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Sequences

Sequence NM_199348

AATAATGCACCTGACTTTACCAGGGGGGAACAACCAGCCGAGTAGAACAAGGAACAGATGTAAAGGGAATAAAAGGAGAGAGAAAAAGAGATGAGATTCG
TTTAAAGAAATCCAGGGGCAGAAGAGGTGGCTGCCGCGGCAGAGGCAGCTAGAGCTTACTTCCCTGTCTGCGTGAGCTGCAGGCAGAGGACGCTTTCACC
AGTTGCAGATGTAACCTCGGGAATTCCTGGGCCGTCGGTTTGTTTGCCAAACAAAGTCTTTTCTTCTCTGGCTCAGACACTGAAGAGGCTCCTGGATTTT
TCTGCGATCCTGCCACAAGCTGGCAGTTACCCGAGAGCCTTCCCAAGGAGCTGGAGGAGAAATGAGCCCTTGTGGGCGGAAGATGGGCGAAGGGCGTCAG
CAGCGGCGGGCTCCGGTCGGGAAGCTCCTTCTGCTCCCCGGGAGGAGAGATACACCCCATGGGCGGTCAGGCAGCAGCGGCGCCAGGACGCAGCGCTCCC
TGCTCTGGCTCTTGGTGCACGTGTGGCTGTGGGCGGCCTCGGGCTCCTCTGCCCAGTTGTTCAACCTCACCCTTTCCGTAGATGAGGGGCTTCCCCCGGA
CACGCTGGTAGGTGACATCCGCGCCGGGCTGCCGGCCGCGCAGCAGCAGGAGGGGAGCGGCTTCTTTCTGTCGGAGGACTCCGATGACTCCCCGCTGCTG
GACGACTTCCACGTGCACCCGGACACCGGCATCATCCGCACTGCGCGGCGCCTGGACCGCGAGCGGCGGGACCACTACAGCTTCGTCGCCGCCACGCTGC
TGGGCGCTGTGGTGCAGGTGGAGATTCGCGTCAACGACGTGAATGACCACTCGCCCCGCTTTCCCCTCGACTCCCTGCAACTCGACGTCTCCGAGCTCAG
CCCGCCAGGGACCGCCTTCCGCCTGCCAGTTGCCCACGATCCGGACGCCGGACTGTTCAGCACTCAGGGCTACACCCTGGTGCAACCGTCCGACCTGCCC
AAGGACCCCGCAGGCCCGTTCTTCCAGTTGCGCTACCGGACTCCGGGGCCACTACCGTCACCGCTTTTGCCAGGCTCCTCGTCACCCCTGGAGCCTCTAG
ATCTGGTGCTGCTGCGGCGCTTGGACCGAGAGGAGGCGGCGGCGCACCGGCTGCAGATCGAGGCATGGGACGGCGGCCGACCCCGGCGCACCGGCCTCCT
GAGCGTGGAGCTGCGCGTGCTGGATGAGAACGACAACCCGCCGGTCTTTGAGCAGGACGAGTACCGCGCCGCGGTGCGCGAGGACGCCCAGCCGGGCGCC
GAGGTCTGTCGCGTGCGCGCCACCGACCGCGACCTGGGGCCCAATGGCTTCGTGCGCTACAGCGTCCGCGCCCGGCAAGTGCCTGGGGCGGGTAGCGGCG
GCGGGGCACTGGGCGACGCGGCCTACTTCGCGGTGGAGGAGCTGAGCGGCGTGGTGCGAGTGTGGAGACCTCTGGACCGCGAGGCACAGGCCTGGCACCA
GTTGGTGGTGGAGGCCCGCGATGGAGGCGCCGAGCCTGAGGTTGCCACGGTGCGCGTGTCCATCGCCGTGCTGGACGTGAATGACAACCGGCCAGCAATT
CACGTGCTCTTTCTCACAGAGGGAGGCGTCGCCCGTGTCTCTGAAGGCGCCCGACCGGGCGACTACGTGGCTCGCGTCTCGGTGTCTGACGCGGACGGTG
ACTGGGAGAAGGAAGATGAGGCCACAGGGGAGCTTGGTGTGGGTCTTGGAGACGGGAGCATCTCTCTGTCCTTGGAAGGCGGAGAGGGAGACTTCGCGTT
GCTACCCGGCGGCCCCCCAGGGGTATTTTTCCTTTGCGTGGAGGGGCCCCTGGACAGAGAGAGCCGCGATCTGTATGAGTTACTACTGGTGGCCACGGAC
GCGGGGTCCCCGCCGCTGAGCACGGAGGAGACGCTGCTACTCCGGGTCGCTGACCTCAATGACCAACCACCTCTCTTCAGCCAACAGCATTACAAGGCCT
CAGTGTCCGAGGCCGCGGCCCCTGGCACTGTAGTCATGTGGGTCAGCGCCTCCGATGCCGACGAGGCAGGCAGTGATCACGCCTGGCTGCGCTACACTGT
AGTCCAACTCTCGGCTCCCTGCAATCTCGGCTCCCTGCAATCAAAGATGGTCCACACCGCAGAGTGTGGACCATCTTTTGCCATTGATTCCGAAAGCGGT
GCGATCAGCACTATCCGGACTCTAGACCGAGAGGTCCAGGAGGCGGTGGAGCTGAAAGTGGTGGCCCAGGACCTCGGAGAGCCCCCACTCTCTGCCACCT
GCCTGGTGAGCATCACCGTAGATGATGTGAATGACAATGAGCCCATCTTCTGGAGGCAGGTGTACAATGCCACCATTGCAGAGCATGCCCCGGTTGGACA
CTGCTTTCTGCAGGTGACAGCCTCTGATGCAGATTCAGGACTCTATGGCTTTATTGAATATTCTCTTTATGATGGATTCCTGAGCTATGAAGCACCTCAG
GCATTCCGGATCGACCCTCATGATGGGCAAATCTGTGTTTCTCAAGATATCGACAGGGAAAGGGATCCAGCTACCTATGATCTCCTGGTGGAAGCTAAGG
ATGGGGGTGGGCTAAGTGCCCAAGCCTTTGTTCGTGTGGACCTGGAGGACGTGAATGATAATCATCCTGTGTTTAACCCATCAACCTATGTGACGAGCAT
CAGTGATGAGACCCAGCCAGGCACCGAGATCATCAATGTTCTTGCCACTGACCAGGACTCTGGGATATATGGGACAGTGGCTTATGAGCTTATTCCAGGA
AACGTGTCGTCCCTTTTTACCATTGACTCCACCACAGGAATTATTTACTTAACATTACCTCTTAGTCATTTGGAATCTACCACACTTTCGTTGATGGTCT
CTGCTCAAGACGGTGGTGGGCTCACAGCTGTCATTAATGCCGATGTCACCATACACATTTTCCAGACAACTCTGGCACCTGCTGAGTTTGAAAGGCCTAA
GTACACTTTCTTAGTTTATGAAGATGTGCCTGAAGATAGTCCCATTGGAACAGTGAAAGCAAGAGAGCCCTTGAACTCCTCAGAACCAATCTTTTACAGG
ATTTCTTCTGGTGATCTCGGCGGAAAGTTCTCCATTCACCCGCGGCTGGGCACTATTCGCACCCGGAAGCCCCTGGATCACGAGACGCAGCCCGTGGTTG
TGCTCACGGTGCAGGCGCAGCTCGGCAGCGCCCCAGCCTGCAGCAGCACCGAGGTCAACATAACAGTCATGGATGTCAATGACAACCACCCAGCGTTCCT
CAGGACCTCGGATGAGATTAGAATATCCCAGACCACGCCCCCTGGCACAGCCTTGTACCTCGCACGTGCGGAAGACAGAGACAGTGGGCGGAACGGACTC
ATCCGGTACTCCATCGCCAGCCCGCAGCCAGGCGTCTTTGCCATCGACAGAGCCCTGGGGGTGCTGTTCCTCAACGGCAGCCTGGGCGCGGGCGAGCAGC
GGGAGCTCACGCTGACTCTCAGGGCCGAGGACCAAGGCGTGCATCCTCAGGCAGCCCTGCTGGTGCTGACAGTCGTTATCGAGAAACGCGAACACAGCCC
ATCCTGGACTTTCGAACATTTGGTCTATCAAGTGGAAGTCAGTGAGTCTCTCTCACCGATGACACAAATGCTGCAAACACAGGCGCACCCACTTGGCCCC
CAGCGTGCAGCCTCGCCTCTTAGGTACTCGCTGGAACCCAGCGTAGACTCTGCTATGTTTGGAATCCGCCCTTACACGGGCTGGATTTATTTGCGGCGAC
AGTTTGACTATGAATCCACCCAAACATATAATTTTAGAGTGTTTGCTTGGATCCCCGAGGACGGATTCTTGCAAAATGTGAGCACTACAGTCATTGTTCG
TGTCTGGGATGAGAATGACAATTCCCCCACCTTCTTGCATGATGTGTTGTTTTTGAAAGTCGAAGAGAGCCCTGTTCCCCAAGGGGTAATAGGCAAAATT
ACAGCTATTGACATGGACTCTGGAAAGAATGGACAGCTATTATATTTCCTTTTGTCTGATGGAAAATTCTTCAAGATGAATCCTAATACAGGAGAGTTAA
TCAATTGGGTGGCACTGGATCGTGAGCACCGGGGGCACCATGAGATGACTGTGCTAGTGACAGACCGCGGCTCCCCACCACGAAACGCCACCATGGCGGT
TTACGTCTCAGTTACTGACATCAATGATAACAGGCCCTTCTTCCCCCAGTGTCTCCCTGGAAAGGAGTTACACGTGAAGGTTCTGGAAGGTCAACCAGTA
AATATGTTGGTTACAACTGTGTTTGCAAAGGATCCTGATGAAGGAAATAATGCAGAAGTTACATACTCAGTATCTTCAGCTAGACCTATGCCTCTGAAGG
GAAAAACAGCATTTGGGAAGCAGTCGTGCAAAAAACAAACAAACAAACAAACAAACAAAATCCTGACCTGAATCTGGTCAGTTCTCTAGATCTGCCTCCC
AATTTAAGGAAAACATAAGAATAGAGGAACATATTATGCTACACGTTGGAGATGCAACAGCAAATCTAGATCATGGAAAATGTCAGGATACAAGTTCCAG
TTTATTCAACAAATAAATTGCAAGGACAAATAGAGAGATGGGTGGCAGGAATCCATAGATTAAAGAAATATGCAATATATGGACTTTATTTTGATCTTAA
TGTAAACAAGAAAAATAAAGAGTATTTATGGGATGGTTGAAAATTTGAAAACTTACTGAATATTTGGTGATACTGTGAACCATTATTAATTTTTAAGGTA
TAATATGGTACTGTGATGATTGTGTTAAAATATTTATTTTTTAAAGATGCATTTTGAAATATATACAGAAGAAATAATATGACTTCTGGAACTTACTTCA
AAAAAAATGGGAGAAGCGAAGTATATACATGGGGAATAGATGAAATAAGATTGGCCATGAGCTGATCATTGTTGAAGCTAGGTGATGGACTCGTGAAAGT
TTATTATACCATTTTGTCCACTTTTTTGTATGCATTTTCCATAATAAAAATTTTT
  • refseq_DCHS2.F6 (forward primer)
  • refseq_DCHS2.R6 (reverse primer)
  • Single exon skipping

Frame 0

NNAPDFTRGEQPAE*NKEQM*RE*KEREKEMRF
V*RNPGAEEVAAAAEAARAYFPVCVSCRQRTLSP
VADVTSGIPGPSVCLPNKVFSSLAQTLKRLLDF
SAILPQAGSYPRAFPRSWRRNEPLWAEDGRRAS
AAAGSGREAPSAPREERYTPWAVRQQRRQDAALP
ALALGARVAVGGLGLLCPVVQPHPFRR*GASPG
HAGR*HPRRAAGRAAAGGERLLSVGGLR*LPAA
GRLPRAPGHRHHPHCAAPGPRAAGPLQLRRRHAA
GRCGAGGDSRQRRE*PLAPLSPRLPATRRLRAQ
PARDRLPPASCPRSGRRTVQHSGLHPGATVRPA
QGPRRPVLPVALPDSGATTVTAFARLLVTPGASR
SGAAAALGPRGGGGAPAADRGMGRRPTPAHRPP
ERGAARAG*ERQPAGL*AGRVPRRGARGRPAGR
RGLSRARHRPRPGAQWLRALQRPRPASAWGG*RR
RGTGRRGLLRGGGAERRGASVETSGPRGTGLAP
VGGGGPRWRRRA*GCHGARVHRRAGRE*QPASN
SRALSHRGRRRPCL*RRPTGRLRGSRLGV*RGR*
LGEGR*GHRGAWCGSWRREHLSVLGRRRGRLRV
ATRRPPRGIFPLRGGAPGQREPRSV*VTTGGHG
RGVPAAEHGGDAATPGR*PQ*PTTSLQPTALQGL
SVRGRGPWHCSHVGQRLRCRRGRQ*SRLAALHC
SPTLGSLQSRLPAIKDGPHRRVWTIFCH*FRKR
CDQHYPDSRPRGPGGGGAESGGPGPRRAPTLCHL
PGEHHRR*CE*Q*AHLLEAGVQCHHCRACPGWT
LLSAGDSL*CRFRTLWLY*IFSL*WIPEL*STS
GIPDRPS*WANLCFSRYRQGKGSSYL*SPGGS*G
WGWAKCPSLCSCGPGGRE**SSCV*PINLCDEH
Q**DPARHRDHQCSCH*PGLWDIWDSGL*AYSR
KRVVPFYH*LHHRNYLLNITS*SFGIYHTFVDGL
CSRRWWAHSCH*CRCHHTHFPDNSGTC*V*KA*
VHFLSL*RCA*R*SHWNSESKRALELLRTNLLQ
DFFW*SRRKVLHSPAAGHYSHPEAPGSRDAARGC
AHGAGAARQRPSLQQHRGQHNSHGCQ*QPPSVP
QDLG*D*NIPDHAPWHSLVPRTCGRQRQWAERT
HPVLHRQPAARRLCHRQSPGGAVPQRQPGRGRAA
GAHADSQGRGPRRASSGSPAGADSRYRETRTQP
ILDFRTFGLSSGSQ*VSLTDDTNAANTGAPTWP
PACSLAS*VLAGTQRRLCYVWNPPLHGLDLFAAT
V*L*IHPNI*F*SVCLDPRGRILAKCEHYSHCS
CLG*E*QFPHLLA*CVVFESRREPCSPRGNRQN
YSY*HGLWKEWTAIIFPFV*WKILQDES*YRRVN
QLGGTGS*APGAP*DDCASDRPRLPTTKRHHGG
LRLSY*HQ**QALLPPVSPWKGVTREGSGRSTS
KYVGYNCVCKGS**RK*CRSYILSIFS*TYASEG
KNSIWEAVVQKTNKQTNKQNPDLNLVSSLDLPP
NLRKT*E*RNILCYTLEMQQQI*IMENVRIQVP
VYSTNKLQGQIERWVAGIHRLKKYAIYGLYFDLN
VNKKNKEYLWDG*KFENLLNIW*YCEPLLIFKV
*YGTVMIVLKYLFFKDAF*NIYRRNNMTSGTYF
KKNGRSEVYTWGIDEIRLAMS*SLLKLGDGLVKV
YYTILSTFLYAFSIIKIF

Frame 1

IMHLTLPGGNNQPSRTRNRCKGNKRREKKR*DS
FKEIQGQKRWLPRQRQLELTSLSA*AAGRGRFH
QLQM*PREFLGRRFVCQTKSFLLWLRH*RGSWIF
LRSCHKLAVTREPSQGAGGEMSPCGRKMGEGRQ
QRRAPVGKLLLLPGRRDTPHGRSGSSGARTQRS
LLWLLVHVWLWAASGSSAQLFNLTLSVDEGLPPD
TLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLL
DDFHVHPDTGIIRTARRLDRERRDHYSFVAATL
LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELS
PPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLP
KDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPL
DLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLL
SVELRVLDENDNPPVFEQDEYRAAVREDAQPGA
EVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG
GGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQ
LVVEARDGGAEPEVATVRVSIAVLDVNDNRPAI
HVLFLTEGGVARVSEGARPGDYVARVSVSDADG
DWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL
LPGGPPGVFFLCVEGPLDRESRDLYELLLVATD
AGSPPLSTEETLLLRVADLNDQPPLFSQQHYKA
SVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTV
VQLSAPCNLGSLQSKMVHTAECGPSFAIDSESG
AISTIRTLDREVQEAVELKVVAQDLGEPPLSAT
CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGH
CFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQ
AFRIDPHDGQICVSQDIDRERDPATYDLLVEAK
DGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSI
SDETQPGTEIINVLATDQDSGIYGTVAYELIPG
NVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMV
SAQDGGGLTAVINADVTIHIFQTTLAPAEFERPK
YTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYR
ISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVV
VLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFL
RTSDEIRISQTTPPGTALYLARAEDRDSGRNGL
IRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQ
RELTLTLRAEDQGVHPQAALLVLTVVIEKREHSP
SWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGP
QRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRR
QFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVR
VWDENDNSPTFLHDVLFLKVEESPVPQGVIGKI
TAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGEL
INWVALDREHRGHHEMTVLVTDRGSPPRNATMAV
YVSVTDINDNRPFFPQCLPGKELHVKVLEGQPV
NMLVTTVFAKDPDEGNNAEVTYSVSSARPMPLK
GKTAFGKQSCKKQTNKQTNKILT*IWSVL*ICLP
I*GKHKNRGTYYATRWRCNSKSRSWKMSGYKFQ
FIQQINCKDK*RDGWQESID*RNMQYMDFILIL
M*TRKIKSIYGMVENLKTY*IFGDTVNHY*FLRY
NMVL**LC*NIYFLKMHFEIYTEEII*LLELTS
KKMGEAKYIHGE*MK*DWP*ADHC*S*VMDS*K
FIIPFCPLFCMHFP**KF

Frame 2

*CT*LYQGGTTSRVEQGTDVKGIKGERKRDEIR
LKKSRGRRGGCRGRGS*SLLPCLRELQAEDAFT
SCRCNLGNSWAVGLFAKQSLFFSGSDTEEAPGF
FCDPATSWQLPESLPKELEEK*ALVGGRWAKGVS
SGGLRSGSSFCSPGGEIHPMGGQAAAAPGRSAP
CSGSWCTCGCGRPRAPLPSCSTSPFP*MRGFPR
TRW*VTSAPGCRPRSSRRGAASFCRRTPMTPRCW
TTSTCTRTPASSALRGAWTASGGTTTASSPPRC
WALWCRWRFASTT*MTTRPAFPSTPCNSTSPSS
ARQGPPSACQLPTIRTPDCSALRATPWCNRPTCP
RTPQARSSSCATGLRGHYRHRFCQAPRHPWSL*
IWCCCGAWTERRRRRTGCRSRHGTAADPGAPAS
*AWSCACWMRTTTRRSLSRTSTAPRCARTPSRAP
RSVACAPPTATWGPMASCATASAPGKCLGRVAA
AGHWATRPTSRWRS*AAWCECGDLWTARHRPGT
SWWWRPAMEAPSLRLPRCACPSPCWT*MTTGQQF
TCSFSQREASPVSLKAPDRATTWLASRCLTRTV
TGRRKMRPQGSLVWVLETGASLCPWKAERETSR
CYPAAPQGYFSFAWRGPWTERAAICMSYYWWPRT
RGPRR*ARRRRCYSGSLTSMTNHLSSANSITRP
QCPRPRPLAL*SCGSAPPMPTRQAVITPGCATL
*SNSRLPAISAPCNQRWSTPQSVDHLLPLIPKAV
RSALSGL*TERSRRRWS*KWWPRTSESPHSLPP
AW*ASP*MM*MTMSPSSGGRCTMPPLQSMPRLD
TAFCR*QPLMQIQDSMALLNILFMMDS*AMKHLR
HSGSTLMMGKSVFLKISTGKGIQLPMISWWKLR
MGVG*VPKPLFVWTWRT*MIIILCLTHQPM*RA
SVMRPSQAPRSSMFLPLTRTLGYMGQWLMSLFQE
TCRPFLPLTPPQELFT*HYLLVIWNLPHFR*WS
LLKTVVGSQLSLMPMSPYTFSRQLWHLLSLKGL
STLS*FMKMCLKIVPLEQ*KQESP*TPQNQSFTG
FLLVISAESSPFTRGWALFAPGSPWITRRSPWL
CSRCRRSSAAPQPAAAPRST*QSWMSMTTTQRS
SGPRMRLEYPRPRPLAQPCTSHVRKTETVGGTDS
SGTPSPARSQASLPSTEPWGCCSSTAAWARASS
GSSR*LSGPRTKACILRQPCWC*QSLSRNANTA
HPGLSNIWSIKWKSVSLSHR*HKCCKHRRTHLAP
SVQPRLLGTRWNPA*TLLCLESALTRAGFICGD
SLTMNPPKHIILECLLGSPRTDSCKM*ALQSLF
VSGMRMTIPPPSCMMCCF*KSKRALFPKG**AKL
QLLTWTLERMDSYYISFCLMENSSR*ILIQES*
SIGWHWIVSTGGTMR*LC**QTAAPHHETPPWR
FTSQLLTSMITGPSSPSVSLERSYT*RFWKVNQ*
ICWLQLCLQRILMKEIMQKLHTQYLQLDLCL*R
EKQHLGSSRAKNKQTNKQTKS*PESGQFSRSAS
QFKENIRIEEHIMLHVGDATANLDHGKCQDTSSS
LFNK*IARTNREMGGRNP*IKEICNIWTLF*S*
CKQEK*RVFMGWLKI*KLTEYLVIL*TIINF*G
IIWYCDDCVKIFIF*RCILKYIQKK*YDFWNLLQ
KKWEKRSIYMGNR*NKIGHELIIVEAR*WTRES
LLYHFVHFFVCIFHNKNF

Sequence NM_017639

ATGAGACTGGATGAGATAACGAAATCAGAGAATGAAGACGGAGAAAAGAAGATGTTTACTCAGCAGTTTGAAAGTACTGATGCCTGTGTATATGAGGTGT
ATGTGAAAATAAATTCCATTGTGAAATCTCAGAGTCAGTGTGGATTGAAAAGAGGTAGTCCCGAGACTGAGCTCTGGGGTGCTATAGTGTTCAGAAGCCA
GGAAGAGAACGCAAAACCAGTGAAGGAAACTGAGGTGACAGCCTCTGATGCAGATTCAGGACTCTATGGCTTTATTGAATATTCTCTTTATGATGGATTC
CTGAGCTATGAAGCACCTCAGGCATTCCGGATCGACCCTCATGATGGGCAAATCTGTGTTTCTCAAGATATCGACAGGGAAAGGGATCCAGCTACCTATG
ATCTCCTGGTGGAAGCTAAGGATGGGGATGAGCAGAGAATGACACATTTAGCCCTGGTGAAGGGTGGGCTAAGTGCCCAAGCCTTTGTTCGTGTGGACCT
GGAGGACGTGAATGATAATCATCCTGTGTTTAACCCATCAACCTATGTGACGAGCATCAGTGATGAGACCCAGCCAGGCACCGAGATCATCAATGTTCTT
GCCACTGACCAGGACTCTGGGATATATGGGACAGTGGCTTATGAGCTTATTCCAGGAAACGTGTCGTCCCTTTTTACCATTGACTCCACCACAGGACTCT
ATAGTCCAGAGGTAGAAATTCTGAGTGCTGTCAACTTTTCAGCAGACAAGGAAGTAATGAACAGTTTAGAGATGTTTTTACCTCTGCTAAGGCACTTCAA
GAAGGTTGAAAGAGATGAGGAAGCTGCAGAAAAAAAATTTGAAGCTAGCAGAGGTTGGTTCATGAGGTTTAAGGGAAGACGCCATCTCCATTACCTAAAA
GTGCAAGATGAAGCAGCAAGTGCTGATGGAGAAGCTGCAGCAAGGTATGTAGCAAATCTAGCTAAGATTCTTGGTGAAGGAATTATTTACTTAACATTAC
CTCTTAGTCATTTGGAATCTACCACACTTTCGTTGATGGTCTCTGCTCAAGACGGTGGTGGGCTCACAGCTGTCATTAATGCCGATGTCACCATACACAT
TTTCCAGACAACTCTGGCACCTGCTGAGTTTGAAAGGCCTAAGTACACTTTCTTAGTTTATGAAGATGTGCCTGAAGATAGTCCCATTGGAACAGTGAAA
GCAAGAGAGCCCTTGAACTCCTCAGAACCAATCTTTTACAGGATTTCTTCTGGTGATCTCGGCGGAAAGTTCTCCATTCACCCGCGGCTGGGCACTATTC
GCACCCGGAAGCCCCTGGATCACGAGACGCAGCCCGTGGTTGTGCTCACGGTGCAGGCGCAGCTCGGCAGCGCCCCAGCCTGCAGCAGCACCGAGGTCAA
CATAACAGTCATGGATGTCAATGACAACCACCCAGCGTTCCTCAGGACCTCGGATGAGATTAGAATATCCCAGACCACGCCCCCTGGCACAGCCTTGTAC
CTCGCACGTGCGGAAGACAGAGACAGTGGGCGGAACGGACTCATCCGGTACTCCATCGCCAGCCCGCAGCCAGGCGTCTTTGCCATCGACAGAGCCCTGG
GGGTGCTGTTCCTCAACGGCAGCCTGGGCGCGGGCGAGCAGCGGGAGCTCACGCTGACTCTCAGGGCCGAGGACCAAGGCGTGCATCCTCAGGCAGCCCT
GCTGGTGCTGACAGTCGTTATCGAGAAACGCGAACACAGCCCATCCTGGACTTTCGAACATTTGGTCTATCAAGTGGAAGTCAGTGAGTCTCTCTCACCG
ATGACACAAATGCTGCAAACACAGGCGCACCCACTTGGCCCCCAGCGTGCAGCCTCGCCTCTTAGGTACTCGCTGGAACCCAGCGTAGACTCTGCTATGT
TTGGAATCCGCCCTTACACGGGCTGGATTTATTTGCGGCGACAGTTTGACTATGAATCCACCCAAACATATAATTTTAGAGTGTTTGCTTGGATCCCCGA
GGACGGATTCTTGCAAAATGTGAGCACTACAGTCATTGTTCGTGTCTGGGATGAGAATGACAATTCCCCCACCTTCTTGCATGATGTGTTGTTTTTGAAA
GTCGAAGAGAGCCCTGTTCCCCAAGGGGTAATAGGCAAAATTACAGCTATTGACATGGACTCTGGAAAGAATGGACAGCTATTATATTTCCTTTTGTCTG
ATGGAAAATTCTTCAAGATGAATCCTAATACAGGTCCAGCAGGCACCATCTATGTCATAACCTGGGCAGATGGTGCTGCTGCCTTTAGTGGGACAGACTT
TGCATTCAGTTCTGATGAACTTCAAGCCTTTGTTCTCAAGTCTCTGTTCTGTGAATTAGGAGAAGGAGAGTTAATCAATTGGGTGGCACTGGATCGTGAG
CACCGGGGGCACCATGAGATGACTGTGCTAGTGACAGACCGCGGCTCCCCACCACGAAACGCCACCATGGCGGTTTACGTCTCAGTTACTGACATCAATG
ATAACAGGCCCTTCTTCCCCCAGTGTCTCCCTGGAAAGGAGTTACACGTGAAGGTTCTGGAAGGTCAACCAGTAAATATGTTGGTTACAACTGTGTTTGC
AAAGGATCCTGATGAAGGAAATAATGCAGAAGTTACATACTCAGTATCTTCAGAAGATAGTTCTGATCACTTTAAGATTGACGCCAACAATGGTGAAATA
AGAACAACCACAATACTTTCGTATGATTATAGACCTTCCTACAGAATGAGTGTCATTGCCACTGACCAGGGAGTGCCTCCTCTTCAAGGACAGGCAGTTG
TTAATATTCAGGTGATCCCACTATCCAAAGGGAGAGCAATCATGTCTCAGAATATTAGACATTTAATTATACCAGAAAATTTGAAGCCCACAAAAATAAT
GAGCTTGATAAAGTCATCTGATCACCTTCAACAACATTATAATGGAAAGTTACATTTTAGTATTGTTGCAGATGATAAGGATGGACACTTTGAAATAGAC
AGCTCAACCGGAGACTTGTTTCTTTCTAAGGAACTTGATTATGAGACGACATCTCATTATCTTTTCAGAGTGATTACTACAGACCATAGCAAAAACCTTT
CCCTGAGTAGCACAGTCTTCCTTAGTATCGATGTGGAAGATCAGAATGACCATTCCCCATCTTTCCAGGATGAGCTCATTGTGATCAGTGTAGAGGAGAA
TGTTCCCATAGGAACCCTGGTGTATGTCTTCAATGCCAAAGATGATGACGGCAGTTTTTTGAACAGTAGAATACAATACTACATTGAATCCCACAACCCT
GGCACGAATCCATTTCTCATCCACCCCTCATTTGGCACACTAGTCACTGTGTCCCGTCTTGACAGAGAAAGCATTCCAACTGTCATCCTGACAGTAACAG
CATCTGATCAGGCTGTGAATGTGACAGACCGGCGACTGAGATCACTGACAGCACAAATAGTGATTTTGGATGTAAATGACCACAACCCCACTTTTATTTC
TTTCCCCAATGCCCATGTCAAAGAGGATGTCACAGTGGGCTCCTTGGTCCACCACATAACTGCTCACGATCCAGACGAAGGAAGGAATGGAAAAGTAACA
TACAGCATCCTCTCAGGAAATGAAAACATGACGTTTATGCTAGATGAGTCATCAGGCTTACTAACCACAACCTGTCCTTTGGATTATGAAATGAAAACTC
AGCATATTCTGACTGTTCTGGCACTGGATGATGGCACACCAGCACTTTCTTCATCCCAGACTTTGACAGTTACTGTTCTTGATGTAAATGATGAAGCTCC
AGTATTTAAGCAGCACCTGTATGAAGCCTCAGTGAAAGAAAACCAAAATCCAGGGGAGTTTGTTACCAGGGTTGAAGCTCTGGACAGAGATTCAGGAGTC
AATTCCAAGCTTCAGTTTGAAATCATGCCAGGTGCTTCATTTGAATTATTCGAGATAAATTCTGACACTGGAGAGGTAGTGACAACCACCATACTTGACA
GAGAAATTCAAGAAGTCTTCACCCTTCGAGTACTAGTACGAGATGGGGGATTCCCTTCATTGTCCAGCACCACAACAATCCTCTGCACTGTTGAAGATGA
AAACGATCACGCACCAGAGTTTATTGTTTCCAGTTATGACATTGAGGTTCTGGAAAACCAGGAACCAGAGGTTGTCTATACGGTTTTAGCCTCTGATATG
GATGCTGGCAATAACAGAGCTGTTGAATATCACATAATTGATGGAAATACTGATGAGTGCTTTACTATAAATGAGATGTCAGGAGAACTCTCAACCACTC
GTGCTTTGGACCGGGAGCAAATCAGCAATTTTACCCTTGTCATTCTGTGCTCTGACCTGGGAGATCCACCTAGGAGCTCTGTAATACACCTGCAAGTTAG
AGTTTTGGATGCCAATGACCACAGTCCTTCTTTTCCCACACTTTATTACCAGTCCTCTGTGAGAGAAGATGCTGAAGTGGGAACAGTGGTTCTTGTGCTT
TCAGCTGTGGACAAGGATGAAGGCCTGAATGGGCAAACTGAGTATTTTCTGACTGATGAGGCTTCTGGTGCATTCACCATTGATCCTATGTCAGGCACAT
TGAAAACCAGCAACACCCTCGACCGTGAAGCCAGATCTCAGCATACATTTAGTGCTGTGGCCAGAGACTGTAGCATCCAGGGTTCACGAAGCACCACTGT
AATTATAAAAGTATATGTCACTGATGTTAATGACAATGATCCAGTTTTGGAACAGAACCCTTTTGATGTGTTTCTTTCCCCCGAGTCGCCTACAAACCAG
ACAACTGTCATTGTGAGAGCTGATGACCTGGACTTGGGGCCCAATGGAACTGTGGTTTTTAGTTTTGCAGAGACCCAGTCAATGTTTTCTATTGATAAAT
ACACAGGAGAAATTCAATTTCAGCAAAATCCATCTTCAGAATACTTCCCTATCTGGCTGCAGTTAAAAGTTACAGACCAGGGCATTCCAGCCAGGACAAC
CACGGGTCTCTTGGTCATTCACATGGAAGGAGAAGATGTAAAGATTTCCTTCAGCCACCACCTGTATAAAGGGCTCGTGACTGAAAATTGTGAGGCAGGT
ACTTCTATTGTGACTGTTAAAGCTTTTGCTCCTGACTCAATTCAGGACAGCATGAAATATTCAATTTTTAGTGGAAATGAAGATGGAGTTCTTTCCCTGT
GCTCTAAGTCAGGACAACTCACTGTGAAAGAACCCAAGTTTCTTGATTTTGAAGTCAGAAATGAGGTTCAACTCATCGTTTTAGCTGAAAGTAGTGGGCA
TAGAGCCTATTGCAAAGTAGCAGTCTTGATACAGGATGAGAATGATAATTCACCATGCTTTGAACAAAGCATTTACCAGGCATCAGTGTCTGAAAGCCAA
CTCTACAATGCTCATGTCATACAGGTTTTTGCTACCGACTTGGACAGTGGTTTGAACGGCCTGATTGAGTATTCTATTCTGTCTGGCAACCAAGAAGAAG
CATTCCAGATTGATGCACTGAGTGGTGTGATAACAACAAAAGCGATTCTAGATTACGAGCTCACCAGCTCCTACAGCTTGATTGTCCAAGCCACAGATAA
AGGGATGCCCAGGCTTTCTAATACGACTGTAATCAAGGTACAGGTGACTGATATAAATGACAATGCCCCAGCTTTTCTCCCCTCTGAAGCAGTGGAAATT
ACAGAAGATTCTTTGCCTGGTGTAATTGTGACTCATGTGTCAGTTCATGATGTGGATTTGAATTCAGCTTTCATATTCAGTTTTGCCAAAGAGAGTAATC
CTGGAACCAAGTTTGCTATTGATCAGAACACTGGAGTGGTGGTGTTGGTGAAAACATTGGATTTTGAAGAAATGACTGAATATGAGCTGCTCATCCAAAT
TTCTGATTCAGTGCACTACACAGAGGGAGCACTTGTAGTCCGTGTGCTGGATGTCAATGATAATCCACCAGTGTTTTCTCAAGATTTCTATCAGGTCACA
GTTCCTGAATCAATACCTGTGGGGTATTCAGTGCTGACTCTGTCAGCCACAGACTTAGAAAGCAATGAGAACATTTCTTACAGAATTCTATCCTCTTCTA
AGGAATTCTCCATTGATCCTAAGAATGGCACAATATTTACTATCAGTCCCGTATTACTTCTGGATACAATATCAACAACTCAATTTCTTGTGGAAGCCAG
TGATGGTGGAAATCCTGACCTGAGAGCTCTTACTTTAGTGGAGATAGGAATAGAAGATATGAACAATTATGCCCCTGAATTCACAGTCAAATCCTATAAT
CTTAGCCTAAGTGAGGATGCTCTGGTTGGAAGCACGCTTGTTACATTTTCAAACATCGACCATGACTGGACCCGTGAAAACACATATGTTGAATATTCCA
TCATCAGTGGTAATTCACAGAACAATTTTCATGTGGAAACTAAGTTCTTTCATTCAGAATATCCTTATAAGCAAGTCGGTTATCTTGTGTTGCTTCACAG
TCTGGACAGAGAAGCAAGTGCTAGCCATGAGCTTGTCATTCTGGCATCTGACAGTGGCTGCCCTCCATTGAGTTCCACAGCTGTCATATCAATACAAGTA
CTTGATGTCAATGACAATCCCCCAAACTTCAGCAGCCTGAGCTATCACACCCATGTCAAGGAAAGCACCCCTCTAGGGAGTCACATCACTGTGGTCTCAG
CAAATGACCGTGACACAGGGTCACATGCAGAAATCATCTACAACATCATCTCTGGAAATGAGAAGGGACATTTTTACTTAGAAGAAAACACTGGAGTTCT
TTATTTGATTAAACCTCTGGATTATGAAAAAATGACAAAATTCACCTTAACTGTCCAAGCTTCAGATGCAGAAAAGAAACATTTTTCTTTTGCAGTTGTG
TTTGTCAGTGTCCTGGATGATAACGACCATGCACCTCAGTTTATGTTCTCAAGCTTCAGCTGTATTGTTCCAGAAAATCTGCCTATTTCCTCTACCATAT
GCTCTATAAATGCTCTGGATTTTGATGCTGGTCCGTATGGAGAATTGACCTATTCTATTGTATCACCCTGTTTTCTCACTCATGGAATGTCTTATGATCA
TGATCTCTTCCTCATTGACCCTTTGACAGGGGATATTCATGCTAAGCAAATCCTTGACTATGAAAATGGCAATAAATACTGCCTCACAGTCCAAGCCAAA
GACAAAGGTGATGCAACTGCCTCCTTAGTGGTCTGGGTGGATATTGAAGGGATAGATGAATTTGAGCCCATTTTCACTCAAGATCAGTATTTTTTCACCC
TCCCAGAAAAGAATAAAGACAGACAGTTGATTGGCAGAGTGGAAGCCTCAGATGCAGATGCTGGTATTGATGGAGTCATTCTTTACTCCCTTGGAACCTC
ATCTCCTTTCTTTTCAGTAAATAAAACCAATGGAAATATTTATTTGATTAGAGCCCTTCCCCTAATAAAAAGTCAACTCAACAAAGAAGACACCTTGGAA
ATGAAAATAATCGCTCATAGTCCCAAATCAGATTCCAAGTTTGCATCTTGCACTGTTTTTGTGAATGTGTCTTTCTCCTCTGAAGGAACACCCTTGGCAG
TGTTCGCCAGCAGCTTTTCAATCAGCCTGGTGGTCTCCTTTTTAGTGTTTCTGATACTCATCTGCATTCTAATTGTAATGATTTTAAGACATAAACAAAA
AGACACAATAAACAATTATGAGGAGAAGAAAACCTCATCTTTAGATGCGGACTTGAGAGTGACCCGGGATGCCAGTGTGCTCAAAGCCTTCCAGAAAACT
GACGACTGCAGTAACGAGGTGGTCCCTGTGGATGCCACTCCGGAATGGTTGAGTTTAATAAGTATCATGGAGAAGGATATTGTCAATCTGTACAGACACT
CAAACTCCAGTGGCCACTGTTCTGTGGAAGGAGAAACTGCAGAAGATAAGGAAATCCAGAGGATAAATGAGCATCCCTACAGAAAGTGCTCAGACTCAGC
TCTGAGTGACCACGAGTCCAGGGTGCCAGACTCGGGTATCCCGAGGGACTCAGACCAGCTCTCCTGCCTATCTGGGGAAACTGATGTGATGGTGACTGCC
GAAACAGCAGAAGCCAGCCAAACATTTGGGGAAGGAGATCAAGGGGAAGGCTGCAGCACCACCTGTGCTCAAAATAATGTGTTACCCCAGACAGTTCAGA
AGAGAGAGGCAAAAGAGAGCATCCTGGCTGACGTTAGAAAAGAGTCTGTCTTTATTTCAGGTGATCAGGAAGTAAGGTGTGCAGCTCTTTCAACTCAGAC
GACCTCTGATCATGATGGAAAAGACAACTATCACTGGAATTATCTTCTTAGTTGGGAGCCCAAATTCCAACCTCTTGCCTCAGTATTTAATGATATTGCA
AAACTAAAGGATGAACATTTGCATATGCCTGGCATTCCAAAAGAGAAGAAATCTTTTGTTTTTCCACCCCCTTTGATAACAGCAGTAGCCCAGCCTGGGA
TTAAAGCAGTCCCACCAAGAATGCCGGCAGTAAACCTGGGGCAGGTGCCTCCGAAACACCCACGCTCTCCCATCCCCTACCATCTTGGTTCTCTGCCAGA
AGGCATGACTCCCAATTTTTCTCCATCTCTTTCCCTATTGACGATGCAGCCTCCTGCCTTGTCTCCACTGTTGAGAGAAGGAGAATTATTAGGAACACAC
ATCAGTGGTACATGCCATGAACTTAAAGCAGAAGATGAAGTTCAAATATGA
  • refseq_DCHS2.F6 (forward primer)
  • refseq_DCHS2.R6 (reverse primer)
  • Single exon skipping

Frame 0

MRLDEITKSENEDGEKKMFTQQFESTDACVYEV
YVKINSIVKSQSQCGLKRGSPETELWGAIVFRSQ
EENAKPVKETEVTASDADSGLYGFIEYSLYDGF
LSYEAPQAFRIDPHDGQICVSQDIDRERDPATY
DLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDL
EDVNDNHPVFNPSTYVTSISDETQPGTEIINVL
ATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL
YSPEVEILSAVNFSADKEVMNSLEMFLPLLRHFK
KVERDEEAAEKKFEASRGWFMRFKGRRHLHYLK
VQDEAASADGEAAARYVANLAKILGEGIIYLTL
PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHI
FQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK
AREPLNSSEPIFYRISSGDLGGKFSIHPRLGTI
RTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVN
ITVMDVNDNHPAFLRTSDEIRISQTTPPGTALY
LARAEDRDSGRNGLIRYSIASPQPGVFAIDRAL
GVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAAL
LVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP
MTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAM
FGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE
DGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLK
VEESPVPQGVIGKITAIDMDSGKNGQLLYFLLS
DGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDF
AFSSDELQAFVLKSLFCELGEGELINWVALDRE
HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDIN
DNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFA
KDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEI
RTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV
VNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIM
SLIKSSDHLQQHYNGKLHFSIVADDKDGHFEID
SSTGDLFLSKELDYETTSHYLFRVITTDHSKNL
SLSSTVFLSIDVEDQNDHSPSFQDELIVISVEEN
VPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNP
GTNPFLIHPSFGTLVTVSRLDRESIPTVILTVT
ASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFIS
FPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVT
YSILSGNENMTFMLDESSGLLTTTCPLDYEMKT
QHILTVLALDDGTPALSSSQTLTVTVLDVNDEAP
VFKQHLYEASVKENQNPGEFVTRVEALDRDSGV
NSKLQFEIMPGASFELFEINSDTGEVVTTTILD
REIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDE
NDHAPEFIVSSYDIEVLENQEPEVVYTVLASDM
DAGNNRAVEYHIIDGNTDECFTINEMSGELSTT
RALDREQISNFTLVILCSDLGDPPRSSVIHLQVR
VLDANDHSPSFPTLYYQSSVREDAEVGTVVLVL
SAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGT
LKTSNTLDREARSQHTFSAVARDCSIQGSRSTTV
IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQ
TTVIVRADDLDLGPNGTVVFSFAETQSMFSIDK
YTGEIQFQQNPSSEYFPIWLQLKVTDQGIPARTT
TGLLVIHMEGEDVKISFSHHLYKGLVTENCEAG
TSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSL
CSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGH
RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQ
LYNAHVIQVFATDLDSGLNGLIEYSILSGNQEE
AFQIDALSGVITTKAILDYELTSSYSLIVQATDK
GMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEI
TEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESN
PGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQI
SDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVT
VPESIPVGYSVLTLSATDLESNENISYRILSSS
KEFSIDPKNGTIFTISPVLLLDTISTTQFLVEAS
DGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYN
LSLSEDALVGSTLVTFSNIDHDWTRENTYVEYS
IISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHS
LDREASASHELVILASDSGCPPLSSTAVISIQV
LDVNDNPPNFSSLSYHTHVKESTPLGSHITVVS
ANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVL
YLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVV
FVSVLDDNDHAPQFMFSSFSCIVPENLPISSTI
CSINALDFDAGPYGELTYSIVSPCFLTHGMSYDH
DLFLIDPLTGDIHAKQILDYENGNKYCLTVQAK
DKGDATASLVVWVDIEGIDEFEPIFTQDQYFFT
LPEKNKDRQLIGRVEASDADAGIDGVILYSLGTS
SPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLE
MKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLA
VFASSFSISLVVSFLVFLILICILIVMILRHKQK
DTINNYEEKKTSSLDADLRVTRDASVLKAFQKT
DDCSNEVVPVDATPEWLSLISIMEKDIVNLYRH
SNSSGHCSVEGETAEDKEIQRINEHPYRKCSDSA
LSDHESRVPDSGIPRDSDQLSCLSGETDVMVTA
ETAEASQTFGEGDQGEGCSTTCAQNNVLPQTVQ
KREAKESILADVRKESVFISGDQEVRCAALSTQT
TSDHDGKDNYHWNYLLSWEPKFQPLASVFNDIA
KLKDEHLHMPGIPKEKKSFVFPPPLITAVAQPG
IKAVPPRMPAVNLGQVPPKHPRSPIPYHLGSLPE
GMTPNFSPSLSLLTMQPPALSPLLREGELLGTH
ISGTCHELKAEDEVQI*

Frame 1

*DWMR*RNQRMKTEKRRCLLSSLKVLMPVYMRC
M*K*IPL*NLRVSVD*KEVVPRLSSGVL*CSEA
RKRTQNQ*RKLR*QPLMQIQDSMALLNILFMMDS
*AMKHLRHSGSTLMMGKSVFLKISTGKGIQLPM
ISWWKLRMGMSRE*HI*PW*RVG*VPKPLFVWT
WRT*MIIILCLTHQPM*RASVMRPSQAPRSSMFL
PLTRTLGYMGQWLMSLFQETCRPFLPLTPPQDS
IVQR*KF*VLSTFQQTRK**TV*RCFYLC*GTS
RRLKEMRKLQKKNLKLAEVGS*GLREDAISIT*K
CKMKQQVLMEKLQQGM*QI*LRFLVKELFT*HY
LLVIWNLPHFR*WSLLKTVVGSQLSLMPMSPYT
FSRQLWHLLSLKGLSTLS*FMKMCLKIVPLEQ*K
QESP*TPQNQSFTGFLLVISAESSPFTRGWALF
APGSPWITRRSPWLCSRCRRSSAAPQPAAAPRS
T*QSWMSMTTTQRSSGPRMRLEYPRPRPLAQPCT
SHVRKTETVGGTDSSGTPSPARSQASLPSTEPW
GCCSSTAAWARASSGSSR*LSGPRTKACILRQP
CWC*QSLSRNANTAHPGLSNIWSIKWKSVSLSHR
*HKCCKHRRTHLAPSVQPRLLGTRWNPA*TLLC
LESALTRAGFICGDSLTMNPPKHIILECLLGSP
RTDSCKM*ALQSLFVSGMRMTIPPPSCMMCCF*K
SKRALFPKG**AKLQLLTWTLERMDSYYISFCL
MENSSR*ILIQVQQAPSMS*PGQMVLLPLVGQT
LHSVLMNFKPLFSSLCSVN*EKES*SIGWHWIVS
TGGTMR*LC**QTAAPHHETPPWRFTSQLLTSM
ITGPSSPSVSLERSYT*RFWKVNQ*ICWLQLCL
QRILMKEIMQKLHTQYLQKIVLITLRLTPTMVK*
EQPQYFRMIIDLPTE*VSLPLTRECLLFKDRQL
LIFR*SHYPKGEQSCLRILDI*LYQKI*SPQK*
*A**SHLITFNNIIMESYILVLLQMIRMDTLK*T
AQPETCFFLRNLIMRRHLIIFSE*LLQTIAKTF
P*VAQSSLVSMWKIRMTIPHLSRMSSL*SV*RR
MFP*EPWCMSSMPKMMTAVF*TVEYNTTLNPTTL
ARIHFSSTPHLAH*SLCPVLTEKAFQLSS*Q*Q
HLIRL*M*QTGD*DH*QHK**FWM*MTTTPLLF
LSPMPMSKRMSQWAPWSTT*LLTIQTKEGMEK*H
TASSQEMKT*RLC*MSHQAY*PQPVLWIMK*KL
SIF*LFWHWMMAHQHFLHPRL*QLLFLM*MMKL
QYLSSTCMKPQ*KKTKIQGSLLPGLKLWTEIQES
IPSFSLKSCQVLHLNYSR*ILTLER**QPPYLT
EKFKKSSPFEY*YEMGDSLHCPAPQQSSALLKM
KTITHQSLLFPVMTLRFWKTRNQRLSIRF*PLIW
MLAITELLNIT*LMEILMSALL*MRCQENSQPL
VLWTGSKSAILPLSFCALTWEIHLGAL*YTCKL
EFWMPMTTVLLFPHFITSPL*EKMLKWEQWFLCF
QLWTRMKA*MGKLSIF*LMRLLVHSPLILCQAH
*KPATPSTVKPDLSIHLVLWPETVASRVHEAPL
*L*KYMSLMLMTMIQFWNRTLLMCFFPPSRLQTR
QLSL*ELMTWTWGPMELWFLVLQRPSQCFLLIN
TQEKFNFSKIHLQNTSLSGCS*KLQTRAFQPGQ
PRVSWSFTWKEKM*RFPSATTCIKGS*LKIVRQV
LLL*LLKLLLLTQFRTA*NIQFLVEMKMEFFPC
ALSQDNSL*KNPSFLILKSEMRFNSSF*LKVVG
IEPIAK*QS*YRMRMIIHHALNKAFTRHQCLKAN
STMLMSYRFLLPTWTVV*TA*LSILFCLATKKK
HSRLMH*VV**QQKRF*ITSSPAPTA*LSKPQI
KGCPGFLIRL*SRYR*LI*MTMPQLFSPLKQWKL
QKILCLV*L*LMCQFMMWI*IQLSYSVLPKRVI
LEPSLLLIRTLEWWCW*KHWILKK*LNMSCSSK
FLIQCTTQREHL*SVCWMSMIIHQCFLKISIRSQ
FLNQYLWGIQC*LCQPQT*KAMRTFLTEFYPLL
RNSPLILRMAQYLLSVPYYFWIQYQQLNFLWKP
VMVEILT*ELLL*WR*E*KI*TIMPLNSQSNPII
LA*VRMLWLEARLLHFQTSTMTGPVKTHMLNIP
SSVVIHRTIFMWKLSSFIQNILISKSVILCCFT
VWTEKQVLAMSLSFWHLTVAALH*VPQLSYQYKY
LMSMTIPQTSAA*AITPMSRKAPL*GVTSLWSQ
QMTVTQGHMQKSSTTSSLEMRRDIFT*KKTLEF
FI*LNLWIMKK*QNSP*LSKLQMQKRNIFLLQLC
LSVSWMITTMHLSLCSQASAVLFQKICLFPLPY
AL*MLWILMLVRMEN*PILLYHPVFSLMECLMI
MISSSLTL*QGIFMLSKSLTMKMAINTASQSKPK
TKVMQLPP*WSGWILKG*MNLSPFSLKISIFSP
SQKRIKTDS*LAEWKPQMQMLVLMESFFTPLEP
HLLSFQ*IKPMEIFI*LEPFP**KVNSTKKTPWK
*K*SLIVPNQIPSLHLALFL*MCLSPLKEHPWQ
CSPAAFQSAWWSPF*CF*YSSAF*L**F*DINK
KTQ*TIMRRRKPHL*MRT*E*PGMPVCSKPSRKL
TTAVTRWSLWMPLRNG*V**VSWRRILSICTDT
QTPVATVLWKEKLQKIRKSRG*MSIPTESAQTQ
L*VTTSPGCQTRVSRGTQTSSPAYLGKLM*W*LP
KQQKPAKHLGKEIKGKAAAPPVLKIMCYPRQFR
RERQKRASWLTLEKSLSLFQVIRK*GVQLFQLR
RPLIMMEKTTITGIIFLVGSPNSNLLPQYLMILQ
N*RMNICICLAFQKRRNLLFFHPL**QQ*PSLG
LKQSHQECRQ*TWGRCLRNTHALPSPTILVLCQ
KA*LPIFLHLFPY*RCSLLPCLHC*EKENY*EHT
SVVHAMNLKQKMKFKY

Frame 2

ETG*DNEIRE*RRRKEDVYSAV*KY*CLCI*GV
CENKFHCEISESVWIEKR*SRD*ALGCYSVQKP
GRERKTSEGN*GDSL*CRFRTLWLY*IFSL*WI
PEL*STSGIPDRPS*WANLCFSRYRQGKGSSYL*
SPGGS*GWG*AENDTFSPGEGWAKCPSLCSCGP
GGRE**SSCV*PINLCDEHQ**DPARHRDHQCS
CH*PGLWDIWDSGL*AYSRKRVVPFYH*LHHRTL
*SRGRNSECCQLFSRQGSNEQFRDVFTSAKALQ
EG*KR*GSCRKKI*S*QRLVHEV*GKTPSPLPK
SAR*SSKC*WRSCSKVCSKSS*DSW*RNYLLNIT
S*SFGIYHTFVDGLCSRRWWAHSCH*CRCHHTH
FPDNSGTC*V*KA*VHFLSL*RCA*R*SHWNSE
SKRALELLRTNLLQDFFW*SRRKVLHSPAAGHYS
HPEAPGSRDAARGCAHGAGAARQRPSLQQHRGQ
HNSHGCQ*QPPSVPQDLG*D*NIPDHAPWHSLV
PRTCGRQRQWAERTHPVLHRQPAARRLCHRQSPG
GAVPQRQPGRGRAAGAHADSQGRGPRRASSGSP
AGADSRYRETRTQPILDFRTFGLSSGSQ*VSLT
DDTNAANTGAPTWPPACSLAS*VLAGTQRRLCYV
WNPPLHGLDLFAATV*L*IHPNI*F*SVCLDPR
GRILAKCEHYSHCSCLG*E*QFPHLLA*CVVFE
SRREPCSPRGNRQNYSY*HGLWKEWTAIIFPFV*
WKILQDES*YRSSRHHLCHNLGRWCCCL*WDRL
CIQF**TSSLCSQVSVL*IRRRRVNQLGGTGS*
APGAP*DDCASDRPRLPTTKRHHGGLRLSY*HQ*
*QALLPPVSPWKGVTREGSGRSTSKYVGYNCVC
KGS**RK*CRSYILSIFRR*F*SL*D*RQQW*N
KNNHNTFV*L*TFLQNECHCH*PGSASSSRTGSC
*YSGDPTIQRESNHVSEY*TFNYTRKFEAHKNN
ELDKVI*SPSTTL*WKVTF*YCCR**GWTL*NR
QLNRRLVSF*GT*L*DDISLSFQSDYYRP*QKPF
PE*HSLP*YRCGRSE*PFPIFPG*AHCDQCRGE
CSHRNPGVCLQCQR**RQFFEQ*NTILH*IPQP
WHESISHPPLIWHTSHCVPS*QRKHSNCHPDSNS
I*SGCECDRPATEITDSTNSDFGCK*PQPHFYF
FPQCPCQRGCHSGLLGPPHNCSRSRRRKEWKSN
IQHPLRK*KHDVYAR*VIRLTNHNLSFGL*NENS
AYSDCSGTG*WHTSTFFIPDFDSYCS*CK**SS
SI*AAPV*SLSERKPKSRGVCYQG*SSGQRFRS
QFQASV*NHARCFI*IIRDKF*HWRGSDNHHT*Q
RNSRSLHPSSTSTRWGIPFIVQHHNNPLHC*R*
KRSRTRVYCFQL*H*GSGKPGTRGCLYGFSL*Y
GCWQ*QSC*ISHN*WKY**VLYYK*DVRRTLNHS
CFGPGANQQFYPCHSVL*PGRST*ELCNTPAS*
SFGCQ*PQSFFSHTLLPVLCERRC*SGNSGSCA
FSCGQG*RPEWAN*VFSD**GFWCIHH*SYVRHI
ENQQHPRP*SQISAYI*CCGQRL*HPGFTKHHC
NYKSICH*C**Q*SSFGTEPF*CVSFPRVAYKP
DNCHCES**PGLGAQWNCGF*FCRDPVNVFY**I
HRRNSISAKSIFRILPYLAAVKSYRPGHSSQDN
HGSLGHSHGRRRCKDFLQPPPV*RARD*KL*GR
YFYCDC*SFCS*LNSGQHEIFNF*WK*RWSSFPV
L*VRTTHCERTQVS*F*SQK*GSTHRFS*K*WA
*SLLQSSSLDTG*E**FTML*TKHLPGISV*KP
TLQCSCHTGFCYRLGQWFERPD*VFYSVWQPRRS
IPD*CTEWCDNNKSDSRLRAHQLLQLDCPSHR*
RDAQAF*YDCNQGTGD*YK*QCPSFSPL*SSGN
YRRFFAWCNCDSCVSS*CGFEFSFHIQFCQRE*S
WNQVCY*SEHWSGGVGENIGF*RND*I*AAHPN
F*FSALHRGSTCSPCAGCQ**STSVFSRFLSGH
SS*INTCGVFSADSVSHRLRKQ*EHFLQNSILF*
GILH*S*EWHNIYYQSRITSGYNINNSISCGSQ
*WWKS*PESSYFSGDRNRRYEQLCP*IHSQIL*
S*PK*GCSGWKHACYIFKHRP*LDP*KHIC*IFH
HQW*FTEQFSCGN*VLSFRISL*ASRLSCVASQ
SGQRSKC*P*ACHSGI*QWLPSIEFHSCHINTS
T*CQ*QSPKLQQPELSHPCQGKHPSRESHHCGLS
K*P*HRVTCRNHLQHHLWK*EGTFLLRRKHWSS
LFD*TSGL*KNDKIHLNCPSFRCRKETFFFCSC
VCQCPG**RPCTSVYVLKLQLYCSRKSAYFLYHM
LYKCSGF*CWSVWRIDLFYCITLFSHSWNVL*S
*SLPH*PFDRGYSC*ANP*L*KWQ*ILPHSPSQ
RQR*CNCLLSGLGGY*RDR*I*AHFHSRSVFFHP
PRKE*RQTVDWQSGSLRCRCWY*WSHSLLPWNL
ISFLFSK*NQWKYLFD*SPSPNKKSTQQRRHLG
NENNRS*SQIRFQVCILHCFCECVFLL*RNTLGS
VRQQLFNQPGGLLFSVSDTHLHSNCNDFKT*TK
RHNKQL*GEENLIFRCGLESDPGCQCAQSLPEN
*RLQ*RGGPCGCHSGMVEFNKYHGEGYCQSVQTL
KLQWPLFCGRRNCRR*GNPEDK*ASLQKVLRLS
SE*PRVQGARLGYPEGLRPALLPIWGN*CDGDC
RNSRSQPNIWGRRSRGRLQHHLCSK*CVTPDSSE
ERGKREHPG*R*KRVCLYFR*SGSKVCSSFNSD
DL*S*WKRQLSLELSS*LGAQIPTSCLSI**YC
KTKG*TFAYAWHSKREEIFCFSTPFDNSSSPAWD
*SSPTKNAGSKPGAGASETPTLSHPLPSWFSAR
RHDSQFFSISFPIDDAASCLVSTVERRRIIRNT
HQWYMP*T*SRR*SSNM

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