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Sequences

Sequence FYN.cAug05

GGAGCTGAGAGAGGGGGAGACCAGCGCAGGTCTGAGGAGCTGAGAAGGGAGGCTTACGTGAAGGGAATTTAGATAATGGGCTGTGTGCAATGTAAGGATA AAGAAGCAACAAAACTGACGGAGGAGAGGGACGGCAGCCTGAACCAGAGCTCTGGGTACCGCTATGGCACAGACCCCACCCCTCAGCACTACCCCAGCTT CGGTGTGACCTCCATCCCCAACTACAACAACTTCCACGCAGCCGGGGGCCAAGGACTCACCGTCTTTGGAGGTGTGAACTCTTCGTCTCATACGGGGACC TTGCGTACGAGAGGAGGAACAGGAGTGACACTCTTTGTGGCCCTTTATGACTATGAAGCACGGACAGAAGATGACCTGAGTTTTCACAAAGGAGAAAAAT TTCAAATATTGAACAGCTCGGAAGGAGATTGGTGGGAAGCCCGCTCCTTGACAACTGGAGAGACAGGTTACATTCCCAGCAATTATGTGGCTCCAGTTGA CTCTATCCAGGCAGAAGAGTGGTACTTTGGAAAACTTGGCCGAAAAGATGCTGAGCGACAGCTATTGTCCTTTGGAAACCCAAGAGGTACCTTTCTTATC CGCGAGAGTGAAACCACCAAAGGTGCCTATTCACTTTCTATCCGTGATTGGGATGATATGAAAGGAGACCATGTCAAACATTATAAAATTCGCAAACTTG ACAATGGTGGATACTACATTACCACCCGGGCCCAGTTTGAAACACTTCAGCAGCTTGTACAACATTACTCAGGTACCTGGAATGGAAACACAAAAGTAGC CATAAAGACTCTTAAACCAGGCACAATGTCCCCCGAATCATTCCTTGAGGAAGCGCAGATCATGAAGAAGCTGAAGCACGACAAGCTGGTCCAGCTCTAT GCAGTGGTGTCTGAGGAGCCCATCTACATCGTCACCGAGTATATGAACAAAGGAAGTTTACTGGATTTCTTAAAAGATGGAGAAGGAAGAGCTCTGAAAT TACCAAATCTTGTGGACATGGCAGCACAGGTGGCTGCAGGAATGGCTTACATCGAGCGCATGAATTATATCCATAGAGATCTGCGATCAGCAAACATTCT AGTGGGGAATGGACTCATATGCAAGATTGCTGACTTCGGATTGGCCCGATTGATAGAAGACAATGAGTACACAGCAAGACAAGGTGCAAAGTTCCCCATC AAGTGGACGGCCCCCGAGGCAGCCCTGTACGGGAGGTTCACAATCAAGTCTGACGTGTGGTCTTTTGGAATCTTACTCACAGAGCTGGTCACCAAAGGAA GAGTGCCATACCCAGGCATGAACAACCGGGAGGTGCTGGAGCAGGTGGAGCGAGGCTACAGGATGCCCTGCCCGCAGGACTGCCCCATCTCTCTGCATGA GCTCATGATCCACTGCTGGAAAAAGGACCCTGAAGAACGCCCCACTTTTGAGTACTTGCAGAGCTTCCTGGAAGACTACTTTACCGCGACAGAGCCCCAG TACCAACCTGGTGAAAACCTGTAAGGCCCGGGTCTGCGGAGAGAGGCCTTGTCCCAGAGGCTGCCCCACCCCTCCCCATTAGCTTTCAATTCCGTAGCCA GCTGCTCCCCAGCAGCGGAACCGCCCAGGATCAGATTGCATGTGACTCTGAAGCTGACGAACTTCCATGGCCCTCATTAATGACACTTGTCCCCAAATCC GAACCTCCTCTGTGAAGCATTCGAGACAGAACCTTGTTATTTCTCAGACTTTGGAAAATGCATTGTATCGATGTTATGTAAAAGGCCAAACCTCTGTTCA GTGTAAATAGTTACTCCAGTGCCAACAATCCTAGTGCTTTCCTTTTTTAAAAATGCAAATCCTATGTGATTTTAACTCTGTCTTCACCTGATTCAACTAA AAAAAAAAAAGTATTATTTTCCAAAAGTGGCCTCTTTGTCTAAAACAATAAAATTTTTTTTCATGTTTTAACAAAAACCAATCAGGACAGGTGTTTGTTT TTGTTTTCTTTTTTATAAATATGAATATATATAATATATATGTCCCTGTACATATACAATGTGGGTGCTAATGTGGAGACTGTGGCCGGCCTGAGCCACC AAGCTGCGGGACCCAGAGGGAGGATTTTACTGCAAGTCAGCATCAAAGCACCGGTGTTATTCTGAAAACACCAGTGGCCTCATTTTTGGCTTTTGCAAAG CATGAATTTTTTCATTTGGATTGCACTTTCCTGGTTCATGACTGTACCTGTAGGTGGTTGTTACTTTGACTCTTTTCAGGAACCACCCCCCAAGCTGAAT TTACAAGTTCTGTTAGCACTATTTGCTTCAACTTACTGCGATTTGTTCTCAAAACTTAAAAATAAGCAAGCAAATGGCTGATACTACCAAGAGAACTGGA AGATGGATACCACACAAACTTCTTGTATAAAAATATGAATGCTGAAATGTTTCAGACATTTTTAATTTAATAAACCTGTAACCACATTTAAGTGATCTAA AACCCATAGCATTGTAGTCATGGCAACCCGCTAAACTTTCTCATGCAACTAAAATTTCTGGGGGAAATGAGGGTGGGGGTTGTACATTTCCCATTGTAAA ATAAGTGTTTTAAATGTCCTGTACTGCTAACGAATGACTTTCTATATGTCCAGGAGTTCTCCAGTGGAATAACTATGCACTACTTTACATTTCATGGGGA TGCACAAAAACAAAAAAGTATTACATTTTTAGTTGCTGTTTGTACCAACCTTAAATTACATATGTTTAACAACAACAAATCAAAAATCCTATTTCTATTG AGTTTTTAATACTGACTAGCAACTCTGAAGTCTTAATTCCTTTTTTGTTATGATTTATTTGTGAGTTTACATTTTTAAATTGTTTAACTTTCTTAATTTA GTAATTAAAAAGAGAGCATTTTACATTTGAA

FYN-F1 (forward primer)
FYN-R1 (reverse primer)
Single exon skipping

Frame 0

GAERGGDQRRSEELRREAYVKGI*IMGCVQCKD KEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSF GVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGT LRTRGGTGVTLFVALYDYEARTEDDLSFHKGEK FQILNSSEGDWWEARSLTTGETGYIPSNYVAPVD SIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLI RESETTKGAYSLSIRDWDDMKGDHVKHYKIRKL DNGGYYITTRAQFETLQQLVQHYSGTWNGNTKVA IKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY AVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALK LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANIL VGNGLICKIADFGLARLIEDNEYTARQGAKFPI KWTAPEAALYGRFTIKSDVWSFGILLTELVTKG RVPYPGMNNREVLEQVERGYRMPCPQDCPISLHE LMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQ YQPGENL*GPGLRREALSQRLPHPSPLAFNSVA SCSPAAEPPRIRLHVTLKLTNFHGPH**HLSPNP NLLCEAFETEPCYFSDFGKCIVSMLCKRPNLCS V*IVTPVPTILVLSFFKNANPM*F*LCLHLIQL KKKKYYFPKVASLSKTIKFFFMF*QKPIRTGVCF CFLFYKYEYI*YICPCTYTMWVLMWRLWPA*AT KLRDPEGGFYCKSASKHRCYSENTSGLIFGFCK A*IFSFGLHFPGS*LYL*VVVTLTLFRNHPPS*I YKFC*HYLLQLTAICSQNLKISKQMADTTKRTG RWIPHKLLV*KYEC*NVSDIFNLINL*PHLSDL KPIAL*SWQPAKLSHATKISGGNEGGGCTFPIVK *VF*MSCTANE*LSICPGVLQWNNYALLYISWG CTKTKKYYIFSCCLYQP*ITYV*QQQIKNPISI EFLILTSNSEVLIPFLL*FICEFTFLNCLTFLI* *LKREHFTFE

Frame 1

ELREGETSAGLRS*EGRLT*REFR*WAVCNVRI KKQQN*RRRGTAA*TRALGTAMAQTPPLSTTPA SV*PPSPTTTTSTQPGAKDSPSLEV*TLRLIRGP CVREEEQE*HSLWPFMTMKHGQKMT*VFTKEKN FKY*TARKEIGGKPAP*QLERQVTFPAIMWLQL TLSRQKSGTLENLAEKMLSDSYCPLETQEVPFLS ARVKPPKVPIHFLSVIGMI*KETMSNIIKFANL TMVDTTLPPGPSLKHFSSLYNITQVPGMETQK* P*RLLNQAQCPPNHSLRKRRS*RS*STTSWSSSM QWCLRSPSTSSPSI*TKEVYWIS*KMEKEEL*N YQILWTWQHRWLQEWLTSSA*IISIEICDQQTF *WGMDSYARLLTSDWPD**KTMSTQQDKVQSSPS SGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE ECHTQA*TTGRCWSRWSEATGCPARRTAPSLCM SS*STAGKRTLKNAPLLSTCRASWKTTLPRQSPS TNLVKTCKARVCGERPCPRGCPTPPH*LSIP*P AAPQQRNRPGSDCM*L*S*RTSMALINDTCPQI RTSSVKHSRQNLVISQTLENALYRCYVKGQTSVQ CK*LLQCQQS*CFPFLKMQILCDFNSVFT*FN* KKKSIIFQKWPLCLKQ*NFFSCFNKNQSGQVFV FVFFFINMNIYNIYVPVHIQCGC*CGDCGRPEPP SCGTQREDFTASQHQSTGVILKTPVASFLAFAK HEFFHLDCTFLVHDCTCRWLLL*LFSGTTPQAE FTSSVSTICFNLLRFVLKT*K*ASKWLILPRELE DGYHTNFLYKNMNAEMFQTFLI**TCNHI*VI* NP*HCSHGNPLNFLMQLKFLGEMRVGVVHFPL* NKCFKCPVLLTNDFLYVQEFSSGITMHYFTFHGD AQKQKSITFLVAVCTNLKLHMFNNNKSKILFLL SF*Y*LATLKS*FLFCYDLFVSLHF*IV*LS*F SN*KESILHL

Frame 2

S*ERGRPAQV*GAEKGGLREGNLDNGLCAM*G* RSNKTDGGEGRQPEPELWVPLWHRPHPSALPQL RCDLHPQLQQLPRSRGPRTHRLWRCELFVSYGD LAYERRNRSDTLCGPL*L*STDRR*PEFSQRRKI SNIEQLGRRLVGSPLLDNWRDRLHSQQLCGSS* LYPGRRVVLWKTWPKRC*ATAIVLWKPKRYLSY PRE*NHQRCLFTFYP*LG*YERRPCQTL*NSQT* QWWILHYHPGPV*NTSAACTTLLRYLEWKHKSS HKDS*TRHNVPRIIP*GSADHEEAEARQAGPAL CSGV*GAHLHRHRVYEQRKFTGFLKRWRRKSSEI TKSCGHGSTGGCRNGLHRAHELYP*RSAISKHS SGEWTHMQDC*LRIGPIDRRQ*VHSKTRCKVPH QVDGPRGSPVREVHNQV*RVVFWNLTHRAGHQRK SAIPRHEQPGGAGAGGARLQDALPAGLPHLSA* AHDPLLEKGP*RTPHF*VLAELPGRLLYRDRAP VPTW*KPVRPGSAERGLVPEAAPPLPISFQFRSQ LLPSSGTAQDQIACDSEADELPWPSLMTLVPKS EPPL*SIRDRTLLFLRLWKMHCIDVM*KAKPLF SVNSYSSANNPSAFLF*KCKSYVILTLSSPDSTK KKKVLFSKSGLFV*NNKIFFHVLTKTNQDRCLF LFSFL*I*IYIIYMSLYIYNVGANVETVAGLSH QAAGPRGRILLQVSIKAPVLF*KHQWPHFWLLQS MNFFIWIALSWFMTVPVGGCYFDSFQEPPPKLN LQVLLALFASTYCDLFSKLKNKQANG*YYQENW KMDTTQTSCIKI*MLKCFRHF*FNKPVTTFK*SK THSIVVMATR*TFSCN*NFWGK*GWGLYISHCK ISVLNVLYC*RMTFYMSRSSPVE*LCTTLHFMG MHKNKKVLHF*LLFVPTLNYICLTTTNQKSYFY* VFNTD*QL*SLNSFFVMIYL*VYIFKLFNFLNL VIKKRAFYI*

Sequence FYN.gAug05

CATGTCGTTGACTGCAGGCTGGTGGAAGGTTCTGCAGATACTCAGTGGATGTCAGAGCCGCAGCGCCACATCCATGGCCTCCCCGATGTTAATGGGAAGA GGTACACACTCCATTCCTGCTCTTCATCACAGGGAAGGAGATTGGTGGGAAGCCCGCTCCTTGACAACTGGAGAGACAGGTTACATTCCCAGCAATTATG TGGCTCCAGTTGACTCTATCCAGGCAGAAGAGTGGTACTTTGGAAAACTTGGCCGAAAAGATGCTGAGCGACAGCTATTGTCCTTTGGAAACCCAAGAGG TACCTTTCTTATCCGCGAGAGTGAAACCACCAAAGGTGCCTATTCACTTTCTATCCGTGATTGGGATGATATGAAAGGAGACCATGTCAAACATTATAAA ATTCGCAAACTTGACAATGGTGGATACTACATTACCACCCGGGCCCAGTTTGAAACACTTCAGCAGCTTGTACAACATTACTCAGAGAGAGCTGCAGGTC TCTGCTGCCGCCTAGTAGTTCCCTGTCACAAAGGGATGCCAAGGCTTACCGATCTGTCTGTCAAAACCAAAGATGTCTGGGAAATCCCTCGAGAATCCCT GCAGTTGATCAAGAGACTGGGAAATGGGCAGTTTGGGGAAGTATGGATGGGTACCTGGAATGGAAACACAAAAGTAGCCATAAAGACTCTTAAACCAGGC ACAATGTCCCCCGAATCATTCCTTGAGGAAGCGCAGATCATGAAGAAGCTGAAGCACGACAAGCTGGTCCAGCTCTATGCAGTGGTGTCTGAGGAGCCCA TCTACATCGTCACCGAGTATATGAACAAAGGTTGGGCAACACCTCTCCTGTCTCCAGCTCACAGTGCCTTAAGGGGTTGTTTAGGGGAGAGAAATGGAAG TTTCCTACTTGCTACTTTTCTAGTTTCTGCCTGGGTCAAGTATTCCCATTAGGAACCACCAGTTATGTGCTCGTTAATGAAAACATTTTTTAAAACAGAC TAACCTTGCGTTTACCCCACCCCAAATCCTTATGAAATGCCAAATACTTTTTACATGTTATGTGTGTCAGAAATTCAAGCTCCTCTCC

FYN-F1 (forward primer)
FYN-R1 (reverse primer)
Single exon skipping

Frame 0

HVVDCRLVEGSADTQWMSEPQRHIHGLPDVNGK RYTLHSCSSSQGRRLVGSPLLDNWRDRLHSQQLC GSS*LYPGRRVVLWKTWPKRC*ATAIVLWKPKR YLSYPRE*NHQRCLFTFYP*LG*YERRPCQTL* NSQT*QWWILHYHPGPV*NTSAACTTLLRESCRS LLPPSSSLSQRDAKAYRSVCQNQRCLGNPSRIP AVDQETGKWAVWGSMDGYLEWKHKSSHKDS*TR HNVPRIIP*GSADHEEAEARQAGPALCSGV*GAH LHRHRVYEQRLGNTSPVSSSQCLKGLFRGEKWK FPTCYFSSFCLGQVFPLGTTSYVLVNENIF*NR LTLRLPHPKSL*NAKYFLHVMCVRNSSSS

Frame 1

MSLTAGWWKVLQILSGCQSRSATSMASPMLMGR GTHSIPALHHREGDWWEARSLTTGETGYIPSNY VAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRG TFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK IRKLDNGGYYITTRAQFETLQQLVQHYSERAAG LCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESL QLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPG TMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEP IYIVTEYMNKGWATPLLSPAHSALRGCLGERNGS FLLATFLVSAWVKYSH*EPPVMCSLMKTFFKTD *PCVYPTPNPYEMPNTFYMLCVSEIQAPL

Frame 2

CR*LQAGGRFCRYSVDVRAAAPHPWPPRC*WEE VHTPFLLFITGKEIGGKPAP*QLERQVTFPAIM WLQLTLSRQKSGTLENLAEKMLSDSYCPLETQE VPFLSARVKPPKVPIHFLSVIGMI*KETMSNIIK FANLTMVDTTLPPGPSLKHFSSLYNITQRELQV SAAA**FPVTKGCQGLPICLSKPKMSGKSLENP CS*SRDWEMGSLGKYGWVPGMETQK*P*RLLNQA QCPPNHSLRKRRS*RS*STTSWSSSMQWCLRSP STSSPSI*TKVGQHLSCLQLTVP*GVV*GREME VSYLLLF*FLPGSSIPIRNHQLCAR**KHFLKQT NLAFTPPQILMKCQILFTCYVCQKFKLLS

Sequence FYN.eAug05

ATTTCCCCTTGTGTAATAATCTCCCTTCTTGTGAATTTCGTTTCGGCAGGAGTGACACTCTTTGTGGCCCTTTATGACTATGAAGCACGGACAGAAGATG ACCTGAGTTTTCACAAAGGAGAAAAATTTCAAATATTGAACAGCTCGGAAGGAGATTGGTGGGAAGCCCGCTCCTTGACAACTGGAGAGACAGGTTACAT TCCCAGCAATTATGTGGCTCCAGTTGACTCTATCCAGGCAGAAGAGTGGTACTTTGGAAAACTTGGCCGAAAAGATGCTGAGCGACAGCTATTGTCCTTT GGAAACCCAAGAGGTACCTTTCTTATCCGCGAGAGTGAAACCACCAAAGGTGCCTATTCACTTTCTATCCGTGATTGGGATGATATGAAAGGAGACCATG TCAAACATTATAAAATTCGCAAACTTGACAATGGTGGATACTACATTACCACCCGGGCCCAGTTTGAAACACTTCAGCAGCTTGTACAACATTACTCAGA GAGAGCTGCAGGTCTCTGCTGCCGCCTAGTAGTTCCCTGTCACAAAGGGATGCCAAGGCTTACCGATCTGTCTGTCAAAACCAAAGATGTCTGGGAAATC CCTCGAGAATCCCTGCAGTTGATCAAGAGACTGGGAAATGGGCAGTTTGGGGAAGTATGGATGGGTACCTGGAATGGAAACACAAAAGTAGCCATAAAGA CTCTTAAACCAGGCACAATGTCCCCCGAATCATTCCTTGAGGAAGCGCAGATCATGAAGAAGCTGAAGCACGACAAGCTGGTCCAGCTCTATGCAGTGGT GTCTGAGGAGCCCATCTACATCGTCACCGAGTATATGAACAAAGGTTGGGCAACACCTCTCCTGTCTCCAGCTCACAGTGCCTTAAGGGGTTGTTTAGGG GAGAGAAATGGAAGTTTCCTACTTGCTACTTTTCTAGTTTCTGCCTGGGTCAAGTATTCCCATTAGGAACCACCAGTTATGTGCTCGTTAATGAAAACAT TTTTTAAAACAGACTAACCTTGCGTTTACCCCACCCCAAATCCTTATGAAATGCCAAATACTTTTTACATGTTATGTGTGTCAGAAATTCAAGCTCCTCT CC

FYN-F1 (forward primer)
FYN-R1 (reverse primer)
Single exon skipping

Frame 0

ISPCVIISLLVNFVSAGVTLFVALYDYEARTED DLSFHKGEKFQILNSSEGDWWEARSLTTGETGYI PSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSF GNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH VKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSE RAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEI PRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIK TLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVV SEEPIYIVTEYMNKGWATPLLSPAHSALRGCLG ERNGSFLLATFLVSAWVKYSH*EPPVMCSLMKT FFKTD*PCVYPTPNPYEMPNTFYMLCVSEIQAPL

Frame 1

FPLV**SPFL*ISFRQE*HSLWPFMTMKHGQKM T*VFTKEKNFKY*TARKEIGGKPAP*QLERQVT FPAIMWLQLTLSRQKSGTLENLAEKMLSDSYCPL ETQEVPFLSARVKPPKVPIHFLSVIGMI*KETM SNIIKFANLTMVDTTLPPGPSLKHFSSLYNITQ RELQVSAAA**FPVTKGCQGLPICLSKPKMSGKS LENPCS*SRDWEMGSLGKYGWVPGMETQK*P*R LLNQAQCPPNHSLRKRRS*RS*STTSWSSSMQW CLRSPSTSSPSI*TKVGQHLSCLQLTVP*GVV*G REMEVSYLLLF*FLPGSSIPIRNHQLCAR**KH FLKQTNLAFTPPQILMKCQILFTCYVCQKFKLL S

Frame 2

FPLCNNLPSCEFRFGRSDTLCGPL*L*STDRR* PEFSQRRKISNIEQLGRRLVGSPLLDNWRDRLH SQQLCGSS*LYPGRRVVLWKTWPKRC*ATAIVL WKPKRYLSYPRE*NHQRCLFTFYP*LG*YERRPC QTL*NSQT*QWWILHYHPGPV*NTSAACTTLLR ESCRSLLPPSSSLSQRDAKAYRSVCQNQRCLGN PSRIPAVDQETGKWAVWGSMDGYLEWKHKSSHKD S*TRHNVPRIIP*GSADHEEAEARQAGPALCSG V*GAHLHRHRVYEQRLGNTSPVSSSQCLKGLFR GEKWKFPTCYFSSFCLGQVFPLGTTSYVLVNENI F*NRLTLRLPHPKSL*NAKYFLHVMCVRNSSSS

Sequence FYN.aAug05

GCTGGAGGGGCAGAGCATCAGCAAGAGTAGCAGCGAGCAGCCGCGCTGGTGGCGGCGGCGCGTCGTTGCAGTTGCGCCATCTGTCAGGAGCGGAGCCGGC GAGGAGGGGGCTGCCGCGGGCGAGGAGGAGGGGTCGCCGCGAGCCGAAGGCCTTCGAGACCCGCCCGCCGCCCGGCGGCGAGAGTAGAGGCGAGGTTGTT GTGCGAGCGGCGCGTCCTCTCCCGCCCGGGCGCGCCGCGCTTCTCCCAGCGCACCGAGGACCGCCCGGGCGCACACAAAGCCGCCGCCCGCGCCGCACCG CCCGGCGGCCGCCGCCCGCGCCAGGGAGGGATTCGGCCGCCGGGCCGGGGACACCCCGGCGCCGCCCCCTCGGTGCTCTCGGAAGGCCCACCGGCTCCCG GGCCCGCCGGGGACCCCCCGGAGCCGCCTCGGCCGCGCCGGAGGAGGGCGGGGAGAGGACCATGTGAGTGGGCTCCGGAGCCTCAGCGCCGCGCAGTTTT TTTGAAGAAGCAGGATGCTGATCTAAACGTGGAAAAAGACCAGTCCTGCCTCTGTTGTAGAAGACATGTGGTGTATATAAAGTTTGTGATCGTTGGCGGA CATTTTGGAATTTAGATAATGGGCTGTGTGCAATGTAAGGATAAAGAAGCAACAAAACTGACGGAGGAGAGGGACGGCAGCCTGAACCAGAGCTCTGGGT ACCGCTATGGCACAGACCCCACCCCTCAGCACTACCCCAGCTTCGGTGTGACCTCCATCCCCAACTACAACAACTTCCACGCAGCCGGGGGCCAAGGACT CACCGTCTTTGGAGGTGTGAACTCTTCGTCTCATACGGGGACCTTGCGTACGAGAGGAGGAACAGGAGTGACACTCTTTGTGGCCCTTTATGACTATGAA GCACGGACAGAAGATGACCTGAGTTTTCACAAAGGAGAAAAATTTCAAATATTGAACAGCTCGGAAGGAGATTGGTGGGAAGCCCGCTCCTTGACAACTG GAGAGACAGGTTACATTCCCAGCAATTATGTGGCTCCAGTTGACTCTATCCAGGCAGAAGAGTGGTACTTTGGAAAACTTGGCCGAAAAGATGCTGAGCG ACAGCTATTGTCCTTTGGAAACCCAAGAGGTACCTTTCTTATCCGCGAGAGTGAAACCACCAAAGGTGCCTATTCACTTTCTATCCGTGATTGGGATGAT ATGAAAGGAGACCATGTCAAACATTATAAAATTCGCAAACTTGACAATGGTGGATACTACATTACCACCCGGGCCCAGTTTGAAACACTTCAGCAGCTTG TACAACATTACTCAGAGAGAGCTGCAGGTCTCTGCTGCCGCCTAGTAGTTCCCTGTCACAAAGGGATGCCAAGGCTTACCGATCTGTCTGTCAAAACCAA AGATGTCTGGGAAATCCCTCGAGAATCCCTGCAGTTGATCAAGAGACTGGGAAATGGGCAGTTTGGGGAAGTATGGATGGGTACCTGGAATGGAAACACA AAAGTAGCCATAAAGACTCTTAAACCAGGCACAATGTCCCCCGAATCATTCCTTGAGGAAGCGCAGATCATGAAGAAGCTGAAGCACGACAAGCTGGTCC AGCTCTATGCAGTGGTGTCTGAGGAGCCCATCTACATCGTCACCGAGTATATGAACAAAGGAAGTTTACTGGATTTCTTAAAAGATGGAGAAGGAAGAGC TCTGAAATTACCAAATCTTGTGGACATGGCAGCACAGGTGGCTGCAGGAATGGCTTACATCGAGCGCATGAATTATATCCATAGAGATCTGCGATCAGCA AACATTCTAGTGGGGAATGGACTCATATGCAAGATTGCTGACTTCGGATTGGCCCGATTGATAGAAGACAATGAGTACACAGCAAGACAAGGTGCAAAGT TCCCCATCAAGTGGACGGCCCCCGAGGCAGCCCTGTACGGGAGGTTCACAATCAAGTCTGACGTGTGGTCTTTTGGAATCTTACTCACAGAGCTGGTCAC CAAAGGAAGAGTGCCATACCCAGGCATGAACAACCGGGAGGTGCTGGAGCAGGTGGAGCGAGGCTACAGGATGCCCTGCCCGCAGGACTGCCCCATCTCT CTGCATGAGCTCATGATCCACTGCTGGAAAAAGGACCCTGAAGAACGCCCCACTTTTGAGTACTTGCAGAGCTTCCTGGAAGACTACTTTACCGCGACAG AGCCCCAGTACCAACCTGGTGAAAACCTGTAAGGCCCGGGTCTGCGGAGAGAGGCCTTGTCCCAGAGGCTGCCCCACCCCTCCCCATTAGCTTTCAATTC CGTAGCCAGCTGCTCCCCAGCAGCGGAACCGCCCAGGATCAGATTGCATGTGACTCTGAAGCTGACGAACTTCCATGGCCCTCATTAATGACACTTGTCC CCAAATCCGAACCTCCTCTGTGAAGCATTCGAGACAGAACCTTGTTATTTCTCAGACTTTGGAAAATGCATTGTATCGATGTTATGTAAAAGGCCAAACC TCTGTTCAGTGTAAATAGTTACTCCAGTGCCAACAATCCTAGTGCTTTCCTTTTTTAAAAATGCAAATCCTATGTGATTTTAACTCTGTCTTCACCTGAT TCAACTAAAAAAAAAAAAGTATTATTTTCCAAAAGTGGCCTCTTTGTCTAAAACAATAAAATTTTTTTTCATGTTTTAACAAAAACCAATCAGGACAGGT GTTTGTTTTTGTTTTCTTTTTTATAAATATGAATATATATAATATATATGTCCCTGTACATATACAATGTGGGTGCTAATGTGGAGACTGTGGCCGGCCT GAGCCACCAAGCTGCGGGACCCAGAGGGAGGATTTTACTGCAAGTCAGCATCAAAGCACCGGTGTTATTCTGAAAACACCAGTGGCCTCATTTTTGGCTT TTGCAAAGCATGAATTTTTTCATTTGGATTGCACTTTCCTGGTTCATGACTGTACCTGTAGGTGGTTGTTACTTTGACTCTTTTCAGGAACCACCCCCCA AGCTGAATTTACAAGTTCTGTTAGCACTATTTGCTTCAACTTACTGCGATTTGTTCTCAAAACTTAAAAATAAGCAAGCAAATGGCTGATACTACCAAGA GAACTGGAAGATGGATACCACACAAACTTCTTGTATAAAAATATGAATGCTGAAATGTTTCAGACATTTTTAATTTAATAAACCTGTAACCACATTTAAG TGATCTAAAACCCATAGCATTGTAGTCATGGCAACCCGCTAAACTTTCTCATGCAACTAAAATTTCTGGGGGAAATGAGGGTGGGGGTTGTACATTTCCC ATTGTAAAATAAGTGTTTTAAATGTCCTGTACTGCTAACGAATGACTTTCTATATGTCCAGGAGTTCTCCAGTGGAATAACTATGCACTACTTTACATTT CATGGGGATGCACAAAAACAAAAAAGTATTACATTTTTAGTTGCTGTTTGTACCAACCTTAAATTACATATGTTTAACAACAACAAATCAAAAATCCTAT TTCTATTGAGTTTTTAATACTGACTAGCAACTCTGAAGTCTTAATTCCTTTTTTGTTATGATTTATTTGTGAGTTTACATTTTTAAATTGTTTAACTTTC TTAATTTAGTAATTAAAAAGAGAGCATTTTACATTTGAA

FYN-F1 (forward primer)
FYN-R1 (reverse primer)
Single exon skipping

Frame 0

AGGAEHQQE*QRAAALVAAARRCSCAICQERSR RGGGCRGRGGGVAASRRPSRPARRPAARVEARLL CERRVLSRPGAPRFSQRTEDRPGAHKAAARAAP PGGRRPRQGGIRPPGRGHPGAAPSVLSEGPPAP GPAGDPPEPPRPRRRRAGRGPCEWAPEPQRRAVF LKKQDADLNVEKDQSCLCCRRHVVYIKFVIVGG HFGI*IMGCVQCKDKEATKLTEERDGSLNQSSG YRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGL TVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYE ARTEDDLSFHKGEKFQILNSSEGDWWEARSLTT GETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAER QLLSFGNPRGTFLIRESETTKGAYSLSIRDWDD MKGDHVKHYKIRKLDNGGYYITTRAQFETLQQL VQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTK DVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNT KVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLV QLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRA LKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSA NILVGNGLICKIADFGLARLIEDNEYTARQGAK FPIKWTAPEAALYGRFTIKSDVWSFGILLTELVT KGRVPYPGMNNREVLEQVERGYRMPCPQDCPIS LHELMIHCWKKDPEERPTFEYLQSFLEDYFTAT EPQYQPGENL*GPGLRREALSQRLPHPSPLAFNS VASCSPAAEPPRIRLHVTLKLTNFHGPH**HLS PNPNLLCEAFETEPCYFSDFGKCIVSMLCKRPN LCSV*IVTPVPTILVLSFFKNANPM*F*LCLHLI QLKKKKYYFPKVASLSKTIKFFFMF*QKPIRTG VCFCFLFYKYEYI*YICPCTYTMWVLMWRLWPA *ATKLRDPEGGFYCKSASKHRCYSENTSGLIFGF CKA*IFSFGLHFPGS*LYL*VVVTLTLFRNHPP S*IYKFC*HYLLQLTAICSQNLKISKQMADTTK RTGRWIPHKLLV*KYEC*NVSDIFNLINL*PHLS DLKPIAL*SWQPAKLSHATKISGGNEGGGCTFP IVK*VF*MSCTANE*LSICPGVLQWNNYALLYI SWGCTKTKKYYIFSCCLYQP*ITYV*QQQIKNPI SIEFLILTSNSEVLIPFLL*FICEFTFLNCLTF LI**LKREHFTFE

Frame 1

LEGQSISKSSSEQPRWWRRRVVAVAPSVRSGAG EEGAAAGEEEGSPRAEGLRDPPAARRRE*RRGC CASGASSPARARRASPSAPRTARAHTKPPPAPHR PAAAARAREGFGRRAGDTPAPPPRCSRKAHRLP GPPGTPRSRLGRAGGGRGEDHVSGLRSLSAAQF F*RSRMLI*TWKKTSPASVVEDMWCI*SL*SLAD ILEFR*WAVCNVRIKKQQN*RRRGTAA*TRALG TAMAQTPPLSTTPASV*PPSPTTTTSTQPGAKD SPSLEV*TLRLIRGPCVREEEQE*HSLWPFMTMK HGQKMT*VFTKEKNFKY*TARKEIGGKPAP*QL ERQVTFPAIMWLQLTLSRQKSGTLENLAEKMLS DSYCPLETQEVPFLSARVKPPKVPIHFLSVIGMI *KETMSNIIKFANLTMVDTTLPPGPSLKHFSSL YNITQRELQVSAAA**FPVTKGCQGLPICLSKP KMSGKSLENPCS*SRDWEMGSLGKYGWVPGMETQ K*P*RLLNQAQCPPNHSLRKRRS*RS*STTSWS SSMQWCLRSPSTSSPSI*TKEVYWIS*KMEKEE L*NYQILWTWQHRWLQEWLTSSA*IISIEICDQQ TF*WGMDSYARLLTSDWPD**KTMSTQQDKVQS SPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWS PKEECHTQA*TTGRCWSRWSEATGCPARRTAPSL CMSS*STAGKRTLKNAPLLSTCRASWKTTLPRQ SPSTNLVKTCKARVCGERPCPRGCPTPPH*LSI P*PAAPQQRNRPGSDCM*L*S*RTSMALINDTCP QIRTSSVKHSRQNLVISQTLENALYRCYVKGQT SVQCK*LLQCQQS*CFPFLKMQILCDFNSVFT* FN*KKKSIIFQKWPLCLKQ*NFFSCFNKNQSGQV FVFVFFFINMNIYNIYVPVHIQCGC*CGDCGRP EPPSCGTQREDFTASQHQSTGVILKTPVASFLA FAKHEFFHLDCTFLVHDCTCRWLLL*LFSGTTPQ AEFTSSVSTICFNLLRFVLKT*K*ASKWLILPR ELEDGYHTNFLYKNMNAEMFQTFLI**TCNHI* VI*NP*HCSHGNPLNFLMQLKFLGEMRVGVVHFP L*NKCFKCPVLLTNDFLYVQEFSSGITMHYFTF HGDAQKQKSITFLVAVCTNLKLHMFNNNKSKIL FLLSF*Y*LATLKS*FLFCYDLFVSLHF*IV*LS *FSN*KESILHL

Frame 2

WRGRASARVAASSRAGGGGASLQLRHLSGAEPA RRGLPRARRRGRREPKAFETRPPPGGESRGEVV VRAARPLPPGRAALLPAHRGPPGRTQSRRPRRT ARRPPPAPGRDSAAGPGTPRRRPLGALGRPTGSR ARRGPPGAASAAPEEGGERTM*VGSGASAPRSF FEEAGC*SKRGKRPVLPLL*KTCGVYKVCDRWR TFWNLDNGLCAM*G*RSNKTDGGEGRQPEPELWV PLWHRPHPSALPQLRCDLHPQLQQLPRSRGPRT HRLWRCELFVSYGDLAYERRNRSDTLCGPL*L* STDRR*PEFSQRRKISNIEQLGRRLVGSPLLDNW RDRLHSQQLCGSS*LYPGRRVVLWKTWPKRC*A TAIVLWKPKRYLSYPRE*NHQRCLFTFYP*LG* YERRPCQTL*NSQT*QWWILHYHPGPV*NTSAAC TTLLRESCRSLLPPSSSLSQRDAKAYRSVCQNQ RCLGNPSRIPAVDQETGKWAVWGSMDGYLEWKH KSSHKDS*TRHNVPRIIP*GSADHEEAEARQAGP ALCSGV*GAHLHRHRVYEQRKFTGFLKRWRRKS SEITKSCGHGSTGGCRNGLHRAHELYP*RSAIS KHSSGEWTHMQDC*LRIGPIDRRQ*VHSKTRCKV PHQVDGPRGSPVREVHNQV*RVVFWNLTHRAGH QRKSAIPRHEQPGGAGAGGARLQDALPAGLPHL SA*AHDPLLEKGP*RTPHF*VLAELPGRLLYRDR APVPTW*KPVRPGSAERGLVPEAAPPLPISFQF RSQLLPSSGTAQDQIACDSEADELPWPSLMTLV PKSEPPL*SIRDRTLLFLRLWKMHCIDVM*KAKP LFSVNSYSSANNPSAFLF*KCKSYVILTLSSPD STKKKKVLFSKSGLFV*NNKIFFHVLTKTNQDR CLFLFSFL*I*IYIIYMSLYIYNVGANVETVAGL SHQAAGPRGRILLQVSIKAPVLF*KHQWPHFWL LQSMNFFIWIALSWFMTVPVGGCYFDSFQEPPP KLNLQVLLALFASTYCDLFSKLKNKQANG*YYQE NWKMDTTQTSCIKI*MLKCFRHF*FNKPVTTFK *SKTHSIVVMATR*TFSCN*NFWGK*GWGLYIS HCKISVLNVLYC*RMTFYMSRSSPVE*LCTTLHF MGMHKNKKVLHF*LLFVPTLNYICLTTTNQKSY FY*VFNTD*QL*SLNSFFVMIYL*VYIFKLFNF LNLVIKKRAFYI*