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Sequences

Sequence ADAM9.bAug05

TAGGCGATGTCGGGAGCGAGCTCGGACCGAGGGCTCAGTTGCGTCAGTGCCGCGCGCGTGCTCGTCGGGCGCGCGTGCTCGTCGGGCGCGCGCGCTTCCC GGCCAGACTTGGGGCCCCGGCAGGGTTGGAAAATGATGGAAGAGGCGGAGGTGGAGGCGACCGAGTGCTGAGAGGAACCTGCGGAATCGGCCGAGATGGG GTCTGGCGCGCGCTTTCCCTCGGGGACCCTTCGTGTCCGGTGGTTGCTGTTGCTTGGCCTGGTGGGCCCAGTCCTCGGTGCGGCGCGGCCAGGCTTTCAA CAGACCTCACATCTTTCTTCTTATGAAATTATAACTCCTTGGAGATTAACTAGAGAAAGAAGAGAAGCCCCTAGGCCCTATTCAAAACAAGTATCTTATG TTATTCAGGCTGAAGGAAAAGAGCATATTATTCACTTGGAAAGGAACAAAGACCTTTTGCCTGAAGATTTTGTGGTTTATACTTACAACAAGGAAGGGAC TTTAATCACTGACCATCCCAATATACAGAATCATTGTCATTATCGGGGCTATGTGGAGGGAGTTCATAATTCATCCATTGCTCTTAGCGACTGTTTTGGA CTCAGAGGATTGCTGCATTTAGAGAATGCGAGTTATGGGATTGAACCCCTGCAGAACAGCTCTCATTTTGAGCACATCATTTATCGAATGGATGATGTCT ACAAAGAGCCTCTGAAATGTGGAGTTTCCAACAAGGATATAGAGAAAGAAACTGCAAAGGATGAAGAGGAAGAGCCTCCCAGCATGACTCAGCTACTTCG AAGAAGAAGAGCTGTCTTGCCACAGACCCGGTATGTGGAGCTGTTCATTGTCGTAGACAAGGAAAGGTATGACATGATGGGAAGAAATCAGACTGCTGTG AGAGAAGAGATGATTCTCCTGGCAAACTACTTGGATAGTATGTATATTATGTTAAATATTCGAATTGTGCTAGTTGGACTGGAGATTTGGACCAATGGAA ACCTGATCAACATAGTTGGGGGTGCTGGTGATGTGCTGGGGAACTTCGTGCAGTGGCGGGAAAAGTTTCTTATCACACGTCGGAGACATGACAGTGCACA GCTAGTTCTAAAGAAAGGTTTTGGTGGAACTGCAGGAATGGCATTTGTGGGAACAGTGTGTTCAAGGAGCCACGCAGGCGGGATTAATGTGTTTGGACAA ATCACTGTGGAGACATTTGCTTCCATTGTTGCTCATGAATTGGGTCATAATCTTGGAATGAATCACGATGATGGGAGAGATTGTTCCTGTGGAGCAAAGA GCTGCATCATGAATTCAGGAGCATCGGGTTCCAGAAACTTTAGCAGTTGCAGTGCAGAGGACTTTGAGAAGTTAACTTTAAATAAAGGAGGAAACTGCCT TCTTAATATTCCAAAGCCTGATGAAGCCTATAGTGCTCCCTCCTGTGGTAATAAGTTGGTGGACGCTGGGGAAGAGTGTGACTGTGGTACTCCAAAGGAA TGTGAATTGGACCCTTGCTGCGAAGGAAGTACCTGTAAGCTTAAATCATTTGCTGAGTGTGCATATGGTGACTGTTGTAAAGACTGTCGGTTCCTTCCAG GAGGTACTTTATGCCGAGGAAAAACCAGTGAGTGTGATGTTCCAGAGTACTGCAATGGTTCTTCTCAGTTCTGTCAGCCAGATGTTTTTATTCAGAATGG ATATCCTTGCCAGAATAACAAAGCCTATTGCTACAACGGCATGTGCCAGTATTATGATGCTCAATGTCAAGTCATCTTTGGCTCAAAAGCCAAGGCTGCC CCCAAAGATTGTTTCATTGAAGTGAATTCTAAAGGTGACAGATTTGGCAATTGTGGTTTCTCTGGCAATGAATACAAGAAGTGTGCCACTGGGAATGCTT TGTGTGGAAAGCTTCAGTGTGAGAATGTACAAGAGATACCTGTATTTGGAATTGTGCCTGCTATTATTCAAACGCCTAGTCGAGGCACCAAATGTTGGGG TGTGGATTTCCAGCTAGGATCAGATGTTCCAGATCCTGGGATGGTTAACGAAGGCACAAAATGTGGTGCTGGAAAGATCTGTAGAAACTTCCAGTGTGTA GATGCTTCTGTTCTGAATTATGACTGTGATGTTCAGAAAAAGTGTCATGGACATGGGAAATGAATACTGCATTGAGGGACGGACTTCTGGTCTTCTTCTT CCTAATTGTTCCCCTTATTGTCTGTGCTATTTTTATCTTCATCAAGAGGGATCAACTGTGGAGAAGCTACTTCAGAAAGAAGAGATCACAAACATATGAG TCAGATGGCAAAAATCAAGCAAACCCTTCTAGACAGCCGGGGAGTGTTCCTCGACATGTTTCTCCAGTGACACCTCCCAGAGAAGTTCCTATATATGCAA ACAGATTTGCAGTACCAACCTATGCAGCCAAGCAACCTCAGCAGTTCCCATCAAGGCCACCTCCACCACAACCGAAAGTATCATCTCAGGGAAACTTAAT TCCTGCCCGTCCTGCTCCTGCACCTCCTTTATATAGTTCCCTCACTTGATTTTTTTAACCTTCTTTTTGCAAATGTCTTCAGGGAACTGAGCTAATACTT TTTTTTTTTCTTGATGTTTTCTTGAAAAGCCTTTCTGTTGCAACTATGAATGAAAACAAAACACCACAAAACAGACTTCACTAACACAGAAAAACAGAAA CTGAGTGTGAGAGTTGTGAAATACAAGGAAATGCAGTAAAGCCAGGGAATTTACAATAACATTTCCGTTTCCATCATTGAATAAGTCTTATTCAGTCATC GGTGAGGTTAATGCACTAATCATGGATTTTTTGAACATGTTATTGCAGTGATTCTCAAATTAACTGTATTGGTGTAAGAGTTTTGTCATTAAGTGTTTAA GTGTTATTCTGAATTTTCTACCTTAGTTATCATTAATGTAGTTCCTCATTGAACATGTGATAATCTAATACCTGTGAAAACTGACTAATCAGCTGCCAAT AATATCTAATATTTTTCATCATGCACGAATTAATAATCATCATACTCTAGAATCTTGTCTGTCACTCACTACATGAATAAGCAAATATTGTCTTCAAAAG AATGCACAAGAACCACAATTAAGATGTCATATTATTTTGAAAGTACAAAATATACTAAAAGAGTGTGTGTGTATTCACGCAGTTACTCGCTTCCATTTTT ATGACCTTTCAACTATAGGTAATAACTCTTAGAGAAATTAATTTAATATTAGAATTTCTATTATGAATCATGTGAAAGCATGACATTCGTTCACAATAGC ACTATTTTAAATAAATTATAAGCTTTAAGGTACGAAGTATTTAATAGATCTAATCAAATATGTTGATTCATGGCTATAATAAAGCAGGAGCAATTATAAA ATCTTCAATCAATTGAACTTTTACAAAACCACTTGAGAATTTCATGAGCACTTTAAAATCTGAACTTTCAAAGCTTGCTATTAAATCATTTAGAATGTTT ACATTTACTAAGGTGTGCTGGGTCATGTAAAATATTAGACACTAATATTTTCATAGAAATTAGGCTGGAGAAAGAAGGAAGAAATGGTTTTCTTAAATAC CTACAAAAAAGTTACTGTGGTATCTATGAGTTATCATCTTAGCTGTGTTAAAAATGAATTTTTACTATGGCAGATATGGTATGGATCGTAAAATTTTAAG CACTAAAAATTTTTTCATAACCTTTCATAATAAAGTTTAATAATAGGTTTATTAACTGAATTTCATTAGTTTTTTAAAAGTGTTTTTGGTTTGTGTATAT ATACATATACAAATACAACATTTACAATAAATAAAATACTTGAAATTCTCTTTTGTGTCTCCTAGTAGCTTCCTACTCAACTATTTATAATCTCATTAAT TAAAAAGTTATAATTTTAGATAAAAATTCTAGTCAAATTTTTACAGATATTATCTCACTAATTTTCAGACTTTTGCCAAAGTGTGCACAATGGCTTTTTG TTAATAAAGAACAGATTAGTTTTGAAGAAGGCAAAAATTTCAGTTTTCTGAAGACAGCATGTTATTTTAACAATCAAGTATACATATTAAAAATTGTGAG CAATCTCAAATGAAGGTCCATCGTTTCATTTTAAATCTCTAAATGAATTCATATAAGACTCAAACGTTTGTGCTGTTCACTCATGTAGCCTCAGTTTTTG CAATTGTGATGCATATCACTGAAATTTTACAGTTGGTAATGTATTAACTATGTAACTTAACACTTGGAATTAAATAGTTCTTTGGATATTTGACTAGTTA AGTTTTTAAAAAGACTATTGGATCTGAACTTCTTTTATATATTTTTTAATATGCTTTATGTTTTTTACTTACTTGGTCATGGATGCCACTTCAAAATTTG AAAATATTAAAGGACATCCTTTCTTTCTTCAAAAAGAATAAATAAGGGT

ADAM9.F3 (forward primer)
ADAM9.R3 (reverse primer)
Single exon skipping

Frame 0

*AMSGASSDRGLSCVSAARVLVGRACSSGARAS RPDLGPRQGWKMMEEAEVEATEC*EEPAESAEMG SGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQ QTSHLSSYEIITPWRLTRERREAPRPYSKQVSY VIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGT LITDHPNIQNHCHYRGYVEGVHNSSIALSDCFG LRGLLHLENASYGIEPLQNSSHFEHIIYRMDDV YKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLR RRRAVLPQTRYVELFIVVDKERYDMMGRNQTAV REEMILLANYLDSMYIMLNIRIVLVGLEIWTNG NLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQ LVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQ ITVETFASIVAHELGHNLGMNHDDGRDCSCGAK SCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCL LNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKE CELDPCCEGSTCKLKSFAECAYGDCCKDCRFLP GGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNG YPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAA PKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNA LCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWG VDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCV DASVLNYDCDVQKKCHGHGK*ILH*GTDFWSSS S*LFPLLSVLFLSSSRGINCGEATSERRDHKHMS QMAKIKQTLLDSRGVFLDMFLQ*HLPEKFLYMQ TDLQYQPMQPSNLSSSHQGHLHHNRKYHLRET* FLPVLLLHLLYIVPSLDFFNLLFANVFRELS*YF FFFLMFS*KAFLLQL*MKTKHHKTDFTNTEKQK LSVRVVKYKEMQ*SQGIYNNISVSIIE*VLFSH R*G*CTNHGFFEHVIAVILKLTVLV*EFCH*VFK CYSEFSTLVIINVVPH*TCDNLIPVKTD*SAAN NI*YFSSCTN**SSYSRILSVTHYMNKQILSSK ECTRTTIKMSYYFESTKYTKRVCVYSRSYSLPFL *PFNYR**LLEKLI*Y*NFYYESCESMTFVHNS TILNKL*ALRYEVFNRSNQIC*FMAIIKQEQL* NLQSIELLQNHLRIS*AL*NLNFQSLLLNHLECL HLLRCAGSCKILDTNIFIEIRLEKEGRNGFLKY LQKSYCGIYELSS*LC*K*IFTMADMVWIVKF* ALKIFS*PFIIKFNNRFIN*ISLVF*KCFWFVYI YIYKYNIYNK*NT*NSLLCLLVASYSTIYNLIN *KVIILDKNSSQIFTDIISLIFRLLPKCAQWLF VNKEQISFEEGKNFSFLKTACYFNNQVYILKIVS NLK*RSIVSF*ISK*IHIRLKRLCCSLM*PQFL QL*CISLKFYSW*CINYVT*HLELNSSLDI*LV KFLKRLLDLNFFYIFFNMLYVFYLLGHGCHFKI* KY*RTSFLSSKRINKG

Frame 1

RRCRERARTEGSVASVPRACSSGARARRARALP GQTWGPGRVGK*WKRRRWRRPSAERNLRNRPRW GLARAFPRGPFVSGGCCCLAWWAQSSVRRGQAFN RPHIFLLMKL*LLGD*LEKEEKPLGPIQNKYLM LFRLKEKSILFTWKGTKTFCLKILWFILTTRKG L*SLTIPIYRIIVIIGAMWREFIIHPLLLATVLD SEDCCI*RMRVMGLNPCRTALILSTSFIEWMMS TKSL*NVEFPTRI*RKKLQRMKRKSLPA*LSYF EEEELSCHRPGMWSCSLS*TRKGMT*WEEIRLL* EKR*FSWQTTWIVCILC*IFELC*LDWRFGPME T*ST*LGVLVMCWGTSCSGGKSFLSHVGDMTVH S*F*RKVLVELQEWHLWEQCVQGATQAGLMCLDK SLWRHLLPLLLMNWVIILE*ITMMGEIVPVEQR AAS*IQEHRVPETLAVAVQRTLRS*L*IKEETA FLIFQSLMKPIVLPPVVISWWTLGKSVTVVLQRN VNWTLAAKEVPVSLNHLLSVHMVTVVKTVGSFQ EVLYAEEKPVSVMFQSTAMVLLSSVSQMFLFRM DILARITKPIATTACASIMMLNVKSSLAQKPRLP PKIVSLK*ILKVTDLAIVVSLAMNTRSVPLGML CVESFSVRMYKRYLYLELCLLLFKRLVEAPNVG VWISS*DQMFQILGWLTKAQNVVLERSVETSSV* MLLF*IMTVMFRKSVMDMGNEYCIEGRTSGLLL PNCSPYCLCYFYLHQEGSTVEKLLQKEEITNI* VRWQKSSKPF*TAGECSSTCFSSDTSQRSSYICK QICSTNLCSQATSAVPIKATSTTTESIISGKLN SCPSCSCTSFI*FPHLIFLTFFLQMSSGN*ANT FFFS*CFLEKPFCCNYE*KQNTTKQTSLTQKNRN *V*EL*NTRKCSKAREFTITFPFPSLNKSYSVI GEVNALIMDFLNMLLQ*FSN*LYWCKSFVIKCL SVILNFLP*LSLM*FLIEHVII*YL*KLTNQLPI ISNIFHHARINNHHTLESCLSLTT*ISKYCLQK NAQEPQLRCHIILKVQNILKECVCIHAVTRFHF YDLSTIGNNS*RN*FNIRISIMNHVKA*HSFTIA LF*INYKL*GTKYLIDLIKYVDSWL**SRSNYK IFNQLNFYKTT*EFHEHFKI*TFKACY*II*NV YIY*GVLGHVKY*TLIFS*KLGWRKKEEMVFLNT YKKVTVVSMSYHLSCVKNEFLLWQIWYGS*NFK H*KFFHNLS**SLIIGLLTEFH*FFKSVFGLCI YTYTNTTFTINKILEILFCVS**LPTQLFIISLI KKL*F*IKILVKFLQILSH*FSDFCQSVHNGFL LIKNRLVLKKAKISVF*RQHVILTIKYTY*KL* AISNEGPSFHFKSLNEFI*DSNVCAVHSCSLSFC NCDAYH*NFTVGNVLTM*LNTWN*IVLWIFD*L SF*KDYWI*TSFIYFLICFMFFTYLVMDATSKF ENIKGHPFFLQKE*IR

Frame 2

GDVGSELGPRAQLRQCRARARRARVLVGRARFP ARLGAPAGLENDGRGGGGGDRVLRGTCGIGRDG VWRALSLGDPSCPVVAVAWPGGPSPRCGAARLS TDLTSFFL*NYNSLEIN*RKKRSP*ALFKTSILC YSG*RKRAYYSLGKEQRPFA*RFCGLYLQQGRD FNH*PSQYTESLSLSGLCGGSS*FIHCS*RLFW TQRIAAFRECELWD*TPAEQLSF*AHHLSNG*CL QRASEMWSFQQGYRERNCKG*RGRASQHDSATS KKKSCLATDPVCGAVHCRRQGKV*HDGKKSDCC ERRDDSPGKLLG*YVYYVKYSNCASWTGDLDQWK PDQHSWGCW*CAGELRAVAGKVSYHTSET*QCT ASSKERFWWNCRNGICGNSVFKEPRRRD*CVWT NHCGDICFHCCS*IGS*SWNESR*WERLFLWSKE LHHEFRSIGFQKL*QLQCRGL*EVNFK*RRKLP S*YSKA**SL*CSLLW**VGGRWGRV*LWYSKG M*IGPLLRRKYL*A*IIC*VCIW*LL*RLSVPSR RYFMPRKNQ*V*CSRVLQWFFSVLSARCFYSEW ISLPE*QSLLLQRHVPVL*CSMSSHLWLKSQGC PQRLFH*SEF*R*QIWQLWFLWQ*IQEVCHWECF VWKASV*ECTRDTCIWNCACYYSNA*SRHQMLG CGFPARIRCSRSWDG*RRHKMWCWKDL*KLPVC RCFCSEL*L*CSEKVSWTWEMNTALRDGLLVFFF LIVPLIVCAIFIFIKRDQLWRSYFRKKRSQTYE SDGKNQANPSRQPGSVPRHVSPVTPPREVPIYA NRFAVPTYAAKQPQQFPSRPPPPQPKVSSQGNLI PARPAPAPPLYSSLT*FF*PSFCKCLQGTELIL FFFLDVFLKSLSVATMNENKTPQNRLH*HRKTE TECESCEIQGNAVKPGNLQ*HFRFHH*ISLIQSS VRLMH*SWIF*TCYCSDSQINCIGVRVLSLSV* VLF*IFYLSYH*CSSSLNM**SNTCEN*LISCQ *YLIFFIMHELIIIIL*NLVCHSLHE*ANIVFKR MHKNHN*DVILF*KYKIY*KSVCVFTQLLASIF MTFQL*VITLREINLILEFLL*IM*KHDIRSQ* HYFK*IISFKVRSI**I*SNMLIHGYNKAGAIIK SSIN*TFTKPLENFMSTLKSELSKLAIKSFRMF TFTKVCWVM*NIRH*YFHRN*AGERRKKWFS*I PTKKLLWYL*VIILAVLKMNFYYGRYGMDRKILS TKNFFITFHNKV***VY*LNFISFLKVFLVCVY IHIQIQHLQ*IKYLKFSFVSPSSFLLNYL*SH* LKSYNFR*KF*SNFYRYYLTNFQTFAKVCTMAFC **RTD*F*RRQKFQFSEDSMLF*QSSIHIKNCE QSQMKVHRFILNL*MNSYKTQTFVLFTHVASVF AIVMHITEILQLVMY*LCNLTLGIK*FFGYLTS* VFKKTIGSELLLYIF*YALCFLLTWSWMPLQNL KILKDILSFFKKNK*G

Sequence ADAM9.aAug05

TAGGCGATGTCGGGAGCGAGCTCGGACCGAGGGCTCAGTTGCGTCAGTGCCGCGCGCGTGCTCGTCGGGCGCGCGTGCTCGTCGGGCGCGCGCGCTTCCC GGCCAGACTTGGGGCCCCGGCAGGGTTGGAAAATGATGGAAGAGGCGGAGGTGGAGGCGACCGAGTGCTGAGAGGAACCTGCGGAATCGGCCGAGATGGG GTCTGGCGCGCGCTTTCCCTCGGGGACCCTTCGTGTCCGGTGGTTGCTGTTGCTTGGCCTGGTGGGCCCAGTCCTCGGTGCGGCGCGGCCAGGCTTTCAA CAGACCTCACATCTTTCTTCTTATGAAATTATAACTCCTTGGAGATTAACTAGAGAAAGAAGAGAAGCCCCTAGGCCCTATTCAAAACAAGTATCTTATG TTATTCAGGCTGAAGGAAAAGAGCATATTATTCACTTGGAAAGGAACAAAGACCTTTTGCCTGAAGATTTTGTGGTTTATACTTACAACAAGGAAGGGAC TTTAATCACTGACCATCCCAATATACAGAATCATTGTCATTATCGGGGCTATGTGGAGGGAGTTCATAATTCATCCATTGCTCTTAGCGACTGTTTTGGA CTCAGAGGATTGCTGCATTTAGAGAATGCGAGTTATGGGATTGAACCCCTGCAGAACAGCTCTCATTTTGAGCACATCATTTATCGAATGGATGATGTCT ACAAAGAGCCTCTGAAATGTGGAGTTTCCAACAAGGATATAGAGAAAGAAACTGCAAAGGATGAAGAGGAAGAGCCTCCCAGCATGACTCAGCTACTTCG AAGAAGAAGAGCTGTCTTGCCACAGACCCGGTATGTGGAGCTGTTCATTGTCGTAGACAAGGAAAGGTATGACATGATGGGAAGAAATCAGACTGCTGTG AGAGAAGAGATGATTCTCCTGGCAAACTACTTGGATAGTATGTATATTATGTTAAATATTCGAATTGTGCTAGTTGGACTGGAGATTTGGACCAATGGAA ACCTGATCAACATAGTTGGGGGTGCTGGTGATGTGCTGGGGAACTTCGTGCAGTGGCGGGAAAAGTTTCTTATCACACGTCGGAGACATGACAGTGCACA GCTAGTTCTAAAGAAAGGTTTTGGTGGAACTGCAGGAATGGCATTTGTGGGAACAGTGTGTTCAAGGAGCCACGCAGGCGGGATTAATGTGTTTGGACAA ATCACTGTGGAGACATTTGCTTCCATTGTTGCTCATGAATTGGGTCATAATCTTGGAATGAATCACGATGATGGGAGAGATTGTTCCTGTGGAGCAAAGA GCTGCATCATGAATTCAGGAGCATCGGGTTCCAGAAACTTTAGCAGTTGCAGTGCAGAGGACTTTGAGAAGTTAACTTTAAATAAAGGAGGAAACTGCCT TCTTAATATTCCAAAGCCTGATGAAGCCTATAGTGCTCCCTCCTGTGGTAATAAGTTGGTGGACGCTGGGGAAGAGTGTGACTGTGGTACTCCAAAGGAA TGTGAATTGGACCCTTGCTGCGAAGGAAGTACCTGTAAGCTTAAATCATTTGCTGAGTGTGCATATGGTGACTGTTGTAAAGACTGTCGGTTCCTTCCAG GAGGTACTTTATGCCGAGGAAAAACCAGTGAGTGTGATGTTCCAGAGTACTGCAATGGTTCTTCTCAGTTCTGTCAGCCAGATGTTTTTATTCAGAATGG ATATCCTTGCCAGAATAACAAAGCCTATTGCTACAACGGCATGTGCCAGTATTATGATGCTCAATGTCAAGTCATCTTTGGCTCAAAAGCCAAGGCTGCC CCCAAAGATTGTTTCATTGAAGTGAATTCTAAAGGTGACAGATTTGGCAATTGTGGTTTCTCTGGCAATGAATACAAGAAGTGTGCCACTGGGAATGCTT TGTGTGGAAAGCTTCAGTGTGAGAATGTACAAGAGATACCTGTATTTGGAATTGTGCCTGCTATTATTCAAACGCCTAGTCGAGGCACCAAATGTTGGGG TGTGGATTTCCAGCTAGGATCAGATGTTCCAGATCCTGGGATGGTTAACGAAGGCACAAAATGTGGTGCTGGAAAGATCTGTAGAAACTTCCAGTGTGTA GATGCTTCTGTTCTGAATTATGACTGTGATGTTCAGAAAAAGTGTCATGGACATGGGGTATGTAATAGCAATAAGAATTGTCACTGTGAAAATGGCTGGG CTCCCCCAAATTGTGAGACTAAAGGATACGGAGGAAGTGTGGACAGTGGACCTACATACAATGAAATGAATACTGCATTGAGGGACGGACTTCTGGTCTT CTTCTTCCTAATTGTTCCCCTTATTGTCTGTGCTATTTTTATCTTCATCAAGAGGGATCAACTGTGGAGAAGCTACTTCAGAAAGAAGAGATCACAAACA TATGAGTCAGATGGCAAAAATCAAGCAAACCCTTCTAGACAGCCGGGGAGTGTTCCTCGACATGTTTCTCCAGTGACACCTCCCAGAGAAGTTCCTATAT ATGCAAACAGATTTGCAGTACCAACCTATGCAGCCAAGCAACCTCAGCAGTTCCCATCAAGGCCACCTCCACCACAACCGAAAGTATCATCTCAGGGAAA CTTAATTCCTGCCCGTCCTGCTCCTGCACCTCCTTTATATAGTTCCCTCACTTGATTTTTTTAACCTTCTTTTTGCAAATGTCTTCAGGGAACTGAGCTA ATACTTTTTTTTTTTCTTGATGTTTTCTTGAAAAGCCTTTCTGTTGCAACTATGAATGAAAACAAAACACCACAAAACAGACTTCACTAACACAGAAAAA CAGAAACTGAGTGTGAGAGTTGTGAAATACAAGGAAATGCAGTAAAGCCAGGGAATTTACAATAACATTTCCGTTTCCATCATTGAATAAGTCTTATTCA GTCATCGGTGAGGTTAATGCACTAATCATGGATTTTTTGAACATGTTATTGCAGTGATTCTCAAATTAACTGTATTGGTGTAAGAGTTTTGTCATTAAGT GTTTAAGTGTTATTCTGAATTTTCTACCTTAGTTATCATTAATGTAGTTCCTCATTGAACATGTGATAATCTAATACCTGTGAAAACTGACTAATCAGCT GCCAATAATATCTAATATTTTTCATCATGCACGAATTAATAATCATCATACTCTAGAATCTTGTCTGTCACTCACTACATGAATAAGCAAATATTGTCTT CAAAAGAATGCACAAGAACCACAATTAAGATGTCATATTATTTTGAAAGTACAAAATATACTAAAAGAGTGTGTGTGTATTCACGCAGTTACTCGCTTCC ATTTTTATGACCTTTCAACTATAGGTAATAACTCTTAGAGAAATTAATTTAATATTAGAATTTCTATTATGAATCATGTGAAAGCATGACATTCGTTCAC AATAGCACTATTTTAAATAAATTATAAGCTTTAAGGTACGAAGTATTTAATAGATCTAATCAAATATGTTGATTCATGGCTATAATAAAGCAGGAGCAAT TATAAAATCTTCAATCAATTGAACTTTTACAAAACCACTTGAGAATTTCATGAGCACTTTAAAATCTGAACTTTCAAAGCTTGCTATTAAATCATTTAGA ATGTTTACATTTACTAAGGTGTGCTGGGTCATGTAAAATATTAGACACTAATATTTTCATAGAAATTAGGCTGGAGAAAGAAGGAAGAAATGGTTTTCTT AAATACCTACAAAAAAGTTACTGTGGTATCTATGAGTTATCATCTTAGCTGTGTTAAAAATGAATTTTTACTATGGCAGATATGGTATGGATCGTAAAAT TTTAAGCACTAAAAATTTTTTCATAACCTTTCATAATAAAGTTTAATAATAGGTTTATTAACTGAATTTCATTAGTTTTTTAAAAGTGTTTTTGGTTTGT GTATATATACATATACAAATACAACATTTACAATAAATAAAATACTTGAAATTCTCTTTTGTGTCTCCTAGTAGCTTCCTACTCAACTATTTATAATCTC ATTAATTAAAAAGTTATAATTTTAGATAAAAATTCTAGTCAAATTTTTACAGATATTATCTCACTAATTTTCAGACTTTTGCCAAAGTGTGCACAATGGC TTTTTGTTAATAAAGAACAGATTAGTTTTGAAGAAGGCAAAAATTTCAGTTTTCTGAAGACAGCATGTTATTTTAACAATCAAGTATACATATTAAAAAT TGTGAGCAATCTCAAATGAAGGTCCATCGTTTCATTTTAAATCTCTAAATGAATTCATATAAGACTCAAACGTTTGTGCTGTTCACTCATGTAGCCTCAG TTTTTGCAATTGTGATGCATATCACTGAAATTTTACAGTTGGTAATGTATTAACTATGTAACTTAACACTTGGAATTAAATAGTTCTTTGGATATTTGAC TAGTTAAGTTTTTAAAAAGACTATTGGATCTGAACTTCTTTTATATATTTTTTAATATGCTTTATGTTTTTTACTTACTTGGTCATGGATGCCACTTCAA AATTTGAAAATATTAAAGGACATCCTTTCTTTCTTCAAAAAGAATAAATAAGGGT

ADAM9.F3 (forward primer)
ADAM9.R3 (reverse primer)
Single exon skipping

Frame 0

*AMSGASSDRGLSCVSAARVLVGRACSSGARAS RPDLGPRQGWKMMEEAEVEATEC*EEPAESAEMG SGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQ QTSHLSSYEIITPWRLTRERREAPRPYSKQVSY VIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGT LITDHPNIQNHCHYRGYVEGVHNSSIALSDCFG LRGLLHLENASYGIEPLQNSSHFEHIIYRMDDV YKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLR RRRAVLPQTRYVELFIVVDKERYDMMGRNQTAV REEMILLANYLDSMYIMLNIRIVLVGLEIWTNG NLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQ LVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQ ITVETFASIVAHELGHNLGMNHDDGRDCSCGAK SCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCL LNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKE CELDPCCEGSTCKLKSFAECAYGDCCKDCRFLP GGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNG YPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAA PKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNA LCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWG VDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCV DASVLNYDCDVQKKCHGHGVCNSNKNCHCENGW APPNCETKGYGGSVDSGPTYNEMNTALRDGLLVF FFLIVPLIVCAIFIFIKRDQLWRSYFRKKRSQT YESDGKNQANPSRQPGSVPRHVSPVTPPREVPI YANRFAVPTYAAKQPQQFPSRPPPPQPKVSSQGN LIPARPAPAPPLYSSLT*FF*PSFCKCLQGTEL ILFFFLDVFLKSLSVATMNENKTPQNRLH*HRK TETECESCEIQGNAVKPGNLQ*HFRFHH*ISLIQ SSVRLMH*SWIF*TCYCSDSQINCIGVRVLSLS V*VLF*IFYLSYH*CSSSLNM**SNTCEN*LIS CQ*YLIFFIMHELIIIIL*NLVCHSLHE*ANIVF KRMHKNHN*DVILF*KYKIY*KSVCVFTQLLAS IFMTFQL*VITLREINLILEFLL*IM*KHDIRS Q*HYFK*IISFKVRSI**I*SNMLIHGYNKAGAI IKSSIN*TFTKPLENFMSTLKSELSKLAIKSFR MFTFTKVCWVM*NIRH*YFHRN*AGERRKKWFS *IPTKKLLWYL*VIILAVLKMNFYYGRYGMDRKI LSTKNFFITFHNKV***VY*LNFISFLKVFLVC VYIHIQIQHLQ*IKYLKFSFVSPSSFLLNYL*S H*LKSYNFR*KF*SNFYRYYLTNFQTFAKVCTMA FC**RTD*F*RRQKFQFSEDSMLF*QSSIHIKN CEQSQMKVHRFILNL*MNSYKTQTFVLFTHVAS VFAIVMHITEILQLVMY*LCNLTLGIK*FFGYLT S*VFKKTIGSELLLYIF*YALCFLLTWSWMPLQ NLKILKDILSFFKKNK*G

Frame 1

RRCRERARTEGSVASVPRACSSGARARRARALP GQTWGPGRVGK*WKRRRWRRPSAERNLRNRPRW GLARAFPRGPFVSGGCCCLAWWAQSSVRRGQAFN RPHIFLLMKL*LLGD*LEKEEKPLGPIQNKYLM LFRLKEKSILFTWKGTKTFCLKILWFILTTRKG L*SLTIPIYRIIVIIGAMWREFIIHPLLLATVLD SEDCCI*RMRVMGLNPCRTALILSTSFIEWMMS TKSL*NVEFPTRI*RKKLQRMKRKSLPA*LSYF EEEELSCHRPGMWSCSLS*TRKGMT*WEEIRLL* EKR*FSWQTTWIVCILC*IFELC*LDWRFGPME T*ST*LGVLVMCWGTSCSGGKSFLSHVGDMTVH S*F*RKVLVELQEWHLWEQCVQGATQAGLMCLDK SLWRHLLPLLLMNWVIILE*ITMMGEIVPVEQR AAS*IQEHRVPETLAVAVQRTLRS*L*IKEETA FLIFQSLMKPIVLPPVVISWWTLGKSVTVVLQRN VNWTLAAKEVPVSLNHLLSVHMVTVVKTVGSFQ EVLYAEEKPVSVMFQSTAMVLLSSVSQMFLFRM DILARITKPIATTACASIMMLNVKSSLAQKPRLP PKIVSLK*ILKVTDLAIVVSLAMNTRSVPLGML CVESFSVRMYKRYLYLELCLLLFKRLVEAPNVG VWISS*DQMFQILGWLTKAQNVVLERSVETSSV* MLLF*IMTVMFRKSVMDMGYVIAIRIVTVKMAG LPQIVRLKDTEEVWTVDLHTMK*ILH*GTDFWS SSS*LFPLLSVLFLSSSRGINCGEATSERRDHKH MSQMAKIKQTLLDSRGVFLDMFLQ*HLPEKFLY MQTDLQYQPMQPSNLSSSHQGHLHHNRKYHLRE T*FLPVLLLHLLYIVPSLDFFNLLFANVFRELS* YFFFFLMFS*KAFLLQL*MKTKHHKTDFTNTEK QKLSVRVVKYKEMQ*SQGIYNNISVSIIE*VLF SHR*G*CTNHGFFEHVIAVILKLTVLV*EFCH*V FKCYSEFSTLVIINVVPH*TCDNLIPVKTD*SA ANNI*YFSSCTN**SSYSRILSVTHYMNKQILS SKECTRTTIKMSYYFESTKYTKRVCVYSRSYSLP FL*PFNYR**LLEKLI*Y*NFYYESCESMTFVH NSTILNKL*ALRYEVFNRSNQIC*FMAIIKQEQ L*NLQSIELLQNHLRIS*AL*NLNFQSLLLNHLE CLHLLRCAGSCKILDTNIFIEIRLEKEGRNGFL KYLQKSYCGIYELSS*LC*K*IFTMADMVWIVK F*ALKIFS*PFIIKFNNRFIN*ISLVF*KCFWFV YIYIYKYNIYNK*NT*NSLLCLLVASYSTIYNL IN*KVIILDKNSSQIFTDIISLIFRLLPKCAQW LFVNKEQISFEEGKNFSFLKTACYFNNQVYILKI VSNLK*RSIVSF*ISK*IHIRLKRLCCSLM*PQ FLQL*CISLKFYSW*CINYVT*HLELNSSLDI* LVKFLKRLLDLNFFYIFFNMLYVFYLLGHGCHFK I*KY*RTSFLSSKRINKG

Frame 2

GDVGSELGPRAQLRQCRARARRARVLVGRARFP ARLGAPAGLENDGRGGGGGDRVLRGTCGIGRDG VWRALSLGDPSCPVVAVAWPGGPSPRCGAARLS TDLTSFFL*NYNSLEIN*RKKRSP*ALFKTSILC YSG*RKRAYYSLGKEQRPFA*RFCGLYLQQGRD FNH*PSQYTESLSLSGLCGGSS*FIHCS*RLFW TQRIAAFRECELWD*TPAEQLSF*AHHLSNG*CL QRASEMWSFQQGYRERNCKG*RGRASQHDSATS KKKSCLATDPVCGAVHCRRQGKV*HDGKKSDCC ERRDDSPGKLLG*YVYYVKYSNCASWTGDLDQWK PDQHSWGCW*CAGELRAVAGKVSYHTSET*QCT ASSKERFWWNCRNGICGNSVFKEPRRRD*CVWT NHCGDICFHCCS*IGS*SWNESR*WERLFLWSKE LHHEFRSIGFQKL*QLQCRGL*EVNFK*RRKLP S*YSKA**SL*CSLLW**VGGRWGRV*LWYSKG M*IGPLLRRKYL*A*IIC*VCIW*LL*RLSVPSR RYFMPRKNQ*V*CSRVLQWFFSVLSARCFYSEW ISLPE*QSLLLQRHVPVL*CSMSSHLWLKSQGC PQRLFH*SEF*R*QIWQLWFLWQ*IQEVCHWECF VWKASV*ECTRDTCIWNCACYYSNA*SRHQMLG CGFPARIRCSRSWDG*RRHKMWCWKDL*KLPVC RCFCSEL*L*CSEKVSWTWGM**Q*ELSL*KWLG SPKL*D*RIRRKCGQWTYIQ*NEYCIEGRTSGL LLPNCSPYCLCYFYLHQEGSTVEKLLQKEEITN I*VRWQKSSKPF*TAGECSSTCFSSDTSQRSSYI CKQICSTNLCSQATSAVPIKATSTTTESIISGK LNSCPSCSCTSFI*FPHLIFLTFFLQMSSGN*A NTFFFS*CFLEKPFCCNYE*KQNTTKQTSLTQKN RN*V*EL*NTRKCSKAREFTITFPFPSLNKSYS VIGEVNALIMDFLNMLLQ*FSN*LYWCKSFVIK CLSVILNFLP*LSLM*FLIEHVII*YL*KLTNQL PIISNIFHHARINNHHTLESCLSLTT*ISKYCL QKNAQEPQLRCHIILKVQNILKECVCIHAVTRF HFYDLSTIGNNS*RN*FNIRISIMNHVKA*HSFT IALF*INYKL*GTKYLIDLIKYVDSWL**SRSN YKIFNQLNFYKTT*EFHEHFKI*TFKACY*II* NVYIY*GVLGHVKY*TLIFS*KLGWRKKEEMVFL NTYKKVTVVSMSYHLSCVKNEFLLWQIWYGS*N FKH*KFFHNLS**SLIIGLLTEFH*FFKSVFGL CIYTYTNTTFTINKILEILFCVS**LPTQLFIIS LIKKL*F*IKILVKFLQILSH*FSDFCQSVHNG FLLIKNRLVLKKAKISVF*RQHVILTIKYTY*K L*AISNEGPSFHFKSLNEFI*DSNVCAVHSCSLS FCNCDAYH*NFTVGNVLTM*LNTWN*IVLWIFD *LSF*KDYWI*TSFIYFLICFMFFTYLVMDATS KFENIKGHPFFLQKE*IR