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Sequences

Sequence ADAM15.iAug05

CTGGGGTGAGCCGCGCACTGCCTCGCCTGCAGTCGGGAAAGCCTGCCCGCCCGACCTCTCCGAGCCAGGCCGCGCACAGGAGGCAGGGAGGCCGCGAAGC TACTAGGGAGGGGTCCGGACCTGGCGCCGGGTGAAGGCGCGCCGCCCAAGCCGGTCGGACCGGGCACCGGCTCCCACTCCGCACAGTTGCGGGGAAGCGG TAGCGCTGAGCAGCGCGGGCGTAGTGGGCGGTGTCCCCGCTCCCGAGGCACCCGGCGCGCAGCGGGGCGGGCTTTGCCGGGGGCGGAGCTTGGCTTGGGG CCGGGTGGGAGGGGGCGGGCCGGGGCGGGGCCTGGTGGCCGCGCGGCGCTGCTGGGTTCTCCGAGGCGACCTGGCCGCCGGCCGCTCCTCCGCGCGCTGT TCCGCACTTGCTGCCCTCGCCCGGCCCGGAGCGCCGCTGCCATGCGGCTGGCGCTGCTCTGGGCCCTGGGGCTCCTGGGCGCGGGCAGCCCTCTGCCTTC CTGGCCGCTCCCAAATATAGGTGGCACTGAGGAGCAGCAGGCAGAGTCAGAGAAGGCCCCGAGGGAGCCCTTGGAGCCCCAGGTCCTTCAGGACGATCTC CCAATTAGCCTCAAAAAGGTGCTTCAGACCAGTCTGCCTGAGCCCCTGAGGATCAAGTTGGAGCTGGACGGTGACAGTCATATCCTGGAGCTGCTACAGA ATAGGGAGTTGGTCCCAGGCCGCCCAACCCTGGTGTGGTACCAGCCCGATGGCACTCGGGTGGTCAGTGAGGGACACACTTTGGAGAACTGCTGCTACCA GGGAAGAGTGCGGGGATATGCAGGCTCCTGGGTGTCCATCTGCACCTGCTCTGGGCTCAGAGGCTTGGTGGTCCTGACCCCAGAGAGAAGCTATACCCTG GAGCAGGGGCCTGGGGACCTTCAGGGTCCTCCCATTATTTCGCGAATCCAAGATCTCCACCTGCCAGGCCACACCTGTGCCCTGAGCTGGCGGGAATCTG TACACACTCAGAAGCCACCAGAGCACCCCCTGGGACAGCGCCACATTCGCCGGAGGCGGGATGTGGTAACAGAGACCAAGACTGTGGAGTTGGTGATTGT GGCTGATCACTCGGAGGCCCAGAAATACCGGGACTTCCAGCACCTGCTAAACCGCACACTGGAAGTGGCCCTCTTGCTGGACACATTCTTCCGGCCCCTG AATGTACGAGTGGCACTAGTGGGCCTGGAGGCCTGGACCCAGCGTGACCTGGTGGAGATCAGCCCAAACCCAGCTGTCACCCTCGAAAACTTCCTCCACT GGCGCAGGGCACATTTGCTGCCTCGATTGCCCCATGACAGTGCCCAGCTGGTGACTGGTACTTCATTCTCTGGGCCTACGGTGGGCATGGCCATTCAGAA CTCCATCTGTTCTCCTGACTTCTCAGGAGGTGTGAACATGGACCACTCCACCAGCATCCTGGGAGTCGCCTCCTCCATAGCCCATGAGTTGGGCCACAGC CTGGGCCTGGACCATGATTTGCCTGGGAATAGCTGCCCCTGTCCAGGTCCAGCCCCAGCCAAGACCTGCATCATGGAGGCCTCCACAGACTTCCTACCAG GCCTGAACTTCAGCAACTGCAGCCGACGGGCCCTGGAGAAAGCCCTCCTGGATGGAATGGGCAGCTGCCTCTTCGAACGGCTGCCTAGCCTACCCCCTAT GGCTGCTTTCTGCGGAAATATGTTTGTGGAGCCGGGCGAGCAGTGTGACTGTGGCTTCCTGGATGACTGCGTCGATCCCTGCTGTGATTCTTTGACCTGC CAGCTGAGGCCAGGTGCACAGTGTGCATCTGACGGACCCTGTTGTCAAAATTGCCAGCTGCGCCCGTCTGGCTGGCAGTGTCGTCCTACCAGAGGGGATT GTGACTTGCCTGAATTCTGCCCAGGAGACAGCTCCCAGTGTCCCCCTGATGTCAGCCTAGGGGATGGCGAGCCCTGCGCTGGCGGGCAAGCTGTGTGCAT GCACGGGCGTTGTGCCTCCTATGCCCAGCAGTGCCAGTCACTTTGGGGACCTGGAGCCCAGCCCGCTGCGCCACTTTGCCTCCAGACAGCTAATACTCGG GGAAATGCTTTTGGGAGCTGTGGGCGCAACCCCAGTGGCAGTTATGTGTCCTGCACCCCTAGAGATGCCATTTGTGGGCAGCTCCAGTGCCAGACAGGTA GGACCCAGCCTCTGCTGGGCTCCATCCGGGATCTACTCTGGGAGACAATAGATGTGAATGGGACTGAGCTGAACTGCAGCTGGGTGCACCTGGACCTGGG CAGTGATGTGGCCCAGCCCCTCCTGACTCTGCCTGGCACAGCCTGTGGCCCTGGCCTGGTGTGTATAGACCATCGATGCCAGCGTGTGGATCTCCTGGGG GCACAGGAATGTCGAAGCAAATGCCATGGACATGGGGTCTGTGACAGCAACAGGCACTGCTACTGTGAGGAGGGCTGGGCACCCCCTGACTGCACCACTC AGCTCAAAGCAACCAGCTCCCTGACCACAGGGCTGCTCCTCAGCCTCCTGGTCTTATTGGTCCTGGTGATGCTTGGTGCCAGCTACTGGTACCGTGCCCG CCTGCACCAGCGACTCTGCCAGCTCAAGGGACCCACCTGCCAGTACAGGGCAGCCCAATCTGGTCCCTCTGAACGGCCAGGACCTCCGCAGAGGGCCCTG CTGGCACGAGGCACTAAGGCTGAGCTGGCTGACCGACCCAATCCCCCTACCCGCCCTCTGCCCGCTGACCCGGTGGTGAGAAGCCCGAAGGTAACGGTGG GGGGAGAGAAGGGCACGGCCTCTCCCCCCACCTAGGGCTGTGGTGCTGGTAGCCATGACGGTGGTGGCCGTGGCGAGATGCCCCCTCAGTGCATGAGGGC ACATATCCCGGTGGTGCCTTTAATGGTGACAGTCTCAGGGGCCAGCCAAGCCCCCACCCCCAAGGAAGCCACTGCCTGCCGACCCCCAGGGCCGGTGCCC ATCGGGTGACCTGCCCGGCCCAGGGGCTGGAATCCCGCCCCTAGTGGTACCCTCCAGACCAGCGCCACCGCCTCCGACAGTGTCCTCGCTCTACCTCTGA CCTCTCCGGAGGTTCCGCTGCCTCCAAGCCGGACTTAGGGCTTCAAGAGGCGGGCGTGCCCTCTGGAGTCCCCTACCATGACTGAAGGCGCCAGAGACTG GCGGTGTCTTAAGACTCCGGGCACCGCCACGCGCTGTCAAGCAACACTCTGCGGACCTGCCGGCGTAGTTGCAGCGGGGGCTTGGGGAGGGGCTGGGGGT TGGACGGGATTGAGGAAGGTCCGCACAGCCTGTCTCTGCTCAGTTGCAATAAACGTGACATCTTGGGAGCGTTCCCCAGA

ADAM15.F7 (forward primer)
ADAM15.R2 (reverse primer)
Single exon skipping

Frame 0

LG*AAHCLACSRESLPARPLRARPRTGGREAAK LLGRGPDLAPGEGAPPKPVGPGTGSHSAQLRGSG SAEQRGRSGRCPRSRGTRRAAGRALPGAELGLG PGGRGRAGAGPGGRAALLGSPRRPGRRPLLRAL FRTCCPRPARSAAAMRLALLWALGLLGAGSPLPS WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDL PISLKKVLQTSLPEPLRIKLELDGDSHILELLQ NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTL EQGPGDLQGPPIISRIQDLHLPGHTCALSWRES VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIV ADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPL NVRVALVGLEAWTQRDLVEISPNPAVTLENFLH WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQN SICSPDFSGGVNMDHSTSILGVASSIAHELGHS LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLP GLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTC QLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCM HGRCASYAQQCQSLWGPGAQPAAPLCLQTANTR GNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTG RTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLG SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG AQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTT QLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRAL LARGTKAELADRPNPPTRPLPADPVVRSPKVTV GGEKGTASPPT*GCGAGSHDGGGRGEMPPQCMRA HIPVVPLMVTVSGASQAPTPKEATACRPPGPVP IG*PARPRGWNPAPSGTLQTSATASDSVLALPL TSPEVPLPPSRT*GFKRRACPLESPTMTEGARDW RCLKTPGTATRCQATLCGPAGVVAAGAWGGAGG WTGLRKVRTACLCSVAINVTSWERSP

Frame 1

WGEPRTASPAVGKACPPDLSEPGRAQEAGRPRS Y*GGVRTWRRVKARRPSRSDRAPAPTPHSCGEA VALSSAGVVGGVPAPEAPGAQRGGLCRGRSLAWG RVGGGGPGRGLVAARRCWVLRGDLAAGRSSARC SALAALARPGAPLPCGWRCSGPWGSWARAALCL PGRSQI*VALRSSRQSQRRPRGSPWSPRSFRTIS QLASKRCFRPVCLSP*GSSWSWTVTVISWSCYR IGSWSQAAQPWCGTSPMALGWSVRDTLWRTAAT REECGDMQAPGCPSAPALGSEAWWS*PQREAIPW SRGLGTFRVLPLFRESKISTCQATPVP*AGGNL YTLRSHQSTPWDSATFAGGGMW*QRPRLWSW*L WLITRRPRNTGTSSTC*TAHWKWPSCWTHSSGP* MYEWH*WAWRPGPSVTWWRSAQTQLSPSKTSST GAGHICCLDCPMTVPSW*LVLHSLGLRWAWPFR TPSVLLTSQEV*TWTTPPASWESPPP*PMSWATA WAWTMICLGIAAPVQVQPQPRPASWRPPQTSYQ A*TSATAADGPWRKPSWMEWAAASSNGCLAYPL WLLSAEICLWSRASSVTVASWMTASIPAVIL*PA S*GQVHSVHLTDPVVKIASCARLAGSVVLPEGI VTCLNSAQETAPSVPLMSA*GMASPALAGKLCA CTGVVPPMPSSASHFGDLEPSPLRHFASRQLILG EMLLGAVGATPVAVMCPAPLEMPFVGSSSARQV GPSLCWAPSGIYSGRQ*M*MGLS*TAAGCTWTW AVMWPSPS*LCLAQPVALAWCV*TIDASVWISWG HRNVEANAMDMGSVTATGTATVRRAGHPLTAPL SSKQPAP*PQGCSSASWSYWSW*CLVPATGTVP ACTSDSASSRDPPASTGQPNLVPLNGQDLRRGPC WHEALRLSWLTDPIPLPALCPLTRW*EARR*RW GERRARPLPPPRAVVLVAMTVVAVARCPLSA*G HISRWCL*W*QSQGPAKPPPPRKPLPADPQGRCP SGDLPGPGAGIPPLVVPSRPAPPPPTVSSLYL* PLRRFRCLQAGLRASRGGRALWSPLP*LKAPET GGVLRLRAPPRAVKQHSADLPA*LQRGLGEGLGV GRD*GRSAQPVSAQLQ*T*HLGSVPQ

Frame 2

GVSRALPRLQSGKPARPTSPSQAAHRRQGGREA TREGSGPGAG*RRAAQAGRTGHRLPLRTVAGKR *R*AARA*WAVSPLPRHPARSGAGFAGGGAWLG AGWEGAGRGGAWWPRGAAGFSEATWPPAAPPRAV PHLLPSPGPERRCHAAGAALGPGAPGRGQPSAF LAAPKYRWH*GAAGRVREGPEGALGAPGPSGRS PN*PQKGASDQSA*APEDQVGAGR*QSYPGAATE *GVGPRPPNPGVVPARWHSGGQ*GTHFGELLLP GKSAGICRLLGVHLHLLWAQRLGGPDPREKLYP GAGAWGPSGSSHYFANPRSPPARPHLCPELAGIC THSEATRAPPGTAPHSPEAGCGNRDQDCGVGDC G*SLGGPEIPGLPAPAKPHTGSGPLAGHILPAP ECTSGTSGPGGLDPA*PGGDQPKPSCHPRKLPPL AQGTFAASIAP*QCPAGDWYFILWAYGGHGHSE LHLFS*LLRRCEHGPLHQHPGSRLLHSP*VGPQ PGPGP*FAWE*LPLSRSSPSQDLHHGGLHRLPTR PELQQLQPTGPGESPPGWNGQLPLRTAA*PTPY GCFLRKYVCGAGRAV*LWLPG*LRRSLL*FFDL PAEARCTVCI*RTLLSKLPAAPVWLAVSSYQRGL *LA*ILPRRQLPVSP*CQPRGWRALRWRASCVH ARALCLLCPAVPVTLGTWSPARCATLPPDS*YS GKCFWELWAQPQWQLCVLHP*RCHLWAAPVPDR* DPASAGLHPGSTLGDNRCEWD*AELQLGAPGPG Q*CGPAPPDSAWHSLWPWPGVYRPSMPACGSPG GTGMSKQMPWTWGL*QQQALLL*GGLGTP*LHHS AQSNQLPDHRAAPQPPGLIGPGDAWCQLLVPCP PAPATLPAQGTHLPVQGSPIWSL*TARTSAEGP AGTRH*G*AG*PTQSPYPPSAR*PGGEKPEGNGG GREGHGLSPHLGLWCW*P*RWWPWRDAPSVHEG TYPGGAFNGDSLRGQPSPHPQGSHCLPTPRAGA HRVTCPAQGLESRP*WYPPDQRHRLRQCPRSTSD LSGGSAASKPDLGLQEAGVPSGVPYHD*RRQRL AVS*DSGHRHALSSNTLRTCRRSCSGGLGRGWG LDGIEEGPHSLSLLSCNKRDILGAFPR

Sequence ADAM15.dAug05

CTGGGGTGAGCCGCGCACTGCCTCGCCTGCAGTCGGGAAAGCCTGCCCGCCCGACCTCTCCGAGCCAGGCCGCGCACAGGAGGCAGGGAGGCCGCGAAGC TACTAGGGAGGGGTCCGGACCTGGCGCCGGGTGAAGGCGCGCCGCCCAAGCCGGTCGGACCGGGCACCGGCTCCCACTCCGCACAGTTGCGGGGAAGCGG TAGCGCTGAGCAGCGCGGGCGTAGTGGGCGGTGTCCCCGCTCCCGAGGCACCCGGCGCGCAGCGGGGCGGGCTTTGCCGGGGGCGGAGCTTGGCTTGGGG CCGGGTGGGAGGGGGCGGGCCGGGGCGGGGCCTGGTGGCCGCGCGGCGCTGCTGGGTTCTCCGAGGCGACCTGGCCGCCGGCCGCTCCTCCGCGCGCTGT TCCGCACTTGCTGCCCTCGCCCGGCCCGGAGCGCCGCTGCCATGCGGCTGGCGCTGCTCTGGGCCCTGGGGCTCCTGGGCGCGGGCAGCCCTCTGCCTTC CTGGCCGCTCCCAAATATAGGTGGCACTGAGGAGCAGCAGGCAGAGTCAGAGAAGGCCCCGAGGGAGCCCTTGGAGCCCCAGGTCCTTCAGGACGATCTC CCAATTAGCCTCAAAAAGGTGCTTCAGACCAGTCTGCCTGAGCCCCTGAGGATCAAGTTGGAGCTGGACGGTGACAGTCATATCCTGGAGCTGCTACAGA ATAGGGAGTTGGTCCCAGGCCGCCCAACCCTGGTGTGGTACCAGCCCGATGGCACTCGGGTGGTCAGTGAGGGACACACTTTGGAGAACTGCTGCTACCA GGGAAGAGTGCGGGGATATGCAGGCTCCTGGGTGTCCATCTGCACCTGCTCTGGGCTCAGAGGCTTGGTGGTCCTGACCCCAGAGAGAAGCTATACCCTG GAGCAGGGGCCTGGGGACCTTCAGGGTCCTCCCATTATTTCGCGAATCCAAGATCTCCACCTGCCAGGCCACACCTGTGCCCTGAGCTGGCGGGAATCTG TACACACTCAGAAGCCACCAGAGCACCCCCTGGGACAGCGCCACATTCGCCGGAGGCGGGATGTGGTAACAGAGACCAAGACTGTGGAGTTGGTGATTGT GGCTGATCACTCGGAGGCCCAGAAATACCGGGACTTCCAGCACCTGCTAAACCGCACACTGGAAGTGGCCCTCTTGCTGGACACATTCTTCCGGCCCCTG AATGTACGAGTGGCACTAGTGGGCCTGGAGGCCTGGACCCAGCGTGACCTGGTGGAGATCAGCCCAAACCCAGCTGTCACCCTCGAAAACTTCCTCCACT GGCGCAGGGCACATTTGCTGCCTCGATTGCCCCATGACAGTGCCCAGCTGGTGACTGGTACTTCATTCTCTGGGCCTACGGTGGGCATGGCCATTCAGAA CTCCATCTGTTCTCCTGACTTCTCAGGAGGTGTGAACATGGACCACTCCACCAGCATCCTGGGAGTCGCCTCCTCCATAGCCCATGAGTTGGGCCACAGC CTGGGCCTGGACCATGATTTGCCTGGGAATAGCTGCCCCTGTCCAGGTCCAGCCCCAGCCAAGACCTGCATCATGGAGGCCTCCACAGACTTCCTACCAG GCCTGAACTTCAGCAACTGCAGCCGACGGGCCCTGGAGAAAGCCCTCCTGGATGGAATGGGCAGCTGCCTCTTCGAACGGCTGCCTAGCCTACCCCCTAT GGCTGCTTTCTGCGGAAATATGTTTGTGGAGCCGGGCGAGCAGTGTGACTGTGGCTTCCTGGATGACTGCGTCGATCCCTGCTGTGATTCTTTGACCTGC CAGCTGAGGCCAGGTGCACAGTGTGCATCTGACGGACCCTGTTGTCAAAATTGCCAGCTGCGCCCGTCTGGCTGGCAGTGTCGTCCTACCAGAGGGGATT GTGACTTGCCTGAATTCTGCCCAGGAGACAGCTCCCAGTGTCCCCCTGATGTCAGCCTAGGGGATGGCGAGCCCTGCGCTGGCGGGCAAGCTGTGTGCAT GCACGGGCGTTGTGCCTCCTATGCCCAGCAGTGCCAGTCACTTTGGGGACCTGGAGCCCAGCCCGCTGCGCCACTTTGCCTCCAGACAGCTAATACTCGG GGAAATGCTTTTGGGAGCTGTGGGCGCAACCCCAGTGGCAGTTATGTGTCCTGCACCCCTAGAGATGCCATTTGTGGGCAGCTCCAGTGCCAGACAGGTA GGACCCAGCCTCTGCTGGGCTCCATCCGGGATCTACTCTGGGAGACAATAGATGTGAATGGGACTGAGCTGAACTGCAGCTGGGTGCACCTGGACCTGGG CAGTGATGTGGCCCAGCCCCTCCTGACTCTGCCTGGCACAGCCTGTGGCCCTGGCCTGGTGTGTATAGACCATCGATGCCAGCGTGTGGATCTCCTGGGG GCACAGGAATGTCGAAGCAAATGCCATGGACATGGGGTCTGTGACAGCAACAGGCACTGCTACTGTGAGGAGGGCTGGGCACCCCCTGACTGCACCACTC AGCTCAAAGCAACCAGCTCCCTGACCACAGGGCTGCTCCTCAGCCTCCTGGTCTTATTGGTCCTGGTGATGCTTGGTGCCAGCTACTGGTACCGTGCCCG CCTGCACCAGCGACTCTGCCAGCTCAAGGGACCCACCTGCCAGTACAGGGCAGCCCAATCTGGTCCCTCTGAACGGCCAGGACCTCCGCAGAGGGCCCTG CTGGCACGAGGCACTAAGGCTGAGCTGGCTGACCGACCCAATCCCCCTACCCGCCCTCTGCCCGCTGACCCGGTGGTGAGAAGCCCGAAGTCTCAGGGGC CAGCCAAGCCCCCACCCCCAAGGAAGCCACTGCCTGCCGACCCCCAGGGCCGGTGCCCATCGGGTGACCTGCCCGGCCCAGGGGCTGGAATCCCGCCCCT AGTGGTACCCTCCAGACCAGCGCCACCGCCTCCGACAGTGTCCTCGCTCTACCTCTGACCTCTCCGGAGGTTCCGCTGCCTCCAAGCCGGACTTAGGGCT TCAAGAGGCGGGCGTGCCCTCTGGAGTCCCCTACCATGACTGAAGGCGCCAGAGACTGGCGGTGTCTTAAGACTCCGGGCACCGCCACGCGCTGTCAAGC AACACTCTGCGGACCTGCCGGCGTAGTTGCAGCGGGGGCTTGGGGAGGGGCTGGGGGTTGGACGGGATTGAGGAAGGTCCGCACAGCCTGTCTCTGCTCA GTTGCAATAAACGTGACATCTTGGGAGCGTTCCCCAGA

ADAM15.F7 (forward primer)
ADAM15.R2 (reverse primer)
Single exon skipping

Frame 0

LG*AAHCLACSRESLPARPLRARPRTGGREAAK LLGRGPDLAPGEGAPPKPVGPGTGSHSAQLRGSG SAEQRGRSGRCPRSRGTRRAAGRALPGAELGLG PGGRGRAGAGPGGRAALLGSPRRPGRRPLLRAL FRTCCPRPARSAAAMRLALLWALGLLGAGSPLPS WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDL PISLKKVLQTSLPEPLRIKLELDGDSHILELLQ NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTL EQGPGDLQGPPIISRIQDLHLPGHTCALSWRES VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIV ADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPL NVRVALVGLEAWTQRDLVEISPNPAVTLENFLH WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQN SICSPDFSGGVNMDHSTSILGVASSIAHELGHS LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLP GLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTC QLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCM HGRCASYAQQCQSLWGPGAQPAAPLCLQTANTR GNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTG RTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLG SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG AQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTT QLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRAL LARGTKAELADRPNPPTRPLPADPVVRSPKSQG PAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPL VVPSRPAPPPPTVSSLYL*PLRRFRCLQAGLRA SRGGRALWSPLP*LKAPETGGVLRLRAPPRAVK QHSADLPA*LQRGLGEGLGVGRD*GRSAQPVSAQ LQ*T*HLGSVPQ

Frame 1

WGEPRTASPAVGKACPPDLSEPGRAQEAGRPRS Y*GGVRTWRRVKARRPSRSDRAPAPTPHSCGEA VALSSAGVVGGVPAPEAPGAQRGGLCRGRSLAWG RVGGGGPGRGLVAARRCWVLRGDLAAGRSSARC SALAALARPGAPLPCGWRCSGPWGSWARAALCL PGRSQI*VALRSSRQSQRRPRGSPWSPRSFRTIS QLASKRCFRPVCLSP*GSSWSWTVTVISWSCYR IGSWSQAAQPWCGTSPMALGWSVRDTLWRTAAT REECGDMQAPGCPSAPALGSEAWWS*PQREAIPW SRGLGTFRVLPLFRESKISTCQATPVP*AGGNL YTLRSHQSTPWDSATFAGGGMW*QRPRLWSW*L WLITRRPRNTGTSSTC*TAHWKWPSCWTHSSGP* MYEWH*WAWRPGPSVTWWRSAQTQLSPSKTSST GAGHICCLDCPMTVPSW*LVLHSLGLRWAWPFR TPSVLLTSQEV*TWTTPPASWESPPP*PMSWATA WAWTMICLGIAAPVQVQPQPRPASWRPPQTSYQ A*TSATAADGPWRKPSWMEWAAASSNGCLAYPL WLLSAEICLWSRASSVTVASWMTASIPAVIL*PA S*GQVHSVHLTDPVVKIASCARLAGSVVLPEGI VTCLNSAQETAPSVPLMSA*GMASPALAGKLCA CTGVVPPMPSSASHFGDLEPSPLRHFASRQLILG EMLLGAVGATPVAVMCPAPLEMPFVGSSSARQV GPSLCWAPSGIYSGRQ*M*MGLS*TAAGCTWTW AVMWPSPS*LCLAQPVALAWCV*TIDASVWISWG HRNVEANAMDMGSVTATGTATVRRAGHPLTAPL SSKQPAP*PQGCSSASWSYWSW*CLVPATGTVP ACTSDSASSRDPPASTGQPNLVPLNGQDLRRGPC WHEALRLSWLTDPIPLPALCPLTRW*EARSLRG QPSPHPQGSHCLPTPRAGAHRVTCPAQGLESRP *WYPPDQRHRLRQCPRSTSDLSGGSAASKPDLGL QEAGVPSGVPYHD*RRQRLAVS*DSGHRHALSS NTLRTCRRSCSGGLGRGWGLDGIEEGPHSLSLL SCNKRDILGAFPR

Frame 2

GVSRALPRLQSGKPARPTSPSQAAHRRQGGREA TREGSGPGAG*RRAAQAGRTGHRLPLRTVAGKR *R*AARA*WAVSPLPRHPARSGAGFAGGGAWLG AGWEGAGRGGAWWPRGAAGFSEATWPPAAPPRAV PHLLPSPGPERRCHAAGAALGPGAPGRGQPSAF LAAPKYRWH*GAAGRVREGPEGALGAPGPSGRS PN*PQKGASDQSA*APEDQVGAGR*QSYPGAATE *GVGPRPPNPGVVPARWHSGGQ*GTHFGELLLP GKSAGICRLLGVHLHLLWAQRLGGPDPREKLYP GAGAWGPSGSSHYFANPRSPPARPHLCPELAGIC THSEATRAPPGTAPHSPEAGCGNRDQDCGVGDC G*SLGGPEIPGLPAPAKPHTGSGPLAGHILPAP ECTSGTSGPGGLDPA*PGGDQPKPSCHPRKLPPL AQGTFAASIAP*QCPAGDWYFILWAYGGHGHSE LHLFS*LLRRCEHGPLHQHPGSRLLHSP*VGPQ PGPGP*FAWE*LPLSRSSPSQDLHHGGLHRLPTR PELQQLQPTGPGESPPGWNGQLPLRTAA*PTPY GCFLRKYVCGAGRAV*LWLPG*LRRSLL*FFDL PAEARCTVCI*RTLLSKLPAAPVWLAVSSYQRGL *LA*ILPRRQLPVSP*CQPRGWRALRWRASCVH ARALCLLCPAVPVTLGTWSPARCATLPPDS*YS GKCFWELWAQPQWQLCVLHP*RCHLWAAPVPDR* DPASAGLHPGSTLGDNRCEWD*AELQLGAPGPG Q*CGPAPPDSAWHSLWPWPGVYRPSMPACGSPG GTGMSKQMPWTWGL*QQQALLL*GGLGTP*LHHS AQSNQLPDHRAAPQPPGLIGPGDAWCQLLVPCP PAPATLPAQGTHLPVQGSPIWSL*TARTSAEGP AGTRH*G*AG*PTQSPYPPSAR*PGGEKPEVSGA SQAPTPKEATACRPPGPVPIG*PARPRGWNPAP SGTLQTSATASDSVLALPLTSPEVPLPPSRT*G FKRRACPLESPTMTEGARDWRCLKTPGTATRCQA TLCGPAGVVAAGAWGGAGGWTGLRKVRTACLCS VAINVTSWERSP

Sequence ADAM15.aAug05

CTGGGGTGAGCCGCGCACTGCCTCGCCTGCAGTCGGGAAAGCCTGCCCGCCCGACCTCTCCGAGCCAGGCCGCGCACAGGAGGCAGGGAGGCCGCGAAGC TACTAGGGAGGGGTCCGGACCTGGCGCCGGGTGAAGGCGCGCCGCCCAAGCCGGTCGGACCGGGCACCGGCTCCCACTCCGCACAGTTGCGGGGAAGCGG TAGCGCTGAGCAGCGCGGGCGTAGTGGGCGGTGTCCCCGCTCCCGAGGCACCCGGCGCGCAGCGGGGCGGGCTTTGCCGGGGGCGGAGCTTGGCTTGGGG CCGGGTGGGAGGGGGCGGGCCGGGGCGGGGCCTGGTGGCCGCGCGGCGCTGCTGGGTTCTCCGAGGCGACCTGGCCGCCGGCCGCTCCTCCGCGCGCTGT TCCGCACTTGCTGCCCTCGCCCGGCCCGGAGCGCCGCTGCCATGCGGCTGGCGCTGCTCTGGGCCCTGGGGCTCCTGGGCGCGGGCAGCCCTCTGCCTTC CTGGCCGCTCCCAAATATAGGTGGCACTGAGGAGCAGCAGGCAGAGTCAGAGAAGGCCCCGAGGGAGCCCTTGGAGCCCCAGGTCCTTCAGGACGATCTC CCAATTAGCCTCAAAAAGGTGCTTCAGACCAGTCTGCCTGAGCCCCTGAGGATCAAGTTGGAGCTGGACGGTGACAGTCATATCCTGGAGCTGCTACAGA ATAGGGAGTTGGTCCCAGGCCGCCCAACCCTGGTGTGGTACCAGCCCGATGGCACTCGGGTGGTCAGTGAGGGACACACTTTGGAGAACTGCTGCTACCA GGGAAGAGTGCGGGGATATGCAGGCTCCTGGGTGTCCATCTGCACCTGCTCTGGGCTCAGAGGCTTGGTGGTCCTGACCCCAGAGAGAAGCTATACCCTG GAGCAGGGGCCTGGGGACCTTCAGGGTCCTCCCATTATTTCGCGAATCCAAGATCTCCACCTGCCAGGCCACACCTGTGCCCTGAGCTGGCGGGAATCTG TACACACTCAGAAGCCACCAGAGCACCCCCTGGGACAGCGCCACATTCGCCGGAGGCGGGATGTGGTAACAGAGACCAAGACTGTGGAGTTGGTGATTGT GGCTGATCACTCGGAGGCCCAGAAATACCGGGACTTCCAGCACCTGCTAAACCGCACACTGGAAGTGGCCCTCTTGCTGGACACATTCTTCCGGCCCCTG AATGTACGAGTGGCACTAGTGGGCCTGGAGGCCTGGACCCAGCGTGACCTGGTGGAGATCAGCCCAAACCCAGCTGTCACCCTCGAAAACTTCCTCCACT GGCGCAGGGCACATTTGCTGCCTCGATTGCCCCATGACAGTGCCCAGCTGGTGACTGGTACTTCATTCTCTGGGCCTACGGTGGGCATGGCCATTCAGAA CTCCATCTGTTCTCCTGACTTCTCAGGAGGTGTGAACATGGACCACTCCACCAGCATCCTGGGAGTCGCCTCCTCCATAGCCCATGAGTTGGGCCACAGC CTGGGCCTGGACCATGATTTGCCTGGGAATAGCTGCCCCTGTCCAGGTCCAGCCCCAGCCAAGACCTGCATCATGGAGGCCTCCACAGACTTCCTACCAG GCCTGAACTTCAGCAACTGCAGCCGACGGGCCCTGGAGAAAGCCCTCCTGGATGGAATGGGCAGCTGCCTCTTCGAACGGCTGCCTAGCCTACCCCCTAT GGCTGCTTTCTGCGGAAATATGTTTGTGGAGCCGGGCGAGCAGTGTGACTGTGGCTTCCTGGATGACTGCGTCGATCCCTGCTGTGATTCTTTGACCTGC CAGCTGAGGCCAGGTGCACAGTGTGCATCTGACGGACCCTGTTGTCAAAATTGCCAGCTGCGCCCGTCTGGCTGGCAGTGTCGTCCTACCAGAGGGGATT GTGACTTGCCTGAATTCTGCCCAGGAGACAGCTCCCAGTGTCCCCCTGATGTCAGCCTAGGGGATGGCGAGCCCTGCGCTGGCGGGCAAGCTGTGTGCAT GCACGGGCGTTGTGCCTCCTATGCCCAGCAGTGCCAGTCACTTTGGGGACCTGGAGCCCAGCCCGCTGCGCCACTTTGCCTCCAGACAGCTAATACTCGG GGAAATGCTTTTGGGAGCTGTGGGCGCAACCCCAGTGGCAGTTATGTGTCCTGCACCCCTAGAGATGCCATTTGTGGGCAGCTCCAGTGCCAGACAGGTA GGACCCAGCCTCTGCTGGGCTCCATCCGGGATCTACTCTGGGAGACAATAGATGTGAATGGGACTGAGCTGAACTGCAGCTGGGTGCACCTGGACCTGGG CAGTGATGTGGCCCAGCCCCTCCTGACTCTGCCTGGCACAGCCTGTGGCCCTGGCCTGGTGTGTATAGACCATCGATGCCAGCGTGTGGATCTCCTGGGG GCACAGGAATGTCGAAGCAAATGCCATGGACATGGGGTCTGTGACAGCAACAGGCACTGCTACTGTGAGGAGGGCTGGGCACCCCCTGACTGCACCACTC AGCTCAAAGCAACCAGCTCCCTGACCACAGGGCTGCTCCTCAGCCTCCTGGTCTTATTGGTCCTGGTGATGCTTGGTGCCAGCTACTGGTACCGTGCCCG CCTGCACCAGCGACTCTGCCAGCTCAAGGGACCCACCTGCCAGTACAGGGCAGCCCAATCTGGTCCCTCTGAACGGCCAGGACCTCCGCAGAGGGCCCTG CTGGCACGAGGCACTAAGCAGGCTAGTGCTCTCAGCTTCCCGGCCCCCCCTTCCAGGCCGCTGCCGCCTGACCCTGTGTCCAAGAGACTCCAGGCTGAGC TGGCTGACCGACCCAATCCCCCTACCCGCCCTCTGCCCGCTGACCCGGTGGTGAGAAGCCCGAAGTCTCAGGGGCCAGCCAAGCCCCCACCCCCAAGGAA GCCACTGCCTGCCGACCCCCAGGGCCGGTGCCCATCGGGTGACCTGCCCGGCCCAGGGGCTGGAATCCCGCCCCTAGTGGTACCCTCCAGACCAGCGCCA CCGCCTCCGACAGTGTCCTCGCTCTACCTCTGACCTCTCCGGAGGTTCCGCTGCCTCCAAGCCGGACTTAGGGCTTCAAGAGGCGGGCGTGCCCTCTGGA GTCCCCTACCATGACTGAAGGCGCCAGAGACTGGCGGTGTCTTAAGACTCCGGGCACCGCCACGCGCTGTCAAGCAACACTCTGCGGACCTGCCGGCGTA GTTGCAGCGGGGGCTTGGGGAGGGGCTGGGGGTTGGACGGGATTGAGGAAGGTCCGCACAGCCTGTCTCTGCTCAGTTGCAATAAACGTGACATCTTGGG AGCGTTCCCCAGA

ADAM15.F7 (forward primer)
ADAM15.R2 (reverse primer)
Single exon skipping

Frame 0

LG*AAHCLACSRESLPARPLRARPRTGGREAAK LLGRGPDLAPGEGAPPKPVGPGTGSHSAQLRGSG SAEQRGRSGRCPRSRGTRRAAGRALPGAELGLG PGGRGRAGAGPGGRAALLGSPRRPGRRPLLRAL FRTCCPRPARSAAAMRLALLWALGLLGAGSPLPS WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDL PISLKKVLQTSLPEPLRIKLELDGDSHILELLQ NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTL EQGPGDLQGPPIISRIQDLHLPGHTCALSWRES VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIV ADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPL NVRVALVGLEAWTQRDLVEISPNPAVTLENFLH WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQN SICSPDFSGGVNMDHSTSILGVASSIAHELGHS LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLP GLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTC QLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCM HGRCASYAQQCQSLWGPGAQPAAPLCLQTANTR GNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTG RTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLG SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG AQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTT QLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRAL LARGTKQASALSFPAPPSRPLPPDPVSKRLQAE LADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRK PLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAP PPPTVSSLYL*PLRRFRCLQAGLRASRGGRALW SPLP*LKAPETGGVLRLRAPPRAVKQHSADLPA* LQRGLGEGLGVGRD*GRSAQPVSAQLQ*T*HLG SVPQ

Frame 1

WGEPRTASPAVGKACPPDLSEPGRAQEAGRPRS Y*GGVRTWRRVKARRPSRSDRAPAPTPHSCGEA VALSSAGVVGGVPAPEAPGAQRGGLCRGRSLAWG RVGGGGPGRGLVAARRCWVLRGDLAAGRSSARC SALAALARPGAPLPCGWRCSGPWGSWARAALCL PGRSQI*VALRSSRQSQRRPRGSPWSPRSFRTIS QLASKRCFRPVCLSP*GSSWSWTVTVISWSCYR IGSWSQAAQPWCGTSPMALGWSVRDTLWRTAAT REECGDMQAPGCPSAPALGSEAWWS*PQREAIPW SRGLGTFRVLPLFRESKISTCQATPVP*AGGNL YTLRSHQSTPWDSATFAGGGMW*QRPRLWSW*L WLITRRPRNTGTSSTC*TAHWKWPSCWTHSSGP* MYEWH*WAWRPGPSVTWWRSAQTQLSPSKTSST GAGHICCLDCPMTVPSW*LVLHSLGLRWAWPFR TPSVLLTSQEV*TWTTPPASWESPPP*PMSWATA WAWTMICLGIAAPVQVQPQPRPASWRPPQTSYQ A*TSATAADGPWRKPSWMEWAAASSNGCLAYPL WLLSAEICLWSRASSVTVASWMTASIPAVIL*PA S*GQVHSVHLTDPVVKIASCARLAGSVVLPEGI VTCLNSAQETAPSVPLMSA*GMASPALAGKLCA CTGVVPPMPSSASHFGDLEPSPLRHFASRQLILG EMLLGAVGATPVAVMCPAPLEMPFVGSSSARQV GPSLCWAPSGIYSGRQ*M*MGLS*TAAGCTWTW AVMWPSPS*LCLAQPVALAWCV*TIDASVWISWG HRNVEANAMDMGSVTATGTATVRRAGHPLTAPL SSKQPAP*PQGCSSASWSYWSW*CLVPATGTVP ACTSDSASSRDPPASTGQPNLVPLNGQDLRRGPC WHEALSRLVLSASRPPLPGRCRLTLCPRDSRLS WLTDPIPLPALCPLTRW*EARSLRGQPSPHPQG SHCLPTPRAGAHRVTCPAQGLESRP*WYPPDQRH RLRQCPRSTSDLSGGSAASKPDLGLQEAGVPSG VPYHD*RRQRLAVS*DSGHRHALSSNTLRTCRR SCSGGLGRGWGLDGIEEGPHSLSLLSCNKRDILG AFPR

Frame 2

GVSRALPRLQSGKPARPTSPSQAAHRRQGGREA TREGSGPGAG*RRAAQAGRTGHRLPLRTVAGKR *R*AARA*WAVSPLPRHPARSGAGFAGGGAWLG AGWEGAGRGGAWWPRGAAGFSEATWPPAAPPRAV PHLLPSPGPERRCHAAGAALGPGAPGRGQPSAF LAAPKYRWH*GAAGRVREGPEGALGAPGPSGRS PN*PQKGASDQSA*APEDQVGAGR*QSYPGAATE *GVGPRPPNPGVVPARWHSGGQ*GTHFGELLLP GKSAGICRLLGVHLHLLWAQRLGGPDPREKLYP GAGAWGPSGSSHYFANPRSPPARPHLCPELAGIC THSEATRAPPGTAPHSPEAGCGNRDQDCGVGDC G*SLGGPEIPGLPAPAKPHTGSGPLAGHILPAP ECTSGTSGPGGLDPA*PGGDQPKPSCHPRKLPPL AQGTFAASIAP*QCPAGDWYFILWAYGGHGHSE LHLFS*LLRRCEHGPLHQHPGSRLLHSP*VGPQ PGPGP*FAWE*LPLSRSSPSQDLHHGGLHRLPTR PELQQLQPTGPGESPPGWNGQLPLRTAA*PTPY GCFLRKYVCGAGRAV*LWLPG*LRRSLL*FFDL PAEARCTVCI*RTLLSKLPAAPVWLAVSSYQRGL *LA*ILPRRQLPVSP*CQPRGWRALRWRASCVH ARALCLLCPAVPVTLGTWSPARCATLPPDS*YS GKCFWELWAQPQWQLCVLHP*RCHLWAAPVPDR* DPASAGLHPGSTLGDNRCEWD*AELQLGAPGPG Q*CGPAPPDSAWHSLWPWPGVYRPSMPACGSPG GTGMSKQMPWTWGL*QQQALLL*GGLGTP*LHHS AQSNQLPDHRAAPQPPGLIGPGDAWCQLLVPCP PAPATLPAQGTHLPVQGSPIWSL*TARTSAEGP AGTRH*AG*CSQLPGPPFQAAAA*PCVQETPG*A G*PTQSPYPPSAR*PGGEKPEVSGASQAPTPKE ATACRPPGPVPIG*PARPRGWNPAPSGTLQTSA TASDSVLALPLTSPEVPLPPSRT*GFKRRACPLE SPTMTEGARDWRCLKTPGTATRCQATLCGPAGV VAAGAWGGAGGWTGLRKVRTACLCSVAINVTSW ERSP

Sequence ADAM15.fAug05

CTGGGGTGAGCCGCGCACTGCCTCGCCTGCAGTCGGGAAAGCCTGCCCGCCCGACCTCTCCGAGCCAGGCCGCGCACAGGAGGCAGGGAGGCCGCGAAGC TACTAGGGAGGGGTCCGGACCTGGCGCCGGGTGAAGGCGCGCCGCCCAAGCCGGTCGGACCGGGCACCGGCTCCCACTCCGCACAGTTGCGGGGAAGCGG TAGCGCTGAGCAGCGCGGGCGTAGTGGGCGGTGTCCCCGCTCCCGAGGCACCCGGCGCGCAGCGGGGCGGGCTTTGCCGGGGGCGGAGCTTGGCTTGGGG CCGGGTGGGAGGGGGCGGGCCGGGGCGGGGCCTGGTGGCCGCGCGGCGCTGCTGGGTTCTCCGAGGCGACCTGGCCGCCGGCCGCTCCTCCGCGCGCTGT TCCGCACTTGCTGCCCTCGCCCGGCCCGGAGCGCCGCTGCCATGCGGCTGGCGCTGCTCTGGGCCCTGGGGCTCCTGGGCGCGGGCAGCCCTCTGCCTTC CTGGCCGCTCCCAAATATAGGTGGCACTGAGGAGCAGCAGGCAGAGTCAGAGAAGGCCCCGAGGGAGCCCTTGGAGCCCCAGGTCCTTCAGGACGATCTC CCAATTAGCCTCAAAAAGGTGCTTCAGACCAGTCTGCCTGAGCCCCTGAGGATCAAGTTGGAGCTGGACGGTGACAGTCATATCCTGGAGCTGCTACAGA ATAGGGAGTTGGTCCCAGGCCGCCCAACCCTGGTGTGGTACCAGCCCGATGGCACTCGGGTGGTCAGTGAGGGACACACTTTGGAGAACTGCTGCTACCA GGGAAGAGTGCGGGGATATGCAGGCTCCTGGGTGTCCATCTGCACCTGCTCTGGGCTCAGAGGCTTGGTGGTCCTGACCCCAGAGAGAAGCTATACCCTG GAGCAGGGGCCTGGGGACCTTCAGGGTCCTCCCATTATTTCGCGAATCCAAGATCTCCACCTGCCAGGCCACACCTGTGCCCTGAGCTGGCGGGAATCTG TACACACTCAGAAGCCACCAGAGCACCCCCTGGGACAGCGCCACATTCGCCGGAGGCGGGATGTGGTAACAGAGACCAAGACTGTGGAGTTGGTGATTGT GGCTGATCACTCGGAGGCCCAGAAATACCGGGACTTCCAGCACCTGCTAAACCGCACACTGGAAGTGGCCCTCTTGCTGGACACATTCTTCCGGCCCCTG AATGTACGAGTGGCACTAGTGGGCCTGGAGGCCTGGACCCAGCGTGACCTGGTGGAGATCAGCCCAAACCCAGCTGTCACCCTCGAAAACTTCCTCCACT GGCGCAGGGCACATTTGCTGCCTCGATTGCCCCATGACAGTGCCCAGCTGGTGACTGGTACTTCATTCTCTGGGCCTACGGTGGGCATGGCCATTCAGAA CTCCATCTGTTCTCCTGACTTCTCAGGAGGTGTGAACATGGACCACTCCACCAGCATCCTGGGAGTCGCCTCCTCCATAGCCCATGAGTTGGGCCACAGC CTGGGCCTGGACCATGATTTGCCTGGGAATAGCTGCCCCTGTCCAGGTCCAGCCCCAGCCAAGACCTGCATCATGGAGGCCTCCACAGACTTCCTACCAG GCCTGAACTTCAGCAACTGCAGCCGACGGGCCCTGGAGAAAGCCCTCCTGGATGGAATGGGCAGCTGCCTCTTCGAACGGCTGCCTAGCCTACCCCCTAT GGCTGCTTTCTGCGGAAATATGTTTGTGGAGCCGGGCGAGCAGTGTGACTGTGGCTTCCTGGATGACTGCGTCGATCCCTGCTGTGATTCTTTGACCTGC CAGCTGAGGCCAGGTGCACAGTGTGCATCTGACGGACCCTGTTGTCAAAATTGCCAGCTGCGCCCGTCTGGCTGGCAGTGTCGTCCTACCAGAGGGGATT GTGACTTGCCTGAATTCTGCCCAGGAGACAGCTCCCAGTGTCCCCCTGATGTCAGCCTAGGGGATGGCGAGCCCTGCGCTGGCGGGCAAGCTGTGTGCAT GCACGGGCGTTGTGCCTCCTATGCCCAGCAGTGCCAGTCACTTTGGGGACCTGGAGCCCAGCCCGCTGCGCCACTTTGCCTCCAGACAGCTAATACTCGG GGAAATGCTTTTGGGAGCTGTGGGCGCAACCCCAGTGGCAGTTATGTGTCCTGCACCCCTAGAGATGCCATTTGTGGGCAGCTCCAGTGCCAGACAGGTA GGACCCAGCCTCTGCTGGGCTCCATCCGGGATCTACTCTGGGAGACAATAGATGTGAATGGGACTGAGCTGAACTGCAGCTGGGTGCACCTGGACCTGGG CAGTGATGTGGCCCAGCCCCTCCTGACTCTGCCTGGCACAGCCTGTGGCCCTGGCCTGGTGTGTATAGACCATCGATGCCAGCGTGTGGATCTCCTGGGG GCACAGGAATGTCGAAGCAAATGCCATGGACATGGGGTCTGTGACAGCAACAGGCACTGCTACTGTGAGGAGGGCTGGGCACCCCCTGACTGCACCACTC AGCTCAAAGCAACCAGCTCCCTGACCACAGGGCTGCTCCTCAGCCTCCTGGTCTTATTGGTCCTGGTGATGCTTGGTGCCAGCTACTGGTACCGTGCCCG CCTGCACCAGCGACTCTGCCAGCTCAAGGGACCCACCTGCCAGTACAGGGCAGCCCAATCTGGTCCCTCTGAACGGCCAGGACCTCCGCAGAGGGCCCTG CTGGCACGAGGCACTAAGCAGGCTAGTGCTCTCAGCTTCCCGGCCCCCCCTTCCAGGCCGCTGCCGCCTGACCCTGTGTCCAAGAGACTCCAGGCTGAGC TGGCTGACCGACCCAATCCCCCTACCCGCCCTCTGCCCGCTGACCCGGTGGTGAGAAGCCCGAAGGTAACGGTGGGGGGAGAGAAGGGCACGGCCTCTCC CCCCACCTAGGGCTGTGGTGCTGGTAGCCATGACGGTGGTGGCCGTGGCGAGATGCCCCCTCAGTGCATGAGGGCACATATCCCGGTGGTGCCTTTAATG GTGACAGTCTCAGGGGCCAGCCAAGCCCCCACCCCCAAGGAAGCCACTGCCTGCCGACCCCCAGGGCCGGTGCCCATCGGGTGACCTGCCCGGCCCAGGG GCTGGAATCCCGCCCCTAGTGGTACCCTCCAGACCAGCGCCACCGCCTCCGACAGTGTCCTCGCTCTACCTCTGACCTCTCCGGAGGTTCCGCTGCCTCC AAGCCGGACTTAGGGCTTCAAGAGGCGGGCGTGCCCTCTGGAGTCCCCTACCATGACTGAAGGCGCCAGAGACTGGCGGTGTCTTAAGACTCCGGGCACC GCCACGCGCTGTCAAGCAACACTCTGCGGACCTGCCGGCGTAGTTGCAGCGGGGGCTTGGGGAGGGGCTGGGGGTTGGACGGGATTGAGGAAGGTCCGCA CAGCCTGTCTCTGCTCAGTTGCAATAAACGTGACATCTTGGGAGCGTTCCCCAGA

ADAM15.F7 (forward primer)
ADAM15.R2 (reverse primer)
Single exon skipping

Frame 0

LG*AAHCLACSRESLPARPLRARPRTGGREAAK LLGRGPDLAPGEGAPPKPVGPGTGSHSAQLRGSG SAEQRGRSGRCPRSRGTRRAAGRALPGAELGLG PGGRGRAGAGPGGRAALLGSPRRPGRRPLLRAL FRTCCPRPARSAAAMRLALLWALGLLGAGSPLPS WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDL PISLKKVLQTSLPEPLRIKLELDGDSHILELLQ NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTL EQGPGDLQGPPIISRIQDLHLPGHTCALSWRES VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIV ADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPL NVRVALVGLEAWTQRDLVEISPNPAVTLENFLH WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQN SICSPDFSGGVNMDHSTSILGVASSIAHELGHS LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLP GLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTC QLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCM HGRCASYAQQCQSLWGPGAQPAAPLCLQTANTR GNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTG RTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLG SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG AQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTT QLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRAL LARGTKQASALSFPAPPSRPLPPDPVSKRLQAE LADRPNPPTRPLPADPVVRSPKVTVGGEKGTASP PT*GCGAGSHDGGGRGEMPPQCMRAHIPVVPLM VTVSGASQAPTPKEATACRPPGPVPIG*PARPR GWNPAPSGTLQTSATASDSVLALPLTSPEVPLPP SRT*GFKRRACPLESPTMTEGARDWRCLKTPGT ATRCQATLCGPAGVVAAGAWGGAGGWTGLRKVR TACLCSVAINVTSWERSP

Frame 1

WGEPRTASPAVGKACPPDLSEPGRAQEAGRPRS Y*GGVRTWRRVKARRPSRSDRAPAPTPHSCGEA VALSSAGVVGGVPAPEAPGAQRGGLCRGRSLAWG RVGGGGPGRGLVAARRCWVLRGDLAAGRSSARC SALAALARPGAPLPCGWRCSGPWGSWARAALCL PGRSQI*VALRSSRQSQRRPRGSPWSPRSFRTIS QLASKRCFRPVCLSP*GSSWSWTVTVISWSCYR IGSWSQAAQPWCGTSPMALGWSVRDTLWRTAAT REECGDMQAPGCPSAPALGSEAWWS*PQREAIPW SRGLGTFRVLPLFRESKISTCQATPVP*AGGNL YTLRSHQSTPWDSATFAGGGMW*QRPRLWSW*L WLITRRPRNTGTSSTC*TAHWKWPSCWTHSSGP* MYEWH*WAWRPGPSVTWWRSAQTQLSPSKTSST GAGHICCLDCPMTVPSW*LVLHSLGLRWAWPFR TPSVLLTSQEV*TWTTPPASWESPPP*PMSWATA WAWTMICLGIAAPVQVQPQPRPASWRPPQTSYQ A*TSATAADGPWRKPSWMEWAAASSNGCLAYPL WLLSAEICLWSRASSVTVASWMTASIPAVIL*PA S*GQVHSVHLTDPVVKIASCARLAGSVVLPEGI VTCLNSAQETAPSVPLMSA*GMASPALAGKLCA CTGVVPPMPSSASHFGDLEPSPLRHFASRQLILG EMLLGAVGATPVAVMCPAPLEMPFVGSSSARQV GPSLCWAPSGIYSGRQ*M*MGLS*TAAGCTWTW AVMWPSPS*LCLAQPVALAWCV*TIDASVWISWG HRNVEANAMDMGSVTATGTATVRRAGHPLTAPL SSKQPAP*PQGCSSASWSYWSW*CLVPATGTVP ACTSDSASSRDPPASTGQPNLVPLNGQDLRRGPC WHEALSRLVLSASRPPLPGRCRLTLCPRDSRLS WLTDPIPLPALCPLTRW*EARR*RWGERRARPL PPPRAVVLVAMTVVAVARCPLSA*GHISRWCL*W *QSQGPAKPPPPRKPLPADPQGRCPSGDLPGPG AGIPPLVVPSRPAPPPPTVSSLYL*PLRRFRCL QAGLRASRGGRALWSPLP*LKAPETGGVLRLRAP PRAVKQHSADLPA*LQRGLGEGLGVGRD*GRSA QPVSAQLQ*T*HLGSVPQ

Frame 2

GVSRALPRLQSGKPARPTSPSQAAHRRQGGREA TREGSGPGAG*RRAAQAGRTGHRLPLRTVAGKR *R*AARA*WAVSPLPRHPARSGAGFAGGGAWLG AGWEGAGRGGAWWPRGAAGFSEATWPPAAPPRAV PHLLPSPGPERRCHAAGAALGPGAPGRGQPSAF LAAPKYRWH*GAAGRVREGPEGALGAPGPSGRS PN*PQKGASDQSA*APEDQVGAGR*QSYPGAATE *GVGPRPPNPGVVPARWHSGGQ*GTHFGELLLP GKSAGICRLLGVHLHLLWAQRLGGPDPREKLYP GAGAWGPSGSSHYFANPRSPPARPHLCPELAGIC THSEATRAPPGTAPHSPEAGCGNRDQDCGVGDC G*SLGGPEIPGLPAPAKPHTGSGPLAGHILPAP ECTSGTSGPGGLDPA*PGGDQPKPSCHPRKLPPL AQGTFAASIAP*QCPAGDWYFILWAYGGHGHSE LHLFS*LLRRCEHGPLHQHPGSRLLHSP*VGPQ PGPGP*FAWE*LPLSRSSPSQDLHHGGLHRLPTR PELQQLQPTGPGESPPGWNGQLPLRTAA*PTPY GCFLRKYVCGAGRAV*LWLPG*LRRSLL*FFDL PAEARCTVCI*RTLLSKLPAAPVWLAVSSYQRGL *LA*ILPRRQLPVSP*CQPRGWRALRWRASCVH ARALCLLCPAVPVTLGTWSPARCATLPPDS*YS GKCFWELWAQPQWQLCVLHP*RCHLWAAPVPDR* DPASAGLHPGSTLGDNRCEWD*AELQLGAPGPG Q*CGPAPPDSAWHSLWPWPGVYRPSMPACGSPG GTGMSKQMPWTWGL*QQQALLL*GGLGTP*LHHS AQSNQLPDHRAAPQPPGLIGPGDAWCQLLVPCP PAPATLPAQGTHLPVQGSPIWSL*TARTSAEGP AGTRH*AG*CSQLPGPPFQAAAA*PCVQETPG*A G*PTQSPYPPSAR*PGGEKPEGNGGGREGHGLS PHLGLWCW*P*RWWPWRDAPSVHEGTYPGGAFN GDSLRGQPSPHPQGSHCLPTPRAGAHRVTCPAQG LESRP*WYPPDQRHRLRQCPRSTSDLSGGSAAS KPDLGLQEAGVPSGVPYHD*RRQRLAVS*DSGH RHALSSNTLRTCRRSCSGGLGRGWGLDGIEEGPH SLSLLSCNKRDILGAFPR