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Sequences

Sequence BID.jAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC
CGCGGCTGGAGGGTGGTCGCCACTGGGACACTGTGAACCAGGAGTGAGTCGGAGCTGCCGCGCTGCCCAGGCCATGGACTGTGAGATTCTGAAAGTCAAG
AAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTGAACGGCCTGGCCCTGCAGCT
CAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGGAGAAGGAGAAG
ACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACAACAGTGAATTTTATTAACC
AGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGATGTGGTCACAGCT
GTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTGTGACTTCTATTTTAAAGACAATG
TTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACA
ACATGAGGCCACTGGAGACGCATATGAGTAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCA
GAAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAA
GTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAAATAAATCTTCCTAACACTACGACTTTTCATGTTTTGGAGTGGACTTTTAAAAAAGTTTTCCAACC
ACAATGGAAACAGGTTGAACCACACTGCGCCTACACATCCATCCATACGTCAGCCATTATAATCAGATTCTCACTGGGGGAGGCATTTTCTTCCCAAAGG
AGCTGTATGCAGTCATCACCCGGAACTAATGGGAAAGTGTTCTTAAGCAGCAAGTGACTCTGGACCACCTCTCTCACACACTGACTCTTCCACAGCATCT
TCACCTGCTTCTGTTTCACTTGAATTCATACAGTAGGCCACCATTTTATAACAGGTCTTAGTGTAAATTCTTCCAGACCAAGTCTGAGATAGTCTTGGTT
GTAAAGCAAGACCGTCACCCCTTCTCCCAAAGCCAACATTATAAAAAGATTCCATTGTCTCAAACACAAATGTTCCAGTCTTGAGCACTTCCCAGCCATG
GTGACTCGGGCATATCCTGGCAGTTGGTGGATTTTGCCCTGTAACACAATCCTTGTGGATATGATTCAAAGGTGACTTTAATTCAGAGAATGTGTTTTCC
TTTCTGTTTTAAAAATATTTGAATTAAGTGATGGAAATTCTTTTGTTAAACATCAAAAGCTTTCTCCTTGAAAAGATGCTTGGTGTATCTGAAAGTCACG
TGGGACATTTGGTGCATTCAGAAGGTCAAATCATTCCTGACCTCTCCTCTTAGGACCCAGCATTAACTGCTGCGATACTCAAGGCTTCCTTAAAGGATCA
CAGCACTGGCGCCTAGTTTTACTGTCCAGCAACTTTATTAGTTGTGCTAGCTGAGAATTGGAATATAGAGTCCTTTGAATGTTACGATCTTGTTTTCAAA
ACCTGGAGTCAAACCAATTAAGTATGGACTTAACAAAGACAATTGATGATGTGAAATGATACCACCTGTCAAGGGCATAGTTACCATGTGGATAGAAAGA
TGAGTCCACTGATTATCTTCAAATCCCATGTATTCTCTCTAGCACGTTGCTTCTGACAGAAAGAATAACTCACAGATTTGAAGTTTGTTCCTTTCCCCTG
ATGAAGAGTAGATTGGCCAAAAGGTAGATGACAGGAAGGAAGAGGAGCCAGAATGACCCACAGTGATCAGTTCAGCAGTGCAGAGCGGCAGTGCAGAGGC
TCATGGAACTCACACGGAAAAAGGAAACACATGCTGCTTAAAATGCACGATAACTTAATTATCCAAATTACCATTCAATTCCGGTATTTTTGAGATGAAA
GCATTTGAGCCAACACTAAATTGACCTTAATTAAGGAATGAGGTAGGAAGAGGCACTTTTAATCTGGAGGAAGAAATAAATGGAAGACTGTAATAGGAAA
AATACAGGTCTAGGAAAAAAATAATTTTTTTCCTTTGATGCTGGCCAAGGACCCCTCTACATAATACAGTTCTCCTGCTGGAAAGCATCAGGGCAAACAG
AGTTATTCCAAACTCTGCAACAGGGAAGACTGTACTTTGACCTTCTTTTCCTGGGGAAAGGGAACAACTAGTAATCTTTAAATGTCAAAACTTTTCTTCT
AAATAGTACATTCATTAACCAGTTTCTTCTGGTGGTGCAAAGAACACTCACCACAGTGAGCAATACCACTATTCAATTTCCCCTTTGGAGAGGTGACAGC
GGGGTAGAATCACCTGGAGTCAGCTGCTAGTCTTTAACTGATGACAAGGCCTTGCAAATACCCCTGAGAACAATTTCACTCTGAGCTCACAGGGAAGCAG
CAGTCTGGTGTGGGCTCCTGTGGTGTAACCATCAAATGTGGAAGACCTGATGGTGTTAGTGTGTGGGGATGCCGGGCTGAAATTCAACAGCCTTGCAAAA
AGAAAGGGAAGATGGGATGTGTTAATATTGTAGTGGCATGCACTTTCCAGCTCTCCATGGAGCTCTCTTTATATATGAGGTAATTGAATGTCACTATTCT
GTACCATACAGCAGGTATTATCTAGCCAAGGTTATAATTACCATGAAGTGCTGTGGAATGTAGTAGGAGGCTTTTCACTGGG
  • BID.u.f.10 (forward primer)
  • BID.u.r.14 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP
PRLEGGRHWDTVNQE*VGAAALPRPWTVRF*KSR
RHHPEYCQAPRPGRGQHGP*HPSGPGERPGPAA
QEHQPVGGGPEQGPGHCPGAAAAGLP*RHGEGE
DHAGAGPAAGQEGGQSHAVLAP*CLSHNSEFY*P
EPTHLREELSQKWDGLNGQFQKCDWLKLDVVTA
V*LLPV*TEPWHVNSVPREDRLEDSCDFYFKDN
VKLITHFKISTLIYLNENVHITHIAVNRKLL*PQ
HEATGDAYE*GH*RTHDFFLPDAFLFFKSLKSS
ERKNKLYIVQHAIHTTLGLAQLKVGKSLQILKR
SAAAQCGGHCLEINLPNTTTFHVLEWTFKKVFQP
QWKQVEPHCAYTSIHTSAIIIRFSLGEAFSSQR
SCMQSSPGTNGKVFLSSK*LWTTSLTH*LFHSI
FTCFCFT*IHTVGHHFITGLSVNSSRPSLR*SWL
*SKTVTPSPKANIIKRFHCLKHKCSSLEHFPAM
VTRAYPGSWWILPCNTILVDMIQR*L*FRECVF
LSVLKIFELSDGNSFVKHQKLSP*KDAWCI*KSR
GTFGAFRRSNHS*PLLLGPSINCCDTQGFLKGS
QHWRLVLLSSNFISCAS*ELEYRVL*MLRSCFQ
NLESNQLSMDLTKTIDDVK*YHLSRA*LPCG*KD
ESTDYLQIPCILSSTLLLTERITHRFEVCSFPL
MKSRLAKR*MTGRKRSQNDPQ*SVQQCRAAVQR
LMELTRKKETHAA*NAR*LNYPNYHSIPVFLR*K
HLSQH*IDLN*GMR*EEALLIWRKK*MEDCNRK
NTGLGKK*FFSFDAGQGPLYIIQFSCWKASGQT
ELFQTLQQGRLYFDLLFLGKGNN**SLNVKTFLL
NSTFINQFLLVVQRTLTTVSNTTIQFPLWRGDS
GVESPGVSC*SLTDDKALQIPLRTISL*AHREA
AVWCGLLWCNHQMWKT*WC*CVGMPG*NSTALQK
EREDGMC*YCSGMHFPALHGALFIYEVIECHYS
VPYSRYYLAKVIITMKCCGM**EAFHW

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP
RGWRVVATGTL*TRSESELPRCPGHGL*DSESQ
EDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQL
RNTSRSEEDRNRDLATALEQLLQAYPRDMEKEK
TMLVLALLLAKKVASHTPSLLRDVFHTTVNFIN
QNLRTYVRSLARNGMD*TDSSRSVTG*SSMWSQL
YSCFQCRRSPGMSTAFLEKTGWKIAVTSILKTM
LNL*PTLKYLH*YT*MKMSISHTLL*TGNSCDH
NMRPLETHMSKGTDGLMISSYQMLSCSLRV*NHQ
KGKTNSILFSMQYIPR*GWLN*KWAKAYKY*KE
VLPRSVEATVWK*IFLTLRLFMFWSGLLKKFSN
HNGNRLNHTAPTHPSIRQPL*SDSHWGRHFLPKG
AVCSHHPELMGKCS*AASDSGPPLSHTDSSTAS
SPASVSLEFIQ*ATIL*QVLV*ILPDQV*DSLG
CKARPSPLLPKPTL*KDSIVSNTNVPVLSTSQPW
*LGHILAVGGFCPVTQSLWI*FKGDFNSENVFS
FLF*KYLN*VMEILLLNIKSFLLEKMLGVSESH
VGHLVHSEGQIIPDLSS*DPALTAAILKASLKDH
STGA*FYCPATLLVVLAENWNIESFECYDLVFK
TWSQTN*VWT*QRQLMM*NDTTCQGHSYHVDRK
MSPLIIFKSHVFSLARCF*QKE*LTDLKFVPFP*
*RVDWPKGR*QEGRGARMTHSDQFSSAERQCRG
SWNSHGKRKHMLLKMHDNLIIQITIQFRYF*DE
SI*ANTKLTLIKE*GRKRHF*SGGRNKWKTVIGK
IQV*EKNNFFPLMLAKDPST*YSSPAGKHQGKQ
SYSKLCNREDCTLTFFSWGKGTTSNL*MSKLFF
*IVHSLTSFFWWCKEHSPQ*AIPLFNFPFGEVTA
G*NHLESAASL*LMTRPCKYP*EQFHSELTGKQ
QSGVGSCGVTIKCGRPDGVSVWGCRAEIQQPCK
KKGKMGCVNIVVACTFQLSMELSLYMR*LNVTIL
YHTAGII*PRL*LP*SAVECSRRLFTG

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP
AAGGWSPLGHCEPGVSRSCRAAQAMDCEILKVK
KTSSGILPGTSPRSGTAWTVASLRAW*TAWPCS
SGTPAGRRRTGTGTWPLPWSSCCRPTLETWRRRR
PCWCWPCCWPRRWPVTRRPCSVMSFTQQ*ILLT
RTYAPT*GA*PEMGWTERTVPEV*LAKARCGHS
CIAASSVDGALACQQRS*RRQAGR*L*LLF*RQC
*TYNPL*NIYINILE*KCPYHTHCCEQETPVTT
T*GHWRRI*VRALTDS*FLLTRCFPVL*EFKII
RKEKQTLYCSACNTYHARAGSIESGQKLTNTKKK
CCRAVWRPLFGNKSS*HYDFSCFGVDF*KSFPT
TMETG*TTLRLHIHPYVSHYNQILTGGGIFFPK
ELYAVITRN*WESVLKQQVTLDHLSHTLTLPQHL
HLLLFHLNSYSRPPFYNRS*CKFFQTKSEIVLV
VKQDRHPFSQSQHYKKIPLSQTQMFQS*ALPSH
GDSGISWQLVDFAL*HNPCGYDSKVTLIQRMCFP
FCFKNI*IK*WKFFC*TSKAFSLKRCLVYLKVT
WDIWCIQKVKSFLTSPLRTQH*LLRYSRLP*RI
TALAPSFTVQQLY*LC*LRIGI*SPLNVTILFSK
PGVKPIKYGLNKDN**CEMIPPVKGIVTMWIER
*VH*LSSNPMYSL*HVASDRKNNSQI*SLFLSP
DEE*IGQKVDDRKEEEPE*PTVISSAVQSGSAEA
HGTHTEKGNTCCLKCTIT*LSKLPFNSGIFEMK
AFEPTLN*P*LRNEVGRGTFNLEEEINGRL**E
KYRSRKKIIFFL*CWPRTPLHNTVLLLESIRANR
VIPNSATGKTVL*PSFPGEREQLVIFKCQNFSS
K*YIH*PVSSGGAKNTHHSEQYHYSISPLER*Q
RGRITWSQLLVFN**QGLANTPENNFTLSSQGSS
SLVWAPVV*PSNVEDLMVLVCGDAGLKFNSLAK
RKGRWDVLIL*WHALSSSPWSSLYI*GN*MSLF
CTIQQVLSSQGYNYHEVLWNVVGGFSL

Sequence BID.iAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC
CGCGGCTGGAGGGTGGTCAACAACGGTTCCAGCCTCAGGGATGAGTGCATCACAAACCTACTGGTGTTTGGCTTCCTCCAAAGCTGTTCTGACAACAGCT
TCCGCAGAGAGCTGGACGCACTGGGCCACGAGCTGCCAGTGCTGGCTCCCCAGTGGGAGGGCTACGATGAGCTGCAGACTGATGGCAACCGCAGCAGCCA
CTCCCGCTTGGGAAGAATAGAG
ATTCTGAAAGTCAAGAAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCA
TCCCTCCGGGCCTGGTGAACGGCCTGGCCCTGCAGCTCAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCT
GCTGCAGGCCTACCCTAGAGACATGGAGAAGGAGAAGACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTC
CGTGATGTCTTTCACACAACAGTGAATTTTATTAACCAGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCA
GAAGTGTGACTGGCTAAAGCTCGATGTGGTCACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGG
CTGGAAGATAGCTGTGACTTCTATTTTAAAGACAATGTTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATTTAC
ACGTATTTGAATGGCCTTCATATCATCCACACATGAATCTGCACATCTGTAAATCTACACACGGTGCCTTTATTTCCACTGTGCAGGTTCCCACTTAAAA
ATTAAATTGGAAAGCAGGTTTCAAGGAAGTAGAAACAAAATACAATTTTTTTGGTAAAAAAAAATTACTGTTTATTAAAGTACAACCATAGAGGATGGTC
TTACAGCAGGCAGTATCCTGTTTGAGGAAAGCAAGAATCAGAGAAGGAACATACCCCTTACAAATGAAAAATTCCACTCAAAATAGGGACTATCTATCTT
AATACTAAGGAACCAACAATCTTCCTGTTTAAAAAACCACATGGCACAGAGATTCTGAACTAAAGTGCTGCACTCAAATGATGGGAAGTCCGGCCCCAGT
ACACAGGGGCTTGACTTTTTCAACTTCGTTTCCTTTGTTGGAGTCAAAAAGAACCACTTGTGGTTCTAAAAGGTGTGAAGGTGATTTAAGGGCCCAGGTC
AGCCACTGTTTGTTTACAAAATCAGGTAACTAACTGCATACACTTTTTCTCTTTCCATGACATCAAGACTTTGCTAAAGACATGAAGCCACGGGTGCCAG
AAGCTACTGCGATGCCCCGGGAGTTAGCCCCCTGGTAATAGCTGTAAACTTCCAATTTCTAGCCATACGCTCAGCTCATCCATGCCTCAGAAGTGCATCT
GGAGAGAACAGGTTTCTAAGCATAAAAGATGAAAGAGCAGTTGGACTTTTTAAAAATTCAGCAAAGTGGTTCCCTCTCTTAGGGACAGTCAAAACCAAGT
CACTTAGGTAGTACCAAAATAAATAAGGAAAAGCTTAGCTTTAGAAACAGTGCAACACTGGTCTGCTGTTCCAGTGGTAAGCTATGTCCCAGGAATCAGT
TTAAAAGCACGACAGTGGATGCTGGGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACAACATGAGGCCACTGGAGACGCATATGAG
TAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCAGAAAGGAAAAACAAACTCTATATTGTTC
AGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAAGTGCTGCCGCGCAGTGTGGAGGCCACTG
TTTGGAAATAAATCTTCCTAACACTACGACTTTTCATGTTTTGGAGTGGACTTTTAAAAAAGTTTTCCAACCACAATGGAAACAGGTTGAACCACACTGC
GCCTACACATCCATCCATACGTCAGCCATTATAATCAGATTCTCACTGGGGGAGGCATTTTCTTCCCAAAGGAGCTGTATGCAGTCATCACCCGGAACTA
ATGGGAAAGTGTTCTTAAGCAGCAAGTGACTCTGGACCACCTCTCTCACACACTGACTCTTCCACAGCATCTTCACCTGCTTCTGTTTCACTTGAATTCA
TACAGTAGGCCACCATTTTATAACAGGTCTTAGTGTAAATTCTTCCAGACCAAGTCTGAGATAGTCTTGGTTGTAAAGCAAGACCGTCACCCCTTCTCCC
AAAGCCAACATTATAAAAAGATTCCATTGTCTCAAACACAAATGTTCCAGTCTTGAGCACTTCCCAGCCATGGTGACTCGGGCATATCCTGGCAGTTGGT
GGATTTTGCCCTGTAACACAATCCTTGTGGATATGATTCAAAGGTGACTTTAATTCAGAGAATGTGTTTTCCTTTCTGTTTTAAAAATATTTGAATTAAG
TGATGGAAATTCTTTTGTTAAACATCAAAAGCTTTCTCCTTGAAAAGATGCTTGGTGTATCTGAAAGTCACGTGGGACATTTGGTGCATTCAGAAGGTCA
AATCATTCCTGACCTCTCCTCTTAGGACCCAGCATTAACTGCTGCGATACTCAAGGCTTCCTTAAAGGATCACAGCACTGGCGCCTAGTTTTACTGTCCA
GCAACTTTATTAGTTGTGCTAGCTGAGAATTGGAATATAGAGTCCTTTGAATGTTACGATCTTGTTTTCAAAACCTGGAGTCAAACCAATTAAGTATGGA
CTTAACAAAGACAATTGATGATGTGAAATGATACCACCTGTCAAGGGCATAGTTACCATGTGGATAGAAAGATGAGTCCACTGATTATCTTCAAATCCCA
TGTATTCTCTCTAGCACGTTGCTTCTGACAGAAAGAATAACTCACAGATTTGAAGTTTGTTCCTTTCCCCTGATGAAGAGTAGATTGGCCAAAAGGTAGA
TGACAGGAAGGAAGAGGAGCCAGAATGACCCACAGTGATCAGTTCAGCAGTGCAGAGCGGCAGTGCAGAGGCTCATGGAACTCACACGGAAAAAGGAAAC
ACATGCTGCTTAAAATGCACGATAACTTAATTATCCAAATTACCATTCAATTCCGGTATTTTTGAGATGAAAGCATTTGAGCCAACACTAAATTGACCTT
AATTAAGGAATGAGGTAGGAAGAGGCACTTTTAATCTGGAGGAAGAAATAAATGGAAGACTGTAATAGGAAAAATACAGGTCTAGGAAAAAAATAATTTT
TTTCCTTTGATGCTGGCCAAGGACCCCTCTACATAATACAGTTCTCCTGCTGGAAAGCATCAGGGCAAACAGAGTTATTCCAAACTCTGCAACAGGGAAG
ACTGTACTTTGACCTTCTTTTCCTGGGGAAAGGGAACAACTAGTAATCTTTAAATGTCAAAACTTTTCTTCTAAATAGTACATTCATTAACCAGTTTCTT
CTGGTGGTGCAAAGAACACTCACCACAGTGAGCAATACCACTATTCAATTTCCCCTTTGGAGAGGTGACAGCGGGGTAGAATCACCTGGAGTCAGCTGCT
AGTCTTTAACTGATGACAAGGCCTTGCAAATACCCCTGAGAACAATTTCACTCTGAGCTCACAGGGAAGCAGCAGTCTGGTGTGGGCTCCTGTGGTGTAA
CCATCAAATGTGGAAGACCTGATGGTGTTAGTGTGTGGGGATGCCGGGCTGAAATTCAACAGCCTTGCAAAAAGAAAGGGAAGATGGGATGTGTTAATAT
TGTAGTGGCATGCACTTTCCAGCTCTCCATGGAGCTCTCTTTATATATGAGGTAATTGAATGTCACTATTCTGTACCATACAGCAGGTATTATCTAGCCA
AGGTTATAATTACCATGAAGTGCTGTGGAATGTAGTAGGAGGCTTTTCACTGGG
  • BID.u.f.10 (forward primer)
  • BID.u.r.14 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP
PRLEGGQQRFQPQG*VHHKPTGVWLPPKLF*QQL
PQRAGRTGPRAASAGSPVGGLR*AAD*WQPQQP
LPLGKNR
DSESQEDIIRNIARHLAQVGDSMDRS
IPPGLVNGLALQLRNTSRSEEDRNRDLATALEQL
LQAYPRDMEKEKTMLVLALLLAKKVASHTPSLL
RDVFHTTVNFINQNLRTYVRSLARNGMD*TDSS
RSVTG*SSMWSQLYSCFQCRRSPGMSTAFLEKTG
WKIAVTSILKTMLNL*PTLKYLH*YT*MKMSIY
TYLNGLHIIHT*ICTSVNLHTVPLFPLCRFPLK
N*IGKQVSRK*KQNTIFLVKKNYCLLKYNHRGWS
YSRQYPV*GKQESEKEHTPYK*KIPLKIGTIYL
NTKEPTIFLFKKPHGTEILN*SAALK*WEVRPQ
YTGA*LFQLRFLCWSQKEPLVVLKGVKVI*GPRS
ATVCLQNQVTNCIHFFSFHDIKTLLKT*SHGCQ
KLLRCPGS*PPGNSCKLPISSHTLSSSMPQKCI
WREQVSKHKR*KSSWTF*KFSKVVPSLRDSQNQV
T*VVPK*IRKSLALETVQHWSAVPVVSYVPGIS
LKARQWMLGPYHTHCCEQETPVTTT*GHWRRI*
VRALTDS*FLLTRCFPVL*EFKIIRKEKQTLYCS
ACNTYHARAGSIESGQKLTNTKKKCCRAVWRPL
FGNKSS*HYDFSCFGVDF*KSFPTTMETG*TTL
RLHIHPYVSHYNQILTGGGIFFPKELYAVITRN*
WESVLKQQVTLDHLSHTLTLPQHLHLLLFHLNS
YSRPPFYNRS*CKFFQTKSEIVLVVKQDRHPFS
QSQHYKKIPLSQTQMFQS*ALPSHGDSGISWQLV
DFAL*HNPCGYDSKVTLIQRMCFPFCFKNI*IK
*WKFFC*TSKAFSLKRCLVYLKVTWDIWCIQKV
KSFLTSPLRTQH*LLRYSRLP*RITALAPSFTVQ
QLY*LC*LRIGI*SPLNVTILFSKPGVKPIKYG
LNKDN**CEMIPPVKGIVTMWIER*VH*LSSNP
MYSL*HVASDRKNNSQI*SLFLSPDEE*IGQKVD
DRKEEEPE*PTVISSAVQSGSAEAHGTHTEKGN
TCCLKCTIT*LSKLPFNSGIFEMKAFEPTLN*P
*LRNEVGRGTFNLEEEINGRL**EKYRSRKKIIF
FL*CWPRTPLHNTVLLLESIRANRVIPNSATGK
TVL*PSFPGEREQLVIFKCQNFSSK*YIH*PVS
SGGAKNTHHSEQYHYSISPLER*QRGRITWSQLL
VFN**QGLANTPENNFTLSSQGSSSLVWAPVV*
PSNVEDLMVLVCGDAGLKFNSLAKRKGRWDVLI
L*WHALSSSPWSSLYI*GN*MSLFCTIQQVLSSQ
GYNYHEVLWNVVGGFSL

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP
RGWRVVNNGSSLRDECITNLLVFGFLQSCSDNS
FRRELDALGHELPVLAPQWEGYDELQTDGNRSSH
SRLGRIE
ILKVKKTSSGILPGTSPRSGTAWTVA
SLRAW*TAWPCSSGTPAGRRRTGTGTWPLPWSS
CCRPTLETWRRRRPCWCWPCCWPRRWPVTRRPCS
VMSFTQQ*ILLTRTYAPT*GA*PEMGWTERTVP
EV*LAKARCGHSCIAASSVDGALACQQRS*RRQ
AGR*L*LLF*RQC*TYNPL*NIYINILE*KCPFT
RI*MAFISSTHESAHL*IYTRCLYFHCAGSHLK
IKLESRFQGSRNKIQFFW*KKITVY*STTIEDG
LTAGSILFEESKNQRRNIPLTNEKFHSK*GLSIL
ILRNQQSSCLKNHMAQRF*TKVLHSNDGKSGPS
TQGLDFFNFVSFVGVKKNHLWF*KV*R*FKGPG
QPLFVYKIR*LTAYTFSLSMTSRLC*RHEATGAR
SYCDAPGVSPLVIAVNFQFLAIRSAHPCLRSAS
GENRFLSIKDERAVGLFKNSAKWFPLLGTVKTK
SLR*YQNK*GKA*L*KQCNTGLLFQW*AMSQESV
*KHDSGCWVHITHIAVNRKLL*PQHEATGDAYE
*GH*RTHDFFLPDAFLFFKSLKSSERKNKLYIV
QHAIHTTLGLAQLKVGKSLQILKRSAAAQCGGHC
LEINLPNTTTFHVLEWTFKKVFQPQWKQVEPHC
AYTSIHTSAIIIRFSLGEAFSSQRSCMQSSPGT
NGKVFLSSK*LWTTSLTH*LFHSIFTCFCFT*IH
TVGHHFITGLSVNSSRPSLR*SWL*SKTVTPSP
KANIIKRFHCLKHKCSSLEHFPAMVTRAYPGSW
WILPCNTILVDMIQR*L*FRECVFLSVLKIFELS
DGNSFVKHQKLSP*KDAWCI*KSRGTFGAFRRS
NHS*PLLLGPSINCCDTQGFLKGSQHWRLVLLS
SNFISCAS*ELEYRVL*MLRSCFQNLESNQLSMD
LTKTIDDVK*YHLSRA*LPCG*KDESTDYLQIP
CILSSTLLLTERITHRFEVCSFPLMKSRLAKR*
MTGRKRSQNDPQ*SVQQCRAAVQRLMELTRKKET
HAA*NAR*LNYPNYHSIPVFLR*KHLSQH*IDL
N*GMR*EEALLIWRKK*MEDCNRKNTGLGKK*F
FSFDAGQGPLYIIQFSCWKASGQTELFQTLQQGR
LYFDLLFLGKGNN**SLNVKTFLLNSTFINQFL
LVVQRTLTTVSNTTIQFPLWRGDSGVESPGVSC
*SLTDDKALQIPLRTISL*AHREAAVWCGLLWCN
HQMWKT*WC*CVGMPG*NSTALQKEREDGMC*Y
CSGMHFPALHGALFIYEVIECHYSVPYSRYYLA
KVIITMKCCGM**EAFHW

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP
AAGGWSTTVPASGMSASQTYWCLASSKAVLTTA
SAESWTHWATSCQCWLPSGRATMSCRLMATAAA
TPAWEE*R
F*KSRRHHPEYCQAPRPGRGQHGP*H
PSGPGERPGPAAQEHQPVGGGPEQGPGHCPGAA
AAGLP*RHGEGEDHAGAGPAAGQEGGQSHAVLA
P*CLSHNSEFY*PEPTHLREELSQKWDGLNGQFQ
KCDWLKLDVVTAV*LLPV*TEPWHVNSVPREDR
LEDSCDFYFKDNVKLITHFKISTLIYLNENVHL
HVFEWPSYHPHMNLHICKSTHGAFISTVQVPT*K
LNWKAGFKEVETKYNFFGKKKLLFIKVQP*RMV
LQQAVSCLRKARIREGTYPLQMKNSTQNRDYLS
*Y*GTNNLPV*KTTWHRDSELKCCTQMMGSPAPV
HRGLTFSTSFPLLESKRTTCGSKRCEGDLRAQV
SHCLFTKSGN*LHTLFLFP*HQDFAKDMKPRVP
EATAMPRELAPW**L*TSNF*PYAQLIHASEVHL
ERTGF*A*KMKEQLDFLKIQQSGSLS*GQSKPS
HLGSTKINKEKLSFRNSATLVCCSSGKLCPRNQ
FKSTTVDAGSISHTLL*TGNSCDHNMRPLETHMS
KGTDGLMISSYQMLSCSLRV*NHQKGKTNSILF
SMQYIPR*GWLN*KWAKAYKY*KEVLPRSVEAT
VWK*IFLTLRLFMFWSGLLKKFSNHNGNRLNHTA
PTHPSIRQPL*SDSHWGRHFLPKGAVCSHHPEL
MGKCS*AASDSGPPLSHTDSSTASSPASVSLEF
IQ*ATIL*QVLV*ILPDQV*DSLGCKARPSPLLP
KPTL*KDSIVSNTNVPVLSTSQPW*LGHILAVG
GFCPVTQSLWI*FKGDFNSENVFSFLF*KYLN*
VMEILLLNIKSFLLEKMLGVSESHVGHLVHSEGQ
IIPDLSS*DPALTAAILKASLKDHSTGA*FYCP
ATLLVVLAENWNIESFECYDLVFKTWSQTN*VW
T*QRQLMM*NDTTCQGHSYHVDRKMSPLIIFKSH
VFSLARCF*QKE*LTDLKFVPFP**RVDWPKGR
*QEGRGARMTHSDQFSSAERQCRGSWNSHGKRK
HMLLKMHDNLIIQITIQFRYF*DESI*ANTKLTL
IKE*GRKRHF*SGGRNKWKTVIGKIQV*EKNNF
FPLMLAKDPST*YSSPAGKHQGKQSYSKLCNRE
DCTLTFFSWGKGTTSNL*MSKLFF*IVHSLTSFF
WWCKEHSPQ*AIPLFNFPFGEVTAG*NHLESAA
SL*LMTRPCKYP*EQFHSELTGKQQSGVGSCGV
TIKCGRPDGVSVWGCRAEIQQPCKKKGKMGCVNI
VVACTFQLSMELSLYMR*LNVTILYHTAGII*P
RL*LP*SAVECSRRLFTG

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