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Sequences

Sequence CHEK2.iAug05

GTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAGCCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCT
CCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGCCAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGAC
AGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCTGAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTATGGGCC
CTTCAGGATGGATTTGCCAATCTTGAATGTGTGAATGACAACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAA
GAACAGATAAATACCGAACATACAGCAAGAAACACTTTCGGATTTTCAGGGAGGAAAATTTGTCCTGTCCTTACAGAATATGGTTTAATTTTTGTCTTTT
TTGATCTGACTGTAGATGATCAGTCAGTTTATCCTAAGGCATTAAGAGATGAATACATCATGTCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAA
GCTGGCTTTCGAGAGGAAAACATGTAAGAAAGTAGCCATAAAGATCATCAGCAAAAGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTC
AATGTTGAAACAGAAATAGAAATTTTGAAAAAGCTAAATCATCCTTGCATCATCAAGATTAAAAACTTTTTTGATGCAGAAGATTATTATATTGTTTTGG
AATTGATGGAAGGGGGAGAGCTGTTTGACAAAGTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTGGCTGT
GCAGTACCTTCATGAAAACGGTATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGAT
TTTGGGCACTCCAAGATTTTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTG
CTGGGTATAACCGTGCTGTGGACTGCTGGAGTTTAGGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACTCAAGTGTC
ACTGAAGGATCAGATCACCAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCAGAAGTCTCAGAGAAAGCTCTGGACCTTGTCAAGAAGTTGTTGGTA
GTGGATCCAAAGGCACGTTTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAGAGAAAGTTTCAAGATCTTCTGTCTGAGG
AAAATGAATCCACAGCTCTACCCCAGGTTCTAGCCCAGCCTTCTACTAGTCGAAAGCGGCCCCGTGAAGGGGAAGCCGAGGGTGCCGAGACCACAAAGCG
CCCAGCTGTGTGTGCTGCTGTGTTGTGAACTCCGTGGTTTGAACACGAAAGAAATGTACCTTCTTTCACTCTGTCATCTTTCTTTTCTTTGAGTCTGTTT
TTTTATAGTTTGTATTTTAATTATGGGAATAATTGCTTTTTCACAGTCACTGATGTACAATTAAAAACCTGATGGAACCTGGGCTTTGTGCTTCTGCTTG
ATAATCGGTTCTTTAGTTGAATGGCTTTATTATTTATTTATTTGAGATGGAGTCTCACTCTGTTGCCCAGCCTGAATGAAGTGCAGTGGTGCAGGCTTGG
CTCACTGCAACCTCTGCTTCCCAGGTTCAAGCGATTCTTGTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTATGCACCACCATGCCTGTTAATTTTT
ATATATTTTG
  • CHEK2.u.f.13 (forward primer)
  • CHEK2.u.r.25 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

VVMSRESDVEAQQSHGSSACSQPHGSVTQSQGS
SSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLET
VSTQELYSIPEDQEPEDQEPEEPTPAPWARLWA
LQDGFANLECVNDNYWFGRDKSCEYCFDEPLLK
RTDKYRTYSKKHFRIFREENLSCPYRIWFNFCLF
*SDCR*SVSLS*GIKR*IHHVKNSWKWCLWRGK
AGFREENM*ESSHKDHQQKEVCYWFSKRGRPSS
QC*NRNRNFEKAKSSLHHQD*KLF*CRRLLYCFG
IDGRGRAV*QSGGE*TPERSYLQALFLPDALGC
AVPS*KRYYTP*LKARECFTVISRRGLSYKDY*
FWALQDFGRDLSHENLMWNPHLLGA*SSCFCWDC
WV*PCCGLLEFRSYSFYLP*WVSTFL*A*DSSV
TEGSDHQWKIQLHS*SLGRSLRESSGPCQEVVG
SGSKGTFYDRRSLKTPVASG*RHEEKVSRSSV*G
K*IHSSTPGSSPAFY*SKAAP*RGSRGCRDHKA
PSCVCCCVVNSVV*TRKKCTFFHSVIFLFFESV
FL*FVF*LWE*LLFHSH*CTIKNLMEPGLCASA*
*SVL*LNGFIIYLFEMESHSVAQPE*SAVVQAW
LTATSASQVQAILVPQPPE*LGLQVCTTMPVNF
YIF

Frame 1

S*CLGSRMLRLSSLMAAVPVHSPMAALPSPKAP
PHSPRAYPAPLPARCQTPASPLTPALGH*AP*R
QCPLRNSILFLRTKNLRTKNLRSLPLPPGLDYGP
FRMDLPILNV*MTTTGLGGTKAVNIALMNHC*K
EQINTEHTARNTFGFSGRKICPVLTEYGLIFVF
FDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVK
LAFERKTCKKVAIKIISKRKFAIGSAREADPAL
NVETEIEILKKLNHPCIIKIKNFFDAEDYYIVL
ELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAV
QYLHENGIIHRDLKPENVLLSSQEEDCLIKITD
FGHSKILGETSLMRTLCGTPTYLAPEVLVSVGT
AGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVS
LKDQITSGKYNFIPEVWAEVSEKALDLVKKLLV
VDPKARFTTEEALRHPWLQDEDMKRKFQDLLSE
ENESTALPQVLAQPSTSRKRPREGEAEGAETTKR
PAVCAAVL*TPWFEHERNVPSFTLSSFFSLSLF
FYSLYFNYGNNCFFTVTDVQLKT*WNLGFVLLL
DNRFFS*MALLFIYLRWSLTLLPSLNEVQWCRLG
SLQPLLPRFKRFLCLSLLSSWDYRYAPPCLLIF
IYF

Frame 2

RDVSGVGC*GSAVSWQQCLFTAPWQRYPVPRLL
LTVPGHIQLLYQHDAKLQPVLSLQLWDTELLRD
SVHSGTLFYS*GPRT*GPRT*GAYPCPLGSIMG
PSGWICQS*MCE*QLLVWEGQKL*ILL**TTAEK
NR*IPNIQQETLSDFQGGKFVLSLQNMV*FLSF
LI*L*MISQFILRH*EMNTSCQKLLEVVPVER*
SWLSRGKHVRK*P*RSSAKGSLLLVQQERQTQLS
MLKQK*KF*KS*IILASSRLKTFLMQKIIILFW
N*WKGESCLTKWWGINA*KKLPASSIFTRCSWL
CSTFMKTVLYTVT*SQRMFYCHLKKRTVL*RLLI
LGTPRFWERPLS*EPYVEPPPTWRLKFLFLLGL
LGITVLWTAGV*ELFFLSALVGIHLSLSIGLKC
H*RIRSPVENTTSFLKSGQKSQRKLWTLSRSCW*
WIQRHVLRQKKP*DTRGFRMKT*RESFKIFCLR
KMNPQLYPRF*PSLLLVESGPVKGKPRVPRPQS
AQLCVLLCCELRGLNTKEMYLLSLCHLSFL*VCF
FIVCILIMGIIAFSQSLMYN*KPDGTWALCFCL
IIGSLVEWLYYLFI*DGVSLCCPA*MKCSGAGL
AHCNLCFPGSSDSCASAS*VAGITGMHHHAC*FL
YIL

Sequence CHEK2.jAug05

GCCTTCTCTTCCGCCAGCCAGATCCGTCCTCCCCTCTCGCAGGCCAGACCTCGACGTGTCTCTCGCCCGGGCCCGTTTCCCGAAACCGTCGCTCGTACCA
GTCCATAAGGCTGAAGTAGTCTCGAGTGGGGTCAGGTGCCTGCAGCGCTCGGCACTGTGGGCAGAAGAACCTGTCCTCCCGCCCGGGGCCCCATGGGCCG
CCGCAGTTCCAACAGCGGGGATAATTGCTTCCCGCCTGCGACGCAGCATCGCAGCTTAGCGGTCTCCTTCTGGGAACCCCTGTCGGCCAAAACCCCCACA
CCCGGAGCAAAGCCCCGGCTCTCCCCCGCCACATCTGGCCGGCGGCCTATCTAGCCGTGGTCACTCGTGGGGAAAAGCAAAGAGAGCGTCTAACCAGACT
AATGTTGCTGATTGGCTGGGGAGTCGAGGGGGCGGGATCACCCGAGGGGAACCCGGGTTCTAAGTTCCGCTCTCCCTTCTAAACTACAACTCCCAGGAGG
CATTGAGGCGGCGCCTGACGGCCACATCTGCTGCTCCTCATTGGTCCGGCGGCAGGGGAGGGGGTTTTGATTGGCTGAGGGTGGAGTTTGTATCTGCAGG
TTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTGTGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAG
TCTCATGGCAGCAGTGCCTGTTCACAGCCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCA
CGATGCCAAACTCCAGCCAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCA
AGAACCTGAGGACCA
AGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGAATGTGTGAATGAC
AACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAAGAACAGATAAATACCGAACATACAGCAAGAAACACTTTC
GGATTTTCAGGGAAGTGGGTCCTAAAAACTCTTACATTGCATACATAGAAGATCACAGTGGCAATGGAACCTTTGTAAATACAGAGCTTGTAGGGAAAGG
AAAACGCCGTCCTTTGAATAACAATTCTGAAATTGCACTGTCACTAAGCAGAAATAAAGAGAAAATACTTAAAATCTACTCTCTCAGCTGATTTTCAAAA
ATACGGCGGGGCGCGGTGGCTCACGTCTTTAATCCCAGCACTTTGGGAGGCCGAGGCTGGCAGATCACCTGAG
TTTTTGTCTTTTTTGATCTGACTGTAG
ATGATCAGTCAGTTTATCCTAAGGCATTAAGAGATGAATACATCATGTCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAAGCTGGCTTTCGAGAG
GAAAACATGTAAGAAAGTAGCCATAAAGATCATCAGCAAAAGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTCAATGTTGAAACAGAA
ATAGAAATTTTGAAAAAGCTAAATCATCCTTGCATCATCAAGATTAAAAACTTTTTTGATGCAGAAGATTATTATATTGTTTTGGAATTGATGGAAGGGG
GAGAGCTGTTTGACAAAGTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTGGCTGTGCAGTACCTTCATGA
AAACGGTATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGATTTTGGGCACTCCAAG
ATTTTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTGCTGGGTATAACCGTG
CTGTGGACTGCTGGAGTTTAGGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACTCAAGTGTCACTGAAGGATCAGAT
CACCAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCAGAAGTCTCAGAGAAAGCTCTGGACCTTGTCAAGAAGTTGTTGGTAGTGGATCCAAAGGCA
CGTTTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAGAGAAAGTTTCAAGATCTTCTGTCTGAGGAAAATGAATCCACAG
CTCTACCCCAGGTTCTAGCCCAGCCTTCTACTAGTCGAAAGCGGCCCCGTGAAGGGGAAGCCGAGGGTGCCGAGACCACAAAGCGCCCAGCTGTGTGTGC
TGCTGTGTTGTGAACTCCGTGGTTTGAACACGAAAGAAATGTACCTTCTTTCACTCTGTCATCTTTCTTTTCTTTGAGTCTGTTTTTTTATAGTTTGTAT
TTTAATTATGGGAATAATTGCTTTTTCACAGTCACTGATGTACAATTAAAAACCTGATGGAACCTGGGCTTTGTGCTTCTGCTTGATAATCGGTTCTTTA
GTTGAATGGCTTTATTATTTATTTATTTGAGATGGAGTCTCACTCTGTTGCCCAGCCTGAATGAAGTGCAGTGGTGCAGGCTTGGCTCACTGCAACCTCT
GCTTCCCAGGTTCAAGCGATTCTTGTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTATGCACCACCATGCCTGTTAATTTTTATATATTTTG
  • CHEK2.u.f.13 (forward primer)
  • CHEK2.u.r.25 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

AFSSASQIRPPLSQARPRRVSRPGPFPETVART
SP*G*SSLEWGQVPAALGTVGRRTCPPARGPMGR
RSSNSGDNCFPPATQHRSLAVSFWEPLSAKTPT
PGAKPRLSPATSGRRPI*PWSLVGKSKESV*PD
*CC*LAGESRGRDHPRGTRVLSSALPSKLQLPGG
IEAAPDGHICCSSLVRRQGRGF*LAEGGVCICR
FSATLLAEAAESVRLQVGSRGRDVSGVGC*GSA
VSWQQCLFTAPWQRYPVPRLLLTVPGHIQLLYQH
DAKLQPVLSLQLWDTELLRDSVHSGTLFYS*GP
RT*GP
RT*GAYPCPLGSIMGPSGWICQS*MCE*
QLLVWEGQKL*ILL**TTAEKNR*IPNIQQETLS
DFQGSGS*KLLHCIHRRSQWQWNLCKYRACRER
KTPSFE*QF*NCTVTKQK*RENT*NLLSQLIFK
NTAGRGGSRL*SQHFGRPRLADHLS
FCLF*SDCR
*SVSLS*GIKR*IHHVKNSWKWCLWRGKAGFRE
ENM*ESSHKDHQQKEVCYWFSKRGRPSSQC*NR
NRNFEKAKSSLHHQD*KLF*CRRLLYCFGIDGRG
RAV*QSGGE*TPERSYLQALFLPDALGCAVPS*
KRYYTP*LKARECFTVISRRGLSYKDY*FWALQ
DFGRDLSHENLMWNPHLLGA*SSCFCWDCWV*PC
CGLLEFRSYSFYLP*WVSTFL*A*DSSVTEGSD
HQWKIQLHS*SLGRSLRESSGPCQEVVGSGSKG
TFYDRRSLKTPVASG*RHEEKVSRSSV*GK*IHS
STPGSSPAFY*SKAAP*RGSRGCRDHKAPSCVC
CCVVNSVV*TRKKCTFFHSVIFLFFESVFL*FV
F*LWE*LLFHSH*CTIKNLMEPGLCASA**SVL*
LNGFIIYLFEMESHSVAQPE*SAVVQAWLTATS
ASQVQAILVPQPPE*LGLQVCTTMPVNFYIF

Frame 1

PSLPPARSVLPSRRPDLDVSLARARFPKPSLVP
VHKAEVVSSGVRCLQRSALWAEEPVLPPGAPWA
AAVPTAGIIASRLRRSIAA*RSPSGNPCRPKPPH
PEQSPGSPPPHLAGGLSSRGHSWGKAKRASNQT
NVADWLGSRGGGITRGEPGF*VPLSLLNYNSQE
ALRRRLTATSAAPHWSGGRGGGFDWLRVEFVSAG
LAPLCWLRLRRVCGSRWAHAVVMSRESDVEAQQ
SHGSSACSQPHGSVTQSQGSSSQSQGISSSSTS
TMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQ
EPEDQ
EPEEPTPAPWARLWALQDGFANLECVND
NYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHF
RIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKG
KRRPLNNNSEIALSLSRNKEKILKIYSLS*FSK
IRRGAVAHVFNPSTLGGRGWQIT*
VFVFFDLTV
DDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
KTCKKVAIKIISKRKFAIGSAREADPALNVETE
IEILKKLNHPCIIKIKNFFDAEDYYIVLELMEG
GELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHE
NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSK
ILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNR
AVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQI
TSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKA
RFTTEEALRHPWLQDEDMKRKFQDLLSEENEST
ALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
AVL*TPWFEHERNVPSFTLSSFFSLSLFFYSLY
FNYGNNCFFTVTDVQLKT*WNLGFVLLLDNRFF
S*MALLFIYLRWSLTLLPSLNEVQWCRLGSLQPL
LPRFKRFLCLSLLSSWDYRYAPPCLLIFIYF

Frame 2

LLFRQPDPSSPLAGQTSTCLSPGPVSRNRRSYQ
SIRLK*SRVGSGACSARHCGQKNLSSRPGPHGP
PQFQQRG*LLPACDAASQLSGLLLGTPVGQNPH
TRSKAPALPRHIWPAAYLAVVTRGEKQRERLTRL
MLLIGWGVEGAGSPEGNPGSKFRSPF*TTTPRR
H*GGA*RPHLLLLIGPAAGEGVLIG*GWSLYLQ
V*RHSAG*GCGECAAPGGLTRS*CLGSRMLRLSS
LMAAVPVHSPMAALPSPKAPPHSPRAYPAPLPA
RCQTPASPLTPALGH*AP*RQCPLRNSILFLRT
KNLRT
KNLRSLPLPPGLDYGPFRMDLPILNV*MT
TTGLGGTKAVNIALMNHC*KEQINTEHTARNTF
GFSGKWVLKTLTLHT*KITVAMEPL*IQSL*GK
ENAVL*ITILKLHCH*AEIKRKYLKSTLSADFQK
YGGARWLTSLIPALWEAEAGRSPE
FLSFLI*L*
MISQFILRH*EMNTSCQKLLEVVPVER*SWLSR
GKHVRK*P*RSSAKGSLLLVQQERQTQLSMLKQK
*KF*KS*IILASSRLKTFLMQKIIILFWN*WKG
ESCLTKWWGINA*KKLPASSIFTRCSWLCSTFM
KTVLYTVT*SQRMFYCHLKKRTVL*RLLILGTPR
FWERPLS*EPYVEPPPTWRLKFLFLLGLLGITV
LWTAGV*ELFFLSALVGIHLSLSIGLKCH*RIR
SPVENTTSFLKSGQKSQRKLWTLSRSCW*WIQRH
VLRQKKP*DTRGFRMKT*RESFKIFCLRKMNPQ
LYPRF*PSLLLVESGPVKGKPRVPRPQSAQLCV
LLCCELRGLNTKEMYLLSLCHLSFL*VCFFIVCI
LIMGIIAFSQSLMYN*KPDGTWALCFCLIIGSL
VEWLYYLFI*DGVSLCCPA*MKCSGAGLAHCNL
CFPGSSDSCASAS*VAGITGMHHHAC*FLYIL

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