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Sequences

Sequence INSR.bAug05

TCCCGCCGCCCGCCCGCCACCCGCCAGCCCAGGTGCCCGCCCGCCAGTCAGCTAGTCCGTCGGTCCGCGCGTCCCTCTGTCCCGGAGCCCGCAGATCGCG ACCCAGAGCGCGCGGGGCCGAGAGCCGAGAGACAGTCCCGGGCGCAGCGCGGAGCTCCGGGCCCCGAGATCCTGGGACGGGGCCCGGGCCGCAGCGGCCG GGGGGTCGGGGCCACCACCGCAAGGGCCTCCGCTCAGTATTTGTAGCTGGCGAAGCCGCGCGCGCCCTTCCCGGGGCTGCCTCTGGGCCCTCCCCGGCAG GGGGGCTGCGGCCCGCGGGTCGCGGGCGTGGAAGAGAAGGACGCGCGGCCCCCAGCGCCTCTTGGGTGGCCGCCTCGGAGCATGACCCCCGCGGGCCAGC GCCGCGCGCTCTGATCCGAGGAGACCCCGCGCTCCCGCAGCCATGGCCACCGGGGGCCGGCGGGGGGCGGCGGCCGCGCCGCTGCTGGTGGCGGTGGCCG CGCTGCTACTGGGCGCCGCGGGCCACCTGTACCCCGGAGAGGTGTGTCCCGGCATGGATATCCGGAACAACCTCACTAGGTTGCATGAGCTGGAGAATTG CTCTGTCATCGAAGGACACTTGCAGATACTCTTGATGTTCAAAACGAGGCCCGAAGATTTCCGAGACCTCAGTTTCCCCAAACTCATCATGATCACTGAT TACTTGCTGCTCTTCCGGGTCTATGGGCTCGAGAGCCTGAAGGACCTGTTCCCCAACCTCACGGTCATCCGGGGATCACGACTGTTCTTTAACTACGCGC TGGTCATCTTCGAGATGGTTCACCTCAAGGAACTCGGCCTCTACAACCTGATGAACATCACCCGGGGTTCTGTCCGCATCGAGAAGAACAATGAGCTCTG TTACTTGGCCACTATCGACTGGTCCCGTATCCTGGATTCCGTGGAGGATAATTACATCGTGTTGAACAAAGATGACAACGAGGAGTGTGGAGACATCTGT CCGGGTACCGCGAAGGGCAAGACCAACTGCCCCGCCACCGTCATCAACGGGCAGTTTGTCGAACGATGTTGGACTCATAGTCACTGCCAGAAAGTTTGCC CGACCATCTGTAAGTCACACGGCTGCACCGCCGAAGGCCTCTGTTGCCACAGCGAGTGCCTGGGCAACTGTTCTCAGCCCGACGACCCCACCAAGTGCGT GGCCTGCCGCAACTTCTACCTGGACGGCAGGTGTGTGGAGACCTGCCCGCCCCCGTACTACCACTTCCAGGACTGGCGCTGTGTGAACTTCAGCTTCTGC CAGGACCTGCACCACAAATGCAAGAACTCGCGGAGGCAGGGCTGCCACCAGTACGTCATTCACAACAACAAGTGCATCCCTGAGTGTCCCTCCGGGTACA CGATGAATTCCAGCAACTTGCTGTGCACCCCATGCCTGGGTCCCTGTCCCAAGGTGTGCCACCTCCTAGAAGGCGAGAAGACCATCGACTCGGTGACGTC TGCCCAGGAGCTCCGAGGATGCACCGTCATCAACGGGAGTCTGATCATCAACATTCGAGGAGGCAACAATCTGGCAGCTGAGCTAGAAGCCAACCTCGGC CTCATTGAAGAAATTTCAGGGTATCTAAAAATCCGCCGATCCTACGCTCTGGTGTCACTTTCCTTCTTCCGGAAGTTACGTCTGATTCGAGGAGAGACCT TGGAAATTGGGAACTACTCCTTCTATGCCTTGGACAACCAGAACCTAAGGCAGCTCTGGGACTGGAGCAAACACAACCTCACCATCACTCAGGGGAAACT CTTCTTCCACTATAACCCCAAACTCTGCTTGTCAGAAATCCACAAGATGGAAGAAGTTTCAGGAACCAAGGGGCGCCAGGAGAGAAACGACATTGCCCTG AAGACCAATGGGGACCAGGCATCCTGTGAAAATGAGTTACTTAAATTTTCTTACATTCGGACATCTTTTGACAAGATCTTGCTGAGATGGGAGCCGTACT GGCCCCCCGACTTCCGAGACCTCTTGGGGTTCATGCTGTTCTACAAAGAGGCCCCTTATCAGAATGTGACGGAGTTCGACGGGCAGGATGCGTGTGGTTC CAACAGTTGGACGGTGGTAGACATTGACCCACCCCTGAGGTCCAACGACCCCAAATCACAGAACCACCCAGGGTGGCTGATGCGGGGTCTCAAGCCCTGG ACCCAGTATGCCATCTTTGTGAAGACCCTGGTCACCTTTTCGGATGAACGCCGGACCTATGGGGCCAAGAGTGACATCATTTATGTCCAGACAGATGCCA CCAACCCCTCTGTGCCCCTGGATCCAATCTCAGTGTCTAACTCATCATCCCAGATTATTCTGAAGTGGAAACCACCCTCCGACCCCAATGGCAACATCAC CCACTACCTGGTTTTCTGGGAGAGGCAGGCGGAAGACAGTGAGCTGTTCGAGCTGGATTATTGCCTCAAAGGGCTGAAGCTGCCCTCGAGGACCTGGTCT CCACCATTCGAGTCTGAAGATTCTCAGAAGCACAACCAGAGTGAGTATGAGGATTCGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGATCC TGAAGGAGCTGGAGGAGTCCTCGTTTAGGAAGACGTTTGAGGATTACCTGCACAACGTGGTTTTCGTCCCCAGGCCATCTCGGAAACGCAGGTCCCTTGG CGATGTTGGGAATGTGACGGTGGCCGTGCCCACGGTGGCAGCTTTCCCCAACACTTCCTCGACCAGCGTGCCCACGAGTCCGGAGGAGCACAGGCCTTTT GAGAAGGTGGTGAACAAGGAGTCGCTGGTCATCTCCGGCTTGCGACACTTCACGGGCTATCGCATCGAGCTGCAGGCTTGCAACCAGGACACCCCTGAGG AACGGTGCAGTGTGGCAGCCTACGTCAGTGCGAGGACCATGCCTGAAGCCAAGGCTGATGACATTGTTGGCCCTGTGACGCATGAAATCTTTGAGAACAA CGTCGTCCACTTGATGTGGCAGGAGCCGAAGGAGCCCAATGGTCTGATCGTGCTGTATGAAGTGAGTTATCGGCGATATGGTGATGAGGAGCTGCATCTC TGCGTCTCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCTCCCTTGCGG GCAACGGCTCTTGGACGGAACCCACCTATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCGGCCCCCTCATCTTTGT CTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGGGACCGCTTTACGCTTCTTCAAACCCTGAG TATCTCAGTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTCGAGAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGG GCTCCTTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGGCAGAGACCCGCGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTCT CCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGGGCTTCACCTGCCATCACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCC ACGCTGGTGGTGATGGAGCTGATGGCTCACGGAGACCTGAAGAGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCCTGGCCGCCCTCCCCCTA CCCTTCAAGAGATGATTCAGATGGCGGCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAAGAAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTG CATGGTCGCCCATGATTTTACTGTCAAAATTGGAGACTTTGGAATGACCAGAGACATCTATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTC CCTGTACGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAATCACCAGCT TGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACAACTGTCCAGAGAGAGT CACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACCTGCTCAAGGACGACCTGCACCCCAGCTTT CCAGAGGTGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGGAGTTTGAGGACATGGAGAATGTGCCCCTGGACCGTT CCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGGGTTTCAAGCGGAGCTACGAGGAACACATCCCTTACACACACATGAA CGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCAATCCTTCCTAACAGTGCCTACCGTGGCGGGGGCGGGCAGGGGTTCCCATTTTCGCT TTCCTCTGGTTTGAAAGCCTCTGGAAAACTCAGGATTCTCACGACTCTACCATGTCCAATGGAGTTCAGAGATCGTTCCTATACATTTCTGTTCATCTTA AGGTGGACTCGTTTGGTTACCAATTTAACTAGTCCTGCAGAGGATTTAACTGTGAACCTGGAGGGCAAGGGGTTTCCACAGTTGCTGCTCCTTTGGGGCA ACGACGGTTTCAAACCAGGATTTTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAGCAGATGGAAAGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTT TTTTTTTTTTGCTGGTGTCTGAGCTTCAGTATAAAAGACAAAACTTCCTGTTTGTGGAACAAAAGTTCGAAAGAAAAAACAAAACAAAAACACCCAGCCC TGTTCCAGGAGAATTTCAAGTTTTACAGGTTGAGCTTCAAGATGGTTTTTTTGGTTTTTTTTTTTTCTCTCATCCAGGCTGAAGGATTTTTTTTTTCTTT ACAAAATGAGTTCCTCAAATTGACCAATAGCTGCTGCTTTCATATTTTGGATAAGGGTCTGTGGTCCCGGCGTGTGCTCACGTGTGTATGCACGTGTGTG TGTCCATTAGACACGGCTGATGTGTGTGCAAAGTATCCATGCGGAGTTGATGCTTTGGGAATTGGCTCATGAAGGTTCTTCTCAAGGGTGCGAGCTCATC CCCCTCTCTCCTTCCTTCTTATTGACTGGGAGACTGTGCTCTCGACAGATTCTTCTTGTGTCAGAAGTCTAGCCTCAGGTTTCTACCCTCCCTTCACATT GGTGGCCAAGGGAGGAGCATTTCATTTGGAGTGATTATGAATCTTTTCAAGACCAAACCAAGCTAGGACATTAAAAAAAAAAAAAGAAAAAGAAAGAAAA AACAAAATGGAAAAAGGAAAAAAAAAAAGAACTGAGATGACAGAGTTTTGAGAATATATTTGTACCATATTTAATTTTTAAAGTCTCTGGTATTAGCCTC ATAAGTTATTGACTATTCCCCGGGGTTGGCGGGGAGTGGGGACATGAGTTGGTCTGCCTGTTGTGGGGCCGGGAAGGGGAGGGAGTCAGGCACAAGTGGC CTCTTTGTTTGGTCTTAAAGGCATCCATTTCTGGGAATGAAGCCATGTTCGCTGCTAACACTTTTGGATGTTGTGAGGCCACGTGGAGTGTGTGAGAGAC TAGGTTTTATGGATGGTCTGGTTCAGGTACCAGGTCTGCTGGAAGGTTCCTGTTCGGATAAGCTGGTAGCTACCTAGCTCTGAGCCTGCCTTCAAGAACA CCTGTGTTCATCCTCTGATTCTCTGTGTGTACCTCTTGTGGCGTTTCCTCTCCCGGGTGTGAACATCCTAACCGTTATTGTGCAAACCCAAGAACGTCAG ATCCCAAAGCACAACAACCTGGATGGACTTTGGGAACATCTAAGCAATGTAAGAGAGAGGTGCACTGAGAGTACGTCTTGGTCCCCTCCACCCTGAGAGC ATCTGACGGTCCTCAGTACTGAACTCCCGGAAGCTGCTCTGAGCCCGGTGACCTCATCTGGGCCAGGTGTGGTGCCTGAGCTGAATGCTCAGGTGCTTAC AGTGTTGCAATCCCTAAGAGAGTAGAGTCTGGAGGAGAAACCGTGAAAAAGACCTTACACACCACCAAGAACTTCCGAATGGGCGTGAATCCACCGTTTC TTCTCTTTGCAAAAAGAACCACCACAGCTGCTCAAAGAACACAGTGAACTCATCACTTTGGTTCATCAAAAAATCATCGCCCATGCGTTATTCCTGAGTG CATTTTCTTACAACTTTTTGACTGCTTCCTTTTCTTCTTCTCTTAAGAGTTGTGGGCTTAAGAATGGGATAGAGTCATAATGGCAACCTCCAAGCCCTCT CAATTCTTGATTAAGAACACAGGTAGACATGAATCCCAATTGTCTATTGCTATCTTATTTATATGATTCGGGAAAATACAGCATGTAAAAATATTGCTGA GGAGCCTCAGTGATTGGGTACAAGAAGCAAGAGTACAGAAATTATTTTTGCCAAATTTATTTTGTAAATATGAGGGTCTGTACCTAAATTTAAAAAAAAA ACACGTAGAACTAGGTATTTTGTTCTCTTCTTAGTAAATTTGTAGTGGTTGTATACTACACTAGCTGCAATTTTCACATTTTTCTAATTCAGAAAGGTTT TTCTTATATTAGGGGAAAAAGTATTTATTTTAATATATAAAATCACTCTGAAAATCACTCTCATAAAAAATGGAGCGCATGTAAATTTTTATCAAAGAAA AATAAACAGGTGAATGGGGGATAGTGATTTTCTTTTTTCAGCACAGTCTACCTCAGTGTATTGTTAAGATGTGATTCAATCATGGACATCTTTGAGATTT CAGAATTCTACCTGGAACCGGTCTGAATCAGGGAACGTGTGTATCAGCTGATTCGAATGCCAGGGACCAGTAAGAATTTTGAGGGAGGGAGTTGGGATGG AGAAGGTATGGCCTTTATGCGAGCATAGATCCTTTTCTTCCTGGCTGGTAATATTCTTCTCTGAATTTAATCTTCCTTTAAAAAAAAATCCTCCATCTAT TGTCACTATGTTCCCCAAACATAAACTAAGTTCCAGGCTGTCATGATGTATCTGATATATGGGGTAACCCAGCAAGGTGTACCTTCCTTTGGTGAGAGAT GGCTGCCGGGGCAAAGACGGGCTTTGATTCAGAGCAAGCATTCCCACCTGTTCCATGGAATCCCCCTGAAGTGAGCACAAAGGTGCCCTGGGCTCCCTGA TGGTTTATGCCCACTCCTTTCAGGCTGGTGATGCACCTTACACACAAACACCTAATGCAATGTCTTTTTAAATTCTCCAAGTGGGATGGGAGCATGTGAG GGAAATTCCAATCCAAAACCCATTAATGTGCTGAACGCTTTTTTTTTTTTTTTTTTTTTTTTTGCAACAACACCTTGGACCTCTGTGTTGGGGTTTGACT GACCTCAAGCTGATATTATTGGACCTTGTGCAGCTTTGATAACCCATGTGAGAGTCTAGGCAGGACCAGTGGGGCCCAAATCTTGCTGCTCTTGTACTTT TAGGCACTGCCCTTGCAGACTCACCTTTCTCCACCTGCCCTGGAGAAAGGTAGGGTGTGCTGGGCCTGCCCCTTGCAAATGGGATTCACCAGTTTCATTT ATTTGACTCTACTGCCACAGTGAAAAGAGCAAACAGCTATTGGGTTGCAAACCTCCTTTGACATTAGGAAATGTTGACTTTGTAACAATAAAACTTTGGT CCTAGAAAGACACGGTTGTCCTGGGAGTTTGTAGTGTTAAGTTGCAACAACAACAACAAAAAGCAACAAAACCAGCTTAGGATAACACTTTTTGTTGCTT GTTCTTAAAGATGTCTCACTATGATTAAAACCCTTTTCATTAATGTAGTGAAAGCCACACAGGAGTTCCTTCTTCCAGGAGGAGAATACCAAGCACATCA CTTTCTCTCTGCATCAGTGATGTCAAATACGCATCAGAAAATGTTCAGGTTTTAGGAGCTGTCCTAGGTGCTGTTTCATCATTGGAAGCAGTGAGAAAGA GAAGCACTGCTGCTTGTCTGGATATAGGCTGAGGATGATTGAGAGAAGCTGTGGGAACTGACACAAGGGTCTGCATAGGTCATCCTGTGACCCTGGGGAC TATGTTACCAACTGACAGACAGATCTTTCACTGTATCCTAGCAGGGCAGGTAGTCCACCAAGAAATGTGCTTATTGGATTGGGAGGTGTTTATTTGTAGT CTGCTGTAACACGTGTGAAAGAGCAGGAGCGTCATCAGCATATGACTTGCGCTGGTCATCCGGTAAATGGATGTGCTGTAGTCCCAGTGCTAATCATTTC TCTCCTTCACAGTGGGTGGAAGTTTAGGGTTAAATGTCCTTTGAATGTCACCTGGTGAGTCCTTGACACCTTAGGCTCTTCAGAAACAATGGTTTTGTTG AGGATGGGGAACAGGGAATGCCGATTTTATATACATGGTACACAGAGAGGGGTGTCACTTCAGAAAATCTTCCAGCATGTTCTTCAGAATATTAATTTAT ATGCGAGGTGAGGTTGGGAATGAAAAGAACAGGTCAGCACTTTTTTTTTTCCTAGAACATACAAAAGAACATGGTGGACTTTCAGGGAGTGCAATGGAAG GTGAATATTTCCTTAAGGGTCCCCGAGAAATGGGAGTGAGGGGAGGGGACACAATGGCTTTTTGAGCTTACTTTTACCTTCTGATACTAGTCAAGGTCCA GAACCAGCCACCAGCCAAATTTCTATCTGGGTGCGGGCCACTGAAAATCCTTGTTAAAAACCAGATCACAAATCTGGGGCTCTTGGTCCCATTGGAGAAG GAAGGAAGAGCCTCAAAATAAGTGTGCACCCATGCACATATTCAGGAACAGCTTGTTTAGTCTTTACACTTTGCCTGAAAGTTGCTTCTCCTCGTCCCTT TGTGTGCCTGGGTGGCCTCGGCCCTGTGCGTTGGCAACGCAGGATCAAATGTGCTGCAGCTTTTGCAGAAAACAACTCAGAAACACAAAACCCCCCAACA GCTCAATTATTATTTTTTCAATGTTTTCCTACAAGAGCCAAGTAGCACCATGTACAGAAGACGCCTTTTTTTTTGGAATATTGAAATCGTTCTGCATGTA AAATATGGGATAATGACCTGTTTATATTAAAATTCTGATTAAATTATCTGAGAATA

INSR.u.f.15 (forward primer)
INSR.u.r.18 (reverse primer)
Single exon skipping

Frame 0

SRRPPATRQPRCPPASQLVRRSARPSVPEPADR DPERAGPRAERQSRAQRGAPGPEILGRGPGRSGR GVGATTARASAQYL*LAKPRAPFPGLPLGPPRQ GGCGPRVAGVEEKDARPPAPLGWPPRSMTPAGQ RRAL*SEETPRSRSHGHRGPAGGGGRAAAGGGGR AATGRRGPPVPRRGVSRHGYPEQPH*VA*AGEL LCHRRTLADTLDVQNEARRFPRPQFPQTHHDH* LLAALPGLWAREPEGPVPQPHGHPGITTVL*LRA GHLRDGSPQGTRPLQPDEHHPGFCPHREEQ*AL LLGHYRLVPYPGFRGG*LHRVEQR*QRGVWRHL SGYREGQDQLPRHRHQRAVCRTMLDS*SLPESLP DHL*VTRLHRRRPLLPQRVPGQLFSARRPHQVR GLPQLLPGRQVCGDLPAPVLPLPGLALCELQLL PGPAPQMQELAEAGLPPVRHSQQQVHP*VSLRVH DEFQQLAVHPMPGSLSQGVPPPRRREDHRLGDV CPGAPRMHRHQRESDHQHSRRQQSGS*ARSQPR PH*RNFRVSKNPPILRSGVTFLLPEVTSDSRRDL GNWELLLLCLGQPEPKAALGLEQTQPHHHSGET LLPL*PQTLLVRNPQDGRSFRNQGAPGEKRHCP EDQWGPGIL*K*VT*IFLHSDIF*QDLAEMGAVL APRLPRPLGVHAVLQRGPLSECDGVRRAGCVWF QQLDGGRH*PTPEVQRPQITEPPRVADAGSQAL DPVCHLCEDPGHLFG*TPDLWGQE*HHLCPDRCH QPLCAPGSNLSV*LIIPDYSEVETTLRPQWQHH PLPGFLGEAGGRQ*AVRAGLLPQRAEAALEDLV STIRV*RFSEAQPE*V*GFGRRMLLLSKDRLSDP EGAGGVLV*EDV*GLPAQRGFRPQAISETQVPW RCWECDGGRAHGGSFPQHFLDQRAHESGGAQAF *EGGEQGVAGHLRLATLHGLSHRAAGLQPGHP*G TVQCGSLRQCEDHA*SQG**HCWPCDA*NL*EQ RRPLDVAGAEGAQWSDRAV*SELSAIW**GAAS LRLPQALRSGTGLQAAWAVTGELQRANPGHLPCG QRLLDGTHLFLRDRLFRRPVKYCKNYHRPPHLC LSLQCCDWKYLSIPEKEAARWAAGTALRFFKP* VSQCQ*CVSMLCVRAGRVGGVSREDHPPSRAGAG LLRHGV*GQCQGHHQG*GRDPRGGEDGQRVSQS PRAD*VPQ*GLGHEGLHLPSRGAPPGSGVQGPA HAGGDGADGSRRPEELPPFSAARG*E*SWPPSPY PSRDDSDGGRDC*RDGLPERQEVCASGPGSEKL HGRP*FYCQNWRLWNDQRHL*NGLLPERGQGSA PCTVDGTGVPEGWGLHHFF*HVVLWRGPLGNHQL GRTALPRPV**TGVEICHGWRVSGSTRQLSRES H*PHAHVLAIQPQDEANLPGDCQPAQGRPAPQL SRGVVLPQRGEQGSRE*GAGDGV*GHGECAPGPF LALSEGGGGGPGWRVLAGFQAELRGTHPLHTHE RRQEKRADSDLASVQSFLTVPTVAGAGRGSHFR FPLV*KPLENSGFSRLYHVQWSSEIVPIHFCSS* GGLVWLPI*LVLQRI*L*TWRARGFHSCCSFGA TTVSNQDFVFFRSPHPPPADGKKAPVFTNSFFF FFFLLVSELQYKRQNFLFVEQKFERKNKTKTPSP VPGEFQVLQVELQDGFFGFFFFSHPG*RIFFFF TK*VPQIDQ*LLLSYFG*GSVVPACAHVCMHVC VSIRHG*CVCKVSMRS*CFGNWLMKVLLKGASSS PSLLPSY*LGDCALDRFFLCQKSSLRFLPSLHI GGQGRSISFGVIMNLFKTKPS*DIKKKKRKRKK KQNGKRKKKKN*DDRVLRIYLYHI*FLKSLVLAS *VIDYSPGLAGSGDMSWSACCGAGKGRESGTSG LFVWS*RHPFLGMKPCSLLTLLDVVRPRGVCER LGFMDGLVQVPGLLEGSCSDKLVAT*L*ACLQEH LCSSSDSLCVPLVAFPLPGVNILTVIVQTQERQ IPKHNNLDGLWEHLSNVRERCTESTSWSPPP*E HLTVLSTELPEAALSPVTSSGPGVVPELNAQVLT VLQSLRE*SLEEKP*KRPYTPPRTSEWA*IHRF FSLQKEPPQLLKEHSELITLVHQKIIAHALFLS AFSYNFLTASFSSSLKSCGLKNGIES*WQPPSPL NS*LRTQVDMNPNCLLLSYLYDSGKYSM*KYC* GASVIGYKKQEYRNYFCQIYFVNMRVCT*I*KK NT*N*VFCSLLSKFVVVVYYTSCNFHIFLIQKGF SYIRGKSIYFNI*NHSENHSHKKWSACKFLSKK NKQVNGG**FSFFSTVYLSVLLRCDSIMDIFEI SEFYLEPV*IRERVYQLIRMPGTSKNFEGGSWDG EGMAFMRA*ILFFLAGNILL*I*SSFKKKSSIY CHYVPQT*TKFQAVMMYLIYGVTQQGVPSFGER WLPGQRRALIQSKHSHLFHGIPLK*AQRCPGLPD GLCPLLSGW*CTLHTNT*CNVFLNSPSGMGACE GNSNPKPINVLNAFFFFFFFFATTPWTSVLGFD *PQADIIGPCAALITHVRV*AGPVGPKSCCSCTF RHCPCRLTFLHLPWRKVGCAGPAPCKWDSPVSF I*LYCHSEKSKQLLGCKPPLTLGNVDFVTIKLW S*KDTVVLGVCSVKLQQQQQKATKPA*DNTFCCL FLKMSHYD*NPFH*CSESHTGVPSSRRRIPSTS LSLCISDVKYASENVQVLGAVLGAVSSLEAVRK RSTAACLDIG*G*LREAVGTDTRVCIGHPVTLGT MLPTDRQIFHCILAGQVVHQEMCLLDWEVFICS LL*HV*KSRSVISI*LALVIR*MDVL*SQC*SF LSFTVGGSLGLNVL*MSPGESLTP*ALQKQWFC* GWGTGNADFIYMVHREGCHFRKSSSMFFRILIY MRGEVGNEKNRSALFFFLEHTKEHGGLSGSAME GEYFLKGPREMGVRGGDTMAF*AYFYLLILVKVQ NQPPAKFLSGCGPLKILVKNQITNLGLLVPLEK EGRASK*VCTHAHIQEQLV*SLHFA*KLLLLVP LCAWVASALCVGNAGSNVLQLLQKTTQKHKTPQQ LNYYFFNVFLQEPSSTMYRRRLFFWNIEIVLHV KYGIMTCLY*NSD*II*E

Frame 1

PAARPPPASPGARPPVS*SVGPRVPLSRSPQIA TQSARGREPRDSPGRSAELRAPRSWDGARAAAA GGSGPPPQGPPLSICSWRSRARPSRGCLWALPGR GAAARGSRAWKRRTRGPQRLLGGRLGA*PPRAS AARSDPRRPRAPAAMATGGRRGAAAAPLLVAVA ALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENC SVIEGHLQILLMFKTRPEDFRDLSFPKLIMITD YLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYA LVIFEMVHLKELGLYNLMNITRGSVRIEKNNELC YLATIDWSRILDSVEDNYIVLNKDDNEECGDIC PGTAKGKTNCPATVINGQFVERCWTHSHCQKVC PTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCV ACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFC QDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGY TMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTS AQELRGCTVINGSLIINIRGGNNLAAELEANLG LIEEISGYLKIRRSYALVSLSFFRKLRLIRGET LEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKL FFHYNPKLCLSEIHKMEEVSGTKGRQERNDIAL KTNGDQASCENELLKFSYIRTSFDKILLRWEPY WPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGS NSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPW TQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDA TNPSVPLDPISVSNSSSQIILKWKPPSDPNGNIT HYLVFWERQAEDSELFELDYCLKGLKLPSRTWS PPFESEDSQKHNQSEYEDSAGECCSCPKTDSQI LKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLG DVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPF EKVVNKESLVISGLRHFTGYRIELQACNQDTPE ERCSVAAYVSARTMPEAKADDIVGPVTHEIFENN VVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHL CVSRKHFALERGCRLRGLSPGNYSVRIRATSLA GNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFV FLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPE YLSASDVFPCSVYVPDEWEVSREKITLLRELGQ GSFGMVYEGNARDIIKGEAETRVAVKTVNESASL RERIEFLNEASVMKGFTCHHVVRLLGVVSKGQP TLVVMELMAHGDLKSYLRSLRPEAENNPGRPPP TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNC MVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLL PVRWMAPESLKDGVFTTSSDMWSFGVVLWEITS LAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERV TDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSF PEVSFFHSEENKAPESEELEMEFEDMENVPLDR SSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMN GGKKNGRILTLPRSNPS*QCLPWRGRAGVPIFA FLWFESLWKTQDSHDSTMSNGVQRSFLYISVHL KVDSFGYQFN*SCRGFNCEPGGQGVSTVAAPLGQ RRFQTRILCFFVPPTRPQQMERKHLFLQILFFF FFFCWCLSFSIKDKTSCLWNKSSKEKTKQKHPA LFQENFKFYRLSFKMVFLVFFFSLIQAEGFFFSL QNEFLKLTNSCCFHILDKGLWSRRVLTCVCTCV CPLDTADVCAKYPCGVDALGIGS*RFFSRVRAH PPLSFLLIDWETVLSTDSSCVRSLASGFYPPFTL VAKGGAFHLE*L*IFSRPNQARTLKKKKEKERK NKMEKGKKKRTEMTEF*EYICTIFNF*SLWY*P HKLLTIPRGWRGVGT*VGLPVVGPGRGGSQAQVA SLFGLKGIHFWE*SHVRC*HFWML*GHVECVRD *VLWMVWFRYQVCWKVPVRISW*LPSSEPAFKN TCVHPLILCVYLLWRFLSRV*TS*PLLCKPKNVR SQSTTTWMDFGNI*AM*ERGALRVRLGPLHPES I*RSSVLNSRKLL*AR*PHLGQVWCLS*MLRCL QCCNP*ESRVWRRNREKDLTHHQELPNGRESTVS SLCKKNHHSCSKNTVNSSLWFIKKSSPMRYS*V HFLTTF*LLPFLLLLRVVGLRMG*SHNGNLQAL SILD*EHR*T*IPIVYCYLIYMIRENTACKNIAE EPQ*LGTRSKSTEIIFAKFIL*I*GSVPKFKKK TRRTRYFVLFLVNL*WLYTTLAAIFTFF*FRKV FLILGEKVFILIYKITLKITLIKNGAHVNFYQRK INR*MGDSDFLFSAQSTSVYC*DVIQSWTSLRF QNSTWNRSESGNVCIS*FECQGPVRILREGVGM EKVWPLCEHRSFSSWLVIFFSEFNLPLKKNPPSI VTMFPKHKLSSRLS*CI*YMG*PSKVYLPLVRD GCRGKDGL*FRASIPTCSMESP*SEHKGALGSL MVYAHSFQAGDAPYTQTPNAMSF*ILQVGWEHVR EIPIQNPLMC*TLFFFFFFFLQQHLGPLCWGLT DLKLILLDLVQL**PM*ESRQDQWGPNLAALVL LGTALADSPFSTCPGER*GVLGLPLANGIHQFHL FDSTATVKRANSYWVANLL*H*EMLTL*Q*NFG PRKTRLSWEFVVLSCNNNNKKQQNQLRITLFVA CS*RCLTMIKTLFINVVKATQEFLLPGGEYQAHH FLSASVMSNTHQKMFRF*ELS*VLFHHWKQ*ER EALLLVWI*AEDD*EKLWELTQGSA*VIL*PWG LCYQLTDRSFTVS*QGR*STKKCAYWIGRCLFVV CCNTCERAGASSAYDLRWSSGKWMCCSPSANHF SPSQWVEV*G*MSFECHLVSP*HLRLFRNNGFV EDGEQGMPILYTWYTERGVTSENLPACSSEY*FI CEVRLGMKRTGQHFFFS*NIQKNMVDFQGVQWK VNISLRVPEKWE*GEGTQWLFELTFTF*Y*SRS RTSHQPNFYLGAGH*KSLLKTRSQIWGSWSHWRR KEEPQNKCAPMHIFRNSLFSLYTLPESCFSSSL CVPGWPRPCALATQDQMCCSFCRKQLRNTKPPN SSIIIFSMFSYKSQVAPCTEDAFFFGILKSFCM* NMG**PVYIKILIKLSEN

Frame 2

PPPARHPPAQVPARQSASPSVRASLCPGARRSR PRARGAESRETVPGAARSSGPRDPGTGPGPQRP GGRGHHRKGLRSVFVAGEAARALPGAASGPSPA GGLRPAGRGRGREGRAAPSASWVAASEHDPRGPA PRALIRGDPALPQPWPPGAGGGRRPRRCWWRWP RCYWAPRATCTPERCVPAWISGTTSLGCMSWRI ALSSKDTCRYS*CSKRGPKISETSVSPNSS*SLI TCCSSGSMGSRA*RTCSPTSRSSGDHDCSLTTR WSSSRWFTSRNSASTT**TSPGVLSASRRTMSS VTWPLSTGPVSWIPWRIITSC*TKMTTRSVETSV RVPRRARPTAPPPSSTGSLSNDVGLIVTARKFA RPSVSHTAAPPKASVATASAWATVLSPTTPPSA WPAATSTWTAGVWRPARPRTTTSRTGAV*TSASA RTCTTNARTRGGRAATSTSFTTTSASLSVPPGT R*IPATCCAPHAWVPVPRCATS*KARRPSTR*R LPRSSEDAPSSTGV*SSTFEEATIWQLS*KPTSA SLKKFQGI*KSADPTLWCHFPSSGSYV*FEERP WKLGTTPSMPWTTRT*GSSGTGANTTSPSLRGN SSSTITPNSACQKSTRWKKFQEPRGARRETTLP* RPMGTRHPVKMSYLNFLTFGHLLTRSC*DGSRT GPPTSETSWGSCCSTKRPLIRM*RSSTGRMRVV PTVGRW*TLTHP*GPTTPNHRTTQGG*CGVSSPG PSMPSL*RPWSPFRMNAGPMGPRVTSFMSRQMP PTPLCPWIQSQCLTHHPRLF*SGNHPPTPMATS PTTWFSGRGRRKTVSCSSWIIASKG*SCPRGPGL HHSSLKILRSTTRVSMRIRPANAAPVQRQTLRS *RSWRSPRLGRRLRITCTTWFSSPGHLGNAGPL AMLGM*RWPCPRWQLSPTLPRPACPRVRRSTGLL RRW*TRSRWSSPACDTSRAIASSCRLATRTPLR NGAVWQPTSVRGPCLKPRLMTLLAL*RMKSLRT TSST*CGRSRRSPMV*SCCMK*VIGDMVMRSCIS ASPASTSLWNGAAGCVGCHRGTTACESGPPPLR ATALGRNPPIST*QTI*TSRQILQKLSSAPSSL SFSSVL*LEVFIYS*ERGSQMGRWDRFTLLQTLS ISVPVMCFHALCTCRTSGRCLERRSPSFESWGR APSAWCMRAMPGTSSRVRQRPAWR*RRSTSQPV SESGLSSSMRPRS*RASPAITWCASWEWCPRASP RWW*WS*WLTET*RATSVLCGQRLRIILAALPL PFKR*FRWRQRLLTGWPT*TPRSLCIGTWQRET AWSPMILLSKLETLE*PETSMKRITTGKGARVCS LYGGWHRSP*RMGSSPLLLTCGPLAWSFGKSPA WQNSLTKACLMNRC*NLSWMEGIWINPTTVQRE SLTSCACAGNSTPR*GQPSWRLSTCSRTTCTPAF QRCRSSTARRTRLPRVRSWRWSLRTWRMCPWTV PRTVRGRRRGAGMEGPRWVSSGATRNTSLTHT* TEARKTGGF*PCLGPILPNSAYRGGGGQGFPFSL SSGLKASGKLRILTTLPCPMEFRDRSYTFLFIL RWTRLVTNLTSPAEDLTVNLEGKGFPQLLLLWG NDGFKPGFCVFSFPPPAPSRWKESTCFYKFFFFF FFFAGV*ASV*KTKLPVCGTKVRKKKQNKNTQP CSRRISSFTG*ASRWFFWFFFFLSSRLKDFFFL YKMSSSN*PIAAAFIFWIRVCGPGVCSRVYARVC VH*TRLMCVQSIHAELMLWELAHEGSSQGCELI PLSPSFLLTGRLCSRQILLVSEV*PQVSTLPSH WWPREEHFIWSDYESFQDQTKLGH*KKKKKKKEK TKWKKEKKKELR*QSFENIFVPYLIFKVSGISL ISY*LFPGVGGEWGHELVCLLWGREGEGVRHKW PLCLVLKASISGNEAMFAANTFGCCEATWSV*ET RFYGWSGSGTRSAGRFLFG*AGSYLALSLPSRT PVFIL*FSVCTSCGVSSPGCEHPNRYCANPRTS DPKAQQPGWTLGTSKQCKREVH*EYVLVPSTLRA SDGPQY*TPGSCSEPGDLIWARCGA*AECSGAY SVAIPKRVESGGETVKKTLHTTKNFRMGVNPPF LLFAKRTTTAAQRTQ*THHFGSSKNHRPCVIPEC IFLQLFDCFLFFFS*ELWA*EWDRVIMATSKPS QFLIKNTGRHESQLSIAILFI*FGKIQHVKILL RSLSDWVQEARVQKLFLPNLFCKYEGLYLNLKKK HVELGILFSS**ICSGCILH*LQFSHFSNSERF FLY*GKKYLF*YIKSL*KSLS*KMERM*IFIKE K*TGEWGIVIFFFQHSLPQCIVKM*FNHGHL*DF RILPGTGLNQGTCVSADSNARDQ*EF*GRELGW RRYGLYASIDPFLPGW*YSSLNLIFL*KKILHL LSLCSPNIN*VPGCHDVSDIWGNPARCTFLW*EM AAGAKTGFDSEQAFPPVPWNPPEVSTKVPWAP* WFMPTPFRLVMHLTHKHLMQCLFKFSKWDGSM* GKFQSKTH*CAERFFFFFFFFCNNTLDLCVGV*L TSS*YYWTLCSFDNPCESLGRTSGAQILLLLYF *ALPLQTHLSPPALEKGRVCWACPLQMGFTSFI YLTLLPQ*KEQTAIGLQTSFDIRKC*LCNNKTLV LERHGCPGSL*C*VATTTTKSNKTSLG*HFLLL VLKDVSL*LKPFSLM**KPHRSSFFQEENTKHI TFSLHQ*CQIRIRKCSGFRSCPRCCFIIGSSEKE KHCCLSGYRLRMIERSCGN*HKGLHRSSCDPGD YVTN*QTDLSLYPSRAGSPPRNVLIGLGGVYL* SAVTRVKEQERHQHMTCAGHPVNGCAVVPVLIIS LLHSGWKFRVKCPLNVTW*VLDTLGSSETMVLL RMGNRECRFYIHGTQRGVSLQKIFQHVLQNINL YAR*GWE*KEQVSTFFFPRTYKRTWWTFRECNGR *IFP*GSPRNGSEGRGHNGFLSLLLPSDTSQGP EPATSQISIWVRATENPC*KPDHKSGALGPIGE GRKSLKISVHPCTYSGTACLVFTLCLKVASPRPF VCLGGLGPVRWQRRIKCAAAFAENNSETQNPPT AQLLFFQCFPTRAK*HHVQKTPFFLEY*NRSAC KIWDNDLFILKF*LNYLRI

Sequence INSR.aAug05

TCCCGCCGCCCGCCCGCCACCCGCCAGCCCAGGTGCCCGCCCGCCAGTCAGCTAGTCCGTCGGTCCGCGCGTCCCTCTGTCCCGGAGCCCGCAGATCGCG ACCCAGAGCGCGCGGGGCCGAGAGCCGAGAGACAGTCCCGGGCGCAGCGCGGAGCTCCGGGCCCCGAGATCCTGGGACGGGGCCCGGGCCGCAGCGGCCG GGGGGTCGGGGCCACCACCGCAAGGGCCTCCGCTCAGTATTTGTAGCTGGCGAAGCCGCGCGCGCCCTTCCCGGGGCTGCCTCTGGGCCCTCCCCGGCAG GGGGGCTGCGGCCCGCGGGTCGCGGGCGTGGAAGAGAAGGACGCGCGGCCCCCAGCGCCTCTTGGGTGGCCGCCTCGGAGCATGACCCCCGCGGGCCAGC GCCGCGCGCTCTGATCCGAGGAGACCCCGCGCTCCCGCAGCCATGGCCACCGGGGGCCGGCGGGGGGCGGCGGCCGCGCCGCTGCTGGTGGCGGTGGCCG CGCTGCTACTGGGCGCCGCGGGCCACCTGTACCCCGGAGAGGTGTGTCCCGGCATGGATATCCGGAACAACCTCACTAGGTTGCATGAGCTGGAGAATTG CTCTGTCATCGAAGGACACTTGCAGATACTCTTGATGTTCAAAACGAGGCCCGAAGATTTCCGAGACCTCAGTTTCCCCAAACTCATCATGATCACTGAT TACTTGCTGCTCTTCCGGGTCTATGGGCTCGAGAGCCTGAAGGACCTGTTCCCCAACCTCACGGTCATCCGGGGATCACGACTGTTCTTTAACTACGCGC TGGTCATCTTCGAGATGGTTCACCTCAAGGAACTCGGCCTCTACAACCTGATGAACATCACCCGGGGTTCTGTCCGCATCGAGAAGAACAATGAGCTCTG TTACTTGGCCACTATCGACTGGTCCCGTATCCTGGATTCCGTGGAGGATAATTACATCGTGTTGAACAAAGATGACAACGAGGAGTGTGGAGACATCTGT CCGGGTACCGCGAAGGGCAAGACCAACTGCCCCGCCACCGTCATCAACGGGCAGTTTGTCGAACGATGTTGGACTCATAGTCACTGCCAGAAAGTTTGCC CGACCATCTGTAAGTCACACGGCTGCACCGCCGAAGGCCTCTGTTGCCACAGCGAGTGCCTGGGCAACTGTTCTCAGCCCGACGACCCCACCAAGTGCGT GGCCTGCCGCAACTTCTACCTGGACGGCAGGTGTGTGGAGACCTGCCCGCCCCCGTACTACCACTTCCAGGACTGGCGCTGTGTGAACTTCAGCTTCTGC CAGGACCTGCACCACAAATGCAAGAACTCGCGGAGGCAGGGCTGCCACCAGTACGTCATTCACAACAACAAGTGCATCCCTGAGTGTCCCTCCGGGTACA CGATGAATTCCAGCAACTTGCTGTGCACCCCATGCCTGGGTCCCTGTCCCAAGGTGTGCCACCTCCTAGAAGGCGAGAAGACCATCGACTCGGTGACGTC TGCCCAGGAGCTCCGAGGATGCACCGTCATCAACGGGAGTCTGATCATCAACATTCGAGGAGGCAACAATCTGGCAGCTGAGCTAGAAGCCAACCTCGGC CTCATTGAAGAAATTTCAGGGTATCTAAAAATCCGCCGATCCTACGCTCTGGTGTCACTTTCCTTCTTCCGGAAGTTACGTCTGATTCGAGGAGAGACCT TGGAAATTGGGAACTACTCCTTCTATGCCTTGGACAACCAGAACCTAAGGCAGCTCTGGGACTGGAGCAAACACAACCTCACCATCACTCAGGGGAAACT CTTCTTCCACTATAACCCCAAACTCTGCTTGTCAGAAATCCACAAGATGGAAGAAGTTTCAGGAACCAAGGGGCGCCAGGAGAGAAACGACATTGCCCTG AAGACCAATGGGGACCAGGCATCCTGTGAAAATGAGTTACTTAAATTTTCTTACATTCGGACATCTTTTGACAAGATCTTGCTGAGATGGGAGCCGTACT GGCCCCCCGACTTCCGAGACCTCTTGGGGTTCATGCTGTTCTACAAAGAGGCCCCTTATCAGAATGTGACGGAGTTCGACGGGCAGGATGCGTGTGGTTC CAACAGTTGGACGGTGGTAGACATTGACCCACCCCTGAGGTCCAACGACCCCAAATCACAGAACCACCCAGGGTGGCTGATGCGGGGTCTCAAGCCCTGG ACCCAGTATGCCATCTTTGTGAAGACCCTGGTCACCTTTTCGGATGAACGCCGGACCTATGGGGCCAAGAGTGACATCATTTATGTCCAGACAGATGCCA CCAACCCCTCTGTGCCCCTGGATCCAATCTCAGTGTCTAACTCATCATCCCAGATTATTCTGAAGTGGAAACCACCCTCCGACCCCAATGGCAACATCAC CCACTACCTGGTTTTCTGGGAGAGGCAGGCGGAAGACAGTGAGCTGTTCGAGCTGGATTATTGCCTCAAAGGGCTGAAGCTGCCCTCGAGGACCTGGTCT CCACCATTCGAGTCTGAAGATTCTCAGAAGCACAACCAGAGTGAGTATGAGGATTCGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGATCC TGAAGGAGCTGGAGGAGTCCTCGTTTAGGAAGACGTTTGAGGATTACCTGCACAACGTGGTTTTCGTCCCCAGAAAAACCTCTTCAGGCACTGGTGCCGA GGACCCTAGGCCATCTCGGAAACGCAGGTCCCTTGGCGATGTTGGGAATGTGACGGTGGCCGTGCCCACGGTGGCAGCTTTCCCCAACACTTCCTCGACC AGCGTGCCCACGAGTCCGGAGGAGCACAGGCCTTTTGAGAAGGTGGTGAACAAGGAGTCGCTGGTCATCTCCGGCTTGCGACACTTCACGGGCTATCGCA TCGAGCTGCAGGCTTGCAACCAGGACACCCCTGAGGAACGGTGCAGTGTGGCAGCCTACGTCAGTGCGAGGACCATGCCTGAAGCCAAGGCTGATGACAT TGTTGGCCCTGTGACGCATGAAATCTTTGAGAACAACGTCGTCCACTTGATGTGGCAGGAGCCGAAGGAGCCCAATGGTCTGATCGTGCTGTATGAAGTG AGTTATCGGCGATATGGTGATGAGGAGCTGCATCTCTGCGTCTCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGA ACTACAGCGTGCGAATCCGGGCCACCTCCCTTGCGGGCAACGGCTCTTGGACGGAACCCACCTATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAA TATTGCAAAAATTATCATCGGCCCCCTCATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGG CCGCTGGGACCGCTTTACGCTTCTTCAAACCCTGAGTATCTCAGTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTC GAGAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGGCAGAGACCCG CGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTCTCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGGGCTTCACCTGCCATCACGTG GTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACGGAGACCTGAAGAGCTACCTCCGTTCTCTGCGGC CAGAGGCTGAGAATAATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGGCGGCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAA GAAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCCATGATTTTACTGTCAAAATTGGAGACTTTGGAATGACCAGAGACATCTATGAA ACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTGTACGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGT GGTCCTTTGGCGTGGTCCTTTGGGAAATCACCAGCTTGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGG GTATCTGGATCAACCCGACAACTGTCCAGAGAGAGTCACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATT GTCAACCTGCTCAAGGACGACCTGCACCCCAGCTTTCCAGAGGTGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGG AGTTTGAGGACATGGAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGGGTTTCAAGCG GAGCTACGAGGAACACATCCCTTACACACACATGAACGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCAATCCTTCCTAACAGTGCCTA CCGTGGCGGGGGCGGGCAGGGGTTCCCATTTTCGCTTTCCTCTGGTTTGAAAGCCTCTGGAAAACTCAGGATTCTCACGACTCTACCATGTCCAATGGAG TTCAGAGATCGTTCCTATACATTTCTGTTCATCTTAAGGTGGACTCGTTTGGTTACCAATTTAACTAGTCCTGCAGAGGATTTAACTGTGAACCTGGAGG GCAAGGGGTTTCCACAGTTGCTGCTCCTTTGGGGCAACGACGGTTTCAAACCAGGATTTTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAGCAGATGGAA AGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTTTTTTTTTTTTGCTGGTGTCTGAGCTTCAGTATAAAAGACAAAACTTCCTGTTTGTGGAACAAAA GTTCGAAAGAAAAAACAAAACAAAAACACCCAGCCCTGTTCCAGGAGAATTTCAAGTTTTACAGGTTGAGCTTCAAGATGGTTTTTTTGGTTTTTTTTTT TTCTCTCATCCAGGCTGAAGGATTTTTTTTTTCTTTACAAAATGAGTTCCTCAAATTGACCAATAGCTGCTGCTTTCATATTTTGGATAAGGGTCTGTGG TCCCGGCGTGTGCTCACGTGTGTATGCACGTGTGTGTGTCCATTAGACACGGCTGATGTGTGTGCAAAGTATCCATGCGGAGTTGATGCTTTGGGAATTG GCTCATGAAGGTTCTTCTCAAGGGTGCGAGCTCATCCCCCTCTCTCCTTCCTTCTTATTGACTGGGAGACTGTGCTCTCGACAGATTCTTCTTGTGTCAG AAGTCTAGCCTCAGGTTTCTACCCTCCCTTCACATTGGTGGCCAAGGGAGGAGCATTTCATTTGGAGTGATTATGAATCTTTTCAAGACCAAACCAAGCT AGGACATTAAAAAAAAAAAAAGAAAAAGAAAGAAAAAACAAAATGGAAAAAGGAAAAAAAAAAAGAACTGAGATGACAGAGTTTTGAGAATATATTTGTA CCATATTTAATTTTTAAAGTCTCTGGTATTAGCCTCATAAGTTATTGACTATTCCCCGGGGTTGGCGGGGAGTGGGGACATGAGTTGGTCTGCCTGTTGT GGGGCCGGGAAGGGGAGGGAGTCAGGCACAAGTGGCCTCTTTGTTTGGTCTTAAAGGCATCCATTTCTGGGAATGAAGCCATGTTCGCTGCTAACACTTT TGGATGTTGTGAGGCCACGTGGAGTGTGTGAGAGACTAGGTTTTATGGATGGTCTGGTTCAGGTACCAGGTCTGCTGGAAGGTTCCTGTTCGGATAAGCT GGTAGCTACCTAGCTCTGAGCCTGCCTTCAAGAACACCTGTGTTCATCCTCTGATTCTCTGTGTGTACCTCTTGTGGCGTTTCCTCTCCCGGGTGTGAAC ATCCTAACCGTTATTGTGCAAACCCAAGAACGTCAGATCCCAAAGCACAACAACCTGGATGGACTTTGGGAACATCTAAGCAATGTAAGAGAGAGGTGCA CTGAGAGTACGTCTTGGTCCCCTCCACCCTGAGAGCATCTGACGGTCCTCAGTACTGAACTCCCGGAAGCTGCTCTGAGCCCGGTGACCTCATCTGGGCC AGGTGTGGTGCCTGAGCTGAATGCTCAGGTGCTTACAGTGTTGCAATCCCTAAGAGAGTAGAGTCTGGAGGAGAAACCGTGAAAAAGACCTTACACACCA CCAAGAACTTCCGAATGGGCGTGAATCCACCGTTTCTTCTCTTTGCAAAAAGAACCACCACAGCTGCTCAAAGAACACAGTGAACTCATCACTTTGGTTC ATCAAAAAATCATCGCCCATGCGTTATTCCTGAGTGCATTTTCTTACAACTTTTTGACTGCTTCCTTTTCTTCTTCTCTTAAGAGTTGTGGGCTTAAGAA TGGGATAGAGTCATAATGGCAACCTCCAAGCCCTCTCAATTCTTGATTAAGAACACAGGTAGACATGAATCCCAATTGTCTATTGCTATCTTATTTATAT GATTCGGGAAAATACAGCATGTAAAAATATTGCTGAGGAGCCTCAGTGATTGGGTACAAGAAGCAAGAGTACAGAAATTATTTTTGCCAAATTTATTTTG TAAATATGAGGGTCTGTACCTAAATTTAAAAAAAAAACACGTAGAACTAGGTATTTTGTTCTCTTCTTAGTAAATTTGTAGTGGTTGTATACTACACTAG CTGCAATTTTCACATTTTTCTAATTCAGAAAGGTTTTTCTTATATTAGGGGAAAAAGTATTTATTTTAATATATAAAATCACTCTGAAAATCACTCTCAT AAAAAATGGAGCGCATGTAAATTTTTATCAAAGAAAAATAAACAGGTGAATGGGGGATAGTGATTTTCTTTTTTCAGCACAGTCTACCTCAGTGTATTGT TAAGATGTGATTCAATCATGGACATCTTTGAGATTTCAGAATTCTACCTGGAACCGGTCTGAATCAGGGAACGTGTGTATCAGCTGATTCGAATGCCAGG GACCAGTAAGAATTTTGAGGGAGGGAGTTGGGATGGAGAAGGTATGGCCTTTATGCGAGCATAGATCCTTTTCTTCCTGGCTGGTAATATTCTTCTCTGA ATTTAATCTTCCTTTAAAAAAAAATCCTCCATCTATTGTCACTATGTTCCCCAAACATAAACTAAGTTCCAGGCTGTCATGATGTATCTGATATATGGGG TAACCCAGCAAGGTGTACCTTCCTTTGGTGAGAGATGGCTGCCGGGGCAAAGACGGGCTTTGATTCAGAGCAAGCATTCCCACCTGTTCCATGGAATCCC CCTGAAGTGAGCACAAAGGTGCCCTGGGCTCCCTGATGGTTTATGCCCACTCCTTTCAGGCTGGTGATGCACCTTACACACAAACACCTAATGCAATGTC TTTTTAAATTCTCCAAGTGGGATGGGAGCATGTGAGGGAAATTCCAATCCAAAACCCATTAATGTGCTGAACGCTTTTTTTTTTTTTTTTTTTTTTTTTG CAACAACACCTTGGACCTCTGTGTTGGGGTTTGACTGACCTCAAGCTGATATTATTGGACCTTGTGCAGCTTTGATAACCCATGTGAGAGTCTAGGCAGG ACCAGTGGGGCCCAAATCTTGCTGCTCTTGTACTTTTAGGCACTGCCCTTGCAGACTCACCTTTCTCCACCTGCCCTGGAGAAAGGTAGGGTGTGCTGGG CCTGCCCCTTGCAAATGGGATTCACCAGTTTCATTTATTTGACTCTACTGCCACAGTGAAAAGAGCAAACAGCTATTGGGTTGCAAACCTCCTTTGACAT TAGGAAATGTTGACTTTGTAACAATAAAACTTTGGTCCTAGAAAGACACGGTTGTCCTGGGAGTTTGTAGTGTTAAGTTGCAACAACAACAACAAAAAGC AACAAAACCAGCTTAGGATAACACTTTTTGTTGCTTGTTCTTAAAGATGTCTCACTATGATTAAAACCCTTTTCATTAATGTAGTGAAAGCCACACAGGA GTTCCTTCTTCCAGGAGGAGAATACCAAGCACATCACTTTCTCTCTGCATCAGTGATGTCAAATACGCATCAGAAAATGTTCAGGTTTTAGGAGCTGTCC TAGGTGCTGTTTCATCATTGGAAGCAGTGAGAAAGAGAAGCACTGCTGCTTGTCTGGATATAGGCTGAGGATGATTGAGAGAAGCTGTGGGAACTGACAC AAGGGTCTGCATAGGTCATCCTGTGACCCTGGGGACTATGTTACCAACTGACAGACAGATCTTTCACTGTATCCTAGCAGGGCAGGTAGTCCACCAAGAA ATGTGCTTATTGGATTGGGAGGTGTTTATTTGTAGTCTGCTGTAACACGTGTGAAAGAGCAGGAGCGTCATCAGCATATGACTTGCGCTGGTCATCCGGT AAATGGATGTGCTGTAGTCCCAGTGCTAATCATTTCTCTCCTTCACAGTGGGTGGAAGTTTAGGGTTAAATGTCCTTTGAATGTCACCTGGTGAGTCCTT GACACCTTAGGCTCTTCAGAAACAATGGTTTTGTTGAGGATGGGGAACAGGGAATGCCGATTTTATATACATGGTACACAGAGAGGGGTGTCACTTCAGA AAATCTTCCAGCATGTTCTTCAGAATATTAATTTATATGCGAGGTGAGGTTGGGAATGAAAAGAACAGGTCAGCACTTTTTTTTTTCCTAGAACATACAA AAGAACATGGTGGACTTTCAGGGAGTGCAATGGAAGGTGAATATTTCCTTAAGGGTCCCCGAGAAATGGGAGTGAGGGGAGGGGACACAATGGCTTTTTG AGCTTACTTTTACCTTCTGATACTAGTCAAGGTCCAGAACCAGCCACCAGCCAAATTTCTATCTGGGTGCGGGCCACTGAAAATCCTTGTTAAAAACCAG ATCACAAATCTGGGGCTCTTGGTCCCATTGGAGAAGGAAGGAAGAGCCTCAAAATAAGTGTGCACCCATGCACATATTCAGGAACAGCTTGTTTAGTCTT TACACTTTGCCTGAAAGTTGCTTCTCCTCGTCCCTTTGTGTGCCTGGGTGGCCTCGGCCCTGTGCGTTGGCAACGCAGGATCAAATGTGCTGCAGCTTTT GCAGAAAACAACTCAGAAACACAAAACCCCCCAACAGCTCAATTATTATTTTTTCAATGTTTTCCTACAAGAGCCAAGTAGCACCATGTACAGAAGACGC CTTTTTTTTTGGAATATTGAAATCGTTCTGCATGTAAAATATGGGATAATGACCTGTTTATATTAAAATTCTGATTAAATTATCTGAGAATA

INSR.u.f.15 (forward primer)
INSR.u.r.18 (reverse primer)
Single exon skipping

Frame 0

SRRPPATRQPRCPPASQLVRRSARPSVPEPADR DPERAGPRAERQSRAQRGAPGPEILGRGPGRSGR GVGATTARASAQYL*LAKPRAPFPGLPLGPPRQ GGCGPRVAGVEEKDARPPAPLGWPPRSMTPAGQ RRAL*SEETPRSRSHGHRGPAGGGGRAAAGGGGR AATGRRGPPVPRRGVSRHGYPEQPH*VA*AGEL LCHRRTLADTLDVQNEARRFPRPQFPQTHHDH* LLAALPGLWAREPEGPVPQPHGHPGITTVL*LRA GHLRDGSPQGTRPLQPDEHHPGFCPHREEQ*AL LLGHYRLVPYPGFRGG*LHRVEQR*QRGVWRHL SGYREGQDQLPRHRHQRAVCRTMLDS*SLPESLP DHL*VTRLHRRRPLLPQRVPGQLFSARRPHQVR GLPQLLPGRQVCGDLPAPVLPLPGLALCELQLL PGPAPQMQELAEAGLPPVRHSQQQVHP*VSLRVH DEFQQLAVHPMPGSLSQGVPPPRRREDHRLGDV CPGAPRMHRHQRESDHQHSRRQQSGS*ARSQPR PH*RNFRVSKNPPILRSGVTFLLPEVTSDSRRDL GNWELLLLCLGQPEPKAALGLEQTQPHHHSGET LLPL*PQTLLVRNPQDGRSFRNQGAPGEKRHCP EDQWGPGIL*K*VT*IFLHSDIF*QDLAEMGAVL APRLPRPLGVHAVLQRGPLSECDGVRRAGCVWF QQLDGGRH*PTPEVQRPQITEPPRVADAGSQAL DPVCHLCEDPGHLFG*TPDLWGQE*HHLCPDRCH QPLCAPGSNLSV*LIIPDYSEVETTLRPQWQHH PLPGFLGEAGGRQ*AVRAGLLPQRAEAALEDLV STIRV*RFSEAQPE*V*GFGRRMLLLSKDRLSDP EGAGGVLV*EDV*GLPAQRGFRPQKNLFRHWCR GP*AISETQVPWRCWECDGGRAHGGSFPQHFLD QRAHESGGAQAF*EGGEQGVAGHLRLATLHGLSH RAAGLQPGHP*GTVQCGSLRQCEDHA*SQG**H CWPCDA*NL*EQRRPLDVAGAEGAQWSDRAV*S ELSAIW**GAASLRLPQALRSGTGLQAAWAVTGE LQRANPGHLPCGQRLLDGTHLFLRDRLFRRPVK YCKNYHRPPHLCLSLQCCDWKYLSIPEKEAARW AAGTALRFFKP*VSQCQ*CVSMLCVRAGRVGGVS REDHPPSRAGAGLLRHGV*GQCQGHHQG*GRDP RGGEDGQRVSQSPRAD*VPQ*GLGHEGLHLPSR GAPPGSGVQGPAHAGGDGADGSRRPEELPPFSAA RG*E*SWPPSPYPSRDDSDGGRDC*RDGLPERQ EVCASGPGSEKLHGRP*FYCQNWRLWNDQRHL* NGLLPERGQGSAPCTVDGTGVPEGWGLHHFF*HV VLWRGPLGNHQLGRTALPRPV**TGVEICHGWR VSGSTRQLSRESH*PHAHVLAIQPQDEANLPGD CQPAQGRPAPQLSRGVVLPQRGEQGSRE*GAGDG V*GHGECAPGPFLALSEGGGGGPGWRVLAGFQA ELRGTHPLHTHERRQEKRADSDLASVQSFLTVP TVAGAGRGSHFRFPLV*KPLENSGFSRLYHVQWS SEIVPIHFCSS*GGLVWLPI*LVLQRI*L*TWR ARGFHSCCSFGATTVSNQDFVFFRSPHPPPADG KKAPVFTNSFFFFFFLLVSELQYKRQNFLFVEQK FERKNKTKTPSPVPGEFQVLQVELQDGFFGFFF FSHPG*RIFFFFTK*VPQIDQ*LLLSYFG*GSV VPACAHVCMHVCVSIRHG*CVCKVSMRS*CFGNW LMKVLLKGASSSPSLLPSY*LGDCALDRFFLCQ KSSLRFLPSLHIGGQGRSISFGVIMNLFKTKPS *DIKKKKRKRKKKQNGKRKKKKN*DDRVLRIYLY HI*FLKSLVLAS*VIDYSPGLAGSGDMSWSACC GAGKGRESGTSGLFVWS*RHPFLGMKPCSLLTL LDVVRPRGVCERLGFMDGLVQVPGLLEGSCSDKL VAT*L*ACLQEHLCSSSDSLCVPLVAFPLPGVN ILTVIVQTQERQIPKHNNLDGLWEHLSNVRERC TESTSWSPPP*EHLTVLSTELPEAALSPVTSSGP GVVPELNAQVLTVLQSLRE*SLEEKP*KRPYTP PRTSEWA*IHRFFSLQKEPPQLLKEHSELITLV HQKIIAHALFLSAFSYNFLTASFSSSLKSCGLKN GIES*WQPPSPLNS*LRTQVDMNPNCLLLSYLY DSGKYSM*KYC*GASVIGYKKQEYRNYFCQIYF VNMRVCT*I*KKNT*N*VFCSLLSKFVVVVYYTS CNFHIFLIQKGFSYIRGKSIYFNI*NHSENHSH KKWSACKFLSKKNKQVNGG**FSFFSTVYLSVL LRCDSIMDIFEISEFYLEPV*IRERVYQLIRMPG TSKNFEGGSWDGEGMAFMRA*ILFFLAGNILL* I*SSFKKKSSIYCHYVPQT*TKFQAVMMYLIYG VTQQGVPSFGERWLPGQRRALIQSKHSHLFHGIP LK*AQRCPGLPDGLCPLLSGW*CTLHTNT*CNV FLNSPSGMGACEGNSNPKPINVLNAFFFFFFFF ATTPWTSVLGFD*PQADIIGPCAALITHVRV*AG PVGPKSCCSCTFRHCPCRLTFLHLPWRKVGCAG PAPCKWDSPVSFI*LYCHSEKSKQLLGCKPPLT LGNVDFVTIKLWS*KDTVVLGVCSVKLQQQQQKA TKPA*DNTFCCLFLKMSHYD*NPFH*CSESHTG VPSSRRRIPSTSLSLCISDVKYASENVQVLGAV LGAVSSLEAVRKRSTAACLDIG*G*LREAVGTDT RVCIGHPVTLGTMLPTDRQIFHCILAGQVVHQE MCLLDWEVFICSLL*HV*KSRSVISI*LALVIR *MDVL*SQC*SFLSFTVGGSLGLNVL*MSPGESL TP*ALQKQWFC*GWGTGNADFIYMVHREGCHFR KSSSMFFRILIYMRGEVGNEKNRSALFFFLEHT KEHGGLSGSAMEGEYFLKGPREMGVRGGDTMAF* AYFYLLILVKVQNQPPAKFLSGCGPLKILVKNQ ITNLGLLVPLEKEGRASK*VCTHAHIQEQLV*S LHFA*KLLLLVPLCAWVASALCVGNAGSNVLQLL QKTTQKHKTPQQLNYYFFNVFLQEPSSTMYRRR LFFWNIEIVLHVKYGIMTCLY*NSD*II*E

Frame 1

PAARPPPASPGARPPVS*SVGPRVPLSRSPQIA TQSARGREPRDSPGRSAELRAPRSWDGARAAAA GGSGPPPQGPPLSICSWRSRARPSRGCLWALPGR GAAARGSRAWKRRTRGPQRLLGGRLGA*PPRAS AARSDPRRPRAPAAMATGGRRGAAAAPLLVAVA ALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENC SVIEGHLQILLMFKTRPEDFRDLSFPKLIMITD YLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYA LVIFEMVHLKELGLYNLMNITRGSVRIEKNNELC YLATIDWSRILDSVEDNYIVLNKDDNEECGDIC PGTAKGKTNCPATVINGQFVERCWTHSHCQKVC PTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCV ACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFC QDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGY TMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTS AQELRGCTVINGSLIINIRGGNNLAAELEANLG LIEEISGYLKIRRSYALVSLSFFRKLRLIRGET LEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKL FFHYNPKLCLSEIHKMEEVSGTKGRQERNDIAL KTNGDQASCENELLKFSYIRTSFDKILLRWEPY WPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGS NSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPW TQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDA TNPSVPLDPISVSNSSSQIILKWKPPSDPNGNIT HYLVFWERQAEDSELFELDYCLKGLKLPSRTWS PPFESEDSQKHNQSEYEDSAGECCSCPKTDSQI LKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAE DPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSST SVPTSPEEHRPFEKVVNKESLVISGLRHFTGYR IELQACNQDTPEERCSVAAYVSARTMPEAKADDI VGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEV SYRRYGDEELHLCVSRKHFALERGCRLRGLSPG NYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSN IAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDG PLGPLYASSNPEYLSASDVFPCSVYVPDEWEVS REKITLLRELGQGSFGMVYEGNARDIIKGEAETR VAVKTVNESASLRERIEFLNEASVMKGFTCHHV VRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLR PEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAK KFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE TDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDM WSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGG YLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEI VNLLKDDLHPSFPEVSFFHSEENKAPESEELEM EFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKR SYEEHIPYTHMNGGKKNGRILTLPRSNPS*QCL PWRGRAGVPIFAFLWFESLWKTQDSHDSTMSNG VQRSFLYISVHLKVDSFGYQFN*SCRGFNCEPGG QGVSTVAAPLGQRRFQTRILCFFVPPTRPQQME RKHLFLQILFFFFFFCWCLSFSIKDKTSCLWNK SSKEKTKQKHPALFQENFKFYRLSFKMVFLVFFF SLIQAEGFFFSLQNEFLKLTNSCCFHILDKGLW SRRVLTCVCTCVCPLDTADVCAKYPCGVDALGI GS*RFFSRVRAHPPLSFLLIDWETVLSTDSSCVR SLASGFYPPFTLVAKGGAFHLE*L*IFSRPNQA RTLKKKKEKERKNKMEKGKKKRTEMTEF*EYIC TIFNF*SLWY*PHKLLTIPRGWRGVGT*VGLPVV GPGRGGSQAQVASLFGLKGIHFWE*SHVRC*HF WML*GHVECVRD*VLWMVWFRYQVCWKVPVRIS W*LPSSEPAFKNTCVHPLILCVYLLWRFLSRV*T S*PLLCKPKNVRSQSTTTWMDFGNI*AM*ERGA LRVRLGPLHPESI*RSSVLNSRKLL*AR*PHLG QVWCLS*MLRCLQCCNP*ESRVWRRNREKDLTHH QELPNGRESTVSSLCKKNHHSCSKNTVNSSLWF IKKSSPMRYS*VHFLTTF*LLPFLLLLRVVGLR MG*SHNGNLQALSILD*EHR*T*IPIVYCYLIYM IRENTACKNIAEEPQ*LGTRSKSTEIIFAKFIL *I*GSVPKFKKKTRRTRYFVLFLVNL*WLYTTL AAIFTFF*FRKVFLILGEKVFILIYKITLKITLI KNGAHVNFYQRKINR*MGDSDFLFSAQSTSVYC *DVIQSWTSLRFQNSTWNRSESGNVCIS*FECQ GPVRILREGVGMEKVWPLCEHRSFSSWLVIFFSE FNLPLKKNPPSIVTMFPKHKLSSRLS*CI*YMG *PSKVYLPLVRDGCRGKDGL*FRASIPTCSMES P*SEHKGALGSLMVYAHSFQAGDAPYTQTPNAMS F*ILQVGWEHVREIPIQNPLMC*TLFFFFFFFL QQHLGPLCWGLTDLKLILLDLVQL**PM*ESRQ DQWGPNLAALVLLGTALADSPFSTCPGER*GVLG LPLANGIHQFHLFDSTATVKRANSYWVANLL*H *EMLTL*Q*NFGPRKTRLSWEFVVLSCNNNNKK QQNQLRITLFVACS*RCLTMIKTLFINVVKATQE FLLPGGEYQAHHFLSASVMSNTHQKMFRF*ELS *VLFHHWKQ*EREALLLVWI*AEDD*EKLWELT QGSA*VIL*PWGLCYQLTDRSFTVS*QGR*STKK CAYWIGRCLFVVCCNTCERAGASSAYDLRWSSG KWMCCSPSANHFSPSQWVEV*G*MSFECHLVSP *HLRLFRNNGFVEDGEQGMPILYTWYTERGVTSE NLPACSSEY*FICEVRLGMKRTGQHFFFS*NIQ KNMVDFQGVQWKVNISLRVPEKWE*GEGTQWLF ELTFTF*Y*SRSRTSHQPNFYLGAGH*KSLLKTR SQIWGSWSHWRRKEEPQNKCAPMHIFRNSLFSL YTLPESCFSSSLCVPGWPRPCALATQDQMCCSF CRKQLRNTKPPNSSIIIFSMFSYKSQVAPCTEDA FFFGILKSFCM*NMG**PVYIKILIKLSEN

Frame 2

PPPARHPPAQVPARQSASPSVRASLCPGARRSR PRARGAESRETVPGAARSSGPRDPGTGPGPQRP GGRGHHRKGLRSVFVAGEAARALPGAASGPSPA GGLRPAGRGRGREGRAAPSASWVAASEHDPRGPA PRALIRGDPALPQPWPPGAGGGRRPRRCWWRWP RCYWAPRATCTPERCVPAWISGTTSLGCMSWRI ALSSKDTCRYS*CSKRGPKISETSVSPNSS*SLI TCCSSGSMGSRA*RTCSPTSRSSGDHDCSLTTR WSSSRWFTSRNSASTT**TSPGVLSASRRTMSS VTWPLSTGPVSWIPWRIITSC*TKMTTRSVETSV RVPRRARPTAPPPSSTGSLSNDVGLIVTARKFA RPSVSHTAAPPKASVATASAWATVLSPTTPPSA WPAATSTWTAGVWRPARPRTTTSRTGAV*TSASA RTCTTNARTRGGRAATSTSFTTTSASLSVPPGT R*IPATCCAPHAWVPVPRCATS*KARRPSTR*R LPRSSEDAPSSTGV*SSTFEEATIWQLS*KPTSA SLKKFQGI*KSADPTLWCHFPSSGSYV*FEERP WKLGTTPSMPWTTRT*GSSGTGANTTSPSLRGN SSSTITPNSACQKSTRWKKFQEPRGARRETTLP* RPMGTRHPVKMSYLNFLTFGHLLTRSC*DGSRT GPPTSETSWGSCCSTKRPLIRM*RSSTGRMRVV PTVGRW*TLTHP*GPTTPNHRTTQGG*CGVSSPG PSMPSL*RPWSPFRMNAGPMGPRVTSFMSRQMP PTPLCPWIQSQCLTHHPRLF*SGNHPPTPMATS PTTWFSGRGRRKTVSCSSWIIASKG*SCPRGPGL HHSSLKILRSTTRVSMRIRPANAAPVQRQTLRS *RSWRSPRLGRRLRITCTTWFSSPEKPLQALVP RTLGHLGNAGPLAMLGM*RWPCPRWQLSPTLPRP ACPRVRRSTGLLRRW*TRSRWSSPACDTSRAIA SSCRLATRTPLRNGAVWQPTSVRGPCLKPRLMT LLAL*RMKSLRTTSST*CGRSRRSPMV*SCCMK* VIGDMVMRSCISASPASTSLWNGAAGCVGCHRG TTACESGPPPLRATALGRNPPIST*QTI*TSRQ ILQKLSSAPSSLSFSSVL*LEVFIYS*ERGSQMG RWDRFTLLQTLSISVPVMCFHALCTCRTSGRCL ERRSPSFESWGRAPSAWCMRAMPGTSSRVRQRP AWR*RRSTSQPVSESGLSSSMRPRS*RASPAITW CASWEWCPRASPRWW*WS*WLTET*RATSVLCG QRLRIILAALPLPFKR*FRWRQRLLTGWPT*TP RSLCIGTWQRETAWSPMILLSKLETLE*PETSMK RITTGKGARVCSLYGGWHRSP*RMGSSPLLLTC GPLAWSFGKSPAWQNSLTKACLMNRC*NLSWME GIWINPTTVQRESLTSCACAGNSTPR*GQPSWRL STCSRTTCTPAFQRCRSSTARRTRLPRVRSWRW SLRTWRMCPWTVPRTVRGRRRGAGMEGPRWVSS GATRNTSLTHT*TEARKTGGF*PCLGPILPNSAY RGGGGQGFPFSLSSGLKASGKLRILTTLPCPME FRDRSYTFLFILRWTRLVTNLTSPAEDLTVNLE GKGFPQLLLLWGNDGFKPGFCVFSFPPPAPSRWK ESTCFYKFFFFFFFFAGV*ASV*KTKLPVCGTK VRKKKQNKNTQPCSRRISSFTG*ASRWFFWFFF FLSSRLKDFFFLYKMSSSN*PIAAAFIFWIRVCG PGVCSRVYARVCVH*TRLMCVQSIHAELMLWEL AHEGSSQGCELIPLSPSFLLTGRLCSRQILLVS EV*PQVSTLPSHWWPREEHFIWSDYESFQDQTKL GH*KKKKKKKEKTKWKKEKKKELR*QSFENIFV PYLIFKVSGISLISY*LFPGVGGEWGHELVCLL WGREGEGVRHKWPLCLVLKASISGNEAMFAANTF GCCEATWSV*ETRFYGWSGSGTRSAGRFLFG*A GSYLALSLPSRTPVFIL*FSVCTSCGVSSPGCE HPNRYCANPRTSDPKAQQPGWTLGTSKQCKREVH *EYVLVPSTLRASDGPQY*TPGSCSEPGDLIWA RCGA*AECSGAYSVAIPKRVESGGETVKKTLHT TKNFRMGVNPPFLLFAKRTTTAAQRTQ*THHFGS SKNHRPCVIPECIFLQLFDCFLFFFS*ELWA*E WDRVIMATSKPSQFLIKNTGRHESQLSIAILFI *FGKIQHVKILLRSLSDWVQEARVQKLFLPNLFC KYEGLYLNLKKKHVELGILFSS**ICSGCILH* LQFSHFSNSERFFLY*GKKYLF*YIKSL*KSLS *KMERM*IFIKEK*TGEWGIVIFFFQHSLPQCIV KM*FNHGHL*DFRILPGTGLNQGTCVSADSNAR DQ*EF*GRELGWRRYGLYASIDPFLPGW*YSSL NLIFL*KKILHLLSLCSPNIN*VPGCHDVSDIWG NPARCTFLW*EMAAGAKTGFDSEQAFPPVPWNP PEVSTKVPWAP*WFMPTPFRLVMHLTHKHLMQC LFKFSKWDGSM*GKFQSKTH*CAERFFFFFFFFC NNTLDLCVGV*LTSS*YYWTLCSFDNPCESLGR TSGAQILLLLYF*ALPLQTHLSPPALEKGRVCW ACPLQMGFTSFIYLTLLPQ*KEQTAIGLQTSFDI RKC*LCNNKTLVLERHGCPGSL*C*VATTTTKS NKTSLG*HFLLLVLKDVSL*LKPFSLM**KPHR SSFFQEENTKHITFSLHQ*CQIRIRKCSGFRSCP RCCFIIGSSEKEKHCCLSGYRLRMIERSCGN*H KGLHRSSCDPGDYVTN*QTDLSLYPSRAGSPPR NVLIGLGGVYL*SAVTRVKEQERHQHMTCAGHPV NGCAVVPVLIISLLHSGWKFRVKCPLNVTW*VL DTLGSSETMVLLRMGNRECRFYIHGTQRGVSLQ KIFQHVLQNINLYAR*GWE*KEQVSTFFFPRTYK RTWWTFRECNGR*IFP*GSPRNGSEGRGHNGFL SLLLPSDTSQGPEPATSQISIWVRATENPC*KP DHKSGALGPIGEGRKSLKISVHPCTYSGTACLVF TLCLKVASPRPFVCLGGLGPVRWQRRIKCAAAF AENNSETQNPPTAQLLFFQCFPTRAK*HHVQKT PFFLEY*NRSACKIWDNDLFILKF*LNYLRI