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Sequences

Sequence ADAM15.cAug05

CTGGGGTGAGCCGCGCACTGCCTCGCCTGCAGTCGGGAAAGCCTGCCCGCCCGACCTCTCCGAGCCAGGCCGCGCACAGGAGGCAGGGAGGCCGCGAAGC TACTAGGGAGGGGTCCGGACCTGGCGCCGGGTGAAGGCGCGCCGCCCAAGCCGGTCGGACCGGGCACCGGCTCCCACTCCGCACAGTTGCGGGGAAGCGG TAGCGCTGAGCAGCGCGGGCGTAGTGGGCGGTGTCCCCGCTCCCGAGGCACCCGGCGCGCAGCGGGGCGGGCTTTGCCGGGGGCGGAGCTTGGCTTGGGG CCGGGTGGGAGGGGGCGGGCCGGGGCGGGGCCTGGTGGCCGCGCGGCGCTGCTGGGTTCTCCGAGGCGACCTGGCCGCCGGCCGCTCCTCCGCGCGCTGT TCCGCACTTGCTGCCCTCGCCCGGCCCGGAGCGCCGCTGCCATGCGGCTGGCGCTGCTCTGGGCCCTGGGGCTCCTGGGCGCGGGCAGCCCTCTGCCTTC CTGGCCGCTCCCAAATATAGGTGGCACTGAGGAGCAGCAGGCAGAGTCAGAGAAGGCCCCGAGGGAGCCCTTGGAGCCCCAGGTCCTTCAGGACGATCTC CCAATTAGCCTCAAAAAGGTGCTTCAGACCAGTCTGCCTGAGCCCCTGAGGATCAAGTTGGAGCTGGACGGTGACAGTCATATCCTGGAGCTGCTACAGA ATAGGGAGTTGGTCCCAGGCCGCCCAACCCTGGTGTGGTACCAGCCCGATGGCACTCGGGTGGTCAGTGAGGGACACACTTTGGAGAACTGCTGCTACCA GGGAAGAGTGCGGGGATATGCAGGCTCCTGGGTGTCCATCTGCACCTGCTCTGGGCTCAGAGGCTTGGTGGTCCTGACCCCAGAGAGAAGCTATACCCTG GAGCAGGGGCCTGGGGACCTTCAGGGTCCTCCCATTATTTCGCGAATCCAAGATCTCCACCTGCCAGGCCACACCTGTGCCCTGAGCTGGCGGGAATCTG TACACACTCAGAAGCCACCAGAGCACCCCCTGGGACAGCGCCACATTCGCCGGAGGCGGGATGTGGTAACAGAGACCAAGACTGTGGAGTTGGTGATTGT GGCTGATCACTCGGAGGCCCAGAAATACCGGGACTTCCAGCACCTGCTAAACCGCACACTGGAAGTGGCCCTCTTGCTGGACACATTCTTCCGGCCCCTG AATGTACGAGTGGCACTAGTGGGCCTGGAGGCCTGGACCCAGCGTGACCTGGTGGAGATCAGCCCAAACCCAGCTGTCACCCTCGAAAACTTCCTCCACT GGCGCAGGGCACATTTGCTGCCTCGATTGCCCCATGACAGTGCCCAGCTGGTGACTGGTACTTCATTCTCTGGGCCTACGGTGGGCATGGCCATTCAGAA CTCCATCTGTTCTCCTGACTTCTCAGGAGGTGTGAACATGGACCACTCCACCAGCATCCTGGGAGTCGCCTCCTCCATAGCCCATGAGTTGGGCCACAGC CTGGGCCTGGACCATGATTTGCCTGGGAATAGCTGCCCCTGTCCAGGTCCAGCCCCAGCCAAGACCTGCATCATGGAGGCCTCCACAGACTTCCTACCAG GCCTGAACTTCAGCAACTGCAGCCGACGGGCCCTGGAGAAAGCCCTCCTGGATGGAATGGGCAGCTGCCTCTTCGAACGGCTGCCTAGCCTACCCCCTAT GGCTGCTTTCTGCGGAAATATGTTTGTGGAGCCGGGCGAGCAGTGTGACTGTGGCTTCCTGGATGACTGCGTCGATCCCTGCTGTGATTCTTTGACCTGC CAGCTGAGGCCAGGTGCACAGTGTGCATCTGACGGACCCTGTTGTCAAAATTGCCAGCTGCGCCCGTCTGGCTGGCAGTGTCGTCCTACCAGAGGGGATT GTGACTTGCCTGAATTCTGCCCAGGAGACAGCTCCCAGTGTCCCCCTGATGTCAGCCTAGGGGATGGCGAGCCCTGCGCTGGCGGGCAAGCTGTGTGCAT GCACGGGCGTTGTGCCTCCTATGCCCAGCAGTGCCAGTCACTTTGGGGACCTGGAGCCCAGCCCGCTGCGCCACTTTGCCTCCAGACAGCTAATACTCGG GGAAATGCTTTTGGGAGCTGTGGGCGCAACCCCAGTGGCAGTTATGTGTCCTGCACCCCTAGAGATGCCATTTGTGGGCAGCTCCAGTGCCAGACAGGTA GGACCCAGCCTCTGCTGGGCTCCATCCGGGATCTACTCTGGGAGACAATAGATGTGAATGGGACTGAGCTGAACTGCAGCTGGGTGCACCTGGACCTGGG CAGTGATGTGGCCCAGCCCCTCCTGACTCTGCCTGGCACAGCCTGTGGCCCTGGCCTGGTGTGTATAGACCATCGATGCCAGCGTGTGGATCTCCTGGGG GCACAGGAATGTCGAAGCAAATGCCATGGACATGGGGTCTGTGACAGCAACAGGCACTGCTACTGTGAGGAGGGCTGGGCACCCCCTGACTGCACCACTC AGCTCAAAGCAACCAGCTCCCTGACCACAGGGCTGCTCCTCAGCCTCCTGGTCTTATTGGTCCTGGTGATGCTTGGTGCCAGCTACTGGTACCGTGCCCG CCTGCACCAGCGACTCTGCCAGCTCAAGGGACCCACCTGCCAGTACAGGGCAGCCCAATCTGGTCCCTCTGAACGGCCAGGACCTCCGCAGAGGGCCCTG CTGGCACGAGGCACTAAGCAGGCTAGTGCTCTCAGCTTCCCGGCCCCCCCTTCCAGGCCGCTGCCGCCTGACCCTGTGTCCAAGAGACTCCAGTCTCAGG GGCCAGCCAAGCCCCCACCCCCAAGGAAGCCACTGCCTGCCGACCCCCAGGGCCGGTGCCCATCGGGTGACCTGCCCGGCCCAGGGGCTGGAATCCCGCC CCTAGTGGTACCCTCCAGACCAGCGCCACCGCCTCCGACAGTGTCCTCGCTCTACCTCTGACCTCTCCGGAGGTTCCGCTGCCTCCAAGCCGGACTTAGG GCTTCAAGAGGCGGGCGTGCCCTCTGGAGTCCCCTACCATGACTGAAGGCGCCAGAGACTGGCGGTGTCTTAAGACTCCGGGCACCGCCACGCGCTGTCA AGCAACACTCTGCGGACCTGCCGGCGTAGTTGCAGCGGGGGCTTGGGGAGGGGCTGGGGGTTGGACGGGATTGAGGAAGGTCCGCACAGCCTGTCTCTGC TCAGTTGCAATAAACGTGACATCTTGGGAGCGTTCCCCAGA

ADAM15.F7 (forward primer)
ADAM15.R2 (reverse primer)
Single exon skipping

Frame 0

LG*AAHCLACSRESLPARPLRARPRTGGREAAK LLGRGPDLAPGEGAPPKPVGPGTGSHSAQLRGSG SAEQRGRSGRCPRSRGTRRAAGRALPGAELGLG PGGRGRAGAGPGGRAALLGSPRRPGRRPLLRAL FRTCCPRPARSAAAMRLALLWALGLLGAGSPLPS WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDL PISLKKVLQTSLPEPLRIKLELDGDSHILELLQ NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTL EQGPGDLQGPPIISRIQDLHLPGHTCALSWRES VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIV ADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPL NVRVALVGLEAWTQRDLVEISPNPAVTLENFLH WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQN SICSPDFSGGVNMDHSTSILGVASSIAHELGHS LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLP GLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTC QLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCM HGRCASYAQQCQSLWGPGAQPAAPLCLQTANTR GNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTG RTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLG SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG AQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTT QLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRAL LARGTKQASALSFPAPPSRPLPPDPVSKRLQSQ GPAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPP LVVPSRPAPPPPTVSSLYL*PLRRFRCLQAGLR ASRGGRALWSPLP*LKAPETGGVLRLRAPPRAV KQHSADLPA*LQRGLGEGLGVGRD*GRSAQPVSA QLQ*T*HLGSVPQ

Frame 1

WGEPRTASPAVGKACPPDLSEPGRAQEAGRPRS Y*GGVRTWRRVKARRPSRSDRAPAPTPHSCGEA VALSSAGVVGGVPAPEAPGAQRGGLCRGRSLAWG RVGGGGPGRGLVAARRCWVLRGDLAAGRSSARC SALAALARPGAPLPCGWRCSGPWGSWARAALCL PGRSQI*VALRSSRQSQRRPRGSPWSPRSFRTIS QLASKRCFRPVCLSP*GSSWSWTVTVISWSCYR IGSWSQAAQPWCGTSPMALGWSVRDTLWRTAAT REECGDMQAPGCPSAPALGSEAWWS*PQREAIPW SRGLGTFRVLPLFRESKISTCQATPVP*AGGNL YTLRSHQSTPWDSATFAGGGMW*QRPRLWSW*L WLITRRPRNTGTSSTC*TAHWKWPSCWTHSSGP* MYEWH*WAWRPGPSVTWWRSAQTQLSPSKTSST GAGHICCLDCPMTVPSW*LVLHSLGLRWAWPFR TPSVLLTSQEV*TWTTPPASWESPPP*PMSWATA WAWTMICLGIAAPVQVQPQPRPASWRPPQTSYQ A*TSATAADGPWRKPSWMEWAAASSNGCLAYPL WLLSAEICLWSRASSVTVASWMTASIPAVIL*PA S*GQVHSVHLTDPVVKIASCARLAGSVVLPEGI VTCLNSAQETAPSVPLMSA*GMASPALAGKLCA CTGVVPPMPSSASHFGDLEPSPLRHFASRQLILG EMLLGAVGATPVAVMCPAPLEMPFVGSSSARQV GPSLCWAPSGIYSGRQ*M*MGLS*TAAGCTWTW AVMWPSPS*LCLAQPVALAWCV*TIDASVWISWG HRNVEANAMDMGSVTATGTATVRRAGHPLTAPL SSKQPAP*PQGCSSASWSYWSW*CLVPATGTVP ACTSDSASSRDPPASTGQPNLVPLNGQDLRRGPC WHEALSRLVLSASRPPLPGRCRLTLCPRDSSLR GQPSPHPQGSHCLPTPRAGAHRVTCPAQGLESR P*WYPPDQRHRLRQCPRSTSDLSGGSAASKPDLG LQEAGVPSGVPYHD*RRQRLAVS*DSGHRHALS SNTLRTCRRSCSGGLGRGWGLDGIEEGPHSLSL LSCNKRDILGAFPR

Frame 2

GVSRALPRLQSGKPARPTSPSQAAHRRQGGREA TREGSGPGAG*RRAAQAGRTGHRLPLRTVAGKR *R*AARA*WAVSPLPRHPARSGAGFAGGGAWLG AGWEGAGRGGAWWPRGAAGFSEATWPPAAPPRAV PHLLPSPGPERRCHAAGAALGPGAPGRGQPSAF LAAPKYRWH*GAAGRVREGPEGALGAPGPSGRS PN*PQKGASDQSA*APEDQVGAGR*QSYPGAATE *GVGPRPPNPGVVPARWHSGGQ*GTHFGELLLP GKSAGICRLLGVHLHLLWAQRLGGPDPREKLYP GAGAWGPSGSSHYFANPRSPPARPHLCPELAGIC THSEATRAPPGTAPHSPEAGCGNRDQDCGVGDC G*SLGGPEIPGLPAPAKPHTGSGPLAGHILPAP ECTSGTSGPGGLDPA*PGGDQPKPSCHPRKLPPL AQGTFAASIAP*QCPAGDWYFILWAYGGHGHSE LHLFS*LLRRCEHGPLHQHPGSRLLHSP*VGPQ PGPGP*FAWE*LPLSRSSPSQDLHHGGLHRLPTR PELQQLQPTGPGESPPGWNGQLPLRTAA*PTPY GCFLRKYVCGAGRAV*LWLPG*LRRSLL*FFDL PAEARCTVCI*RTLLSKLPAAPVWLAVSSYQRGL *LA*ILPRRQLPVSP*CQPRGWRALRWRASCVH ARALCLLCPAVPVTLGTWSPARCATLPPDS*YS GKCFWELWAQPQWQLCVLHP*RCHLWAAPVPDR* DPASAGLHPGSTLGDNRCEWD*AELQLGAPGPG Q*CGPAPPDSAWHSLWPWPGVYRPSMPACGSPG GTGMSKQMPWTWGL*QQQALLL*GGLGTP*LHHS AQSNQLPDHRAAPQPPGLIGPGDAWCQLLVPCP PAPATLPAQGTHLPVQGSPIWSL*TARTSAEGP AGTRH*AG*CSQLPGPPFQAAAA*PCVQETPVSG ASQAPTPKEATACRPPGPVPIG*PARPRGWNPA PSGTLQTSATASDSVLALPLTSPEVPLPPSRT* GFKRRACPLESPTMTEGARDWRCLKTPGTATRCQ ATLCGPAGVVAAGAWGGAGGWTGLRKVRTACLC SVAINVTSWERSP

Sequence ADAM15.jAug05

CTGGGGTGAGCCGCGCACTGCCTCGCCTGCAGTCGGGAAAGCCTGCCCGCCCGACCTCTCCGAGCCAGGCCGCGCACAGGAGGCAGGGAGGCCGCGAAGC TACTAGGGAGGGGTCCGGACCTGGCGCCGGGTGAAGGCGCGCCGCCCAAGCCGGTCGGACCGGGCACCGGCTCCCACTCCGCACAGTTGCGGGGAAGCGG TAGCGCTGAGCAGCGCGGGCGTAGTGGGCGGTGTCCCCGCTCCCGAGGCACCCGGCGCGCAGCGGGGCGGGCTTTGCCGGGGGCGGAGCTTGGCTTGGGG CCGGGTGGGAGGGGGCGGGCCGGGGCGGGGCCTGGTGGCCGCGCGGCGCTGCTGGGTTCTCCGAGGCGACCTGGCCGCCGGCCGCTCCTCCGCGCGCTGT TCCGCACTTGCTGCCCTCGCCCGGCCCGGAGCGCCGCTGCCATGCGGCTGGCGCTGCTCTGGGCCCTGGGGCTCCTGGGCGCGGGCAGCCCTCTGCCTTC CTGGCCGCTCCCAAATATAGGTGGCACTGAGGAGCAGCAGGCAGAGTCAGAGAAGGCCCCGAGGGAGCCCTTGGAGCCCCAGGTCCTTCAGGACGATCTC CCAATTAGCCTCAAAAAGGTGCTTCAGACCAGTCTGCCTGAGCCCCTGAGGATCAAGTTGGAGCTGGACGGTGACAGTCATATCCTGGAGCTGCTACAGA ATAGGGAGTTGGTCCCAGGCCGCCCAACCCTGGTGTGGTACCAGCCCGATGGCACTCGGGTGGTCAGTGAGGGACACACTTTGGAGAACTGCTGCTACCA GGGAAGAGTGCGGGGATATGCAGGCTCCTGGGTGTCCATCTGCACCTGCTCTGGGCTCAGAGGCTTGGTGGTCCTGACCCCAGAGAGAAGCTATACCCTG GAGCAGGGGCCTGGGGACCTTCAGGGTCCTCCCATTATTTCGCGAATCCAAGATCTCCACCTGCCAGGCCACACCTGTGCCCTGAGCTGGCGGGAATCTG TACACACTCAGAAGCCACCAGAGCACCCCCTGGGACAGCGCCACATTCGCCGGAGGCGGGATGTGGTAACAGAGACCAAGACTGTGGAGTTGGTGATTGT GGCTGATCACTCGGAGGCCCAGAAATACCGGGACTTCCAGCACCTGCTAAACCGCACACTGGAAGTGGCCCTCTTGCTGGACACATTCTTCCGGCCCCTG AATGTACGAGTGGCACTAGTGGGCCTGGAGGCCTGGACCCAGCGTGACCTGGTGGAGATCAGCCCAAACCCAGCTGTCACCCTCGAAAACTTCCTCCACT GGCGCAGGGCACATTTGCTGCCTCGATTGCCCCATGACAGTGCCCAGCTGGTGACTGGTACTTCATTCTCTGGGCCTACGGTGGGCATGGCCATTCAGAA CTCCATCTGTTCTCCTGACTTCTCAGGAGGTGTGAACATGGACCACTCCACCAGCATCCTGGGAGTCGCCTCCTCCATAGCCCATGAGTTGGGCCACAGC CTGGGCCTGGACCATGATTTGCCTGGGAATAGCTGCCCCTGTCCAGGTCCAGCCCCAGCCAAGACCTGCATCATGGAGGCCTCCACAGACTTCCTACCAG GCCTGAACTTCAGCAACTGCAGCCGACGGGCCCTGGAGAAAGCCCTCCTGGATGGAATGGGCAGCTGCCTCTTCGAACGGCTGCCTAGCCTACCCCCTAT GGCTGCTTTCTGCGGAAATATGTTTGTGGAGCCGGGCGAGCAGTGTGACTGTGGCTTCCTGGATGACTGCGTCGATCCCTGCTGTGATTCTTTGACCTGC CAGCTGAGGCCAGGTGCACAGTGTGCATCTGACGGACCCTGTTGTCAAAATTGCCAGCTGCGCCCGTCTGGCTGGCAGTGTCGTCCTACCAGAGGGGATT GTGACTTGCCTGAATTCTGCCCAGGAGACAGCTCCCAGTGTCCCCCTGATGTCAGCCTAGGGGATGGCGAGCCCTGCGCTGGCGGGCAAGCTGTGTGCAT GCACGGGCGTTGTGCCTCCTATGCCCAGCAGTGCCAGTCACTTTGGGGACCTGGAGCCCAGCCCGCTGCGCCACTTTGCCTCCAGACAGCTAATACTCGG GGAAATGCTTTTGGGAGCTGTGGGCGCAACCCCAGTGGCAGTTATGTGTCCTGCACCCCTAGAGATGCCATTTGTGGGCAGCTCCAGTGCCAGACAGGTA GGACCCAGCCTCTGCTGGGCTCCATCCGGGATCTACTCTGGGAGACAATAGATGTGAATGGGACTGAGCTGAACTGCAGCTGGGTGCACCTGGACCTGGG CAGTGATGTGGCCCAGCCCCTCCTGACTCTGCCTGGCACAGCCTGTGGCCCTGGCCTGGTGTGTATAGACCATCGATGCCAGCGTGTGGATCTCCTGGGG GCACAGGAATGTCGAAGCAAATGCCATGGACATGGGGTCTGTGACAGCAACAGGCACTGCTACTGTGAGGAGGGCTGGGCACCCCCTGACTGCACCACTC AGCTCAAAGCAACCAGCTCCCTGACCACAGGGCTGCTCCTCAGCCTCCTGGTCTTATTGGTCCTGGTGATGCTTGGTGCCAGCTACTGGTACCGTGCCCG CCTGCACCAGCGACTCTGCCAGCTCAAGGGACCCACCTGCCAGTACAGGCTAGTGCTCTCAGCTTCCCGGCCCCCCCTTCCAGGCCGCTGCCGCCTGACC CTGTGTCCAAGAGACTCCAGTCTCAGGGGCCAGCCAAGCCCCCACCCCCAAGGAAGCCACTGCCTGCCGACCCCCAGGGCCGGTGCCCATCGGGTGACCT GCCCGGCCCAGGGGCTGGAATCCCGCCCCTAGTGGTACCCTCCAGACCAGCGCCACCGCCTCCGACAGTGTCCTCGCTCTACCTCTGACCTCTCCGGAGG TTCCGCTGCCTCCAAGCCGGACTTAGGGCTTCAAGAGGCGGGCGTGCCCTCTGGAGTCCCCTACCATGACTGAAGGCGCCAGAGACTGGCGGTGTCTTAA GACTCCGGGCACCGCCACGCGCTGTCAAGCAACACTCTGCGGACCTGCCGGCGTAGTTGCAGCGGGGGCTTGGGGAGGGGCTGGGGGTTGGACGGGATTG AGGAAGGTCCGCACAGCCTGTCTCTGCTCAGTTGCAATAAACGTGACATCTTGGGAGCGTTCCCCAGA

ADAM15.F7 (forward primer)
ADAM15.R2 (reverse primer)
Single exon skipping

Frame 0

LG*AAHCLACSRESLPARPLRARPRTGGREAAK LLGRGPDLAPGEGAPPKPVGPGTGSHSAQLRGSG SAEQRGRSGRCPRSRGTRRAAGRALPGAELGLG PGGRGRAGAGPGGRAALLGSPRRPGRRPLLRAL FRTCCPRPARSAAAMRLALLWALGLLGAGSPLPS WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDL PISLKKVLQTSLPEPLRIKLELDGDSHILELLQ NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTL EQGPGDLQGPPIISRIQDLHLPGHTCALSWRES VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIV ADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPL NVRVALVGLEAWTQRDLVEISPNPAVTLENFLH WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQN SICSPDFSGGVNMDHSTSILGVASSIAHELGHS LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLP GLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTC QLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCM HGRCASYAQQCQSLWGPGAQPAAPLCLQTANTR GNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTG RTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLG SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG AQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTT QLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR LHQRLCQLKGPTCQYRLVLSASRPPLPGRCRLT LCPRDSSLRGQPSPHPQGSHCLPTPRAGAHRVT CPAQGLESRP*WYPPDQRHRLRQCPRSTSDLSGG SAASKPDLGLQEAGVPSGVPYHD*RRQRLAVS* DSGHRHALSSNTLRTCRRSCSGGLGRGWGLDGI EEGPHSLSLLSCNKRDILGAFPR

Frame 1

WGEPRTASPAVGKACPPDLSEPGRAQEAGRPRS Y*GGVRTWRRVKARRPSRSDRAPAPTPHSCGEA VALSSAGVVGGVPAPEAPGAQRGGLCRGRSLAWG RVGGGGPGRGLVAARRCWVLRGDLAAGRSSARC SALAALARPGAPLPCGWRCSGPWGSWARAALCL PGRSQI*VALRSSRQSQRRPRGSPWSPRSFRTIS QLASKRCFRPVCLSP*GSSWSWTVTVISWSCYR IGSWSQAAQPWCGTSPMALGWSVRDTLWRTAAT REECGDMQAPGCPSAPALGSEAWWS*PQREAIPW SRGLGTFRVLPLFRESKISTCQATPVP*AGGNL YTLRSHQSTPWDSATFAGGGMW*QRPRLWSW*L WLITRRPRNTGTSSTC*TAHWKWPSCWTHSSGP* MYEWH*WAWRPGPSVTWWRSAQTQLSPSKTSST GAGHICCLDCPMTVPSW*LVLHSLGLRWAWPFR TPSVLLTSQEV*TWTTPPASWESPPP*PMSWATA WAWTMICLGIAAPVQVQPQPRPASWRPPQTSYQ A*TSATAADGPWRKPSWMEWAAASSNGCLAYPL WLLSAEICLWSRASSVTVASWMTASIPAVIL*PA S*GQVHSVHLTDPVVKIASCARLAGSVVLPEGI VTCLNSAQETAPSVPLMSA*GMASPALAGKLCA CTGVVPPMPSSASHFGDLEPSPLRHFASRQLILG EMLLGAVGATPVAVMCPAPLEMPFVGSSSARQV GPSLCWAPSGIYSGRQ*M*MGLS*TAAGCTWTW AVMWPSPS*LCLAQPVALAWCV*TIDASVWISWG HRNVEANAMDMGSVTATGTATVRRAGHPLTAPL SSKQPAP*PQGCSSASWSYWSW*CLVPATGTVP ACTSDSASSRDPPASTG*CSQLPGPPFQAAAA*P CVQETPVSGASQAPTPKEATACRPPGPVPIG*P ARPRGWNPAPSGTLQTSATASDSVLALPLTSPE VPLPPSRT*GFKRRACPLESPTMTEGARDWRCLK TPGTATRCQATLCGPAGVVAAGAWGGAGGWTGL RKVRTACLCSVAINVTSWERSP

Frame 2

GVSRALPRLQSGKPARPTSPSQAAHRRQGGREA TREGSGPGAG*RRAAQAGRTGHRLPLRTVAGKR *R*AARA*WAVSPLPRHPARSGAGFAGGGAWLG AGWEGAGRGGAWWPRGAAGFSEATWPPAAPPRAV PHLLPSPGPERRCHAAGAALGPGAPGRGQPSAF LAAPKYRWH*GAAGRVREGPEGALGAPGPSGRS PN*PQKGASDQSA*APEDQVGAGR*QSYPGAATE *GVGPRPPNPGVVPARWHSGGQ*GTHFGELLLP GKSAGICRLLGVHLHLLWAQRLGGPDPREKLYP GAGAWGPSGSSHYFANPRSPPARPHLCPELAGIC THSEATRAPPGTAPHSPEAGCGNRDQDCGVGDC G*SLGGPEIPGLPAPAKPHTGSGPLAGHILPAP ECTSGTSGPGGLDPA*PGGDQPKPSCHPRKLPPL AQGTFAASIAP*QCPAGDWYFILWAYGGHGHSE LHLFS*LLRRCEHGPLHQHPGSRLLHSP*VGPQ PGPGP*FAWE*LPLSRSSPSQDLHHGGLHRLPTR PELQQLQPTGPGESPPGWNGQLPLRTAA*PTPY GCFLRKYVCGAGRAV*LWLPG*LRRSLL*FFDL PAEARCTVCI*RTLLSKLPAAPVWLAVSSYQRGL *LA*ILPRRQLPVSP*CQPRGWRALRWRASCVH ARALCLLCPAVPVTLGTWSPARCATLPPDS*YS GKCFWELWAQPQWQLCVLHP*RCHLWAAPVPDR* DPASAGLHPGSTLGDNRCEWD*AELQLGAPGPG Q*CGPAPPDSAWHSLWPWPGVYRPSMPACGSPG GTGMSKQMPWTWGL*QQQALLL*GGLGTP*LHHS AQSNQLPDHRAAPQPPGLIGPGDAWCQLLVPCP PAPATLPAQGTHLPVQASALSFPAPPSRPLPPD PVSKRLQSQGPAKPPPPRKPLPADPQGRCPSGDL PGPGAGIPPLVVPSRPAPPPPTVSSLYL*PLRR FRCLQAGLRASRGGRALWSPLP*LKAPETGGVL RLRAPPRAVKQHSADLPA*LQRGLGEGLGVGRD* GRSAQPVSAQLQ*T*HLGSVPQ

Sequence ADAM15.nAug05

TTTGGGAGCTGTGGGCGCAACCCCAGTGGCAGTTATGTGTCCTGCACCCCTAGAGATGCCATTTGTGGGCAGCTCCAGTGCCAGACAGGTAGGACCCAGC CTCTGCTGGGCTCCATCCGGGATCTACTCTGGGAGACAATAGATGTGAATGGGACTGAGCTGAACTGCAGCTGGGTGCACCTGGACCTGGGCAGTGATGT GGCCCAGCCCCTCCTGACTCTGCCTGGCACAGCCTGTGGCCCTGGCCTGGTGTGTATAGACCATCGATGCCAGCGTGTGGATCTCCTGGGGGCACAGGAA TGTCGAAGCAAATGCCATGGACATGGGGTCTGTGACAGCAACAGGCACTGCTACTGTGAGGAGGGCTGGGCACCCCCTGACTGCACCACTCAGCTCAAAG CAACCAGCTCCCTGACCACAGGGCTGCTCCTCAGCCTCCTGGTCTTATTGGTCCTGGTGATGCTTGGTGCCAGCTACTGGTACCGTGCCCGCCTGCACCA GCGACTCTGCCAGCTCAAGGGACCCACCTGCCAGTACAGGGCAGCCCAATCTGGTCCCTCTGAACGGCCAGGACCTCCGCAGAGGGCCCTGCTGGCACGA GGCACTAAGGCTAGTGCTCTCAGCTTCCCGGCCCCCCCTTCCAGGCCGCTGCCGCCTGACCCTGTGTCCAAGAGACTCCAGTCTCAGGGGCCAGCCAAGC CCCCACCCCCAAGGAAGCCACTGCCTGCCGACCCCCAGGGCCGGTGCCCATCGGGTGACCTGCCCGGCCCAGGGGCTGGAATCCCGCCCCTAGTGGTACC CTCCAGACCAGCGCCACCGCCTCCGACAGTGTCCTCGCTCTACCTCTGACCTCTCCGGAGGTTCCGCTGCCTCCAAGCCGGACTTAGGGCTTCAAGAGGC GGGCGTGCCCTCTGGAGTCCCCTACCATGACTGAAGGCGCCAGAGACTGGCGGTGTCTTAAGACTCCGGGCACCGCCACGCGCTGTCAAGCAACACTCTG CGGACCTGCCGGCGTAGTTGCAGCGGGGGCTTGGGGAGGGGCTGGGGGTTGGACGGGATTGAGGAAGGTCCGCACAGCCTGTCTCTGCTCAGTTGCAATA AACGTGACATCTTGGGAGCGTTCCCCAGA

ADAM15.F7 (forward primer)
ADAM15.R2 (reverse primer)
Single exon skipping

Frame 0

FGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQ PLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDV AQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQE CRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLK ATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQ RLCQLKGPTCQYRAAQSGPSERPGPPQRALLAR GTKASALSFPAPPSRPLPPDPVSKRLQSQGPAK PPPPRKPLPADPQGRCPSGDLPGPGAGIPPLVVP SRPAPPPPTVSSLYL*PLRRFRCLQAGLRASRG GRALWSPLP*LKAPETGGVLRLRAPPRAVKQHS ADLPA*LQRGLGEGLGVGRD*GRSAQPVSAQLQ* T*HLGSVPQ

Frame 1

LGAVGATPVAVMCPAPLEMPFVGSSSARQVGPS LCWAPSGIYSGRQ*M*MGLS*TAAGCTWTWAVM WPSPS*LCLAQPVALAWCV*TIDASVWISWGHRN VEANAMDMGSVTATGTATVRRAGHPLTAPLSSK QPAP*PQGCSSASWSYWSW*CLVPATGTVPACT SDSASSRDPPASTGQPNLVPLNGQDLRRGPCWHE ALRLVLSASRPPLPGRCRLTLCPRDSSLRGQPS PHPQGSHCLPTPRAGAHRVTCPAQGLESRP*WY PPDQRHRLRQCPRSTSDLSGGSAASKPDLGLQEA GVPSGVPYHD*RRQRLAVS*DSGHRHALSSNTL RTCRRSCSGGLGRGWGLDGIEEGPHSLSLLSCN KRDILGAFPR

Frame 2

WELWAQPQWQLCVLHP*RCHLWAAPVPDR*DPA SAGLHPGSTLGDNRCEWD*AELQLGAPGPGQ*C GPAPPDSAWHSLWPWPGVYRPSMPACGSPGGTG MSKQMPWTWGL*QQQALLL*GGLGTP*LHHSAQS NQLPDHRAAPQPPGLIGPGDAWCQLLVPCPPAP ATLPAQGTHLPVQGSPIWSL*TARTSAEGPAGT RH*G*CSQLPGPPFQAAAA*PCVQETPVSGASQA PTPKEATACRPPGPVPIG*PARPRGWNPAPSGT LQTSATASDSVLALPLTSPEVPLPPSRT*GFKR RACPLESPTMTEGARDWRCLKTPGTATRCQATLC GPAGVVAAGAWGGAGGWTGLRKVRTACLCSVAI NVTSWERSP

Sequence ADAM15.oAug05

TTTGGGAGCTGTGGGCGCAACCCCAGTGGCAGTTATGTGTCCTGCACCCCTAGAGATGCCATTTGTGGGCAGCTCCAGTGCCAGACAGGTAGGACCCAGC CTCTGCTGGGCTCCATCCGGGATCTACTCTGGGAGACAATAGATGTGAATGGGACTGAGCTGAACTGCAGCTGGGTGCACCTGGACCTGGGCAGTGATGT GGCCCAGCCCCTCCTGACTCTGCCTGGCACAGCCTGTGGCCCTGGCCTGGTGTGTATAGACCATCGATGCCAGCGTGTGGATCTCCTGGGGGCACAGGAA TGTCGAAGCAAATGCCATGGACATGGGGTCTGTGACAGCAACAGGCACTGCTACTGTGAGGAGGGCTGGGCACCCCCTGACTGCACCACTCAGCTCAAAG CAACCAGCTCCCTGACCACAGGGCTGCTCCTCAGCCTCCTGGTCTTATTGGTCCTGGTGATGCTTGGTGCCAGCTACTGGTACCGTGCCCGCCTGCACCA GCGACTCTGCCAGCTCAAGGGACCCACCTGCCAGTACAGGGCAGCCCAATCTGGTCCCTCTGAACGGCCAGGACCTCCGCAGAGGGCCCTGCTGGCACGA GGCACTAAGGCTAGTGCTCTCAGCTTCCCGGCCCCCCCTTCCAGGCCGCTGCCGCCTGACCCTGTGTCCAAGAGACTCCAGTGGTGCTCTTCATTAGGTG ATCGGGGTGCCCCTCAGCCTTCAGACACTCTGAGCCCCAGAAGCAGCAAAGGTCTCAGGGGCCAGCCAAGCCCCCACCCCCAAGGAAGCCACTGCCTGCC GACCCCCAGGGCCGGTGCCCATCGGGTGACCTGCCCGGCCCAGGGGCTGGAATCCCGCCCCTAGTGGTACCCTCCAGACCAGCGCCACCGCCTCCGACAG TGTCCTCGCTCTACCTCTGACCTCTCCGGAGGTTCCGCTGCCTCCAAGCCGGACTTAGGGCTTCAAGAGGCGGGCGTGCCCTCTGGAGTCCCCTACCATG ACTGAAGGCGCCAGAGACTGGCGGTGTCTTAAGACTCCGGGCACCGCCACGCGCTGTCAAGCAACACTCTGCGGACCTGCCGGCGTAGTTGCAGCGGGGG CTTGGGGAGGGGCTGGGGGTTGGACGGGATTGAGGAAGGTCCGCACAGCCTGTCTCTGCTCAGTTGCAATAAACGTGACATCTTGGGAGCGTTCCCCAGA

ADAM15.F7 (forward primer)
ADAM15.R2 (reverse primer)
Single exon skipping

Frame 0

FGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQ PLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDV AQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQE CRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLK ATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQ RLCQLKGPTCQYRAAQSGPSERPGPPQRALLAR GTKASALSFPAPPSRPLPPDPVSKRLQWCSSLG DRGAPQPSDTLSPRSSKGLRGQPSPHPQGSHCLP TPRAGAHRVTCPAQGLESRP*WYPPDQRHRLRQ CPRSTSDLSGGSAASKPDLGLQEAGVPSGVPYH D*RRQRLAVS*DSGHRHALSSNTLRTCRRSCSGG LGRGWGLDGIEEGPHSLSLLSCNKRDILGAFPR

Frame 1

LGAVGATPVAVMCPAPLEMPFVGSSSARQVGPS LCWAPSGIYSGRQ*M*MGLS*TAAGCTWTWAVM WPSPS*LCLAQPVALAWCV*TIDASVWISWGHRN VEANAMDMGSVTATGTATVRRAGHPLTAPLSSK QPAP*PQGCSSASWSYWSW*CLVPATGTVPACT SDSASSRDPPASTGQPNLVPLNGQDLRRGPCWHE ALRLVLSASRPPLPGRCRLTLCPRDSSGALH*V IGVPLSLQTL*APEAAKVSGASQAPTPKEATAC RPPGPVPIG*PARPRGWNPAPSGTLQTSATASDS VLALPLTSPEVPLPPSRT*GFKRRACPLESPTM TEGARDWRCLKTPGTATRCQATLCGPAGVVAAG AWGGAGGWTGLRKVRTACLCSVAINVTSWERSP

Frame 2

WELWAQPQWQLCVLHP*RCHLWAAPVPDR*DPA SAGLHPGSTLGDNRCEWD*AELQLGAPGPGQ*C GPAPPDSAWHSLWPWPGVYRPSMPACGSPGGTG MSKQMPWTWGL*QQQALLL*GGLGTP*LHHSAQS NQLPDHRAAPQPPGLIGPGDAWCQLLVPCPPAP ATLPAQGTHLPVQGSPIWSL*TARTSAEGPAGT RH*G*CSQLPGPPFQAAAA*PCVQETPVVLFIR* SGCPSAFRHSEPQKQQRSQGPAKPPPPRKPLPA DPQGRCPSGDLPGPGAGIPPLVVPSRPAPPPPT VSSLYL*PLRRFRCLQAGLRASRGGRALWSPLP* LKAPETGGVLRLRAPPRAVKQHSADLPA*LQRG LGEGLGVGRD*GRSAQPVSAQLQ*T*HLGSVPQ