Sequences - Rnomics 📊 Palace

        ☰
    
        Rnomics 📊 Palace
    
                       Back to Rnomics Platform
            
                       Open Session

1 warning:

Access restricted to public data.
Please sign in at Rnomics Platform to access your data.

Navigation

Home

Sequences

Sequence ARID4B.dAug05

RBP1L1-F1 (forward primer)
RBP1L1-R1 (reverse primer)
Single exon skipping

Frame 0

Frame 1

Frame 2

Sequence ARID4B.cAug05

AAAGGGGGGGAACCTAGAGTCGGTGGGGGGGAAGCGATGTTTGCCCGTCAGTCGAGTCCGGAGTGAGGAGCTCGGTCGCCGAAGCGGAGGGAGACTCTTG AGCTTCATCTTGCCGCCGCCACGGCCACCGCCTGGACCTTTGCCCGGAGGGAGCTGCAGAGGGTCCATCGCCGCCGTCCTCTGGAGGGCAGCGCGATTGG GGGCCCGGACCTCCAGTCCGGGGGGGATTTTTCGTCGTCCCCCTCCCCCCAACCAGGGAGCCCGAGCGGCCGCCAAACAAAGGTACCAGTCGCCGCCGCG GGAGGAGGAGGAGCCGGAGCCTCTGCCTCAGCAGCCGCTGGACCCGCCGCCCTTCTTCCCCATCTCTCCCCCGGGCCTGCTGGTTTTGGGGGGGAGAAGG AGAGAGGGGACTCTGGACGTGCCAGGGTCAGATCTCGCCTCCGAGGAAGGTGCAGCTGAACCTGGTGTTTTAGAGGATACCTTGGTCCCAGAGTCATCAT GAAGGCCCTTGATGAGCCTCCCTATTTGACAGTGGGCACTGATGTGAGTGCTAAATACAGAGGAGCCTTTTGTGAAGCCAAGATCAAGACAGCAAAAAGA CTTGTCAAAGTCAAGGTGACATTTAGACATGATTCTTCAACAGTGGAAGTTCAGGATGACCACATAAAGGGCCCACTAAAGGTAGGAGCTATTGTGGAAG TGAAGAATCTTGATGGTGCATATCAGGAAGCTGTTATCAATAAACTAACAGATGCGAGTTGGTACACTGTAGTTTTTGATGACGGAGATGAGAAGACACT GAGACGATCTTCACTGTGCCTGAAAGGAGAGAGGCATTTTGCTGAAAGTGAAACATTAGACCAGCTCCCACTCACCAACCCTGAGCATTTTGGCACTCCA GTCATAGGAAAGAAAACAAATAGAGGAAGAAGATCTAATCATATACCAGAGGAAGAGTCTTCATCATCCTCCAGTGATGAAGATGAGGATGATAGGAAAC AGATTGATGAGCTACTAGGCAAAGTTGTATGTGTAGATTACATTAGTTTGGATAAAAAGAAAGCACTGTGGTTTCCTGCATTGGTGGTTTGTCCTGATTG TAGTGATGAGATTGCTGTAAAAAAGGACAATATTCTTGTTCGATCTTTCAAAGATGGAAAATTTACTTCAGTTCCAAGAAAAGATGTCCATGAAATTACT AGTGACACTGCACCAAAGCCTGATGCTGTTTTAAAGCAAGCCTTTGAACAGGCACTTGAATTTCACAAAAGTAGAACTATTCCTGCTAACTGGAAGACTG AATTGAAAGAAGATAGCTCTAGCAGTGAAGCAGAGGAAGAAGAGGAGGAGGAAGATGATGAAAAAGAAAAGGAGGATAATAGCAGTGAAGAAGAAGAAGA AATAGAACCATTTCCAGAAGAAAGGGAGAACTTTCTTCAGCAATTGTACAAATTTATGGAAGATAGAGGTACACCTATTAACAAACGACCTGTACTTGGA TATCGAAATTTGAATCTCTTTAAGTTATTCAGACTTGTACACAAACTTGGAGGATTTGATAATATTGAAAGTGGAGCTGTTTGGAAACAAGTCTACCAAG ATCTTGGAATCCCTGTCTTAAATTCAGCTGCAGGATACAATGTTAAATGTGCTTATAAAAAATACTTATATGGTTTTGAGGAGTACTGTAGATCAGCCAA CATTGAATTTCAGATGGCATTGCCAGAGAAAGTTGTTAACAAGCAATGTAAGGAGTGTGAAAATGTAAAAGAAATAAAAGTTAAGGAGGAAAATGAAACA GAGATCAAAGAAATAAAGATGGAGGAGGAGAGGAATATAATACCAAGAGAAGAAAAGCCTATTGAGGATGAAATTGAAAGAAAAGAAAATATTAAGCCCT CTCTGGGAAGTAAAAAGAATTTATTAGAATCTATACCTACACATTCTGATCAGGAAAAAGAAGTTAACATTAAAAAACCAGAAGACAATGAAAATCTGGA TGACAAAGATGATGACACAACTAGGGTAGATGAATCCCTCAACATAAAGGTAGAAGCTGAGGAAGAAAAAGCAAAATCTGGATACGATGAATGGATTAAA GCAGATAAAATAGTAAGACCTGCTGATAAAAATGTGCCAAAGATAAAACATCGGAAGAAAATAAAGAATAAATTAGACAAAGAAAAAGACAAAGATGAAA AATACTCTCCAAAAAACTGTAAACTTCGGCGCTTGTCCAAACCACCATTTCAGACAAATCCATCTCCTGAAATGGTATCCAAACTGGATCTCACTGATGC CAAAAACTCTGATACTGCTCATATTAAGTCCATAGAAATTACTTCGATCCTTAATGGACTTCAAGCTTCTGAAAGTTCTGCTGAAGACAGTGAGCAGGAA GATGAGAGAGGTGCTCAAGACATGGATAATAATGGCAAAGAGGAATCTAAGATTGATCATTTGACCAACAACAGAAATGATCTTATTTCAAAGGAGGAAC AGAACAGTTCATCTTTGCTAGAAGAAAACAAAGTTCATGCAGATTTGGTAATATCCAAACCAGTGTCAAAATCTCCAGAAAGATTAAGGAAAGATATAGA AGTATTATCCGAAGATACTGATTATGAAGAAGATGAAGTCACAAAAAAGAGAAAGGATGTCAAGAAGGACACAACAGATAAATCTTCAAAACCACAAATA AAACGTGGTAAAAGAAGGTATTGCAATACAGAAGAGTGTCTAAAAACTGGATCACCTGGCAAAAAGGAAGAGAAGGCCAAGAACAAAGAATCACTTTGCA TGGAAAACAGTAGCAACAGCTCTTCAGATGAAGATGAAGAAGAAACAAAAGCAAAGATGACACCAACTAAGAAATACAATGGTTTGGAGGAAAAAAGAAA ATCTCTACGGACAACTGGTTTCTATTCAGGATTTTCAGAAGTGGCAGAAAAAAGGATTAAACTTTTAAATAACTCTGATGAAAGACTTCAAAACAGCAGG GCCAAAGATCGAAAAGATGTCTGGTCAAGTATTCAGGGACAGTGGCCTAAAAAAACGCTGAAAGAGCTTTTTTCAGACTCTGATACTGAGGCTGCAGCTT CCCCACCGCATCCTGCCCCAGAGGAGGGGGTGGCAGAGGAGTCACTGCAGACTGTGGCTGAAGAGGAGAGTTGTTCACCCAGTGTAGAACTAGAAAAACC ACCTCCAGTCAATGTCGATAGTAAACCCATTGAAGAAAAAACAGTAGAGGTCAATGACAGAAAAGCAGAATTTCCAAGTAGTGGCAGTAATTCAGTGCTA AATACCCCTCCTACTACACCTGAATCGCCTTCATCAGTCACTGTAACAGAAGGCAGCCGGCAGCAGTCTTCTGTAACAGTATCAGAACCACTGGCTCCAA ACCAAGAAGAGGTTCGAAGTATCAAGAGTGAAACTGATAGCACAATTGAGGTGGATAGTGTTGCTGGGGAGCTCCAAGACCTCCAGTCTGAAGGGAATAG CTCGCCAGCAGGTTTTGATGCCAGTGTGAGCTCAAGCAGTAGTAATCAGCCAGAACCAGAACATCCTGAAAAAGCCTGTACAGGTCAGAAAAGAGTGAAA GATGCTCAGGGAGGAGGAAGTTCATCAAAAAAGCAGAAAAGAAGCCATAAAGCAACAGTGGTAAACAACAAAAAGAAGGGAAAAGGCACAAATAGTAGTG ATAGTGAAGAACTTTCAGCTGGTGAAAGTATAACTAAGAGTCAGCCAGTCAAATCAGTTTCCACTGGAATGAAGTCTCATAGTACCAAATCTCCCGCAAG GACGCAGTCTCCAGGAAAATGTGGAAAGAATGGTGATAAGGATCCTGATCTCAAGGAACCCAGTAATCGATTACCCAAAGTTTACAAATGGAGTTTTCAG ATGTCGGACCTGGAAAATATGACAAGTGCCGAACGCATCACAATTCTTCAAGAAAAACTTCAAGAAATCAGAAAACATTATCTGTCATTAAAATCTGAAG TAGCTTCCATTGATCGGAGGAGAAAGCGTTTAAAGAAGAAAGAGAGAGAAAGTGCTGCTACATCCTCATCCTCCTCTTCACCTTCATCCAGTTCCATAAC AGCTGCTGTTATGTTAACTTTAGCTGAACCGTCAATGTCCAGCGCATCACAAAATGGAATGTCAGTTGAGTGCAGGTGACAGCAGGACTTGCTAAAGCAC TTTGCACTTAATGGCTGTTGAGGGCCACTTTTTTTTTATACTGCACAGTGGCACAAAAAAATATCAGACAAGCACTATTTTATATTTAAAAATTGTTTCT TGACAAGCTGACTTGGCACTTAAGTGCACTTTTTTATGAAGAAAAAGTACAATGAACTGCTTTTCCTCAAGCAATAATTGTTTCCAACTTGTCTGGGAAT TGTGTGTCTGGTAACTGGAAGGCCTTCCACTGTGGCAAATGGAGGCTTTTCACTGCCTGTAGAGACAATACAGTAAGCATAGTTAAGGGGTGGGTCAGAA CATGTTAAGATAACTTACTGTATATGTATTCCCTTGTATTTTGTTAAAGCTGGAACATTTGATATTTTTCCATTTATTTATGAAAAAATATGAACCTATT TTCATTTGTACAAGGTAATTGTTTTTTAAAGCAAGTCACCTTAGGGTGGCTTTAATTGTATAAGTCAAGCACATGTAATAAATTCAAAACCTGCAGTTAA CAGGATATTAGACATCAATCCTGGTAACCAAATATTAAAGATTCTCTTTAAAAAAGACTGAACATGTTTACAGGTTTGAATTAGGCTAAAAGGTCTTGCA GTGGCTTTTCATGGCCCTTCAAATTGGAATGGAACTACTGTACTTTGCCATTTTTCTATAAATCAGTATTTTTTTTTAATTTTGATATACATTGTGTGAA AAAAGAAAATGGCTAATAAACTGTATTAAATCTTAAACAATGTATAAAGATTGTACTTAGCCAGTTCAAAGTGTATATTTATTCATAATGAATTATAACA GTTATATTTTTGTGTTTTCTTGTAAATGTTTCTTTTCCCTTAAATACAGATAATTCATTTGTATTGCTTATTTTATTATGAGCTACAACAAAAGGACTTC AGGAACAAGTAATGTATTAGTATGGTTCAAGATTGTTGATAGGAACTGTCTCAAAAGGATGGTGGTTATTTTAAATATAAATAGCTAATGGGGGTGGTAG GCCTATAAAATTAAATGCCTTGTATAAAATCCAAAATGAATGCAAAATTGTTTTCACTTGTATTGACTTTATGTTGTATGATTCCAATCTCTGTTCTGTT TGGCACTTGTATTTAATTCTTCACCTTTGTAAGACATTTGTATATTGTGGATGTGTTCATTCAAGCTATTTAATATCTGGCACTGTTAATACACAGTACT TTATTGTACAGACTGTTTTACTGTTTTAATTGTAGTTCTGTGTACTTTTTTTGGATGGGGCTGGCATGTTTTCTTTGTTTCCTGGCAATACGACGTGGGA ATTTCAATGCGTTTTGTTGTAGATGCTAACGTGTCAGAATCCTTTACATTCAACTTTTCTAAGAAAAGCATTTTCAGTCTTGTAGTGTGTGCTTACAGTA ACTAATTTTGTTGAAAATGGTTTCAAGTTATTCAAATTTGTACAGGACTGTAAAGATTTGTTGACAGCAAAATGTTGAAGAAAAAAGCTTATAGAATAAA AGCTATAAAGTATATATTAGGATCTGCAAACAATGAAGAATTATGTAATATATTGTACAAATGTAAGCAAAGGCTCTGAAATAAAATGCCATAGTTTGTG AATCCTTGATTTTTGTTTCTAAAAGATTTAGTAATTTTAGTTCATTTCTGTATGTG

RBP1L1-F1 (forward primer)
RBP1L1-R1 (reverse primer)
Single exon skipping

Frame 0

KGGEPRVGGGEAMFARQSSPE*GARSPKRRETL ELHLAAATATAWTFARRELQRVHRRRPLEGSAIG GPDLQSGGDFSSSPSPQPGSPSGRQTKVPVAAA GGGGAGASASAAAGPAALLPHLSPGPAGFGGEK ERGDSGRARVRSRLRGRCS*TWCFRGYLGPRVIM KALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKR LVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVE VKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTL RRSSLCLKGERHFAESETLDQLPLTNPEHFGTP VIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRK QIDELLGKVVCVDYISLDKKKALWFPALVVCPDC SDEIAVKKDNILVRSFKDGKFTSVPRKDVHEIT SDTAPKPDAVLKQAFEQALEFHKSRTIPANWKT ELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEE IEPFPEERENFLQQLYKFMEDRGTPINKRPVLG YRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQ DLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSAN IEFQMALPEKVVNKQCKECENVKEIKVKEENET EIKEIKMEEERNIIPREEKPIEDEIERKENIKP SLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLD DKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIK ADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDE KYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDA KNSDTAHIKSIEITSILNGLQASESSAEDSEQE DERGAQDMDNNGKEESKIDHLTNNRNDLISKEE QNSSSLLEENKVHADLVISKPVSKSPERLRKDIE VLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQI KRGKRRYCNTEECLKTGSPGKKEEKAKNKESLC MENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRK SLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSR AKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAA SPPHPAPEEGVAEESLQTVAEEESCSPSVELEKP PPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVL NTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAP NQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNS SPAGFDASVSSSSSNQPEPEHPEKACTGQKRVK DAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSS DSEELSAGESITKSQPVKSVSTGMKSHSTKSPAR TQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQ MSDLENMTSAERITILQEKLQEIRKHYLSLKSE VASIDRRRKRLKKKERESAATSSSSSSPSSSSIT AAVMLTLAEPSMSSASQNGMSVECR*QQDLLKH FALNGC*GPLFFYTAQWHKKISDKHYFIFKNCF LTS*LGT*VHFFMKKKYNELLFLKQ*LFPTCLGI VCLVTGRPSTVANGGFSLPVETIQ*A*LRGGSE HVKITYCICIPLYFVKAGTFDIFPFIYEKI*TY FHLYKVIVF*SKSP*GGFNCISQAHVINSKPAVN RILDINPGNQILKILFKKD*TCLQV*IRLKGLA VAFHGPSNWNGTTVLCHFSINQYFFLILIYIV* KKKMANKLY*ILNNV*RLYLASSKCIFIHNEL*Q LYFCVFL*MFLFP*IQIIHLYCLFYYELQQKDF RNK*CISMVQDC**ELSQKDGGYFKYK*LMGVV GL*N*MPCIKSKMNAKLFSLVLTLCCMIPISVLF GTCI*FFTFVRHLYIVDVFIQAI*YLALLIHST LLYRLFYCFNCSSVYFFWMGLACFLCFLAIRRG NFNAFCCRC*RVRILYIQLF*EKHFQSCSVCLQ* LILLKMVSSYSNLYRTVKIC*QQNVEEKSL*NK SYKVYIRICKQ*RIM*YIVQM*AKALK*NAIVC ESLIFVSKRFSNFSSFLYV

Frame 1

KGGNLESVGGKRCLPVSRVRSEELGRRSGGRLL SFILPPPRPPPGPLPGGSCRGSIAAVLWRAARL GARTSSPGGIFRRPPPPNQGARAAAKQRYQSPPR EEEEPEPLPQQPLDPPPFFPISPPGLLVLGGRR REGTLDVPGSDLASEEGAAEPGVLEDTLVPESS *RPLMSLPI*QWALM*VLNTEEPFVKPRSRQQKD LSKSR*HLDMILQQWKFRMTT*RAH*R*ELLWK *RILMVHIRKLLSIN*QMRVGTL*FLMTEMRRH *DDLHCA*KERGILLKVKH*TSSHSPTLSILALQ S*ERKQIEEEDLIIYQRKSLHHPPVMKMRMIGN RLMSY*AKLYV*ITLVWIKRKHCGFLHWWFVLI VVMRLL*KRTIFLFDLSKMENLLQFQEKMSMKLL VTLHQSLMLF*SKPLNRHLNFTKVELFLLTGRL N*KKIALAVKQRKKRRRKMMKKKRRIIAVKKKK K*NHFQKKGRTFFSNCTNLWKIEVHLLTNDLYLD IEI*ISLSYSDLYTNLEDLIILKVELFGNKSTK ILESLS*IQLQDTMLNVLIKNTYMVLRSTVDQP TLNFRWHCQRKLLTSNVRSVKM*KK*KLRRKMKQ RSKK*RWRRRGI*YQEKKSLLRMKLKEKKILSP LWEVKRIY*NLYLHILIRKKKLTLKNQKTMKIW MTKMMTQLG*MNPST*R*KLRKKKQNLDTMNGLK QIK**DLLIKMCQR*NIGRK*RIN*TKKKTKMK NTLQKTVNFGACPNHHFRQIHLLKWYPNWISLM PKTLILLILSP*KLLRSLMDFKLLKVLLKTVSRK MREVLKTWIIMAKRNLRLII*PTTEMILFQRRN RTVHLC*KKTKFMQIW*YPNQCQNLQKD*GKI* KYYPKILIMKKMKSQKRERMSRRTQQINLQNHK* NVVKEGIAIQKSV*KLDHLAKRKRRPRTKNHFA WKTVATALQMKMKKKQKQR*HQLRNTMVWRKKE NLYGQLVSIQDFQKWQKKGLNF*ITLMKDFKTAG PKIEKMSGQVFRDSGLKKR*KSFFQTLILRLQL PHRILPQRRGWQRSHCRLWLKRRVVHPV*N*KN HLQSMSIVNPLKKKQ*RSMTEKQNFQVVAVIQC* IPLLLHLNRLHQSL*QKAAGSSLL*QYQNHWLQ TKKRFEVSRVKLIAQLRWIVLLGSSKTSSLKGI ARQQVLMPV*AQAVVISQNQNILKKPVQVRKE*K MLREEEVHQKSRKEAIKQQW*TTKRREKAQIVV IVKNFQLVKV*LRVSQSNQFPLE*SLIVPNLPQ GRSLQENVERMVIRILISRNPVIDYPKFTNGVFR CRTWKI*QVPNASQFFKKNFKKSENIICH*NLK *LPLIGGESV*RRKREKVLLHPHPPLHLHPVP* QLLLC*L*LNRQCPAHHKMECQLSAGDSRTC*ST LHLMAVEGHFFFILHSGTKKYQTSTILYLKIVS *QADLALKCTFL*RKSTMNCFSSSNNCFQLVWE LCVW*LEGLPLWQMEAFHCL*RQYSKHS*GVGQN MLR*LTVYVFPCILLKLEHLIFFHLFMKKYEPI FICTR*LFFKASHLRVALIV*VKHM**IQNLQL TGY*TSILVTKY*RFSLKKTEHVYRFELG*KVLQ WLFMALQIGMELLYFAIFL*ISIFF*F*YTLCE KRKWLINCIKS*TMYKDCT*PVQSVYLFIMNYN SYIFVFSCKCFFSLKYR*FICIAYFIMSYNKRTS GTSNVLVWFKIVDRNCLKRMVVILNINS*WGW* AYKIKCLV*NPK*MQNCFHLY*LYVV*FQSLFC LALVFNSSPL*DICILWMCSFKLFNIWHC*YTVL YCTDCFTVLIVVLCTFFGWGWHVFFVSWQYDVG ISMRFVVDANVSESFTFNFSKKSIFSLVVCAYS N*FC*KWFQVIQICTGL*RFVDSKMLKKKAYRIK AIKYILGSANNEELCNILYKCKQRL*NKMP*FV NP*FLFLKDLVILVHFCM

Frame 2

RGGT*SRWGGSDVCPSVESGVRSSVAEAEGDS* ASSCRRHGHRLDLCPEGAAEGPSPPSSGGQRDW GPGPPVRGGFFVVPLPPTREPERPPNKGTSRRR GRRRSRSLCLSSRWTRRPSSPSLPRACWFWGGEG ERGLWTCQGQISPPRKVQLNLVF*RIPWSQSHH EGP**ASLFDSGH*CEC*IQRSLL*SQDQDSKK TCQSQGDI*T*FFNSGSSG*PHKGPTKGRSYCGS EES*WCISGSCYQ*TNRCELVHCSF**RR*EDT ETIFTVPERREAFC*K*NIRPAPTHQP*AFWHS SHRKENK*RKKI*SYTRGRVFIILQ**R*G**ET D**ATRQSCMCRLH*FG*KESTVVSCIGGLS*L ***DCCKKGQYSCSIFQRWKIYFSSKKRCP*NY **HCTKA*CCFKASL*TGT*ISQK*NYSC*LED* IERR*L*Q*SRGRRGGGR**KRKGG**Q*RRRR NRTISRRKGELSSAIVQIYGR*RYTY*QTTCTW ISKFESL*VIQTCTQTWRI**Y*KWSCLETSLPR SWNPCLKFSCRIQC*MCL*KILIWF*GVL*ISQ H*ISDGIARESC*QAM*GV*KCKRNKS*GGK*N RDQRNKDGGGEEYNTKRRKAY*G*N*KKRKY*AL SGK*KEFIRIYTYTF*SGKRS*H*KTRRQ*KSG *QR**HN*GR*IPQHKGRS*GRKSKIWIR*MD* SR*NSKTC**KCAKDKTSEENKE*IRQRKRQR*K ILSKKL*TSALVQTTISDKSIS*NGIQTGSH*C QKL*YCSY*VHRNYFDP*WTSSF*KFC*RQ*AG R*ERCSRHG**WQRGI*D*SFDQQQK*SYFKGGT EQFIFARRKQSSCRFGNIQTSVKISRKIKERYR SIIRRY*L*RR*SHKKEKGCQEGHNR*IFKTTN KTW*KKVLQYRRVSKNWITWQKGREGQEQRITLH GKQ*QQLFR*R*RRNKSKDDTN*EIQWFGGKKK ISTDNWFLFRIFRSGRKKD*TFK*L**KTSKQQ GQRSKRCLVKYSGTVA*KNAERAFFRL*Y*GCSF PTASCPRGGGGRGVTADCG*RGELFTQCRTRKT TSSQCR**TH*RKNSRGQ*QKSRISK*WQ*FSA KYPSYYT*IAFISHCNRRQPAAVFCNSIRTTGSK PRRGSKYQE*N**HN*GG*CCWGAPRPPV*RE* LASRF*CQCELKQ**SARTRTS*KSLYRSEKSE RCSGRRKFIKKAEKKP*SNSGKQQKEGKRHK*** **RTFSW*KYN*ESASQISFHWNEVS*YQISRK DAVSRKMWKEW**GS*SQGTQ*SITQSLQMEFS DVGPGKYDKCRTHHNSSRKTSRNQKTLSVIKI*S SFH*SEEKAFKEERERKCCYILILLFTFIQFHN SCCYVNFS*TVNVQRITKWNVS*VQVTAGLAKA LCT*WLLRATFFLYCTVAQKNIRQALFYI*KLFL DKLTWHLSALFYEEKVQ*TAFPQAIIVSNLSGN CVSGNWKAFHCGKWRLFTACRDNTVSIVKGWVR TC*DNLLYMYSLVFC*SWNI*YFSIYL*KNMNLF SFVQGNCFLKQVTLGWL*LYKSSTCNKFKTCS* QDIRHQSW*PNIKDSL*KRLNMFTGLN*AKRSC SGFSWPFKLEWNYCTLPFFYKSVFFFNFDIHCVK KENG**TVLNLKQCIKIVLSQFKVYIYS**IIT VIFLCFLVNVSFPLNTDNSFVLLILL*ATTKGL QEQVMY*YGSRLLIGTVSKGWWLF*I*IANGGGR PIKLNALYKIQNECKIVFTCIDFMLYDSNLCSV WHLYLILHLCKTFVYCGCVHSSYLISGTVNTQY FIVQTVLLF*L*FCVLFLDGAGMFSLFPGNTTWE FQCVLL*MLTCQNPLHSTFLRKAFSVL*CVLTV TNFVENGFKLFKFVQDCKDLLTAKC*RKKLIE* KL*SIY*DLQTMKNYVIYCTNVSKGSEIKCHSL* ILDFCF*KI**F*FISVC

Sequence ARID4B.eAug05

TGGGAAAATGATGTGCTTTCCTCTCATGATAAACTCTTGCTGTTATTTTTTAGAAATTTAGAAAATGATTTAAGATTTAAATTAGCCATTTTACAGGTCT TAGGAAATGTAATAAGAGTTTGGGAATACCTATATTCATCATTGGCATGCTTATTCTTTGTGAGGATAAATGGAAATATTTTATTTTTTTCTCTCCCTAG ACCAGAGGAAGAGTCTTCATCATCCTCCAGTGATGAAGATGAGGATGATAGGAAACAGATTGATGAGCTACTAGGCAAAGTTGTATGTGTAGATTACATT AGTTTGGATAAAAAGAAAGCACTGTGGTTTCCTGCATTGGTGGTTTGTCCTGATTGTAGTGATGAGATTGCTGTAAAAAAGGACAATATTCTTGTTCGAT CTTTCAAAGATGGAAAATTTACTTCAGTTCCAAGAAAAGATGTCCATGAAATTACTAGTGACACTGCACCAAAGCCTGATGCTGTTTTAAAGCAAGCCTT TGAACAGGCACTTGAATTTCACAAAAGTAGAACTATTCCTGCTAACTGGAAGACTGAATTGAAAGAAGATAGCTCTAGCAGTGAAGCAGAGGAAGAAGAG GAGGAGGAAGATGATGAAAAAGAAAAGGAGGATAATAGCAGTGAAGAAGAAGAAGAAATAGAACCATTTCCAGAAGAAAGGGAGAACTTTCTTCAGCAAT TGTACAAATTTATGGAAGATAGAGGTACACCTATTAACAAACGACCTGTACTTGGATATCGAAATTTGAATCTCTTTAAGTTATTCAGACTTGTACACAA ACTTGGAGGATTTGATAATATTGAAAGTGGAGCTGTTTGGAAACAAGTCTACCAAGATCTTGGAATCCCTGTCTTAAATTCAGCTGCAGGATACAATGTT AAATGTGCTTATAAAAAATACTTATATGGTTTTGAGGAGTACTGTAGATCAGCCAACATTGAATTTCAGATGGCATTGCCAGAGAAAGTTGTTAACAAGC AATGTAAGGAGTGTGAAAATGTAAAAGAAATAAAAGTTAAGGAGGAAAATGAAACAGAGATCAAAGAAATAAAGATGGAGGAGGAGAGGAATATAATACC AAGAGAAGAAAAGCCTATTGAGGATGAAATTGAAAGAAAAGAAAATATTAAGCCCTCTCTGGGAAGTAAAAAGAATTTATTAGAATCTATACCTACACAT TCTGATCAGGAAAAAGAAGTTAACATTAAAAAACCAGAAGACAATGAAAATCTGGATGACAAAGATGATGACACAACTAGGGTAGATGAATCCCTCAACA TAAAGGTAGAAGCTGAGGAAGAAAAAGCAAAATCTGGAGATGAAACGAATAAAGAAGAAGATGAAGATGATGAAGAAGCAGAAGAGGAGGAGGAGGAGGA AGAAGAAGAAGAGGATGAAGATGATGATGACAACAATGAGGAAGAGGAGTTTGAGTGCTATCCACCAGGCATGAAAGTCCAAGTGCGGTATGGACGAGGG AAAAATCAAAAAATGTATGAAGCTAGTATTAAAGATTCTGATGTCGAAGGTGGAGAGGTCCTTTACTTGGTGCATTACTGCGGATGGAATGTGAGATACG ATGAATGGATTAAAGCAGATAAAATAGTAAGACCTGCTGATAAAAATGTGCCAAAGATAAAACATCGGAAGAAAATAAAGAATAAATTAGACAAAGAAAA AGACAAAGATGAAAAATACTCTCCAAAAAACTGTAAACTTCGGCGCTTGTCCAAACCACCATTTCAGACAAATCCATCTCCTGAAATGGTATCCAAACTG GATCTCACTGATGCCAAAAACTCTGATACTGCTCATATTAAGTCCATAGAAATTACTTCGATCCTTAATGGACTTCAAGCTTCTGAAAGTTCTGCTGAAG ACAGTGAGCAGGAAGATGAGAGAGGTGCTCAAGACATGGATAATAATGGCAAAGAGGAATCTAAGATTGATCATTTGACCAACAACAGAAATGATCTTAT TTCAAAGGAGGAACAGAACAGTTCATCTTTGCTAGAAGAAAACAAAGTTCATGCAGATTTGGTAATATCCAAACCAGTGTCAAAATCTCCAGAAAGATTA AGGAAAGATATAGAAGTATTATCCGAAGATACTGATTATGAAGAAGATGAAGTCACAAAAAAGAGAAAGGATGTCAAGAAGGACACAACAGATAAATCTT CAAAACCACAAATAAAACGTGGTAAAAGAAGGTATTGCAATACAGAAGAGTGTCTAAAAACTGGATCACCTGGCAAAAAGGAAGAGAAGGCCAAGAACAA AGAATCACTTTGCATGGAAAACAGTAGCAACAGCTCTTCAGATGAAGATGAAGAAGAAACAAAAGCAAAGATGACACCAACTAAGAAATACAATGGTTTG GAGGAAAAAAGAAAATCTCTACGGACAACTGGTTTCTATTCAGGATTTTCAGAAGTGGCAGAAAAAAGGATTAAACTTTTAAATAACTCTGATGAAAGAC TTCAAAACAGCAGGGCCAAAGATCGAAAAGATGTCTGGTCAAGTATTCAGGGACAGTGGCCTAAAAAAACGCTGAAAGAGCTTTTTTCAGACTCTGATAC TGAGGCTGCAGCTTCCCCACCGCATCCTGCCCCAGAGGAGGGGGTGGCAGAGGAGTCACTGCAGACTGTGGCTGAAGAGGAGAGTTGTTCACCCAGTGTA GAACTAGAAAAACCACCTCCAGTCAATGTCGATAGTAAACCCATTGAAGAAAAAACAGTAGAGGTCAATGACAGAAAAGCAGAATTTCCAAGTAGTGGCA GTAATTCAGTGCTAAATACCCCTCCTACTACACCTGAATCGCCTTCATCAGTCACTGTAACAGAAGGCAGCCGGCAGCAGTCTTCTGTAACAGTATCAGA ACCACTGGCTCCAAACCAAGAAGAGGTTCGAAGTATCAAGAGTGAAACTGATAGCACAATTGAGGTGGATAGTGTTGCTGGGGAGCTCCAAGACCTCCAG TCTGAAGGGAATAGCTCGCCAGCAGGTTTTGATGCCAGTGTGAGCTCAAGCAGTAGTAATCAGCCAGAACCAGAACATCCTGAAAAAGGTGAGAAGGAAA ATGTGTATGTTGACTTATTTTAGGGTTTCCCCTCTTAAAGTTTCAATGATTTCACAGTATCTCTTGTTATAACCTGAGGCGATTAAGTGTCATATTTGTG TGAACATGGTAAAAATGGAAATTTTAAAGGTAATTTGAAAATGAATAGTGGAATGCATTTAAAAGCTTGAGAAGGCTTTAATGTGCTTTGCTTGAGCCAT CCATGGCATTTTATTGTGGACCAGAACACATGCTAGAAATTGCACCCAGGCCCAAATCCAAACCTGTTTGAGAATTCATTATATGCAGTGGTTGACTATA TGGCATGAGCAGCTTAAATCTATTTCTGTAACATTGTTTTTGCAATTGTAATGTGCAGTTTCTCACGAACATTTTGATTTATTGACAGACCCCTCCACCC TTAACCAAATACTGTATGTAGGGGTTTGGAGCAACCAACTGTCCAGGCACTGCTTTCCTCAGACAACCGTGTCAAACTGATTTTCAAGCCTGACTAACTT GTGTGAGTTTGTAAAGGAATTTGATGCTTTCTTAGATGCATAGCTTCCAAATTGAAGGACCAATGTGTACGTTAATAACCTACAGTAATACTTTTTTGAT TTTCCGTGAAATTGTTAAAAGTGGAAATTCAAATCGGTACCTTCCCAAAGTATTAGTGCCTTTCGATGGTGCCATAGCCATACTTCTGTCATCATTTTTC TTATAAACCACTTCATTCAGGTATCTTTAAATCAGTATACTCTAGGCTGACACCTGGCTTTGGAACACACTTTTCCATCGTAAAGACAGAGCACTGGAGT ATGTTTTTTATATACCGTAAAAGATTTTAGAATGCTAGCTTTAGGTTTTCAGCAAAGCTTAAAGAGATATGGTCTAGATCAAATTAGTTAATTCTATGTT TTCTCAGGAATCTTGACTTAAAACATTTCTGTTTTAAAATAAATTAAAAAAATACTTGCAATTAAATTGAAATGTTCTTTGCTTTTTTTCACATTTACAA GTATAACTACTATGATTTTATCTGTGCCATACTATCTCATGCAACTGAACTATCCAGGCATGACTAATCTTCAAAATGAAAGAATCCTTTATTTCAGAAT ATTAGGCTTTCAACAGTAAGATTTTACTGGCCAGGTGTGGTCACTCACACCTGTAATCCCAGCAATTTGGGAGGTCTGGGAGGTCAAGGCGGTGGATCGC TTGAGTCCAGGAGTTCAAGACCAGCCTGGACAACATGGCAAAACCCCATCTCTACCAAAAATACAAACGTCAGCCAGCTGTGGTGGCGCATGCCTGTAGT CCCAGCTACCTTGGGGGCTGATGAGGGAGAATCACTTGATCCCGGAAAGGCTGCAGTGAGCCAAGATCACGCCACTGCACTCCAGCCTGGGTGATAAAAC AAGACCCTGTCTC

RBP1L1-F1 (forward primer)
RBP1L1-R1 (reverse primer)
Single exon skipping

Frame 0

WENDVLSSHDKLLLLFFRNLENDLRFKLAILQV LGNVIRVWEYLYSSLACLFFVRINGNILFFSLPR PEEESSSSSSDEDEDDRKQIDELLGKVVCVDYI SLDKKKALWFPALVVCPDCSDEIAVKKDNILVR SFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAF EQALEFHKSRTIPANWKTELKEDSSSSEAEEEE EEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQ LYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHK LGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNV KCAYKKYLYGFEEYCRSANIEFQMALPEKVVNK QCKECENVKEIKVKEENETEIKEIKMEEERNIIP REEKPIEDEIERKENIKPSLGSKKNLLESIPTH SDQEKEVNIKKPEDNENLDDKDDDTTRVDESLN IKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEE EEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRG KNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRY DEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEK DKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKL DLTDAKNSDTAHIKSIEITSILNGLQASESSAE DSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLI SKEEQNSSSLLEENKVHADLVISKPVSKSPERL RKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKS SKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNK ESLCMENSSNSSSDEDEEETKAKMTPTKKYNGL EEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDER LQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDT EAAASPPHPAPEEGVAEESLQTVAEEESCSPSV ELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSG SNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSE PLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQ SEGNSSPAGFDASVSSSSSNQPEPEHPEKGEKE NVYVDLF*GFPS*SFNDFTVSLVIT*GD*VSYLC EHGKNGNFKGNLKMNSGMHLKA*EGFNVLCLSH PWHFIVDQNTC*KLHPGPNPNLFENSLYAVVDY MA*AA*IYFCNIVFAIVMCSFSRTF*FIDRPLHP *PNTVCRGLEQPTVQALLSSDNRVKLIFKPD*L V*VCKGI*CFLRCIASKLKDQCVR**PTVILF* FSVKLLKVEIQIGTFPKY*CLSMVP*PYFCHHFS YKPLHSGIFKSVYSRLTPGFGTHFSIVKTEHWS MFFIYRKRF*NASFRFSAKLKEIWSRSN*LILC FLRNLDLKHFCFKIN*KNTCN*IEMFFAFFHIYK YNYYDFICAILSHATELSRHD*SSK*KNPLFQN IRLSTVRFYWPGVVTHTCNPSNLGGLGGQGGGS LESRSSRPAWTTWQNPISTKNTNVSQLWWRMPVV PATLGADEGESLDPGKAAVSQDHATALQPG**N KTLS

Frame 1

GKMMCFPLMINSCCYFLEI*KMI*DLN*PFYRS *EM**EFGNTYIHHWHAYSL*G*MEIFYFFLSL DQRKSLHHPPVMKMRMIGNRLMSY*AKLYV*ITL VWIKRKHCGFLHWWFVLIVVMRLL*KRTIFLFD LSKMENLLQFQEKMSMKLLVTLHQSLMLF*SKP LNRHLNFTKVELFLLTGRLN*KKIALAVKQRKKR RRKMMKKKRRIIAVKKKKK*NHFQKKGRTFFSN CTNLWKIEVHLLTNDLYLDIEI*ISLSYSDLYT NLEDLIILKVELFGNKSTKILESLS*IQLQDTML NVLIKNTYMVLRSTVDQPTLNFRWHCQRKLLTS NVRSVKM*KK*KLRRKMKQRSKK*RWRRRGI*Y QEKKSLLRMKLKEKKILSPLWEVKRIY*NLYLHI LIRKKKLTLKNQKTMKIWMTKMMTQLG*MNPST *R*KLRKKKQNLEMKRIKKKMKMMKKQKRRRRR KKKKRMKMMMTTMRKRSLSAIHQA*KSKCGMDEG KIKKCMKLVLKILMSKVERSFTWCITADGM*DT MNGLKQIK**DLLIKMCQR*NIGRK*RIN*TKK KTKMKNTLQKTVNFGACPNHHFRQIHLLKWYPNW ISLMPKTLILLILSP*KLLRSLMDFKLLKVLLK TVSRKMREVLKTWIIMAKRNLRLII*PTTEMIL FQRRNRTVHLC*KKTKFMQIW*YPNQCQNLQKD* GKI*KYYPKILIMKKMKSQKRERMSRRTQQINL QNHK*NVVKEGIAIQKSV*KLDHLAKRKRRPRT KNHFAWKTVATALQMKMKKKQKQR*HQLRNTMVW RKKENLYGQLVSIQDFQKWQKKGLNF*ITLMKD FKTAGPKIEKMSGQVFRDSGLKKR*KSFFQTLI LRLQLPHRILPQRRGWQRSHCRLWLKRRVVHPV* N*KNHLQSMSIVNPLKKKQ*RSMTEKQNFQVVA VIQC*IPLLLHLNRLHQSL*QKAAGSSLL*QYQ NHWLQTKKRFEVSRVKLIAQLRWIVLLGSSKTSS LKGIARQQVLMPV*AQAVVISQNQNILKKVRRK MCMLTYFRVSPLKVSMISQYLLL*PEAIKCHIC VNMVKMEILKVI*K*IVECI*KLEKALMCFA*AI HGILLWTRTHARNCTQAQIQTCLRIHYMQWLTI WHEQLKSISVTLFLQL*CAVSHEHFDLLTDPST LNQILYVGVWSNQLSRHCFPQTTVSN*FSSLTNL CEFVKEFDAFLDA*LPN*RTNVYVNNLQ*YFFD FP*NC*KWKFKSVPSQSISAFRWCHSHTSVIIF LINHFIQVSLNQYTLG*HLALEHTFPS*RQSTGV CFLYTVKDFRMLALGFQQSLKRYGLDQIS*FYV FSGILT*NISVLK*IKKILAIKLKCSLLFFTFT SITTMILSVPYYLMQLNYPGMTNLQNERILYFRI LGFQQ*DFTGQVWSLTPVIPAIWEVWEVKAVDR LSPGVQDQPGQHGKTPSLPKIQTSASCGGACL* SQLPWGLMRENHLIPERLQ*AKITPLHSSLGDKT RPCL

Frame 2

GK*CAFLS**TLAVIF*KFRK*FKI*ISHFTGL RKCNKSLGIPIFIIGMLILCEDKWKYFIFFSP* TRGRVFIILQ**R*G**ETD**ATRQSCMCRLH *FG*KESTVVSCIGGLS*L***DCCKKGQYSCSI FQRWKIYFSSKKRCP*NY**HCTKA*CCFKASL *TGT*ISQK*NYSC*LED*IERR*L*Q*SRGRR GGGR**KRKGG**Q*RRRRNRTISRRKGELSSAI VQIYGR*RYTY*QTTCTWISKFESL*VIQTCTQ TWRI**Y*KWSCLETSLPRSWNPCLKFSCRIQC *MCL*KILIWF*GVL*ISQH*ISDGIARESC*QA M*GV*KCKRNKS*GGK*NRDQRNKDGGGEEYNT KRRKAY*G*N*KKRKY*ALSGK*KEFIRIYTYT F*SGKRS*H*KTRRQ*KSG*QR**HN*GR*IPQH KGRS*GRKSKIWR*NE*RRR*R**RSRRGGGGG RRRRG*R***QQ*GRGV*VLSTRHESPSAVWTR EKSKNV*S*Y*RF*CRRWRGPLLGALLRMECEIR *MD*SR*NSKTC**KCAKDKTSEENKE*IRQRK RQR*KILSKKL*TSALVQTTISDKSIS*NGIQT GSH*CQKL*YCSY*VHRNYFDP*WTSSF*KFC*R Q*AGR*ERCSRHG**WQRGI*D*SFDQQQK*SY FKGGTEQFIFARRKQSSCRFGNIQTSVKISRKI KERYRSIIRRY*L*RR*SHKKEKGCQEGHNR*IF KTTNKTW*KKVLQYRRVSKNWITWQKGREGQEQ RITLHGKQ*QQLFR*R*RRNKSKDDTN*EIQWF GGKKKISTDNWFLFRIFRSGRKKD*TFK*L**KT SKQQGQRSKRCLVKYSGTVA*KNAERAFFRL*Y *GCSFPTASCPRGGGGRGVTADCG*RGELFTQC RTRKTTSSQCR**TH*RKNSRGQ*QKSRISK*WQ *FSAKYPSYYT*IAFISHCNRRQPAAVFCNSIR TTGSKPRRGSKYQE*N**HN*GG*CCWGAPRPP V*RE*LASRF*CQCELKQ**SARTRTS*KR*EGK CVC*LILGFPLLKFQ*FHSISCYNLRRLSVIFV *TW*KWKF*R*FENE*WNAFKSLRRL*CALLEP SMAFYCGPEHMLEIAPRPKSKPV*EFIICSG*LY GMSSLNLFL*HCFCNCNVQFLTNILIY*QTPPP LTKYCM*GFGATNCPGTAFLRQPCQTDFQA*LT CVSL*RNLMLS*MHSFQIEGPMCTLITYSNTFLI FREIVKSGNSNRYLPKVLVPFDGAIAILLSSFF L*TTSFRYL*ISIL*ADTWLWNTLFHRKDRALE YVFYIP*KILEC*L*VFSKA*RDMV*IKLVNSMF SQES*LKTFLF*NKLKKYLQLN*NVLCFFSHLQ V*LL*FYLCHTISCN*TIQA*LIFKMKESFISE Y*AFNSKILLARCGHSHL*SQQFGRSGRSRRWIA *VQEFKTSLDNMAKPHLYQKYKRQPAVVAHACS PSYLGG**GRIT*SRKGCSEPRSRHCTPAWVIK QDPV

Sequence ARID4B.bAug05

GGCGGGGCCAGATGTTGATCTCGCTCCCACTTGTCGGGTCTGAGCCCGGAACGGGACGTGGGCAGGGGCTCTGTGGCGGGCCGGTCCTGCCCGCGGCCCA CAGGCCCTCCTGGCCCCTCGGTGGCCCCCGGCCGGCCTCTCGCTCGGACGCGGCGCGTGGGGGCGCGGATTCGCTCGGCCGGGCGCCGAGGCCCTAGGGG AGAGCGGCCGGCCCTGCGCCGGACGCCGGGCTTGTTGTGAGTTTCTTCTCTGACAGAAATGGCGTCATTGTCGTAGACGGGAAACTCCGTCGGGTCTCGA CAATGGGGACGGGAAGCTGCCGAGCTGTGTGCAGCTGAACCTGGTGTTTTAGAGGATACCTTGGTCCCAGAGTCATCATGAAGGCCCTTGATGAGCCTCC CTATTTGACAGTGGGCACTGATGTGAGTGCTAAATACAGAGGAGCCTTTTGTGAAGCCAAGATCAAGACAGCAAAAAGACTTGTCAAAGTCAAGGTGACA TTTAGACATGATTCTTCAACAGTGGAAGTTCAGGATGACCACATAAAGGGCCCACTAAAGGTAGGAGCTATTGTGGAAGTGAAGAATCTTGATGGTGCAT ATCAGGAAGCTGTTATCAATAAACTAACAGATGCGAGTTGGTACACTGTAGTTTTTGATGACGGAGATGAGAAGACACTGAGACGATCTTCACTGTGCCT GAAAGGAGAGAGGCATTTTGCTGAAAGTGAAACATTAGACCAGCTCCCACTCACCAACCCTGAGCATTTTGGCACTCCAGTCATAGGAAAGAAAACAAAT AGAGGAAGAAGATCTAATCATATACCAGAGGAAGAGTCTTCATCATCCTCCAGTGATGAAGATGAGGATGATAGGAAACAGATTGATGAGCTACTAGGCA AAGTTGTATGTGTAGATTACATTAGTTTGGATAAAAAGAAAGCACTGTGGTTTCCTGCATTGGTGGTTTGTCCTGATTGTAGTGATGAGATTGCTGTAAA AAAGGACAATATTCTTGTTCGATCTTTCAAAGATGGAAAATTTACTTCAGTTCCAAGAAAAGATGTCCATGAAATTACTAGTGACACTGCACCAAAGCCT GATGCTGTTTTAAAGCAAGCCTTTGAACAGGCACTTGAATTTCACAAAAGTAGAACTATTCCTGCTAACTGGAAGACTGAATTGAAAGAAGATAGCTCTA GCAGTGAAGCAGAGGAAGAAGAGGAGGAGGAAGATGATGAAAAAGAAAAGGAGGATAATAGCAGTGAAGAAGAAGAAGAAATAGAACCATTTCCAGAAGA AAGGGAGAACTTTCTTCAGCAATTGTACAAATTTATGGAAGATAGAGGTACACCTATTAACAAACGACCTGTACTTGGATATCGAAATTTGAATCTCTTT AAGTTATTCAGACTTGTACACAAACTTGGAGGATTTGATAATATTGAAAGTGGAGCTGTTTGGAAACAAGTCTACCAAGATCTTGGAATCCCTGTCTTAA ATTCAGCTGCAGGATACAATGTTAAATGTGCTTATAAAAAATACTTATATGGTTTTGAGGAGTACTGTAGATCAGCCAACATTGAATTTCAGATGGCATT GCCAGAGAAAGTTGTTAACAAGCAATGTAAGGAGTGTGAAAATGTAAAAGAAATAAAAGTTAAGGAGGAAAATGAAACAGAGATCAAAGAAATAAAGATG GAGGAGGAGAGGAATATAATACCAAGAGAAGAAAAGCCTATTGAGGATGAAATTGAAAGAAAAGAAAATATTAAGCCCTCTCTGGGAAGTAAAAAGAATT TATTAGAATCTATACCTACACATTCTGATCAGGAAAAAGAAGTTAACATTAAAAAACCAGAAGACAATGAAAATCTGGATGACAAAGATGATGACACAAC TAGGGTAGATGAATCCCTCAACATAAAGGTAGAAGCTGAGGAAGAAAAAGCAAAATCTGGAGATGAAACGAATAAAGAAGAAGATGAAGATGATGAAGAA GCAGAAGAGGAGGAGGAGGAGGAAGAAGAAGAAGAGGATGAAGATGATGATGACAACAATGAGGAAGAGGAGTTTGAGTGCTATCCACCAGGCATGAAAG TCCAAGTGCGGTATGGACGAGGGAAAAATCAAAAAATGTATGAAGCTAGTATTAAAGATTCTGATGTCGAAGGTGGAGAGGTCCTTTACTTGGTGCATTA CTGCGGATGGAATGTGAGATACGATGAATGGATTAAAGCAGATAAAATAGTAAGACCTGCTGATAAAAATGTGCCAAAGATAAAACATCGGAAGAAAATA AAGAATAAATTAGACAAAGAAAAAGACAAAGATGAAAAATACTCTCCAAAAAACTGTAAACTTCGGCGCTTGTCCAAACCACCATTTCAGACAAATCCAT CTCCTGAAATGGTATCCAAACTGGATCTCACTGATGCCAAAAACTCTGATACTGCTCATATTAAGTCCATAGAAATTACTTCGATCCTTAATGGACTTCA AGCTTCTGAAAGTTCTGCTGAAGACAGTGAGCAGGAAGATGAGAGAGGTGCTCAAGACATGGATAATAATGGCAAAGAGGAATCTAAGATTGATCATTTG ACCAACAACAGAAATGATCTTATTTCAAAGGAGGAACAGAACAGTTCATCTTTGCTAGAAGAAAACAAAGTTCATGCAGATTTGGTAATATCCAAACCAG TGTCAAAATCTCCAGAAAGATTAAGGAAAGATATAGAAGTATTATCCGAAGATACTGATTATGAAGAAGATGAAGTCACAAAAAAGAGAAAGGATGTCAA GAAGGACACAACAGATAAATCTTCAAAACCACAAATAAAACGTGGTAAAAGAAGGTATTGCAATACAGAAGAGTGTCTAAAAACTGGATCACCTGGCAAA AAGGAAGAGAAGGCCAAGAACAAAGAATCACTTTGCATGGAAAACAGTAGCAACAGCTCTTCAGATGAAGATGAAGAAGAAACAAAAGCAAAGATGACAC CAACTAAGAAATACAATGGTTTGGAGGAAAAAAGAAAATCTCTACGGACAACTGGTTTCTATTCAGGATTTTCAGAAGTGGCAGAAAAAAGGATTAAACT TTTAAATAACTCTGATGAAAGACTTCAAAACAGCAGGGCCAAAGATCGAAAAGATGTCTGGTCAAGTATTCAGGGACAGTGGCCTAAAAAAACGCTGAAA GAGCTTTTTTCAGACTCTGATACTGAGGCTGCAGCTTCCCCACCGCATCCTGCCCCAGAGGAGGGGGTGGCAGAGGAGTCACTGCAGACTGTGGCTGAAG AGGAGAGTTGTTCACCCAGTGTAGAACTAGAAAAACCACCTCCAGTCAATGTCGATAGTAAACCCATTGAAGAAAAAACAGTAGAGGTCAATGACAGAAA AGCAGAATTTCCAAGTAGTGGCAGTAATTCAGTGCTAAATACCCCTCCTACTACACCTGAATCGCCTTCATCAGTCACTGTAACAGAAGGCAGCCGGCAG CAGTCTTCTGTAACAGTATCAGAACCACTGGCTCCAAACCAAGAAGAGGTTCGAAGTATCAAGAGTGAAACTGATAGCACAATTGAGGTGGATAGTGTTG CTGGGGAGCTCCAAGACCTCCAGTCTGAAGGGAATAGCTCGCCAGCAGGTTTTGATGCCAGTGTGAGCTCAAGCAGTAGTAATCAGCCAGAACCAGAACA TCCTGAAAAAGCCTGTACAGGTCAGAAAAGAGTGAAAGATGCTCAGGGAGGAGGAAGTTCATCAAAAAAGCAGAAAAGAAGCCATAAAGCAACAGTGGTA AACAACAAAAAGAAGGGAAAAGGCACAAATAGTAGTGATAGTGAAGAACTTTCAGCTGGTGAAAGTATAACTAAGAGTCAGCCAGTCAAATCAGTTTCCA CTGGAATGAAGTCTCATAGTACCAAATCTCCCGCAAGGACGCAGTCTCCAGGAAAATGTGGAAAGAATGGTGATAAGGATCCTGATCTCAAGGAACCCAG TAATCGATTACCCAAAGTTTACAAATGGAGTTTTCAGATGTCGGACCTGGAAAATATGACAAGTGCCGAACGCATCACAATTCTTCAAGAAAAACTTCAA GAAATCAGAAAACATTATCTGTCATTAAAATCTGAAGTAGCTTCCATTGATCGGAGGAGAAAGCGTTTAAAGAAGAAAGAGAGAGAAAGTGCTGCTACAT CCTCATCCTCCTCTTCACCTTCATCCAGTTCCATAACAGCTGCTGTTATGTTAACTTTAGCTGAACCGTCAATGTCCAGCGCATCACAAAATGGAATGTC AGTTGAGTGCAGGTGACAGCAGGACTTGCTAAAGCACTTTGCACTTAATGGCTGTTGAGGGCCACTTTTTTTTTATACTGCACAGTGGCACAAAAAAATA TCAGACAAGCACTATTTTATATTTAAAAATTGTTTCTTGACAAGCTGACTTGGCACTTAAGTGCACTTTTTTATGAAGAAAAAGTACAATGAACTGCTTT TCCTCAAGCAATAATTGTTTCCAACTTGTCTGGGAATTGTGTGTCTGGTAACTGGAAGGCCTTCCACTGTGGCAAATGGAGGCTTTTCACTGCCTGTAGA GACAATACAGTAAGCATAGTTAAGGGGTGGGTCAGAACATGTTAAGATAACTTACTGTATATGTATTCCCTTGTATTTTGTTAAAGCTGGAACATTTGAT ATTTTTCCATTTATTTATGAAAAAATATGAACCTATTTTCATTTGTACAAGGTAATTGTTTTTTAAAGCAAGTCACCTTAGGGTGGCTTTAATTGTATAA GTCAAGCACATGTAATAAATTCAAAACCTGCAGTTAACAGGATATTAGACATCAATCCTGGTAACCAAATATTAAAGATTCTCTTTAAAAAAGACTGAAC ATGTTTACAGGTTTGAATTAGGCTAAAAGGTCTTGCAGTGGCTTTTCATGGCCCTTCAAATTGGAATGGAACTACTGTACTTTGCCATTTTTCTATAAAT CAGTATTTTTTTTTAATTTTGATATACATTGTGTGAAAAAAGAAAATGGCTAATAAACTGTATTAAATCTTAAACAATGTATAAAGATTGTACTTAGCCA GTTCAAAGTGTATATTTATTCATAATGAATTATAACAGTTATATTTTTGTGTTTTCTTGTAAATGTTTCTTTTCCCTTAAATACAGATAATTCATTTGTA TTGCTTATTTTATTATGAGCTACAACAAAAGGACTTCAGGAACAAGTAATGTATTAGTATGGTTCAAGATTGTTGATAGGAACTGTCTCAAAAGGATGGT GGTTATTTTAAATATAAATAGCTAATGGGGGTGGTAGGCCTATAAAATTAAATGCCTTGTATAAAATCCAAAATGAATGCAAAATTGTTTTCACTTGTAT TGACTTTATGTTGTATGATTCCAATCTCTGTTCTGTTTGGCACTTGTATTTAATTCTTCACCTTTGTAAGACATTTGTATATTGTGGATGTGTTCATTCA AGCTATTTAATATCTGGCACTGTTAATACACAGTACTTTATTGTACAGACTGTTTTACTGTTTTAATTGTAGTTCTGTGTACTTTTTTTGGATGGGGCTG GCATGTTTTCTTTGTTTCCTGGCAATACGACGTGGGAATTTCAATGCGTTTTGTTGTAGATGCTAACGTGTCAGAATCCTTTACATTCAACTTTTCTAAG AAAAGCATTTTCAGTCTTGTAGTGTGTGCTTACAGTAACTAATTTTGTTGAAAATGGTTTCAAGTTATTCAAATTTGTACAGGACTGTAAAGATTTGTTG ACAGCAAAATGTTGAAGAAAAAAGCTTATAGAATAAAAGCTATAAAGTATATATTAGGATCTGCAAACAATGAAGAATTATGTAATATATTGTACAAATG TAAGCAAAGGCTCTGAAATAAAATGCCATAGTTTGTGAATCCTTGATTTTTGTTTCTAAAAGATTTAGTAATTTTAGTTCATTTCTGTATGTG

RBP1L1-F1 (forward primer)
RBP1L1-R1 (reverse primer)
Single exon skipping

Frame 0

GGARC*SRSHLSGLSPERDVGRGSVAGRSCPRP TGPPGPSVAPGRPLARTRRVGARIRSAGRRGPRG ERPALRRTPGLL*VSSLTEMASLS*TGNSVGSR QWGREAAELCAAEPGVLEDTLVPESS*RPLMSL PI*QWALM*VLNTEEPFVKPRSRQQKDLSKSR*H LDMILQQWKFRMTT*RAH*R*ELLWK*RILMVH IRKLLSIN*QMRVGTL*FLMTEMRRH*DDLHCA *KERGILLKVKH*TSSHSPTLSILALQS*ERKQI EEEDLIIYQRKSLHHPPVMKMRMIGNRLMSY*A KLYV*ITLVWIKRKHCGFLHWWFVLIVVMRLL* KRTIFLFDLSKMENLLQFQEKMSMKLLVTLHQSL MLF*SKPLNRHLNFTKVELFLLTGRLN*KKIAL AVKQRKKRRRKMMKKKRRIIAVKKKKK*NHFQK KGRTFFSNCTNLWKIEVHLLTNDLYLDIEI*ISL SYSDLYTNLEDLIILKVELFGNKSTKILESLS* IQLQDTMLNVLIKNTYMVLRSTVDQPTLNFRWH CQRKLLTSNVRSVKM*KK*KLRRKMKQRSKK*RW RRRGI*YQEKKSLLRMKLKEKKILSPLWEVKRI Y*NLYLHILIRKKKLTLKNQKTMKIWMTKMMTQ LG*MNPST*R*KLRKKKQNLEMKRIKKKMKMMKK QKRRRRRKKKKRMKMMMTTMRKRSLSAIHQA*K SKCGMDEGKIKKCMKLVLKILMSKVERSFTWCI TADGM*DTMNGLKQIK**DLLIKMCQR*NIGRK* RIN*TKKKTKMKNTLQKTVNFGACPNHHFRQIH LLKWYPNWISLMPKTLILLILSP*KLLRSLMDF KLLKVLLKTVSRKMREVLKTWIIMAKRNLRLII* PTTEMILFQRRNRTVHLC*KKTKFMQIW*YPNQ CQNLQKD*GKI*KYYPKILIMKKMKSQKRERMS RRTQQINLQNHK*NVVKEGIAIQKSV*KLDHLAK RKRRPRTKNHFAWKTVATALQMKMKKKQKQR*H QLRNTMVWRKKENLYGQLVSIQDFQKWQKKGLN F*ITLMKDFKTAGPKIEKMSGQVFRDSGLKKR*K SFFQTLILRLQLPHRILPQRRGWQRSHCRLWLK RRVVHPV*N*KNHLQSMSIVNPLKKKQ*RSMTE KQNFQVVAVIQC*IPLLLHLNRLHQSL*QKAAGS SLL*QYQNHWLQTKKRFEVSRVKLIAQLRWIVL LGSSKTSSLKGIARQQVLMPV*AQAVVISQNQN ILKKPVQVRKE*KMLREEEVHQKSRKEAIKQQW* TTKRREKAQIVVIVKNFQLVKV*LRVSQSNQFP LE*SLIVPNLPQGRSLQENVERMVIRILISRNP VIDYPKFTNGVFRCRTWKI*QVPNASQFFKKNFK KSENIICH*NLK*LPLIGGESV*RRKREKVLLH PHPPLHLHPVP*QLLLC*L*LNRQCPAHHKMEC QLSAGDSRTC*STLHLMAVEGHFFFILHSGTKKY QTSTILYLKIVS*QADLALKCTFL*RKSTMNCF SSSNNCFQLVWELCVW*LEGLPLWQMEAFHCL* RQYSKHS*GVGQNMLR*LTVYVFPCILLKLEHLI FFHLFMKKYEPIFICTR*LFFKASHLRVALIV* VKHM**IQNLQLTGY*TSILVTKY*RFSLKKTE HVYRFELG*KVLQWLFMALQIGMELLYFAIFL*I SIFF*F*YTLCEKRKWLINCIKS*TMYKDCT*P VQSVYLFIMNYNSYIFVFSCKCFFSLKYR*FIC IAYFIMSYNKRTSGTSNVLVWFKIVDRNCLKRMV VILNINS*WGW*AYKIKCLV*NPK*MQNCFHLY *LYVV*FQSLFCLALVFNSSPL*DICILWMCSF KLFNIWHC*YTVLYCTDCFTVLIVVLCTFFGWGW HVFFVSWQYDVGISMRFVVDANVSESFTFNFSK KSIFSLVVCAYSN*FC*KWFQVIQICTGL*RFV DSKMLKKKAYRIKAIKYILGSANNEELCNILYKC KQRL*NKMP*FVNP*FLFLKDLVILVHFCM

Frame 1

AGPDVDLAPTCRV*ARNGTWAGALWRAGPARGP QALLAPRWPPAGLSLGRGAWGRGFARPGAEALG ESGRPCAGRRACCEFLL*QKWRHCRRRETPSGLD NGDGKLPSCVQLNLVF*RIPWSQSHHEGP**AS LFDSGH*CEC*IQRSLL*SQDQDSKKTCQSQGD I*T*FFNSGSSG*PHKGPTKGRSYCGSEES*WCI SGSCYQ*TNRCELVHCSF**RR*EDTETIFTVP ERREAFC*K*NIRPAPTHQP*AFWHSSHRKENK *RKKI*SYTRGRVFIILQ**R*G**ETD**ATRQ SCMCRLH*FG*KESTVVSCIGGLS*L***DCCK KGQYSCSIFQRWKIYFSSKKRCP*NY**HCTKA *CCFKASL*TGT*ISQK*NYSC*LED*IERR*L* Q*SRGRRGGGR**KRKGG**Q*RRRRNRTISRR KGELSSAIVQIYGR*RYTY*QTTCTWISKFESL *VIQTCTQTWRI**Y*KWSCLETSLPRSWNPCLK FSCRIQC*MCL*KILIWF*GVL*ISQH*ISDGI ARESC*QAM*GV*KCKRNKS*GGK*NRDQRNKD GGGEEYNTKRRKAY*G*N*KKRKY*ALSGK*KEF IRIYTYTF*SGKRS*H*KTRRQ*KSG*QR**HN *GR*IPQHKGRS*GRKSKIWR*NE*RRR*R**R SRRGGGGGRRRRG*R***QQ*GRGV*VLSTRHES PSAVWTREKSKNV*S*Y*RF*CRRWRGPLLGAL LRMECEIR*MD*SR*NSKTC**KCAKDKTSEEN KE*IRQRKRQR*KILSKKL*TSALVQTTISDKSI S*NGIQTGSH*CQKL*YCSY*VHRNYFDP*WTS SF*KFC*RQ*AGR*ERCSRHG**WQRGI*D*SF DQQQK*SYFKGGTEQFIFARRKQSSCRFGNIQTS VKISRKIKERYRSIIRRY*L*RR*SHKKEKGCQ EGHNR*IFKTTNKTW*KKVLQYRRVSKNWITWQ KGREGQEQRITLHGKQ*QQLFR*R*RRNKSKDDT N*EIQWFGGKKKISTDNWFLFRIFRSGRKKD*T FK*L**KTSKQQGQRSKRCLVKYSGTVA*KNAE RAFFRL*Y*GCSFPTASCPRGGGGRGVTADCG*R GELFTQCRTRKTTSSQCR**TH*RKNSRGQ*QK SRISK*WQ*FSAKYPSYYT*IAFISHCNRRQPA AVFCNSIRTTGSKPRRGSKYQE*N**HN*GG*CC WGAPRPPV*RE*LASRF*CQCELKQ**SARTRT S*KSLYRSEKSERCSGRRKFIKKAEKKP*SNSG KQQKEGKRHK*****RTFSW*KYN*ESASQISFH WNEVS*YQISRKDAVSRKMWKEW**GS*SQGTQ *SITQSLQMEFSDVGPGKYDKCRTHHNSSRKTS RNQKTLSVIKI*SSFH*SEEKAFKEERERKCCYI LILLFTFIQFHNSCCYVNFS*TVNVQRITKWNV S*VQVTAGLAKALCT*WLLRATFFLYCTVAQKN IRQALFYI*KLFLDKLTWHLSALFYEEKVQ*TAF PQAIIVSNLSGNCVSGNWKAFHCGKWRLFTACR DNTVSIVKGWVRTC*DNLLYMYSLVFC*SWNI* YFSIYL*KNMNLFSFVQGNCFLKQVTLGWL*LYK SSTCNKFKTCS*QDIRHQSW*PNIKDSL*KRLN MFTGLN*AKRSCSGFSWPFKLEWNYCTLPFFYK SVFFFNFDIHCVKKENG**TVLNLKQCIKIVLSQ FKVYIYS**IITVIFLCFLVNVSFPLNTDNSFV LLILL*ATTKGLQEQVMY*YGSRLLIGTVSKGW WLF*I*IANGGGRPIKLNALYKIQNECKIVFTCI DFMLYDSNLCSVWHLYLILHLCKTFVYCGCVHS SYLISGTVNTQYFIVQTVLLF*L*FCVLFLDGA GMFSLFPGNTTWEFQCVLL*MLTCQNPLHSTFLR KAFSVL*CVLTVTNFVENGFKLFKFVQDCKDLL TAKC*RKKLIE*KL*SIY*DLQTMKNYVIYCTN VSKGSEIKCHSL*ILDFCF*KI**F*FISVC

Frame 2

RGQMLISLPLVGSEPGTGRGQGLCGGPVLPAAH RPSWPLGGPRPASRSDAARGGADSLGRAPRP*G RAAGPAPDAGLVVSFFSDRNGVIVVDGKLRRVS TMGTGSCRAVCS*TWCFRGYLGPRVIMKALDEPP YLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVT FRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGA YQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCL KGERHFAESETLDQLPLTNPEHFGTPVIGKKTN RGRRSNHIPEEESSSSSSDEDEDDRKQIDELLG KVVCVDYISLDKKKALWFPALVVCPDCSDEIAVK KDNILVRSFKDGKFTSVPRKDVHEITSDTAPKP DAVLKQAFEQALEFHKSRTIPANWKTELKEDSS SSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEE RENFLQQLYKFMEDRGTPINKRPVLGYRNLNLF KLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVL NSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMAL PEKVVNKQCKECENVKEIKVKEENETEIKEIKM EEERNIIPREEKPIEDEIERKENIKPSLGSKKN LLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTT RVDESLNIKVEAEEEKAKSGDETNKEEDEDDEE AEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMK VQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHY CGWNVRYDEWIKADKIVRPADKNVPKIKHRKKI KNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNP SPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQ ASESSAEDSEQEDERGAQDMDNNGKEESKIDHL TNNRNDLISKEEQNSSSLLEENKVHADLVISKP VSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVK KDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGK KEEKAKNKESLCMENSSNSSSDEDEEETKAKMT PTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKL LNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLK ELFSDSDTEAAASPPHPAPEEGVAEESLQTVAE EESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRK AEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQ QSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSV AGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEH PEKACTGQKRVKDAQGGGSSSKKQKRSHKATVV NNKKKGKGTNSSDSEELSAGESITKSQPVKSVS TGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPS NRLPKVYKWSFQMSDLENMTSAERITILQEKLQ EIRKHYLSLKSEVASIDRRRKRLKKKERESAAT SSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMS VECR*QQDLLKHFALNGC*GPLFFYTAQWHKKI SDKHYFIFKNCFLTS*LGT*VHFFMKKKYNELL FLKQ*LFPTCLGIVCLVTGRPSTVANGGFSLPVE TIQ*A*LRGGSEHVKITYCICIPLYFVKAGTFD IFPFIYEKI*TYFHLYKVIVF*SKSP*GGFNCI SQAHVINSKPAVNRILDINPGNQILKILFKKD*T CLQV*IRLKGLAVAFHGPSNWNGTTVLCHFSIN QYFFLILIYIV*KKKMANKLY*ILNNV*RLYLA SSKCIFIHNEL*QLYFCVFL*MFLFP*IQIIHLY CLFYYELQQKDFRNK*CISMVQDC**ELSQKDG GYFKYK*LMGVVGL*N*MPCIKSKMNAKLFSLV LTLCCMIPISVLFGTCI*FFTFVRHLYIVDVFIQ AI*YLALLIHSTLLYRLFYCFNCSSVYFFWMGL ACFLCFLAIRRGNFNAFCCRC*RVRILYIQLF* EKHFQSCSVCLQ*LILLKMVSSYSNLYRTVKIC* QQNVEEKSL*NKSYKVYIRICKQ*RIM*YIVQM *AKALK*NAIVCESLIFVSKRFSNFSSFLYV

Sequence ARID4B.aAug05

AAAGGGGGGGAACCTAGAGTCGGTGGGGGGGAAGCGATGTTTGCCCGTCAGTCGAGTCCGGAGTGAGGAGCTCGGTCGCCGAAGCGGAGGGAGACTCTTG AGCTTCATCTTGCCGCCGCCACGGCCACCGCCTGGACCTTTGCCCGGAGGGAGCTGCAGAGGGTCCATCGCCGCCGTCCTCTGGAGGGCAGCGCGATTGG GGGCCCGGACCTCCAGTCCGGGGGGGATTTTTCGTCGTCCCCCTCCCCCCAACCAGGGAGCCCGAGCGGCCGCCAAACAAAGGTACCAGTCGCCGCCGCG GGAGGAGGAGGAGCCGGAGCCTCTGCCTCAGCAGCCGCTGGACCCGCCGCCCTTCTTCCCCATCTCTCCCCCGGGCCTGCTGGTTTTGGGGGGGAGAAGG AGAGAGGGGACTCTGGACGTGCCAGGGTCAGATCTCGCCTCCGAGGAAGGTGCAGCTGAACCTGGTGTTTTAGAGGATACCTTGGTCCCAGAGTCATCAT GAAGGCCCTTGATGAGCCTCCCTATTTGACAGTGGGCACTGATGTGAGTGCTAAATACAGAGGAGCCTTTTGTGAAGCCAAGATCAAGACAGCAAAAAGA CTTGTCAAAGTCAAGGTGACATTTAGACATGATTCTTCAACAGTGGAAGTTCAGGATGACCACATAAAGGGCCCACTAAAGGTAGGAGCTATTGTGGAAG TGAAGAATCTTGATGGTGCATATCAGGAAGCTGTTATCAATAAACTAACAGATGCGAGTTGGTACACTGTAGTTTTTGATGACGGAGATGAGAAGACACT GAGACGATCTTCACTGTGCCTGAAAGGAGAGAGGCATTTTGCTGAAAGTGAAACATTAGACCAGCTCCCACTCACCAACCCTGAGCATTTTGGCACTCCA GTCATAGGAAAGAAAACAAATAGAGGAAGAAGATCTAATCATATACCAGAGGAAGAGTCTTCATCATCCTCCAGTGATGAAGATGAGGATGATAGGAAAC AGATTGATGAGCTACTAGGCAAAGTTGTATGTGTAGATTACATTAGTTTGGATAAAAAGAAAGCACTGTGGTTTCCTGCATTGGTGGTTTGTCCTGATTG TAGTGATGAGATTGCTGTAAAAAAGGACAATATTCTTGTTCGATCTTTCAAAGATGGAAAATTTACTTCAGTTCCAAGAAAAGATGTCCATGAAATTACT AGTGACACTGCACCAAAGCCTGATGCTGTTTTAAAGCAAGCCTTTGAACAGGCACTTGAATTTCACAAAAGTAGAACTATTCCTGCTAACTGGAAGACTG AATTGAAAGAAGATAGCTCTAGCAGTGAAGCAGAGGAAGAAGAGGAGGAGGAAGATGATGAAAAAGAAAAGGAGGATAATAGCAGTGAAGAAGAAGAAGA AATAGAACCATTTCCAGAAGAAAGGGAGAACTTTCTTCAGCAATTGTACAAATTTATGGAAGATAGAGGTACACCTATTAACAAACGACCTGTACTTGGA TATCGAAATTTGAATCTCTTTAAGTTATTCAGACTTGTACACAAACTTGGAGGATTTGATAATATTGAAAGTGGAGCTGTTTGGAAACAAGTCTACCAAG ATCTTGGAATCCCTGTCTTAAATTCAGCTGCAGGATACAATGTTAAATGTGCTTATAAAAAATACTTATATGGTTTTGAGGAGTACTGTAGATCAGCCAA CATTGAATTTCAGATGGCATTGCCAGAGAAAGTTGTTAACAAGCAATGTAAGGAGTGTGAAAATGTAAAAGAAATAAAAGTTAAGGAGGAAAATGAAACA GAGATCAAAGAAATAAAGATGGAGGAGGAGAGGAATATAATACCAAGAGAAGAAAAGCCTATTGAGGATGAAATTGAAAGAAAAGAAAATATTAAGCCCT CTCTGGGAAGTAAAAAGAATTTATTAGAATCTATACCTACACATTCTGATCAGGAAAAAGAAGTTAACATTAAAAAACCAGAAGACAATGAAAATCTGGA TGACAAAGATGATGACACAACTAGGGTAGATGAATCCCTCAACATAAAGGTAGAAGCTGAGGAAGAAAAAGCAAAATCTGGAGATGAAACGAATAAAGAA GAAGATGAAGATGATGAAGAAGCAGAAGAGGAGGAGGAGGAGGAAGAAGAAGAAGAGGATGAAGATGATGATGACAACAATGAGGAAGAGGAGTTTGAGT GCTATCCACCAGGCATGAAAGTCCAAGTGCGGTATGGACGAGGGAAAAATCAAAAAATGTATGAAGCTAGTATTAAAGATTCTGATGTCGAAGGTGGAGA GGTCCTTTACTTGGTGCATTACTGCGGATGGAATGTGAGATACGATGAATGGATTAAAGCAGATAAAATAGTAAGACCTGCTGATAAAAATGTGCCAAAG ATAAAACATCGGAAGAAAATAAAGAATAAATTAGACAAAGAAAAAGACAAAGATGAAAAATACTCTCCAAAAAACTGTAAACTTCGGCGCTTGTCCAAAC CACCATTTCAGACAAATCCATCTCCTGAAATGGTATCCAAACTGGATCTCACTGATGCCAAAAACTCTGATACTGCTCATATTAAGTCCATAGAAATTAC TTCGATCCTTAATGGACTTCAAGCTTCTGAAAGTTCTGCTGAAGACAGTGAGCAGGAAGATGAGAGAGGTGCTCAAGACATGGATAATAATGGCAAAGAG GAATCTAAGATTGATCATTTGACCAACAACAGAAATGATCTTATTTCAAAGGAGGAACAGAACAGTTCATCTTTGCTAGAAGAAAACAAAGTTCATGCAG ATTTGGTAATATCCAAACCAGTGTCAAAATCTCCAGAAAGATTAAGGAAAGATATAGAAGTATTATCCGAAGATACTGATTATGAAGAAGATGAAGTCAC AAAAAAGAGAAAGGATGTCAAGAAGGACACAACAGATAAATCTTCAAAACCACAAATAAAACGTGGTAAAAGAAGGTATTGCAATACAGAAGAGTGTCTA AAAACTGGATCACCTGGCAAAAAGGAAGAGAAGGCCAAGAACAAAGAATCACTTTGCATGGAAAACAGTAGCAACAGCTCTTCAGATGAAGATGAAGAAG AAACAAAAGCAAAGATGACACCAACTAAGAAATACAATGGTTTGGAGGAAAAAAGAAAATCTCTACGGACAACTGGTTTCTATTCAGGATTTTCAGAAGT GGCAGAAAAAAGGATTAAACTTTTAAATAACTCTGATGAAAGACTTCAAAACAGCAGGGCCAAAGATCGAAAAGATGTCTGGTCAAGTATTCAGGGACAG TGGCCTAAAAAAACGCTGAAAGAGCTTTTTTCAGACTCTGATACTGAGGCTGCAGCTTCCCCACCGCATCCTGCCCCAGAGGAGGGGGTGGCAGAGGAGT CACTGCAGACTGTGGCTGAAGAGGAGAGTTGTTCACCCAGTGTAGAACTAGAAAAACCACCTCCAGTCAATGTCGATAGTAAACCCATTGAAGAAAAAAC AGTAGAGGTCAATGACAGAAAAGCAGAATTTCCAAGTAGTGGCAGTAATTCAGTGCTAAATACCCCTCCTACTACACCTGAATCGCCTTCATCAGTCACT GTAACAGAAGGCAGCCGGCAGCAGTCTTCTGTAACAGTATCAGAACCACTGGCTCCAAACCAAGAAGAGGTTCGAAGTATCAAGAGTGAAACTGATAGCA CAATTGAGGTGGATAGTGTTGCTGGGGAGCTCCAAGACCTCCAGTCTGAAGGGAATAGCTCGCCAGCAGGTTTTGATGCCAGTGTGAGCTCAAGCAGTAG TAATCAGCCAGAACCAGAACATCCTGAAAAAGCCTGTACAGGTCAGAAAAGAGTGAAAGATGCTCAGGGAGGAGGAAGTTCATCAAAAAAGCAGAAAAGA AGCCATAAAGCAACAGTGGTAAACAACAAAAAGAAGGGAAAAGGCACAAATAGTAGTGATAGTGAAGAACTTTCAGCTGGTGAAAGTATAACTAAGAGTC AGCCAGTCAAATCAGTTTCCACTGGAATGAAGTCTCATAGTACCAAATCTCCCGCAAGGACGCAGTCTCCAGGAAAATGTGGAAAGAATGGTGATAAGGA TCCTGATCTCAAGGAACCCAGTAATCGATTACCCAAAGTTTACAAATGGAGTTTTCAGATGTCGGACCTGGAAAATATGACAAGTGCCGAACGCATCACA ATTCTTCAAGAAAAACTTCAAGAAATCAGAAAACATTATCTGTCATTAAAATCTGAAGTAGCTTCCATTGATCGGAGGAGAAAGCGTTTAAAGAAGAAAG AGAGAGAAAGTGCTGCTACATCCTCATCCTCCTCTTCACCTTCATCCAGTTCCATAACAGCTGCTGTTATGTTAACTTTAGCTGAACCGTCAATGTCCAG CGCATCACAAAATGGAATGTCAGTTGAGTGCAGGTGACAGCAGGACTTGCTAAAGCACTTTGCACTTAATGGCTGTTGAGGGCCACTTTTTTTTTATACT GCACAGTGGCACAAAAAAATATCAGACAAGCACTATTTTATATTTAAAAATTGTTTCTTGACAAGCTGACTTGGCACTTAAGTGCACTTTTTTATGAAGA AAAAGTACAATGAACTGCTTTTCCTCAAGCAATAATTGTTTCCAACTTGTCTGGGAATTGTGTGTCTGGTAACTGGAAGGCCTTCCACTGTGGCAAATGG AGGCTTTTCACTGCCTGTAGAGACAATACAGTAAGCATAGTTAAGGGGTGGGTCAGAACATGTTAAGATAACTTACTGTATATGTATTCCCTTGTATTTT GTTAAAGCTGGAACATTTGATATTTTTCCATTTATTTATGAAAAAATATGAACCTATTTTCATTTGTACAAGGTAATTGTTTTTTAAAGCAAGTCACCTT AGGGTGGCTTTAATTGTATAAGTCAAGCACATGTAATAAATTCAAAACCTGCAGTTAACAGGATATTAGACATCAATCCTGGTAACCAAATATTAAAGAT TCTCTTTAAAAAAGACTGAACATGTTTACAGGTTTGAATTAGGCTAAAAGGTCTTGCAGTGGCTTTTCATGGCCCTTCAAATTGGAATGGAACTACTGTA CTTTGCCATTTTTCTATAAATCAGTATTTTTTTTTAATTTTGATATACATTGTGTGAAAAAAGAAAATGGCTAATAAACTGTATTAAATCTTAAACAATG TATAAAGATTGTACTTAGCCAGTTCAAAGTGTATATTTATTCATAATGAATTATAACAGTTATATTTTTGTGTTTTCTTGTAAATGTTTCTTTTCCCTTA AATACAGATAATTCATTTGTATTGCTTATTTTATTATGAGCTACAACAAAAGGACTTCAGGAACAAGTAATGTATTAGTATGGTTCAAGATTGTTGATAG GAACTGTCTCAAAAGGATGGTGGTTATTTTAAATATAAATAGCTAATGGGGGTGGTAGGCCTATAAAATTAAATGCCTTGTATAAAATCCAAAATGAATG CAAAATTGTTTTCACTTGTATTGACTTTATGTTGTATGATTCCAATCTCTGTTCTGTTTGGCACTTGTATTTAATTCTTCACCTTTGTAAGACATTTGTA TATTGTGGATGTGTTCATTCAAGCTATTTAATATCTGGCACTGTTAATACACAGTACTTTATTGTACAGACTGTTTTACTGTTTTAATTGTAGTTCTGTG TACTTTTTTTGGATGGGGCTGGCATGTTTTCTTTGTTTCCTGGCAATACGACGTGGGAATTTCAATGCGTTTTGTTGTAGATGCTAACGTGTCAGAATCC TTTACATTCAACTTTTCTAAGAAAAGCATTTTCAGTCTTGTAGTGTGTGCTTACAGTAACTAATTTTGTTGAAAATGGTTTCAAGTTATTCAAATTTGTA CAGGACTGTAAAGATTTGTTGACAGCAAAATGTTGAAGAAAAAAGCTTATAGAATAAAAGCTATAAAGTATATATTAGGATCTGCAAACAATGAAGAATT ATGTAATATATTGTACAAATGTAAGCAAAGGCTCTGAAATAAAATGCCATAGTTTGTGAATCCTTGATTTTTGTTTCTAAAAGATTTAGTAATTTTAGTT CATTTCTGTATGTG

RBP1L1-F1 (forward primer)
RBP1L1-R1 (reverse primer)
Single exon skipping

Frame 0

KGGEPRVGGGEAMFARQSSPE*GARSPKRRETL ELHLAAATATAWTFARRELQRVHRRRPLEGSAIG GPDLQSGGDFSSSPSPQPGSPSGRQTKVPVAAA GGGGAGASASAAAGPAALLPHLSPGPAGFGGEK ERGDSGRARVRSRLRGRCS*TWCFRGYLGPRVIM KALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKR LVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVE VKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTL RRSSLCLKGERHFAESETLDQLPLTNPEHFGTP VIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRK QIDELLGKVVCVDYISLDKKKALWFPALVVCPDC SDEIAVKKDNILVRSFKDGKFTSVPRKDVHEIT SDTAPKPDAVLKQAFEQALEFHKSRTIPANWKT ELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEE IEPFPEERENFLQQLYKFMEDRGTPINKRPVLG YRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQ DLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSAN IEFQMALPEKVVNKQCKECENVKEIKVKEENET EIKEIKMEEERNIIPREEKPIEDEIERKENIKP SLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLD DKDDDTTRVDESLNIKVEAEEEKAKSGDETNKE EDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFE CYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGE VLYLVHYCGWNVRYDEWIKADKIVRPADKNVPK IKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSK PPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEIT SILNGLQASESSAEDSEQEDERGAQDMDNNGKE ESKIDHLTNNRNDLISKEEQNSSSLLEENKVHA DLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVT KKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECL KTGSPGKKEEKAKNKESLCMENSSNSSSDEDEE ETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEV AEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQ WPKKTLKELFSDSDTEAAASPPHPAPEEGVAEE SLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKT VEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVT VTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDS TIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSS NQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKR SHKATVVNNKKKGKGTNSSDSEELSAGESITKS QPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKD PDLKEPSNRLPKVYKWSFQMSDLENMTSAERIT ILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKK ERESAATSSSSSSPSSSSITAAVMLTLAEPSMSS ASQNGMSVECR*QQDLLKHFALNGC*GPLFFYT AQWHKKISDKHYFIFKNCFLTS*LGT*VHFFMK KKYNELLFLKQ*LFPTCLGIVCLVTGRPSTVANG GFSLPVETIQ*A*LRGGSEHVKITYCICIPLYF VKAGTFDIFPFIYEKI*TYFHLYKVIVF*SKSP *GGFNCISQAHVINSKPAVNRILDINPGNQILKI LFKKD*TCLQV*IRLKGLAVAFHGPSNWNGTTV LCHFSINQYFFLILIYIV*KKKMANKLY*ILNN V*RLYLASSKCIFIHNEL*QLYFCVFL*MFLFP* IQIIHLYCLFYYELQQKDFRNK*CISMVQDC** ELSQKDGGYFKYK*LMGVVGL*N*MPCIKSKMN AKLFSLVLTLCCMIPISVLFGTCI*FFTFVRHLY IVDVFIQAI*YLALLIHSTLLYRLFYCFNCSSV YFFWMGLACFLCFLAIRRGNFNAFCCRC*RVRI LYIQLF*EKHFQSCSVCLQ*LILLKMVSSYSNLY RTVKIC*QQNVEEKSL*NKSYKVYIRICKQ*RI M*YIVQM*AKALK*NAIVCESLIFVSKRFSNFS SFLYV

Frame 1

KGGNLESVGGKRCLPVSRVRSEELGRRSGGRLL SFILPPPRPPPGPLPGGSCRGSIAAVLWRAARL GARTSSPGGIFRRPPPPNQGARAAAKQRYQSPPR EEEEPEPLPQQPLDPPPFFPISPPGLLVLGGRR REGTLDVPGSDLASEEGAAEPGVLEDTLVPESS *RPLMSLPI*QWALM*VLNTEEPFVKPRSRQQKD LSKSR*HLDMILQQWKFRMTT*RAH*R*ELLWK *RILMVHIRKLLSIN*QMRVGTL*FLMTEMRRH *DDLHCA*KERGILLKVKH*TSSHSPTLSILALQ S*ERKQIEEEDLIIYQRKSLHHPPVMKMRMIGN RLMSY*AKLYV*ITLVWIKRKHCGFLHWWFVLI VVMRLL*KRTIFLFDLSKMENLLQFQEKMSMKLL VTLHQSLMLF*SKPLNRHLNFTKVELFLLTGRL N*KKIALAVKQRKKRRRKMMKKKRRIIAVKKKK K*NHFQKKGRTFFSNCTNLWKIEVHLLTNDLYLD IEI*ISLSYSDLYTNLEDLIILKVELFGNKSTK ILESLS*IQLQDTMLNVLIKNTYMVLRSTVDQP TLNFRWHCQRKLLTSNVRSVKM*KK*KLRRKMKQ RSKK*RWRRRGI*YQEKKSLLRMKLKEKKILSP LWEVKRIY*NLYLHILIRKKKLTLKNQKTMKIW MTKMMTQLG*MNPST*R*KLRKKKQNLEMKRIKK KMKMMKKQKRRRRRKKKKRMKMMMTTMRKRSLS AIHQA*KSKCGMDEGKIKKCMKLVLKILMSKVE RSFTWCITADGM*DTMNGLKQIK**DLLIKMCQR *NIGRK*RIN*TKKKTKMKNTLQKTVNFGACPN HHFRQIHLLKWYPNWISLMPKTLILLILSP*KL LRSLMDFKLLKVLLKTVSRKMREVLKTWIIMAKR NLRLII*PTTEMILFQRRNRTVHLC*KKTKFMQ IW*YPNQCQNLQKD*GKI*KYYPKILIMKKMKS QKRERMSRRTQQINLQNHK*NVVKEGIAIQKSV* KLDHLAKRKRRPRTKNHFAWKTVATALQMKMKK KQKQR*HQLRNTMVWRKKENLYGQLVSIQDFQK WQKKGLNF*ITLMKDFKTAGPKIEKMSGQVFRDS GLKKR*KSFFQTLILRLQLPHRILPQRRGWQRS HCRLWLKRRVVHPV*N*KNHLQSMSIVNPLKKK Q*RSMTEKQNFQVVAVIQC*IPLLLHLNRLHQSL *QKAAGSSLL*QYQNHWLQTKKRFEVSRVKLIA QLRWIVLLGSSKTSSLKGIARQQVLMPV*AQAV VISQNQNILKKPVQVRKE*KMLREEEVHQKSRKE AIKQQW*TTKRREKAQIVVIVKNFQLVKV*LRV SQSNQFPLE*SLIVPNLPQGRSLQENVERMVIR ILISRNPVIDYPKFTNGVFRCRTWKI*QVPNASQ FFKKNFKKSENIICH*NLK*LPLIGGESV*RRK REKVLLHPHPPLHLHPVP*QLLLC*L*LNRQCP AHHKMECQLSAGDSRTC*STLHLMAVEGHFFFIL HSGTKKYQTSTILYLKIVS*QADLALKCTFL*R KSTMNCFSSSNNCFQLVWELCVW*LEGLPLWQM EAFHCL*RQYSKHS*GVGQNMLR*LTVYVFPCIL LKLEHLIFFHLFMKKYEPIFICTR*LFFKASHL RVALIV*VKHM**IQNLQLTGY*TSILVTKY*R FSLKKTEHVYRFELG*KVLQWLFMALQIGMELLY FAIFL*ISIFF*F*YTLCEKRKWLINCIKS*TM YKDCT*PVQSVYLFIMNYNSYIFVFSCKCFFSL KYR*FICIAYFIMSYNKRTSGTSNVLVWFKIVDR NCLKRMVVILNINS*WGW*AYKIKCLV*NPK*M QNCFHLY*LYVV*FQSLFCLALVFNSSPL*DIC ILWMCSFKLFNIWHC*YTVLYCTDCFTVLIVVLC TFFGWGWHVFFVSWQYDVGISMRFVVDANVSES FTFNFSKKSIFSLVVCAYSN*FC*KWFQVIQIC TGL*RFVDSKMLKKKAYRIKAIKYILGSANNEEL CNILYKCKQRL*NKMP*FVNP*FLFLKDLVILV HFCM

Frame 2

RGGT*SRWGGSDVCPSVESGVRSSVAEAEGDS* ASSCRRHGHRLDLCPEGAAEGPSPPSSGGQRDW GPGPPVRGGFFVVPLPPTREPERPPNKGTSRRR GRRRSRSLCLSSRWTRRPSSPSLPRACWFWGGEG ERGLWTCQGQISPPRKVQLNLVF*RIPWSQSHH EGP**ASLFDSGH*CEC*IQRSLL*SQDQDSKK TCQSQGDI*T*FFNSGSSG*PHKGPTKGRSYCGS EES*WCISGSCYQ*TNRCELVHCSF**RR*EDT ETIFTVPERREAFC*K*NIRPAPTHQP*AFWHS SHRKENK*RKKI*SYTRGRVFIILQ**R*G**ET D**ATRQSCMCRLH*FG*KESTVVSCIGGLS*L ***DCCKKGQYSCSIFQRWKIYFSSKKRCP*NY **HCTKA*CCFKASL*TGT*ISQK*NYSC*LED* IERR*L*Q*SRGRRGGGR**KRKGG**Q*RRRR NRTISRRKGELSSAIVQIYGR*RYTY*QTTCTW ISKFESL*VIQTCTQTWRI**Y*KWSCLETSLPR SWNPCLKFSCRIQC*MCL*KILIWF*GVL*ISQ H*ISDGIARESC*QAM*GV*KCKRNKS*GGK*N RDQRNKDGGGEEYNTKRRKAY*G*N*KKRKY*AL SGK*KEFIRIYTYTF*SGKRS*H*KTRRQ*KSG *QR**HN*GR*IPQHKGRS*GRKSKIWR*NE*R RR*R**RSRRGGGGGRRRRG*R***QQ*GRGV*V LSTRHESPSAVWTREKSKNV*S*Y*RF*CRRWR GPLLGALLRMECEIR*MD*SR*NSKTC**KCAK DKTSEENKE*IRQRKRQR*KILSKKL*TSALVQT TISDKSIS*NGIQTGSH*CQKL*YCSY*VHRNY FDP*WTSSF*KFC*RQ*AGR*ERCSRHG**WQR GI*D*SFDQQQK*SYFKGGTEQFIFARRKQSSCR FGNIQTSVKISRKIKERYRSIIRRY*L*RR*SH KKEKGCQEGHNR*IFKTTNKTW*KKVLQYRRVS KNWITWQKGREGQEQRITLHGKQ*QQLFR*R*RR NKSKDDTN*EIQWFGGKKKISTDNWFLFRIFRS GRKKD*TFK*L**KTSKQQGQRSKRCLVKYSGT VA*KNAERAFFRL*Y*GCSFPTASCPRGGGGRGV TADCG*RGELFTQCRTRKTTSSQCR**TH*RKN SRGQ*QKSRISK*WQ*FSAKYPSYYT*IAFISH CNRRQPAAVFCNSIRTTGSKPRRGSKYQE*N**H N*GG*CCWGAPRPPV*RE*LASRF*CQCELKQ* *SARTRTS*KSLYRSEKSERCSGRRKFIKKAEK KP*SNSGKQQKEGKRHK*****RTFSW*KYN*ES ASQISFHWNEVS*YQISRKDAVSRKMWKEW**G S*SQGTQ*SITQSLQMEFSDVGPGKYDKCRTHH NSSRKTSRNQKTLSVIKI*SSFH*SEEKAFKEER ERKCCYILILLFTFIQFHNSCCYVNFS*TVNVQ RITKWNVS*VQVTAGLAKALCT*WLLRATFFLY CTVAQKNIRQALFYI*KLFLDKLTWHLSALFYEE KVQ*TAFPQAIIVSNLSGNCVSGNWKAFHCGKW RLFTACRDNTVSIVKGWVRTC*DNLLYMYSLVF C*SWNI*YFSIYL*KNMNLFSFVQGNCFLKQVTL GWL*LYKSSTCNKFKTCS*QDIRHQSW*PNIKD SL*KRLNMFTGLN*AKRSCSGFSWPFKLEWNYC TLPFFYKSVFFFNFDIHCVKKENG**TVLNLKQC IKIVLSQFKVYIYS**IITVIFLCFLVNVSFPL NTDNSFVLLILL*ATTKGLQEQVMY*YGSRLLI GTVSKGWWLF*I*IANGGGRPIKLNALYKIQNEC KIVFTCIDFMLYDSNLCSVWHLYLILHLCKTFV YCGCVHSSYLISGTVNTQYFIVQTVLLF*L*FC VLFLDGAGMFSLFPGNTTWEFQCVLL*MLTCQNP LHSTFLRKAFSVL*CVLTVTNFVENGFKLFKFV QDCKDLLTAKC*RKKLIE*KL*SIY*DLQTMKN YVIYCTNVSKGSEIKCHSL*ILDFCF*KI**F*F ISVC