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Sequences

Sequence BID.iAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC CGCGGCTGGAGGGTGGTCAACAACGGTTCCAGCCTCAGGGATGAGTGCATCACAAACCTACTGGTGTTTGGCTTCCTCCAAAGCTGTTCTGACAACAGCT TCCGCAGAGAGCTGGACGCACTGGGCCACGAGCTGCCAGTGCTGGCTCCCCAGTGGGAGGGCTACGATGAGCTGCAGACTGATGGCAACCGCAGCAGCCA CTCCCGCTTGGGAAGAATAGAGATTCTGAAAGTCAAGAAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCA TCCCTCCGGGCCTGGTGAACGGCCTGGCCCTGCAGCTCAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCT GCTGCAGGCCTACCCTAGAGACATGGAGAAGGAGAAGACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTC CGTGATGTCTTTCACACAACAGTGAATTTTATTAACCAGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCA GAAGTGTGACTGGCTAAAGCTCGATGTGGTCACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGG CTGGAAGATAGCTGTGACTTCTATTTTAAAGACAATGTTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATTTAC ACGTATTTGAATGGCCTTCATATCATCCACACATGAATCTGCACATCTGTAAATCTACACACGGTGCCTTTATTTCCACTGTGCAGGTTCCCACTTAAAA ATTAAATTGGAAAGCAGGTTTCAAGGAAGTAGAAACAAAATACAATTTTTTTGGTAAAAAAAAATTACTGTTTATTAAAGTACAACCATAGAGGATGGTC TTACAGCAGGCAGTATCCTGTTTGAGGAAAGCAAGAATCAGAGAAGGAACATACCCCTTACAAATGAAAAATTCCACTCAAAATAGGGACTATCTATCTT AATACTAAGGAACCAACAATCTTCCTGTTTAAAAAACCACATGGCACAGAGATTCTGAACTAAAGTGCTGCACTCAAATGATGGGAAGTCCGGCCCCAGT ACACAGGGGCTTGACTTTTTCAACTTCGTTTCCTTTGTTGGAGTCAAAAAGAACCACTTGTGGTTCTAAAAGGTGTGAAGGTGATTTAAGGGCCCAGGTC AGCCACTGTTTGTTTACAAAATCAGGTAACTAACTGCATACACTTTTTCTCTTTCCATGACATCAAGACTTTGCTAAAGACATGAAGCCACGGGTGCCAG AAGCTACTGCGATGCCCCGGGAGTTAGCCCCCTGGTAATAGCTGTAAACTTCCAATTTCTAGCCATACGCTCAGCTCATCCATGCCTCAGAAGTGCATCT GGAGAGAACAGGTTTCTAAGCATAAAAGATGAAAGAGCAGTTGGACTTTTTAAAAATTCAGCAAAGTGGTTCCCTCTCTTAGGGACAGTCAAAACCAAGT CACTTAGGTAGTACCAAAATAAATAAGGAAAAGCTTAGCTTTAGAAACAGTGCAACACTGGTCTGCTGTTCCAGTGGTAAGCTATGTCCCAGGAATCAGT TTAAAAGCACGACAGTGGATGCTGGGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACAACATGAGGCCACTGGAGACGCATATGAG TAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCAGAAAGGAAAAACAAACTCTATATTGTTC AGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAAGTGCTGCCGCGCAGTGTGGAGGCCACTG TTTGGAAATAAATCTTCCTAACACTACGACTTTTCATGTTTTGGAGTGGACTTTTAAAAAAGTTTTCCAACCACAATGGAAACAGGTTGAACCACACTGC GCCTACACATCCATCCATACGTCAGCCATTATAATCAGATTCTCACTGGGGGAGGCATTTTCTTCCCAAAGGAGCTGTATGCAGTCATCACCCGGAACTA ATGGGAAAGTGTTCTTAAGCAGCAAGTGACTCTGGACCACCTCTCTCACACACTGACTCTTCCACAGCATCTTCACCTGCTTCTGTTTCACTTGAATTCA TACAGTAGGCCACCATTTTATAACAGGTCTTAGTGTAAATTCTTCCAGACCAAGTCTGAGATAGTCTTGGTTGTAAAGCAAGACCGTCACCCCTTCTCCC AAAGCCAACATTATAAAAAGATTCCATTGTCTCAAACACAAATGTTCCAGTCTTGAGCACTTCCCAGCCATGGTGACTCGGGCATATCCTGGCAGTTGGT GGATTTTGCCCTGTAACACAATCCTTGTGGATATGATTCAAAGGTGACTTTAATTCAGAGAATGTGTTTTCCTTTCTGTTTTAAAAATATTTGAATTAAG TGATGGAAATTCTTTTGTTAAACATCAAAAGCTTTCTCCTTGAAAAGATGCTTGGTGTATCTGAAAGTCACGTGGGACATTTGGTGCATTCAGAAGGTCA AATCATTCCTGACCTCTCCTCTTAGGACCCAGCATTAACTGCTGCGATACTCAAGGCTTCCTTAAAGGATCACAGCACTGGCGCCTAGTTTTACTGTCCA GCAACTTTATTAGTTGTGCTAGCTGAGAATTGGAATATAGAGTCCTTTGAATGTTACGATCTTGTTTTCAAAACCTGGAGTCAAACCAATTAAGTATGGA CTTAACAAAGACAATTGATGATGTGAAATGATACCACCTGTCAAGGGCATAGTTACCATGTGGATAGAAAGATGAGTCCACTGATTATCTTCAAATCCCA TGTATTCTCTCTAGCACGTTGCTTCTGACAGAAAGAATAACTCACAGATTTGAAGTTTGTTCCTTTCCCCTGATGAAGAGTAGATTGGCCAAAAGGTAGA TGACAGGAAGGAAGAGGAGCCAGAATGACCCACAGTGATCAGTTCAGCAGTGCAGAGCGGCAGTGCAGAGGCTCATGGAACTCACACGGAAAAAGGAAAC ACATGCTGCTTAAAATGCACGATAACTTAATTATCCAAATTACCATTCAATTCCGGTATTTTTGAGATGAAAGCATTTGAGCCAACACTAAATTGACCTT AATTAAGGAATGAGGTAGGAAGAGGCACTTTTAATCTGGAGGAAGAAATAAATGGAAGACTGTAATAGGAAAAATACAGGTCTAGGAAAAAAATAATTTT TTTCCTTTGATGCTGGCCAAGGACCCCTCTACATAATACAGTTCTCCTGCTGGAAAGCATCAGGGCAAACAGAGTTATTCCAAACTCTGCAACAGGGAAG ACTGTACTTTGACCTTCTTTTCCTGGGGAAAGGGAACAACTAGTAATCTTTAAATGTCAAAACTTTTCTTCTAAATAGTACATTCATTAACCAGTTTCTT CTGGTGGTGCAAAGAACACTCACCACAGTGAGCAATACCACTATTCAATTTCCCCTTTGGAGAGGTGACAGCGGGGTAGAATCACCTGGAGTCAGCTGCT AGTCTTTAACTGATGACAAGGCCTTGCAAATACCCCTGAGAACAATTTCACTCTGAGCTCACAGGGAAGCAGCAGTCTGGTGTGGGCTCCTGTGGTGTAA CCATCAAATGTGGAAGACCTGATGGTGTTAGTGTGTGGGGATGCCGGGCTGAAATTCAACAGCCTTGCAAAAAGAAAGGGAAGATGGGATGTGTTAATAT TGTAGTGGCATGCACTTTCCAGCTCTCCATGGAGCTCTCTTTATATATGAGGTAATTGAATGTCACTATTCTGTACCATACAGCAGGTATTATCTAGCCA AGGTTATAATTACCATGAAGTGCTGTGGAATGTAGTAGGAGGCTTTTCACTGGG

BID.u.f.10 (forward primer)
BID.u.r.14 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP PRLEGGQQRFQPQG*VHHKPTGVWLPPKLF*QQL PQRAGRTGPRAASAGSPVGGLR*AAD*WQPQQP LPLGKNRDSESQEDIIRNIARHLAQVGDSMDRS IPPGLVNGLALQLRNTSRSEEDRNRDLATALEQL LQAYPRDMEKEKTMLVLALLLAKKVASHTPSLL RDVFHTTVNFINQNLRTYVRSLARNGMD*TDSS RSVTG*SSMWSQLYSCFQCRRSPGMSTAFLEKTG WKIAVTSILKTMLNL*PTLKYLH*YT*MKMSIY TYLNGLHIIHT*ICTSVNLHTVPLFPLCRFPLK N*IGKQVSRK*KQNTIFLVKKNYCLLKYNHRGWS YSRQYPV*GKQESEKEHTPYK*KIPLKIGTIYL NTKEPTIFLFKKPHGTEILN*SAALK*WEVRPQ YTGA*LFQLRFLCWSQKEPLVVLKGVKVI*GPRS ATVCLQNQVTNCIHFFSFHDIKTLLKT*SHGCQ KLLRCPGS*PPGNSCKLPISSHTLSSSMPQKCI WREQVSKHKR*KSSWTF*KFSKVVPSLRDSQNQV T*VVPK*IRKSLALETVQHWSAVPVVSYVPGIS LKARQWMLGPYHTHCCEQETPVTTT*GHWRRI* VRALTDS*FLLTRCFPVL*EFKIIRKEKQTLYCS ACNTYHARAGSIESGQKLTNTKKKCCRAVWRPL FGNKSS*HYDFSCFGVDF*KSFPTTMETG*TTL RLHIHPYVSHYNQILTGGGIFFPKELYAVITRN* WESVLKQQVTLDHLSHTLTLPQHLHLLLFHLNS YSRPPFYNRS*CKFFQTKSEIVLVVKQDRHPFS QSQHYKKIPLSQTQMFQS*ALPSHGDSGISWQLV DFAL*HNPCGYDSKVTLIQRMCFPFCFKNI*IK *WKFFC*TSKAFSLKRCLVYLKVTWDIWCIQKV KSFLTSPLRTQH*LLRYSRLP*RITALAPSFTVQ QLY*LC*LRIGI*SPLNVTILFSKPGVKPIKYG LNKDN**CEMIPPVKGIVTMWIER*VH*LSSNP MYSL*HVASDRKNNSQI*SLFLSPDEE*IGQKVD DRKEEEPE*PTVISSAVQSGSAEAHGTHTEKGN TCCLKCTIT*LSKLPFNSGIFEMKAFEPTLN*P *LRNEVGRGTFNLEEEINGRL**EKYRSRKKIIF FL*CWPRTPLHNTVLLLESIRANRVIPNSATGK TVL*PSFPGEREQLVIFKCQNFSSK*YIH*PVS SGGAKNTHHSEQYHYSISPLER*QRGRITWSQLL VFN**QGLANTPENNFTLSSQGSSSLVWAPVV* PSNVEDLMVLVCGDAGLKFNSLAKRKGRWDVLI L*WHALSSSPWSSLYI*GN*MSLFCTIQQVLSSQ GYNYHEVLWNVVGGFSL

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP RGWRVVNNGSSLRDECITNLLVFGFLQSCSDNS FRRELDALGHELPVLAPQWEGYDELQTDGNRSSH SRLGRIEILKVKKTSSGILPGTSPRSGTAWTVA SLRAW*TAWPCSSGTPAGRRRTGTGTWPLPWSS CCRPTLETWRRRRPCWCWPCCWPRRWPVTRRPCS VMSFTQQ*ILLTRTYAPT*GA*PEMGWTERTVP EV*LAKARCGHSCIAASSVDGALACQQRS*RRQ AGR*L*LLF*RQC*TYNPL*NIYINILE*KCPFT RI*MAFISSTHESAHL*IYTRCLYFHCAGSHLK IKLESRFQGSRNKIQFFW*KKITVY*STTIEDG LTAGSILFEESKNQRRNIPLTNEKFHSK*GLSIL ILRNQQSSCLKNHMAQRF*TKVLHSNDGKSGPS TQGLDFFNFVSFVGVKKNHLWF*KV*R*FKGPG QPLFVYKIR*LTAYTFSLSMTSRLC*RHEATGAR SYCDAPGVSPLVIAVNFQFLAIRSAHPCLRSAS GENRFLSIKDERAVGLFKNSAKWFPLLGTVKTK SLR*YQNK*GKA*L*KQCNTGLLFQW*AMSQESV *KHDSGCWVHITHIAVNRKLL*PQHEATGDAYE *GH*RTHDFFLPDAFLFFKSLKSSERKNKLYIV QHAIHTTLGLAQLKVGKSLQILKRSAAAQCGGHC LEINLPNTTTFHVLEWTFKKVFQPQWKQVEPHC AYTSIHTSAIIIRFSLGEAFSSQRSCMQSSPGT NGKVFLSSK*LWTTSLTH*LFHSIFTCFCFT*IH TVGHHFITGLSVNSSRPSLR*SWL*SKTVTPSP KANIIKRFHCLKHKCSSLEHFPAMVTRAYPGSW WILPCNTILVDMIQR*L*FRECVFLSVLKIFELS DGNSFVKHQKLSP*KDAWCI*KSRGTFGAFRRS NHS*PLLLGPSINCCDTQGFLKGSQHWRLVLLS SNFISCAS*ELEYRVL*MLRSCFQNLESNQLSMD LTKTIDDVK*YHLSRA*LPCG*KDESTDYLQIP CILSSTLLLTERITHRFEVCSFPLMKSRLAKR* MTGRKRSQNDPQ*SVQQCRAAVQRLMELTRKKET HAA*NAR*LNYPNYHSIPVFLR*KHLSQH*IDL N*GMR*EEALLIWRKK*MEDCNRKNTGLGKK*F FSFDAGQGPLYIIQFSCWKASGQTELFQTLQQGR LYFDLLFLGKGNN**SLNVKTFLLNSTFINQFL LVVQRTLTTVSNTTIQFPLWRGDSGVESPGVSC *SLTDDKALQIPLRTISL*AHREAAVWCGLLWCN HQMWKT*WC*CVGMPG*NSTALQKEREDGMC*Y CSGMHFPALHGALFIYEVIECHYSVPYSRYYLA KVIITMKCCGM**EAFHW

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP AAGGWSTTVPASGMSASQTYWCLASSKAVLTTA SAESWTHWATSCQCWLPSGRATMSCRLMATAAA TPAWEE*RF*KSRRHHPEYCQAPRPGRGQHGP*H PSGPGERPGPAAQEHQPVGGGPEQGPGHCPGAA AAGLP*RHGEGEDHAGAGPAAGQEGGQSHAVLA P*CLSHNSEFY*PEPTHLREELSQKWDGLNGQFQ KCDWLKLDVVTAV*LLPV*TEPWHVNSVPREDR LEDSCDFYFKDNVKLITHFKISTLIYLNENVHL HVFEWPSYHPHMNLHICKSTHGAFISTVQVPT*K LNWKAGFKEVETKYNFFGKKKLLFIKVQP*RMV LQQAVSCLRKARIREGTYPLQMKNSTQNRDYLS *Y*GTNNLPV*KTTWHRDSELKCCTQMMGSPAPV HRGLTFSTSFPLLESKRTTCGSKRCEGDLRAQV SHCLFTKSGN*LHTLFLFP*HQDFAKDMKPRVP EATAMPRELAPW**L*TSNF*PYAQLIHASEVHL ERTGF*A*KMKEQLDFLKIQQSGSLS*GQSKPS HLGSTKINKEKLSFRNSATLVCCSSGKLCPRNQ FKSTTVDAGSISHTLL*TGNSCDHNMRPLETHMS KGTDGLMISSYQMLSCSLRV*NHQKGKTNSILF SMQYIPR*GWLN*KWAKAYKY*KEVLPRSVEAT VWK*IFLTLRLFMFWSGLLKKFSNHNGNRLNHTA PTHPSIRQPL*SDSHWGRHFLPKGAVCSHHPEL MGKCS*AASDSGPPLSHTDSSTASSPASVSLEF IQ*ATIL*QVLV*ILPDQV*DSLGCKARPSPLLP KPTL*KDSIVSNTNVPVLSTSQPW*LGHILAVG GFCPVTQSLWI*FKGDFNSENVFSFLF*KYLN* VMEILLLNIKSFLLEKMLGVSESHVGHLVHSEGQ IIPDLSS*DPALTAAILKASLKDHSTGA*FYCP ATLLVVLAENWNIESFECYDLVFKTWSQTN*VW T*QRQLMM*NDTTCQGHSYHVDRKMSPLIIFKSH VFSLARCF*QKE*LTDLKFVPFP**RVDWPKGR *QEGRGARMTHSDQFSSAERQCRGSWNSHGKRK HMLLKMHDNLIIQITIQFRYF*DESI*ANTKLTL IKE*GRKRHF*SGGRNKWKTVIGKIQV*EKNNF FPLMLAKDPST*YSSPAGKHQGKQSYSKLCNRE DCTLTFFSWGKGTTSNL*MSKLFF*IVHSLTSFF WWCKEHSPQ*AIPLFNFPFGEVTAG*NHLESAA SL*LMTRPCKYP*EQFHSELTGKQQSGVGSCGV TIKCGRPDGVSVWGCRAEIQQPCKKKGKMGCVNI VVACTFQLSMELSLYMR*LNVTILYHTAGII*P RL*LP*SAVECSRRLFTG

Sequence BID.fAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC CGCGGCTGGAGGGTGGTCGCCACTGGGACACTGTGAACCAGGAGTGAGTCGGAGCTGCCGCGCTGCCCAGGCCATGGACTGTGAGGTCAACAACGGTTCC AGCCTCAGGGATGAGTGCATCACAAACCTACTGGTGTTTGGCTTCCTCCAAAGCTGTTCTGACAACAGCTTCCGCAGAGAGCTGGACGCACTGGGCCACG AGCTGCCAGTGCTGGCTCCCCAGTGGGAGGGCTACGATGAGCTGCAGACTGATGGCAACCGCAGCAGCCACTCCCGCTTGGGAAGAATAGAGGCAGGGGC GTCAGACAATAACACAGCAAGTGCTGAGGAAGAAACGGAGGCGGCAGGGAGCGTGGCAGTTGAGCGTGGCCTTCATGGAGCTGCGACAGTGATTCTGAAA GTCAAGAAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTGAACGGCCTGGCCCT GCAGCTCAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGGAGAAG GAGAAGACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACAACAGTGAATTTTA TTAACCAGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGATGTGGTC ACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTGTGACTTCTATTTTAAAG ACAATGTTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATTTACACGTATTTGAATGGCCTTCATATCATCCACA CATGAATCTGCACATCTGTAAATCTACACACGGTGCCTTTATTTCCACTGTGCAGGTTCCCACTTAAAAATTAAATTGGAAAGCAGGTTTCAAGGAAGTA GAAACAAAATACAATTTTTTTGGTAAAAAAAAATTACTGTTTATTAAAGTACAACCATAGAGGATGGTCTTACAGCAGGCAGTATCCTGTTTGAGGAAAG CAAGAATCAGAGAAGGAACATACCCCTTACAAATGAAAAATTCCACTCAAAATAGGGACTATCTATCTTAATACTAAGGAACCAACAATCTTCCTGTTTA AAAAACCACATGGCACAGAGATTCTGAACTAAAGTGCTGCACTCAAATGATGGGAAGTCCGGCCCCAGTACACAGGGGCTTGACTTTTTCAACTTCGTTT CCTTTGTTGGAGTCAAAAAGAACCACTTGTGGTTCTAAAAGGTGTGAAGGTGATTTAAGGGCCCAGGTCAGCCACTGTTTGTTTACAAAATCAGGTAACT AACTGCATACACTTTTTCTCTTTCCATGACATCAAGACTTTGCTAAAGACATGAAGCCACGGGTGCCAGAAGCTACTGCGATGCCCCGGGAGTTAGCCCC CTGGTAATAGCTGTAAACTTCCAATTTCTAGCCATACGCTCAGCTCATCCATGCCTCAGAAGTGCATCTGGAGAGAACAGGTTTCTAAGCATAAAAGATG AAAGAGCAGTTGGACTTTTTAAAAATTCAGCAAAGTGGTTCCCTCTCTTAGGGACAGTCAAAACCAAGTCACTTAGGTAGTACCAAAATAAATAAGGAAA AGCTTAGCTTTAGAAACAGTGCAACACTGGTCTGCTGTTCCAGTGGTAAGCTATGTCCCAGGAATCAGTTTAAAAGCACGACAGTGGATGCTGGGTCCAT ATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACAACATGAGGCCACTGGAGACGCATATGAGTAAGGGCACTGACGGACTCATGATTTCTTCT TACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCAGAAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGGCTGGC TCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAAGTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAAATAAATCTTCCTAACACTACGACT TTTCATGTTTTGGAGTGGACTTTTAAAAAAGTTTTCCAACCACAATGGAAACAGGTTGAACCACACTGCGCCTACACATCCATCCATACGTCAGCCATTA TAATCAGATTCTCACTGGGGGAGGCATTTTCTTCCCAAAGGAGCTGTATGCAGTCATCACCCGGAACTAATGGGAAAGTGTTCTTAAGCAGCAAGTGACT CTGGACCACCTCTCTCACACACTGACTCTTCCACAGCATCTTCACCTGCTTCTGTTTCACTTGAATTCATACAGTAGGCCACCATTTTATAACAGGTCTT AGTGTAAATTCTTCCAGACCAAGTCTGAGATAGTCTTGGTTGTAAAGCAAGACCGTCACCCCTTCTCCCAAAGCCAACATTATAAAAAGATTCCATTGTC TCAAACACAAATGTTCCAGTCTTGAGCACTTCCCAGCCATGGTGACTCGGGCATATCCTGGCAGTTGGTGGATTTTGCCCTGTAACACAATCCTTGTGGA TATGATTCAAAGGTGACTTTAATTCAGAGAATGTGTTTTCCTTTCTGTTTTAAAAATATTTGAATTAAGTGATGGAAATTCTTTTGTTAAACATCAAAAG CTTTCTCCTTGAAAAGATGCTTGGTGTATCTGAAAGTCACGTGGGACATTTGGTGCATTCAGAAGGTCAAATCATTCCTGACCTCTCCTCTTAGGACCCA GCATTAACTGCTGCGATACTCAAGGCTTCCTTAAAGGATCACAGCACTGGCGCCTAGTTTTACTGTCCAGCAACTTTATTAGTTGTGCTAGCTGAGAATT GGAATATAGAGTCCTTTGAATGTTACGATCTTGTTTTCAAAACCTGGAGTCAAACCAATTAAGTATGGACTTAACAAAGACAATTGATGATGTGAAATGA TACCACCTGTCAAGGGCATAGTTACCATGTGGATAGAAAGATGAGTCCACTGATTATCTTCAAATCCCATGTATTCTCTCTAGCACGTTGCTTCTGACAG AAAGAATAACTCACAGATTTGAAGTTTGTTCCTTTCCCCTGATGAAGAGTAGATTGGCCAAAAGGTAGATGACAGGAAGGAAGAGGAGCCAGAATGACCC ACAGTGATCAGTTCAGCAGTGCAGAGCGGCAGTGCAGAGGCTCATGGAACTCACACGGAAAAAGGAAACACATGCTGCTTAAAATGCACGATAACTTAAT TATCCAAATTACCATTCAATTCCGGTATTTTTGAGATGAAAGCATTTGAGCCAACACTAAATTGACCTTAATTAAGGAATGAGGTAGGAAGAGGCACTTT TAATCTGGAGGAAGAAATAAATGGAAGACTGTAATAGGAAAAATACAGGTCTAGGAAAAAAATAATTTTTTTCCTTTGATGCTGGCCAAGGACCCCTCTA CATAATACAGTTCTCCTGCTGGAAAGCATCAGGGCAAACAGAGTTATTCCAAACTCTGCAACAGGGAAGACTGTACTTTGACCTTCTTTTCCTGGGGAAA GGGAACAACTAGTAATCTTTAAATGTCAAAACTTTTCTTCTAAATAGTACATTCATTAACCAGTTTCTTCTGGTGGTGCAAAGAACACTCACCACAGTGA GCAATACCACTATTCAATTTCCCCTTTGGAGAGGTGACAGCGGGGTAGAATCACCTGGAGTCAGCTGCTAGTCTTTAACTGATGACAAGGCCTTGCAAAT ACCCCTGAGAACAATTTCACTCTGAGCTCACAGGGAAGCAGCAGTCTGGTGTGGGCTCCTGTGGTGTAACCATCAAATGTGGAAGACCTGATGGTGTTAG TGTGTGGGGATGCCGGGCTGAAATTCAACAGCCTTGCAAAAAGAAAGGGAAGATGGGATGTGTTAATATTGTAGTGGCATGCACTTTCCAGCTCTCCATG GAGCTCTCTTTATATATGAGGTAATTGAATGTCACTATTCTGTACCATACAGCAGGTATTATCTAGCCAAGGTTATAATTACCATGAAGTGCTGTGGAAT GTAGTAGGAGGCTTTTCACTGGG

BID.u.f.10 (forward primer)
BID.u.r.14 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP PRLEGGRHWDTVNQE*VGAAALPRPWTVRSTTVP ASGMSASQTYWCLASSKAVLTTASAESWTHWAT SCQCWLPSGRATMSCRLMATAAATPAWEE*RQG RQTITQQVLRKKRRRQGAWQLSVAFMELRQ*F*K SRRHHPEYCQAPRPGRGQHGP*HPSGPGERPGP AAQEHQPVGGGPEQGPGHCPGAAAAGLP*RHGE GEDHAGAGPAAGQEGGQSHAVLAP*CLSHNSEFY *PEPTHLREELSQKWDGLNGQFQKCDWLKLDVV TAV*LLPV*TEPWHVNSVPREDRLEDSCDFYFK DNVKLITHFKISTLIYLNENVHLHVFEWPSYHPH MNLHICKSTHGAFISTVQVPT*KLNWKAGFKEV ETKYNFFGKKKLLFIKVQP*RMVLQQAVSCLRK ARIREGTYPLQMKNSTQNRDYLS*Y*GTNNLPV* KTTWHRDSELKCCTQMMGSPAPVHRGLTFSTSF PLLESKRTTCGSKRCEGDLRAQVSHCLFTKSGN *LHTLFLFP*HQDFAKDMKPRVPEATAMPRELAP W**L*TSNF*PYAQLIHASEVHLERTGF*A*KM KEQLDFLKIQQSGSLS*GQSKPSHLGSTKINKE KLSFRNSATLVCCSSGKLCPRNQFKSTTVDAGSI SHTLL*TGNSCDHNMRPLETHMSKGTDGLMISS YQMLSCSLRV*NHQKGKTNSILFSMQYIPR*GW LN*KWAKAYKY*KEVLPRSVEATVWK*IFLTLRL FMFWSGLLKKFSNHNGNRLNHTAPTHPSIRQPL *SDSHWGRHFLPKGAVCSHHPELMGKCS*AASD SGPPLSHTDSSTASSPASVSLEFIQ*ATIL*QVL V*ILPDQV*DSLGCKARPSPLLPKPTL*KDSIV SNTNVPVLSTSQPW*LGHILAVGGFCPVTQSLW I*FKGDFNSENVFSFLF*KYLN*VMEILLLNIKS FLLEKMLGVSESHVGHLVHSEGQIIPDLSS*DP ALTAAILKASLKDHSTGA*FYCPATLLVVLAEN WNIESFECYDLVFKTWSQTN*VWT*QRQLMM*ND TTCQGHSYHVDRKMSPLIIFKSHVFSLARCF*Q KE*LTDLKFVPFP**RVDWPKGR*QEGRGARMT HSDQFSSAERQCRGSWNSHGKRKHMLLKMHDNLI IQITIQFRYF*DESI*ANTKLTLIKE*GRKRHF *SGGRNKWKTVIGKIQV*EKNNFFPLMLAKDPS T*YSSPAGKHQGKQSYSKLCNREDCTLTFFSWGK GTTSNL*MSKLFF*IVHSLTSFFWWCKEHSPQ* AIPLFNFPFGEVTAG*NHLESAASL*LMTRPCK YP*EQFHSELTGKQQSGVGSCGVTIKCGRPDGVS VWGCRAEIQQPCKKKGKMGCVNIVVACTFQLSM ELSLYMR*LNVTILYHTAGII*PRL*LP*SAVE CSRRLFTG

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP RGWRVVATGTL*TRSESELPRCPGHGL*GQQRF QPQG*VHHKPTGVWLPPKLF*QQLPQRAGRTGPR AASAGSPVGGLR*AAD*WQPQQPLPLGKNRGRG VRQ*HSKC*GRNGGGRERGS*AWPSWSCDSDSE SQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLAL QLRNTSRSEEDRNRDLATALEQLLQAYPRDMEK EKTMLVLALLLAKKVASHTPSLLRDVFHTTVNF INQNLRTYVRSLARNGMD*TDSSRSVTG*SSMWS QLYSCFQCRRSPGMSTAFLEKTGWKIAVTSILK TMLNL*PTLKYLH*YT*MKMSIYTYLNGLHIIH T*ICTSVNLHTVPLFPLCRFPLKN*IGKQVSRK* KQNTIFLVKKNYCLLKYNHRGWSYSRQYPV*GK QESEKEHTPYK*KIPLKIGTIYLNTKEPTIFLF KKPHGTEILN*SAALK*WEVRPQYTGA*LFQLRF LCWSQKEPLVVLKGVKVI*GPRSATVCLQNQVT NCIHFFSFHDIKTLLKT*SHGCQKLLRCPGS*P PGNSCKLPISSHTLSSSMPQKCIWREQVSKHKR* KSSWTF*KFSKVVPSLRDSQNQVT*VVPK*IRK SLALETVQHWSAVPVVSYVPGISLKARQWMLGP YHTHCCEQETPVTTT*GHWRRI*VRALTDS*FLL TRCFPVL*EFKIIRKEKQTLYCSACNTYHARAG SIESGQKLTNTKKKCCRAVWRPLFGNKSS*HYD FSCFGVDF*KSFPTTMETG*TTLRLHIHPYVSHY NQILTGGGIFFPKELYAVITRN*WESVLKQQVT LDHLSHTLTLPQHLHLLLFHLNSYSRPPFYNRS *CKFFQTKSEIVLVVKQDRHPFSQSQHYKKIPLS QTQMFQS*ALPSHGDSGISWQLVDFAL*HNPCG YDSKVTLIQRMCFPFCFKNI*IK*WKFFC*TSK AFSLKRCLVYLKVTWDIWCIQKVKSFLTSPLRTQ H*LLRYSRLP*RITALAPSFTVQQLY*LC*LRI GI*SPLNVTILFSKPGVKPIKYGLNKDN**CEM IPPVKGIVTMWIER*VH*LSSNPMYSL*HVASDR KNNSQI*SLFLSPDEE*IGQKVDDRKEEEPE*P TVISSAVQSGSAEAHGTHTEKGNTCCLKCTIT* LSKLPFNSGIFEMKAFEPTLN*P*LRNEVGRGTF NLEEEINGRL**EKYRSRKKIIFFL*CWPRTPL HNTVLLLESIRANRVIPNSATGKTVL*PSFPGE REQLVIFKCQNFSSK*YIH*PVSSGGAKNTHHSE QYHYSISPLER*QRGRITWSQLLVFN**QGLAN TPENNFTLSSQGSSSLVWAPVV*PSNVEDLMVL VCGDAGLKFNSLAKRKGRWDVLIL*WHALSSSPW SSLYI*GN*MSLFCTIQQVLSSQGYNYHEVLWN VVGGFSL

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP AAGGWSPLGHCEPGVSRSCRAAQAMDCEVNNGS SLRDECITNLLVFGFLQSCSDNSFRRELDALGH ELPVLAPQWEGYDELQTDGNRSSHSRLGRIEAGA SDNNTASAEEETEAAGSVAVERGLHGAATVILK VKKTSSGILPGTSPRSGTAWTVASLRAW*TAWP CSSGTPAGRRRTGTGTWPLPWSSCCRPTLETWRR RRPCWCWPCCWPRRWPVTRRPCSVMSFTQQ*IL LTRTYAPT*GA*PEMGWTERTVPEV*LAKARCG HSCIAASSVDGALACQQRS*RRQAGR*L*LLF*R QC*TYNPL*NIYINILE*KCPFTRI*MAFISST HESAHL*IYTRCLYFHCAGSHLKIKLESRFQGS RNKIQFFW*KKITVY*STTIEDGLTAGSILFEES KNQRRNIPLTNEKFHSK*GLSILILRNQQSSCL KNHMAQRF*TKVLHSNDGKSGPSTQGLDFFNFV SFVGVKKNHLWF*KV*R*FKGPGQPLFVYKIR*L TAYTFSLSMTSRLC*RHEATGARSYCDAPGVSP LVIAVNFQFLAIRSAHPCLRSASGENRFLSIKD ERAVGLFKNSAKWFPLLGTVKTKSLR*YQNK*GK A*L*KQCNTGLLFQW*AMSQESV*KHDSGCWVH ITHIAVNRKLL*PQHEATGDAYE*GH*RTHDFF LPDAFLFFKSLKSSERKNKLYIVQHAIHTTLGLA QLKVGKSLQILKRSAAAQCGGHCLEINLPNTTT FHVLEWTFKKVFQPQWKQVEPHCAYTSIHTSAI IIRFSLGEAFSSQRSCMQSSPGTNGKVFLSSK*L WTTSLTH*LFHSIFTCFCFT*IHTVGHHFITGL SVNSSRPSLR*SWL*SKTVTPSPKANIIKRFHC LKHKCSSLEHFPAMVTRAYPGSWWILPCNTILVD MIQR*L*FRECVFLSVLKIFELSDGNSFVKHQK LSP*KDAWCI*KSRGTFGAFRRSNHS*PLLLGP SINCCDTQGFLKGSQHWRLVLLSSNFISCAS*EL EYRVL*MLRSCFQNLESNQLSMDLTKTIDDVK* YHLSRA*LPCG*KDESTDYLQIPCILSSTLLLT ERITHRFEVCSFPLMKSRLAKR*MTGRKRSQNDP Q*SVQQCRAAVQRLMELTRKKETHAA*NAR*LN YPNYHSIPVFLR*KHLSQH*IDLN*GMR*EEAL LIWRKK*MEDCNRKNTGLGKK*FFSFDAGQGPLY IIQFSCWKASGQTELFQTLQQGRLYFDLLFLGK GNN**SLNVKTFLLNSTFINQFLLVVQRTLTTV SNTTIQFPLWRGDSGVESPGVSC*SLTDDKALQI PLRTISL*AHREAAVWCGLLWCNHQMWKT*WC* CVGMPG*NSTALQKEREDGMC*YCSGMHFPALH GALFIYEVIECHYSVPYSRYYLAKVIITMKCCGM **EAFHW