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Sequences

Sequence BID.hAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC CGCGGCTGGAGGGTGATTCTGAAAGTCAAGAAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCC GGGCCTGGTGAACGGCCTGGCCCTGCAGCTCAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAG GCCTACCCTAGAGACATGGAGAAGGAGAAGACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATG TCTTTCACACAACAGTGAATTTTATTAACCAGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGT GACTGGCTAAAGCTCGATGTGGTCACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAG ATAGCTGTGACTTCTATTTTAAAGACAATGTTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATTTACACGTATT TGAATGGCCTTCATATCATCCACACATGAATCTGCACATCTGTAAATCTACACACGGTGCCTTTATTTCCACTGTGCAGGTTCCCACTTAAAAATTAAAT TGGAAAGCAGGTTTCAAGGAAGTAGAAACAAAATACAATTTTTTTGGTAAAAAAAAATTACTGTTTATTAAAGTACAACCATAGAGGATGGTCTTACAGC AGGCAGTATCCTGTTTGAGGAAAGCAAGAATCAGAGAAGGAACATACCCCTTACAAATGAAAAATTCCACTCAAAATAGGGACTATCTATCTTAATACTA AGGAACCAACAATCTTCCTGTTTAAAAAACCACATGGCACAGAGATTCTGAACTAAAGTGCTGCACTCAAATGATGGGAAGTCCGGCCCCAGTACACAGG GGCTTGACTTTTTCAACTTCGTTTCCTTTGTTGGAGTCAAAAAGAACCACTTGTGGTTCTAAAAGGTGTGAAGGTGATTTAAGGGCCCAGGTCAGCCACT GTTTGTTTACAAAATCAGGTAACTAACTGCATACACTTTTTCTCTTTCCATGACATCAAGACTTTGCTAAAGACATGAAGCCACGGGTGCCAGAAGCTAC TGCGATGCCCCGGGAGTTAGCCCCCTGGTAATAGCTGTAAACTTCCAATTTCTAGCCATACGCTCAGCTCATCCATGCCTCAGAAGTGCATCTGGAGAGA ACAGGTTTCTAAGCATAAAAGATGAAAGAGCAGTTGGACTTTTTAAAAATTCAGCAAAGTGGTTCCCTCTCTTAGGGACAGTCAAAACCAAGTCACTTAG GTAGTACCAAAATAAATAAGGAAAAGCTTAGCTTTAGAAACAGTGCAACACTGGTCTGCTGTTCCAGTGGTAAGCTATGTCCCAGGAATCAGTTTAAAAG CACGACAGTGGATGCTGGGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACAACATGAGGCCACTGGAGACGCATATGAGTAAGGGC ACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCAGAAAGGAAAAACAAACTCTATATTGTTCAGCATGC AATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAAGTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAA ATAAATCTTCCTAACACTACGACTTTTCATGTTTTGGAGTGGACTTTTAAAAAAGTTTTCCAACCACAATGGAAACAGGTTGAACCACACTGCGCCTACA CATCCATCCATACGTCAGCCATTATAATCAGATTCTCACTGGGGGAGGCATTTTCTTCCCAAAGGAGCTGTATGCAGTCATCACCCGGAACTAATGGGAA AGTGTTCTTAAGCAGCAAGTGACTCTGGACCACCTCTCTCACACACTGACTCTTCCACAGCATCTTCACCTGCTTCTGTTTCACTTGAATTCATACAGTA GGCCACCATTTTATAACAGGTCTTAGTGTAAATTCTTCCAGACCAAGTCTGAGATAGTCTTGGTTGTAAAGCAAGACCGTCACCCCTTCTCCCAAAGCCA ACATTATAAAAAGATTCCATTGTCTCAAACACAAATGTTCCAGTCTTGAGCACTTCCCAGCCATGGTGACTCGGGCATATCCTGGCAGTTGGTGGATTTT GCCCTGTAACACAATCCTTGTGGATATGATTCAAAGGTGACTTTAATTCAGAGAATGTGTTTTCCTTTCTGTTTTAAAAATATTTGAATTAAGTGATGGA AATTCTTTTGTTAAACATCAAAAGCTTTCTCCTTGAAAAGATGCTTGGTGTATCTGAAAGTCACGTGGGACATTTGGTGCATTCAGAAGGTCAAATCATT CCTGACCTCTCCTCTTAGGACCCAGCATTAACTGCTGCGATACTCAAGGCTTCCTTAAAGGATCACAGCACTGGCGCCTAGTTTTACTGTCCAGCAACTT TATTAGTTGTGCTAGCTGAGAATTGGAATATAGAGTCCTTTGAATGTTACGATCTTGTTTTCAAAACCTGGAGTCAAACCAATTAAGTATGGACTTAACA AAGACAATTGATGATGTGAAATGATACCACCTGTCAAGGGCATAGTTACCATGTGGATAGAAAGATGAGTCCACTGATTATCTTCAAATCCCATGTATTC TCTCTAGCACGTTGCTTCTGACAGAAAGAATAACTCACAGATTTGAAGTTTGTTCCTTTCCCCTGATGAAGAGTAGATTGGCCAAAAGGTAGATGACAGG AAGGAAGAGGAGCCAGAATGACCCACAGTGATCAGTTCAGCAGTGCAGAGCGGCAGTGCAGAGGCTCATGGAACTCACACGGAAAAAGGAAACACATGCT GCTTAAAATGCACGATAACTTAATTATCCAAATTACCATTCAATTCCGGTATTTTTGAGATGAAAGCATTTGAGCCAACACTAAATTGACCTTAATTAAG GAATGAGGTAGGAAGAGGCACTTTTAATCTGGAGGAAGAAATAAATGGAAGACTGTAATAGGAAAAATACAGGTCTAGGAAAAAAATAATTTTTTTCCTT TGATGCTGGCCAAGGACCCCTCTACATAATACAGTTCTCCTGCTGGAAAGCATCAGGGCAAACAGAGTTATTCCAAACTCTGCAACAGGGAAGACTGTAC TTTGACCTTCTTTTCCTGGGGAAAGGGAACAACTAGTAATCTTTAAATGTCAAAACTTTTCTTCTAAATAGTACATTCATTAACCAGTTTCTTCTGGTGG TGCAAAGAACACTCACCACAGTGAGCAATACCACTATTCAATTTCCCCTTTGGAGAGGTGACAGCGGGGTAGAATCACCTGGAGTCAGCTGCTAGTCTTT AACTGATGACAAGGCCTTGCAAATACCCCTGAGAACAATTTCACTCTGAGCTCACAGGGAAGCAGCAGTCTGGTGTGGGCTCCTGTGGTGTAACCATCAA ATGTGGAAGACCTGATGGTGTTAGTGTGTGGGGATGCCGGGCTGAAATTCAACAGCCTTGCAAAAAGAAAGGGAAGATGGGATGTGTTAATATTGTAGTG GCATGCACTTTCCAGCTCTCCATGGAGCTCTCTTTATATATGAGGTAATTGAATGTCACTATTCTGTACCATACAGCAGGTATTATCTAGCCAAGGTTAT AATTACCATGAAGTGCTGTGGAATGTAGTAGGAGGCTTTTCACTGGG

BID.u.f.10 (forward primer)
BID.u.r.14 (reverse primer)
Single exon skipping

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP PRLEGDSESQEDIIRNIARHLAQVGDSMDRSIPP GLVNGLALQLRNTSRSEEDRNRDLATALEQLLQ AYPRDMEKEKTMLVLALLLAKKVASHTPSLLRD VFHTTVNFINQNLRTYVRSLARNGMD*TDSSRSV TG*SSMWSQLYSCFQCRRSPGMSTAFLEKTGWK IAVTSILKTMLNL*PTLKYLH*YT*MKMSIYTY LNGLHIIHT*ICTSVNLHTVPLFPLCRFPLKN*I GKQVSRK*KQNTIFLVKKNYCLLKYNHRGWSYS RQYPV*GKQESEKEHTPYK*KIPLKIGTIYLNT KEPTIFLFKKPHGTEILN*SAALK*WEVRPQYTG A*LFQLRFLCWSQKEPLVVLKGVKVI*GPRSAT VCLQNQVTNCIHFFSFHDIKTLLKT*SHGCQKL LRCPGS*PPGNSCKLPISSHTLSSSMPQKCIWRE QVSKHKR*KSSWTF*KFSKVVPSLRDSQNQVT* VVPK*IRKSLALETVQHWSAVPVVSYVPGISLK ARQWMLGPYHTHCCEQETPVTTT*GHWRRI*VRA LTDS*FLLTRCFPVL*EFKIIRKEKQTLYCSAC NTYHARAGSIESGQKLTNTKKKCCRAVWRPLFG NKSS*HYDFSCFGVDF*KSFPTTMETG*TTLRLH IHPYVSHYNQILTGGGIFFPKELYAVITRN*WE SVLKQQVTLDHLSHTLTLPQHLHLLLFHLNSYS RPPFYNRS*CKFFQTKSEIVLVVKQDRHPFSQSQ HYKKIPLSQTQMFQS*ALPSHGDSGISWQLVDF AL*HNPCGYDSKVTLIQRMCFPFCFKNI*IK*W KFFC*TSKAFSLKRCLVYLKVTWDIWCIQKVKSF LTSPLRTQH*LLRYSRLP*RITALAPSFTVQQL Y*LC*LRIGI*SPLNVTILFSKPGVKPIKYGLN KDN**CEMIPPVKGIVTMWIER*VH*LSSNPMYS L*HVASDRKNNSQI*SLFLSPDEE*IGQKVDDR KEEEPE*PTVISSAVQSGSAEAHGTHTEKGNTC CLKCTIT*LSKLPFNSGIFEMKAFEPTLN*P*LR NEVGRGTFNLEEEINGRL**EKYRSRKKIIFFL *CWPRTPLHNTVLLLESIRANRVIPNSATGKTV L*PSFPGEREQLVIFKCQNFSSK*YIH*PVSSGG AKNTHHSEQYHYSISPLER*QRGRITWSQLLVF N**QGLANTPENNFTLSSQGSSSLVWAPVV*PS NVEDLMVLVCGDAGLKFNSLAKRKGRWDVLIL*W HALSSSPWSSLYI*GN*MSLFCTIQQVLSSQGY NYHEVLWNVVGGFSL

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP RGWRVILKVKKTSSGILPGTSPRSGTAWTVASL RAW*TAWPCSSGTPAGRRRTGTGTWPLPWSSCCR PTLETWRRRRPCWCWPCCWPRRWPVTRRPCSVM SFTQQ*ILLTRTYAPT*GA*PEMGWTERTVPEV *LAKARCGHSCIAASSVDGALACQQRS*RRQAGR *L*LLF*RQC*TYNPL*NIYINILE*KCPFTRI *MAFISSTHESAHL*IYTRCLYFHCAGSHLKIK LESRFQGSRNKIQFFW*KKITVY*STTIEDGLTA GSILFEESKNQRRNIPLTNEKFHSK*GLSILIL RNQQSSCLKNHMAQRF*TKVLHSNDGKSGPSTQ GLDFFNFVSFVGVKKNHLWF*KV*R*FKGPGQPL FVYKIR*LTAYTFSLSMTSRLC*RHEATGARSY CDAPGVSPLVIAVNFQFLAIRSAHPCLRSASGE NRFLSIKDERAVGLFKNSAKWFPLLGTVKTKSLR *YQNK*GKA*L*KQCNTGLLFQW*AMSQESV*K HDSGCWVHITHIAVNRKLL*PQHEATGDAYE*G H*RTHDFFLPDAFLFFKSLKSSERKNKLYIVQHA IHTTLGLAQLKVGKSLQILKRSAAAQCGGHCLE INLPNTTTFHVLEWTFKKVFQPQWKQVEPHCAY TSIHTSAIIIRFSLGEAFSSQRSCMQSSPGTNGK VFLSSK*LWTTSLTH*LFHSIFTCFCFT*IHTV GHHFITGLSVNSSRPSLR*SWL*SKTVTPSPKA NIIKRFHCLKHKCSSLEHFPAMVTRAYPGSWWIL PCNTILVDMIQR*L*FRECVFLSVLKIFELSDG NSFVKHQKLSP*KDAWCI*KSRGTFGAFRRSNH S*PLLLGPSINCCDTQGFLKGSQHWRLVLLSSNF ISCAS*ELEYRVL*MLRSCFQNLESNQLSMDLT KTIDDVK*YHLSRA*LPCG*KDESTDYLQIPCI LSSTLLLTERITHRFEVCSFPLMKSRLAKR*MTG RKRSQNDPQ*SVQQCRAAVQRLMELTRKKETHA A*NAR*LNYPNYHSIPVFLR*KHLSQH*IDLN* GMR*EEALLIWRKK*MEDCNRKNTGLGKK*FFSF DAGQGPLYIIQFSCWKASGQTELFQTLQQGRLY FDLLFLGKGNN**SLNVKTFLLNSTFINQFLLV VQRTLTTVSNTTIQFPLWRGDSGVESPGVSC*SL TDDKALQIPLRTISL*AHREAAVWCGLLWCNHQ MWKT*WC*CVGMPG*NSTALQKEREDGMC*YCS GMHFPALHGALFIYEVIECHYSVPYSRYYLAKVI ITMKCCGM**EAFHW

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP AAGG*F*KSRRHHPEYCQAPRPGRGQHGP*HPS GPGERPGPAAQEHQPVGGGPEQGPGHCPGAAAA GLP*RHGEGEDHAGAGPAAGQEGGQSHAVLAP*C LSHNSEFY*PEPTHLREELSQKWDGLNGQFQKC DWLKLDVVTAV*LLPV*TEPWHVNSVPREDRLE DSCDFYFKDNVKLITHFKISTLIYLNENVHLHVF EWPSYHPHMNLHICKSTHGAFISTVQVPT*KLN WKAGFKEVETKYNFFGKKKLLFIKVQP*RMVLQ QAVSCLRKARIREGTYPLQMKNSTQNRDYLS*Y* GTNNLPV*KTTWHRDSELKCCTQMMGSPAPVHR GLTFSTSFPLLESKRTTCGSKRCEGDLRAQVSH CLFTKSGN*LHTLFLFP*HQDFAKDMKPRVPEAT AMPRELAPW**L*TSNF*PYAQLIHASEVHLER TGF*A*KMKEQLDFLKIQQSGSLS*GQSKPSHL GSTKINKEKLSFRNSATLVCCSSGKLCPRNQFKS TTVDAGSISHTLL*TGNSCDHNMRPLETHMSKG TDGLMISSYQMLSCSLRV*NHQKGKTNSILFSM QYIPR*GWLN*KWAKAYKY*KEVLPRSVEATVWK *IFLTLRLFMFWSGLLKKFSNHNGNRLNHTAPT HPSIRQPL*SDSHWGRHFLPKGAVCSHHPELMG KCS*AASDSGPPLSHTDSSTASSPASVSLEFIQ* ATIL*QVLV*ILPDQV*DSLGCKARPSPLLPKP TL*KDSIVSNTNVPVLSTSQPW*LGHILAVGGF CPVTQSLWI*FKGDFNSENVFSFLF*KYLN*VME ILLLNIKSFLLEKMLGVSESHVGHLVHSEGQII PDLSS*DPALTAAILKASLKDHSTGA*FYCPAT LLVVLAENWNIESFECYDLVFKTWSQTN*VWT*Q RQLMM*NDTTCQGHSYHVDRKMSPLIIFKSHVF SLARCF*QKE*LTDLKFVPFP**RVDWPKGR*Q EGRGARMTHSDQFSSAERQCRGSWNSHGKRKHML LKMHDNLIIQITIQFRYF*DESI*ANTKLTLIK E*GRKRHF*SGGRNKWKTVIGKIQV*EKNNFFP LMLAKDPST*YSSPAGKHQGKQSYSKLCNREDCT LTFFSWGKGTTSNL*MSKLFF*IVHSLTSFFWW CKEHSPQ*AIPLFNFPFGEVTAG*NHLESAASL *LMTRPCKYP*EQFHSELTGKQQSGVGSCGVTIK CGRPDGVSVWGCRAEIQQPCKKKGKMGCVNIVV ACTFQLSMELSLYMR*LNVTILYHTAGII*PRL *LP*SAVECSRRLFTG

Sequence BID.jAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC CGCGGCTGGAGGGTGGTCGCCACTGGGACACTGTGAACCAGGAGTGAGTCGGAGCTGCCGCGCTGCCCAGGCCATGGACTGTGAGATTCTGAAAGTCAAG AAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTGAACGGCCTGGCCCTGCAGCT CAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGGAGAAGGAGAAG ACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACAACAGTGAATTTTATTAACC AGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGATGTGGTCACAGCT GTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTGTGACTTCTATTTTAAAGACAATG TTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACA ACATGAGGCCACTGGAGACGCATATGAGTAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCA GAAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAA GTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAAATAAATCTTCCTAACACTACGACTTTTCATGTTTTGGAGTGGACTTTTAAAAAAGTTTTCCAACC ACAATGGAAACAGGTTGAACCACACTGCGCCTACACATCCATCCATACGTCAGCCATTATAATCAGATTCTCACTGGGGGAGGCATTTTCTTCCCAAAGG AGCTGTATGCAGTCATCACCCGGAACTAATGGGAAAGTGTTCTTAAGCAGCAAGTGACTCTGGACCACCTCTCTCACACACTGACTCTTCCACAGCATCT TCACCTGCTTCTGTTTCACTTGAATTCATACAGTAGGCCACCATTTTATAACAGGTCTTAGTGTAAATTCTTCCAGACCAAGTCTGAGATAGTCTTGGTT GTAAAGCAAGACCGTCACCCCTTCTCCCAAAGCCAACATTATAAAAAGATTCCATTGTCTCAAACACAAATGTTCCAGTCTTGAGCACTTCCCAGCCATG GTGACTCGGGCATATCCTGGCAGTTGGTGGATTTTGCCCTGTAACACAATCCTTGTGGATATGATTCAAAGGTGACTTTAATTCAGAGAATGTGTTTTCC TTTCTGTTTTAAAAATATTTGAATTAAGTGATGGAAATTCTTTTGTTAAACATCAAAAGCTTTCTCCTTGAAAAGATGCTTGGTGTATCTGAAAGTCACG TGGGACATTTGGTGCATTCAGAAGGTCAAATCATTCCTGACCTCTCCTCTTAGGACCCAGCATTAACTGCTGCGATACTCAAGGCTTCCTTAAAGGATCA CAGCACTGGCGCCTAGTTTTACTGTCCAGCAACTTTATTAGTTGTGCTAGCTGAGAATTGGAATATAGAGTCCTTTGAATGTTACGATCTTGTTTTCAAA ACCTGGAGTCAAACCAATTAAGTATGGACTTAACAAAGACAATTGATGATGTGAAATGATACCACCTGTCAAGGGCATAGTTACCATGTGGATAGAAAGA TGAGTCCACTGATTATCTTCAAATCCCATGTATTCTCTCTAGCACGTTGCTTCTGACAGAAAGAATAACTCACAGATTTGAAGTTTGTTCCTTTCCCCTG ATGAAGAGTAGATTGGCCAAAAGGTAGATGACAGGAAGGAAGAGGAGCCAGAATGACCCACAGTGATCAGTTCAGCAGTGCAGAGCGGCAGTGCAGAGGC TCATGGAACTCACACGGAAAAAGGAAACACATGCTGCTTAAAATGCACGATAACTTAATTATCCAAATTACCATTCAATTCCGGTATTTTTGAGATGAAA GCATTTGAGCCAACACTAAATTGACCTTAATTAAGGAATGAGGTAGGAAGAGGCACTTTTAATCTGGAGGAAGAAATAAATGGAAGACTGTAATAGGAAA AATACAGGTCTAGGAAAAAAATAATTTTTTTCCTTTGATGCTGGCCAAGGACCCCTCTACATAATACAGTTCTCCTGCTGGAAAGCATCAGGGCAAACAG AGTTATTCCAAACTCTGCAACAGGGAAGACTGTACTTTGACCTTCTTTTCCTGGGGAAAGGGAACAACTAGTAATCTTTAAATGTCAAAACTTTTCTTCT AAATAGTACATTCATTAACCAGTTTCTTCTGGTGGTGCAAAGAACACTCACCACAGTGAGCAATACCACTATTCAATTTCCCCTTTGGAGAGGTGACAGC GGGGTAGAATCACCTGGAGTCAGCTGCTAGTCTTTAACTGATGACAAGGCCTTGCAAATACCCCTGAGAACAATTTCACTCTGAGCTCACAGGGAAGCAG CAGTCTGGTGTGGGCTCCTGTGGTGTAACCATCAAATGTGGAAGACCTGATGGTGTTAGTGTGTGGGGATGCCGGGCTGAAATTCAACAGCCTTGCAAAA AGAAAGGGAAGATGGGATGTGTTAATATTGTAGTGGCATGCACTTTCCAGCTCTCCATGGAGCTCTCTTTATATATGAGGTAATTGAATGTCACTATTCT GTACCATACAGCAGGTATTATCTAGCCAAGGTTATAATTACCATGAAGTGCTGTGGAATGTAGTAGGAGGCTTTTCACTGGG

BID.u.f.10 (forward primer)
BID.u.r.14 (reverse primer)
Single exon skipping

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP PRLEGGRHWDTVNQE*VGAAALPRPWTVRF*KSR RHHPEYCQAPRPGRGQHGP*HPSGPGERPGPAA QEHQPVGGGPEQGPGHCPGAAAAGLP*RHGEGE DHAGAGPAAGQEGGQSHAVLAP*CLSHNSEFY*P EPTHLREELSQKWDGLNGQFQKCDWLKLDVVTA V*LLPV*TEPWHVNSVPREDRLEDSCDFYFKDN VKLITHFKISTLIYLNENVHITHIAVNRKLL*PQ HEATGDAYE*GH*RTHDFFLPDAFLFFKSLKSS ERKNKLYIVQHAIHTTLGLAQLKVGKSLQILKR SAAAQCGGHCLEINLPNTTTFHVLEWTFKKVFQP QWKQVEPHCAYTSIHTSAIIIRFSLGEAFSSQR SCMQSSPGTNGKVFLSSK*LWTTSLTH*LFHSI FTCFCFT*IHTVGHHFITGLSVNSSRPSLR*SWL *SKTVTPSPKANIIKRFHCLKHKCSSLEHFPAM VTRAYPGSWWILPCNTILVDMIQR*L*FRECVF LSVLKIFELSDGNSFVKHQKLSP*KDAWCI*KSR GTFGAFRRSNHS*PLLLGPSINCCDTQGFLKGS QHWRLVLLSSNFISCAS*ELEYRVL*MLRSCFQ NLESNQLSMDLTKTIDDVK*YHLSRA*LPCG*KD ESTDYLQIPCILSSTLLLTERITHRFEVCSFPL MKSRLAKR*MTGRKRSQNDPQ*SVQQCRAAVQR LMELTRKKETHAA*NAR*LNYPNYHSIPVFLR*K HLSQH*IDLN*GMR*EEALLIWRKK*MEDCNRK NTGLGKK*FFSFDAGQGPLYIIQFSCWKASGQT ELFQTLQQGRLYFDLLFLGKGNN**SLNVKTFLL NSTFINQFLLVVQRTLTTVSNTTIQFPLWRGDS GVESPGVSC*SLTDDKALQIPLRTISL*AHREA AVWCGLLWCNHQMWKT*WC*CVGMPG*NSTALQK EREDGMC*YCSGMHFPALHGALFIYEVIECHYS VPYSRYYLAKVIITMKCCGM**EAFHW

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP RGWRVVATGTL*TRSESELPRCPGHGL*DSESQ EDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQL RNTSRSEEDRNRDLATALEQLLQAYPRDMEKEK TMLVLALLLAKKVASHTPSLLRDVFHTTVNFIN QNLRTYVRSLARNGMD*TDSSRSVTG*SSMWSQL YSCFQCRRSPGMSTAFLEKTGWKIAVTSILKTM LNL*PTLKYLH*YT*MKMSISHTLL*TGNSCDH NMRPLETHMSKGTDGLMISSYQMLSCSLRV*NHQ KGKTNSILFSMQYIPR*GWLN*KWAKAYKY*KE VLPRSVEATVWK*IFLTLRLFMFWSGLLKKFSN HNGNRLNHTAPTHPSIRQPL*SDSHWGRHFLPKG AVCSHHPELMGKCS*AASDSGPPLSHTDSSTAS SPASVSLEFIQ*ATIL*QVLV*ILPDQV*DSLG CKARPSPLLPKPTL*KDSIVSNTNVPVLSTSQPW *LGHILAVGGFCPVTQSLWI*FKGDFNSENVFS FLF*KYLN*VMEILLLNIKSFLLEKMLGVSESH VGHLVHSEGQIIPDLSS*DPALTAAILKASLKDH STGA*FYCPATLLVVLAENWNIESFECYDLVFK TWSQTN*VWT*QRQLMM*NDTTCQGHSYHVDRK MSPLIIFKSHVFSLARCF*QKE*LTDLKFVPFP* *RVDWPKGR*QEGRGARMTHSDQFSSAERQCRG SWNSHGKRKHMLLKMHDNLIIQITIQFRYF*DE SI*ANTKLTLIKE*GRKRHF*SGGRNKWKTVIGK IQV*EKNNFFPLMLAKDPST*YSSPAGKHQGKQ SYSKLCNREDCTLTFFSWGKGTTSNL*MSKLFF *IVHSLTSFFWWCKEHSPQ*AIPLFNFPFGEVTA G*NHLESAASL*LMTRPCKYP*EQFHSELTGKQ QSGVGSCGVTIKCGRPDGVSVWGCRAEIQQPCK KKGKMGCVNIVVACTFQLSMELSLYMR*LNVTIL YHTAGII*PRL*LP*SAVECSRRLFTG

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP AAGGWSPLGHCEPGVSRSCRAAQAMDCEILKVK KTSSGILPGTSPRSGTAWTVASLRAW*TAWPCS SGTPAGRRRTGTGTWPLPWSSCCRPTLETWRRRR PCWCWPCCWPRRWPVTRRPCSVMSFTQQ*ILLT RTYAPT*GA*PEMGWTERTVPEV*LAKARCGHS CIAASSVDGALACQQRS*RRQAGR*L*LLF*RQC *TYNPL*NIYINILE*KCPYHTHCCEQETPVTT T*GHWRRI*VRALTDS*FLLTRCFPVL*EFKII RKEKQTLYCSACNTYHARAGSIESGQKLTNTKKK CCRAVWRPLFGNKSS*HYDFSCFGVDF*KSFPT TMETG*TTLRLHIHPYVSHYNQILTGGGIFFPK ELYAVITRN*WESVLKQQVTLDHLSHTLTLPQHL HLLLFHLNSYSRPPFYNRS*CKFFQTKSEIVLV VKQDRHPFSQSQHYKKIPLSQTQMFQS*ALPSH GDSGISWQLVDFAL*HNPCGYDSKVTLIQRMCFP FCFKNI*IK*WKFFC*TSKAFSLKRCLVYLKVT WDIWCIQKVKSFLTSPLRTQH*LLRYSRLP*RI TALAPSFTVQQLY*LC*LRIGI*SPLNVTILFSK PGVKPIKYGLNKDN**CEMIPPVKGIVTMWIER *VH*LSSNPMYSL*HVASDRKNNSQI*SLFLSP DEE*IGQKVDDRKEEEPE*PTVISSAVQSGSAEA HGTHTEKGNTCCLKCTIT*LSKLPFNSGIFEMK AFEPTLN*P*LRNEVGRGTFNLEEEINGRL**E KYRSRKKIIFFL*CWPRTPLHNTVLLLESIRANR VIPNSATGKTVL*PSFPGEREQLVIFKCQNFSS K*YIH*PVSSGGAKNTHHSEQYHYSISPLER*Q RGRITWSQLLVFN**QGLANTPENNFTLSSQGSS SLVWAPVV*PSNVEDLMVLVCGDAGLKFNSLAK RKGRWDVLIL*WHALSSSPWSSLYI*GN*MSLF CTIQQVLSSQGYNYHEVLWNVVGGFSL