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Sequences

Sequence BID.hAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC CGCGGCTGGAGGGTGATTCTGAAAGTCAAGAAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCC GGGCCTGGTGAACGGCCTGGCCCTGCAGCTCAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAG GCCTACCCTAGAGACATGGAGAAGGAGAAGACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATG TCTTTCACACAACAGTGAATTTTATTAACCAGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGT GACTGGCTAAAGCTCGATGTGGTCACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAG ATAGCTGTGACTTCTATTTTAAAGACAATGTTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATTTACACGTATT TGAATGGCCTTCATATCATCCACACATGAATCTGCACATCTGTAAATCTACACACGGTGCCTTTATTTCCACTGTGCAGGTTCCCACTTAAAAATTAAAT TGGAAAGCAGGTTTCAAGGAAGTAGAAACAAAATACAATTTTTTTGGTAAAAAAAAATTACTGTTTATTAAAGTACAACCATAGAGGATGGTCTTACAGC AGGCAGTATCCTGTTTGAGGAAAGCAAGAATCAGAGAAGGAACATACCCCTTACAAATGAAAAATTCCACTCAAAATAGGGACTATCTATCTTAATACTA AGGAACCAACAATCTTCCTGTTTAAAAAACCACATGGCACAGAGATTCTGAACTAAAGTGCTGCACTCAAATGATGGGAAGTCCGGCCCCAGTACACAGG GGCTTGACTTTTTCAACTTCGTTTCCTTTGTTGGAGTCAAAAAGAACCACTTGTGGTTCTAAAAGGTGTGAAGGTGATTTAAGGGCCCAGGTCAGCCACT GTTTGTTTACAAAATCAGGTAACTAACTGCATACACTTTTTCTCTTTCCATGACATCAAGACTTTGCTAAAGACATGAAGCCACGGGTGCCAGAAGCTAC TGCGATGCCCCGGGAGTTAGCCCCCTGGTAATAGCTGTAAACTTCCAATTTCTAGCCATACGCTCAGCTCATCCATGCCTCAGAAGTGCATCTGGAGAGA ACAGGTTTCTAAGCATAAAAGATGAAAGAGCAGTTGGACTTTTTAAAAATTCAGCAAAGTGGTTCCCTCTCTTAGGGACAGTCAAAACCAAGTCACTTAG GTAGTACCAAAATAAATAAGGAAAAGCTTAGCTTTAGAAACAGTGCAACACTGGTCTGCTGTTCCAGTGGTAAGCTATGTCCCAGGAATCAGTTTAAAAG CACGACAGTGGATGCTGGGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACAACATGAGGCCACTGGAGACGCATATGAGTAAGGGC ACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCAGAAAGGAAAAACAAACTCTATATTGTTCAGCATGC AATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAAGTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAA ATAAATCTTCCTAACACTACGACTTTTCATGTTTTGGAGTGGACTTTTAAAAAAGTTTTCCAACCACAATGGAAACAGGTTGAACCACACTGCGCCTACA CATCCATCCATACGTCAGCCATTATAATCAGATTCTCACTGGGGGAGGCATTTTCTTCCCAAAGGAGCTGTATGCAGTCATCACCCGGAACTAATGGGAA AGTGTTCTTAAGCAGCAAGTGACTCTGGACCACCTCTCTCACACACTGACTCTTCCACAGCATCTTCACCTGCTTCTGTTTCACTTGAATTCATACAGTA GGCCACCATTTTATAACAGGTCTTAGTGTAAATTCTTCCAGACCAAGTCTGAGATAGTCTTGGTTGTAAAGCAAGACCGTCACCCCTTCTCCCAAAGCCA ACATTATAAAAAGATTCCATTGTCTCAAACACAAATGTTCCAGTCTTGAGCACTTCCCAGCCATGGTGACTCGGGCATATCCTGGCAGTTGGTGGATTTT GCCCTGTAACACAATCCTTGTGGATATGATTCAAAGGTGACTTTAATTCAGAGAATGTGTTTTCCTTTCTGTTTTAAAAATATTTGAATTAAGTGATGGA AATTCTTTTGTTAAACATCAAAAGCTTTCTCCTTGAAAAGATGCTTGGTGTATCTGAAAGTCACGTGGGACATTTGGTGCATTCAGAAGGTCAAATCATT CCTGACCTCTCCTCTTAGGACCCAGCATTAACTGCTGCGATACTCAAGGCTTCCTTAAAGGATCACAGCACTGGCGCCTAGTTTTACTGTCCAGCAACTT TATTAGTTGTGCTAGCTGAGAATTGGAATATAGAGTCCTTTGAATGTTACGATCTTGTTTTCAAAACCTGGAGTCAAACCAATTAAGTATGGACTTAACA AAGACAATTGATGATGTGAAATGATACCACCTGTCAAGGGCATAGTTACCATGTGGATAGAAAGATGAGTCCACTGATTATCTTCAAATCCCATGTATTC TCTCTAGCACGTTGCTTCTGACAGAAAGAATAACTCACAGATTTGAAGTTTGTTCCTTTCCCCTGATGAAGAGTAGATTGGCCAAAAGGTAGATGACAGG AAGGAAGAGGAGCCAGAATGACCCACAGTGATCAGTTCAGCAGTGCAGAGCGGCAGTGCAGAGGCTCATGGAACTCACACGGAAAAAGGAAACACATGCT GCTTAAAATGCACGATAACTTAATTATCCAAATTACCATTCAATTCCGGTATTTTTGAGATGAAAGCATTTGAGCCAACACTAAATTGACCTTAATTAAG GAATGAGGTAGGAAGAGGCACTTTTAATCTGGAGGAAGAAATAAATGGAAGACTGTAATAGGAAAAATACAGGTCTAGGAAAAAAATAATTTTTTTCCTT TGATGCTGGCCAAGGACCCCTCTACATAATACAGTTCTCCTGCTGGAAAGCATCAGGGCAAACAGAGTTATTCCAAACTCTGCAACAGGGAAGACTGTAC TTTGACCTTCTTTTCCTGGGGAAAGGGAACAACTAGTAATCTTTAAATGTCAAAACTTTTCTTCTAAATAGTACATTCATTAACCAGTTTCTTCTGGTGG TGCAAAGAACACTCACCACAGTGAGCAATACCACTATTCAATTTCCCCTTTGGAGAGGTGACAGCGGGGTAGAATCACCTGGAGTCAGCTGCTAGTCTTT AACTGATGACAAGGCCTTGCAAATACCCCTGAGAACAATTTCACTCTGAGCTCACAGGGAAGCAGCAGTCTGGTGTGGGCTCCTGTGGTGTAACCATCAA ATGTGGAAGACCTGATGGTGTTAGTGTGTGGGGATGCCGGGCTGAAATTCAACAGCCTTGCAAAAAGAAAGGGAAGATGGGATGTGTTAATATTGTAGTG GCATGCACTTTCCAGCTCTCCATGGAGCTCTCTTTATATATGAGGTAATTGAATGTCACTATTCTGTACCATACAGCAGGTATTATCTAGCCAAGGTTAT AATTACCATGAAGTGCTGTGGAATGTAGTAGGAGGCTTTTCACTGGG

BID.u.f.10 (forward primer)
BID.u.r.14 (reverse primer)
Multiple exon skipping

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP PRLEGDSESQEDIIRNIARHLAQVGDSMDRSIPP GLVNGLALQLRNTSRSEEDRNRDLATALEQLLQ AYPRDMEKEKTMLVLALLLAKKVASHTPSLLRD VFHTTVNFINQNLRTYVRSLARNGMD*TDSSRSV TG*SSMWSQLYSCFQCRRSPGMSTAFLEKTGWK IAVTSILKTMLNL*PTLKYLH*YT*MKMSIYTY LNGLHIIHT*ICTSVNLHTVPLFPLCRFPLKN*I GKQVSRK*KQNTIFLVKKNYCLLKYNHRGWSYS RQYPV*GKQESEKEHTPYK*KIPLKIGTIYLNT KEPTIFLFKKPHGTEILN*SAALK*WEVRPQYTG A*LFQLRFLCWSQKEPLVVLKGVKVI*GPRSAT VCLQNQVTNCIHFFSFHDIKTLLKT*SHGCQKL LRCPGS*PPGNSCKLPISSHTLSSSMPQKCIWRE QVSKHKR*KSSWTF*KFSKVVPSLRDSQNQVT* VVPK*IRKSLALETVQHWSAVPVVSYVPGISLK ARQWMLGPYHTHCCEQETPVTTT*GHWRRI*VRA LTDS*FLLTRCFPVL*EFKIIRKEKQTLYCSAC NTYHARAGSIESGQKLTNTKKKCCRAVWRPLFG NKSS*HYDFSCFGVDF*KSFPTTMETG*TTLRLH IHPYVSHYNQILTGGGIFFPKELYAVITRN*WE SVLKQQVTLDHLSHTLTLPQHLHLLLFHLNSYS RPPFYNRS*CKFFQTKSEIVLVVKQDRHPFSQSQ HYKKIPLSQTQMFQS*ALPSHGDSGISWQLVDF AL*HNPCGYDSKVTLIQRMCFPFCFKNI*IK*W KFFC*TSKAFSLKRCLVYLKVTWDIWCIQKVKSF LTSPLRTQH*LLRYSRLP*RITALAPSFTVQQL Y*LC*LRIGI*SPLNVTILFSKPGVKPIKYGLN KDN**CEMIPPVKGIVTMWIER*VH*LSSNPMYS L*HVASDRKNNSQI*SLFLSPDEE*IGQKVDDR KEEEPE*PTVISSAVQSGSAEAHGTHTEKGNTC CLKCTIT*LSKLPFNSGIFEMKAFEPTLN*P*LR NEVGRGTFNLEEEINGRL**EKYRSRKKIIFFL *CWPRTPLHNTVLLLESIRANRVIPNSATGKTV L*PSFPGEREQLVIFKCQNFSSK*YIH*PVSSGG AKNTHHSEQYHYSISPLER*QRGRITWSQLLVF N**QGLANTPENNFTLSSQGSSSLVWAPVV*PS NVEDLMVLVCGDAGLKFNSLAKRKGRWDVLIL*W HALSSSPWSSLYI*GN*MSLFCTIQQVLSSQGY NYHEVLWNVVGGFSL

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP RGWRVILKVKKTSSGILPGTSPRSGTAWTVASL RAW*TAWPCSSGTPAGRRRTGTGTWPLPWSSCCR PTLETWRRRRPCWCWPCCWPRRWPVTRRPCSVM SFTQQ*ILLTRTYAPT*GA*PEMGWTERTVPEV *LAKARCGHSCIAASSVDGALACQQRS*RRQAGR *L*LLF*RQC*TYNPL*NIYINILE*KCPFTRI *MAFISSTHESAHL*IYTRCLYFHCAGSHLKIK LESRFQGSRNKIQFFW*KKITVY*STTIEDGLTA GSILFEESKNQRRNIPLTNEKFHSK*GLSILIL RNQQSSCLKNHMAQRF*TKVLHSNDGKSGPSTQ GLDFFNFVSFVGVKKNHLWF*KV*R*FKGPGQPL FVYKIR*LTAYTFSLSMTSRLC*RHEATGARSY CDAPGVSPLVIAVNFQFLAIRSAHPCLRSASGE NRFLSIKDERAVGLFKNSAKWFPLLGTVKTKSLR *YQNK*GKA*L*KQCNTGLLFQW*AMSQESV*K HDSGCWVHITHIAVNRKLL*PQHEATGDAYE*G H*RTHDFFLPDAFLFFKSLKSSERKNKLYIVQHA IHTTLGLAQLKVGKSLQILKRSAAAQCGGHCLE INLPNTTTFHVLEWTFKKVFQPQWKQVEPHCAY TSIHTSAIIIRFSLGEAFSSQRSCMQSSPGTNGK VFLSSK*LWTTSLTH*LFHSIFTCFCFT*IHTV GHHFITGLSVNSSRPSLR*SWL*SKTVTPSPKA NIIKRFHCLKHKCSSLEHFPAMVTRAYPGSWWIL PCNTILVDMIQR*L*FRECVFLSVLKIFELSDG NSFVKHQKLSP*KDAWCI*KSRGTFGAFRRSNH S*PLLLGPSINCCDTQGFLKGSQHWRLVLLSSNF ISCAS*ELEYRVL*MLRSCFQNLESNQLSMDLT KTIDDVK*YHLSRA*LPCG*KDESTDYLQIPCI LSSTLLLTERITHRFEVCSFPLMKSRLAKR*MTG RKRSQNDPQ*SVQQCRAAVQRLMELTRKKETHA A*NAR*LNYPNYHSIPVFLR*KHLSQH*IDLN* GMR*EEALLIWRKK*MEDCNRKNTGLGKK*FFSF DAGQGPLYIIQFSCWKASGQTELFQTLQQGRLY FDLLFLGKGNN**SLNVKTFLLNSTFINQFLLV VQRTLTTVSNTTIQFPLWRGDSGVESPGVSC*SL TDDKALQIPLRTISL*AHREAAVWCGLLWCNHQ MWKT*WC*CVGMPG*NSTALQKEREDGMC*YCS GMHFPALHGALFIYEVIECHYSVPYSRYYLAKVI ITMKCCGM**EAFHW

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP AAGG*F*KSRRHHPEYCQAPRPGRGQHGP*HPS GPGERPGPAAQEHQPVGGGPEQGPGHCPGAAAA GLP*RHGEGEDHAGAGPAAGQEGGQSHAVLAP*C LSHNSEFY*PEPTHLREELSQKWDGLNGQFQKC DWLKLDVVTAV*LLPV*TEPWHVNSVPREDRLE DSCDFYFKDNVKLITHFKISTLIYLNENVHLHVF EWPSYHPHMNLHICKSTHGAFISTVQVPT*KLN WKAGFKEVETKYNFFGKKKLLFIKVQP*RMVLQ QAVSCLRKARIREGTYPLQMKNSTQNRDYLS*Y* GTNNLPV*KTTWHRDSELKCCTQMMGSPAPVHR GLTFSTSFPLLESKRTTCGSKRCEGDLRAQVSH CLFTKSGN*LHTLFLFP*HQDFAKDMKPRVPEAT AMPRELAPW**L*TSNF*PYAQLIHASEVHLER TGF*A*KMKEQLDFLKIQQSGSLS*GQSKPSHL GSTKINKEKLSFRNSATLVCCSSGKLCPRNQFKS TTVDAGSISHTLL*TGNSCDHNMRPLETHMSKG TDGLMISSYQMLSCSLRV*NHQKGKTNSILFSM QYIPR*GWLN*KWAKAYKY*KEVLPRSVEATVWK *IFLTLRLFMFWSGLLKKFSNHNGNRLNHTAPT HPSIRQPL*SDSHWGRHFLPKGAVCSHHPELMG KCS*AASDSGPPLSHTDSSTASSPASVSLEFIQ* ATIL*QVLV*ILPDQV*DSLGCKARPSPLLPKP TL*KDSIVSNTNVPVLSTSQPW*LGHILAVGGF CPVTQSLWI*FKGDFNSENVFSFLF*KYLN*VME ILLLNIKSFLLEKMLGVSESHVGHLVHSEGQII PDLSS*DPALTAAILKASLKDHSTGA*FYCPAT LLVVLAENWNIESFECYDLVFKTWSQTN*VWT*Q RQLMM*NDTTCQGHSYHVDRKMSPLIIFKSHVF SLARCF*QKE*LTDLKFVPFP**RVDWPKGR*Q EGRGARMTHSDQFSSAERQCRGSWNSHGKRKHML LKMHDNLIIQITIQFRYF*DESI*ANTKLTLIK E*GRKRHF*SGGRNKWKTVIGKIQV*EKNNFFP LMLAKDPST*YSSPAGKHQGKQSYSKLCNREDCT LTFFSWGKGTTSNL*MSKLFF*IVHSLTSFFWW CKEHSPQ*AIPLFNFPFGEVTAG*NHLESAASL *LMTRPCKYP*EQFHSELTGKQQSGVGSCGVTIK CGRPDGVSVWGCRAEIQQPCKKKGKMGCVNIVV ACTFQLSMELSLYMR*LNVTILYHTAGII*PRL *LP*SAVECSRRLFTG

Sequence BID.cAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC CGCGGCTGGAGGGTGGTCGCCACTGGGACACTGTGAACCAGGAGTGAGTCGGAGCTGCCGCGCTGCCCAGGCCATGGACTGTGAGGTCAACAACGGTTCC AGCCTCAGGGATGAGTGCATCACAAACCTACTGGTGTTTGGCTTCCTCCAAAGCTGTTCTGACAACAGCTTCCGCAGAGAGCTGGACGCACTGGGCCACG AGCTGCCAGTGCTGGCTCCCCAGTGGGAGGGCTACGATGAGCTGCAGACTGATGGCAACCGCAGCAGCCACTCCCGCTTGGGAAGAATAGAGGCAGATTC TGAAAGTCAAGAAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTGAACGGCCTG GCCCTGCAGCTCAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGG AGAAGGAGAAGACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACAACAGTGAA TTTTATTAACCAGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGATG TGGTCACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTGTGACTTCTATTT TAAAGACAATGTTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATATCACACACATTGCTGTGAACAGGAAACTC CTGTGACCACAACATGAGGCCACTGGAGACGCATATGAGTAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTT TAAAATCATCAGAAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAAT ACTAAAAAGAAGTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAAATAAATCTTCCTAACACTACGACTTTTCATGTTTTGGAGTGGACTTTTAAAAAA GTTTTCCAACCACAATGGAAACAGGTTGAACCACACTGCGCCTACACATCCATCCATACGTCAGCCATTATAATCAGATTCTCACTGGGGGAGGCATTTT CTTCCCAAAGGAGCTGTATGCAGTCATCACCCGGAACTAATGGGAAAGTGTTCTTAAGCAGCAAGTGACTCTGGACCACCTCTCTCACACACTGACTCTT CCACAGCATCTTCACCTGCTTCTGTTTCACTTGAATTCATACAGTAGGCCACCATTTTATAACAGGTCTTAGTGTAAATTCTTCCAGACCAAGTCTGAGA TAGTCTTGGTTGTAAAGCAAGACCGTCACCCCTTCTCCCAAAGCCAACATTATAAAAAGATTCCATTGTCTCAAACACAAATGTTCCAGTCTTGAGCACT TCCCAGCCATGGTGACTCGGGCATATCCTGGCAGTTGGTGGATTTTGCCCTGTAACACAATCCTTGTGGATATGATTCAAAGGTGACTTTAATTCAGAGA ATGTGTTTTCCTTTCTGTTTTAAAAATATTTGAATTAAGTGATGGAAATTCTTTTGTTAAACATCAAAAGCTTTCTCCTTGAAAAGATGCTTGGTGTATC TGAAAGTCACGTGGGACATTTGGTGCATTCAGAAGGTCAAATCATTCCTGACCTCTCCTCTTAGGACCCAGCATTAACTGCTGCGATACTCAAGGCTTCC TTAAAGGATCACAGCACTGGCGCCTAGTTTTACTGTCCAGCAACTTTATTAGTTGTGCTAGCTGAGAATTGGAATATAGAGTCCTTTGAATGTTACGATC TTGTTTTCAAAACCTGGAGTCAAACCAATTAAGTATGGACTTAACAAAGACAATTGATGATGTGAAATGATACCACCTGTCAAGGGCATAGTTACCATGT GGATAGAAAGATGAGTCCACTGATTATCTTCAAATCCCATGTATTCTCTCTAGCACGTTGCTTCTGACAGAAAGAATAACTCACAGATTTGAAGTTTGTT CCTTTCCCCTGATGAAGAGTAGATTGGCCAAAAGGTAGATGACAGGAAGGAAGAGGAGCCAGAATGACCCACAGTGATCAGTTCAGCAGTGCAGAGCGGC AGTGCAGAGGCTCATGGAACTCACACGGAAAAAGGAAACACATGCTGCTTAAAATGCACGATAACTTAATTATCCAAATTACCATTCAATTCCGGTATTT TTGAGATGAAAGCATTTGAGCCAACACTAAATTGACCTTAATTAAGGAATGAGGTAGGAAGAGGCACTTTTAATCTGGAGGAAGAAATAAATGGAAGACT GTAATAGGAAAAATACAGGTCTAGGAAAAAAATAATTTTTTTCCTTTGATGCTGGCCAAGGACCCCTCTACATAATACAGTTCTCCTGCTGGAAAGCATC AGGGCAAACAGAGTTATTCCAAACTCTGCAACAGGGAAGACTGTACTTTGACCTTCTTTTCCTGGGGAAAGGGAACAACTAGTAATCTTTAAATGTCAAA ACTTTTCTTCTAAATAGTACATTCATTAACCAGTTTCTTCTGGTGGTGCAAAGAACACTCACCACAGTGAGCAATACCACTATTCAATTTCCCCTTTGGA GAGGTGACAGCGGGGTAGAATCACCTGGAGTCAGCTGCTAGTCTTTAACTGATGACAAGGCCTTGCAAATACCCCTGAGAACAATTTCACTCTGAGCTCA CAGGGAAGCAGCAGTCTGGTGTGGGCTCCTGTGGTGTAACCATCAAATGTGGAAGACCTGATGGTGTTAGTGTGTGGGGATGCCGGGCTGAAATTCAACA GCCTTGCAAAAAGAAAGGGAAGATGGGATGTGTTAATATTGTAGTGGCATGCACTTTCCAGCTCTCCATGGAGCTCTCTTTATATATGAGGTAATTGAAT GTCACTATTCTGTACCATACAGCAGGTATTATCTAGCCAAGGTTATAATTACCATGAAGTGCTGTGGAATGTAGTAGGAGGCTTTTCACTGGG

BID.u.f.10 (forward primer)
BID.u.r.14 (reverse primer)
Multiple exon skipping

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP PRLEGGRHWDTVNQE*VGAAALPRPWTVRSTTVP ASGMSASQTYWCLASSKAVLTTASAESWTHWAT SCQCWLPSGRATMSCRLMATAAATPAWEE*RQI LKVKKTSSGILPGTSPRSGTAWTVASLRAW*TAW PCSSGTPAGRRRTGTGTWPLPWSSCCRPTLETW RRRRPCWCWPCCWPRRWPVTRRPCSVMSFTQQ* ILLTRTYAPT*GA*PEMGWTERTVPEV*LAKARC GHSCIAASSVDGALACQQRS*RRQAGR*L*LLF *RQC*TYNPL*NIYINILE*KCPYHTHCCEQET PVTTT*GHWRRI*VRALTDS*FLLTRCFPVL*EF KIIRKEKQTLYCSACNTYHARAGSIESGQKLTN TKKKCCRAVWRPLFGNKSS*HYDFSCFGVDF*K SFPTTMETG*TTLRLHIHPYVSHYNQILTGGGIF FPKELYAVITRN*WESVLKQQVTLDHLSHTLTL PQHLHLLLFHLNSYSRPPFYNRS*CKFFQTKSE IVLVVKQDRHPFSQSQHYKKIPLSQTQMFQS*AL PSHGDSGISWQLVDFAL*HNPCGYDSKVTLIQR MCFPFCFKNI*IK*WKFFC*TSKAFSLKRCLVY LKVTWDIWCIQKVKSFLTSPLRTQH*LLRYSRLP *RITALAPSFTVQQLY*LC*LRIGI*SPLNVTI LFSKPGVKPIKYGLNKDN**CEMIPPVKGIVTM WIER*VH*LSSNPMYSL*HVASDRKNNSQI*SLF LSPDEE*IGQKVDDRKEEEPE*PTVISSAVQSG SAEAHGTHTEKGNTCCLKCTIT*LSKLPFNSGI FEMKAFEPTLN*P*LRNEVGRGTFNLEEEINGRL **EKYRSRKKIIFFL*CWPRTPLHNTVLLLESI RANRVIPNSATGKTVL*PSFPGEREQLVIFKCQ NFSSK*YIH*PVSSGGAKNTHHSEQYHYSISPLE R*QRGRITWSQLLVFN**QGLANTPENNFTLSS QGSSSLVWAPVV*PSNVEDLMVLVCGDAGLKFN SLAKRKGRWDVLIL*WHALSSSPWSSLYI*GN*M SLFCTIQQVLSSQGYNYHEVLWNVVGGFSL

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP RGWRVVATGTL*TRSESELPRCPGHGL*GQQRF QPQG*VHHKPTGVWLPPKLF*QQLPQRAGRTGPR AASAGSPVGGLR*AAD*WQPQQPLPLGKNRGRF *KSRRHHPEYCQAPRPGRGQHGP*HPSGPGERP GPAAQEHQPVGGGPEQGPGHCPGAAAAGLP*RHG EGEDHAGAGPAAGQEGGQSHAVLAP*CLSHNSE FY*PEPTHLREELSQKWDGLNGQFQKCDWLKLD VVTAV*LLPV*TEPWHVNSVPREDRLEDSCDFYF KDNVKLITHFKISTLIYLNENVHITHIAVNRKL L*PQHEATGDAYE*GH*RTHDFFLPDAFLFFKS LKSSERKNKLYIVQHAIHTTLGLAQLKVGKSLQI LKRSAAAQCGGHCLEINLPNTTTFHVLEWTFKK VFQPQWKQVEPHCAYTSIHTSAIIIRFSLGEAF SSQRSCMQSSPGTNGKVFLSSK*LWTTSLTH*LF HSIFTCFCFT*IHTVGHHFITGLSVNSSRPSLR *SWL*SKTVTPSPKANIIKRFHCLKHKCSSLEH FPAMVTRAYPGSWWILPCNTILVDMIQR*L*FRE CVFLSVLKIFELSDGNSFVKHQKLSP*KDAWCI *KSRGTFGAFRRSNHS*PLLLGPSINCCDTQGF LKGSQHWRLVLLSSNFISCAS*ELEYRVL*MLRS CFQNLESNQLSMDLTKTIDDVK*YHLSRA*LPC G*KDESTDYLQIPCILSSTLLLTERITHRFEVC SFPLMKSRLAKR*MTGRKRSQNDPQ*SVQQCRAA VQRLMELTRKKETHAA*NAR*LNYPNYHSIPVF LR*KHLSQH*IDLN*GMR*EEALLIWRKK*MED CNRKNTGLGKK*FFSFDAGQGPLYIIQFSCWKAS GQTELFQTLQQGRLYFDLLFLGKGNN**SLNVK TFLLNSTFINQFLLVVQRTLTTVSNTTIQFPLW RGDSGVESPGVSC*SLTDDKALQIPLRTISL*AH REAAVWCGLLWCNHQMWKT*WC*CVGMPG*NST ALQKEREDGMC*YCSGMHFPALHGALFIYEVIE CHYSVPYSRYYLAKVIITMKCCGM**EAFHW

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP AAGGWSPLGHCEPGVSRSCRAAQAMDCEVNNGS SLRDECITNLLVFGFLQSCSDNSFRRELDALGH ELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADS ESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGL ALQLRNTSRSEEDRNRDLATALEQLLQAYPRDM EKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVN FINQNLRTYVRSLARNGMD*TDSSRSVTG*SSM WSQLYSCFQCRRSPGMSTAFLEKTGWKIAVTSI LKTMLNL*PTLKYLH*YT*MKMSISHTLL*TGNS CDHNMRPLETHMSKGTDGLMISSYQMLSCSLRV *NHQKGKTNSILFSMQYIPR*GWLN*KWAKAYK Y*KEVLPRSVEATVWK*IFLTLRLFMFWSGLLKK FSNHNGNRLNHTAPTHPSIRQPL*SDSHWGRHF LPKGAVCSHHPELMGKCS*AASDSGPPLSHTDS STASSPASVSLEFIQ*ATIL*QVLV*ILPDQV*D SLGCKARPSPLLPKPTL*KDSIVSNTNVPVLST SQPW*LGHILAVGGFCPVTQSLWI*FKGDFNSE NVFSFLF*KYLN*VMEILLLNIKSFLLEKMLGVS ESHVGHLVHSEGQIIPDLSS*DPALTAAILKAS LKDHSTGA*FYCPATLLVVLAENWNIESFECYD LVFKTWSQTN*VWT*QRQLMM*NDTTCQGHSYHV DRKMSPLIIFKSHVFSLARCF*QKE*LTDLKFV PFP**RVDWPKGR*QEGRGARMTHSDQFSSAER QCRGSWNSHGKRKHMLLKMHDNLIIQITIQFRYF *DESI*ANTKLTLIKE*GRKRHF*SGGRNKWKT VIGKIQV*EKNNFFPLMLAKDPST*YSSPAGKH QGKQSYSKLCNREDCTLTFFSWGKGTTSNL*MSK LFF*IVHSLTSFFWWCKEHSPQ*AIPLFNFPFG EVTAG*NHLESAASL*LMTRPCKYP*EQFHSEL TGKQQSGVGSCGVTIKCGRPDGVSVWGCRAEIQQ PCKKKGKMGCVNIVVACTFQLSMELSLYMR*LN VTILYHTAGII*PRL*LP*SAVECSRRLFTG

Sequence BID.bAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC CGCGGCTGGAGGGTGGTCGCCACTGGGACACTGTGAACCAGGAGTGAGTCGGAGCTGCCGCGCTGCCCAGGCCATGGACTGTGAGGTCAACAACGGTTCC AGCCTCAGGGATGAGTGCATCACAAACCTACTGGTGTTTGGCTTCCTCCAAAGCTGTTCTGACAACAGCTTCCGCAGAGAGCTGGACGCACTGGGCCACG AGCTGCCAGTGCTGGCTCCCCAGTGGGAGGGCTACGATGAGCTGCAGACTGATGGCAACCGCAGCAGCCACTCCCGCTTGGGAAGAATAGAGGCAGATTC TGAAAGTCAAGAAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTGAACGGCCTG GCCCTGCAGCTCAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGG AGAAGGAGAAGACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACAACAGTGAA TTTTATTAACCAGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGATG TGGTCACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTGTGACTTCTATTT TAAAGACAATGTTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATTTACACGTATTTGAATGGCCTTCATATCAT CCACACATGAATCTGCACATCTGTAAATCTACACACGGTGCCTTTATTTCCACTGTGCAGGTTCCCACTTAAAAATTAAATTGGAAAGCAGGTTTCAAGG AAGTAGAAACAAAATACAATTTTTTTGGTAAAAAAAAATTACTGTTTATTAAAGTACAACCATAGAGGATGGTCTTACAGCAGGCAGTATCCTGTTTGAG GAAAGCAAGAATCAGAGAAGGAACATACCCCTTACAAATGAAAAATTCCACTCAAAATAGGGACTATCTATCTTAATACTAAGGAACCAACAATCTTCCT GTTTAAAAAACCACATGGCACAGAGATTCTGAACTAAAGTGCTGCACTCAAATGATGGGAAGTCCGGCCCCAGTACACAGGGGCTTGACTTTTTCAACTT CGTTTCCTTTGTTGGAGTCAAAAAGAACCACTTGTGGTTCTAAAAGGTGTGAAGGTGATTTAAGGGCCCAGGTCAGCCACTGTTTGTTTACAAAATCAGG TAACTAACTGCATACACTTTTTCTCTTTCCATGACATCAAGACTTTGCTAAAGACATGAAGCCACGGGTGCCAGAAGCTACTGCGATGCCCCGGGAGTTA GCCCCCTGGTAATAGCTGTAAACTTCCAATTTCTAGCCATACGCTCAGCTCATCCATGCCTCAGAAGTGCATCTGGAGAGAACAGGTTTCTAAGCATAAA AGATGAAAGAGCAGTTGGACTTTTTAAAAATTCAGCAAAGTGGTTCCCTCTCTTAGGGACAGTCAAAACCAAGTCACTTAGGTAGTACCAAAATAAATAA GGAAAAGCTTAGCTTTAGAAACAGTGCAACACTGGTCTGCTGTTCCAGTGGTAAGCTATGTCCCAGGAATCAGTTTAAAAGCACGACAGTGGATGCTGGG TCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACAACATGAGGCCACTGGAGACGCATATGAGTAAGGGCACTGACGGACTCATGATTT CTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCAGAAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGG CTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAAGTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAAATAAATCTTCCTAACACTA CGACTTTTCATGTTTTGGAGTGGACTTTTAAAAAAGTTTTCCAACCACAATGGAAACAGGTTGAACCACACTGCGCCTACACATCCATCCATACGTCAGC CATTATAATCAGATTCTCACTGGGGGAGGCATTTTCTTCCCAAAGGAGCTGTATGCAGTCATCACCCGGAACTAATGGGAAAGTGTTCTTAAGCAGCAAG TGACTCTGGACCACCTCTCTCACACACTGACTCTTCCACAGCATCTTCACCTGCTTCTGTTTCACTTGAATTCATACAGTAGGCCACCATTTTATAACAG GTCTTAGTGTAAATTCTTCCAGACCAAGTCTGAGATAGTCTTGGTTGTAAAGCAAGACCGTCACCCCTTCTCCCAAAGCCAACATTATAAAAAGATTCCA TTGTCTCAAACACAAATGTTCCAGTCTTGAGCACTTCCCAGCCATGGTGACTCGGGCATATCCTGGCAGTTGGTGGATTTTGCCCTGTAACACAATCCTT GTGGATATGATTCAAAGGTGACTTTAATTCAGAGAATGTGTTTTCCTTTCTGTTTTAAAAATATTTGAATTAAGTGATGGAAATTCTTTTGTTAAACATC AAAAGCTTTCTCCTTGAAAAGATGCTTGGTGTATCTGAAAGTCACGTGGGACATTTGGTGCATTCAGAAGGTCAAATCATTCCTGACCTCTCCTCTTAGG ACCCAGCATTAACTGCTGCGATACTCAAGGCTTCCTTAAAGGATCACAGCACTGGCGCCTAGTTTTACTGTCCAGCAACTTTATTAGTTGTGCTAGCTGA GAATTGGAATATAGAGTCCTTTGAATGTTACGATCTTGTTTTCAAAACCTGGAGTCAAACCAATTAAGTATGGACTTAACAAAGACAATTGATGATGTGA AATGATACCACCTGTCAAGGGCATAGTTACCATGTGGATAGAAAGATGAGTCCACTGATTATCTTCAAATCCCATGTATTCTCTCTAGCACGTTGCTTCT GACAGAAAGAATAACTCACAGATTTGAAGTTTGTTCCTTTCCCCTGATGAAGAGTAGATTGGCCAAAAGGTAGATGACAGGAAGGAAGAGGAGCCAGAAT GACCCACAGTGATCAGTTCAGCAGTGCAGAGCGGCAGTGCAGAGGCTCATGGAACTCACACGGAAAAAGGAAACACATGCTGCTTAAAATGCACGATAAC TTAATTATCCAAATTACCATTCAATTCCGGTATTTTTGAGATGAAAGCATTTGAGCCAACACTAAATTGACCTTAATTAAGGAATGAGGTAGGAAGAGGC ACTTTTAATCTGGAGGAAGAAATAAATGGAAGACTGTAATAGGAAAAATACAGGTCTAGGAAAAAAATAATTTTTTTCCTTTGATGCTGGCCAAGGACCC CTCTACATAATACAGTTCTCCTGCTGGAAAGCATCAGGGCAAACAGAGTTATTCCAAACTCTGCAACAGGGAAGACTGTACTTTGACCTTCTTTTCCTGG GGAAAGGGAACAACTAGTAATCTTTAAATGTCAAAACTTTTCTTCTAAATAGTACATTCATTAACCAGTTTCTTCTGGTGGTGCAAAGAACACTCACCAC AGTGAGCAATACCACTATTCAATTTCCCCTTTGGAGAGGTGACAGCGGGGTAGAATCACCTGGAGTCAGCTGCTAGTCTTTAACTGATGACAAGGCCTTG CAAATACCCCTGAGAACAATTTCACTCTGAGCTCACAGGGAAGCAGCAGTCTGGTGTGGGCTCCTGTGGTGTAACCATCAAATGTGGAAGACCTGATGGT GTTAGTGTGTGGGGATGCCGGGCTGAAATTCAACAGCCTTGCAAAAAGAAAGGGAAGATGGGATGTGTTAATATTGTAGTGGCATGCACTTTCCAGCTCT CCATGGAGCTCTCTTTATATATGAGGTAATTGAATGTCACTATTCTGTACCATACAGCAGGTATTATCTAGCCAAGGTTATAATTACCATGAAGTGCTGT GGAATGTAGTAGGAGGCTTTTCACTGGG

BID.u.f.10 (forward primer)
BID.u.r.14 (reverse primer)
Multiple exon skipping

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP PRLEGGRHWDTVNQE*VGAAALPRPWTVRSTTVP ASGMSASQTYWCLASSKAVLTTASAESWTHWAT SCQCWLPSGRATMSCRLMATAAATPAWEE*RQI LKVKKTSSGILPGTSPRSGTAWTVASLRAW*TAW PCSSGTPAGRRRTGTGTWPLPWSSCCRPTLETW RRRRPCWCWPCCWPRRWPVTRRPCSVMSFTQQ* ILLTRTYAPT*GA*PEMGWTERTVPEV*LAKARC GHSCIAASSVDGALACQQRS*RRQAGR*L*LLF *RQC*TYNPL*NIYINILE*KCPFTRI*MAFIS STHESAHL*IYTRCLYFHCAGSHLKIKLESRFQG SRNKIQFFW*KKITVY*STTIEDGLTAGSILFE ESKNQRRNIPLTNEKFHSK*GLSILILRNQQSS CLKNHMAQRF*TKVLHSNDGKSGPSTQGLDFFNF VSFVGVKKNHLWF*KV*R*FKGPGQPLFVYKIR *LTAYTFSLSMTSRLC*RHEATGARSYCDAPGV SPLVIAVNFQFLAIRSAHPCLRSASGENRFLSIK DERAVGLFKNSAKWFPLLGTVKTKSLR*YQNK* GKA*L*KQCNTGLLFQW*AMSQESV*KHDSGCW VHITHIAVNRKLL*PQHEATGDAYE*GH*RTHDF FLPDAFLFFKSLKSSERKNKLYIVQHAIHTTLG LAQLKVGKSLQILKRSAAAQCGGHCLEINLPNT TTFHVLEWTFKKVFQPQWKQVEPHCAYTSIHTSA IIIRFSLGEAFSSQRSCMQSSPGTNGKVFLSSK *LWTTSLTH*LFHSIFTCFCFT*IHTVGHHFIT GLSVNSSRPSLR*SWL*SKTVTPSPKANIIKRFH CLKHKCSSLEHFPAMVTRAYPGSWWILPCNTIL VDMIQR*L*FRECVFLSVLKIFELSDGNSFVKH QKLSP*KDAWCI*KSRGTFGAFRRSNHS*PLLLG PSINCCDTQGFLKGSQHWRLVLLSSNFISCAS* ELEYRVL*MLRSCFQNLESNQLSMDLTKTIDDV K*YHLSRA*LPCG*KDESTDYLQIPCILSSTLLL TERITHRFEVCSFPLMKSRLAKR*MTGRKRSQN DPQ*SVQQCRAAVQRLMELTRKKETHAA*NAR* LNYPNYHSIPVFLR*KHLSQH*IDLN*GMR*EEA LLIWRKK*MEDCNRKNTGLGKK*FFSFDAGQGP LYIIQFSCWKASGQTELFQTLQQGRLYFDLLFL GKGNN**SLNVKTFLLNSTFINQFLLVVQRTLTT VSNTTIQFPLWRGDSGVESPGVSC*SLTDDKAL QIPLRTISL*AHREAAVWCGLLWCNHQMWKT*W C*CVGMPG*NSTALQKEREDGMC*YCSGMHFPAL HGALFIYEVIECHYSVPYSRYYLAKVIITMKCC GM**EAFHW

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP RGWRVVATGTL*TRSESELPRCPGHGL*GQQRF QPQG*VHHKPTGVWLPPKLF*QQLPQRAGRTGPR AASAGSPVGGLR*AAD*WQPQQPLPLGKNRGRF *KSRRHHPEYCQAPRPGRGQHGP*HPSGPGERP GPAAQEHQPVGGGPEQGPGHCPGAAAAGLP*RHG EGEDHAGAGPAAGQEGGQSHAVLAP*CLSHNSE FY*PEPTHLREELSQKWDGLNGQFQKCDWLKLD VVTAV*LLPV*TEPWHVNSVPREDRLEDSCDFYF KDNVKLITHFKISTLIYLNENVHLHVFEWPSYH PHMNLHICKSTHGAFISTVQVPT*KLNWKAGFK EVETKYNFFGKKKLLFIKVQP*RMVLQQAVSCLR KARIREGTYPLQMKNSTQNRDYLS*Y*GTNNLP V*KTTWHRDSELKCCTQMMGSPAPVHRGLTFST SFPLLESKRTTCGSKRCEGDLRAQVSHCLFTKSG N*LHTLFLFP*HQDFAKDMKPRVPEATAMPREL APW**L*TSNF*PYAQLIHASEVHLERTGF*A* KMKEQLDFLKIQQSGSLS*GQSKPSHLGSTKINK EKLSFRNSATLVCCSSGKLCPRNQFKSTTVDAG SISHTLL*TGNSCDHNMRPLETHMSKGTDGLMI SSYQMLSCSLRV*NHQKGKTNSILFSMQYIPR*G WLN*KWAKAYKY*KEVLPRSVEATVWK*IFLTL RLFMFWSGLLKKFSNHNGNRLNHTAPTHPSIRQ PL*SDSHWGRHFLPKGAVCSHHPELMGKCS*AAS DSGPPLSHTDSSTASSPASVSLEFIQ*ATIL*Q VLV*ILPDQV*DSLGCKARPSPLLPKPTL*KDS IVSNTNVPVLSTSQPW*LGHILAVGGFCPVTQSL WI*FKGDFNSENVFSFLF*KYLN*VMEILLLNI KSFLLEKMLGVSESHVGHLVHSEGQIIPDLSS* DPALTAAILKASLKDHSTGA*FYCPATLLVVLAE NWNIESFECYDLVFKTWSQTN*VWT*QRQLMM* NDTTCQGHSYHVDRKMSPLIIFKSHVFSLARCF *QKE*LTDLKFVPFP**RVDWPKGR*QEGRGARM THSDQFSSAERQCRGSWNSHGKRKHMLLKMHDN LIIQITIQFRYF*DESI*ANTKLTLIKE*GRKR HF*SGGRNKWKTVIGKIQV*EKNNFFPLMLAKDP ST*YSSPAGKHQGKQSYSKLCNREDCTLTFFSW GKGTTSNL*MSKLFF*IVHSLTSFFWWCKEHSP Q*AIPLFNFPFGEVTAG*NHLESAASL*LMTRPC KYP*EQFHSELTGKQQSGVGSCGVTIKCGRPDG VSVWGCRAEIQQPCKKKGKMGCVNIVVACTFQL SMELSLYMR*LNVTILYHTAGII*PRL*LP*SAV ECSRRLFTG

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP AAGGWSPLGHCEPGVSRSCRAAQAMDCEVNNGS SLRDECITNLLVFGFLQSCSDNSFRRELDALGH ELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADS ESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGL ALQLRNTSRSEEDRNRDLATALEQLLQAYPRDM EKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVN FINQNLRTYVRSLARNGMD*TDSSRSVTG*SSM WSQLYSCFQCRRSPGMSTAFLEKTGWKIAVTSI LKTMLNL*PTLKYLH*YT*MKMSIYTYLNGLHII HT*ICTSVNLHTVPLFPLCRFPLKN*IGKQVSR K*KQNTIFLVKKNYCLLKYNHRGWSYSRQYPV* GKQESEKEHTPYK*KIPLKIGTIYLNTKEPTIFL FKKPHGTEILN*SAALK*WEVRPQYTGA*LFQL RFLCWSQKEPLVVLKGVKVI*GPRSATVCLQNQ VTNCIHFFSFHDIKTLLKT*SHGCQKLLRCPGS* PPGNSCKLPISSHTLSSSMPQKCIWREQVSKHK R*KSSWTF*KFSKVVPSLRDSQNQVT*VVPK*I RKSLALETVQHWSAVPVVSYVPGISLKARQWMLG PYHTHCCEQETPVTTT*GHWRRI*VRALTDS*F LLTRCFPVL*EFKIIRKEKQTLYCSACNTYHAR AGSIESGQKLTNTKKKCCRAVWRPLFGNKSS*HY DFSCFGVDF*KSFPTTMETG*TTLRLHIHPYVS HYNQILTGGGIFFPKELYAVITRN*WESVLKQQ VTLDHLSHTLTLPQHLHLLLFHLNSYSRPPFYNR S*CKFFQTKSEIVLVVKQDRHPFSQSQHYKKIP LSQTQMFQS*ALPSHGDSGISWQLVDFAL*HNP CGYDSKVTLIQRMCFPFCFKNI*IK*WKFFC*TS KAFSLKRCLVYLKVTWDIWCIQKVKSFLTSPLR TQH*LLRYSRLP*RITALAPSFTVQQLY*LC*L RIGI*SPLNVTILFSKPGVKPIKYGLNKDN**CE MIPPVKGIVTMWIER*VH*LSSNPMYSL*HVAS DRKNNSQI*SLFLSPDEE*IGQKVDDRKEEEPE *PTVISSAVQSGSAEAHGTHTEKGNTCCLKCTIT *LSKLPFNSGIFEMKAFEPTLN*P*LRNEVGRG TFNLEEEINGRL**EKYRSRKKIIFFL*CWPRT PLHNTVLLLESIRANRVIPNSATGKTVL*PSFPG EREQLVIFKCQNFSSK*YIH*PVSSGGAKNTHH SEQYHYSISPLER*QRGRITWSQLLVFN**QGL ANTPENNFTLSSQGSSSLVWAPVV*PSNVEDLMV LVCGDAGLKFNSLAKRKGRWDVLIL*WHALSSS PWSSLYI*GN*MSLFCTIQQVLSSQGYNYHEVL WNVVGGFSL