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Sequences

Sequence CHEK2.jAug05

GCCTTCTCTTCCGCCAGCCAGATCCGTCCTCCCCTCTCGCAGGCCAGACCTCGACGTGTCTCTCGCCCGGGCCCGTTTCCCGAAACCGTCGCTCGTACCA GTCCATAAGGCTGAAGTAGTCTCGAGTGGGGTCAGGTGCCTGCAGCGCTCGGCACTGTGGGCAGAAGAACCTGTCCTCCCGCCCGGGGCCCCATGGGCCG CCGCAGTTCCAACAGCGGGGATAATTGCTTCCCGCCTGCGACGCAGCATCGCAGCTTAGCGGTCTCCTTCTGGGAACCCCTGTCGGCCAAAACCCCCACA CCCGGAGCAAAGCCCCGGCTCTCCCCCGCCACATCTGGCCGGCGGCCTATCTAGCCGTGGTCACTCGTGGGGAAAAGCAAAGAGAGCGTCTAACCAGACT AATGTTGCTGATTGGCTGGGGAGTCGAGGGGGCGGGATCACCCGAGGGGAACCCGGGTTCTAAGTTCCGCTCTCCCTTCTAAACTACAACTCCCAGGAGG CATTGAGGCGGCGCCTGACGGCCACATCTGCTGCTCCTCATTGGTCCGGCGGCAGGGGAGGGGGTTTTGATTGGCTGAGGGTGGAGTTTGTATCTGCAGG TTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTGTGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAG TCTCATGGCAGCAGTGCCTGTTCACAGCCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCA CGATGCCAAACTCCAGCCAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCA AGAACCTGAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGAATGTGTGAATGAC AACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAAGAACAGATAAATACCGAACATACAGCAAGAAACACTTTC GGATTTTCAGGGAAGTGGGTCCTAAAAACTCTTACATTGCATACATAGAAGATCACAGTGGCAATGGAACCTTTGTAAATACAGAGCTTGTAGGGAAAGG AAAACGCCGTCCTTTGAATAACAATTCTGAAATTGCACTGTCACTAAGCAGAAATAAAGAGAAAATACTTAAAATCTACTCTCTCAGCTGATTTTCAAAA ATACGGCGGGGCGCGGTGGCTCACGTCTTTAATCCCAGCACTTTGGGAGGCCGAGGCTGGCAGATCACCTGAGTTTTTGTCTTTTTTGATCTGACTGTAG ATGATCAGTCAGTTTATCCTAAGGCATTAAGAGATGAATACATCATGTCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAAGCTGGCTTTCGAGAG GAAAACATGTAAGAAAGTAGCCATAAAGATCATCAGCAAAAGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTCAATGTTGAAACAGAA ATAGAAATTTTGAAAAAGCTAAATCATCCTTGCATCATCAAGATTAAAAACTTTTTTGATGCAGAAGATTATTATATTGTTTTGGAATTGATGGAAGGGG GAGAGCTGTTTGACAAAGTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTGGCTGTGCAGTACCTTCATGA AAACGGTATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGATTTTGGGCACTCCAAG ATTTTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTGCTGGGTATAACCGTG CTGTGGACTGCTGGAGTTTAGGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACTCAAGTGTCACTGAAGGATCAGAT CACCAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCAGAAGTCTCAGAGAAAGCTCTGGACCTTGTCAAGAAGTTGTTGGTAGTGGATCCAAAGGCA CGTTTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAGAGAAAGTTTCAAGATCTTCTGTCTGAGGAAAATGAATCCACAG CTCTACCCCAGGTTCTAGCCCAGCCTTCTACTAGTCGAAAGCGGCCCCGTGAAGGGGAAGCCGAGGGTGCCGAGACCACAAAGCGCCCAGCTGTGTGTGC TGCTGTGTTGTGAACTCCGTGGTTTGAACACGAAAGAAATGTACCTTCTTTCACTCTGTCATCTTTCTTTTCTTTGAGTCTGTTTTTTTATAGTTTGTAT TTTAATTATGGGAATAATTGCTTTTTCACAGTCACTGATGTACAATTAAAAACCTGATGGAACCTGGGCTTTGTGCTTCTGCTTGATAATCGGTTCTTTA GTTGAATGGCTTTATTATTTATTTATTTGAGATGGAGTCTCACTCTGTTGCCCAGCCTGAATGAAGTGCAGTGGTGCAGGCTTGGCTCACTGCAACCTCT GCTTCCCAGGTTCAAGCGATTCTTGTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTATGCACCACCATGCCTGTTAATTTTTATATATTTTG

CHEK2.u.f.13 (forward primer)
CHEK2.u.r.25 (reverse primer)
Mutually exclusive exon skipping

Frame 0

AFSSASQIRPPLSQARPRRVSRPGPFPETVART SP*G*SSLEWGQVPAALGTVGRRTCPPARGPMGR RSSNSGDNCFPPATQHRSLAVSFWEPLSAKTPT PGAKPRLSPATSGRRPI*PWSLVGKSKESV*PD *CC*LAGESRGRDHPRGTRVLSSALPSKLQLPGG IEAAPDGHICCSSLVRRQGRGF*LAEGGVCICR FSATLLAEAAESVRLQVGSRGRDVSGVGC*GSA VSWQQCLFTAPWQRYPVPRLLLTVPGHIQLLYQH DAKLQPVLSLQLWDTELLRDSVHSGTLFYS*GP RT*GPRT*GAYPCPLGSIMGPSGWICQS*MCE* QLLVWEGQKL*ILL**TTAEKNR*IPNIQQETLS DFQGSGS*KLLHCIHRRSQWQWNLCKYRACRER KTPSFE*QF*NCTVTKQK*RENT*NLLSQLIFK NTAGRGGSRL*SQHFGRPRLADHLSFCLF*SDCR *SVSLS*GIKR*IHHVKNSWKWCLWRGKAGFRE ENM*ESSHKDHQQKEVCYWFSKRGRPSSQC*NR NRNFEKAKSSLHHQD*KLF*CRRLLYCFGIDGRG RAV*QSGGE*TPERSYLQALFLPDALGCAVPS* KRYYTP*LKARECFTVISRRGLSYKDY*FWALQ DFGRDLSHENLMWNPHLLGA*SSCFCWDCWV*PC CGLLEFRSYSFYLP*WVSTFL*A*DSSVTEGSD HQWKIQLHS*SLGRSLRESSGPCQEVVGSGSKG TFYDRRSLKTPVASG*RHEEKVSRSSV*GK*IHS STPGSSPAFY*SKAAP*RGSRGCRDHKAPSCVC CCVVNSVV*TRKKCTFFHSVIFLFFESVFL*FV F*LWE*LLFHSH*CTIKNLMEPGLCASA**SVL* LNGFIIYLFEMESHSVAQPE*SAVVQAWLTATS ASQVQAILVPQPPE*LGLQVCTTMPVNFYIF

Frame 1

PSLPPARSVLPSRRPDLDVSLARARFPKPSLVP VHKAEVVSSGVRCLQRSALWAEEPVLPPGAPWA AAVPTAGIIASRLRRSIAA*RSPSGNPCRPKPPH PEQSPGSPPPHLAGGLSSRGHSWGKAKRASNQT NVADWLGSRGGGITRGEPGF*VPLSLLNYNSQE ALRRRLTATSAAPHWSGGRGGGFDWLRVEFVSAG LAPLCWLRLRRVCGSRWAHAVVMSRESDVEAQQ SHGSSACSQPHGSVTQSQGSSSQSQGISSSSTS TMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQ EPEDQEPEEPTPAPWARLWALQDGFANLECVND NYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHF RIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKG KRRPLNNNSEIALSLSRNKEKILKIYSLS*FSK IRRGAVAHVFNPSTLGGRGWQIT*VFVFFDLTV DDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER KTCKKVAIKIISKRKFAIGSAREADPALNVETE IEILKKLNHPCIIKIKNFFDAEDYYIVLELMEG GELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHE NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSK ILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNR AVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQI TSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKA RFTTEEALRHPWLQDEDMKRKFQDLLSEENEST ALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA AVL*TPWFEHERNVPSFTLSSFFSLSLFFYSLY FNYGNNCFFTVTDVQLKT*WNLGFVLLLDNRFF S*MALLFIYLRWSLTLLPSLNEVQWCRLGSLQPL LPRFKRFLCLSLLSSWDYRYAPPCLLIFIYF

Frame 2

LLFRQPDPSSPLAGQTSTCLSPGPVSRNRRSYQ SIRLK*SRVGSGACSARHCGQKNLSSRPGPHGP PQFQQRG*LLPACDAASQLSGLLLGTPVGQNPH TRSKAPALPRHIWPAAYLAVVTRGEKQRERLTRL MLLIGWGVEGAGSPEGNPGSKFRSPF*TTTPRR H*GGA*RPHLLLLIGPAAGEGVLIG*GWSLYLQ V*RHSAG*GCGECAAPGGLTRS*CLGSRMLRLSS LMAAVPVHSPMAALPSPKAPPHSPRAYPAPLPA RCQTPASPLTPALGH*AP*RQCPLRNSILFLRT KNLRTKNLRSLPLPPGLDYGPFRMDLPILNV*MT TTGLGGTKAVNIALMNHC*KEQINTEHTARNTF GFSGKWVLKTLTLHT*KITVAMEPL*IQSL*GK ENAVL*ITILKLHCH*AEIKRKYLKSTLSADFQK YGGARWLTSLIPALWEAEAGRSPEFLSFLI*L* MISQFILRH*EMNTSCQKLLEVVPVER*SWLSR GKHVRK*P*RSSAKGSLLLVQQERQTQLSMLKQK *KF*KS*IILASSRLKTFLMQKIIILFWN*WKG ESCLTKWWGINA*KKLPASSIFTRCSWLCSTFM KTVLYTVT*SQRMFYCHLKKRTVL*RLLILGTPR FWERPLS*EPYVEPPPTWRLKFLFLLGLLGITV LWTAGV*ELFFLSALVGIHLSLSIGLKCH*RIR SPVENTTSFLKSGQKSQRKLWTLSRSCW*WIQRH VLRQKKP*DTRGFRMKT*RESFKIFCLRKMNPQ LYPRF*PSLLLVESGPVKGKPRVPRPQSAQLCV LLCCELRGLNTKEMYLLSLCHLSFL*VCFFIVCI LIMGIIAFSQSLMYN*KPDGTWALCFCLIIGSL VEWLYYLFI*DGVSLCCPA*MKCSGAGLAHCNL CFPGSSDSCASAS*VAGITGMHHHAC*FLYIL

Sequence CHEK2.hAug05

GCCTTCTCTTCCGCCAGCCAGATCCGTCCTCCCCTCTCGCAGGCCAGACCTCGACGTGTCTCTCGCCCGGGCCCGTTTCCCGAAACCGTCGCTCGTACCA GTCCATAAGGCTGAAGTAGTCTCGAGTGGGGTCAGGTGCCTGCAGCGCTCGGCACTGTGGGCAGAAGAACCTGTCCTCCCGCCCGGGGCCCCATGGGCCG CCGCAGTTCCAACAGCGGGGATAATTGCTTCCCGCCTGCGACGCAGCATCGCAGCTTAGCGGTCTCCTTCTGGGAACCCCTGTCGGCCAAAACCCCCACA CCCGGAGCAAAGCCCCGGCTCTCCCCCGCCACATCTGGCCGGCGGCCTATCTAGCCGTGGTCACTCGTGGGGAAAAGCAAAGAGAGCGTCTAACCAGACT AATGTTGCTGATTGGCTGGGGAGTCGAGGGGGCGGGATCACCCGAGGGGAACCCGGGTTCTAAGTTCCGCTCTCCCTTCTAAACTACAACTCCCAGGAGG CATTGAGGCGGCGCCTGACGGCCACATCTGCTGCTCCTCATTGGTCCGGCGGCAGGGGAGGGGGTTTTGATTGGCTGAGGGTGGAGTTTGTATCTGCAGG TTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTGTGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAG TCTCATGGCAGCAGTGCCTGTTCACAGCCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCA CGATGCCAAACTCCAGCCAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCA AGAACCTGAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGAATGTGTGAATGAC AACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAAGAACAGATAAATACCGAACATACAGCAAGAAACACTTTC GGATTTTCAGGGAGGAAAATTTGTCCTGTCCTTACAGAATATGGTTTAAGTGAGTAAAGATGAGTAAGTTGCTGGGCGTGGTGGCTCACACCTGTAATCC CAGCACTTTGGGAGGCTGAGGCGGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCCACATGGAGAAACCCTGTCTCTACTAAAAATACAAA ATAAGCCGGGCATGGTGGTGCATGCCTGTAATCCCAGCTATTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCA AGATCGTGCCATTGCACTCTAGCCTGGGCAACAAGAGTGAAACTCTGTCTCAAAACAAAAAAAAAGATGATTTTTGTCTTTTTTGATCTGACTGTAGATG ATCAGTCAGTTTATCCTAAGGCATTAAGAGATGAATACATCATGTCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAAGCTGGCTTTCGAGAGGAA AACATGTAAGAAAGTAGCCATAAAGATCATCAGCAAAAGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTCAATGTTGAAACAGAAATA GAAATTTTGAAAAAGCTAAATCATCCTTGCATCATCAAGATTAAAAACTTTTTTGATGCAGAAGATTATTATATTGTTTTGGAATTGATGGAAGGGGGAG AGCTGTTTGACAAAGTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTGGCTGTGCAGTACCTTCATGAAAA CGGTATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGATTTTGGGCACTCCAAGATT TTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTGCTGGGTATAACCGTGCTG TGGACTGCTGGAGTTTAGGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACTCAAGTGTCACTGAAGGATCAGATCAC CAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCAGAAGTCTCAGAGAAAGCTCTGGACCTTGTCAAGAAGTTGTTGGTAGTGGATCCAAAGGCACGT TTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAGAGAAAGTTTCAAGATCTTCTGTCTGAGGAAAATGAATCCACAGCTC TACCCCAGGTTCTAGCCCAGCCTTCTACTAGTCGAAAGCGGCCCCGTGAAGGGGAAGCCGAGGGTGCCGAGACCACAAAGCGCCCAGCTGTGTGTGCTGC TGTGTTGTGAACTCCGTGGTTTGAACACGAAAGAAATGTACCTTCTTTCACTCTGTCATCTTTCTTTTCTTTGAGTCTGTTTTTTTATAGTTTGTATTTT AATTATGGGAATAATTGCTTTTTCACAGTCACTGATGTACAATTAAAAACCTGATGGAACCTGGGCTTTGTGCTTCTGCTTGATAATCGGTTCTTTAGTT GAATGGCTTTATTATTTATTTATTTGAGATGGAGTCTCACTCTGTTGCCCAGCCTGAATGAAGTGCAGTGGTGCAGGCTTGGCTCACTGCAACCTCTGCT TCCCAGGTTCAAGCGATTCTTGTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTATGCACCACCATGCCTGTTAATTTTTATATATTTTG

CHEK2.u.f.13 (forward primer)
CHEK2.u.r.25 (reverse primer)
Mutually exclusive exon skipping

Frame 0

AFSSASQIRPPLSQARPRRVSRPGPFPETVART SP*G*SSLEWGQVPAALGTVGRRTCPPARGPMGR RSSNSGDNCFPPATQHRSLAVSFWEPLSAKTPT PGAKPRLSPATSGRRPI*PWSLVGKSKESV*PD *CC*LAGESRGRDHPRGTRVLSSALPSKLQLPGG IEAAPDGHICCSSLVRRQGRGF*LAEGGVCICR FSATLLAEAAESVRLQVGSRGRDVSGVGC*GSA VSWQQCLFTAPWQRYPVPRLLLTVPGHIQLLYQH DAKLQPVLSLQLWDTELLRDSVHSGTLFYS*GP RT*GPRT*GAYPCPLGSIMGPSGWICQS*MCE* QLLVWEGQKL*ILL**TTAEKNR*IPNIQQETLS DFQGGKFVLSLQNMV*VSKDE*VAGRGGSHL*S QHFGRLRRMDHLRSGVRDQPDPHGETLSLLKIQ NKPGMVVHACNPSYSGG*GRRIA*TREAEVAVSQ DRAIAL*PGQQE*NSVSKQKKR*FLSFLI*L*M ISQFILRH*EMNTSCQKLLEVVPVER*SWLSRG KHVRK*P*RSSAKGSLLLVQQERQTQLSMLKQK* KF*KS*IILASSRLKTFLMQKIIILFWN*WKGE SCLTKWWGINA*KKLPASSIFTRCSWLCSTFMK TVLYTVT*SQRMFYCHLKKRTVL*RLLILGTPRF WERPLS*EPYVEPPPTWRLKFLFLLGLLGITVL WTAGV*ELFFLSALVGIHLSLSIGLKCH*RIRS PVENTTSFLKSGQKSQRKLWTLSRSCW*WIQRHV LRQKKP*DTRGFRMKT*RESFKIFCLRKMNPQL YPRF*PSLLLVESGPVKGKPRVPRPQSAQLCVL LCCELRGLNTKEMYLLSLCHLSFL*VCFFIVCIL IMGIIAFSQSLMYN*KPDGTWALCFCLIIGSLV EWLYYLFI*DGVSLCCPA*MKCSGAGLAHCNLC FPGSSDSCASAS*VAGITGMHHHAC*FLYIL

Frame 1

PSLPPARSVLPSRRPDLDVSLARARFPKPSLVP VHKAEVVSSGVRCLQRSALWAEEPVLPPGAPWA AAVPTAGIIASRLRRSIAA*RSPSGNPCRPKPPH PEQSPGSPPPHLAGGLSSRGHSWGKAKRASNQT NVADWLGSRGGGITRGEPGF*VPLSLLNYNSQE ALRRRLTATSAAPHWSGGRGGGFDWLRVEFVSAG LAPLCWLRLRRVCGSRWAHAVVMSRESDVEAQQ SHGSSACSQPHGSVTQSQGSSSQSQGISSSSTS TMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQ EPEDQEPEEPTPAPWARLWALQDGFANLECVND NYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHF RIFREENLSCPYRIWFK*VKMSKLLGVVAHTCNP STLGG*GGWIT*GQEFETSLTHMEKPCLY*KYK ISRAWWCMPVIPAIREAEAGESLEPGRQRLQ*A KIVPLHSSLGNKSETLSQNKKKDDFCLF*SDCR* SVSLS*GIKR*IHHVKNSWKWCLWRGKAGFREE NM*ESSHKDHQQKEVCYWFSKRGRPSSQC*NRN RNFEKAKSSLHHQD*KLF*CRRLLYCFGIDGRGR AV*QSGGE*TPERSYLQALFLPDALGCAVPS*K RYYTP*LKARECFTVISRRGLSYKDY*FWALQD FGRDLSHENLMWNPHLLGA*SSCFCWDCWV*PCC GLLEFRSYSFYLP*WVSTFL*A*DSSVTEGSDH QWKIQLHS*SLGRSLRESSGPCQEVVGSGSKGT FYDRRSLKTPVASG*RHEEKVSRSSV*GK*IHSS TPGSSPAFY*SKAAP*RGSRGCRDHKAPSCVCC CVVNSVV*TRKKCTFFHSVIFLFFESVFL*FVF *LWE*LLFHSH*CTIKNLMEPGLCASA**SVL*L NGFIIYLFEMESHSVAQPE*SAVVQAWLTATSA SQVQAILVPQPPE*LGLQVCTTMPVNFYIF

Frame 2

LLFRQPDPSSPLAGQTSTCLSPGPVSRNRRSYQ SIRLK*SRVGSGACSARHCGQKNLSSRPGPHGP PQFQQRG*LLPACDAASQLSGLLLGTPVGQNPH TRSKAPALPRHIWPAAYLAVVTRGEKQRERLTRL MLLIGWGVEGAGSPEGNPGSKFRSPF*TTTPRR H*GGA*RPHLLLLIGPAAGEGVLIG*GWSLYLQ V*RHSAG*GCGECAAPGGLTRS*CLGSRMLRLSS LMAAVPVHSPMAALPSPKAPPHSPRAYPAPLPA RCQTPASPLTPALGH*AP*RQCPLRNSILFLRT KNLRTKNLRSLPLPPGLDYGPFRMDLPILNV*MT TTGLGGTKAVNIALMNHC*KEQINTEHTARNTF GFSGRKICPVLTEYGLSE*R*VSCWAWWLTPVI PALWEAEADGSPEVRSSRPA*PTWRNPVSTKNTK *AGHGGACL*SQLFGRLRQENRLNPGGRGCSEP RSCHCTLAWATRVKLCLKTKKKMIFVFFDLTVD DQSVYPKALRDEYIMSKTLGSGACGEVKLAFERK TCKKVAIKIISKRKFAIGSAREADPALNVETEI EILKKLNHPCIIKIKNFFDAEDYYIVLELMEGG ELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHEN GIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRA VDCWSLGVILFICLSGYPPFSEHRTQVSLKDQIT SGKYNFIPEVWAEVSEKALDLVKKLLVVDPKAR FTTEEALRHPWLQDEDMKRKFQDLLSEENESTA LPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAA VL*TPWFEHERNVPSFTLSSFFSLSLFFYSLYF NYGNNCFFTVTDVQLKT*WNLGFVLLLDNRFFS *MALLFIYLRWSLTLLPSLNEVQWCRLGSLQPLL PRFKRFLCLSLLSSWDYRYAPPCLLIFIYF