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Sequences

Sequence NM_023925

GTCGGTGCCTGCAGGGCTCTCCGTGGCCGCTCGGGAGAGGTGCTCTTCGCTCAGGCTCCCCCGGAGACTTGAGGGGGTGCGCGCTGGCGTGCATGGGGCC TGTTCTGTCCTTGGTTTGGGGATGCTCCTAAGGGGGGAGAAAGGGATACCTCGGGTGCTTGGAGGTCGAGAGACGGATACGTAAGTGCGCAAGGGCCACT GATTAGGGCACGGGAAGGGCTCGCTAGAATGAGCTCTTAAACTGGTTGGGTGTAAGCGGTTTTGGGCTAGTCTAAACCAAACAACTGAGAATAAACGCGG GGTTCCTGCAGGTTGAGAGAGTACCTGTCTGCAAATGTCCAGTAGTGATGGATTGCCTTGTAGGCCCCAGAGCAATCGGGGAAGTTAGCATTCTTGTTCA AGAAGCTGCTGGTTCACTTAGAGCTATAAAAGAATGTTGTGAGTTTGGATTTTCTTCCAAACGTTCAGGATTGAGGTTAGGGCTGGTGGTGAGGGATCAT GTAAAGAGGTTTGAGTGGCTCAGCCTTAGGTCCCGGTGTGGAAAGCTTATTCTTTTGGTGTCATCACGTGGCCGTGGGAATTATTTAGAATGTGATCTGC CCTCATGAGAAGAAAGGAGCTCTGAAGCCGTTGCAGTTCTTCCTCCCTATGTGGAAAATCGAATTTCTGGAAACATCCTCCGTATTGGGAGATTTTGCCT ATGTAAAGGCTATCCTTATTGGCTAGCGGCACTAATTACTTTAAAAGTAGGATGGAAGTACAAGTATCTCAAGCATCATTGGGTTTCGAGCTCACTTCTG TGGAAAAGAGTTTAAGGGAGTGGTCTAGACTTTCCAGGGAAGTTATTGCCTGGCTGTGTCCCTCTAGTCCTAATTTTATACTTAACTTTCCCCCACCTCC TTCAGCCTCATCTGTTTCAATGGTGCAACTCTTTTCATCCCCTTTTGGTTACCAGTCACCTTCAGGCCATTCAGAGGAGGAAAGAGAGGGGAATATGAAG TCAGCCAAGCCCCAAGTGAACCACAGTCAGCATGGGGAAAGCCAGCGGGCCTTGAGCCCCCTGCAGTCTACTCTGAGTTCTGCTGCATCTCCTTCCCAAG CGTATGAGACCTATATTGAAAATGGACTCATATGCCTTAAACACAAAATTAGAAACATCGAGAAAAAGAAGCTCAAACTGGAGGATTATAAGGATCGCCT GAAAAGTGGAGAGCATCTTAATCCAGACCAGTTGGAAGCTGTAGAGAAATATGAAGAAGTGCTACATAATTTGGAATTTGCCAAGGAGCTTCAAAAAACC TTTTCTGGGTTGAGCCTAGATCTACTAAAAGCGCAAAAGAAGGCCCAGAGAAGGGAGCACATGCTAAAACTTGAGGCTGAGAAGAAAAAGCTTCGAACTA TACTTCAAGTTCAGTATGTATTGCAGAACTTGACACAGGAGCACGTACAAAAAGACTTCAAAGGGGGTTTGAATGGTGCAGTGTATTTGCCTTCAAAAGA ACTTGACTACCTCATTAAGTTTTCAAAACTGACCTGCCCTGAAAGAAATGAAAGTCTGAGTGTTGAAGACCAGATGGAGCAGTCATCCTTGTACTTTTGG GACCTTTTGGAAGGTAGTGAGAAAGCAGTGGTAGGAACGACATACAAACACTTGAAGGATCTACTGTCTAAATTGCTGAACTCAGGCTATTTTGAAAGTA TCCCAGTTCCCAAAAATGCCAAGGAAAAGGAAGTACCACTGGAGGAAGAAATGCTAATACAATCAGAGAAAAAAACACAATTATCGAAGACTGAATCTGT CAAAGAGTCAGAGTCTCTAATGGAATTTGCCCAGCCAGAGATACAACCACAAGAGTTTCTTAACAGACGCTATATGACAGAAGTAGATTATTCAAACAAA CAAGGCGAAGAGCAACCTTGGGAAGCAGATTATGCTAGAAAACCAAATCTCCCAAAACGTTGGGATATGCTTACTGAACCAGATGGTCAAGAGAAGAAAC AGGAGTCCTTTAAGTCCTGGGAGGCTTCTGGTAAGCACCAGGAGGTATCCAAGCCTGCAGTTTCCTTAGAACAGAGGAAACAAGACACCTCAAAACTCAG GTCTACTCTGCCGGAAGAGCAGAAGAAGCAGGAGATCTCCAAATCCAAGCCATCTCCTAGCCAGTGGAAGCAAGATACACCTAAATCCAAAGCAGGGTAT GTTCAAGAGGAACAAAAGAAACAGGAGACACCAAAGCTGTGGCCAGTTCAGCTGCAGAAAGAACAAGATCCAAAGAAGCAAACTCCAAAGTCTTGGACAC CTTCCATGCAGAGCGAACAGAACACCACCAAGTCATGGACCACTCCCATGTGTGAAGAACAGGATTCAAAACAGCCAGAGACTCCAAAATCCTGGGAAAA CAATGTTGAGAGTCAAAAACACTCTTTAACATCACAGTCACAGATTTCTCCAAAGTCCTGGGGAGTAGCTACAGCAAGCCTCATACCAAATGACCAGCTG CTGCCCAGGAAGTTGAACACAGAACCCAAAGATGTGCCTAAGCCTGTGCATCAGCCTGTAGGTTCTTCCTCTACCCTTCCGAAGGATCCAGTATTGAGGA AAGAAAAACTGCAGGATCTGATGACTCAGATTCAAGGAACTTGTAACTTTATGCAAGAGTCTGTTCTTGACTTTGACAAACCTTCAAGTGCAATTCCAAC GTCACAACCGCCTTCAGCTACTCCAGGTAGCCCCGTAGCATCTAAAGAACAAAATCTGTCCAGTCAAAGTGATTTTCTTCAAGAGCCGTTACAGGCTACT TCTTCTCCAGTTACTTGTAGCTCAAATGCTTGCTTGGTTACTACCGATCAGGCTTCTTCTGGATCTGAAACAGAGTTTATGACCTCAGAGACTCCTGAGG TATTTAACGTTAATGCACCTCTGCCTCCACGAAAAGAACAAGAAATAAAAGAATCCCCTTATTCACCTGGCTACAATCAAAGTTTTACCACAGCAAGTAC ACAAACACCACCCCAGTGCCAACTGCCATCTATACATGTAGAACAAACTGTCCATTCTCAAGAGACTGCAAATTATCATCCTGATGGAACTATTCAAGTA AGCAATGGTAGCCTTGCCTTTTACCCAGCACAGACGAATGTGTTTCCCAGACCTACTCAGCCATTTGTCAATAGCCGGGGATCTGTTAGAGGATGTACTC GTGGTGGGAGATTAATAACCAATTCCTATCGGTCCCCTGGTGGTTATAAAGGTTTTGATACTTATAGAGGACTCCCTTCAATTTCCAATGGAAATTATAG CCAGCTGCAGTTCCAAGCTAGAGAGTATTCTGGAGCACCTTATTCCCAAAGGGATAATTTCCAGCAGTGTTATAAGCGAGGAGGGACATCTGGTGGTCCA CGAGCAAATTCGAGAGCAGGGTGGAGTGATTCTTCTCAGGTGAGCAGCCCAGAAAGAGACAACGAAACCTTTAACAGTGGTGACTCTGGACAAGGAGACT CCCGTAGCATGACCCCTGTGGATGTGCCAGTGACAAATCCAGCAGCCACCATACTGCCAGTACACGTCTACCCTCTGCCTCAGCAGATGCGAGTTGCCTT CTCAGCAGCCAGAACCTCTAATCTGGCCCCTGGAACTTTAGACCAACCTATTGTGTTTGATCTTCTTCTGAACAACTTAGGAGAAACTTTTGATCTTCAG CTTGGTAGATTTAATTGCCCAGTGAATGGCACTTACGTTTTCATTTTTCACATGCTAAAGCTGGCAGTGAATGTGCCACTGTATGTCAACCTCATGAAGA ATGAAGAGGTCTTGGTATCAGCCTATGCCAATGATGGTGCTCCAGACCATGAAACTGCTAGCAATCATGCAATTCTTCAGCTCTTCCAGGGAGACCAGAT ATGGTTACGTCTGCACAGGGGAGCAATTTATGGAAGTAGCTGGAAATATTCTACGTTTTCAGGCTATCTTCTTTATCAAGATTGAAAGTCAGTACAGTAT TGACAATAAAAGGATGGTGTTCTAATTAGTGGGATTGAAGGAAAAGTAGTCTTTGCCCTCATGACTGATTGGTTTAGGAAAATGTTTTTGTTCCTAGAGG GAGGAGGTCCTTACTTTTTTGTTTTCCTTCCTGAGGTGAAAAATCAAGCTGAATGACAATTAGCACTAATCTGGCACTTTATAAATTGTGATGTAGCCTC GCTAGTCAAGCTGTGAATGTATATTGTTTGCACTTAATCCTTAACTGTATTAACGTTCAGCTTACTAAACTGACTGCCTCAAGTCCAGGCAAGTTACAAT GCCTTGTTGTGCCTCAATAAAAAAGTTACATGCAC

refseq_C1QDC1.F3 (forward primer)
refseq_C1QDC1.R3 (reverse primer)
Single exon skipping

Frame 0

VGACRALRGRSGEVLFAQAPPET*GGARWRAWG LFCPWFGDAPKGGERDTSGAWRSRDGYVSAQGPL IRAREGLARMSS*TGWV*AVLG*SKPNN*E*TR GSCRLREYLSANVQ**WIAL*APEQSGKLAFLF KKLLVHLEL*KNVVSLDFLPNVQD*G*GWW*GIM *RGLSGSALGPGVESLFFWCHHVAVGII*NVIC PHEKKGALKPLQFFLPMWKIEFLETSSVLGDFA YVKAILIG*RH*LL*K*DGSTSISSIIGFRAHFC GKEFKGVV*TFQGSYCLAVSL*S*FYT*LSPTS FSLICFNGATLFIPFWLPVTFRPFRGGKRGEYE VSQAPSEPQSAWGKPAGLEPPAVYSEFCCISFPS V*DLY*KWTHMP*TQN*KHREKEAQTGGL*GSP EKWRAS*SRPVGSCREI*RSAT*FGICQGASKN LFWVEPRSTKSAKEGPEKGAHAKT*G*EEKASNY TSSSVCIAELDTGARTKRLQRGFEWCSVFAFKR T*LPH*VFKTDLP*KK*KSEC*RPDGAVILVLL GPFGR**ESSGRNDIQTLEGSTV*IAELRLF*KY PSSQKCQGKGSTTGGRNANTIREKNTIIED*IC QRVRVSNGICPARDTTTRVS*QTLYDRSRLFKQ TRRRATLGSRLC*KTKSPKTLGYAY*TRWSREET GVL*VLGGFW*APGGIQACSFLRTEETRHLKTQ VYSAGRAEEAGDLQIQAIS*PVEARYT*IQSRV CSRGTKETGDTKAVASSAAERTRSKEANSKVLDT FHAERTEHHQVMDHSHV*RTGFKTARDSKILGK QC*ESKTLFNITVTDFSKVLGSSYSKPHTK*PA AAQEVEHRTQRCA*ACASACRFFLYPSEGSSIEE RKTAGSDDSDSRNL*LYARVCS*L*QTFKCNSN VTTAFSYSR*PRSI*RTKSVQSK*FSSRAVTGY FFSSYL*LKCLLGYYRSGFFWI*NRVYDLRDS*G I*R*CTSASTKRTRNKRIPLFTWLQSKFYHSKY TNTTPVPTAIYTCRTNCPFSRDCKLSS*WNYSS KQW*PCLLPSTDECVSQTYSAICQ*PGIC*RMYS WWEINNQFLSVPWWL*RF*YL*RTPFNFQWKL* PAAVPS*RVFWSTLFPKG*FPAVL*ARRDIWWS TSKFESRVE*FFSGEQPRKRQRNL*QW*LWTRRL P*HDPCGCASDKSSSHHTASTRLPSASADASCL LSSQNL*SGPWNFRPTYCV*SSSEQLRRNF*SS AW*I*LPSEWHLRFHFSHAKAGSECATVCQPHEE *RGLGISLCQ*WCSRP*NC*QSCNSSALPGRPD MVTSAQGSNLWK*LEIFYVFRLSSLSRLKVSTV LTIKGWCSN*WD*RKSSLCPHD*LV*ENVFVPRG RRSLLFCFPS*GEKSS*MTISTNLALYKL*CSL ASQAVNVYCLHLILNCINVQLTKLTASSPGKLQ CLVVPQ*KSYMH

Frame 1

SVPAGLSVAARERCSSLRLPRRLEGVRAGVHGA CSVLGLGMLLRGEKGIPRVLGGRETDT*VRKGH *LGHGKGSLE*ALKLVGCKRFWASLNQTTENKRG VPAG*ESTCLQMSSSDGLPCRPQSNRGS*HSCS RSCWFT*SYKRML*VWIFFQTFRIEVRAGGEGS CKEV*VAQP*VPVWKAYSFGVITWPWELFRM*SA LMRRKEL*SRCSSSSLCGKSNFWKHPPYWEILP M*RLSLLASGTNYFKSRMEVQVSQASLGFELTS VEKSLREWSRLSREVIAWLCPSSPNFILNFPPPP SASSVSMVQLFSSPFGYQSPSGHSEEEREGNMK SAKPQVNHSQHGESQRALSPLQSTLSSAASPSQ AYETYIENGLICLKHKIRNIEKKKLKLEDYKDRL KSGEHLNPDQLEAVEKYEEVLHNLEFAKELQKT FSGLSLDLLKAQKKAQRREHMLKLEAEKKKLRT ILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKE LDYLIKFSKLTCPERNESLSVEDQMEQSSLYFW DLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFES IPVPKNAKEKEVPLEEEMLIQSEKKTQLSKTESV KESESLMEFAQPEIQPQEFLNRRYMTEVDYSNK QGEEQPWEADYARKPNLPKRWDMLTEPDGQEKK QESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLR STLPEEQKKQEISKSKPSPSQWKQDTPKSKAGY VQEEQKKQETPKLWPVQLQKEQDPKKQTPKSWT PSMQSEQNTTKSWTTPMCEEQDSKQPETPKSWEN NVESQKHSLTSQSQISPKSWGVATASLIPNDQL LPRKLNTEPKDVPKPVHQPVGSSSTLPKDPVLR KEKLQDLMTQIQGTCNFMQESVLDFDKPSSAIPT SQPPSATPGSPVASKEQNLSSQSDFLQEPLQAT SSPVTCSSNACLVTTDQASSGSETEFMTSETPE VFNVNAPLPPRKEQEIKESPYSPGYNQSFTTAST QTPPQCQLPSIHVEQTVHSQETANYHPDGTIQV SNGSLAFYPAQTNVFPRPTQPFVNSRGSVRGCT RGGRLITNSYRSPGGYKGFDTYRGLPSISNGNYS QLQFQAREYSGAPYSQRDNFQQCYKRGGTSGGP RANSRAGWSDSSQVSSPERDNETFNSGDSGQGD SRSMTPVDVPVTNPAATILPVHVYPLPQQMRVAF SAARTSNLAPGTLDQPIVFDLLLNNLGETFDLQ LGRFNCPVNGTYVFIFHMLKLAVNVPLYVNLMK NEEVLVSAYANDGAPDHETASNHAILQLFQGDQI WLRLHRGAIYGSSWKYSTFSGYLLYQD*KSVQY *Q*KDGVLISGIEGKVVFALMTDWFRKMFLFLE GGGPYFFVFLPEVKNQAE*QLALIWHFINCDVAS LVKL*MYIVCT*SLTVLTFSLLN*LPQVQASYN ALLCLNKKVTC

Frame 2

RCLQGSPWPLGRGALRSGSPGDLRGCALACMGP VLSLVWGCS*GGRKGYLGCLEVERRIRKCARAT D*GTGRAR*NELLNWLGVSGFGLV*TKQLRINA GFLQVERVPVCKCPVVMDCLVGPRAIGEVSILVQ EAAGSLRAIKECCEFGFSSKRSGLRLGLVVRDH VKRFEWLSLRSRCGKLILLVSSRGRGNYLECDL PS*EERSSEAVAVLPPYVENRISGNILRIGRFCL CKGYPYWLAALITLKVGWKYKYLKHHWVSSSLL WKRV*GSGLDFPGKLLPGCVPLVLILYLTFPHL LQPHLFQWCNSFHPLLVTSHLQAIQRRKERGI*S QPSPK*TTVSMGKASGP*APCSLL*VLLHLLPK RMRPILKMDSYALNTKLETSRKRSSNWRIIRIA *KVESILIQTSWKL*RNMKKCYIIWNLPRSFKKP FLG*A*IY*KRKRRPREGSTC*NLRLRRKSFEL YFKFSMYCRT*HRSTYKKTSKGV*MVQCICLQK NLTTSLSFQN*PALKEMKV*VLKTRWSSHPCTFG TFWKVVRKQW*ERHTNT*RIYCLNC*TQAILKV SQFPKMPRKRKYHWRKKC*YNQRKKHNYRRLNL SKSQSL*WNLPSQRYNHKSFLTDAI*QK*IIQTN KAKSNLGKQIMLENQISQNVGICLLNQMVKRRN RSPLSPGRLLVSTRRYPSLQFP*NRGNKTPQNS GLLCRKSRRSRRSPNPSHLLASGSKIHLNPKQGM FKRNKRNRRHQSCGQFSCRKNKIQRSKLQSLGH LPCRANRTPPSHGPLPCVKNRIQNSQRLQNPGK TMLRVKNTL*HHSHRFLQSPGE*LQQASYQMTSC CPGS*TQNPKMCLSLCISL*VLPLPFRRIQY*G KKNCRI**LRFKELVTLCKSLFLTLTNLQVQFQ RHNRLQLLQVAP*HLKNKICPVKVIFFKSRYRLL LLQLLVAQMLAWLLPIRLLLDLKQSL*PQRLLR YLTLMHLCLHEKNKK*KNPLIHLATIKVLPQQV HKHHPSANCHLYM*NKLSILKRLQIIILMELFK* AMVALPFTQHRRMCFPDLLSHLSIAGDLLEDVL VVGD**PIPIGPLVVIKVLILIEDSLQFPMEII ASCSSKLESILEHLIPKGIISSSVISEEGHLVVH EQIREQGGVILLR*AAQKETTKPLTVVTLDKET PVA*PLWMCQ*QIQQPPYCQYTSTLCLSRCELP SQQPEPLIWPLEL*TNLLCLIFF*TT*EKLLIFS LVDLIAQ*MALTFSFFTC*SWQ*MCHCMSTS*R MKRSWYQPMPMMVLQTMKLLAIMQFFSSSRETR YGYVCTGEQFMEVAGNILRFQAIFFIKIESQYSI DNKRMVF*LVGLKEK*SLPS*LIGLGKCFCS*R EEVLTFLFSFLR*KIKLNDN*H*SGTL*IVM*P R*SSCECILFALNP*LY*RSAY*TDCLKSRQVTM PCCASIKKLHA

Sequence NM_032156

GTCGGTGCCTGCAGGGCTCTCCGTGGCCGCTCGGGAGAGGTGCTCTTCGCTCAGGCTCCCCCGGAGACTTGAGGGGGTGCGCGCTGGCGTGCATGGGGCC TGTTCTGTCCTTGGTTTGGGGATGCTCCTAAGGGGGGAGAAAGGGATACCTCGGGTGCTTGGAGGTCGAGAGACGGATACGTAAGTGCGCAAGGGCCACT GATTAGGGCACGGGAAGGGCTCGCTAGAATGAGCTCTTAAACTGGTTGGGTGTAAGCGGTTTTGGGCTAGTCTAAACCAAACAACTGAGAATAAACGCGG GGTTCCTGCAGGTTGAGAGAGTACCTGTCTGCAAATGTCCAGTAGTGATGGATTGCCTTGTAGGCCCCAGAGCAATCGGGGAAGTTAGCATTCTTGTTCA AGAAGCTGCTGGTTCACTTAGAGCTATAAAAGAATGTTGTGAGTTTGGATTTTCTTCCAAACGTTCAGGATTGAGGTTAGGGCTGGTGGTGAGGGATCAT GTAAAGAGGTTTGAGTGGCTCAGCCTTAGGTCCCGGTGTGGAAAGCTTATTCTTTTGGTGTCATCACGTGGCCGTGGGAATTATTTAGAATGTGATCTGC CCTCATGAGAAGAAAGGAGCTCTGAAGCCGTTGCAGTTCTTCCTCCCTATGTGGAAAATCGAATTTCTGGAAACATCCTCCGTATTGGGAGATTTTGCCT ATGTAAAGGCTATCCTTATTGGCTAGCGGCACTAATTACTTTAAAAGTAGGATGGAAGTACAAGTATCTCAAGCATCATTGGGTTTCGAGCTCACTTCTG TGGAAAAGAGTTTAAGGGAGTGGTCTAGACTTTCCAGGGAAGTTATTGCCTGGCTGTGTCCCTCTAGTCCTAATTTTATACTTAACTTTCCCCCACCTCC TTCAGCCTCATCTGTTTCAATGGTGCAACTCTTTTCATCCCCTTTTGGTTACCAGTCACCTTCAGGCCATTCAGAGGAGGAAAGAGAGGGGAATATGAAG TCAGCCAAGCCCCAAGTGAACCACAGTCAGCATGGGGAAAGCCAGCGGGCCTTGAGCCCCCTGCAGTCTACTCTGAGTTCTGCTGCATCTCCTTCCCAAG CGTATGAGACCTATATTGAAAATGGACTCATATGCCTTAAACACAAAATTAGAAACATCGAGAAAAAGAAGCTCAAACTGGAGGATTATAAGGATCGCCT GAAAAGTGGAGAGCATCTTAATCCAGACCAGTTGGAAGCTGTAGAGAAATATGAAGAAGTGCTACATAATTTGGAATTTGCCAAGGAGCTTCAAAAAACC TTTTCTGGGTTGAGCCTAGATCTACTAAAAGCGCAAAAGAAGGCCCAGAGAAGGGAGCACATGCTAAAACTTGAGGCTGAGAAGAAAAAGCTTCGAACTA TACTTCAAGTTCAGTATGTATTGCAGAACTTGACACAGGAGCACGTACAAAAAGACTTCAAAGGGGGTTTGAATGGTGCAGTGTATTTGCCTTCAAAAGA ACTTGACTACCTCATTAAGTTTTCAAAACTGACCTGCCCTGAAAGAAATGAAAGTCTGAGACAAACACTTGAAGGATCTACTGTCTAAATTGCTGAACTC AGGCTATTTTGAAAGTATCCCAGTTCCCAAAAATGCCAAGGAAAAGGAAGTACCACTGGAGGAAGAAATGCTAATACAATCAGAGAAAAAAACACAATTA TCGAAGACTGAATCTGTCAAAGAGTCAGAGTCTCTAATGGAATTTGCCCAGCCAGAGATACAACCACAAGAGTTTCTTAACAGACGCTATATGACAGAAG TAGATTATTCAAACAAACAAGGCGAAGAGCAACCTTGGGAAGCAGATTATGCTAGAAAACCAAATCTCCCAAAACGTTGGGATATGCTTACTGAACCAGA TGGTCAAGAGAAGAAACAGGAGTCCTTTAAGTCCTGGGAGGCTTCTGGTAAGCACCAGGAGGTATCCAAGCCTGCAGTTTCCTTAGAACAGAGGAAACAA GACACCTCAAAACTCAGGTCTACTCTGCCGGAAGAGCAGAAGAAGCAGGAGATCTCCAAATCCAAGCCATCTCCTAGCCAGTGGAAGCAAGATACACCTA AATCCAAAGCAGGGTATGTTCAAGAGGAACAAAAGAAACAGGAGACACCAAAGCTGTGGCCAGTTCAGCTGCAGAAAGAACAAGATCCAAAGAAGCAAAC TCCAAAGTCTTGGACACCTTCCATGCAGAGCGAACAGAACACCACCAAGTCATGGACCACTCCCATGTGTGAAGAACAGGATTCAAAACAGCCAGAGACT CCAAAATCCTGGGAAAACAATGTTGAGAGTCAAAAACACTCTTTAACATCACAGTCACAGATTTCTCCAAAGTCCTGGGGAGTAGCTACAGCAAGCCTCA TACCAAATGACCAGCTGCTGCCCAGGAAGTTGAACACAGAACCCAAAGATGTGCCTAAGCCTGTGCATCAGCCTGTAGGTTCTTCCTCTACCCTTCCGAA GGATCCAGTATTGAGGAAAGAAAAACTGCAGGATCTGATGACTCAGATTCAAGGAACTTGTAACTTTATGCAAGAGTCTGTTCTTGACTTTGACAAACCT TCAAGTGCAATTCCAACGTCACAACCGCCTTCAGCTACTCCAGGTAGCCCCGTAGCATCTAAAGAACAAAATCTGTCCAGTCAAAGTGATTTTCTTCAAG AGCCGTTACAGGCTACTTCTTCTCCAGTTACTTGTAGCTCAAATGCTTGCTTGGTTACTACCGATCAGGCTTCTTCTGGATCTGAAACAGAGTTTATGAC CTCAGAGACTCCTGAGGCAGCAATTCCCCCAGGCAAGCAACCGTCTTCACTAGCTTCTCCAAATCCTCCCATGGCAAAGGGCTCTGAACAGGGCTTCCAG TCACCTCCAGCAAGTAGTAGTTCAGTAACCATTAACACAGCACCCTTTCAAGCCATGCAGACAGTATTTAACGTTAATGCACCTCTGCCTCCACGAAAAG AACAAGAAATAAAAGAATCCCCTTATTCACCTGGCTACAATCAAAGTTTTACCACAGCAAGTACACAAACACCACCCCAGTGCCAACTGCCATCTATACA TGTAGAACAAACTGTCCATTCTCAAGAGACTGCAAATTATCATCCTGATGGAACTATTCAAGTAAGCAATGGTAGCCTTGCCTTTTACCCAGCACAGACG AATGTGTTTCCCAGACCTACTCAGCCATTTGTCAATAGCCGGGGATCTGTTAGAGGATGTACTCGTGGTGGGAGATTAATAACCAATTCCTATCGGTCCC CTGGTGGTTATAAAGGTTTTGATACTTATAGAGGACTCCCTTCAATTTCCAATGGAAATTATAGCCAGCTGCAGTTCCAAGCTAGAGAGTATTCTGGAGC ACCTTATTCCCAAAGGGATAATTTCCAGCAGTGTTATAAGCGAGGAGGGACATCTGGTGGTCCACGAGCAAATTCGAGAGCAGGGTGGAGTGATTCTTCT CAGGTGAGCAGCCCAGAAAGAGACAACGAAACCTTTAACAGTGGTGACTCTGGACAAGGAGACTCCCGTAGCATGACCCCTGTGGATGTGCCAGTGACAA ATCCAGCAGCCACCATACTGCCAGTACACGTCTACCCTCTGCCTCAGCAGATGCGAGTTGCCTTCTCAGCAGCCAGAACCTCTAATCTGGCCCCTGGAAC TTTAGACCAACCTATTGTGTTTGATCTTCTTCTGAACAACTTAGGAGAAACTTTTGATCTTCAGCTTGGTAGATTTAATTGCCCAGTGAATGGCACTTAC GTTTTCATTTTTCACATGCTAAAGCTGGCAGTGAATGTGCCACTGTATGTCAACCTCATGAAGAATGAAGAGGTCTTGGTATCAGCCTATGCCAATGATG GTGCTCCAGACCATGAAACTGCTAGCAATCATGCAATTCTTCAGCTCTTCCAGGGAGACCAGATATGGTTACGTCTGCACAGGGGAGCAATTTATGGAAG TAGCTGGAAATATTCTACGTTTTCAGGCTATCTTCTTTATCAAGATTGAAAGTCAGTACAGTATTGACAATAAAAGGATGGTGTTCTAATTAGTGGGATT GAAGGAAAAGTAGTCTTTGCCCTCATGACTGATTGGTTTAGGAAAATGTTTTTGTTCCTAGAGGGAGGAGGTCCTTACTTTTTTGTTTTCCTTCCTGAGG TGAAAAATCAAGCTGAATGACAATTAGCACTAATCTGGCACTTTATAAATTGTGATGTAGCCTCGCTAGTCAAGCTGTGAATGTATATTGTTTGCACTTA ATCCTTAACTGTATTAACGTTCAGCTTACTAAACTGACTGCCTCAAGTCCAGGCAAGTTACAATGCCTTGTTGTGCCTCAATAAAAAAGTTACATGCAC

refseq_C1QDC1.F3 (forward primer)
refseq_C1QDC1.R3 (reverse primer)
Single exon skipping

Frame 0

VGACRALRGRSGEVLFAQAPPET*GGARWRAWG LFCPWFGDAPKGGERDTSGAWRSRDGYVSAQGPL IRAREGLARMSS*TGWV*AVLG*SKPNN*E*TR GSCRLREYLSANVQ**WIAL*APEQSGKLAFLF KKLLVHLEL*KNVVSLDFLPNVQD*G*GWW*GIM *RGLSGSALGPGVESLFFWCHHVAVGII*NVIC PHEKKGALKPLQFFLPMWKIEFLETSSVLGDFA YVKAILIG*RH*LL*K*DGSTSISSIIGFRAHFC GKEFKGVV*TFQGSYCLAVSL*S*FYT*LSPTS FSLICFNGATLFIPFWLPVTFRPFRGGKRGEYE VSQAPSEPQSAWGKPAGLEPPAVYSEFCCISFPS V*DLY*KWTHMP*TQN*KHREKEAQTGGL*GSP EKWRAS*SRPVGSCREI*RSAT*FGICQGASKN LFWVEPRSTKSAKEGPEKGAHAKT*G*EEKASNY TSSSVCIAELDTGARTKRLQRGFEWCSVFAFKR T*LPH*VFKTDLP*KK*KSETNT*RIYCLNC*T QAILKVSQFPKMPRKRKYHWRKKC*YNQRKKHNY RRLNLSKSQSL*WNLPSQRYNHKSFLTDAI*QK *IIQTNKAKSNLGKQIMLENQISQNVGICLLNQ MVKRRNRSPLSPGRLLVSTRRYPSLQFP*NRGNK TPQNSGLLCRKSRRSRRSPNPSHLLASGSKIHL NPKQGMFKRNKRNRRHQSCGQFSCRKNKIQRSK LQSLGHLPCRANRTPPSHGPLPCVKNRIQNSQRL QNPGKTMLRVKNTL*HHSHRFLQSPGE*LQQAS YQMTSCCPGS*TQNPKMCLSLCISL*VLPLPFR RIQY*GKKNCRI**LRFKELVTLCKSLFLTLTNL QVQFQRHNRLQLLQVAP*HLKNKICPVKVIFFK SRYRLLLLQLLVAQMLAWLLPIRLLLDLKQSL* PQRLLRQQFPQASNRLH*LLQILPWQRALNRASS HLQQVVVQ*PLTQHPFKPCRQYLTLMHLCLHEK NKK*KNPLIHLATIKVLPQQVHKHHPSANCHLY M*NKLSILKRLQIIILMELFK*AMVALPFTQHRR MCFPDLLSHLSIAGDLLEDVLVVGD**PIPIGP LVVIKVLILIEDSLQFPMEIIASCSSKLESILE HLIPKGIISSSVISEEGHLVVHEQIREQGGVILL R*AAQKETTKPLTVVTLDKETPVA*PLWMCQ*Q IQQPPYCQYTSTLCLSRCELPSQQPEPLIWPLE L*TNLLCLIFF*TT*EKLLIFSLVDLIAQ*MALT FSFFTC*SWQ*MCHCMSTS*RMKRSWYQPMPMM VLQTMKLLAIMQFFSSSRETRYGYVCTGEQFME VAGNILRFQAIFFIKIESQYSIDNKRMVF*LVGL KEK*SLPS*LIGLGKCFCS*REEVLTFLFSFLR *KIKLNDN*H*SGTL*IVM*PR*SSCECILFAL NP*LY*RSAY*TDCLKSRQVTMPCCASIKKLHA

Frame 1

SVPAGLSVAARERCSSLRLPRRLEGVRAGVHGA CSVLGLGMLLRGEKGIPRVLGGRETDT*VRKGH *LGHGKGSLE*ALKLVGCKRFWASLNQTTENKRG VPAG*ESTCLQMSSSDGLPCRPQSNRGS*HSCS RSCWFT*SYKRML*VWIFFQTFRIEVRAGGEGS CKEV*VAQP*VPVWKAYSFGVITWPWELFRM*SA LMRRKEL*SRCSSSSLCGKSNFWKHPPYWEILP M*RLSLLASGTNYFKSRMEVQVSQASLGFELTS VEKSLREWSRLSREVIAWLCPSSPNFILNFPPPP SASSVSMVQLFSSPFGYQSPSGHSEEEREGNMK SAKPQVNHSQHGESQRALSPLQSTLSSAASPSQ AYETYIENGLICLKHKIRNIEKKKLKLEDYKDRL KSGEHLNPDQLEAVEKYEEVLHNLEFAKELQKT FSGLSLDLLKAQKKAQRREHMLKLEAEKKKLRT ILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKE LDYLIKFSKLTCPERNESLRQTLEGSTV*IAEL RLF*KYPSSQKCQGKGSTTGGRNANTIREKNTI IED*ICQRVRVSNGICPARDTTTRVS*QTLYDRS RLFKQTRRRATLGSRLC*KTKSPKTLGYAY*TR WSREETGVL*VLGGFW*APGGIQACSFLRTEET RHLKTQVYSAGRAEEAGDLQIQAIS*PVEARYT* IQSRVCSRGTKETGDTKAVASSAAERTRSKEAN SKVLDTFHAERTEHHQVMDHSHV*RTGFKTARD SKILGKQC*ESKTLFNITVTDFSKVLGSSYSKPH TK*PAAAQEVEHRTQRCA*ACASACRFFLYPSE GSSIEERKTAGSDDSDSRNL*LYARVCS*L*QT FKCNSNVTTAFSYSR*PRSI*RTKSVQSK*FSSR AVTGYFFSSYL*LKCLLGYYRSGFFWI*NRVYD LRDS*GSNSPRQATVFTSFSKSSHGKGL*TGLP VTSSK**FSNH*HSTLSSHADSI*R*CTSASTKR TRNKRIPLFTWLQSKFYHSKYTNTTPVPTAIYT CRTNCPFSRDCKLSS*WNYSSKQW*PCLLPSTD ECVSQTYSAICQ*PGIC*RMYSWWEINNQFLSVP WWL*RF*YL*RTPFNFQWKL*PAAVPS*RVFWS TLFPKG*FPAVL*ARRDIWWSTSKFESRVE*FF SGEQPRKRQRNL*QW*LWTRRLP*HDPCGCASDK SSSHHTASTRLPSASADASCLLSSQNL*SGPWN FRPTYCV*SSSEQLRRNF*SSAW*I*LPSEWHL RFHFSHAKAGSECATVCQPHEE*RGLGISLCQ*W CSRP*NC*QSCNSSALPGRPDMVTSAQGSNLWK *LEIFYVFRLSSLSRLKVSTVLTIKGWCSN*WD *RKSSLCPHD*LV*ENVFVPRGRRSLLFCFPS*G EKSS*MTISTNLALYKL*CSLASQAVNVYCLHL ILNCINVQLTKLTASSPGKLQCLVVPQ*KSYMH

Frame 2

RCLQGSPWPLGRGALRSGSPGDLRGCALACMGP VLSLVWGCS*GGRKGYLGCLEVERRIRKCARAT D*GTGRAR*NELLNWLGVSGFGLV*TKQLRINA GFLQVERVPVCKCPVVMDCLVGPRAIGEVSILVQ EAAGSLRAIKECCEFGFSSKRSGLRLGLVVRDH VKRFEWLSLRSRCGKLILLVSSRGRGNYLECDL PS*EERSSEAVAVLPPYVENRISGNILRIGRFCL CKGYPYWLAALITLKVGWKYKYLKHHWVSSSLL WKRV*GSGLDFPGKLLPGCVPLVLILYLTFPHL LQPHLFQWCNSFHPLLVTSHLQAIQRRKERGI*S QPSPK*TTVSMGKASGP*APCSLL*VLLHLLPK RMRPILKMDSYALNTKLETSRKRSSNWRIIRIA *KVESILIQTSWKL*RNMKKCYIIWNLPRSFKKP FLG*A*IY*KRKRRPREGSTC*NLRLRRKSFEL YFKFSMYCRT*HRSTYKKTSKGV*MVQCICLQK NLTTSLSFQN*PALKEMKV*DKHLKDLLSKLLNS GYFESIPVPKNAKEKEVPLEEEMLIQSEKKTQL SKTESVKESESLMEFAQPEIQPQEFLNRRYMTE VDYSNKQGEEQPWEADYARKPNLPKRWDMLTEPD GQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQ DTSKLRSTLPEEQKKQEISKSKPSPSQWKQDTP KSKAGYVQEEQKKQETPKLWPVQLQKEQDPKKQT PKSWTPSMQSEQNTTKSWTTPMCEEQDSKQPET PKSWENNVESQKHSLTSQSQISPKSWGVATASL IPNDQLLPRKLNTEPKDVPKPVHQPVGSSSTLPK DPVLRKEKLQDLMTQIQGTCNFMQESVLDFDKP SSAIPTSQPPSATPGSPVASKEQNLSSQSDFLQ EPLQATSSPVTCSSNACLVTTDQASSGSETEFMT SETPEAAIPPGKQPSSLASPNPPMAKGSEQGFQ SPPASSSSVTINTAPFQAMQTVFNVNAPLPPRK EQEIKESPYSPGYNQSFTTASTQTPPQCQLPSIH VEQTVHSQETANYHPDGTIQVSNGSLAFYPAQT NVFPRPTQPFVNSRGSVRGCTRGGRLITNSYRS PGGYKGFDTYRGLPSISNGNYSQLQFQAREYSGA PYSQRDNFQQCYKRGGTSGGPRANSRAGWSDSS QVSSPERDNETFNSGDSGQGDSRSMTPVDVPVT NPAATILPVHVYPLPQQMRVAFSAARTSNLAPGT LDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTY VFIFHMLKLAVNVPLYVNLMKNEEVLVSAYAND GAPDHETASNHAILQLFQGDQIWLRLHRGAIYGS SWKYSTFSGYLLYQD*KSVQY*Q*KDGVLISGI EGKVVFALMTDWFRKMFLFLEGGGPYFFVFLPE VKNQAE*QLALIWHFINCDVASLVKL*MYIVCT* SLTVLTFSLLN*LPQVQASYNALLCLNKKVTC

Sequence NM_001002259

GTCGGTGCCTGCAGGGCTCTCCGTGGCCGCTCGGGAGAGGTGCTCTTCGCTCAGGCTCCCCCGGAGACTTGAGGGGGTGCGCGCTGGCGTGCATGGGGCC TGTTCTGTCCTTGGTTTGGGGATGCTCCTAAGGGGGGAGAAAGGGATACCTCGGGTGCTTGGAGGTCGAGAGACGGATACGTAAGTGCGCAAGGGCCACT GATTAGGGCACGGGAAGGGCTCGCTAGAATGAGCTCTTAAACTGGTTGGGTGTAAGCGGTTTTGGGCTAGTCTAAACCAAACAACTGAGAATAAACGCGG GGTTCCTGCAGGTTGAGAGAGTACCTGTCTGCAAATGTCCAGTAGTGATGGATTGCCTTGTAGGCCCCAGAGCAATCGGGGAAGTTAGCATTCTTGTTCA AGAAGCTGCTGGTTCACTTAGAGCTATAAAAGAATGTTGTGAGTTTGGATTTTCTTCCAAACGTTCAGGATTGAGGTTAGGGCTGGTGGTGAGGGATCAT GTAAAGAGGTTTGAGTGGCTCAGCCTTAGGTCCCGGTGTGGAAAGCTTATTCTTTTGGTGTCATCACGTGGCCGTGGGAATTATTTAGAATGTGATCTGC CCTCATGAGAAGAAAGGAGCTCTGAAGCCGTTGCAGTTCTTCCTCCCTATGTGGAAAATCGAATTTCTGGAAACATCCTCCGTATTGGGAGATTTTGCCT ATGTAAAGGCTATCCTTATTGGCTAGCGGCACTAATTACTTTAAAAGTAGGATGGAAGTACAAGTATCTCAAGCATCATTGGGTTTCGAGCTCACTTCTG TGGAAAAGAGTTTAAGGGAGTGGTCTAGACTTTCCAGGGAAGTTATTGCCTGGCTGTGTCCCTCTAGTCCTAATTTTATACTTAACTTTCCCCCACCTCC TTCAGCCTCATCTGTTTCAATGGTGCAACTCTTTTCATCCCCTTTTGGTTACCAGTCACCTTCAGGCCATTCAGAGGAGGAAAGAGAGGGGAATATGAAG TCAGCCAAGCCCCAAGTGAACCACAGTCAGCATGGGGAAAGCCAGCGGGCCTTGAGCCCCCTGCAGTCTACTCTGAGTTCTGCTGCATCTCCTTCCCAAG CGTATGAGACCTATATTGAAAATGGACTCATATGCCTTAAACACAAAATTAGAAACATCGAGAAAAAGAAGCTCAAACTGGAGGATTATAAGGATCGCCT GAAAAGTGGAGAGCATCTTAATCCAGACCAGTTGGAAGCTGTAGAGAAATATGAAGAAGTGCTACATAATTTGGAATTTGCCAAGGAGCTTCAAAAAACC TTTTCTGGGTTGAGCCTAGATCTACTAAAAGCGCAAAAGAAGGCCCAGAGAAGGGAGCACATGCTAAAACTTGAGGCTGAGAAGAAAAAGCTTCGAACTA TACTTCAAGTTCAGTATGTATTGCAGAACTTGACACAGGAGCACGTACAAAAAGACTTCAAAGGGGGTTTGAATGGTGCAGTGTATTTGCCTTCAAAAGA ACTTGACTACCTCATTAAGTTTTCAAAACTGACCTGCCCTGAAAGAAATGAAAGTCTGAGTGTTGAAGACCAGATGGAGCAGTCATCCTTGTACTTTTGG GACCTTTTGGAAGGTAGTGAGAAAGCAGTGGTAGGAACGACATACAAACACTTGAAGGATCTACTGTCTAAATTGCTGAACTCAGGCTATTTTGAAAGTA TCCCAGTTCCCAAAAATGCCAAGGAAAAGGAAGTACCACTGGAGGAAGAAATGCTAATACAATCAGAGAAAAAAACACAATTATCGAAGACTGAATCTGT CAAAGAGTCAGAGTCTCTAATGGAATTTGCCCAGCCAGAGATACAACCACAAGAGTTTCTTAACAGACGCTATATGACAGAAGTAGATTATTCAAACAAA CAAGGCGAAGAGCAACCTTGGGAAGCAGATTATGCTAGAAAACCAAATCTCCCAAAACGTTGGGATATGCTTACTGAACCAGATGGTCAAGAGAAGAAAC AGGAGTCCTTTAAGTCCTGGGAGGCTTCTGGTAAGCACCAGGAGGTATCCAAGCCTGCAGTTTCCTTAGAACAGAGGAAACAAGACACCTCAAAACTCAG GTCTACTCTGCCGGAAGAGCAGAAGAAGCAGGAGATCTCCAAATCCAAGCCATCTCCTAGCCAGTGGAAGCAAGATACACCTAAATCCAAAGCAGGGTAT GTTCAAGAGGAACAAAAGAAACAGGAGACACCAAAGCTGTGGCCAGTTCAGCTGCAGAAAGAACAAGATCCAAAGAAGCAAACTCCAAAGTCTTGGACAC CTTCCATGCAGAGCGAACAGAACACCACCAAGTCATGGACCACTCCCATGTGTGAAGAACAGGATTCAAAACAGCCAGAGACTCCAAAATCCTGGGAAAA CAATGTTGAGAGTCAAAAACACTCTTTAACATCACAGTCACAGATTTCTCCAAAGTCCTGGGGAGTAGCTACAGCAAGCCTCATACCAAATGACCAGCTG CTGCCCAGGAAGTTGAACACAGAACCCAAAGATGTGCCTAAGCCTGTGCATCAGCCTGTAGGTTCTTCCTCTACCCTTCCGAAGGATCCAGTATTGAGGA AAGAAAAACTGCAGGATCTGATGACTCAGATTCAAGGAACTTGTAACTTTATGCAAGAGTCTGTTCTTGACTTTGACAAACCTTCAAGTGCAATTCCAAC GTCACAACCGCCTTCAGCTACTCCAGGTAGCCCCGTAGCATCTAAAGAACAAAATCTGTCCAGTCAAAGTGATTTTCTTCAAGAGCCGTTACAGGCTACT TCTTCTCCAGTTACTTGTAGCTCAAATGCTTGCTTGGTTACTACCGATCAGGCTTCTTCTGGATCTGAAACAGAGTTTATGACCTCAGAGACTCCTGAGG CAGCAATTCCCCCAGGCAAGCAACCGTCTTCACTAGCTTCTCCAAATCCTCCCATGGCAAAGGGCTCTGAACAGGGCTTCCAGTCACCTCCAGCAAGTAG TAGTTCAGTAACCATTAACACAGCACCCTTTCAAGCCATGCAGACAGTATTTAACGTTAATGCACCTCTGCCTCCACGAAAAGAACAAGAAATAAAAGAA TCCCCTTATTCACCTGGCTACAATCAAAGTTTTACCACAGCAAGTACACAAACACCACCCCAGTGCCAACTGCCATCTATACATGTAGAACAAACTGTCC ATTCTCAAGAGACTGCAGCAAATTATCATCCTGATGGAACTATTCAAGTAAGCAATGGTAGCCTTGCCTTTTACCCAGCACAGACGAATGTGTTTCCCAG ACCTACTCAGCCATTTGTCAATAGCCGGGGATCTGTTAGAGGATGTACTCGTGGTGGGAGATTAATAACCAATTCCTATCGGTCCCCTGGTGGTTATAAA GGTTTTGATACTTATAGAGGACTCCCTTCAATTTCCAATGGAAATTATAGCCAGCTGCAGTTCCAAGCTAGAGAGTATTCTGGAGCACCTTATTCCCAAA GGGATAATTTCCAGCAGTGTTATAAGCGAGGAGGGACATCTGGTGGTCCACGAGCAAATTCGAGAGCAGGGTGGAGTGATTCTTCTCAGGTGAGCAGCCC AGAAAGAGACAACGAAACCTTTAACAGTGGTGACTCTGGACAAGGAGACTCCCGTAGCATGACCCCTGTGGATGTGCCAGTGACAAATCCAGCAGCCACC ATACTGCCAGTACACGTCTACCCTCTGCCTCAGCAGATGCGAGTTGCCTTCTCAGCAGCCAGAACCTCTAATCTGGCCCCTGGAACTTTAGACCAACCTA TTGTGTTTGATCTTCTTCTGAACAACTTAGGAGAAACTTTTGATCTTCAGCTTGGTAGATTTAATTGCCCAGTGAATGGCACTTACGTTTTCATTTTTCA CATGCTAAAGCTGGCAGTGAATGTGCCACTGTATGTCAACCTCATGAAGAATGAAGAGGTCTTGGTATCAGCCTATGCCAATGATGGTGCTCCAGACCAT GAAACTGCTAGCAATCATGCAATTCTTCAGCTCTTCCAGGGAGACCAGATATGGTTACGTCTGCACAGGGGAGCAATTTATGGAAGTAGCTGGAAATATT CTACGTTTTCAGGCTATCTTCTTTATCAAGATTGAAAGTCAGTACAGTATTGACAATAAAAGGATGGTGTTCTAATTAGTGGGATTGAAGGAAAAGTAGT CTTTGCCCTCATGACTGATTGGTTTAGGAAAATGTTTTTGTTCCTAGAGGGAGGAGGTCCTTACTTTTTTGTTTTCCTTCCTGAGGTGAAAAATCAAGCT GAATGACAATTAGCACTAATCTGGCACTTTATAAATTGTGATGTAGCCTCGCTAGTCAAGCTGTGAATGTATATTGTTTGCACTTAATCCTTAACTGTAT TAACGTTCAGCTTACTAAACTGACTGCCTCAAGTCCAGGCAAGTTACAATGCCTTGTTGTGCCTCAATAAAAAAGTTACATGCAC

refseq_C1QDC1.F3 (forward primer)
refseq_C1QDC1.R3 (reverse primer)
Single exon skipping

Frame 0

VGACRALRGRSGEVLFAQAPPET*GGARWRAWG LFCPWFGDAPKGGERDTSGAWRSRDGYVSAQGPL IRAREGLARMSS*TGWV*AVLG*SKPNN*E*TR GSCRLREYLSANVQ**WIAL*APEQSGKLAFLF KKLLVHLEL*KNVVSLDFLPNVQD*G*GWW*GIM *RGLSGSALGPGVESLFFWCHHVAVGII*NVIC PHEKKGALKPLQFFLPMWKIEFLETSSVLGDFA YVKAILIG*RH*LL*K*DGSTSISSIIGFRAHFC GKEFKGVV*TFQGSYCLAVSL*S*FYT*LSPTS FSLICFNGATLFIPFWLPVTFRPFRGGKRGEYE VSQAPSEPQSAWGKPAGLEPPAVYSEFCCISFPS V*DLY*KWTHMP*TQN*KHREKEAQTGGL*GSP EKWRAS*SRPVGSCREI*RSAT*FGICQGASKN LFWVEPRSTKSAKEGPEKGAHAKT*G*EEKASNY TSSSVCIAELDTGARTKRLQRGFEWCSVFAFKR T*LPH*VFKTDLP*KK*KSEC*RPDGAVILVLL GPFGR**ESSGRNDIQTLEGSTV*IAELRLF*KY PSSQKCQGKGSTTGGRNANTIREKNTIIED*IC QRVRVSNGICPARDTTTRVS*QTLYDRSRLFKQ TRRRATLGSRLC*KTKSPKTLGYAY*TRWSREET GVL*VLGGFW*APGGIQACSFLRTEETRHLKTQ VYSAGRAEEAGDLQIQAIS*PVEARYT*IQSRV CSRGTKETGDTKAVASSAAERTRSKEANSKVLDT FHAERTEHHQVMDHSHV*RTGFKTARDSKILGK QC*ESKTLFNITVTDFSKVLGSSYSKPHTK*PA AAQEVEHRTQRCA*ACASACRFFLYPSEGSSIEE RKTAGSDDSDSRNL*LYARVCS*L*QTFKCNSN VTTAFSYSR*PRSI*RTKSVQSK*FSSRAVTGY FFSSYL*LKCLLGYYRSGFFWI*NRVYDLRDS*G SNSPRQATVFTSFSKSSHGKGL*TGLPVTSSK* *FSNH*HSTLSSHADSI*R*CTSASTKRTRNKR IPLFTWLQSKFYHSKYTNTTPVPTAIYTCRTNCP FSRDCSKLSS*WNYSSKQW*PCLLPSTDECVSQ TYSAICQ*PGIC*RMYSWWEINNQFLSVPWWL* RF*YL*RTPFNFQWKL*PAAVPS*RVFWSTLFPK G*FPAVL*ARRDIWWSTSKFESRVE*FFSGEQP RKRQRNL*QW*LWTRRLP*HDPCGCASDKSSSH HTASTRLPSASADASCLLSSQNL*SGPWNFRPTY CV*SSSEQLRRNF*SSAW*I*LPSEWHLRFHFS HAKAGSECATVCQPHEE*RGLGISLCQ*WCSRP *NC*QSCNSSALPGRPDMVTSAQGSNLWK*LEIF YVFRLSSLSRLKVSTVLTIKGWCSN*WD*RKSS LCPHD*LV*ENVFVPRGRRSLLFCFPS*GEKSS *MTISTNLALYKL*CSLASQAVNVYCLHLILNCI NVQLTKLTASSPGKLQCLVVPQ*KSYMH

Frame 1

SVPAGLSVAARERCSSLRLPRRLEGVRAGVHGA CSVLGLGMLLRGEKGIPRVLGGRETDT*VRKGH *LGHGKGSLE*ALKLVGCKRFWASLNQTTENKRG VPAG*ESTCLQMSSSDGLPCRPQSNRGS*HSCS RSCWFT*SYKRML*VWIFFQTFRIEVRAGGEGS CKEV*VAQP*VPVWKAYSFGVITWPWELFRM*SA LMRRKEL*SRCSSSSLCGKSNFWKHPPYWEILP M*RLSLLASGTNYFKSRMEVQVSQASLGFELTS VEKSLREWSRLSREVIAWLCPSSPNFILNFPPPP SASSVSMVQLFSSPFGYQSPSGHSEEEREGNMK SAKPQVNHSQHGESQRALSPLQSTLSSAASPSQ AYETYIENGLICLKHKIRNIEKKKLKLEDYKDRL KSGEHLNPDQLEAVEKYEEVLHNLEFAKELQKT FSGLSLDLLKAQKKAQRREHMLKLEAEKKKLRT ILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKE LDYLIKFSKLTCPERNESLSVEDQMEQSSLYFW DLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFES IPVPKNAKEKEVPLEEEMLIQSEKKTQLSKTESV KESESLMEFAQPEIQPQEFLNRRYMTEVDYSNK QGEEQPWEADYARKPNLPKRWDMLTEPDGQEKK QESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLR STLPEEQKKQEISKSKPSPSQWKQDTPKSKAGY VQEEQKKQETPKLWPVQLQKEQDPKKQTPKSWT PSMQSEQNTTKSWTTPMCEEQDSKQPETPKSWEN NVESQKHSLTSQSQISPKSWGVATASLIPNDQL LPRKLNTEPKDVPKPVHQPVGSSSTLPKDPVLR KEKLQDLMTQIQGTCNFMQESVLDFDKPSSAIPT SQPPSATPGSPVASKEQNLSSQSDFLQEPLQAT SSPVTCSSNACLVTTDQASSGSETEFMTSETPE AAIPPGKQPSSLASPNPPMAKGSEQGFQSPPASS SSVTINTAPFQAMQTVFNVNAPLPPRKEQEIKE SPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTV HSQETAANYHPDGTIQVSNGSLAFYPAQTNVFPR PTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYK GFDTYRGLPSISNGNYSQLQFQAREYSGAPYSQ RDNFQQCYKRGGTSGGPRANSRAGWSDSSQVSSP ERDNETFNSGDSGQGDSRSMTPVDVPVTNPAAT ILPVHVYPLPQQMRVAFSAARTSNLAPGTLDQP IVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFH MLKLAVNVPLYVNLMKNEEVLVSAYANDGAPDH ETASNHAILQLFQGDQIWLRLHRGAIYGSSWKY STFSGYLLYQD*KSVQY*Q*KDGVLISGIEGKVV FALMTDWFRKMFLFLEGGGPYFFVFLPEVKNQA E*QLALIWHFINCDVASLVKL*MYIVCT*SLTV LTFSLLN*LPQVQASYNALLCLNKKVTC

Frame 2

RCLQGSPWPLGRGALRSGSPGDLRGCALACMGP VLSLVWGCS*GGRKGYLGCLEVERRIRKCARAT D*GTGRAR*NELLNWLGVSGFGLV*TKQLRINA GFLQVERVPVCKCPVVMDCLVGPRAIGEVSILVQ EAAGSLRAIKECCEFGFSSKRSGLRLGLVVRDH VKRFEWLSLRSRCGKLILLVSSRGRGNYLECDL PS*EERSSEAVAVLPPYVENRISGNILRIGRFCL CKGYPYWLAALITLKVGWKYKYLKHHWVSSSLL WKRV*GSGLDFPGKLLPGCVPLVLILYLTFPHL LQPHLFQWCNSFHPLLVTSHLQAIQRRKERGI*S QPSPK*TTVSMGKASGP*APCSLL*VLLHLLPK RMRPILKMDSYALNTKLETSRKRSSNWRIIRIA *KVESILIQTSWKL*RNMKKCYIIWNLPRSFKKP FLG*A*IY*KRKRRPREGSTC*NLRLRRKSFEL YFKFSMYCRT*HRSTYKKTSKGV*MVQCICLQK NLTTSLSFQN*PALKEMKV*VLKTRWSSHPCTFG TFWKVVRKQW*ERHTNT*RIYCLNC*TQAILKV SQFPKMPRKRKYHWRKKC*YNQRKKHNYRRLNL SKSQSL*WNLPSQRYNHKSFLTDAI*QK*IIQTN KAKSNLGKQIMLENQISQNVGICLLNQMVKRRN RSPLSPGRLLVSTRRYPSLQFP*NRGNKTPQNS GLLCRKSRRSRRSPNPSHLLASGSKIHLNPKQGM FKRNKRNRRHQSCGQFSCRKNKIQRSKLQSLGH LPCRANRTPPSHGPLPCVKNRIQNSQRLQNPGK TMLRVKNTL*HHSHRFLQSPGE*LQQASYQMTSC CPGS*TQNPKMCLSLCISL*VLPLPFRRIQY*G KKNCRI**LRFKELVTLCKSLFLTLTNLQVQFQ RHNRLQLLQVAP*HLKNKICPVKVIFFKSRYRLL LLQLLVAQMLAWLLPIRLLLDLKQSL*PQRLLR QQFPQASNRLH*LLQILPWQRALNRASSHLQQV VVQ*PLTQHPFKPCRQYLTLMHLCLHEKNKK*KN PLIHLATIKVLPQQVHKHHPSANCHLYM*NKLS ILKRLQQIIILMELFK*AMVALPFTQHRRMCFP DLLSHLSIAGDLLEDVLVVGD**PIPIGPLVVIK VLILIEDSLQFPMEIIASCSSKLESILEHLIPK GIISSSVISEEGHLVVHEQIREQGGVILLR*AA QKETTKPLTVVTLDKETPVA*PLWMCQ*QIQQPP YCQYTSTLCLSRCELPSQQPEPLIWPLEL*TNL LCLIFF*TT*EKLLIFSLVDLIAQ*MALTFSFF TC*SWQ*MCHCMSTS*RMKRSWYQPMPMMVLQTM KLLAIMQFFSSSRETRYGYVCTGEQFMEVAGNI LRFQAIFFIKIESQYSIDNKRMVF*LVGLKEK* SLPS*LIGLGKCFCS*REEVLTFLFSFLR*KIKL NDN*H*SGTL*IVM*PR*SSCECILFALNP*LY *RSAY*TDCLKSRQVTMPCCASIKKLHA