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Sequences

Sequence FYN.bAug05

GCTGGAGGGGCAGAGCATCAGCAAGAGTAGCAGCGAGCAGCCGCGCTGGTGGCGGCGGCGCGTCGTTGCAGTTGCGCCATCTGTCAGGAGCGGAGCCGGC GAGGAGGGGGCTGCCGCGGGCGAGGAGGAGGGGTCGCCGCGAGCCGAAGGCCTTCGAGACCCGCCCGCCGCCCGGCGGCGAGAGTAGAGGCGAGGTTGTT GTGCGAGCGGCGCGTCCTCTCCCGCCCGGGCGCGCCGCGCTTCTCCCAGCGCACCGAGGACCGCCCGGGCGCACACAAAGCCGCCGCCCGCGCCGCACCG CCCGGCGGCCGCCGCCCGCGCCAGGGAGGGATTCGGCCGCCGGGCCGGGGACACCCCGGCGCCGCCCCCTCGGTGCTCTCGGAAGGCCCACCGGCTCCCG GGCCCGCCGGGGACCCCCCGGAGCCGCCTCGGCCGCGCCGGAGGAGGGCGGGGAGAGGACCATGTGAGTGGGCTCCGGAGCCTCAGCGCCGCGCAGGACC AGTCCTGCCTCTGTTGTAGAAGACATGTGGTGTATATAAAGTTTGTGATCGTTGGCGGACATTTTGGAATTTAGATAATGGGCTGTGTGCAATGTAAGGA TAAAGAAGCAACAAAACTGACGGAGGAGAGGGACGGCAGCCTGAACCAGAGCTCTGGGTACCGCTATGGCACAGACCCCACCCCTCAGCACTACCCCAGC TTCGGTGTGACCTCCATCCCCAACTACAACAACTTCCACGCAGCCGGGGGCCAAGGACTCACCGTCTTTGGAGGTGTGAACTCTTCGTCTCATACGGGGA CCTTGCGTACGAGAGGAGGAACAGGAGTGACACTCTTTGTGGCCCTTTATGACTATGAAGCACGGACAGAAGATGACCTGAGTTTTCACAAAGGAGAAAA ATTTCAAATATTGAACAGCTCGGAAGGAGATTGGTGGGAAGCCCGCTCCTTGACAACTGGAGAGACAGGTTACATTCCCAGCAATTATGTGGCTCCAGTT GACTCTATCCAGGCAGAAGAGTGGTACTTTGGAAAACTTGGCCGAAAAGATGCTGAGCGACAGCTATTGTCCTTTGGAAACCCAAGAGGTACCTTTCTTA TCCGCGAGAGTGAAACCACCAAAGGTGCCTATTCACTTTCTATCCGTGATTGGGATGATATGAAAGGAGACCATGTCAAACATTATAAAATTCGCAAACT TGACAATGGTGGATACTACATTACCACCCGGGCCCAGTTTGAAACACTTCAGCAGCTTGTACAACATTACTCAGAGAAAGCTGATGGTTTGTGTTTTAAC TTAACTGTGATTGCATCGAGTTGTACCCCACAAACTTCTGGATTGGCTAAAGATGCTTGGGAAGTTGCACGTCGTTCGTTGTGTCTGGAGAAGAAGCTGG GTCAGGGGTGTTTCGCTGAAGTGTGGCTTGGTACCTGGAATGGAAACACAAAAGTAGCCATAAAGACTCTTAAACCAGGCACAATGTCCCCCGAATCATT CCTTGAGGAAGCGCAGATCATGAAGAAGCTGAAGCACGACAAGCTGGTCCAGCTCTATGCAGTGGTGTCTGAGGAGCCCATCTACATCGTCACCGAGTAT ATGAACAAAGGAAGTTTACTGGATTTCTTAAAAGATGGAGAAGGAAGAGCTCTGAAATTACCAAATCTTGTGGACATGGCAGCACAGGTGGCTGCAGGAA TGGCTTACATCGAGCGCATGAATTATATCCATAGAGATCTGCGATCAGCAAACATTCTAGTGGGGAATGGACTCATATGCAAGATTGCTGACTTCGGATT GGCCCGATTGATAGAAGACAATGAGTACACAGCAAGACAAGGTGCAAAGTTCCCCATCAAGTGGACGGCCCCCGAGGCAGCCCTGTACGGGAGGTTCACA ATCAAGTCTGACGTGTGGTCTTTTGGAATCTTACTCACAGAGCTGGTCACCAAAGGAAGAGTGCCATACCCAGGCATGAACAACCGGGAGGTGCTGGAGC AGGTGGAGCGAGGCTACAGGATGCCCTGCCCGCAGGACTGCCCCATCTCTCTGCATGAGCTCATGATCCACTGCTGGAAAAAGGACCCTGAAGAACGCCC CACTTTTGAGTACTTGCAGAGCTTCCTGGAAGACTACTTTACCGCGACAGAGCCCCAGTACCAACCTGGTGAAAACCTGTAAGGCCCGGGTCTGCGGAGA GAGGCCTTGTCCCAGAGGCTGCCCCACCCCTCCCCATTAGCTTTCAATTCCGTAGCCAGCTGCTCCCCAGCAGCGGAACCGCCCAGGATCAGATTGCATG TGACTCTGAAGCTGACGAACTTCCATGGCCCTCATTAATGACACTTGTCCCCAAATCCGAACCTCCTCTGTGAAGCATTCGAGACAGAACCTTGTTATTT CTCAGACTTTGGAAAATGCATTGTATCGATGTTATGTAAAAGGCCAAACCTCTGTTCAGTGTAAATAGTTACTCCAGTGCCAACAATCCTAGTGCTTTCC TTTTTTAAAAATGCAAATCCTATGTGATTTTAACTCTGTCTTCACCTGATTCAACTAAAAAAAAAAAAGTATTATTTTCCAAAAGTGGCCTCTTTGTCTA AAACAATAAAATTTTTTTTCATGTTTTAACAAAAACCAATCAGGACAGGTGTTTGTTTTTGTTTTCTTTTTTATAAATATGAATATATATAATATATATG TCCCTGTACATATACAATGTGGGTGCTAATGTGGAGACTGTGGCCGGCCTGAGCCACCAAGCTGCGGGACCCAGAGGGAGGATTTTACTGCAAGTCAGCA TCAAAGCACCGGTGTTATTCTGAAAACACCAGTGGCCTCATTTTTGGCTTTTGCAAAGCATGAATTTTTTCATTTGGATTGCACTTTCCTGGTTCATGAC TGTACCTGTAGGTGGTTGTTACTTTGACTCTTTTCAGGAACCACCCCCCAAGCTGAATTTACAAGTTCTGTTAGCACTATTTGCTTCAACTTACTGCGAT TTGTTCTCAAAACTTAAAAATAAGCAAGCAAATGGCTGATACTACCAAGAGAACTGGAAGATGGATACCACACAAACTTCTTGTATAAAAATATGAATGC TGAAATGTTTCAGACATTTTTAATTTAATAAACCTGTAACCACATTTAAGTGATCTAAAACCCATAGCATTGTAGTCATGGCAACCCGCTAAACTTTCTC ATGCAACTAAAATTTCTGGGGGAAATGAGGGTGGGGGTTGTACATTTCCCATTGTAAAATAAGTGTTTTAAATGTCCTGTACTGCTAACGAATGACTTTC TATATGTCCAGGAGTTCTCCAGTGGAATAACTATGCACTACTTTACATTTCATGGGGATGCACAAAAACAAAAAAGTATTACATTTTTAGTTGCTGTTTG TACCAACCTTAAATTACATATGTTTAACAACAACAAATCAAAAATCCTATTTCTATTGAGTTTTTAATACTGACTAGCAACTCTGAAGTCTTAATTCCTT TTTTGTTATGATTTATTTGTGAGTTTACATTTTTAAATTGTTTAACTTTCTTAATTTAGTAATTAAAAAGAGAGCATTTTACATTTGAA

FYN-F1 (forward primer)
FYN-R1 (reverse primer)
Mutually exclusive exon skipping

Frame 0

AGGAEHQQE*QRAAALVAAARRCSCAICQERSR RGGGCRGRGGGVAASRRPSRPARRPAARVEARLL CERRVLSRPGAPRFSQRTEDRPGAHKAAARAAP PGGRRPRQGGIRPPGRGHPGAAPSVLSEGPPAP GPAGDPPEPPRPRRRRAGRGPCEWAPEPQRRAGP VLPLL*KTCGVYKVCDRWRTFWNLDNGLCAM*G *RSNKTDGGEGRQPEPELWVPLWHRPHPSALPQ LRCDLHPQLQQLPRSRGPRTHRLWRCELFVSYGD LAYERRNRSDTLCGPL*L*STDRR*PEFSQRRK ISNIEQLGRRLVGSPLLDNWRDRLHSQQLCGSS *LYPGRRVVLWKTWPKRC*ATAIVLWKPKRYLSY PRE*NHQRCLFTFYP*LG*YERRPCQTL*NSQT *QWWILHYHPGPV*NTSAACTTLLRES*WFVF* LNCDCIELYPTNFWIG*RCLGSCTSFVVSGEEAG SGVFR*SVAWYLEWKHKSSHKDS*TRHNVPRII P*GSADHEEAEARQAGPALCSGV*GAHLHRHRV YEQRKFTGFLKRWRRKSSEITKSCGHGSTGGCRN GLHRAHELYP*RSAISKHSSGEWTHMQDC*LRI GPIDRRQ*VHSKTRCKVPHQVDGPRGSPVREVH NQV*RVVFWNLTHRAGHQRKSAIPRHEQPGGAGA GGARLQDALPAGLPHLSA*AHDPLLEKGP*RTP HF*VLAELPGRLLYRDRAPVPTW*KPVRPGSAE RGLVPEAAPPLPISFQFRSQLLPSSGTAQDQIAC DSEADELPWPSLMTLVPKSEPPL*SIRDRTLLF LRLWKMHCIDVM*KAKPLFSVNSYSSANNPSAF LF*KCKSYVILTLSSPDSTKKKKVLFSKSGLFV* NNKIFFHVLTKTNQDRCLFLFSFL*I*IYIIYM SLYIYNVGANVETVAGLSHQAAGPRGRILLQVS IKAPVLF*KHQWPHFWLLQSMNFFIWIALSWFMT VPVGGCYFDSFQEPPPKLNLQVLLALFASTYCD LFSKLKNKQANG*YYQENWKMDTTQTSCIKI*M LKCFRHF*FNKPVTTFK*SKTHSIVVMATR*TFS CN*NFWGK*GWGLYISHCKISVLNVLYC*RMTF YMSRSSPVE*LCTTLHFMGMHKNKKVLHF*LLF VPTLNYICLTTTNQKSYFY*VFNTD*QL*SLNSF FVMIYL*VYIFKLFNFLNLVIKKRAFYI*

Frame 1

LEGQSISKSSSEQPRWWRRRVVAVAPSVRSGAG EEGAAAGEEEGSPRAEGLRDPPAARRRE*RRGC CASGASSPARARRASPSAPRTARAHTKPPPAPHR PAAAARAREGFGRRAGDTPAPPPRCSRKAHRLP GPPGTPRSRLGRAGGGRGEDHVSGLRSLSAAQD QSCLCCRRHVVYIKFVIVGGHFGI*IMGCVQCKD KEATKLTEERDGSLNQSSGYRYGTDPTPQHYPS FGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTG TLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEK FQILNSSEGDWWEARSLTTGETGYIPSNYVAPV DSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFL IRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKL DNGGYYITTRAQFETLQQLVQHYSEKADGLCFN LTVIASSCTPQTSGLAKDAWEVARRSLCLEKKL GQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESF LEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEY MNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG MAYIERMNYIHRDLRSANILVGNGLICKIADFGL ARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT IKSDVWSFGILLTELVTKGRVPYPGMNNREVLE QVERGYRMPCPQDCPISLHELMIHCWKKDPEERP TFEYLQSFLEDYFTATEPQYQPGENL*GPGLRR EALSQRLPHPSPLAFNSVASCSPAAEPPRIRLH VTLKLTNFHGPH**HLSPNPNLLCEAFETEPCYF SDFGKCIVSMLCKRPNLCSV*IVTPVPTILVLS FFKNANPM*F*LCLHLIQLKKKKYYFPKVASLS KTIKFFFMF*QKPIRTGVCFCFLFYKYEYI*YIC PCTYTMWVLMWRLWPA*ATKLRDPEGGFYCKSA SKHRCYSENTSGLIFGFCKA*IFSFGLHFPGS* LYL*VVVTLTLFRNHPPS*IYKFC*HYLLQLTAI CSQNLKISKQMADTTKRTGRWIPHKLLV*KYEC *NVSDIFNLINL*PHLSDLKPIAL*SWQPAKLS HATKISGGNEGGGCTFPIVK*VF*MSCTANE*LS ICPGVLQWNNYALLYISWGCTKTKKYYIFSCCL YQP*ITYV*QQQIKNPISIEFLILTSNSEVLIP FLL*FICEFTFLNCLTFLI**LKREHFTFE

Frame 2

WRGRASARVAASSRAGGGGASLQLRHLSGAEPA RRGLPRARRRGRREPKAFETRPPPGGESRGEVV VRAARPLPPGRAALLPAHRGPPGRTQSRRPRRT ARRPPPAPGRDSAAGPGTPRRRPLGALGRPTGSR ARRGPPGAASAAPEEGGERTM*VGSGASAPRRT SPASVVEDMWCI*SL*SLADILEFR*WAVCNVR IKKQQN*RRRGTAA*TRALGTAMAQTPPLSTTPA SV*PPSPTTTTSTQPGAKDSPSLEV*TLRLIRG PCVREEEQE*HSLWPFMTMKHGQKMT*VFTKEK NFKY*TARKEIGGKPAP*QLERQVTFPAIMWLQL TLSRQKSGTLENLAEKMLSDSYCPLETQEVPFL SARVKPPKVPIHFLSVIGMI*KETMSNIIKFAN LTMVDTTLPPGPSLKHFSSLYNITQRKLMVCVLT *L*LHRVVPHKLLDWLKMLGKLHVVRCVWRRSW VRGVSLKCGLVPGMETQK*P*RLLNQAQCPPNH SLRKRRS*RS*STTSWSSSMQWCLRSPSTSSPSI *TKEVYWIS*KMEKEEL*NYQILWTWQHRWLQE WLTSSA*IISIEICDQQTF*WGMDSYARLLTSD WPD**KTMSTQQDKVQSSPSSGRPPRQPCTGGSQ SSLTCGLLESYSQSWSPKEECHTQA*TTGRCWS RWSEATGCPARRTAPSLCMSS*STAGKRTLKNA PLLSTCRASWKTTLPRQSPSTNLVKTCKARVCGE RPCPRGCPTPPH*LSIP*PAAPQQRNRPGSDCM *L*S*RTSMALINDTCPQIRTSSVKHSRQNLVI SQTLENALYRCYVKGQTSVQCK*LLQCQQS*CFP FLKMQILCDFNSVFT*FN*KKKSIIFQKWPLCL KQ*NFFSCFNKNQSGQVFVFVFFFINMNIYNIY VPVHIQCGC*CGDCGRPEPPSCGTQREDFTASQH QSTGVILKTPVASFLAFAKHEFFHLDCTFLVHD CTCRWLLL*LFSGTTPQAEFTSSVSTICFNLLR FVLKT*K*ASKWLILPRELEDGYHTNFLYKNMNA EMFQTFLI**TCNHI*VI*NP*HCSHGNPLNFL MQLKFLGEMRVGVVHFPL*NKCFKCPVLLTNDF LYVQEFSSGITMHYFTFHGDAQKQKSITFLVAVC TNLKLHMFNNNKSKILFLLSF*Y*LATLKS*FL FCYDLFVSLHF*IV*LS*FSN*KESILHL

Sequence FYN.gAug05

CATGTCGTTGACTGCAGGCTGGTGGAAGGTTCTGCAGATACTCAGTGGATGTCAGAGCCGCAGCGCCACATCCATGGCCTCCCCGATGTTAATGGGAAGA GGTACACACTCCATTCCTGCTCTTCATCACAGGGAAGGAGATTGGTGGGAAGCCCGCTCCTTGACAACTGGAGAGACAGGTTACATTCCCAGCAATTATG TGGCTCCAGTTGACTCTATCCAGGCAGAAGAGTGGTACTTTGGAAAACTTGGCCGAAAAGATGCTGAGCGACAGCTATTGTCCTTTGGAAACCCAAGAGG TACCTTTCTTATCCGCGAGAGTGAAACCACCAAAGGTGCCTATTCACTTTCTATCCGTGATTGGGATGATATGAAAGGAGACCATGTCAAACATTATAAA ATTCGCAAACTTGACAATGGTGGATACTACATTACCACCCGGGCCCAGTTTGAAACACTTCAGCAGCTTGTACAACATTACTCAGAGAGAGCTGCAGGTC TCTGCTGCCGCCTAGTAGTTCCCTGTCACAAAGGGATGCCAAGGCTTACCGATCTGTCTGTCAAAACCAAAGATGTCTGGGAAATCCCTCGAGAATCCCT GCAGTTGATCAAGAGACTGGGAAATGGGCAGTTTGGGGAAGTATGGATGGGTACCTGGAATGGAAACACAAAAGTAGCCATAAAGACTCTTAAACCAGGC ACAATGTCCCCCGAATCATTCCTTGAGGAAGCGCAGATCATGAAGAAGCTGAAGCACGACAAGCTGGTCCAGCTCTATGCAGTGGTGTCTGAGGAGCCCA TCTACATCGTCACCGAGTATATGAACAAAGGTTGGGCAACACCTCTCCTGTCTCCAGCTCACAGTGCCTTAAGGGGTTGTTTAGGGGAGAGAAATGGAAG TTTCCTACTTGCTACTTTTCTAGTTTCTGCCTGGGTCAAGTATTCCCATTAGGAACCACCAGTTATGTGCTCGTTAATGAAAACATTTTTTAAAACAGAC TAACCTTGCGTTTACCCCACCCCAAATCCTTATGAAATGCCAAATACTTTTTACATGTTATGTGTGTCAGAAATTCAAGCTCCTCTCC

FYN-F1 (forward primer)
FYN-R1 (reverse primer)
Mutually exclusive exon skipping

Frame 0

HVVDCRLVEGSADTQWMSEPQRHIHGLPDVNGK RYTLHSCSSSQGRRLVGSPLLDNWRDRLHSQQLC GSS*LYPGRRVVLWKTWPKRC*ATAIVLWKPKR YLSYPRE*NHQRCLFTFYP*LG*YERRPCQTL* NSQT*QWWILHYHPGPV*NTSAACTTLLRESCRS LLPPSSSLSQRDAKAYRSVCQNQRCLGNPSRIP AVDQETGKWAVWGSMDGYLEWKHKSSHKDS*TR HNVPRIIP*GSADHEEAEARQAGPALCSGV*GAH LHRHRVYEQRLGNTSPVSSSQCLKGLFRGEKWK FPTCYFSSFCLGQVFPLGTTSYVLVNENIF*NR LTLRLPHPKSL*NAKYFLHVMCVRNSSSS

Frame 1

MSLTAGWWKVLQILSGCQSRSATSMASPMLMGR GTHSIPALHHREGDWWEARSLTTGETGYIPSNY VAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRG TFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK IRKLDNGGYYITTRAQFETLQQLVQHYSERAAG LCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESL QLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPG TMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEP IYIVTEYMNKGWATPLLSPAHSALRGCLGERNGS FLLATFLVSAWVKYSH*EPPVMCSLMKTFFKTD *PCVYPTPNPYEMPNTFYMLCVSEIQAPL

Frame 2

CR*LQAGGRFCRYSVDVRAAAPHPWPPRC*WEE VHTPFLLFITGKEIGGKPAP*QLERQVTFPAIM WLQLTLSRQKSGTLENLAEKMLSDSYCPLETQE VPFLSARVKPPKVPIHFLSVIGMI*KETMSNIIK FANLTMVDTTLPPGPSLKHFSSLYNITQRELQV SAAA**FPVTKGCQGLPICLSKPKMSGKSLENP CS*SRDWEMGSLGKYGWVPGMETQK*P*RLLNQA QCPPNHSLRKRRS*RS*STTSWSSSMQWCLRSP STSSPSI*TKVGQHLSCLQLTVP*GVV*GREME VSYLLLF*FLPGSSIPIRNHQLCAR**KHFLKQT NLAFTPPQILMKCQILFTCYVCQKFKLLS

Sequence FYN.eAug05

ATTTCCCCTTGTGTAATAATCTCCCTTCTTGTGAATTTCGTTTCGGCAGGAGTGACACTCTTTGTGGCCCTTTATGACTATGAAGCACGGACAGAAGATG ACCTGAGTTTTCACAAAGGAGAAAAATTTCAAATATTGAACAGCTCGGAAGGAGATTGGTGGGAAGCCCGCTCCTTGACAACTGGAGAGACAGGTTACAT TCCCAGCAATTATGTGGCTCCAGTTGACTCTATCCAGGCAGAAGAGTGGTACTTTGGAAAACTTGGCCGAAAAGATGCTGAGCGACAGCTATTGTCCTTT GGAAACCCAAGAGGTACCTTTCTTATCCGCGAGAGTGAAACCACCAAAGGTGCCTATTCACTTTCTATCCGTGATTGGGATGATATGAAAGGAGACCATG TCAAACATTATAAAATTCGCAAACTTGACAATGGTGGATACTACATTACCACCCGGGCCCAGTTTGAAACACTTCAGCAGCTTGTACAACATTACTCAGA GAGAGCTGCAGGTCTCTGCTGCCGCCTAGTAGTTCCCTGTCACAAAGGGATGCCAAGGCTTACCGATCTGTCTGTCAAAACCAAAGATGTCTGGGAAATC CCTCGAGAATCCCTGCAGTTGATCAAGAGACTGGGAAATGGGCAGTTTGGGGAAGTATGGATGGGTACCTGGAATGGAAACACAAAAGTAGCCATAAAGA CTCTTAAACCAGGCACAATGTCCCCCGAATCATTCCTTGAGGAAGCGCAGATCATGAAGAAGCTGAAGCACGACAAGCTGGTCCAGCTCTATGCAGTGGT GTCTGAGGAGCCCATCTACATCGTCACCGAGTATATGAACAAAGGTTGGGCAACACCTCTCCTGTCTCCAGCTCACAGTGCCTTAAGGGGTTGTTTAGGG GAGAGAAATGGAAGTTTCCTACTTGCTACTTTTCTAGTTTCTGCCTGGGTCAAGTATTCCCATTAGGAACCACCAGTTATGTGCTCGTTAATGAAAACAT TTTTTAAAACAGACTAACCTTGCGTTTACCCCACCCCAAATCCTTATGAAATGCCAAATACTTTTTACATGTTATGTGTGTCAGAAATTCAAGCTCCTCT CC

FYN-F1 (forward primer)
FYN-R1 (reverse primer)
Mutually exclusive exon skipping

Frame 0

ISPCVIISLLVNFVSAGVTLFVALYDYEARTED DLSFHKGEKFQILNSSEGDWWEARSLTTGETGYI PSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSF GNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH VKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSE RAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEI PRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIK TLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVV SEEPIYIVTEYMNKGWATPLLSPAHSALRGCLG ERNGSFLLATFLVSAWVKYSH*EPPVMCSLMKT FFKTD*PCVYPTPNPYEMPNTFYMLCVSEIQAPL

Frame 1

FPLV**SPFL*ISFRQE*HSLWPFMTMKHGQKM T*VFTKEKNFKY*TARKEIGGKPAP*QLERQVT FPAIMWLQLTLSRQKSGTLENLAEKMLSDSYCPL ETQEVPFLSARVKPPKVPIHFLSVIGMI*KETM SNIIKFANLTMVDTTLPPGPSLKHFSSLYNITQ RELQVSAAA**FPVTKGCQGLPICLSKPKMSGKS LENPCS*SRDWEMGSLGKYGWVPGMETQK*P*R LLNQAQCPPNHSLRKRRS*RS*STTSWSSSMQW CLRSPSTSSPSI*TKVGQHLSCLQLTVP*GVV*G REMEVSYLLLF*FLPGSSIPIRNHQLCAR**KH FLKQTNLAFTPPQILMKCQILFTCYVCQKFKLL S

Frame 2

FPLCNNLPSCEFRFGRSDTLCGPL*L*STDRR* PEFSQRRKISNIEQLGRRLVGSPLLDNWRDRLH SQQLCGSS*LYPGRRVVLWKTWPKRC*ATAIVL WKPKRYLSYPRE*NHQRCLFTFYP*LG*YERRPC QTL*NSQT*QWWILHYHPGPV*NTSAACTTLLR ESCRSLLPPSSSLSQRDAKAYRSVCQNQRCLGN PSRIPAVDQETGKWAVWGSMDGYLEWKHKSSHKD S*TRHNVPRIIP*GSADHEEAEARQAGPALCSG V*GAHLHRHRVYEQRLGNTSPVSSSQCLKGLFR GEKWKFPTCYFSSFCLGQVFPLGTTSYVLVNENI F*NRLTLRLPHPKSL*NAKYFLHVMCVRNSSSS

Sequence FYN.aAug05

GCTGGAGGGGCAGAGCATCAGCAAGAGTAGCAGCGAGCAGCCGCGCTGGTGGCGGCGGCGCGTCGTTGCAGTTGCGCCATCTGTCAGGAGCGGAGCCGGC GAGGAGGGGGCTGCCGCGGGCGAGGAGGAGGGGTCGCCGCGAGCCGAAGGCCTTCGAGACCCGCCCGCCGCCCGGCGGCGAGAGTAGAGGCGAGGTTGTT GTGCGAGCGGCGCGTCCTCTCCCGCCCGGGCGCGCCGCGCTTCTCCCAGCGCACCGAGGACCGCCCGGGCGCACACAAAGCCGCCGCCCGCGCCGCACCG CCCGGCGGCCGCCGCCCGCGCCAGGGAGGGATTCGGCCGCCGGGCCGGGGACACCCCGGCGCCGCCCCCTCGGTGCTCTCGGAAGGCCCACCGGCTCCCG GGCCCGCCGGGGACCCCCCGGAGCCGCCTCGGCCGCGCCGGAGGAGGGCGGGGAGAGGACCATGTGAGTGGGCTCCGGAGCCTCAGCGCCGCGCAGTTTT TTTGAAGAAGCAGGATGCTGATCTAAACGTGGAAAAAGACCAGTCCTGCCTCTGTTGTAGAAGACATGTGGTGTATATAAAGTTTGTGATCGTTGGCGGA CATTTTGGAATTTAGATAATGGGCTGTGTGCAATGTAAGGATAAAGAAGCAACAAAACTGACGGAGGAGAGGGACGGCAGCCTGAACCAGAGCTCTGGGT ACCGCTATGGCACAGACCCCACCCCTCAGCACTACCCCAGCTTCGGTGTGACCTCCATCCCCAACTACAACAACTTCCACGCAGCCGGGGGCCAAGGACT CACCGTCTTTGGAGGTGTGAACTCTTCGTCTCATACGGGGACCTTGCGTACGAGAGGAGGAACAGGAGTGACACTCTTTGTGGCCCTTTATGACTATGAA GCACGGACAGAAGATGACCTGAGTTTTCACAAAGGAGAAAAATTTCAAATATTGAACAGCTCGGAAGGAGATTGGTGGGAAGCCCGCTCCTTGACAACTG GAGAGACAGGTTACATTCCCAGCAATTATGTGGCTCCAGTTGACTCTATCCAGGCAGAAGAGTGGTACTTTGGAAAACTTGGCCGAAAAGATGCTGAGCG ACAGCTATTGTCCTTTGGAAACCCAAGAGGTACCTTTCTTATCCGCGAGAGTGAAACCACCAAAGGTGCCTATTCACTTTCTATCCGTGATTGGGATGAT ATGAAAGGAGACCATGTCAAACATTATAAAATTCGCAAACTTGACAATGGTGGATACTACATTACCACCCGGGCCCAGTTTGAAACACTTCAGCAGCTTG TACAACATTACTCAGAGAGAGCTGCAGGTCTCTGCTGCCGCCTAGTAGTTCCCTGTCACAAAGGGATGCCAAGGCTTACCGATCTGTCTGTCAAAACCAA AGATGTCTGGGAAATCCCTCGAGAATCCCTGCAGTTGATCAAGAGACTGGGAAATGGGCAGTTTGGGGAAGTATGGATGGGTACCTGGAATGGAAACACA AAAGTAGCCATAAAGACTCTTAAACCAGGCACAATGTCCCCCGAATCATTCCTTGAGGAAGCGCAGATCATGAAGAAGCTGAAGCACGACAAGCTGGTCC AGCTCTATGCAGTGGTGTCTGAGGAGCCCATCTACATCGTCACCGAGTATATGAACAAAGGAAGTTTACTGGATTTCTTAAAAGATGGAGAAGGAAGAGC TCTGAAATTACCAAATCTTGTGGACATGGCAGCACAGGTGGCTGCAGGAATGGCTTACATCGAGCGCATGAATTATATCCATAGAGATCTGCGATCAGCA AACATTCTAGTGGGGAATGGACTCATATGCAAGATTGCTGACTTCGGATTGGCCCGATTGATAGAAGACAATGAGTACACAGCAAGACAAGGTGCAAAGT TCCCCATCAAGTGGACGGCCCCCGAGGCAGCCCTGTACGGGAGGTTCACAATCAAGTCTGACGTGTGGTCTTTTGGAATCTTACTCACAGAGCTGGTCAC CAAAGGAAGAGTGCCATACCCAGGCATGAACAACCGGGAGGTGCTGGAGCAGGTGGAGCGAGGCTACAGGATGCCCTGCCCGCAGGACTGCCCCATCTCT CTGCATGAGCTCATGATCCACTGCTGGAAAAAGGACCCTGAAGAACGCCCCACTTTTGAGTACTTGCAGAGCTTCCTGGAAGACTACTTTACCGCGACAG AGCCCCAGTACCAACCTGGTGAAAACCTGTAAGGCCCGGGTCTGCGGAGAGAGGCCTTGTCCCAGAGGCTGCCCCACCCCTCCCCATTAGCTTTCAATTC CGTAGCCAGCTGCTCCCCAGCAGCGGAACCGCCCAGGATCAGATTGCATGTGACTCTGAAGCTGACGAACTTCCATGGCCCTCATTAATGACACTTGTCC CCAAATCCGAACCTCCTCTGTGAAGCATTCGAGACAGAACCTTGTTATTTCTCAGACTTTGGAAAATGCATTGTATCGATGTTATGTAAAAGGCCAAACC TCTGTTCAGTGTAAATAGTTACTCCAGTGCCAACAATCCTAGTGCTTTCCTTTTTTAAAAATGCAAATCCTATGTGATTTTAACTCTGTCTTCACCTGAT TCAACTAAAAAAAAAAAAGTATTATTTTCCAAAAGTGGCCTCTTTGTCTAAAACAATAAAATTTTTTTTCATGTTTTAACAAAAACCAATCAGGACAGGT GTTTGTTTTTGTTTTCTTTTTTATAAATATGAATATATATAATATATATGTCCCTGTACATATACAATGTGGGTGCTAATGTGGAGACTGTGGCCGGCCT GAGCCACCAAGCTGCGGGACCCAGAGGGAGGATTTTACTGCAAGTCAGCATCAAAGCACCGGTGTTATTCTGAAAACACCAGTGGCCTCATTTTTGGCTT TTGCAAAGCATGAATTTTTTCATTTGGATTGCACTTTCCTGGTTCATGACTGTACCTGTAGGTGGTTGTTACTTTGACTCTTTTCAGGAACCACCCCCCA AGCTGAATTTACAAGTTCTGTTAGCACTATTTGCTTCAACTTACTGCGATTTGTTCTCAAAACTTAAAAATAAGCAAGCAAATGGCTGATACTACCAAGA GAACTGGAAGATGGATACCACACAAACTTCTTGTATAAAAATATGAATGCTGAAATGTTTCAGACATTTTTAATTTAATAAACCTGTAACCACATTTAAG TGATCTAAAACCCATAGCATTGTAGTCATGGCAACCCGCTAAACTTTCTCATGCAACTAAAATTTCTGGGGGAAATGAGGGTGGGGGTTGTACATTTCCC ATTGTAAAATAAGTGTTTTAAATGTCCTGTACTGCTAACGAATGACTTTCTATATGTCCAGGAGTTCTCCAGTGGAATAACTATGCACTACTTTACATTT CATGGGGATGCACAAAAACAAAAAAGTATTACATTTTTAGTTGCTGTTTGTACCAACCTTAAATTACATATGTTTAACAACAACAAATCAAAAATCCTAT TTCTATTGAGTTTTTAATACTGACTAGCAACTCTGAAGTCTTAATTCCTTTTTTGTTATGATTTATTTGTGAGTTTACATTTTTAAATTGTTTAACTTTC TTAATTTAGTAATTAAAAAGAGAGCATTTTACATTTGAA

FYN-F1 (forward primer)
FYN-R1 (reverse primer)
Mutually exclusive exon skipping

Frame 0

AGGAEHQQE*QRAAALVAAARRCSCAICQERSR RGGGCRGRGGGVAASRRPSRPARRPAARVEARLL CERRVLSRPGAPRFSQRTEDRPGAHKAAARAAP PGGRRPRQGGIRPPGRGHPGAAPSVLSEGPPAP GPAGDPPEPPRPRRRRAGRGPCEWAPEPQRRAVF LKKQDADLNVEKDQSCLCCRRHVVYIKFVIVGG HFGI*IMGCVQCKDKEATKLTEERDGSLNQSSG YRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGL TVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYE ARTEDDLSFHKGEKFQILNSSEGDWWEARSLTT GETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAER QLLSFGNPRGTFLIRESETTKGAYSLSIRDWDD MKGDHVKHYKIRKLDNGGYYITTRAQFETLQQL VQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTK DVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNT KVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLV QLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRA LKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSA NILVGNGLICKIADFGLARLIEDNEYTARQGAK FPIKWTAPEAALYGRFTIKSDVWSFGILLTELVT KGRVPYPGMNNREVLEQVERGYRMPCPQDCPIS LHELMIHCWKKDPEERPTFEYLQSFLEDYFTAT EPQYQPGENL*GPGLRREALSQRLPHPSPLAFNS VASCSPAAEPPRIRLHVTLKLTNFHGPH**HLS PNPNLLCEAFETEPCYFSDFGKCIVSMLCKRPN LCSV*IVTPVPTILVLSFFKNANPM*F*LCLHLI QLKKKKYYFPKVASLSKTIKFFFMF*QKPIRTG VCFCFLFYKYEYI*YICPCTYTMWVLMWRLWPA *ATKLRDPEGGFYCKSASKHRCYSENTSGLIFGF CKA*IFSFGLHFPGS*LYL*VVVTLTLFRNHPP S*IYKFC*HYLLQLTAICSQNLKISKQMADTTK RTGRWIPHKLLV*KYEC*NVSDIFNLINL*PHLS DLKPIAL*SWQPAKLSHATKISGGNEGGGCTFP IVK*VF*MSCTANE*LSICPGVLQWNNYALLYI SWGCTKTKKYYIFSCCLYQP*ITYV*QQQIKNPI SIEFLILTSNSEVLIPFLL*FICEFTFLNCLTF LI**LKREHFTFE

Frame 1

LEGQSISKSSSEQPRWWRRRVVAVAPSVRSGAG EEGAAAGEEEGSPRAEGLRDPPAARRRE*RRGC CASGASSPARARRASPSAPRTARAHTKPPPAPHR PAAAARAREGFGRRAGDTPAPPPRCSRKAHRLP GPPGTPRSRLGRAGGGRGEDHVSGLRSLSAAQF F*RSRMLI*TWKKTSPASVVEDMWCI*SL*SLAD ILEFR*WAVCNVRIKKQQN*RRRGTAA*TRALG TAMAQTPPLSTTPASV*PPSPTTTTSTQPGAKD SPSLEV*TLRLIRGPCVREEEQE*HSLWPFMTMK HGQKMT*VFTKEKNFKY*TARKEIGGKPAP*QL ERQVTFPAIMWLQLTLSRQKSGTLENLAEKMLS DSYCPLETQEVPFLSARVKPPKVPIHFLSVIGMI *KETMSNIIKFANLTMVDTTLPPGPSLKHFSSL YNITQRELQVSAAA**FPVTKGCQGLPICLSKP KMSGKSLENPCS*SRDWEMGSLGKYGWVPGMETQ K*P*RLLNQAQCPPNHSLRKRRS*RS*STTSWS SSMQWCLRSPSTSSPSI*TKEVYWIS*KMEKEE L*NYQILWTWQHRWLQEWLTSSA*IISIEICDQQ TF*WGMDSYARLLTSDWPD**KTMSTQQDKVQS SPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWS PKEECHTQA*TTGRCWSRWSEATGCPARRTAPSL CMSS*STAGKRTLKNAPLLSTCRASWKTTLPRQ SPSTNLVKTCKARVCGERPCPRGCPTPPH*LSI P*PAAPQQRNRPGSDCM*L*S*RTSMALINDTCP QIRTSSVKHSRQNLVISQTLENALYRCYVKGQT SVQCK*LLQCQQS*CFPFLKMQILCDFNSVFT* FN*KKKSIIFQKWPLCLKQ*NFFSCFNKNQSGQV FVFVFFFINMNIYNIYVPVHIQCGC*CGDCGRP EPPSCGTQREDFTASQHQSTGVILKTPVASFLA FAKHEFFHLDCTFLVHDCTCRWLLL*LFSGTTPQ AEFTSSVSTICFNLLRFVLKT*K*ASKWLILPR ELEDGYHTNFLYKNMNAEMFQTFLI**TCNHI* VI*NP*HCSHGNPLNFLMQLKFLGEMRVGVVHFP L*NKCFKCPVLLTNDFLYVQEFSSGITMHYFTF HGDAQKQKSITFLVAVCTNLKLHMFNNNKSKIL FLLSF*Y*LATLKS*FLFCYDLFVSLHF*IV*LS *FSN*KESILHL

Frame 2

WRGRASARVAASSRAGGGGASLQLRHLSGAEPA RRGLPRARRRGRREPKAFETRPPPGGESRGEVV VRAARPLPPGRAALLPAHRGPPGRTQSRRPRRT ARRPPPAPGRDSAAGPGTPRRRPLGALGRPTGSR ARRGPPGAASAAPEEGGERTM*VGSGASAPRSF FEEAGC*SKRGKRPVLPLL*KTCGVYKVCDRWR TFWNLDNGLCAM*G*RSNKTDGGEGRQPEPELWV PLWHRPHPSALPQLRCDLHPQLQQLPRSRGPRT HRLWRCELFVSYGDLAYERRNRSDTLCGPL*L* STDRR*PEFSQRRKISNIEQLGRRLVGSPLLDNW RDRLHSQQLCGSS*LYPGRRVVLWKTWPKRC*A TAIVLWKPKRYLSYPRE*NHQRCLFTFYP*LG* YERRPCQTL*NSQT*QWWILHYHPGPV*NTSAAC TTLLRESCRSLLPPSSSLSQRDAKAYRSVCQNQ RCLGNPSRIPAVDQETGKWAVWGSMDGYLEWKH KSSHKDS*TRHNVPRIIP*GSADHEEAEARQAGP ALCSGV*GAHLHRHRVYEQRKFTGFLKRWRRKS SEITKSCGHGSTGGCRNGLHRAHELYP*RSAIS KHSSGEWTHMQDC*LRIGPIDRRQ*VHSKTRCKV PHQVDGPRGSPVREVHNQV*RVVFWNLTHRAGH QRKSAIPRHEQPGGAGAGGARLQDALPAGLPHL SA*AHDPLLEKGP*RTPHF*VLAELPGRLLYRDR APVPTW*KPVRPGSAERGLVPEAAPPLPISFQF RSQLLPSSGTAQDQIACDSEADELPWPSLMTLV PKSEPPL*SIRDRTLLFLRLWKMHCIDVM*KAKP LFSVNSYSSANNPSAFLF*KCKSYVILTLSSPD STKKKKVLFSKSGLFV*NNKIFFHVLTKTNQDR CLFLFSFL*I*IYIIYMSLYIYNVGANVETVAGL SHQAAGPRGRILLQVSIKAPVLF*KHQWPHFWL LQSMNFFIWIALSWFMTVPVGGCYFDSFQEPPP KLNLQVLLALFASTYCDLFSKLKNKQANG*YYQE NWKMDTTQTSCIKI*MLKCFRHF*FNKPVTTFK *SKTHSIVVMATR*TFSCN*NFWGK*GWGLYIS HCKISVLNVLYC*RMTFYMSRSSPVE*LCTTLHF MGMHKNKKVLHF*LLFVPTLNYICLTTTNQKSY FY*VFNTD*QL*SLNSFFVMIYL*VYIFKLFNF LNLVIKKRAFYI*