFWWFQKALQLRNKIRIKR*PVPLLRKMLSL QELCRKSREHHLLDKILNNFMKNQSQLTVPRTK HFS*VIHRVHPLPFLRQKLNITRKWPHKSHC*LK VGLPRAWCHQEQVWPQSQGRKPWGQSTTAPLCC HVCCQMGLMGPMLLTAVSLLLWMLE*RTLNPRE KLVPVR*VEM*RWMLQGLMLYKVWLSPEERIYHT TPKTS*FQTSC*AKRRMPF*VCQWLYRTKL*LT HRELEPQR*YLLIGRKGSWREQTTAVPWVTLRK PK*TMKHILSYCSLLPRSSPQTWSSQPMMMGPQL V*GKSCEPRLQAGKGALPLYLAWSLPRTHLCLR GQT**RRLPAV*WMLSSNKSRPLEHCLLRGRPV TCHCPALSWVLSLKD*RVLLQKK*VLSHLGRAYQ WAVLLRKPRGALQDVLLEGRSQRRSFYLSRGLS QQQKCQT*KLKMKWILEQVQFLKKWL*GA*LLH *R*SKAQ*PRR*TEKTGVQ*SHALMQHLFWLPSR AQNVRTSWMLDWAESVPQNKVYLKENLGVILTS FTHPVMTWTASSSQSQRKSIWPVISPDPVHPPM TRLHWTDILLMAVMCLSPRF*SQTGQEIGKALMD STAMGWELRVEKVRVSLLTQATWRRRRWTVSLK CLQTALS*GAPCALFLPSGGTAGGLGKMQPAMQ K*TTGVSV*KA*QEELVSETSHPHL*K*ALQMPK SSDTHSVVRNGLTLWCHFQKRIWSQTRENIGCL ISRYVTDLSSRDLITVHQPFPLH*QNPSH**QS AILDWTIHGPSTVPSTIPVLI*LRV*QKRTIISC HIAPPRKILNGRVEQKSVVHSATSRIKCLAARR AKKRKKKKIRLRRRRKILKTRRKIRRLSTGTLS VPFLLWVPSAVASV*SPSPTKMPILVQIAVLLST KAAEKV*PPVQRSK*SSPKGAFRHMTHHHCPRS L*ETSPHSPRSVLGPQSSWWMKPLPPQYLPIDD PSRVSRSPKVSPYRTLLELAMMRTCQTPGNSCLI QQTH*IKSARSMSQQNHLLMRVQT*MKDNYWET LRLSPNSWKQSLGVG**TASF*NSKRKMWSNGK K*YMS*CRQSFIMSALSRS*VVCTARG*WRICFL SSRW*KSCSPVWMS*SVSIANSSRGFWSGRRSL WWIKVKRTFSSRG*GMCL*ISFQVRMQNV*RRH MASFVGNITSL*TTSKTFMPRISVFKPL*RRR*A VQLLEGLEFQSAYCL*LSGLPSTQFYSKEYCSV PKTMKWSRKI*HSP*AW*RM*LEL*TAKWQVMK RKCVSMRFIQRQIASQS*G*RVVRCLPRKI*NGR SLYVMGVCF*RMQQEG*KRFKQFFSLTF*FSFK KKTRSTSLHHWTRSQQ*SL*RS*L*EKWHMRRK VYS*SAWG*QIQRW*KSMPAPKRNETAGFRSFRT QSTP*TEMKMKEFLVRMRKKRKCWTPEPEN*KN NFTRRTKKSYSCWKRRR*FSGTWLSAAPLSQRI APQHIALEFSSAPTQKRLSKEDL**KVQ*MRWRS FRVW*VEIWEAHLGRLSAAPLSKMWSVPFPCPG EQRPLEDLTAIR*MLQKEARRKREMMAKILGER NQIVA*KRVEMLTWYLCLKETVSRLSRALFISTS SSALCRVWCCSRTATLRTRNWC*ARGRSLAACP ARAPSLSRRSSAAWRSSARTWPTCRSSRPSTSR RSAGASVSGKLVRGSCGSGRPSWPSARRRCSRGS RTWKRSGRSSSRRRAHTSMTWSDCVLPRNSLRG NRSSCAGRQSGSASGRQNGTCVRFPIHIPS**G SHRSSPVLRSPPRHLHLP*PNQGHWTQNFQCPQK GTASLGHTKIRGLFTY*VQPARQTKDQKGRARP LRPPLPLPACLG*QSQRKRRRKKRRTKPAALSP VMVPRQKYQQRVKRSSADPLPLC*GSCLLILASP PLLLSPRAQVSYTGRPLLLSVQSSWAAPGPGQ* ATDDIECRVGKEAQTLLRP*FVTAQDSQVGLAL LRITLKVMAS*VQVMVLDTSGIPKG*KSVSK*GL NLRMPFIWGNTKPNSRCFGLDLCTYMGTCLHIH TGNARRRPSLHQASGQLSTRAVPGRTRSPRISA VHPVLLRDWFPSKPIPGTYHPCFACISHFILGMT NICETSERRLDVYKRRDVHHLDLGVSGTKATKQ PIVSHSVIRSRRNILVFQHVYPHVLAMDKVKRP THHYPCSVTPFDCH*PLRRGHGLLAVFLSPRRAS PRQQLSGPCWVRAHHCQGSASHPGQAEAVL*S* DSWLRSGFRRRVKPCVAVPASADLERSWPGRRG CESALLMLGGLGKIGFLQKYM*RSVVELYSAPGS RYRWLPAARLCFCFSHRVFIFVHLRLSPAGVCR TVHGNVAL*GPVHQKGGPGKFCASNVAFNSCFF APRKHGAFEHT*KKKNL*LGAY**IASWPCRWRY LSFSLFERGLV*NL*PTFVLFIVFVCLCLFFFK GEPGLAQQSKLSSQYRVKWQPALFTLCLLKCLE GPDEILKGGGPCPSLPHPASFFNQRMSSPLFENE ETRHL*PTFAFFCHGEYSPFRNRPKAKTC*FFY *KYVPLQRP*TKS*VSFFHLFVQLQVTAESVVT FLRSTRGLAVCSGHWLRVPLLGFAGGQY*TCILL LVNVGRVPLFSGFGTIRGWC*WDLLAYVLFTKT PWMLKLEHVATELDINVRGSLTPRPAVMFHLLW LFWWSFLKIEISHLPRPHSKRFGQVLVGQV*NQS SARNSLKPPNFIQEYSLQCSNRTAYQELCLHTF VISLPPLEVVLRGICSCPGDLPGMVAACAFAHG LDSALVAGSNGLSWFLSHEKGLFFWGDSD*IPHT VSTPGHHVLHQAKEITCLKLCLSFGGKMEFLSR APRFPESSELPGRRLRLLSIPVISVVVVR*HVH FKCSHRLASFSRQSNVLTVFSS*KMERVKNMQTA TFNLCQYSLYPRESYLGGRILTKVFLERYES*L FSPSVSQGNTIQSRPFAHFLPYLLPS*GLSISR EHKVLRPLALFLDVGGEVLVHARVELDRPCLSRG WDYNLRGQNLIQKLLSTEVLSISSFLFLGLFFC SQVFPRILVFALELRFTLMMVAQLCPEDSQAGP GREFRKTVLVNGLQVVTKRVAVR*PQTLQNDVHP LRFGCPWNVGA*K*PCGWNWGSGCWRSVCLAFL QQDRLGAQPPMDASQPAPSLSSILRDKEEGREF GLGFELSFQCSKAFLVNQSLGIYCLLARL*NEKC FNAAIKGRRGGGRENKGIFPSTHLI*LSKD**A MNYFSISLRVKGVQPPTGCVPCHRSE*PALQPG GTTCAAVRRGFCRKHSPPTPSPA*ASPTFRHHLR A*AQAMGRAW*VCLWFRLSLWSPVCCCPHGMRR GGVGIRRRVVGIHRIPLLSLLVCKCSMDICVLN PIK*KRRVKTQMLYIHL*LCIK*SSFKL*RFFSV CFLEFCHNILASYFIYLSF*LPASDPCKVSLSP FKK**ISCEVL

Frame 1

PKGQILTHLFYNWRR*TLCRLCMSTEHSDF*WR FGCKTV**HS*RVRKHHSKATQLTRSTRCLPL* RPTGSYSHL*PCKGYPGTCGFLSFQSGG*QRPTK RCETR*TFNKYA*GGFTSTSSCP*NGERTGARP GSNIRQYFLSGKQSRQ*ISNQG*RTFFCPLPER KGNSNS*TTYSYRL*RWPRWKFE*A*YAATRRQG SRPVHILHCCRASARDGEYQSHRTWWRA*GSRP SSNPRSSEYQGEH*LFPAKCG*GHFGFRFSFD* RRKTSGGFRKLCSSGTR*G*SGDLFLY*GKCSLF RNFAGRAENTTSWTRYSTIS*KINLS*LCQGQS TSAK*FTGCILCLS*GRN*T*QGSGPTSLTADS RWGCPEPGATRSKSGHRVKAGSLGGRAQQLRSVA MSVARWV*WVRCS*LQSAFSSGCWSEEHSIPGK N*CL*GEWRCDGGCYRG*CSTRYG*AQKREYIT QHPRHPDSKRLVEPREECRSRFASGSTGQSCD*P TGSWNPRDDTS*LGEREAGGSRPQLYHG*R*GS PNRR*STSCPTAACCQGAPHRHGALSP**WGPS WCEGSHASPAFRQGKEHSLSTLHGLCPGRTSA*G GRLDRGGCQPYSGCCHRTSQGRWSTAY*GGGLS HVTVQP*VGSSH*RTRECFYRKSEYFPTWGEPT NGQYS*GSHGEPCRMFCWKGGAREDHFTCPGA*A SSRNARRES*R*SGF*SKFNF*RSGCREHSCYT EDEARPNDPGDKPRKLVYNRAMP*CSISSGFQA EPRM*ELPGCWTGQRVYLKTRCT*KRIWE*F*PL SLTQ**HGQHHLPKARGRAFGL*YHRIQFIHR* HGFTGPTFFSWQ*CVSLPDFKAKQVKRSAKP*W ILQPWDGS*GSRK*E*AC*PRRRGGGGDGQYH*S ACKLLCPKELHALSFSLPEAQLGAWEKCSQRCR NEPPEFQSRRLDRRSWCRKQAILISRSKLCKCR RAQTPIQW*GTG*LFGVTFRRGSGVRPERT*DV* SADMSQI*AAGI*LLYISHFLSIDKIHLINDNQ PSWIGQFTALPQYLPQYQC*SD*EYNRREL*FP AT*PLQERF*MEEWNKSQSYIQLHQE*NV*QQEE QRKGKRKR*D*GEGERF*RQGER*EDCQRAHFQ FHSCCGSHQL*PVYEALHQQRCLYLCKLQCFCP QRLPRKSSLLCKGQNEAAQREPSGT*HIITAHGH YEKQALTAQGASSVRSPPGG*NRYHPNICQ*TI PAECLALQKCLHTEHYWSWQ**EHVKHLEIPVS FNRLTK*NQQGQ*VNRITY**GYRHE*RTTTGRL *D*VQTAGSRVLESDNRQQVSKTAKERCGQTAR SNI*VDADRVSSCPHSQDHEWCVQPGDDGGSAF *AADGRKAVPLFG*ADQYP*PILPEDSGAEEGVS GG*K*KELSHQEDRGCACKSVFR*ECRTFKEDI WQVLWAT*PVCKLLQRPLCQG*AFSSLCKEEDE QFSC*KAWNSRVHIACNSADYQVPSFIPKNIAVY QRQ*SGAGRSSTVLEPGEGCDWSCRQQSGKL*K ESASQ*DLYKDR*QVNHEDEEWSDVCQGRFETE EACT*WECVSEECSRKVERGSSSSSH*HFSFPSR KRPEVHLCIIGPEVNSDLFKEADCERSGT*GER FIPDQHGDDRSRDGRSPCQLQRGTKQLDSDHSG HNQHPEQR*R*RNS**E*GRKENVGHQSPRIKRT TSPEGPKNPTLVGREGDDFPGHG*VQHPSPRGL LPNT*P*SSLPLQHRRGSQRRTFNEKCNK*GGD PSGFGEWKSGRHTWADCQQPH*ARCGRSRFPAPE SRDLWRI*QPSDECFKRRREGRGR*WPRS*ENG IR*WPKKGWKC*PGIYA*KKQ*AGCPERCSSLR APQRSAGCGAAAGQLH*GPETGAEREGAHSQLVP PELPH*AGEAAQPGEAAPGPGQPAEAAGPVPRG EAQARA*VGSS*EGAAGAGGPPGPARGGGAAGA AGPGKGAGGAPAEEGHIPV*PGATACCPETA*EG TGAAAPGGRAAQPAADRTGPVSGFPSTYQADED PIVLPQS*GAPLAICTFHSQIRVIGLRTFSVPK KEQHLSDTQR*GAFSHTEFNQPDKQRTRRAEPGP CVHLCLYPPVWVNKAKGKEGEKKEEQNQPLSAR *WSRVRSISRG*RDLLLTLFLSAEAAAS*SWPA HLSCCPRVHKSLTLDAHCSSASSPPGRPQVLDNK QQMILSVGWGRRPRLCFGHDL*LPRTLRLGWPY SGLH*K*WPRKYR*WFWTRQEFLKAERVYPSKV *TSECLLFGGTQNQTADVLDLICVRTWGPVCIYT RGMPEEGPVCTRRLVNLAQGQCLDGPGAPAYQQ FTQYSSETGFPLNPSRAHTTRVLHVFLISF*G* QTFVKPVREGLMCIKDVMCTTSISVFQALKQQNN P*YLILSSDPEEISWFSSMFTHMFWPWIK*RGL LTIIPAA*HLLIVTDHSEGATASWLCS*APVVP LPDSSCLALAG*GHTTARGQPRTQARQKLCSEAR TAG*EVGSGEG*SHV*QFLPVQIWRGAGPEGVV VKAPFLC*EALAKLDFFKNTCKGLLLNCTLPLE ADTDGCLLLGFAFAFPTVFSSLFT*GFPQLVCAG QFMVMLPSEAPYTRREALENFVLPTWPSILAFL PLGSMGLLSTLKKRKICNLVLIDELQAGLADGD IYLSVYLKEVWFKICSLHLFYLLYLCVCVCFFLR VSQV*PNSLNYPVNTE*SGSQHCSLCVF*SALK AQMKF*REGVHVLPSPTPPHSLIKGCLLPCLRM KKLATSDLPLPFSVMENTHPSETDQRPKPADFSI ENMSPCKDPKQKVKFLSFTYLYNSKLQLNLS*L S*DLPGAWLSVLGTGSEFPSWDLQEGSTEPAFF SL*M*AGCPCSPGLEQYEVGADGIYLRTCSSQKH RGC*S*STSPQSLTSMLEGLLLPAQL*CFICFG CFGGLF*K*RFHICPDPTQNDLVRFWLDKFKIK VVPGIPSNHPTSSRNTVCSAATEPLTKNCAYIPL SSLFPPWKLSSGGFVPVLGIYLGWWLPVLLLMA LTVL*LLDLMACLGFYHMRRGCFFGVTRTEFPI LFPRRDTMFSIKLKKSRA*NCA*VLGERWSSYPE PPDFQNRVSFLEGDCVFSQFQSSQSLSLGDMCT LNALIGWLHFQDNQMY*LCFLLRKWRGLKTCKL PLSTFASIPSTPVRAIWGEESLPRFFWKGTNLNF FPLLCLRVILFRVAPLLIFSRICYLPEASVLVV STKF*DLWRCFLMWEGRC*CMQGLN*IDPALVE GGTITLEART*SRSCCPQKCFLFHHFCF*GSFSV ARSSQGF*YLHWS*GLL**WWPSCAQRTARQAL GGSLERQSW*MGFKWSQRGWL*GDPRHCRTMCT LCVLDVLGMWEPRNNPVDGIGAAAAGDLCALPSF SRTV*VRSHLWMRPSQPRRSRPSSETKKRAGSL GLVLNFPFNVAKHS*LTRALESTACWPGFKMKS VLMLP*KGGGGEEGKIKASFQVLI*FNCQKIDRP *ITSPSH*GLKACNPPLAVSPATEVSDLPYNQV GPPVLQSGGASAGSTHPPHLPRPELPLPFVTT* GHEHRPWGVPGESACGSGLACGLLCAAARMGCAG EAWGSAGGWLGYTGYLCSHCLFANALWTFVC*I LLNKKDGLKPRCCIFICNYV*SEAVLNCKDFFQ CVFSNFATTYWLRILFIFLSSYQLQTLVKSPSAL SKNNKFPVKFW

Frame 2

QKGKSSPICSTTGDDKLCADSACQQNTVTSSGD LVAKLCDNIVSESESTTARQPSSQDPPDASHCE DPQAHTVTSDPVRDTQERADFCPFKVVDNKGQR KDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQ AVISDSTFSLANSPGSESVTKDDALSFVPSQKE KGTATPELHTATDYRDGPDGNSNEPDTRPLEDR AVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAP PAIPEALNIKGNTDSSLQSVGKATLALDSVLTE EGKLLVVSESSAAQEQDKDKAVTCSSIKENALS SGTLQEEQRTPPPGQDTQQFHEKSISADCAKDKA LQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQ GGAAQSLVPPGASLATESRQEALGAEHNSSALL PCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGK TSACEVSGDVTVDVTGVNALQGMAEPRRENISH NTQDILIPNVLLSQEKNAVLGLPVALQDKAVTD PQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEA QIDDEAHPVLLQPVAKELPTDMELSAHDDGAPA GVREVMRAPPSGRERSTPSLPCMVSAQDAPLPK GADLIEEAASRIVDAVIEQVKAAGALLTEGEACH MSLSSPELGPLTKGLESAFTEKVSTFPPGESLP MGSTPEEATGSLAGCFAGREEPEKIILPVQGPE PAAEMPDVKAEDEVDFRASSISEEVAVGSIAATL KMKQGPMTQAINRENWCTIEPCPDAASLLASKQ SPECENFLDVGLGRECTSKQGVLKRESGSDSDL FHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDD TASLDRHSSHGSDVSLSQILKPNRSRDRQSLDG FYSHGMGAEGRESESEPADPGDVEEEEMDSITE VPANCSVLRSSMRSLSPFRRHSWGPGKNAASDAE MNHRSFSLEGLTGGAGVGNKPSSSLEVSSANAE ELRHPFSGEERVDSLVSLSEEDLESDQREHRMF DQQICHRSKQQGFNYCTSAISSPLTKSISLMTIS HPGLDNSRPFHSTFHNTSANLTESITEENYNFL PHSPSKKDSEWKSGTKVSRTFSYIKNKMSSSKK SKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFS SIPVVGPISCSQCMKPFTNKDAYTCANCSAFVH KGCRESLASCAKVKMKQPKGSLQAHDTSSLPTV IMRNKPSQPKERPRSAVLLVDETATTPIFANRRS QQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH STDSLNKISKVNESTESLTDEGTDMNEGQLLGD FEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQE VIYELMQTEFHHVRTLKIMSGVYSQGMMADLLF EQQMVEKLFPCLDELISIHSQFFQRILERKKES LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTY GKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMS SSVVRRLGIPECILLVTQRITKYPVLFQRILQC TKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEK KVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRK KLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ EKDQKYIFASLDQKSTVISLKKLIVREVAHEEKG LFLISMGMTDPEMVEVHASSKEERNSWIQIIQD TINTLNRDEDEGIPSENEEEKKMLDTRARELKE QLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDC SPTHSPRVLFRSNTEEALKGGPLMKSAINEVEI LQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPR RAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTE SDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYE LLSALQGVVLQQDSYIEDQKLVLSERALTRSLS RPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEE KRRREREWEARERELREREALLAQREEEVQQGQ QDLEKEREELQQKKGTYQYDLERLRAAQKQLER EQEQLRREAERLSQRQTERDLCQVSHPHTKLMRI PSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPK RNSISRTHKDKGPFHILSSTSQTNKGPEGQSQA PASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPG DGPASEVSAEGEEIFC*PSSSLLRQLPPDPGQP TSPAVPACTSLLHWTPTAPQRPVLLGGPRSWTI SNR*Y*VSGGEGGPDSASAMICDCPGLSGWAGPT QDYTESNGLVSTGDGFGHVRNS*RLKECIQVRS EPPNAFYLGEHKTKQQMFWT*SVYVHGDLSAYT HGECQKKAQSAPGVWST*HKGSAWTDPEPPHISS SPSTPQRLVSL*THPGHIPPVFCMYFSFHFRDD KHL*NQ*EKA*CV*KT*CAPPRSRCFRH*SNKT THSISFCHQIQKKYPGFPACLPTCFGHG*SEEAY SPLSLQRDTF*LSLTTQKGPRPPGCVPEPPSCL SQTAAVWPLLGEGTPLPGVSLAPRPGRSCALKL GQLAEKWVQAKGEAMCSSSCQCRSGEELARKAWL *KRPSYVRRPWQNWISSKIHVKVCC*IVLCPWK QIQMAACCSALLLLFPPCFHLCSLEAFPSWCVQ DSSW*CCPLRPRTPEGRPWKILCFQRGLQFLLFC PSEAWGF*AHLKKEKSVTWCLLMNCKLALQMEI FIFQFI*KRSGLKFVAYICFIYCICVFVFVFF* G*ARSSPTV*TIQSIPSEVAASTVHSVSFEVP*R PR*NFKGRGSMSFPPPPRLIL*SKDVFSLV*E* RNSPPLTYLCLFLSWRILTLQKQTKGQNLLIFL LKICPLAKTLNKKLSFFLSPICTTPSYS*ICRDF PEIYPGLGCLFWALAPSSPPGICRRAVLNLHSS PCKCRPGAPVLRVWNNTRLVLMGFTCVRALHKN TVDAEVRARRHRA*HQC*RVSYSPPSCDVSSALV VLVVFFKNRDFTSAQTPLKTIWSGSGWTSLKSK *CPEFPQTTQLHPGIQSAVQQQNRLPRTVLTYL CHLSSPLGSCPQGDLFLSWGFTWDGGCLCFCSWP *QCSSCWI*WPVLVSIT*EGVVFLG*LGLNSPY CFHAGTPCSPSS*RNHVPETVLKFWGKDGVPIQ SPQISRIE*ASWKETASSLNSSHLSRCR*VTCAL *MLSSVGFIFKTIKCIDCVFFLENGEG*KHANC HFQPLPVFPLPP*ELSGGKNPYQGFFGKVRILT FFPFCVSG*YYSESPLCSFSPVFVTFLRPQY*S* AQSFETFGVVS*CGRGGVSACKG*TR*TLP**R VGL*P*RPELDPEVAVHRSAFYFIIFVSRALFL *PGLPKDFSICIGVEVYSNDGGPAVPRGQPGRPW EGV*KDSPGEWASSGHKEGGCEVTPDTAERCAP SAFWMSLECGSLEITLWMELGQRLLEICVPCLP SAGPSRCAATYGCVPASPVALVHPQRQRRGQGVW AWF*TFLSM*QSIPS*PEPWNLLPAGQALK*KV F*CCHKREAGGRKGK*RHLSKYSSNLIVKRLIG HELLLHLTKG*RRATPHWLCPLPPK*VTCPTTRW DHLCCSPEGLLQEALTPHTFPGLSFPYLSSPPE GMSTGHGACLVSLPVVQA*PVVSCVLLPAWDAQ GRRGDPQEGGWDTPDTSALIACLQMLYGHLCAKS Y*IKKTG*NPDAVYSFVIMYKVKQF*TVKIFFS VFSRILPQHTGFVFYLSFFLVTSFRPL*SLPQP FQKIINFL*SS

Sequence AKAP13.fAug05

GTTCCATCTGTGGGTAACCATGTTCCGAGGCAGCAAAGAGAAACCGCTATTGCTCCGTGGAAATAAACTATCTGAATAAAACTTCTTAACGGGGGTTGAG GCTGAAGCTGAAACGGGAGTCGGACACGATCTTGGCTCCTGAAGTCTTTAAAGGTCAGTTTGATGCACACTTCTATACCACCACCTGTTACCAGCTGTAG ACAGAAGACCTATCTCCATGCTTGCCCCTAGGCTTTTGTAGAAATGCCAGACGTGAAAGCTGAAGATGAAGTGGATTTTAGAGCAAGTTCAATTTCTGAA GAAGTGGCTGTAGGGAGCATAGCTGCTACACTGAAGATGAAGCAAGGCCCAATGACCCAGGCGATAAACCGAGAAAACTGGTGTACAATAGAGCCATGCC CTGATGCAGCATCTCTTCTGGCTTCCAAGCAGAGCCCAGAATGTGAGAACTTCCTGGATGTTGGACTGGGCAGAGAGTGTACCTCAAAACAAGGTGTACT TAAAAGAGAATCTGGGAGTGATTCTGACCTCTTTCACTCACCCAGTGATGACATGGACAGCATCATCTTCCCAAAGCCAGAGGAAGAGCATTTGGCCTGT GATATCACCGGATCCAGTTCATCCACCGATGACACGGCTTCACTGGACCGACATTCTTCTCATGGCAGTGATGTGTCTCTCTCCCAGATTTTAAAGCCAA ACAGGTCAAGAGATCGGCAAAGCCTTGATGGATTCTACAGCCATGGGATGGGAGCTGAGGGTCGAGAAAGTGAGAGTGAGCCTGCTGACCCAGGCGACGT GGAGGAGGAGGAGATGGACAGTATCACTGAAGTGCCTGCAAACTGCTCTGTCCTAAGGAGCTCCATGCGCTCTCTTTCTCCCTTCCGGAGGCACAGCTGG GGGCCTGGGAAAAATGCAGCCAGCGATGCAGAAATGAACCACCGGAGTTCAATGCGAGTTCTTGGGGATGTTGTCAGGAGACCTCCCATTCATAGGAGAA GTATGAGCTGGTGCCCCTCTGGTGTGCAGTACTCTGCTGGCCTGAGTGCTGACTTTAATTACAGAAGTTTCAGTCTAGAAGGCTTGACAGGAGGAGCTGG TGTCGGAAACAAGCCATCCTCATCTCTAGAAGTAAGCTCTGCAAATGCCGAAGAGCTCAGACACCCATTCAGTGGTGAGGAACGGGTTGACTCTTTGGTG TCACTTTCAGAAGAGGATCTGGAGTCAGACCAGAGAGAACATAGGATGTTTGATCAGCAGATATGTCACAGATCTAAGCAGCAGGGATTTAATTACTGTA CATCAGCCATTTCCTCTCCATTGACAAAATCCATCTCATTAATGACAATCAGCCATCCTGGATTGGACAATTCACGGCCCTTCCACAGTACCTTCCACAA TACCAGTGCTAATCTGACTGAGAGTATAACAGAAGAGAACTATAATTTCCTGCCACATAGCCCCTCCAAGAAAGATTCTGAATGGAAGAGTGGAACAAAA GTCAGTCGTACATTCAGCTACATCAAGAATAAAATGTCTAGCAGCAAGAAGAGCAAAGTGAGTATCACTGTGGGCATTGCTTGTGATCACCTCAGTAGGA TCCTGTCACAGCCTGCATTCACACCAAAACTGGTTAAATCATGGGGACATAAATGGAAATAAATTCAGGATTACTCTCCGAAATCGCCTAATATTTAAAG GAAAATAATAAGAAGAAAAATAGCAAGAAGTGGAACTACCAGTTACTGAGTTTTCACTATATGCTAAGTGCTTTCCATATATTATTTAACCCTTTCAACA ACCCTGTCAGGTAGGTGTTATCTCTCTTTTCTAAAAGTGATGTACCTTACCGAGGATACTCCTCTAATGTGAAGAAGTAGTTCAAACCAGATCTCTTTGG TTTCAAATCCCATACTCTTAAACCACAGTGCTTAAATCTGTAATATCAGTTTAAATGCAACAGAAGGATTTTATGCAAAGATCAAAGGATTGAAAATATT TATATTTGGCTTTAGAGGGAAGGATTATCCCACAGAAGATTACAAGAACTTTTAAGACTAATATGATTTCTTAGATCTATTTCTAATTAGGAGCATTTGG AATATATTCTCTTAGTGATTAAGAGATTAAATAAATGTTTAAACCGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTGTGTGTGTGTGTGTAAGGCTCCA CTGTATCACCCAGGCTGGAGCACAGTGGCGTGACCATAGCTCACTGCAGTCTTGAACTGCCAGGCTTAAGCAGTTTCCTGCCTCGCACCGTAGCCTCCCG AGTAGCCAGGGCTACAGTCATGTTGTGCCATCGTGCTGAGCTATGTTTAAATTTGTTTGTAAAGATGAAGTCTTGCTGTTGTGTCTAGGCCGGTCTAATG CCTTACCTCAAACACTCTTCTCGCTGCAGGCTTCCGAAGCCCTGGGTGTGATCCACCGTGCCCAGCCTAAAGTAACATTTTTTATCTAATTATTTTTCAC ATGCTCATTATGGAAATCTTCAAAATCTAAAAGTAAAAGAATGAAAATCTCCTGGAATAACCCCGCTTAGAGATAACTACACTTAATGTTTTGGTTTATA TATTTCTAATCTTTTTTAAAAATGTATTTTCAAAAGAAAGGGAGAAAAGAAGTTCACTTTCTTATACTGATTCCCAGTGCTAAACCAAAACTGATTCCAT TTCAAGTCCGTGGGGAAAAACTTTTCGCCTCTCACACCCTGTTCATCTACCCACAACACCCTCTAACAAAATAAAGACATAAGTAAATAAAAATTTGAAA TCAGTTAAGGAACTCTTGCAAGGAATCACTGTGTGTGTGTGTGTGTGTGTATGTGTGTGTGTGCACGTGCATGCATGTGTGTGTGTGTGTGGTATATACA TGTACATACAGATATATACACACGTAGATACATGCATATTTAGAAGTAAGGGAATAAACAAACATTGAATTCAAGAATATTGTCATAAAAGGGCATTGCC TCCTCCCTCACAAAACAAGGTGCACTAAGCTTCTCAAGCCCTCACTTCAGTGGGCTGATGGAAATATAGCCAAAGTATTTTACCATGTTTTGTAAGATCT CTTGGTTTAGCAAATACATTCAAAGAAATTTTTCCACCAAACGTGCCACAAGAATTGTGTTTTCATTTCTCCTGTGCAAGTACAGAATGGAGAGAAAGTA GGCAATCAGGGAGAGATGCAAAGAGTCTAGCAAATTATTTCTAGCATAATCACACATTTAACTTCAGACTCAGCCTTGTTTTATAATTCCAAAAAAAAAA AAAATGAAGGTCAAAGAATACTGCTTTACCAGTATTCTACGTATTTACATATTGGCAGCCAGGCTTAAAATAGAGCCTTACCTTTTTTACTTACCACTGC CGGCTTGGATACTAGTTGG

AKAP13-F1 (forward primer)
AKAP13-R1 (reverse primer)
Multiple exon skipping

Frame 0

VPSVGNHVPRQQRETAIAPWK*TI*IKLLNGG* G*S*NGSRTRSWLLKSLKVSLMHTSIPPPVTSCR QKTYLHACP*AFVEMPDVKAEDEVDFRASSISE EVAVGSIAATLKMKQGPMTQAINRENWCTIEPC PDAASLLASKQSPECENFLDVGLGRECTSKQGVL KRESGSDSDLFHSPSDDMDSIIFPKPEEEHLAC DITGSSSSTDDTASLDRHSSHGSDVSLSQILKP NRSRDRQSLDGFYSHGMGAEGRESESEPADPGDV EEEEMDSITEVPANCSVLRSSMRSLSPFRRHSW GPGKNAASDAEMNHRSSMRVLGDVVRRPPIHRR SMSWCPSGVQYSAGLSADFNYRSFSLEGLTGGAG VGNKPSSSLEVSSANAEELRHPFSGEERVDSLV SLSEEDLESDQREHRMFDQQICHRSKQQGFNYC TSAISSPLTKSISLMTISHPGLDNSRPFHSTFHN TSANLTESITEENYNFLPHSPSKKDSEWKSGTK VSRTFSYIKNKMSSSKKSKVSITVGIACDHLSR ILSQPAFTPKLVKSWGHKWK*IQDYSPKSPNI*R KIIRRKIARSGTTSY*VFTIC*VLSIYYLTLST TLSGRCYLSFLKVMYLTEDTPLM*RSSSNQISL VSNPILLNHSA*ICNISLNATEGFYAKIKGLKIF IFGFRGKDYPTEDYKNF*D*YDFLDLFLIRSIW NIFS**LRD*INV*TVCVCVCVCVSVCVCV*GS TVSPRLEHSGVTIAHCSLELPGLSSFLPRTVASR VARATVMLCHRAELCLNLFVKMKSCCCV*AGLM PYLKHSSRCRLPKPWV*STVPSLK*HFLSNYFS HAHYGNLQNLKVKE*KSPGITPLRDNYT*CFGLY ISNLF*KCIFKRKGEKKFTFLY*FPVLNQN*FH FKSVGKNFSPLTPCSSTHNTL*QNKDISK*KFE IS*GTLARNHCVCVCVCMCVCARACMCVCVWYIH VHTDIYTRRYMHI*K*GNKQTLNSRILS*KGIA SSLTKQGALSFSSPHFSGLMEI*PKYFTMFCKI SWFSKYIQRNFSTKRATRIVFSFLLCKYRMERK* AIRERCKESSKLFLA*SHI*LQTQPCFIIPKKK KMKVKEYCFTSILRIYILAARLKIEPYLFYLPL PAWILV

Frame 1

FHLWVTMFRGSKEKPLLLRGNKLSE*NFLTGVE AEAETGVGHDLGS*SL*RSV*CTLLYHHLLPAV DRRPISMLAPRLL*KCQT*KLKMKWILEQVQFLK KWL*GA*LLH*R*SKAQ*PRR*TEKTGVQ*SHA LMQHLFWLPSRAQNVRTSWMLDWAESVPQNKVY LKENLGVILTSFTHPVMTWTASSSQSQRKSIWPV ISPDPVHPPMTRLHWTDILLMAVMCLSPRF*SQ TGQEIGKALMDSTAMGWELRVEKVRVSLLTQAT WRRRRWTVSLKCLQTALS*GAPCALFLPSGGTAG GLGKMQPAMQK*TTGVQCEFLGMLSGDLPFIGE V*AGAPLVCSTLLA*VLTLITEVSV*KA*QEEL VSETSHPHL*K*ALQMPKSSDTHSVVRNGLTLWC HFQKRIWSQTRENIGCLISRYVTDLSSRDLITV HQPFPLH*QNPSH**QSAILDWTIHGPSTVPST IPVLI*LRV*QKRTIISCHIAPPRKILNGRVEQK SVVHSATSRIKCLAARRAK*VSLWALLVITSVG SCHSLHSHQNWLNHGDINGNKFRITLRNRLIFK GK**EEK*QEVELPVTEFSLYAKCFPYII*PFQQ PCQVGVISLF*K*CTLPRILL*CEEVVQTRSLW FQIPYS*TTVLKSVISV*MQQKDFMQRSKD*KY LYLALEGRIIPQKITRTFKTNMIS*IYF*LGAFG IYSLSD*EIK*MFKPCVCVCVCVCLCVCVCKAP LYHPGWSTVA*P*LTAVLNCQA*AVSCLAP*PP E*PGLQSCCAIVLSYV*ICL*R*SLAVVSRPV*C LTSNTLLAAGFRSPGCDPPCPA*SNIFYLIIFH MLIMEIFKI*K*KNENLLE*PRLEITTLNVLVY IFLIFFKNVFSKEREKRSSLSYTDSQC*TKTDSI SSPWGKTFRLSHPVHLPTTPSNKIKT*VNKNLK SVKELLQGITVCVCVCVCVCVHVHACVCVCGIY MYIQIYTHVDTCIFRSKGINKH*IQEYCHKRALP PPSQNKVH*ASQALTSVG*WKYSQSILPCFVRS LGLANTFKEIFPPNVPQELCFHFSCASTEWRES RQSGRDAKSLANYF*HNHTFNFRLSLVL*FQKKK K*RSKNTALPVFYVFTYWQPGLK*SLTFFTYHC RLGY*L

Frame 2

SICG*PCSEAAKRNRYCSVEINYLNKTS*RGLR LKLKRESDTILAPEVFKGQFDAHFYTTTCYQL* TEDLSPCLPLGFCRNARRES*R*SGF*SKFNF* RSGCREHSCYTEDEARPNDPGDKPRKLVYNRAMP *CSISSGFQAEPRM*ELPGCWTGQRVYLKTRCT *KRIWE*F*PLSLTQ**HGQHHLPKARGRAFGL *YHRIQFIHR*HGFTGPTFFSWQ*CVSLPDFKAK QVKRSAKP*WILQPWDGS*GSRK*E*AC*PRRR GGGGDGQYH*SACKLLCPKELHALSFSLPEAQL GAWEKCSQRCRNEPPEFNASSWGCCQETSHS*EK YELVPLWCAVLCWPEC*L*LQKFQSRRLDRRSW CRKQAILISRSKLCKCRRAQTPIQW*GTG*LFG VTFRRGSGVRPERT*DV*SADMSQI*AAGI*LLY ISHFLSIDKIHLINDNQPSWIGQFTALPQYLPQ YQC*SD*EYNRREL*FPAT*PLQERF*MEEWNK SQSYIQLHQE*NV*QQEEQSEYHCGHCL*SPQ*D PVTACIHTKTG*IMGT*MEINSGLLSEIA*YLK ENNKKKNSKKWNYQLLSFHYMLSAFHILFNPFN NPVR*VLSLFSKSDVPYRGYSSNVKK*FKPDLFG FKSHTLKPQCLNL*YQFKCNRRILCKDQRIENI YIWL*REGLSHRRLQELLRLI*FLRSISN*EHL EYILLVIKRLNKCLNRVCVCVCVCVCVCVCVRLH CITQAGAQWRDHSSLQS*TARLKQFPASHRSLP SSQGYSHVVPSC*AMFKFVCKDEVLLLCLGRSN ALPQTLFSLQASEALGVIHRAQPKVTFFI*LFFT CSLWKSSKSKSKRMKISWNNPA*R*LHLMFWFI YF*SFLKMYFQKKGRKEVHFLILIPSAKPKLIP FQVRGEKLFASHTLFIYPQHPLTK*RHK*IKI*N QLRNSCKESLCVCVCVYVCVCTCMHVCVCVVYT CTYRYIHT*IHAYLEVRE*TNIEFKNIVIKGHC LLPHKTRCTKLLKPSLQWADGNIAKVFYHVL*DL LV*QIHSKKFFHQTCHKNCVFISPVQVQNGEKV GNQGEMQRV*QIISSIITHLTSDSALFYNSKKK KNEGQRILLYQYSTYLHIGSQA*NRALPFLLTTA GLDTSW