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Sequences

Sequence BCL2L1.hAug05

GGCTGCGCTGGGGCGGACCGCCGGGGGCGAGGCCCCTCCTCTCAGGAAGGTCTAGGGGGCGCCCCCGGGGGAGGGCGGTTGCCTAGCAACGGGGCGGTGG
CTCGGCGGGTACCCGGCCTAGTGAGCTCGAGAAGCCGCTAGGCCGCAGCCGGCCCACCCTGGGCTCCGGAGAGGTGCAGCCCCCGGCCCCGGAGCCCTCC
CGGGGGCGCCAGAAAGCCACTTTGGGCCTGTCCCCAGGAAAACGTGGTCTCAGCTGTGGGGCCGTCGAGCAGGCCTCGACCCCTCTTCCTGACCTGAGGA
GAGGCCCAGCGCCTCACCCTCACCCAGTCTTTGTGCAGGGCGCCGGCGGCCATTGTGTCCGGGCGGGGAATGGAGGACCCGGCAATCCCCAACTGCCACG
TTCTGGGCCTTTGGGGAATTCAGAGCAAACCAGCGGCATTTGTTGGGGGTCTCCGGCCTTCAACATCACAGACAGGCCTGGGGGTGGCCTTCCCAAAGTC
AGATTGCAGATCTGAGGCAGTTTCCCCCTCCCTGCGTCCCTCACTGAAACCTTGAACCCCATTGAGAAGTCCCTTTAGGGTTTCGGACGCCTCCACCTCA
CCCTGGGCTGGTGCTTAAATAGAAAAAAGAAAAACAAAAACCAACTAAATCCATACCAGCCACCTCCGGGAGAGTACTCCTGGCTCCCAGTAGGAGGCGG
AGAGCCAAGGGGCGTGCAAGAGAGAGGGGGCTGGGCTCCCGGGTGGCAGGAGGCCGCGGCTGCGGAGCGGCCGCCCTCGATCCGGGCGATGGAGGAGGAA
GCAAGCGAGGGGGCTGGTTCCTGAGCTTCGCAATTCCTGTGTCGCCTTCTGGGCTCCCAGCCTGCCGGGTCGCATGATCCCTCCGGCCGGAGCTGGTTTT
TTTGCCAGCCACCGCGAGGCCGGCTGAGTTACCGGCATCCCCGCAGCCACCTCCTCTCCCGACCTGTGATACAAAAGATCTTCCGGGGGCTGCACCTGCC
TGCCTTTGCCTAAGGCGGATTTGAATCTCTTTCTCTCCCTTCAGAATCTTATCTTGGCTTTGGATCTTAGAAGAGAATCACTAACCAGAGACGAGACTCA
GTGAGTGAGCAGGTGTTTTGGACAATGGACTGGTTGAGCCCATCCCTATTATAAAAATGTCTCAGAGCAACCGGGAGCTGGTGGTTGACTTTCTCTCCTA
CAAGCTTTCCCAGAAAGGATACAGCTGGAGTCAGTTTAGTGATGTGGAAGAGAACAGGACTGAGGCCCCAGAAGGGACTGAATCGGAGATGGAGACCCCC
AGTGCCATCAATGGCAACCCATCCTGGCACCTGGCAGACAGCCCCGCGGTGAATGGAGCCACTGGCCACAGCAGCAGTTTGGATGCCCGGGAGGTGATCC
CCATGGCAGCAGTAAAGCAAGCGCTGAGGGAGGCAGGCGACGAGTTTGAACTGCGGTACCGGCGGGCATTCAGTGACCTGACATCCCAGCTCCACATCAC
CCCAGGGACAGCATATCAGAGCTTTGAACAGGATACTTTTGTGGAACTCTATGGGAACAATGCAGCAGCCGAGAGCCGAAAGGGCCAGGAACGCTTCAAC
CGCTGGTTCCTGACGGGCATGACTGTGGCCGGCGTGGTTCTGCTGGGCTCACTCTTCAGTCGGAAATGACCAGACACTGACCATCCACTCTACCCTCCCA
CCCCCTTCTCTGCTCCACCACATCCTCCGTCCAGCCGCCATTGCCACCAGGAGAACCACTACATGCAGCCCATGCCCACCTGCCCATCACAGGGTTGGGC
CCAGATCTGGTCCCTTGCAGCTAGTTTTCTAGAATTTATCACACTTCTGTGAGACCCCCACACCTCAGTTCCCTTGGCCTCAGAATTCACAAAATTTCCA
CAAAATCTGTCCAAAGGAGGCTGGCAGGTATGGAAGGGTTTGTGGCTGGGGGCAGGAGGGCCCTACCTGATTGGTGCAACCCTTACCCCTTAGCCTCCCT
GAAAATGTTTTTCTGCCAGGGAGCTTGAAAGTTTTCAGAACCTCTTCCCCAGAAAGGAGACTAGATTGCCTTTGTTTTGATGTTTGTGGCCTCAGAATTG
ATCATTTTCCCCCCACTCTCCCCACACTAACCTGGGTTCCCTTTCCTTCCATCCCTACCCCCTAAGAGCCATTTAGGGGCCACTTTTGACTAGGGATTCA
GGCTGCTTGGGATAAAGATGCAAGGACCAGGACTCCCTCCTCACCTCTGGACTGGCTAGAGTCCTCACTCCCAGTCCAAATGTCCTCCAGAAGCCTCTGG
CTAGAGGCCAGCCCCACCCAGGAGGGAGGGGGCTATAGCTACAGGAAGCACCCCATGCCAAAGCTAGGGTGGCCCTTGCAGTTCAGCACCACCCTAGTCC
CTTCCCCTCCCTGGCTCCCATGACCATACTGAGGGACCAACTGGGCCCAAGACAGATGCCCCAGAGCTGTTTATGGCCTCAGCTGCCTCACTTCCTACAA
GAGCAGCCTGTGGCATCTTTGCCTTGGGCTGCTCCTCATGGTGGGTTCAGGGGACTCAGCCCTGAGGTGAAAGGGAGCTATCAGGAACAGCTATGGGAGC
CCCAGGGTCTTCCCTACCTCAGGCAGGAAGGGCAGGAAGGAGAGCCTGCTGCATGGGGTGGGGTAGGGCTGACTAGAAGGGCCAGTCCTGCCTGGCCAGG
CAGATCTGTGCCCCATGCCTGTCCAGCCTGGGCAGCCAGGCTGCCAAGGCCAGAGTGGCCTGGCCAGGAGCTCTTCAGGCCTCCCTCTCTCTTCTGCTCC
ACCCTTGGCCTGTCTCATCCCCAGGGGTCCCAGCCACCCCGGGCTCTCTGCTGTACATATTTGAGACTAGTTTTTATTCCTTGTGAAGATGATATACTAT
TTTTGTTAAGCGTGTCTGTATTTATGTGTGAGGAGCTGCTGGCTTGCAGTGCGCGTGCACGTGGAGAGCTGGTGCCCGGAGATTGGACGGCCTGATGCTC
CCTCCCCTGCCCTGGTCCAGGGAAGCTGGCCGAGGGTCCTGGCTCCTGAGGGGCATCTGCCCCTCCCCCAACCCCCACCCCACACTTGTTCCAGCTCTTT
GAAATAGTCTGTGTGAAGGTGAAAGTGCAGTTCAGTAATAAACTGTGTTTACTCAGTGAACAAAGAGCC
  • BCLX-3 (forward primer)
  • BCLX-2 (reverse primer)
  • Alternative donor

Frame 0

GCAGADRRGRGPSSQEGLGGAPGGGRLPSNGAV
ARRVPGLVSSRSR*AAAGPPWAPERCSPRPRSPP
GGARKPLWACPQENVVSAVGPSSRPRPLFLT*G
EAQRLTLTQSLCRAPAAIVSGRGMEDPAIPNCH
VLGLWGIQSKPAAFVGGLRPSTSQTGLGVAFPKS
DCRSEAVSPSLRPSLKP*TPLRSPFRVSDASTS
PWAGA*IEKRKTKTN*IHTSHLRESTPGSQ*EA
ESQGACKREGAGLPGGRRPRLRSGRPRSGRWRRK
QARGLVPELRNSCVAFWAPSLPGRMIPPAGAGF
FASHREAG*VTGIPAATSSPDL*YKRSSGGCTC
LPLPKADLNLFLSLQNLILALDLRRESLTRDETQ
*VSRCFGQWTG*AHPYYKNVSEQPGAGG*LSLL
QAFPERIQLESV**CGREQD*GPRRD*IGDGDP
QCHQWQPILAPGRQPRGEWSHWPQQQFGCPGGDP
HGSSKASAEGGRRRV*TAVPAGIQ*PDIPAPHH
PRDSISEL*TGYFCGTLWEQCSSREPKGPGTLQ
PLVPDGHDCGRRGSAGLTLQSEMTRH*PSTLPSH
PLLCSTTSSVQPPLPPGEPLHAAHAHLPITGLG
PDLVPCS*FSRIYHTSVRPPHLSSLGLRIHKIS
TKSVQRRLAGMEGFVAGGRRALPDWCNPYPLASL
KMFFCQGA*KFSEPLPQKGD*IAFVLMFVASEL
IIFPPLSPH*PGFPFLPSLPPKSHLGATFD*GF
RLLGIKMQGPGLPPHLWTG*SPHSQSKCPPEASG
*RPAPPRREGAIATGSTPCQS*GGPCSSAPP*S
LPLPGSHDHTEGPTGPKTDAPELFMASAASLPT
RAACGIFALGCSSWWVQGTQP*GERELSGTAMGA
PGSSLPQAGRAGRRACCMGWGRAD*KGQSCLAR
QICAPCLSSLGSQAAKARVAWPGALQASLSLLL
HPWPVSSPGVPATPGSLLYIFETSFYSL*R*YTI
FVKRVCIYV*GAAGLQCACTWRAGARRLDGLML
PPLPWSREAGRGSWLLRGICPSPNPHPTLVPAL
*NSLCEGESAVQ**TVFTQ*TKS

Frame 1

AALGRTAGGEAPPLRKV*GAPPGEGGCLATGRW
LGGYPA**AREAARPQPAHPGLRRGAAPGPGAL
PGAPESHFGPVPRKTWSQLWGRRAGLDPSS*PEE
RPSASPSPSLCAGRRRPLCPGGEWRTRQSPTAT
FWAFGEFRANQRHLLGVSGLQHHRQAWGWPSQS
QIADLRQFPPPCVPH*NLEPH*EVPLGFRTPPPH
PGLVLK*KKEKQKPTKSIPATSGRVLLAPSRRR
RAKGRARERGLGSRVAGGRGCGAAALDPGDGGG
SKRGGWFLSFAIPVSPSGLPACRVA*SLRPELVF
LPATARPAELPASPQPPPLPTCDTKDLPGAAPA
CLCLRRI*ISFSPFRILSWLWILEENH*PETRL
SE*AGVLDNGLVEPIPIIKMSQSNRELVVDFLSY
KLSQKGYSWSQFSDVEENRTEAPEGTESEMETP
SAINGNPSWHLADSPAVNGATGHSSSLDAREVI
PMAAVKQALREAGDEFELRYRRAFSDLTSQLHIT
PGTAYQSFEQDTFVELYGNNAAAESRKGQERFN
RWFLTGMTVAGVVLLGSLFSRK*PDTDHPLYPP
TPFSAPPHPPSSRHCHQENHYMQPMPTCPSQGWA
QIWSLAASFLEFITLL*DPHTSVPLASEFTKFP
QNLSKGGWQVWKGLWLGAGGPYLIGATLTP*PP
*KCFSARELESFQNLFPRKETRLPLF*CLWPQN*
SFSPHSPHTNLGSLSFHPYPLRAI*GPLLTRDS
GCLG*RCKDQDSLLTSGLARVLTPSPNVLQKPL
ARGQPHPGGRGL*LQEAPHAKARVALAVQHHPSP
FPSLAPMTILRDQLGPRQMPQSCLWPQLPHFLQ
EQPVASLPWAAPHGGFRGLSPEVKGSYQEQLWE
PQGLPYLRQEGQEGEPAAWGGVGLTRRASPAWPG
RSVPHACPAWAARLPRPEWPGQELFRPPSLFCS
TLGLSHPQGSQPPRALCCTYLRLVFIPCEDDIL
FLLSVSVFMCEELLACSARARGELVPGDWTA*CS
LPCPGPGKLAEGPGS*GASAPPPTPTPHLFQLF
EIVCVKVKVQFSNKLCLLSEQRA

Frame 2

LRWGGPPGARPLLSGRSRGRPRGRAVA*QRGGG
SAGTRPSELEKPLGRSRPTLGSGEVQPPAPEPS
RGRQKATLGLSPGKRGLSCGAVEQASTPLPDLR
RGPAPHPHPVFVQGAGGHCVRAGNGGPGNPQLPR
SGPLGNSEQTSGICWGSPAFNITDRPGGGLPKV
RLQI*GSFPLPASLTETLNPIEKSL*GFGRLHL
TLGWCLNRKKKNKNQLNPYQPPPGEYSWLPVGGG
EPRGVQERGGWAPGWQEAAAAERPPSIRAMEEE
ASEGAGS*ASQFLCRLLGSQPAGSHDPSGRSWF
FCQPPRGRLSYRHPRSHLLSRPVIQKIFRGLHLP
AFA*GGFESLSLPSESYLGFGS*KRITNQRRDS
VSEQVFWTMDWLSPSLL*KCLRATGSWWLTFSP
TSFPRKDTAGVSLVMWKRTGLRPQKGLNRRWRPP
VPSMATHPGTWQTAPR*MEPLATAAVWMPGR*S
PWQQ*SKR*GRQATSLNCGTGGHSVT*HPSSTS
PQGQHIRALNRILLWNSMGTMQQPRAERARNAST
AGS*RA*LWPAWFCWAHSSVGNDQTLTIHSTLP
PPSLLHHILRPAAIATRRTTTCSPCPPAHHRVG
PRSGPLQLVF*NLSHFCETPTPQFPWPQNSQNFH
KICPKEAGRYGRVCGWGQEGPT*LVQPLPLSLP
ENVFLPGSLKVFRTSSPERRLDCLCFDVCGLRI
DHFPPTLPTLTWVPFPSIPTP*EPFRGHF*LGIQ
AAWDKDARTRTPSSPLDWLESSLPVQMSSRSLW
LEASPTQEGGGYSYRKHPMPKLGWPLQFSTTLV
PSPPWLP*PY*GTNWAQDRCPRAVYGLSCLTSYK
SSLWHLCLGLLLMVGSGDSALR*KGAIRNSYGS
PRVFPTSGRKGRKESLLHGVG*G*LEGPVLPGQ
ADLCPMPVQPGQPGCQGQSGLARSSSGLPLSSAP
PLACLIPRGPSHPGLSAVHI*D*FLFLVKMIYY
FC*ACLYLCVRSCWLAVRVHVESWCPEIGRPDA
PSPALVQGSWPRVLAPEGHLPLPQPPPHTCSSSL
K*SV*R*KCSSVINCVYSVNKE

Sequence BCL2L1.dAug05

GGCTGCGCTGGGGCGGACCGCCGGGGGCGAGGCCCCTCCTCTCAGGAAGGTCTAGGGGGCGCCCCCGGGGGAGGGCGGTTGCCTAGCAACGGGGCGGTGG
CTCGGCGGGTACCCGGCCTAGTGAGCTCGAGAAGCCGCTAGGCCGCAGCCGGCCCACCCTGGGCTCCGGAGAGGTGCAGCCCCCGGCCCCGGAGCCCTCC
CGGGGGCGCCAGAAAGCCACTTTGGGCCTGTCCCCAGGAAAACGTGGTCTCAGCTGTGGGGCCGTCGAGCAGGCCTCGACCCCTCTTCCTGACCTGAGGA
GAGGCCCAGCGCCTCACCCTCACCCAGTCTTTGTGCAGGGCGCCGGCGGCCATTGTGTCCGGGCGGGGAATGGAGGACCCGGCAATCCCCAACTGCCACG
TTCTGGGCCTTTGGGGAATTCAGAGCAAACCAGCGGCATTTGTTGGGGGTCTCCGGCCTTCAACATCACAGACAGGCCTGGGGGTGGCCTTCCCAAAGTC
AGATTGCAGATCTGAGGCAGTTTCCCCCTCCCTGCGTCCCTCACTGAAACCTTGAACCCCATTGAGAAGTCCCTTTAGGGTTTCGGACGCCTCCACCTCA
CCCTGGGCTGGTGCTTAAATAGAAAAAAGAAAAACAAAAACCAACTAAATCCATACCAGCCACCTCCGGGAGAGTACTCCTGGCTCCCAGTAGGAGGCGG
AGAGCCAAGGGGCGTGCAAGAGAGAGGGGGCTGGGCTCCCGGGTGGCAGGAGGCCGCGGCTGCGGAGCGGCCGCCCTCGATCCGGGCGATGGAGGAGGAA
GCAAGCGAGGGGGCTGGTTCCTGAGCTTCGCAATTCCTGTGTCGCCTTCTGGGCTCCCAGCCTGCCGGGTCGCATGATCCCTCCGGCCGGAGCTGGTTTT
TTTGCCAGCCACCGCGAGGCCGGCTGAGTTACCGGCATCCCCGCAGCCACCTCCTCTCCCGACCTGTGATACAAAAGATCTTCCGGGGGCTGCACCTGCC
TGCCTTTGCCTAAGGCGGATTTGAATCTCTTTCTCTCCCTTCAGAATCTTATCTTGGCTTTGGATCTTAGAAGAGAATCACTAACCAGAGACGAGACTCA
GTGAGTGAGCAGGTGTTTTGGACAATGGACTGGTTGAGCCCATCCCTATTATAAAAATGTCTCAGAGCAACCGGGAGCTGGTGGTTGACTTTCTCTCCTA
CAAGCTTTCCCAGAAAGGATACAGCTGGAGTCAGTTTAGTGATGTGGAAGAGAACAGGACTGAGGCCCCAGAAGGGACTGAATCGGAGATGGAGACCCCC
AGTGCCATCAATGGCAACCCATCCTGGCACCTGGCAGACAGCCCCGCGGTGAATGGAGCCACTGGCCACAGCAGCAGTTTGGATGCCCGGGAGGTGATCC
CCATGGCAGCAGTAAAGCAAGCGCTGAGGGAGGCAGGCGACGAGTTTGAACTGCGGTACCGGCGGGCATTCAGTGACCTGACATCCCAGCTCCACATCAC
CCCAGGGACAGCATATCAGAGCTTTGAACAGGTAGTGAATGAACTCTTCCGGGATGGGGTAAACTGGGGTCGCATTGTGGCCTTTTTCTCCTTCGGCGGG
GCACTGTGCGTGGAAAGCGTAGACAAGGAGATGCAGGTATTGGTGAGTCGGATCGCAGCTTGGATGGCCACTTACCTGAATGACCACCTAGAGCCTTGGA
TCCAGGAGAACGGCGGCTGG
GATACTTTTGTGGAACTCTATGGGAACAATGCAGCAGCCGAGAGCCGAAAGGGCCAGGAACGCTTCAACCGCTGGTTCCT
GACGGGCATGACTGTGGCCGGCGTGGTTCTGCTGGGCTCACTCTTCAGTCGGAAATGACCAGACACTGACCATCCACTCTACCCTCCCACCCCCTTCTCT
GCTCCACCACATCCTCCGTCCAGCCGCCATTGCCACCAGGAGAACCACTACATGCAGCCCATGCCCACCTGCCCATCACAGGGTTGGGCCCAGATCTGGT
CCCTTGCAGCTAGTTTTCTAGAATTTATCACACTTCTGTGAGACCCCCACACCTCAGTTCCCTTGGCCTCAGAATTCACAAAATTTCCACAAAATCTGTC
CAAAGGAGGCTGGCAGGTATGGAAGGGTTTGTGGCTGGGGGCAGGAGGGCCCTACCTGATTGGTGCAACCCTTACCCCTTAGCCTCCCTGAAAATGTTTT
TCTGCCAGGGAGCTTGAAAGTTTTCAGAACCTCTTCCCCAGAAAGGAGACTAGATTGCCTTTGTTTTGATGTTTGTGGCCTCAGAATTGATCATTTTCCC
CCCACTCTCCCCACACTAACCTGGGTTCCCTTTCCTTCCATCCCTACCCCCTAAGAGCCATTTAGGGGCCACTTTTGACTAGGGATTCAGGCTGCTTGGG
ATAAAGATGCAAGGACCAGGACTCCCTCCTCACCTCTGGACTGGCTAGAGTCCTCACTCCCAGTCCAAATGTCCTCCAGAAGCCTCTGGCTAGAGGCCAG
CCCCACCCAGGAGGGAGGGGGCTATAGCTACAGGAAGCACCCCATGCCAAAGCTAGGGTGGCCCTTGCAGTTCAGCACCACCCTAGTCCCTTCCCCTCCC
TGGCTCCCATGACCATACTGAGGGACCAACTGGGCCCAAGACAGATGCCCCAGAGCTGTTTATGGCCTCAGCTGCCTCACTTCCTACAAGAGCAGCCTGT
GGCATCTTTGCCTTGGGCTGCTCCTCATGGTGGGTTCAGGGGACTCAGCCCTGAGGTGAAAGGGAGCTATCAGGAACAGCTATGGGAGCCCCAGGGTCTT
CCCTACCTCAGGCAGGAAGGGCAGGAAGGAGAGCCTGCTGCATGGGGTGGGGTAGGGCTGACTAGAAGGGCCAGTCCTGCCTGGCCAGGCAGATCTGTGC
CCCATGCCTGTCCAGCCTGGGCAGCCAGGCTGCCAAGGCCAGAGTGGCCTGGCCAGGAGCTCTTCAGGCCTCCCTCTCTCTTCTGCTCCACCCTTGGCCT
GTCTCATCCCCAGGGGTCCCAGCCACCCCGGGCTCTCTGCTGTACATATTTGAGACTAGTTTTTATTCCTTGTGAAGATGATATACTATTTTTGTTAAGC
GTGTCTGTATTTATGTGTGAGGAGCTGCTGGCTTGCAGTGCGCGTGCACGTGGAGAGCTGGTGCCCGGAGATTGGACGGCCTGATGCTCCCTCCCCTGCC
CTGGTCCAGGGAAGCTGGCCGAGGGTCCTGGCTCCTGAGGGGCATCTGCCCCTCCCCCAACCCCCACCCCACACTTGTTCCAGCTCTTTGAAATAGTCTG
TGTGAAGGTGAAAGTGCAGTTCAGTAATAAACTGTGTTTACTCAGTGAACAAAGAGCC
  • BCLX-3 (forward primer)
  • BCLX-2 (reverse primer)
  • Alternative donor

Frame 0

GCAGADRRGRGPSSQEGLGGAPGGGRLPSNGAV
ARRVPGLVSSRSR*AAAGPPWAPERCSPRPRSPP
GGARKPLWACPQENVVSAVGPSSRPRPLFLT*G
EAQRLTLTQSLCRAPAAIVSGRGMEDPAIPNCH
VLGLWGIQSKPAAFVGGLRPSTSQTGLGVAFPKS
DCRSEAVSPSLRPSLKP*TPLRSPFRVSDASTS
PWAGA*IEKRKTKTN*IHTSHLRESTPGSQ*EA
ESQGACKREGAGLPGGRRPRLRSGRPRSGRWRRK
QARGLVPELRNSCVAFWAPSLPGRMIPPAGAGF
FASHREAG*VTGIPAATSSPDL*YKRSSGGCTC
LPLPKADLNLFLSLQNLILALDLRRESLTRDETQ
*VSRCFGQWTG*AHPYYKNVSEQPGAGG*LSLL
QAFPERIQLESV**CGREQD*GPRRD*IGDGDP
QCHQWQPILAPGRQPRGEWSHWPQQQFGCPGGDP
HGSSKASAEGGRRRV*TAVPAGIQ*PDIPAPHH
PRDSISEL*TGSE*TLPGWGKLGSHCGLFLLRR
GTVRGKRRQGDAGIGESDRSLDGHLPE*PPRALD
PGERRL
GYFCGTLWEQCSSREPKGPGTLQPLVP
DGHDCGRRGSAGLTLQSEMTRH*PSTLPSHPLL
CSTTSSVQPPLPPGEPLHAAHAHLPITGLGPDLV
PCS*FSRIYHTSVRPPHLSSLGLRIHKISTKSV
QRRLAGMEGFVAGGRRALPDWCNPYPLASLKMF
FCQGA*KFSEPLPQKGD*IAFVLMFVASELIIFP
PLSPH*PGFPFLPSLPPKSHLGATFD*GFRLLG
IKMQGPGLPPHLWTG*SPHSQSKCPPEASG*RP
APPRREGAIATGSTPCQS*GGPCSSAPP*SLPLP
GSHDHTEGPTGPKTDAPELFMASAASLPTRAAC
GIFALGCSSWWVQGTQP*GERELSGTAMGAPGS
SLPQAGRAGRRACCMGWGRAD*KGQSCLARQICA
PCLSSLGSQAAKARVAWPGALQASLSLLLHPWP
VSSPGVPATPGSLLYIFETSFYSL*R*YTIFVK
RVCIYV*GAAGLQCACTWRAGARRLDGLMLPPLP
WSREAGRGSWLLRGICPSPNPHPTLVPAL*NSL
CEGESAVQ**TVFTQ*TKS

Frame 1

AALGRTAGGEAPPLRKV*GAPPGEGGCLATGRW
LGGYPA**AREAARPQPAHPGLRRGAAPGPGAL
PGAPESHFGPVPRKTWSQLWGRRAGLDPSS*PEE
RPSASPSPSLCAGRRRPLCPGGEWRTRQSPTAT
FWAFGEFRANQRHLLGVSGLQHHRQAWGWPSQS
QIADLRQFPPPCVPH*NLEPH*EVPLGFRTPPPH
PGLVLK*KKEKQKPTKSIPATSGRVLLAPSRRR
RAKGRARERGLGSRVAGGRGCGAAALDPGDGGG
SKRGGWFLSFAIPVSPSGLPACRVA*SLRPELVF
LPATARPAELPASPQPPPLPTCDTKDLPGAAPA
CLCLRRI*ISFSPFRILSWLWILEENH*PETRL
SE*AGVLDNGLVEPIPIIKMSQSNRELVVDFLSY
KLSQKGYSWSQFSDVEENRTEAPEGTESEMETP
SAINGNPSWHLADSPAVNGATGHSSSLDAREVI
PMAAVKQALREAGDEFELRYRRAFSDLTSQLHIT
PGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGG
ALCVESVDKEMQVLVSRIAAWMATYLNDHLEPW
IQENGGW
DTFVELYGNNAAAESRKGQERFNRWFL
TGMTVAGVVLLGSLFSRK*PDTDHPLYPPTPFS
APPHPPSSRHCHQENHYMQPMPTCPSQGWAQIW
SLAASFLEFITLL*DPHTSVPLASEFTKFPQNLS
KGGWQVWKGLWLGAGGPYLIGATLTP*PP*KCF
SARELESFQNLFPRKETRLPLF*CLWPQN*SFS
PHSPHTNLGSLSFHPYPLRAI*GPLLTRDSGCLG
*RCKDQDSLLTSGLARVLTPSPNVLQKPLARGQ
PHPGGRGL*LQEAPHAKARVALAVQHHPSPFPS
LAPMTILRDQLGPRQMPQSCLWPQLPHFLQEQPV
ASLPWAAPHGGFRGLSPEVKGSYQEQLWEPQGL
PYLRQEGQEGEPAAWGGVGLTRRASPAWPGRSV
PHACPAWAARLPRPEWPGQELFRPPSLFCSTLGL
SHPQGSQPPRALCCTYLRLVFIPCEDDILFLLS
VSVFMCEELLACSARARGELVPGDWTA*CSLPC
PGPGKLAEGPGS*GASAPPPTPTPHLFQLFEIVC
VKVKVQFSNKLCLLSEQRA

Frame 2

LRWGGPPGARPLLSGRSRGRPRGRAVA*QRGGG
SAGTRPSELEKPLGRSRPTLGSGEVQPPAPEPS
RGRQKATLGLSPGKRGLSCGAVEQASTPLPDLR
RGPAPHPHPVFVQGAGGHCVRAGNGGPGNPQLPR
SGPLGNSEQTSGICWGSPAFNITDRPGGGLPKV
RLQI*GSFPLPASLTETLNPIEKSL*GFGRLHL
TLGWCLNRKKKNKNQLNPYQPPPGEYSWLPVGGG
EPRGVQERGGWAPGWQEAAAAERPPSIRAMEEE
ASEGAGS*ASQFLCRLLGSQPAGSHDPSGRSWF
FCQPPRGRLSYRHPRSHLLSRPVIQKIFRGLHLP
AFA*GGFESLSLPSESYLGFGS*KRITNQRRDS
VSEQVFWTMDWLSPSLL*KCLRATGSWWLTFSP
TSFPRKDTAGVSLVMWKRTGLRPQKGLNRRWRPP
VPSMATHPGTWQTAPR*MEPLATAAVWMPGR*S
PWQQ*SKR*GRQATSLNCGTGGHSVT*HPSSTS
PQGQHIRALNR**MNSSGMG*TGVALWPFSPSAG
HCAWKA*TRRCRYW*VGSQLGWPLT*MTT*SLG
SRRTAAG
ILLWNSMGTMQQPRAERARNASTAGS
*RA*LWPAWFCWAHSSVGNDQTLTIHSTLPPPSL
LHHILRPAAIATRRTTTCSPCPPAHHRVGPRSG
PLQLVF*NLSHFCETPTPQFPWPQNSQNFHKIC
PKEAGRYGRVCGWGQEGPT*LVQPLPLSLPENVF
LPGSLKVFRTSSPERRLDCLCFDVCGLRIDHFP
PTLPTLTWVPFPSIPTP*EPFRGHF*LGIQAAW
DKDARTRTPSSPLDWLESSLPVQMSSRSLWLEAS
PTQEGGGYSYRKHPMPKLGWPLQFSTTLVPSPP
WLP*PY*GTNWAQDRCPRAVYGLSCLTSYKSSL
WHLCLGLLLMVGSGDSALR*KGAIRNSYGSPRVF
PTSGRKGRKESLLHGVG*G*LEGPVLPGQADLC
PMPVQPGQPGCQGQSGLARSSSGLPLSSAPPLA
CLIPRGPSHPGLSAVHI*D*FLFLVKMIYYFC*A
CLYLCVRSCWLAVRVHVESWCPEIGRPDAPSPA
LVQGSWPRVLAPEGHLPLPQPPPHTCSSSLK*S
V*R*KCSSVINCVYSVNKE

Sequence BCL2L1.cAug05

GGCTGCGCTGGGGCGGACCGCCGGGGGCGAGGCCCCTCCTCTCAGGAAGGTCTAGGGGGCGCCCCCGGGGGAGGGCGGTTGCCTAGCAACGGGGCGGTGG
CTCGGCGGGTACCCGGCCTAGTGAGCTCGAGAAGCCGCTAGGCCGCAGCCGGCCCACCCTGGGCTCCGGAGAGGTGCAGCCCCCGGCCCCGGAGCCCTCC
CGGGGGCGCCAGAAAGCCACTTTGGGCCTGTCCCCAGGAAAACGTGGTCTCAGCTGTGGGGCCGTCGAGCAGGCCTCGACCCCTCTTCCTGACCTGAGGA
GAGGCCCAGCGCCTCACCCTCACCCAGTCTTTGTGCAGGGCGCCGGCGGCCATTGTGTCCGGGCGGGGAATGGAGGACCCGGCAATCCCCAACTGCCACG
TTCTGGGCCTTTGGGGAATTCAGAGCAAACCAGCGGCATTTGTTGGGGGTCTCCGGCCTTCAACATCACAGACAGGCCTGGGGGTGGCCTTCCCAAAGTC
AGATTGCAGATCTGAGGCAGTTTCCCCCTCCCTGCGTCCCTCACTGAAACCTTGAACCCCATTGAGAAGTCCCTTTAGGGTTTCGGACGCCTCCACCTCA
CCCTGGGCTGGTGCTTAAATAGAAAAAAGAAAAACAAAAACCAACTAAATCCATACCAGCCACCTCCGGGAGAGTACTCCTGGCTCCCAGTAGGAGGCGG
AGAGCCAAGGGGCGTGCAAGAGAGAGGGGGCTGGGCTCCCGGGTGGCAGGAGGCCGCGGCTGCGGAGCGGCCGCCCTCGATCCGGGCGATGGAGGAGGAA
GCAAGCGAGGGGGCTGGTTCCTGAGCTTCGCAATTCCTGTGTCGCCTTCTGGGCTCCCAGCCTGCCGGGTCGCATGATCCCTCCGGCCGGAGCTGGTTTT
TTTGCCAGCCACCGCGAGGCCGGCTGAGTTACCGGCATCCCCGCAGCCACCTCCTCTCCCGACCTGTGATACAAAAGATCTTCCGGGGGCTGCACCTGCC
TGCCTTTGCCTAAGGCGGATTTGAATAATCTTATCTTGGCTTTGGATCTTAGAAGAGAATCACTAACCAGAGACGAGACTCAGTGAGTGAGCAGGTGTTT
TGGACAATGGACTGGTTGAGCCCATCCCTATTATAAAAATGTCTCAGAGCAACCGGGAGCTGGTGGTTGACTTTCTCTCCTACAAGCTTTCCCAGAAAGG
ATACAGCTGGAGTCAGTTTAGTGATGTGGAAGAGAACAGGACTGAGGCCCCAGAAGGGACTGAATCGGAGATGGAGACCCCCAGTGCCATCAATGGCAAC
CCATCCTGGCACCTGGCAGACAGCCCCGCGGTGAATGGAGCCACTGGCCACAGCAGCAGTTTGGATGCCCGGGAGGTGATCCCCATGGCAGCAGTAAAGC
AAGCG
CTGAGGGAGGCAGGCGACGAGTTTGAACTGCGGTACCGGCGGGCATTCAGTGACCTGACATCCCAGCTCCACATCACCCCAGGGACAGCATATCA
GAGCTTTGAACAGGTAGTGAATGAACTCTTCCGGGATGGGGTAAACTGGGGTCGCATTGTGGCCTTTTTCTCCTTCGGCGGGGCACTGTGCGTGGAAAGC
GTAGACAAGGAGATGCAGGTATTGGTGAGTCGGATCGCAGCTTGGATGGCCACTTACCTGAATGACCACCTAGAGCCTTGGATCCAGGAGAACGGCGGCT
GG
GATACTTTTGTGGAACTCTATGGGAACAATGCAGCAGCCGAGAGCCGAAAGGGCCAGGAACGCTTCAACCGCTGGTTCCTGACGGGCATGACTGTGGC
CGGCGTGGTTCTGCTGGGCTCACTCTTCAGTCGGAAATGACCAGACACTGACCATCCACTCTACCCTCCCACCCCCTTCTCTGCTCCACCACATCCTCCG
TCCAGCCGCCATTGCCACCAGGAGAACCACTACATGCAGCCCATGCCCACCTGCCCATCACAGGGTTGGGCCCAGATCTGGTCCCTTGCAGCTAGTTTTC
TAGAATTTATCACACTTCTGTGAGACCCCCACACCTCAGTTCCCTTGGCCTCAGAATTCACAAAATTTCCACAAAATCTGTCCAAAGGAGGCTGGCAGGT
ATGGAAGGGTTTGTGGCTGGGGGCAGGAGGGCCCTACCTGATTGGTGCAACCCTTACCCCTTAGCCTCCCTGAAAATGTTTTTCTGCCAGGGAGCTTGAA
AGTTTTCAGAACCTCTTCCCCAGAAAGGAGACTAGATTGCCTTTGTTTTGATGTTTGTGGCCTCAGAATTGATCATTTTCCCCCCACTCTCCCCACACTA
ACCTGGGTTCCCTTTCCTTCCATCCCTACCCCCTAAGAGCCATTTAGGGGCCACTTTTGACTAGGGATTCAGGCTGCTTGGGATAAAGATGCAAGGACCA
GGACTCCCTCCTCACCTCTGGACTGGCTAGAGTCCTCACTCCCAGTCCAAATGTCCTCCAGAAGCCTCTGGCTAGAGGCCAGCCCCACCCAGGAGGGAGG
GGGCTATAGCTACAGGAAGCACCCCATGCCAAAGCTAGGGTGGCCCTTGCAGTTCAGCACCACCCTAGTCCCTTCCCCTCCCTGGCTCCCATGACCATAC
TGAGGGACCAACTGGGCCCAAGACAGATGCCCCAGAGCTGTTTATGGCCTCAGCTGCCTCACTTCCTACAAGAGCAGCCTGTGGCATCTTTGCCTTGGGC
TGCTCCTCATGGTGGGTTCAGGGGACTCAGCCCTGAGGTGAAAGGGAGCTATCAGGAACAGCTATGGGAGCCCCAGGGTCTTCCCTACCTCAGGCAGGAA
GGGCAGGAAGGAGAGCCTGCTGCATGGGGTGGGGTAGGGCTGACTAGAAGGGCCAGTCCTGCCTGGCCAGGCAGATCTGTGCCCCATGCCTGTCCAGCCT
GGGCAGCCAGGCTGCCAAGGCCAGAGTGGCCTGGCCAGGAGCTCTTCAGGCCTCCCTCTCTCTTCTGCTCCACCCTTGGCCTGTCTCATCCCCAGGGGTC
CCAGCCACCCCGGGCTCTCTGCTGTACATATTTGAGACTAGTTTTTATTCCTTGTGAAGATGATATACTATTTTTGTTAAGCGTGTCTGTATTTATGTGT
GAGGAGCTGCTGGCTTGCAGTGCGCGTGCACGTGGAGAGCTGGTGCCCGGAGATTGGACGGCCTGATGCTCCCTCCCCTGCCCTGGTCCAGGGAAGCTGG
CCGAGGGTCCTGGCTCCTGAGGGGCATCTGCCCCTCCCCCAACCCCCACCCCACACTTGTTCCAGCTCTTTGAAATAGTCTGTGTGAAGGTGAAAGTGCA
GTTCAGTAATAAACTGTGTTTACTCAGTGAACAAAGAGCC
  • BCLX-3 (forward primer)
  • BCLX-2 (reverse primer)
  • Alternative donor

Frame 0

GCAGADRRGRGPSSQEGLGGAPGGGRLPSNGAV
ARRVPGLVSSRSR*AAAGPPWAPERCSPRPRSPP
GGARKPLWACPQENVVSAVGPSSRPRPLFLT*G
EAQRLTLTQSLCRAPAAIVSGRGMEDPAIPNCH
VLGLWGIQSKPAAFVGGLRPSTSQTGLGVAFPKS
DCRSEAVSPSLRPSLKP*TPLRSPFRVSDASTS
PWAGA*IEKRKTKTN*IHTSHLRESTPGSQ*EA
ESQGACKREGAGLPGGRRPRLRSGRPRSGRWRRK
QARGLVPELRNSCVAFWAPSLPGRMIPPAGAGF
FASHREAG*VTGIPAATSSPDL*YKRSSGGCTC
LPLPKADLNNLILALDLRRESLTRDETQ*VSRCF
GQWTG*AHPYYKNVSEQPGAGG*LSLLQAFPER
IQLESV**CGREQD*GPRRD*IGDGDPQCHQWQ
PILAPGRQPRGEWSHWPQQQFGCPGGDPHGSSKA
S
AEGGRRRV*TAVPAGIQ*PDIPAPHHPRDSIS
EL*TGSE*TLPGWGKLGSHCGLFLLRRGTVRGK
RRQGDAGIGESDRSLDGHLPE*PPRALDPGERRL
GYFCGTLWEQCSSREPKGPGTLQPLVPDGHDCG
RRGSAGLTLQSEMTRH*PSTLPSHPLLCSTTSS
VQPPLPPGEPLHAAHAHLPITGLGPDLVPCS*FS
RIYHTSVRPPHLSSLGLRIHKISTKSVQRRLAG
MEGFVAGGRRALPDWCNPYPLASLKMFFCQGA*
KFSEPLPQKGD*IAFVLMFVASELIIFPPLSPH*
PGFPFLPSLPPKSHLGATFD*GFRLLGIKMQGP
GLPPHLWTG*SPHSQSKCPPEASG*RPAPPRRE
GAIATGSTPCQS*GGPCSSAPP*SLPLPGSHDHT
EGPTGPKTDAPELFMASAASLPTRAACGIFALG
CSSWWVQGTQP*GERELSGTAMGAPGSSLPQAG
RAGRRACCMGWGRAD*KGQSCLARQICAPCLSSL
GSQAAKARVAWPGALQASLSLLLHPWPVSSPGV
PATPGSLLYIFETSFYSL*R*YTIFVKRVCIYV
*GAAGLQCACTWRAGARRLDGLMLPPLPWSREAG
RGSWLLRGICPSPNPHPTLVPAL*NSLCEGESA
VQ**TVFTQ*TKS

Frame 1

AALGRTAGGEAPPLRKV*GAPPGEGGCLATGRW
LGGYPA**AREAARPQPAHPGLRRGAAPGPGAL
PGAPESHFGPVPRKTWSQLWGRRAGLDPSS*PEE
RPSASPSPSLCAGRRRPLCPGGEWRTRQSPTAT
FWAFGEFRANQRHLLGVSGLQHHRQAWGWPSQS
QIADLRQFPPPCVPH*NLEPH*EVPLGFRTPPPH
PGLVLK*KKEKQKPTKSIPATSGRVLLAPSRRR
RAKGRARERGLGSRVAGGRGCGAAALDPGDGGG
SKRGGWFLSFAIPVSPSGLPACRVA*SLRPELVF
LPATARPAELPASPQPPPLPTCDTKDLPGAAPA
CLCLRRI*IILSWLWILEENH*PETRLSE*AGV
LDNGLVEPIPIIKMSQSNRELVVDFLSYKLSQKG
YSWSQFSDVEENRTEAPEGTESEMETPSAINGN
PSWHLADSPAVNGATGHSSSLDAREVIPMAAVK
QA
LREAGDEFELRYRRAFSDLTSQLHITPGTAYQ
SFEQVVNELFRDGVNWGRIVAFFSFGGALCVES
VDKEMQVLVSRIAAWMATYLNDHLEPWIQENGG
W
DTFVELYGNNAAAESRKGQERFNRWFLTGMTVA
GVVLLGSLFSRK*PDTDHPLYPPTPFSAPPHPP
SSRHCHQENHYMQPMPTCPSQGWAQIWSLAASF
LEFITLL*DPHTSVPLASEFTKFPQNLSKGGWQV
WKGLWLGAGGPYLIGATLTP*PP*KCFSARELE
SFQNLFPRKETRLPLF*CLWPQN*SFSPHSPHT
NLGSLSFHPYPLRAI*GPLLTRDSGCLG*RCKDQ
DSLLTSGLARVLTPSPNVLQKPLARGQPHPGGR
GL*LQEAPHAKARVALAVQHHPSPFPSLAPMTI
LRDQLGPRQMPQSCLWPQLPHFLQEQPVASLPWA
APHGGFRGLSPEVKGSYQEQLWEPQGLPYLRQE
GQEGEPAAWGGVGLTRRASPAWPGRSVPHACPA
WAARLPRPEWPGQELFRPPSLFCSTLGLSHPQGS
QPPRALCCTYLRLVFIPCEDDILFLLSVSVFMC
EELLACSARARGELVPGDWTA*CSLPCPGPGKL
AEGPGS*GASAPPPTPTPHLFQLFEIVCVKVKVQ
FSNKLCLLSEQRA

Frame 2

LRWGGPPGARPLLSGRSRGRPRGRAVA*QRGGG
SAGTRPSELEKPLGRSRPTLGSGEVQPPAPEPS
RGRQKATLGLSPGKRGLSCGAVEQASTPLPDLR
RGPAPHPHPVFVQGAGGHCVRAGNGGPGNPQLPR
SGPLGNSEQTSGICWGSPAFNITDRPGGGLPKV
RLQI*GSFPLPASLTETLNPIEKSL*GFGRLHL
TLGWCLNRKKKNKNQLNPYQPPPGEYSWLPVGGG
EPRGVQERGGWAPGWQEAAAAERPPSIRAMEEE
ASEGAGS*ASQFLCRLLGSQPAGSHDPSGRSWF
FCQPPRGRLSYRHPRSHLLSRPVIQKIFRGLHLP
AFA*GGFE*SYLGFGS*KRITNQRRDSVSEQVF
WTMDWLSPSLL*KCLRATGSWWLTFSPTSFPRK
DTAGVSLVMWKRTGLRPQKGLNRRWRPPVPSMAT
HPGTWQTAPR*MEPLATAAVWMPGR*SPWQQ*S
KR
*GRQATSLNCGTGGHSVT*HPSSTSPQGQHI
RALNR**MNSSGMG*TGVALWPFSPSAGHCAWKA
*TRRCRYW*VGSQLGWPLT*MTT*SLGSRRTAA
G
ILLWNSMGTMQQPRAERARNASTAGS*RA*LW
PAWFCWAHSSVGNDQTLTIHSTLPPPSLLHHILR
PAAIATRRTTTCSPCPPAHHRVGPRSGPLQLVF
*NLSHFCETPTPQFPWPQNSQNFHKICPKEAGR
YGRVCGWGQEGPT*LVQPLPLSLPENVFLPGSLK
VFRTSSPERRLDCLCFDVCGLRIDHFPPTLPTL
TWVPFPSIPTP*EPFRGHF*LGIQAAWDKDART
RTPSSPLDWLESSLPVQMSSRSLWLEASPTQEGG
GYSYRKHPMPKLGWPLQFSTTLVPSPPWLP*PY
*GTNWAQDRCPRAVYGLSCLTSYKSSLWHLCLG
LLLMVGSGDSALR*KGAIRNSYGSPRVFPTSGRK
GRKESLLHGVG*G*LEGPVLPGQADLCPMPVQP
GQPGCQGQSGLARSSSGLPLSSAPPLACLIPRG
PSHPGLSAVHI*D*FLFLVKMIYYFC*ACLYLCV
RSCWLAVRVHVESWCPEIGRPDAPSPALVQGSW
PRVLAPEGHLPLPQPPPHTCSSSLK*SV*R*KC
SSVINCVYSVNKE

Sequence BCL2L1.bAug05

CGCGCACTCCCTTTGCGTCTCGGGCTCGCGCGCGTTGCCGCGGCACCGGAAGTGACTGAGCTTGCAAGTTCCCCTGTCTCTTCAGGGGAAACTGAGGCCG
GCTTGTTCGGGAGAGACGGCGCGAGCAGTCAGCCAGAATCTTATCTTGGCTTTGGATCTTAGAAGAGAATCACTAACCAGAGACGAGACTCAGTGAGTGA
GCAGGTGTTTTGGACAATGGACTGGTTGAGCCCATCCCTATTATAAAAATGTCTCAGAGCAACCGGGAGCTGGTGGTTGACTTTCTCTCCTACAAGCTTT
CCCAGAAAGGATACAGCTGGAGTCAGTTTAGTGATGTGGAAGAGAACAGGACTGAGGCCCCAGAAGGGACTGAATCGGAGATGGAGACCCCCAGTGCCAT
CAATGGCAACCCATCCTGGCACCTGGCAGACAGCCCCGCGGTGAATGGAGCCACTGGCCACAGCAGCAGTTTGGATGCCCGGGAGGTGATCCCCATGGCA
GCAGTAAAGCAAGCG
CTGAGGGAGGCAGGCGACGAGTTTGAACTGCGGTACCGGCGGGCATTCAGTGACCTGACATCCCAGCTCCACATCACCCCAGGGA
CAGCATATCAGAGCTTTGAACAGGTAGTGAATGAACTCTTCCGGGATGGGGTAAACTGGGGTCGCATTGTGGCCTTTTTCTCCTTCGGCGGGGCACTGTG
CGTGGAAAGCGTAGACAAGGAGATGCAGGTATTGGTGAGTCGGATCGCAGCTTGGATGGCCACTTACCTGAATGACCACCTAGAGCCTTGGATCCAGGAG
AACGGCGGCTGG
GATACTTTTGTGGAACTCTATGGGAACAATGCAGCAGCCGAGAGCCGAAAGGGCCAGGAACGCTTCAACCGCTGGTTCCTGACGGGCA
TGACTGTGGCCGGCGTGGTTCTGCTGGGCTCACTCTTCAGTCGGAAATGACCAGACACTGACCATCCACTCTACCCTCCCACCCCCTTCTCTGCTCCACC
ACATCCTCCGTCCAGCCGCCATTGCCACCAGGAGAACCACTACATGCAGCCCATGCCCACCTGCCCATCACAGGGTTGGGCCCAGATCTGGTCCCTTGCA
GCTAGTTTTCTAGAATTTATCACACTTCTGTGAGACCCCCACACTTGTTCCAGCTCTTTGAAATAGTCTGTGTGAAGGTGAAAGTGCAGTTCAGTAATAA
ACTGTGTTTACTCAGTGAACAAAGAGCC
  • BCLX-3 (forward primer)
  • BCLX-2 (reverse primer)
  • Alternative donor

Frame 0

RALPLRLGLARVAAAPEVTELASSPVSSGETEA
GLFGRDGASSQPESYLGFGS*KRITNQRRDSVSE
QVFWTMDWLSPSLL*KCLRATGSWWLTFSPTSF
PRKDTAGVSLVMWKRTGLRPQKGLNRRWRPPVP
SMATHPGTWQTAPR*MEPLATAAVWMPGR*SPWQ
Q*SKR
*GRQATSLNCGTGGHSVT*HPSSTSPQG
QHIRALNR**MNSSGMG*TGVALWPFSPSAGHC
AWKA*TRRCRYW*VGSQLGWPLT*MTT*SLGSRR
TAAG
ILLWNSMGTMQQPRAERARNASTAGS*RA
*LWPAWFCWAHSSVGNDQTLTIHSTLPPPSLLH
HILRPAAIATRRTTTCSPCPPAHHRVGPRSGPLQ
LVF*NLSHFCETPTLVPAL*NSLCEGESAVQ**
TVFTQ*TKS

Frame 1

AHSLCVSGSRALPRHRK*LSLQVPLSLQGKLRP
ACSGETARAVSQNLILALDLRRESLTRDETQ*V
SRCFGQWTG*AHPYYKNVSEQPGAGG*LSLLQAF
PERIQLESV**CGREQD*GPRRD*IGDGDPQCH
QWQPILAPGRQPRGEWSHWPQQQFGCPGGDPHG
SSKAS
AEGGRRRV*TAVPAGIQ*PDIPAPHHPRD
SISEL*TGSE*TLPGWGKLGSHCGLFLLRRGTV
RGKRRQGDAGIGESDRSLDGHLPE*PPRALDPG
ERRL
GYFCGTLWEQCSSREPKGPGTLQPLVPDGH
DCGRRGSAGLTLQSEMTRH*PSTLPSHPLLCST
TSSVQPPLPPGEPLHAAHAHLPITGLGPDLVPC
S*FSRIYHTSVRPPHLFQLFEIVCVKVKVQFSNK
LCLLSEQRA

Frame 2

RTPFASRARARCRGTGSD*ACKFPCLFRGN*GR
LVRERRREQSARILSWLWILEENH*PETRLSE*
AGVLDNGLVEPIPIIKMSQSNRELVVDFLSYKL
SQKGYSWSQFSDVEENRTEAPEGTESEMETPSAI
NGNPSWHLADSPAVNGATGHSSSLDAREVIPMA
AVKQA
LREAGDEFELRYRRAFSDLTSQLHITPG
TAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALC
VESVDKEMQVLVSRIAAWMATYLNDHLEPWIQE
NGGW
DTFVELYGNNAAAESRKGQERFNRWFLTG
MTVAGVVLLGSLFSRK*PDTDHPLYPPTPFSAPP
HPPSSRHCHQENHYMQPMPTCPSQGWAQIWSLA
ASFLEFITLL*DPHTCSSSLK*SV*R*KCSSVI
NCVYSVNKE

Sequence BCL2L1.aAug05

CGCGCACTCCCTTTGCGTCTCGGGCTCGCGCGCGTTGCCGCGGCACCGGAAGTGACTGAGCTTGCAAGTTCCCCTGTCTCTTCAGGGGAAACTGAGGCCG
GCTTGTTCGGGAGAGACGGCGCGAGCAGTCAGCCAGGTAGGCCGGCAGCCAGGTAGGCCGGCCCGGGTCCGCGGCGCGGAACTCGGCCGCGAAGAGCTCT
TGCGTCTGGAAGCTACCGGGCCGATGAAGGGGGATGTGGCCCCCCACGGCTCGCGGGGCTCGCAGAATCTTATCTTGGCTTTGGATCTTAGAAGAGAATC
ACTAACCAGAGACGAGACTCAGTGAGTGAGCAGGTGTTTTGGACAATGGACTGGTTGAGCCCATCCCTATTATAAAAATGTCTCAGAGCAACCGGGAGCT
GGTGGTTGACTTTCTCTCCTACAAGCTTTCCCAGAAAGGATACAGCTGGAGTCAGTTTAGTGATGTGGAAGAGAACAGGACTGAGGCCCCAGAAGGGACT
GAATCGGAGATGGAGACCCCCAGTGCCATCAATGGCAACCCATCCTGGCACCTGGCAGACAGCCCCGCGGTGAATGGAGCCACTGGCCACAGCAGCAGTT
TGGATGCCCGGGAGGTGATCCCCATGGCAGCAGTAAAGCAAGCGCTGAGGGAGGCAGGCGACGAGTTTGAACTGCGGTACCGGCGGGCATTCAGTGACCT
GACATCCCAGCTCCACATCACCCCAGGGACAGCATATCAGAGCTTTGAACAGGTAGTGAATGAACTCTTCCGGGATGGGGTAAACTGGGGTCGCATTGTG
GCCTTTTTCTCCTTCGGCGGGGCACTGTGCGTGGAAAGCGTAGACAAGGAGATGCAGGTATTGGTGAGTCGGATCGCAGCTTGGATGGCCACTTACCTGA
ATGACCACCTAGAGCCTTGGATCCAGGAGAACGGCGGCTGG
GATACTTTTGTGGAACTCTATGGGAACAATGCAGCAGCCGAGAGCCGAAAGGGCCAGGA
ACGCTTCAACCGCTGGTTCCTGACGGGCATGACTGTGGCCGGCGTGGTTCTGCTGGGCTCACTCTTCAGTCGGAAATGACCAGACACTGACCATCCACTC
TACCCTCCCACCCCCTTCTCTGCTCCACCACATCCTCCGTCCAGCCGCCATTGCCACCAGGAGAACCACTACATGCAGCCCATGCCCACCTGCCCATCAC
AGGGTTGGGCCCAGATCTGGTCCCTTGCAGCTAGTTTTCTAGAATTTATCACACTTCTGTGAGACCCCCACACCTCAGTTCCCTTGGCCTCAGAATTCAC
AAAATTTCCACAAAATCTGTCCAAAGGAGGCTGGCAGGTATGGAAGGGTTTGTGGCTGGGGGCAGGAGGGCCCTACCTGATTGGTGCAACCCTTACCCCT
TAGCCTCCCTGAAAATGTTTTTCTGCCAGGGAGCTTGAAAGTTTTCAGAACCTCTTCCCCAGAAAGGAGACTAGATTGCCTTTGTTTTGATGTTTGTGGC
CTCAGAATTGATCATTTTCCCCCCACTCTCCCCACACTAACCTGGGTTCCCTTTCCTTCCATCCCTACCCCCTAAGAGCCATTTAGGGGCCACTTTTGAC
TAGGGATTCAGGCTGCTTGGGATAAAGATGCAAGGACCAGGACTCCCTCCTCACCTCTGGACTGGCTAGAGTCCTCACTCCCAGTCCAAATGTCCTCCAG
AAGCCTCTGGCTAGAGGCCAGCCCCACCCAGGAGGGAGGGGGCTATAGCTACAGGAAGCACCCCATGCCAAAGCTAGGGTGGCCCTTGCAGTTCAGCACC
ACCCTAGTCCCTTCCCCTCCCTGGCTCCCATGACCATACTGAGGGACCAACTGGGCCCAAGACAGATGCCCCAGAGCTGTTTATGGCCTCAGCTGCCTCA
CTTCCTACAAGAGCAGCCTGTGGCATCTTTGCCTTGGGCTGCTCCTCATGGTGGGTTCAGGGGACTCAGCCCTGAGGTGAAAGGGAGCTATCAGGAACAG
CTATGGGAGCCCCAGGGTCTTCCCTACCTCAGGCAGGAAGGGCAGGAAGGAGAGCCTGCTGCATGGGGTGGGGTAGGGCTGACTAGAAGGGCCAGTCCTG
CCTGGCCAGGCAGATCTGTGCCCCATGCCTGTCCAGCCTGGGCAGCCAGGCTGCCAAGGCCAGAGTGGCCTGGCCAGGAGCTCTTCAGGCCTCCCTCTCT
CTTCTGCTCCACCCTTGGCCTGTCTCATCCCCAGGGGTCCCAGCCACCCCGGGCTCTCTGCTGTACATATTTGAGACTAGTTTTTATTCCTTGTGAAGAT
GATATACTATTTTTGTTAAGCGTGTCTGTATTTATGTGTGAGGAGCTGCTGGCTTGCAGTGCGCGTGCACGTGGAGAGCTGGTGCCCGGAGATTGGACGG
CCTGATGCTCCCTCCCCTGCCCTGGTCCAGGGAAGCTGGCCGAGGGTCCTGGCTCCTGAGGGGCATCTGCCCCTCCCCCAACCCCCACCCCACACTTGTT
CCAGCTCTTTGAAATAGTCTGTGTGAAGGTGAAAGTGCAGTTCAGTAATAAACTGTGTTTACTCAGTGAACAAAGAGCC
  • BCLX-3 (forward primer)
  • BCLX-2 (reverse primer)
  • Alternative donor

Frame 0

RALPLRLGLARVAAAPEVTELASSPVSSGETEA
GLFGRDGASSQPGRPAAR*AGPGPRRGTRPRRAL
ASGSYRADEGGCGPPRLAGLAESYLGFGS*KRI
TNQRRDSVSEQVFWTMDWLSPSLL*KCLRATGS
WWLTFSPTSFPRKDTAGVSLVMWKRTGLRPQKGL
NRRWRPPVPSMATHPGTWQTAPR*MEPLATAAV
WMPGR*SPWQQ*SKR*GRQATSLNCGTGGHSVT
*HPSSTSPQGQHIRALNR**MNSSGMG*TGVALW
PFSPSAGHCAWKA*TRRCRYW*VGSQLGWPLT*
MTT*SLGSRRTAAG
ILLWNSMGTMQQPRAERAR
NASTAGS*RA*LWPAWFCWAHSSVGNDQTLTIHS
TLPPPSLLHHILRPAAIATRRTTTCSPCPPAHH
RVGPRSGPLQLVF*NLSHFCETPTPQFPWPQNS
QNFHKICPKEAGRYGRVCGWGQEGPT*LVQPLPL
SLPENVFLPGSLKVFRTSSPERRLDCLCFDVCG
LRIDHFPPTLPTLTWVPFPSIPTP*EPFRGHF*
LGIQAAWDKDARTRTPSSPLDWLESSLPVQMSSR
SLWLEASPTQEGGGYSYRKHPMPKLGWPLQFST
TLVPSPPWLP*PY*GTNWAQDRCPRAVYGLSCL
TSYKSSLWHLCLGLLLMVGSGDSALR*KGAIRNS
YGSPRVFPTSGRKGRKESLLHGVG*G*LEGPVL
PGQADLCPMPVQPGQPGCQGQSGLARSSSGLPL
SSAPPLACLIPRGPSHPGLSAVHI*D*FLFLVKM
IYYFC*ACLYLCVRSCWLAVRVHVESWCPEIGR
PDAPSPALVQGSWPRVLAPEGHLPLPQPPPHTC
SSSLK*SV*R*KCSSVINCVYSVNKE

Frame 1

AHSLCVSGSRALPRHRK*LSLQVPLSLQGKLRP
ACSGETARAVSQVGRQPGRPARVRGAELGREEL
LRLEATGPMKGDVAPHGSRGSQNLILALDLRRES
LTRDETQ*VSRCFGQWTG*AHPYYKNVSEQPGA
GG*LSLLQAFPERIQLESV**CGREQD*GPRRD
*IGDGDPQCHQWQPILAPGRQPRGEWSHWPQQQF
GCPGGDPHGSSKASAEGGRRRV*TAVPAGIQ*P
DIPAPHHPRDSISEL*TGSE*TLPGWGKLGSHC
GLFLLRRGTVRGKRRQGDAGIGESDRSLDGHLPE
*PPRALDPGERRL
GYFCGTLWEQCSSREPKGPG
TLQPLVPDGHDCGRRGSAGLTLQSEMTRH*PST
LPSHPLLCSTTSSVQPPLPPGEPLHAAHAHLPIT
GLGPDLVPCS*FSRIYHTSVRPPHLSSLGLRIH
KISTKSVQRRLAGMEGFVAGGRRALPDWCNPYP
LASLKMFFCQGA*KFSEPLPQKGD*IAFVLMFVA
SELIIFPPLSPH*PGFPFLPSLPPKSHLGATFD
*GFRLLGIKMQGPGLPPHLWTG*SPHSQSKCPP
EASG*RPAPPRREGAIATGSTPCQS*GGPCSSAP
P*SLPLPGSHDHTEGPTGPKTDAPELFMASAAS
LPTRAACGIFALGCSSWWVQGTQP*GERELSGT
AMGAPGSSLPQAGRAGRRACCMGWGRAD*KGQSC
LARQICAPCLSSLGSQAAKARVAWPGALQASLS
LLLHPWPVSSPGVPATPGSLLYIFETSFYSL*R
*YTIFVKRVCIYV*GAAGLQCACTWRAGARRLDG
LMLPPLPWSREAGRGSWLLRGICPSPNPHPTLV
PAL*NSLCEGESAVQ**TVFTQ*TKS

Frame 2

RTPFASRARARCRGTGSD*ACKFPCLFRGN*GR
LVRERRREQSAR*AGSQVGRPGSAARNSAAKSS
CVWKLPGR*RGMWPPTARGARRILSWLWILEEN
H*PETRLSE*AGVLDNGLVEPIPIIKMSQSNREL
VVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGT
ESEMETPSAINGNPSWHLADSPAVNGATGHSSS
LDAREVIPMAAVKQALREAGDEFELRYRRAFSDL
TSQLHITPGTAYQSFEQVVNELFRDGVNWGRIV
AFFSFGGALCVESVDKEMQVLVSRIAAWMATYL
NDHLEPWIQENGGW
DTFVELYGNNAAAESRKGQE
RFNRWFLTGMTVAGVVLLGSLFSRK*PDTDHPL
YPPTPFSAPPHPPSSRHCHQENHYMQPMPTCPS
QGWAQIWSLAASFLEFITLL*DPHTSVPLASEFT
KFPQNLSKGGWQVWKGLWLGAGGPYLIGATLTP
*PP*KCFSARELESFQNLFPRKETRLPLF*CLW
PQN*SFSPHSPHTNLGSLSFHPYPLRAI*GPLLT
RDSGCLG*RCKDQDSLLTSGLARVLTPSPNVLQ
KPLARGQPHPGGRGL*LQEAPHAKARVALAVQH
HPSPFPSLAPMTILRDQLGPRQMPQSCLWPQLPH
FLQEQPVASLPWAAPHGGFRGLSPEVKGSYQEQ
LWEPQGLPYLRQEGQEGEPAAWGGVGLTRRASP
AWPGRSVPHACPAWAARLPRPEWPGQELFRPPSL
FCSTLGLSHPQGSQPPRALCCTYLRLVFIPCED
DILFLLSVSVFMCEELLACSARARGELVPGDWT
A*CSLPCPGPGKLAEGPGS*GASAPPPTPTPHLF
QLFEIVCVKVKVQFSNKLCLLSEQRA

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