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Sequences

Sequence BID.jAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC CGCGGCTGGAGGGTGGTCGCCACTGGGACACTGTGAACCAGGAGTGAGTCGGAGCTGCCGCGCTGCCCAGGCCATGGACTGTGAGATTCTGAAAGTCAAG AAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTGAACGGCCTGGCCCTGCAGCT CAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGGAGAAGGAGAAG ACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACAACAGTGAATTTTATTAACC AGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGATGTGGTCACAGCT GTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTGTGACTTCTATTTTAAAGACAATG TTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACA ACATGAGGCCACTGGAGACGCATATGAGTAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCA GAAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAA GTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAAATAAATCTTCCTAACACTACGACTTTTCATGTTTTGGAGTGGACTTTTAAAAAAGTTTTCCAACC ACAATGGAAACAGGTTGAACCACACTGCGCCTACACATCCATCCATACGTCAGCCATTATAATCAGATTCTCACTGGGGGAGGCATTTTCTTCCCAAAGG AGCTGTATGCAGTCATCACCCGGAACTAATGGGAAAGTGTTCTTAAGCAGCAAGTGACTCTGGACCACCTCTCTCACACACTGACTCTTCCACAGCATCT TCACCTGCTTCTGTTTCACTTGAATTCATACAGTAGGCCACCATTTTATAACAGGTCTTAGTGTAAATTCTTCCAGACCAAGTCTGAGATAGTCTTGGTT GTAAAGCAAGACCGTCACCCCTTCTCCCAAAGCCAACATTATAAAAAGATTCCATTGTCTCAAACACAAATGTTCCAGTCTTGAGCACTTCCCAGCCATG GTGACTCGGGCATATCCTGGCAGTTGGTGGATTTTGCCCTGTAACACAATCCTTGTGGATATGATTCAAAGGTGACTTTAATTCAGAGAATGTGTTTTCC TTTCTGTTTTAAAAATATTTGAATTAAGTGATGGAAATTCTTTTGTTAAACATCAAAAGCTTTCTCCTTGAAAAGATGCTTGGTGTATCTGAAAGTCACG TGGGACATTTGGTGCATTCAGAAGGTCAAATCATTCCTGACCTCTCCTCTTAGGACCCAGCATTAACTGCTGCGATACTCAAGGCTTCCTTAAAGGATCA CAGCACTGGCGCCTAGTTTTACTGTCCAGCAACTTTATTAGTTGTGCTAGCTGAGAATTGGAATATAGAGTCCTTTGAATGTTACGATCTTGTTTTCAAA ACCTGGAGTCAAACCAATTAAGTATGGACTTAACAAAGACAATTGATGATGTGAAATGATACCACCTGTCAAGGGCATAGTTACCATGTGGATAGAAAGA TGAGTCCACTGATTATCTTCAAATCCCATGTATTCTCTCTAGCACGTTGCTTCTGACAGAAAGAATAACTCACAGATTTGAAGTTTGTTCCTTTCCCCTG ATGAAGAGTAGATTGGCCAAAAGGTAGATGACAGGAAGGAAGAGGAGCCAGAATGACCCACAGTGATCAGTTCAGCAGTGCAGAGCGGCAGTGCAGAGGC TCATGGAACTCACACGGAAAAAGGAAACACATGCTGCTTAAAATGCACGATAACTTAATTATCCAAATTACCATTCAATTCCGGTATTTTTGAGATGAAA GCATTTGAGCCAACACTAAATTGACCTTAATTAAGGAATGAGGTAGGAAGAGGCACTTTTAATCTGGAGGAAGAAATAAATGGAAGACTGTAATAGGAAA AATACAGGTCTAGGAAAAAAATAATTTTTTTCCTTTGATGCTGGCCAAGGACCCCTCTACATAATACAGTTCTCCTGCTGGAAAGCATCAGGGCAAACAG AGTTATTCCAAACTCTGCAACAGGGAAGACTGTACTTTGACCTTCTTTTCCTGGGGAAAGGGAACAACTAGTAATCTTTAAATGTCAAAACTTTTCTTCT AAATAGTACATTCATTAACCAGTTTCTTCTGGTGGTGCAAAGAACACTCACCACAGTGAGCAATACCACTATTCAATTTCCCCTTTGGAGAGGTGACAGC GGGGTAGAATCACCTGGAGTCAGCTGCTAGTCTTTAACTGATGACAAGGCCTTGCAAATACCCCTGAGAACAATTTCACTCTGAGCTCACAGGGAAGCAG CAGTCTGGTGTGGGCTCCTGTGGTGTAACCATCAAATGTGGAAGACCTGATGGTGTTAGTGTGTGGGGATGCCGGGCTGAAATTCAACAGCCTTGCAAAA AGAAAGGGAAGATGGGATGTGTTAATATTGTAGTGGCATGCACTTTCCAGCTCTCCATGGAGCTCTCTTTATATATGAGGTAATTGAATGTCACTATTCT GTACCATACAGCAGGTATTATCTAGCCAAGGTTATAATTACCATGAAGTGCTGTGGAATGTAGTAGGAGGCTTTTCACTGGG

BID.u.f.10 (forward primer)
BID.u.r.14 (reverse primer)
Mutually exclusive exon skipping

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP PRLEGGRHWDTVNQE*VGAAALPRPWTVRF*KSR RHHPEYCQAPRPGRGQHGP*HPSGPGERPGPAA QEHQPVGGGPEQGPGHCPGAAAAGLP*RHGEGE DHAGAGPAAGQEGGQSHAVLAP*CLSHNSEFY*P EPTHLREELSQKWDGLNGQFQKCDWLKLDVVTA V*LLPV*TEPWHVNSVPREDRLEDSCDFYFKDN VKLITHFKISTLIYLNENVHITHIAVNRKLL*PQ HEATGDAYE*GH*RTHDFFLPDAFLFFKSLKSS ERKNKLYIVQHAIHTTLGLAQLKVGKSLQILKR SAAAQCGGHCLEINLPNTTTFHVLEWTFKKVFQP QWKQVEPHCAYTSIHTSAIIIRFSLGEAFSSQR SCMQSSPGTNGKVFLSSK*LWTTSLTH*LFHSI FTCFCFT*IHTVGHHFITGLSVNSSRPSLR*SWL *SKTVTPSPKANIIKRFHCLKHKCSSLEHFPAM VTRAYPGSWWILPCNTILVDMIQR*L*FRECVF LSVLKIFELSDGNSFVKHQKLSP*KDAWCI*KSR GTFGAFRRSNHS*PLLLGPSINCCDTQGFLKGS QHWRLVLLSSNFISCAS*ELEYRVL*MLRSCFQ NLESNQLSMDLTKTIDDVK*YHLSRA*LPCG*KD ESTDYLQIPCILSSTLLLTERITHRFEVCSFPL MKSRLAKR*MTGRKRSQNDPQ*SVQQCRAAVQR LMELTRKKETHAA*NAR*LNYPNYHSIPVFLR*K HLSQH*IDLN*GMR*EEALLIWRKK*MEDCNRK NTGLGKK*FFSFDAGQGPLYIIQFSCWKASGQT ELFQTLQQGRLYFDLLFLGKGNN**SLNVKTFLL NSTFINQFLLVVQRTLTTVSNTTIQFPLWRGDS GVESPGVSC*SLTDDKALQIPLRTISL*AHREA AVWCGLLWCNHQMWKT*WC*CVGMPG*NSTALQK EREDGMC*YCSGMHFPALHGALFIYEVIECHYS VPYSRYYLAKVIITMKCCGM**EAFHW

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP RGWRVVATGTL*TRSESELPRCPGHGL*DSESQ EDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQL RNTSRSEEDRNRDLATALEQLLQAYPRDMEKEK TMLVLALLLAKKVASHTPSLLRDVFHTTVNFIN QNLRTYVRSLARNGMD*TDSSRSVTG*SSMWSQL YSCFQCRRSPGMSTAFLEKTGWKIAVTSILKTM LNL*PTLKYLH*YT*MKMSISHTLL*TGNSCDH NMRPLETHMSKGTDGLMISSYQMLSCSLRV*NHQ KGKTNSILFSMQYIPR*GWLN*KWAKAYKY*KE VLPRSVEATVWK*IFLTLRLFMFWSGLLKKFSN HNGNRLNHTAPTHPSIRQPL*SDSHWGRHFLPKG AVCSHHPELMGKCS*AASDSGPPLSHTDSSTAS SPASVSLEFIQ*ATIL*QVLV*ILPDQV*DSLG CKARPSPLLPKPTL*KDSIVSNTNVPVLSTSQPW *LGHILAVGGFCPVTQSLWI*FKGDFNSENVFS FLF*KYLN*VMEILLLNIKSFLLEKMLGVSESH VGHLVHSEGQIIPDLSS*DPALTAAILKASLKDH STGA*FYCPATLLVVLAENWNIESFECYDLVFK TWSQTN*VWT*QRQLMM*NDTTCQGHSYHVDRK MSPLIIFKSHVFSLARCF*QKE*LTDLKFVPFP* *RVDWPKGR*QEGRGARMTHSDQFSSAERQCRG SWNSHGKRKHMLLKMHDNLIIQITIQFRYF*DE SI*ANTKLTLIKE*GRKRHF*SGGRNKWKTVIGK IQV*EKNNFFPLMLAKDPST*YSSPAGKHQGKQ SYSKLCNREDCTLTFFSWGKGTTSNL*MSKLFF *IVHSLTSFFWWCKEHSPQ*AIPLFNFPFGEVTA G*NHLESAASL*LMTRPCKYP*EQFHSELTGKQ QSGVGSCGVTIKCGRPDGVSVWGCRAEIQQPCK KKGKMGCVNIVVACTFQLSMELSLYMR*LNVTIL YHTAGII*PRL*LP*SAVECSRRLFTG

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP AAGGWSPLGHCEPGVSRSCRAAQAMDCEILKVK KTSSGILPGTSPRSGTAWTVASLRAW*TAWPCS SGTPAGRRRTGTGTWPLPWSSCCRPTLETWRRRR PCWCWPCCWPRRWPVTRRPCSVMSFTQQ*ILLT RTYAPT*GA*PEMGWTERTVPEV*LAKARCGHS CIAASSVDGALACQQRS*RRQAGR*L*LLF*RQC *TYNPL*NIYINILE*KCPYHTHCCEQETPVTT T*GHWRRI*VRALTDS*FLLTRCFPVL*EFKII RKEKQTLYCSACNTYHARAGSIESGQKLTNTKKK CCRAVWRPLFGNKSS*HYDFSCFGVDF*KSFPT TMETG*TTLRLHIHPYVSHYNQILTGGGIFFPK ELYAVITRN*WESVLKQQVTLDHLSHTLTLPQHL HLLLFHLNSYSRPPFYNRS*CKFFQTKSEIVLV VKQDRHPFSQSQHYKKIPLSQTQMFQS*ALPSH GDSGISWQLVDFAL*HNPCGYDSKVTLIQRMCFP FCFKNI*IK*WKFFC*TSKAFSLKRCLVYLKVT WDIWCIQKVKSFLTSPLRTQH*LLRYSRLP*RI TALAPSFTVQQLY*LC*LRIGI*SPLNVTILFSK PGVKPIKYGLNKDN**CEMIPPVKGIVTMWIER *VH*LSSNPMYSL*HVASDRKNNSQI*SLFLSP DEE*IGQKVDDRKEEEPE*PTVISSAVQSGSAEA HGTHTEKGNTCCLKCTIT*LSKLPFNSGIFEMK AFEPTLN*P*LRNEVGRGTFNLEEEINGRL**E KYRSRKKIIFFL*CWPRTPLHNTVLLLESIRANR VIPNSATGKTVL*PSFPGEREQLVIFKCQNFSS K*YIH*PVSSGGAKNTHHSEQYHYSISPLER*Q RGRITWSQLLVFN**QGLANTPENNFTLSSQGSS SLVWAPVV*PSNVEDLMVLVCGDAGLKFNSLAK RKGRWDVLIL*WHALSSSPWSSLYI*GN*MSLF CTIQQVLSSQGYNYHEVLWNVVGGFSL

Sequence BID.eAug05

GAAGGAGGAAGCGCGCGGGGCGCCATAAGGAGGAAGCGGGTAGTCGACCGTGTCCGCGCGCCTGGGAGACGCTGCCTCGGCCCGGACGCGCCCGCGCCCC CGCGGCTGGAGGGTGGTCAACAACGGTTCCAGCCTCAGGGATGAGTGCATCACAAACCTACTGGTGTTTGGCTTCCTCCAAAGCTGTTCTGACAACAGCT TCCGCAGAGAGCTGGACGCACTGGGCCACGAGCTGCCAGTGCTGGCTCCCCAGTGGGAGGGCTACGATGAGCTGCAGACTGATGGCAACCGCAGCAGCCA CTCCCGCTTGGGAAGAATAGAGGCAGATTCTGAAAGTCAAGAAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGT AGCATCCCTCCGGGCCTGGTGAACGGCCTGGCCCTGCAGCTCAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGC AGCTGCTGCAGGCCTACCCTAGAGACATGGAGAAGGAGAAGACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTT GCTCCGTGATGTCTTTCACACAACAGTGAATTTTATTAACCAGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGT TCCAGAAGTGTGACTGGCTAAAGCTCGATGTGGTCACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGA CAGGCTGGAAGATAGCTGTGACTTCTATTTTAAAGACAATGTTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCAT TTACACGTATTTGAATGGCCTTCATATCATCCACACATGAATCTGCACATCTGTAAATCTACACACGGTGCCTTTATTTCCACTGTGCAGGTTCCCACTT AAAAATTAAATTGGAAAGCAGGTTTCAAGGAAGTAGAAACAAAATACAATTTTTTTGGTAAAAAAAAATTACTGTTTATTAAAGTACAACCATAGAGGAT GGTCTTACAGCAGGCAGTATCCTGTTTGAGGAAAGCAAGAATCAGAGAAGGAACATACCCCTTACAAATGAAAAATTCCACTCAAAATAGGGACTATCTA TCTTAATACTAAGGAACCAACAATCTTCCTGTTTAAAAAACCACATGGCACAGAGATTCTGAACTAAAGTGCTGCACTCAAATGATGGGAAGTCCGGCCC CAGTACACAGGGGCTTGACTTTTTCAACTTCGTTTCCTTTGTTGGAGTCAAAAAGAACCACTTGTGGTTCTAAAAGGTGTGAAGGTGATTTAAGGGCCCA GGTCAGCCACTGTTTGTTTACAAAATCAGGTAACTAACTGCATACACTTTTTCTCTTTCCATGACATCAAGACTTTGCTAAAGACATGAAGCCACGGGTG CCAGAAGCTACTGCGATGCCCCGGGAGTTAGCCCCCTGGTAATAGCTGTAAACTTCCAATTTCTAGCCATACGCTCAGCTCATCCATGCCTCAGAAGTGC ATCTGGAGAGAACAGGTTTCTAAGCATAAAAGATGAAAGAGCAGTTGGACTTTTTAAAAATTCAGCAAAGTGGTTCCCTCTCTTAGGGACAGTCAAAACC AAGTCACTTAGGTAGTACCAAAATAAATAAGGAAAAGCTTAGCTTTAGAAACAGTGCAACACTGGTCTGCTGTTCCAGTGGTAAGCTATGTCCCAGGAAT CAGTTTAAAAGCACGACAGTGGATGCTGGGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACAACATGAGGCCACTGGAGACGCATA TGAGTAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCAGAAAGGAAAAACAAACTCTATATT GTTCAGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAAGTGCTGCCGCGCAGTGTGGAGGCC ACTGTTTGGAAATAAATCTTCCTAACACTACGACTTTTCATGTTTTGGAGTGGACTTTTAAAAAAGTTTTCCAACCACAATGGAAACAGGTTGAACCACA CTGCGCCTACACATCCATCCATACGTCAGCCATTATAATCAGATTCTCACTGGGGGAGGCATTTTCTTCCCAAAGGAGCTGTATGCAGTCATCACCCGGA ACTAATGGGAAAGTGTTCTTAAGCAGCAAGTGACTCTGGACCACCTCTCTCACACACTGACTCTTCCACAGCATCTTCACCTGCTTCTGTTTCACTTGAA TTCATACAGTAGGCCACCATTTTATAACAGGTCTTAGTGTAAATTCTTCCAGACCAAGTCTGAGATAGTCTTGGTTGTAAAGCAAGACCGTCACCCCTTC TCCCAAAGCCAACATTATAAAAAGATTCCATTGTCTCAAACACAAATGTTCCAGTCTTGAGCACTTCCCAGCCATGGTGACTCGGGCATATCCTGGCAGT TGGTGGATTTTGCCCTGTAACACAATCCTTGTGGATATGATTCAAAGGTGACTTTAATTCAGAGAATGTGTTTTCCTTTCTGTTTTAAAAATATTTGAAT TAAGTGATGGAAATTCTTTTGTTAAACATCAAAAGCTTTCTCCTTGAAAAGATGCTTGGTGTATCTGAAAGTCACGTGGGACATTTGGTGCATTCAGAAG GTCAAATCATTCCTGACCTCTCCTCTTAGGACCCAGCATTAACTGCTGCGATACTCAAGGCTTCCTTAAAGGATCACAGCACTGGCGCCTAGTTTTACTG TCCAGCAACTTTATTAGTTGTGCTAGCTGAGAATTGGAATATAGAGTCCTTTGAATGTTACGATCTTGTTTTCAAAACCTGGAGTCAAACCAATTAAGTA TGGACTTAACAAAGACAATTGATGATGTGAAATGATACCACCTGTCAAGGGCATAGTTACCATGTGGATAGAAAGATGAGTCCACTGATTATCTTCAAAT CCCATGTATTCTCTCTAGCACGTTGCTTCTGACAGAAAGAATAACTCACAGATTTGAAGTTTGTTCCTTTCCCCTGATGAAGAGTAGATTGGCCAAAAGG TAGATGACAGGAAGGAAGAGGAGCCAGAATGACCCACAGTGATCAGTTCAGCAGTGCAGAGCGGCAGTGCAGAGGCTCATGGAACTCACACGGAAAAAGG AAACACATGCTGCTTAAAATGCACGATAACTTAATTATCCAAATTACCATTCAATTCCGGTATTTTTGAGATGAAAGCATTTGAGCCAACACTAAATTGA CCTTAATTAAGGAATGAGGTAGGAAGAGGCACTTTTAATCTGGAGGAAGAAATAAATGGAAGACTGTAATAGGAAAAATACAGGTCTAGGAAAAAAATAA TTTTTTTCCTTTGATGCTGGCCAAGGACCCCTCTACATAATACAGTTCTCCTGCTGGAAAGCATCAGGGCAAACAGAGTTATTCCAAACTCTGCAACAGG GAAGACTGTACTTTGACCTTCTTTTCCTGGGGAAAGGGAACAACTAGTAATCTTTAAATGTCAAAACTTTTCTTCTAAATAGTACATTCATTAACCAGTT TCTTCTGGTGGTGCAAAGAACACTCACCACAGTGAGCAATACCACTATTCAATTTCCCCTTTGGAGAGGTGACAGCGGGGTAGAATCACCTGGAGTCAGC TGCTAGTCTTTAACTGATGACAAGGCCTTGCAAATACCCCTGAGAACAATTTCACTCTGAGCTCACAGGGAAGCAGCAGTCTGGTGTGGGCTCCTGTGGT GTAACCATCAAATGTGGAAGACCTGATGGTGTTAGTGTGTGGGGATGCCGGGCTGAAATTCAACAGCCTTGCAAAAAGAAAGGGAAGATGGGATGTGTTA ATATTGTAGTGGCATGCACTTTCCAGCTCTCCATGGAGCTCTCTTTATATATGAGGTAATTGAATGTCACTATTCTGTACCATACAGCAGGTATTATCTA GCCAAGGTTATAATTACCATGAAGTGCTGTGGAATGTAGTAGGAGGCTTTTCACTGGG

BID.u.f.10 (forward primer)
BID.u.r.14 (reverse primer)
Mutually exclusive exon skipping

Frame 0

EGGSARGAIRRKRVVDRVRAPGRRCLGPDAPAP PRLEGGQQRFQPQG*VHHKPTGVWLPPKLF*QQL PQRAGRTGPRAASAGSPVGGLR*AAD*WQPQQP LPLGKNRGRF*KSRRHHPEYCQAPRPGRGQHGP *HPSGPGERPGPAAQEHQPVGGGPEQGPGHCPGA AAAGLP*RHGEGEDHAGAGPAAGQEGGQSHAVL AP*CLSHNSEFY*PEPTHLREELSQKWDGLNGQ FQKCDWLKLDVVTAV*LLPV*TEPWHVNSVPRED RLEDSCDFYFKDNVKLITHFKISTLIYLNENVH LHVFEWPSYHPHMNLHICKSTHGAFISTVQVPT *KLNWKAGFKEVETKYNFFGKKKLLFIKVQP*RM VLQQAVSCLRKARIREGTYPLQMKNSTQNRDYL S*Y*GTNNLPV*KTTWHRDSELKCCTQMMGSPA PVHRGLTFSTSFPLLESKRTTCGSKRCEGDLRAQ VSHCLFTKSGN*LHTLFLFP*HQDFAKDMKPRV PEATAMPRELAPW**L*TSNF*PYAQLIHASEV HLERTGF*A*KMKEQLDFLKIQQSGSLS*GQSKP SHLGSTKINKEKLSFRNSATLVCCSSGKLCPRN QFKSTTVDAGSISHTLL*TGNSCDHNMRPLETH MSKGTDGLMISSYQMLSCSLRV*NHQKGKTNSIL FSMQYIPR*GWLN*KWAKAYKY*KEVLPRSVEA TVWK*IFLTLRLFMFWSGLLKKFSNHNGNRLNH TAPTHPSIRQPL*SDSHWGRHFLPKGAVCSHHPE LMGKCS*AASDSGPPLSHTDSSTASSPASVSLE FIQ*ATIL*QVLV*ILPDQV*DSLGCKARPSPL LPKPTL*KDSIVSNTNVPVLSTSQPW*LGHILAV GGFCPVTQSLWI*FKGDFNSENVFSFLF*KYLN *VMEILLLNIKSFLLEKMLGVSESHVGHLVHSE GQIIPDLSS*DPALTAAILKASLKDHSTGA*FYC PATLLVVLAENWNIESFECYDLVFKTWSQTN*V WT*QRQLMM*NDTTCQGHSYHVDRKMSPLIIFK SHVFSLARCF*QKE*LTDLKFVPFP**RVDWPKG R*QEGRGARMTHSDQFSSAERQCRGSWNSHGKR KHMLLKMHDNLIIQITIQFRYF*DESI*ANTKL TLIKE*GRKRHF*SGGRNKWKTVIGKIQV*EKNN FFPLMLAKDPST*YSSPAGKHQGKQSYSKLCNR EDCTLTFFSWGKGTTSNL*MSKLFF*IVHSLTS FFWWCKEHSPQ*AIPLFNFPFGEVTAG*NHLESA ASL*LMTRPCKYP*EQFHSELTGKQQSGVGSCG VTIKCGRPDGVSVWGCRAEIQQPCKKKGKMGCV NIVVACTFQLSMELSLYMR*LNVTILYHTAGII* PRL*LP*SAVECSRRLFTG

Frame 1

KEEARGAP*GGSG*STVSARLGDAASARTRPRP RGWRVVNNGSSLRDECITNLLVFGFLQSCSDNS FRRELDALGHELPVLAPQWEGYDELQTDGNRSSH SRLGRIEADSESQEDIIRNIARHLAQVGDSMDR SIPPGLVNGLALQLRNTSRSEEDRNRDLATALE QLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSL LRDVFHTTVNFINQNLRTYVRSLARNGMD*TDS SRSVTG*SSMWSQLYSCFQCRRSPGMSTAFLEK TGWKIAVTSILKTMLNL*PTLKYLH*YT*MKMSI YTYLNGLHIIHT*ICTSVNLHTVPLFPLCRFPL KN*IGKQVSRK*KQNTIFLVKKNYCLLKYNHRG WSYSRQYPV*GKQESEKEHTPYK*KIPLKIGTIY LNTKEPTIFLFKKPHGTEILN*SAALK*WEVRP QYTGA*LFQLRFLCWSQKEPLVVLKGVKVI*GP RSATVCLQNQVTNCIHFFSFHDIKTLLKT*SHGC QKLLRCPGS*PPGNSCKLPISSHTLSSSMPQKC IWREQVSKHKR*KSSWTF*KFSKVVPSLRDSQN QVT*VVPK*IRKSLALETVQHWSAVPVVSYVPGI SLKARQWMLGPYHTHCCEQETPVTTT*GHWRRI *VRALTDS*FLLTRCFPVL*EFKIIRKEKQTLY CSACNTYHARAGSIESGQKLTNTKKKCCRAVWRP LFGNKSS*HYDFSCFGVDF*KSFPTTMETG*TT LRLHIHPYVSHYNQILTGGGIFFPKELYAVITR N*WESVLKQQVTLDHLSHTLTLPQHLHLLLFHLN SYSRPPFYNRS*CKFFQTKSEIVLVVKQDRHPF SQSQHYKKIPLSQTQMFQS*ALPSHGDSGISWQ LVDFAL*HNPCGYDSKVTLIQRMCFPFCFKNI*I K*WKFFC*TSKAFSLKRCLVYLKVTWDIWCIQK VKSFLTSPLRTQH*LLRYSRLP*RITALAPSFT VQQLY*LC*LRIGI*SPLNVTILFSKPGVKPIKY GLNKDN**CEMIPPVKGIVTMWIER*VH*LSSN PMYSL*HVASDRKNNSQI*SLFLSPDEE*IGQK VDDRKEEEPE*PTVISSAVQSGSAEAHGTHTEKG NTCCLKCTIT*LSKLPFNSGIFEMKAFEPTLN* P*LRNEVGRGTFNLEEEINGRL**EKYRSRKKI IFFL*CWPRTPLHNTVLLLESIRANRVIPNSATG KTVL*PSFPGEREQLVIFKCQNFSSK*YIH*PV SSGGAKNTHHSEQYHYSISPLER*QRGRITWSQ LLVFN**QGLANTPENNFTLSSQGSSSLVWAPVV *PSNVEDLMVLVCGDAGLKFNSLAKRKGRWDVL IL*WHALSSSPWSSLYI*GN*MSLFCTIQQVLS SQGYNYHEVLWNVVGGFSL

Frame 2

RRKRAGRHKEEAGSRPCPRAWETLPRPGRARAP AAGGWSTTVPASGMSASQTYWCLASSKAVLTTA SAESWTHWATSCQCWLPSGRATMSCRLMATAAA TPAWEE*RQILKVKKTSSGILPGTSPRSGTAWTV ASLRAW*TAWPCSSGTPAGRRRTGTGTWPLPWS SCCRPTLETWRRRRPCWCWPCCWPRRWPVTRRP CSVMSFTQQ*ILLTRTYAPT*GA*PEMGWTERTV PEV*LAKARCGHSCIAASSVDGALACQQRS*RR QAGR*L*LLF*RQC*TYNPL*NIYINILE*KCP FTRI*MAFISSTHESAHL*IYTRCLYFHCAGSHL KIKLESRFQGSRNKIQFFW*KKITVY*STTIED GLTAGSILFEESKNQRRNIPLTNEKFHSK*GLS ILILRNQQSSCLKNHMAQRF*TKVLHSNDGKSGP STQGLDFFNFVSFVGVKKNHLWF*KV*R*FKGP GQPLFVYKIR*LTAYTFSLSMTSRLC*RHEATG ARSYCDAPGVSPLVIAVNFQFLAIRSAHPCLRSA SGENRFLSIKDERAVGLFKNSAKWFPLLGTVKT KSLR*YQNK*GKA*L*KQCNTGLLFQW*AMSQE SV*KHDSGCWVHITHIAVNRKLL*PQHEATGDAY E*GH*RTHDFFLPDAFLFFKSLKSSERKNKLYI VQHAIHTTLGLAQLKVGKSLQILKRSAAAQCGG HCLEINLPNTTTFHVLEWTFKKVFQPQWKQVEPH CAYTSIHTSAIIIRFSLGEAFSSQRSCMQSSPG TNGKVFLSSK*LWTTSLTH*LFHSIFTCFCFT* IHTVGHHFITGLSVNSSRPSLR*SWL*SKTVTPS PKANIIKRFHCLKHKCSSLEHFPAMVTRAYPGS WWILPCNTILVDMIQR*L*FRECVFLSVLKIFE LSDGNSFVKHQKLSP*KDAWCI*KSRGTFGAFRR SNHS*PLLLGPSINCCDTQGFLKGSQHWRLVLL SSNFISCAS*ELEYRVL*MLRSCFQNLESNQLS MDLTKTIDDVK*YHLSRA*LPCG*KDESTDYLQI PCILSSTLLLTERITHRFEVCSFPLMKSRLAKR *MTGRKRSQNDPQ*SVQQCRAAVQRLMELTRKK ETHAA*NAR*LNYPNYHSIPVFLR*KHLSQH*ID LN*GMR*EEALLIWRKK*MEDCNRKNTGLGKK* FFSFDAGQGPLYIIQFSCWKASGQTELFQTLQQ GRLYFDLLFLGKGNN**SLNVKTFLLNSTFINQF LLVVQRTLTTVSNTTIQFPLWRGDSGVESPGVS C*SLTDDKALQIPLRTISL*AHREAAVWCGLLW CNHQMWKT*WC*CVGMPG*NSTALQKEREDGMC* YCSGMHFPALHGALFIYEVIECHYSVPYSRYYL AKVIITMKCCGM**EAFHW