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Sequences

Sequence NM_144508

AGATTTGAATACTTCACTGAGGCGAGCCGGGCGTTGTGAGCGGACTGCTAGAGGCGGCTGTCTGTTTCCGCTCTAAGGAAACTCAGAGCGTGTGGACCCC AAACAAGTCTGCGCAAAATTTGTCGAGGAGGTTTGCCGCGGCAGAAAAGTTTTCTTCAAAAATGGATGGGGTGTCTTCAGAGGCTAATGAAGAAAATGAC AATATAGAGAGACCTGTTAGAAGACGGCATTCTTCAATATTGAAACCCCCAAGGAGTCCTCTTCAGGACCTCAGAGGTGGGAATGAAAGAGTTCAGGAAT CCAATGCTTTGAGAAATAAGAAAAACTCTCGTCGAGTCAGCTTTGCAGATACTATAAAGGTATTCCAGACGGAGTCTCATATGAAAATAGTGAGAAAGTC AGAAATGGAAGAAACAGAAACAGGAGAAAATCTTCTTTTGATACAGAATAAGAAATTAGAAGATAATTACTGTGAAATTACTGGGATGAACACATTGCTT TCTGCTCCCATTCATACCCAGATGCAACAGAAGGAGTTTTCAATTATAGAACATACCCGTGAAAGGAAACATGCAAATGACCAGACAGTCATTTTTTCAG ATGAAAACCAGATGGACCTGACATCAAGTCACACTGTAATGATTACCAAAGGCCTTTTAGATAATCCCATAAGTGAAAAGTCCACCAAGATAGATACCAC ATCATTTCTAGCTAATTTAAAGCTTCACACCGAGGACTCAAGAATGAAAAAAGAAGTAAATTTTTCCGTGGATCAAAACACTTCTTCAGAAAATAAAATA GATTTCAATGACTTCATAAAAAGATTGAAAACAGGAAAATGTAGTGCTTTTCCTGATGTGCCTGATAAAGAAAATTTTGAGATACCTATTTATTCCAAGG AACCGAACAGTGCCTCTTCTACACATCAAATGCATGTATCTCTTAAGGAAGATGAAAATAACAGTAATATTACTAGGCTCTTTAGAGAAAAAGATGATGG GATGAATTTCACCCAGTGTCATACAGCCAATATTCAGACATTGATTCCCACATCCAGTGAGACCAACTCACGGGAATCTAAAGGTAATGATATTACAATT TATGGCAATGACTTTATGGACTTGACATTTAACCACACTTTGCAGATCTTACCTGCAACAGGTAATTTTTCTGAAATAGAAAATCAAACTCAGAATGCCA TGGATGTAACAACAGGTTATGGAACTAAAGCTTCAGGAAATAAAACAGTTTTTAAGAGTAAACAAAATACTGCTTTTCAAGACCTTTCCATAAACTCTGC AGACAAAATACATATTACCAGAAGTCATATTATGGGGGCAGAAACTCACATAGTCTCACAGACTTGTAATCAGGATGCCAGAATATTAGCCATGACCCCA GAATCTATATATTCTAATCCATCTATTCAAGGTTGTAAGACTGTTTTCTATTCTAGTTGTAATGATGCCATGGAAATGACCAAATGTCTCTCAAATATGA GAGAGGAGAAAAATTTGCTAAAGCATGACAGTAATTATGCTAAAATGTATTGCAATCCAGATGCTATGTCTTCTCTCACAGAGAAAACTATTTATTCCGG AGAGGAGAACATGGACATTACCAAGAGTCATACAGTTGCAATAGATAATCAAATTTTTAAACAAGATCAATCAAATGTGCAAATAGCAGCTGCACCAACA CCCGAAAAAGAAATGATGCTCCAAAATCTTATGACCACATCAGAAGATGGGAAAATGAATGTAAATTGTAACTCAGTTCCTCATGTATCTAAGGAAAGAA TACAGCAGAGCCTGTCAAATCCTTTGTCTATTTCATTGACTGATAGAAAGACTGAACTCTTATCAGGTGAAAATATGGATTTGACTGAAAGTCACACAAG TAACTTAGGAAGTCAGGTTCCTCTTGCAGCTTATAATCTAGCACCGGAGAGTACCAGTGAATCTCACTCTCAGAGCAAAAGCTCTTCAGATGAATGTGAA GAAATTACCAAAAGTCGTAATGAACCATTTCAGCGATCAGACATAATAGCCAAAAACAGCTTAACCGACACCTGGAACAAAGACAAAGATTGGGTTTTGA AGATTTTGCCCTACCTTGATAAAGATTCTCCTCAGTCAGCTGATTGTAATCAGGAGATAGCAACAAGCCATAATATAGTCTACTGTGGTGGAGTTCTTGA TAAACAAATAACTAATAGAAATACAGTATCATGGGAACAATCTTTGTTTTCTACCACAAAGCCATTATTTTCATCAGGACAGTTCTCTATGAAAAATCAT GATACTGCTATAAGTAGTCATACAGTGAAATCTGTACTAGGCCAGAATTCTAAACTGGCTGAGCCACTGAGGAAAAGTTTAAGCAATCCCACACCTGACT ATTGCCATGACAAGATGATTATATGTTCAGAGGAAGAGCAAAATATGGATCTAACAAAGAGCCACACTGTCGTCATTGGATTTGGTCCTTCTGAACTACA AGAACTTGGTAAAACTAATTTAGAACACACTACTGGCCAGCTAACAACAATGAACAGACAGATAGCTGTAAAAGTTGAAAAATGTGGTAAAAGTCCCATA GAAAAAAGTGGAGTGCTTAAATCTAACTGTATTATGGATGTGTTAGAGGACGAAAGTGTACAGAAACCTAAATTTCCAAAGGAAAAGCAAAATGTCAAAA TTTGGGGAAGGAAAAGTGTTGGTGGACCAAAAATTGATAAGACTATTGTATTTTCAGAAGACGATAAGAATGATATGGATATCACTAAGAGTTATACAAT AGAAATAAACCATAGACCTTTATTAGAGAAACGTGATTGTCATTTGGTGCCATTGGCAGGAACTTCTGAAACTATTTTATATACATGTAGGCAGGATGAC ATGGAGATCACTAGAAGTCACACAACTGCCTTAGAATGTAAAACTGTCTCACCAGATGAAATAACTACTAGGCCTATGGACAAAACTGTAGTGTTTGTAG ATAATCATGTTGAACTAGAAATGACAGAGTCCCATACTGTTTTCATTGACTACCAAGAAAAGGAAAGAACAGACAGACCTAACTTTGAACTATCCCAAAG GAAAAGCCTAGGAACACCAACAGTGATATGTACTCCTACTGAGGAGAGTGTTTTCTTTCCAGGAAATGGTGAAAGTGACCGTCTAGTAGCAAATGACAGC CAGCTAACCCCTCTGGAGGAATGGTCTAATAATAGGGGCCCTGTAGAGGTAGCTGATAACATGGAATTGTCTAAATCAGCCACTTGCAAAAACATCAAAG ATGTACAAAGTCCTGGATTTCTGAATGAACCTCTATCAAGCAAAAGTCAGAGAAGAAAAAGCCTTAAGCTAAAAAATGACAAGACCATTGTATTTTCAGA GAATCATAAAAATGATATGGATATTACCCAGAGTTGTATGGTGGAAATAGATAACGAAAGTGCCCTGGAGGATAAAGAGGACTTCCATTTGGCAGGGGCT TCTAAAACTATTTTGTATTCATGTGGGCAGGATGACATGGAGATCACTAGGAGTCACACAACTGCCTTAGAATGTAAAACTCTCCTGCCAAATGAAATAG CTATTAGGCCCATGGACAAAACCGTATTGTTCACAGATAATTACAGTGATCTGGAAGTCACCGATTCCCATACTGTTTTCATTGACTGTCAAGCCACAGA GAAAATACTTGAAGAAAACCCTAAATTTGGAATAGGAAAAGGAAAAAACTTGGGTGTTTCCTTTCCTAAGGATAATAGCTGTGTTCAAGAAATCGCTGAA AAACAAGCACTGGCTGTAGGAAACAAAATAGTTCTTCACACCGAGCAAAAGCAACAACTCTTTGCTGCTACTAATAGAACTACTAATGAAATCATCAAAT TTCATAGTGCTGCTATGGATGAAAAGGTCATAGGGAAAGTTGTAGACCAGGCCTGTACATTGGAAAAAGCGCAAGTTGAAAGCTGTCAGTTAAATAATAG AGATAGAAGAAATGTGGACTTTACAAGTAGTCATGCAACTGCTGTTTGTGGATCCAGTGATAATTATTCCTGTTTACCAAATGTTATTTCCTGTACTGAT AATTTGGAGGGTAGTGCCATGCTCTTATGTGATAAAGATGAGGAAAAAGCCAATTATTGCCCAGTGCAAAATGATCTTGCTTATGCAAATGATTTTGCCA GTGAATATTACTTGGAATCTGAGGGACAGCCTCTCTCTGCTCCTTGTCCTTTGTTAGAGAAGGAAGAAGTTATTCAAACCAGTACCAAAGGACAGTTAGA CTGTGTTATAACACTGCACAAAGATCAAGATCTGATTAAGGATCCACGAAATCTATTGGCTAATCAAACTTTAGTATATAGTCAAGATCTGGGGGAGATG ACTAAACTTAATTCAAAGCGAGTATCTTTTAAGCTTCCAAAGGATCAAATGAAAGTCTATGTTGATGACATTTATGTTATTCCTCAGCCTCATTTCTCAA CCGACCAACCTCCATTACCTAAAAAAGGACAGAGTAGTATCAATAAAGAAGAAGTAATACTGTCTAAAGCTGGAAATAAGAGTTTAAATATTATAGAAAA TTCCTCTGCACCCATATGTGAAAACAAGCCCAAAATACTCAATAGTGAGGAATGGTTTGCTGCAGCCTGTAAAAAAGAACTGAAGGAAAATATTCAAACA ACTAACTATAATACAGCTCTAGATTTCCACAGTAACTCAGACGTAACTAAGCAAGTCATTCAAACTCATGTCAATGCTGGAGAAGCACCAGATCCTGTAA TTACATCTAATGTTCCATGTTTTCATAGTATCAAACCAAATCTGAATAATTTGAATGGAAAAACTGGAGAGTTTTTAGCCTTTCAAACTGTTCATCTACC ACCCCTTCCAGAGCAATTACTTGAATTAGGAAATAAGGCACACAATGATATGCATATAGTGCAAGCTACAGAAATACATAATATTAACATAATCTCCAGC AATGCTAAAGATAGTAGAGATGAGGAAAATAAAAAGTCTCATAATGGAGCTGAAACCACCTCTCTACCGCCAAAGACAGTTTTTAAAGATAAAGTAAGGA GATGTTCTTTGGGAATCTTTTTGCCTAGATTGCCCAACAAGAGAAATTGTAGTGTCACTGGTATTGATGACCTGGAACAGATTCCAGCAGACACAACTGA TATAAATCACTTAGAAACTCAGCCGGTCTCTAGCAAAGATTCAGGCATTGGATCTGTTGCAGGTAAACTGAACCTAAGTCCTTCTCAATATATAAATGAG GAAAATCTTCCTGTATATCCTGATGAGATCAATTCTTCAGACTCTATTAACATAGAAACTGAGGAAAAGGCCTTGATTGAGACATACCAAAAAGAGATTT CACCATATGAAAATAAAATGGGAAAAACTTGCAATAGCCAAAAAAGAACGTGGGTACAAGAAGAAGAAGATATTCATAAGGAGAAAAAAATCAGAAAAAA TGAGATTAAGTTTAGTGATACGACACAAGATCGGGAGATTTTTGATCACCATACTGAAGAGGATATAGATAAAAGTGCTAACAGTGTATTGATAAAAAAC CTGAGCAGGACCCCATCTAGTTGCAGCAGCTCTCTGGATTCAATCAAGGCTGATGGGACCTCTCTGGACTTCAGCACTTACCGCAGTAGTCAAATGGAAT CACAGTTTCTCAGAGATACTATTTGTGAAGAGAGCTTGAGGGAGAAACTCCAAGATGGGAGAATAACAATAAGGGAGTTCTTTATACTTCTCCAGGTCCA CATCTTGATACAGAAACCCCGACAGAGCAATCTCCCAGGCAATTTTACTGTAAACACACCACCTACTCCAGAAGACCTGATGTTAAGTCAATATGTTTAC CGACCCAAGATACAGATTTATAGAGAAGATTGTGAGGCTCGTCGCCAAAAGATTGAAGAATTAAAGCTTTCTGCATCGAACCAAGATAAGCTGTTGGTTG ATATAAATAAGAACCTGTGGGAAAAAATGAGACACTGCTCTGACAAAGAGCTGAAGGCCTTTGGAATTTATCTTAACAAAATAAAGTCATGTTTTACCAA GATGACTAAAGTCTTCACTCACCAAGGAAAAGTGGCTCTGTATGGCAAGCTGGTGCAGTCAGCTCAGAATGAGAGGGAGAAACTTCAAATAAAGATAGAT GAGATGGATAAAATACTTAAGAAGATCGATAACTGCCTCACTGAGATGGAAACAGAAACTAAGAATTTGGAGGATGAAGAGAAAAACAATCCTGTGGAAG AATGGGATTCTGAAATGAGAGCTGCAGAAAAAGAATTGGAACAGCTGAAAACTGAAGAAGAGGAGCTTCAAAGAAATCTCTTAGAACTGGAGGTACAAAA AGAGCAGACCCTTGCTCAAATAGACTTTATGCAAAAACAAAGAAATAGAACTGAAGAGCTACTGGATCAGTTGAGCTTGTCTGAGTGGGATGTCGTTGAG TGGAGTGATGATCAAGCTGTATTCACCTTTGTTTATGACACGATACAACTCACCATCACCTTTGAAGAGTCAGTTGTTGGTTTCCCTTTCCTGGACAAGC GTTATAGGAAGATTGTTGATGTCAATTTTCAATCTCTGTTAGATGAGGATCAAGCTCCTCCTTCCTCCCTTTTAGTTCATAAGCTTATTTTCCAGTACGT TGAAGAAAAGGAATCCTGGAAGAAGACATGTACAACCCAGCATCAGTTACCCAAGATGCTTGAAGAATTCTCACTGGTAGTGCACCATTGCAGACTCCTT GGAGAGGAGATTGAGTATTTAAAGAGATGGGGACCAAATTATAACCTAATGAACATAGATATTAATAATAATGAATTGAGACTTTTATTCTCTAGCTCCG CAGCATTTGCAAAGTTTGAAATAACTTTGTTTCTCTCAGCCTATTATCCATCTGTACCATTACCTTCCACCATTCAGAATCACGTTGGGAACACTAGCCA AGATGATATTGCTACCATTCTATCTAAAGTGCCACTGGAGAACAACTACCTGAAGAATGTAGTCAAGCAAATTTACCAAGATCTGTTTCAGGACTGCCAT TTCTACCACTAGACCCTTGGACCACCATTGGAACAACCAAGCAGAATGTACTTGATATTATTTCAGGGTCCCATTGCTGTTCAGCCTTTGTTTTTACGTC ATTACAAGCTGAGTAAAATTCCTTCTGATGATGTTATAGTTAATCTGTATGTTTTTTATATCTCTGCAGAATGATGGTGATGAAGTCTGGATGGTAGGCC TCATAGCCTACTATCAACTTACTCATCTTTGTACCAAAGGTTTAAGTAATAGGACACTTAGGAAAAATGTCTCCTAACTAAACTAGTGCTTTCTGCTTTA GTACAAGCCCTAAGGATTAACTTAAGTATAAGAAGTGTTATCACTGACAAGAACATTAGCCATTTTCCCATAACTAGATAGAGCTATGATTTTTTAGGTT GCCTGGCTTCTGCCTAGCAGATATTTCTGGAGTAGAAATGTATCTGTCTACAAACTATTATCCTTTTTCTCCGTTACTAAAATGCTATTAAGAGAAAGTA GGGCTGGGTGTGAGCCACCACACCCAGCAATGTTTTCTTAATAAGTATAGTTTTTCTAGGGAAAGTTAATTCATTTTTGTCTAGTACATATATGTAAATA TATTAATGTTGTTTTTGTGTTTGTGATGTAGTAAGGAGATGTACATAGAAATTCATTGAGGTATATAGATACTCATCTGTCTAGGCAGTTCCCAATTTTC TGAAGAATGTTTTACAGCAAAATTTTCTATTTTCTTTTATTAAATAGTGACACGTCAAACAATGTCACATCCAAAACACTAGTTTCATCAATTTCTAGCA GTAATAATAGACTTGCTGTAAGTATTGTTTTCTGATGCCATACCCTTGTCATACATATTATTAAATGACCAATATTATGTATGAAGTAGACAAAAAAATT TACTCAAACTTCATTCAAATCCTAATTGTGATAATTTTTGTTTTATATTTAATTATAAACCAAAATACATTTGCATTTTTAAGCTAATTTGTCTCAAAAT TTTGCTTTATATTTTTGGATCAGGTTAAAGTCCTGTGGATCCCCTGAATGTTATTGTCCCTCTTGATTGGTTTTTACTTCTGAGCTATACGTCAAAAGAC ACATAAGCTTCAAAAGTCAAGACAAACCTCATTTGCCATAAAAATCAAGATATAGATGTTCTGTTCCGTAAACTCCTTGAAAAACATTTTAAAGTCATCA ATATGATCTGTTTCCCATGAAACTTAAGTTAGCTTTCTTATTGGAGTTATTTCTTTTCTGTAAGTCTGAAAAGTAGAGATTTTGTTTTACGCATTTTAGT AACCTGCAACAACCAACTCTAAAAAAGATTTGGCTTGTAATGACGGTCTCTGCTTTTTTGGGTTTGGAGTACACAATTGTAATATTTACTTAGTTATTTG TGTTTTTCTTTGTTCAAGGTATTGACTAGTTTCATAAATTTTTTGAAAGTTTTTCTTTCATTGGTTGGAAAGCAGATTACATTTTGCACTATTAAAATAA GTTTATTACTTTAAA

refseq_CASC5.F1 (forward primer)
refseq_CASC5.R1 (reverse primer)
Single exon skipping

Frame 0

RFEYFTEASRAL*ADC*RRLSVSALRKLRACGP QTSLRKICRGGLPRQKSFLQKWMGCLQRLMKKMT I*RDLLEDGILQY*NPQGVLFRTSEVGMKEFRN PML*EIRKTLVESALQIL*RYSRRSLI*K**ES QKWKKQKQEKIFF*YRIRN*KIITVKLLG*THCF LLPFIPRCNRRSFQL*NIPVKGNMQMTRQSFFQ MKTRWT*HQVTL**LPKAF*IIP*VKSPPR*IP HHF*LI*SFTPRTQE*KKK*IFPWIKTLLQKIK* ISMTS*KD*KQENVVLFLMCLIKKILRYLFIPR NRTVPLLHIKCMYLLRKMKITVILLGSLEKKMM G*ISPSVIQPIFRH*FPHPVRPTHGNLKVMILQF MAMTLWT*HLTTLCRSYLQQVIFLK*KIKLRMP WM*QQVMELKLQEIKQFLRVNKILLFKTFP*TL QTKYILPEVILWGQKLT*SHRLVIRMPEY*P*PQ NLYILIHLFKVVRLFSILVVMMPWK*PNVSQI* ERRKIC*SMTVIMLKCIAIQMLCLLSQRKLFIP ERRTWTLPRVIQLQ*IIKFLNKINQMCK*QLHQH PKKK*CSKIL*PHQKMGK*M*IVTQFLMYLRKE YSRACQILCLFH*LIERLNSYQVKIWI*LKVTQ VT*EVRFLLQLII*HRRVPVNLTLRAKALQMNVK KLPKVVMNHFSDQT**PKTA*PTPGTKTKIGF* RFCPTLIKILLSQLIVIRR*QQAII*STVVEFL INK*LIEIQYHGNNLCFLPQSHYFHQDSSL*KIM ILL*VVIQ*NLY*ARILNWLSH*GKV*AIPHLT IAMTR*LYVQRKSKIWI*QRATLSSLDLVLLNY KNLVKLI*NTLLAS*QQ*TDR*L*KLKNVVKVP* KKVECLNLTVLWMC*RTKVYRNLNFQRKSKMSK FGEGKVLVDQKLIRLLYFQKTIRMIWISLRVIQ *K*TIDLY*RNVIVIWCHWQELLKLFYIHVGRMT WRSLEVTQLP*NVKLSHQMK*LLGLWTKL*CL* IIMLN*K*QSPILFSLTTKKRKEQTDLTLNYPK GKA*EHQQ*YVLLLRRVFSFQEMVKVTV**QMTA S*PLWRNGLIIGAL*R*LITWNCLNQPLAKTSK MYKVLDF*MNLYQAKVREEKALS*KMTRPLYFQ RIIKMIWILPRVVWWK*ITKVPWRIKRTSIWQGL LKLFCIHVGRMTWRSLGVTQLP*NVKLSCQMK* LLGPWTKPYCSQIITVIWKSPIPILFSLTVKPQ RKYLKKTLNLE*EKEKTWVFPFLRIIAVFKKSLK NKHWL*ETK*FFTPSKSNNSLLLLIELLMKSSN FIVLLWMKRS*GKL*TRPVHWKKRKLKAVS*II EIEEMWTLQVVMQLLFVDPVIIIPVYQMLFPVLI IWRVVPCSYVIKMRKKPIIAQCKMILLMQMILP VNITWNLRDSLSLLLVLC*RRKKLFKPVPKDS* TVL*HCTKIKI*LRIHEIYWLIKL*YIVKIWGR* LNLIQSEYLLSFQRIK*KSMLMTFMLFLSLISQ PTNLHYLKKDRVVSIKKK*YCLKLEIRV*IL*K IPLHPYVKTSPKYSIVRNGLLQPVKKN*RKIFKQ LTIIQL*ISTVTQT*LSKSFKLMSMLEKHQIL* LHLMFHVFIVSNQI*II*MEKLESF*PFKLFIY HPFQSNYLN*EIRHTMICI*CKLQKYIILT*SPA MLKIVEMRKIKSLIMELKPPLYRQRQFLKIK*G DVLWESFCLDCPTREIVVSLVLMTWNRFQQTQL I*IT*KLSRSLAKIQALDLLQVN*T*VLLNI*MR KIFLYILMRSILQTLLT*KLRKRP*LRHTKKRF HHMKIKWEKLAIAKKERGYKKKKIFIRRKKSEK MRLSLVIRHKIGRFLITILKRI*IKVLTVY**KT *AGPHLVAAALWIQSRLMGPLWTSALTAVVKWN HSFSEILFVKRA*GRNSKMGE*Q*GSSLYFSRS TS*YRNPDRAISQAILL*THHLLQKT*C*VNMFT DPRYRFIEKIVRLVAKRLKN*SFLHRTKISCWL I*IRTCGKK*DTALTKS*RPLEFILTK*SHVLP R*LKSSLTKEKWLCMASWCSQLRMRGRNFK*R*M RWIKYLRRSITASLRWKQKLRIWRMKRKTILWK NGILK*ELQKKNWNS*KLKKRSFKEIS*NWRYK KSRPLLK*TLCKNKEIELKSYWIS*ACLSGMSLS GVMIKLYSPLFMTRYNSPSPLKSQLLVSLSWTS VIGRLLMSIFNLC*MRIKLLLPPF*FISLFSST LKKRNPGRRHVQPSISYPRCLKNSHW*CTIADSL ERRLSI*RDGDQIIT**T*ILIIMN*DFYSLAP QHLQSLK*LCFSQPIIHLYHYLPPFRITLGTLA KMILLPFYLKCHWRTTT*RM*SSKFTKICFRTAI STTRPLDHHWNNQAECT*YYFRVPLLFSLCFYV ITS*VKFLLMML*LICMFFISLQNDGDEVWMVG LIAYYQLTHLCTKGLSNRTLRKNVS*LN*CFLL* YKP*GLT*V*EVLSLTRTLAIFP*LDRAMIF*V AWLLPSRYFWSRNVSVYKLLSFFSVTKMLLRES RAGCEPPHPAMFS**V*FF*GKLIHFCLVHICKY INVVFVFVM**GDVHRNSLRYIDTHLSRQFPIF *RMFYSKIFYFLLLNSDTSNNVTSKTLVSSISS SNNRLAVSIVF*CHTLVIHIIK*PILCMK*TKKF TQTSFKS*L**FLFYI*L*TKIHLHF*ANLSQN FALYFWIRLKSCGSPECYCPS*LVFTSELYVKR HISFKSQDKPHLP*KSRYRCSVP*TP*KTF*SHQ YDLFPMKLKLAFLLELFLFCKSEK*RFCFTHFS NLQQPTLKKIWLVMTVSAFLGLEYTIVIFT*LF VFFFVQGID*FHKFFESFSFIGWKADYILHY*NK FITL

Frame 1

DLNTSLRRAGRCERTARGGCLFPL*GNSERVDP KQVCAKFVEEVCRGRKVFFKNGWGVFRG**RK* QYRETC*KTAFFNIETPKESSSGPQRWE*KSSGI QCFEK*EKLSSSQLCRYYKGIPDGVSYENSEKV RNGRNRNRRKSSFDTE*EIRR*LL*NYWDEHIA FCSHSYPDATEGVFNYRTYP*KETCK*PDSHFFR *KPDGPDIKSHCNDYQRPFR*SHK*KVHQDRYH IISS*FKASHRGLKNEKRSKFFRGSKHFFRK*N RFQ*LHKKIENRKM*CFS*CA**RKF*DTYLFQG TEQCLFYTSNACIS*GR*K*Q*YY*AL*RKR*W DEFHPVSYSQYSDIDSHIQ*DQLTGI*R**YYN LWQ*LYGLDI*PHFADLTCNR*FF*NRKSNSECH GCNNRLWN*SFRK*NSF*E*TKYCFSRPFHKLC RQNTYYQKSYYGGRNSHSLTDL*SGCQNISHDP RIYIF*SIYSRL*DCFLF*L**CHGNDQMSLKYE RGEKFAKA*Q*LC*NVLQSRCYVFSHRENYLFR RGEHGHYQESYSCNR*SNF*TRSIKCANSSCTN TRKRNDAPKSYDHIRRWENECKL*LSSSCI*GKN TAEPVKSFVYFID**KD*TLIR*KYGFD*KSHK *LRKSGSSCSL*SSTGEYQ*ISLSEQKLFR*M* RNYQKS**TISAIRHNSQKQLNRHLEQRQRLGFE DFALP**RFSSVS*L*SGDSNKP*YSLLWWSS* *TNN**KYSIMGTIFVFYHKAIIFIRTVLYEKS *YCYK*SYSEICTRPEF*TG*ATEEKFKQSHT*L LP*QDDYMFRGRAKYGSNKEPHCRHWIWSF*TT RTW*N*FRTHYWPANNNEQTDSCKS*KMW*KSH RKKWSA*I*LYYGCVRGRKCTET*ISKGKAKCQN LGKEKCWWTKN**DYCIFRRR*E*YGYH*ELYN RNKP*TFIRET*LSFGAIGRNF*NYFIYM*AG* HGDH*KSHNCLRM*NCLTR*NNY*AYGQNCSVCR *SC*TRNDRVPYCFH*LPRKGKNRQT*L*TIPK EKPRNTNSDMYSY*GECFLSRKW*K*PSSSK*Q PANPSGGMV***GPCRGS**HGIV*ISHLQKHQR CTKSWISE*TSIKQKSEKKKP*AKK*QDHCIFR ES*K*YGYYPELYGGNR*RKCPGG*RGLPFGRG F*NYFVFMWAG*HGDH*ESHNCLRM*NSPAK*NS Y*AHGQNRIVHR*LQ*SGSHRFPYCFH*LSSHR ENT*RKP*IWNRKRKKLGCFLS*G**LCSRNR* KTSTGCRKQNSSSHRAKATTLCCY**NY**NHQI S*CCYG*KGHRESCRPGLYIGKSAS*KLSVK** R*KKCGLYK*SCNCCLWIQ**LFLFTKCYFLY* *FGG*CHALM**R*GKSQLLPSAK*SCLCK*FCQ *ILLGI*GTASLCSLSFVREGRSYSNQYQRTVR LCYNTAQRSRSD*GSTKSIG*SNFSI*SRSGGD D*T*FKASIF*ASKGSNESLC**HLCYSSASFLN RPTSIT*KRTE*YQ*RRSNTV*SWK*EFKYYRK FLCTHM*KQAQNTQ**GMVCCSL*KRTEGKYSN N*L*YSSRFPQ*LRRN*ASHSNSCQCWRSTRSCN YI*CSMFS*YQTKSE*FEWKNWRVFSLSNCSST TPSRAIT*IRK*GTQ*YAYSASYRNT*Y*HNLQ QC*R**R*GK*KVS*WS*NHLSTAKDSF*R*SKE MFFGNLFA*IAQQEKL*CHWY**PGTDSSRHN* YKSLRNSAGL*QRFRHWICCR*TEPKSFSIYK* GKSSCIS**DQFFRLY*HRN*GKGLD*DIPKRDF TI*K*NGKNLQ*PKKNVGTRRRRYS*GEKNQKK *D*V**YDTRSGDF*SPY*RGYR*KC*QCIDKK PEQDPI*LQQLSGFNQG*WDLSGLQHLPQ*SNGI TVSQRYYL*RELEGETPRWENNNKGVLYTSPGP HLDTETPTEQSPRQFYCKHTTYSRRPDVKSICL PTQDTDL*RRL*GSSPKD*RIKAFCIEPR*AVG* YK*EPVGKNETLL*QRAEGLWNLS*QNKVMFYQ DD*SLHSPRKSGSVWQAGAVSSE*EGETSNKDR *DG*NT*EDR*LPH*DGNRN*EFGG*REKQSCGR MGF*NESCRKRIGTAEN*RRGASKKSLRTGGTK RADPCSNRLYAKTKK*N*RATGSVELV*VGCR* VE**SSCIHLCL*HDTTHHHL*RVSCWFPFPGQA L*EDC*CQFSISVR*GSSSSFLPFSS*AYFPVR *RKGILEEDMYNPASVTQDA*RILTGSAPLQTP WRGD*VFKEMGTKL*PNEHRY****IETFIL*LR SICKV*NNFVSLSLLSICTITFHHSESRWEH*P R*YCYHSI*SATGEQLPEECSQANLPRSVSGLP FLPLDPWTTIGTTKQNVLDIISGSHCCSAFVFTS LQAE*NSF**CYS*SVCFLYLCRMMVMKSGW*A S*PTINLLIFVPKV*VIGHLGKMSPN*TSAFCF STSPKD*LKYKKCYH*QEH*PFSHN*IEL*FFRL PGFCLADISGVEMYLSTNYYPFSPLLKCY*EKV GLGVSHHTQQCFLNKYSFSRES*FIFV*YIYVN ILMLFLCL*CSKEMYIEIH*GI*ILICLGSSQFS EECFTAKFSIFFY*IVTRQTMSHPKH*FHQFLA VIIDLL*VLFSDAIPLSYILLNDQYYV*SRQKN LLKLHSNPNCDNFCFIFNYKPKYICIFKLICLKI LLYIFGSG*SPVDPLNVIVPLDWFLLLSYTSKD T*ASKVKTNLICHKNQDIDVLFRKLLEKHFKVI NMICFP*NLS*LSYWSYFFSVSLKSRDFVLRILV TCNNQL*KRFGL**RSLLFWVWSTQL*YLLSYL CFSLFKVLTSFINFLKVFLSLVGKQITFCTIKI SLLL*

Frame 2

I*ILH*GEPGVVSGLLEAAVCFRSKETQSVWTP NKSAQNLSRRFAAAEKFSSKMDGVSSEANEEND NIERPVRRRHSSILKPPRSPLQDLRGGNERVQE SNALRNKKNSRRVSFADTIKVFQTESHMKIVRKS EMEETETGENLLLIQNKKLEDNYCEITGMNTLL SAPIHTQMQQKEFSIIEHTRERKHANDQTVIFS DENQMDLTSSHTVMITKGLLDNPISEKSTKIDTT SFLANLKLHTEDSRMKKEVNFSVDQNTSSENKI DFNDFIKRLKTGKCSAFPDVPDKENFEIPIYSK EPNSASSTHQMHVSLKEDENNSNITRLFREKDDG MNFTQCHTANIQTLIPTSSETNSRESKGNDITI YGNDFMDLTFNHTLQILPATGNFSEIENQTQNA MDVTTGYGTKASGNKTVFKSKQNTAFQDLSINSA DKIHITRSHIMGAETHIVSQTCNQDARILAMTP ESIYSNPSIQGCKTVFYSSCNDAMEMTKCLSNM REEKNLLKHDSNYAKMYCNPDAMSSLTEKTIYSG EENMDITKSHTVAIDNQIFKQDQSNVQIAAAPT PEKEMMLQNLMTTSEDGKMNVNCNSVPHVSKER IQQSLSNPLSISLTDRKTELLSGENMDLTESHTS NLGSQVPLAAYNLAPESTSESHSQSKSSSDECE EITKSRNEPFQRSDIIAKNSLTDTWNKDKDWVL KILPYLDKDSPQSADCNQEIATSHNIVYCGGVLD KQITNRNTVSWEQSLFSTTKPLFSSGQFSMKNH DTAISSHTVKSVLGQNSKLAEPLRKSLSNPTPD YCHDKMIICSEEEQNMDLTKSHTVVIGFGPSELQ ELGKTNLEHTTGQLTTMNRQIAVKVEKCGKSPI EKSGVLKSNCIMDVLEDESVQKPKFPKEKQNVK IWGRKSVGGPKIDKTIVFSEDDKNDMDITKSYTI EINHRPLLEKRDCHLVPLAGTSETILYTCRQDD MEITRSHTTALECKTVSPDEITTRPMDKTVVFV DNHVELEMTESHTVFIDYQEKERTDRPNFELSQR KSLGTPTVICTPTEESVFFPGNGESDRLVANDS QLTPLEEWSNNRGPVEVADNMELSKSATCKNIK DVQSPGFLNEPLSSKSQRRKSLKLKNDKTIVFSE NHKNDMDITQSCMVEIDNESALEDKEDFHLAGA SKTILYSCGQDDMEITRSHTTALECKTLLPNEI AIRPMDKTVLFTDNYSDLEVTDSHTVFIDCQATE KILEENPKFGIGKGKNLGVSFPKDNSCVQEIAE KQALAVGNKIVLHTEQKQQLFAATNRTTNEIIK FHSAAMDEKVIGKVVDQACTLEKAQVESCQLNNR DRRNVDFTSSHATAVCGSSDNYSCLPNVISCTD NLEGSAMLLCDKDEEKANYCPVQNDLAYANDFA SEYYLESEGQPLSAPCPLLEKEEVIQTSTKGQLD CVITLHKDQDLIKDPRNLLANQTLVYSQDLGEM TKLNSKRVSFKLPKDQMKVYVDDIYVIPQPHFS TDQPPLPKKGQSSINKEEVILSKAGNKSLNIIEN SSAPICENKPKILNSEEWFAAACKKELKENIQT TNYNTALDFHSNSDVTKQVIQTHVNAGEAPDPV ITSNVPCFHSIKPNLNNLNGKTGEFLAFQTVHLP PLPEQLLELGNKAHNDMHIVQATEIHNINIISS NAKDSRDEENKKSHNGAETTSLPPKTVFKDKVR RCSLGIFLPRLPNKRNCSVTGIDDLEQIPADTTD INHLETQPVSSKDSGIGSVAGKLNLSPSQYINE ENLPVYPDEINSSDSINIETEEKALIETYQKEI SPYENKMGKTCNSQKRTWVQEEEDIHKEKKIRKN EIKFSDTTQDREIFDHHTEEDIDKSANSVLIKN LSRTPSSCSSSLDSIKADGTSLDFSTYRSSQME SQFLRDTICEESLREKLQDGRITIREFFILLQVH ILIQKPRQSNLPGNFTVNTPPTPEDLMLSQYVY RPKIQIYREDCEARRQKIEELKLSASNQDKLLV DINKNLWEKMRHCSDKELKAFGIYLNKIKSCFTK MTKVFTHQGKVALYGKLVQSAQNEREKLQIKID EMDKILKKIDNCLTEMETETKNLEDEEKNNPVE EWDSEMRAAEKELEQLKTEEEELQRNLLELEVQK EQTLAQIDFMQKQRNRTEELLDQLSLSEWDVVE WSDDQAVFTFVYDTIQLTITFEESVVGFPFLDK RYRKIVDVNFQSLLDEDQAPPSSLLVHKLIFQYV EEKESWKKTCTTQHQLPKMLEEFSLVVHHCRLL GEEIEYLKRWGPNYNLMNIDINNNELRLLFSSS AAFAKFEITLFLSAYYPSVPLPSTIQNHVGNTSQ DDIATILSKVPLENNYLKNVVKQIYQDLFQDCH FYH*TLGPPLEQPSRMYLILFQGPIAVQPLFLR HYKLSKIPSDDVIVNLYVFYISAE*W**SLDGRP HSLLSTYSSLYQRFK**DT*EKCLLTKLVLSAL VQALRINLSIRSVITDKNISHFPITR*SYDFLG CLASA*QIFLE*KCICLQTIILFLRY*NAIKRK* GWV*ATTPSNVFLISIVFLGKVNSFLSSTYM*I Y*CCFCVCDVVRRCT*KFIEVYRYSSV*AVPNF LKNVLQQNFLFSFIK**HVKQCHIQNTSFINF*Q ***TCCKYCFLMPYPCHTYY*MTNIMYEVDKKI YSNFIQILIVIIFVLYLIINQNTFAFLS*FVSK FCFIFLDQVKVLWIP*MLLSLLIGFYF*AIRQKT HKLQKSRQTSFAIKIKI*MFCSVNSLKNILKSS I*SVSHET*VSFLIGVISFL*V*KVEILFYAF* *PATTNSKKDLACNDGLCFFGFGVHNCNIYLVIC VFLCSRY*LVS*IF*KFFFHWLESRLHFALLK* VYYFK

Sequence NM_170589

AGATTTGAATACTTCACTGAGGCGAGCCGGGCGTTGTGAGCGGACTGCTAGAGGCGGCTGTCTGTTTCCGCTCTAAGGAAACTCAGAGCGTGTGGACCCC AAACAAGTCTGCGCAAAATTTGTCGAGGAGGTTTGCCGCGGCAGAAAAGTTTTCTTCAAAAATGGATGGGGTGTCTTCAGAGGCTAATGAAGAAAATGAC AATATAGAGAGACCTGTTAGAAGACGGCATTCTTCAATATTGAAACCCCCAAGGAGTCCTCTTCAGGACCTCAGAGGTGGGAATGAAAGAGTTCAGGAAT CCAATGCTTTGAGAAATAAGAAAAACTCTCGTCGAGTCAGCTTTGCAGATACTATAAAGGTATTCCAGACGGAGTCTCATATGAAAATAGTGAGAAAGTC AGAAATGGAAGGCTGCAGTGCAATGGTGCCATCTCAGCTGCAACTTCTGCCTCCTGGGTTTAAGCGATTCTCCTGCCTCAGCCTCCCAGAAACAGAAACA GGAGAAAATCTTCTTTTGATACAGAATAAGAAATTAGAAGATAATTACTGTGAAATTACTGGGATGAACACATTGCTTTCTGCTCCCATTCATACCCAGA TGCAACAGAAGGAGTTTTCAATTATAGAACATACCCGTGAAAGGAAACATGCAAATGACCAGACAGTCATTTTTTCAGATGAAAACCAGATGGACCTGAC ATCAAGTCACACTGTAATGATTACCAAAGGCCTTTTAGATAATCCCATAAGTGAAAAGTCCACCAAGATAGATACCACATCATTTCTAGCTAATTTAAAG CTTCACACCGAGGACTCAAGAATGAAAAAAGAAGTAAATTTTTCCGTGGATCAAAACACTTCTTCAGAAAATAAAATAGATTTCAATGACTTCATAAAAA GATTGAAAACAGGAAAATGTAGTGCTTTTCCTGATGTGCCTGATAAAGAAAATTTTGAGATACCTATTTATTCCAAGGAACCGAACAGTGCCTCTTCTAC ACATCAAATGCATGTATCTCTTAAGGAAGATGAAAATAACAGTAATATTACTAGGCTCTTTAGAGAAAAAGATGATGGGATGAATTTCACCCAGTGTCAT ACAGCCAATATTCAGACATTGATTCCCACATCCAGTGAGACCAACTCACGGGAATCTAAAGGTAATGATATTACAATTTATGGCAATGACTTTATGGACT TGACATTTAACCACACTTTGCAGATCTTACCTGCAACAGGTAATTTTTCTGAAATAGAAAATCAAACTCAGAATGCCATGGATGTAACAACAGGTTATGG AACTAAAGCTTCAGGAAATAAAACAGTTTTTAAGAGTAAACAAAATACTGCTTTTCAAGACCTTTCCATAAACTCTGCAGACAAAATACATATTACCAGA AGTCATATTATGGGGGCAGAAACTCACATAGTCTCACAGACTTGTAATCAGGATGCCAGAATATTAGCCATGACCCCAGAATCTATATATTCTAATCCAT CTATTCAAGGTTGTAAGACTGTTTTCTATTCTAGTTGTAATGATGCCATGGAAATGACCAAATGTCTCTCAAATATGAGAGAGGAGAAAAATTTGCTAAA GCATGACAGTAATTATGCTAAAATGTATTGCAATCCAGATGCTATGTCTTCTCTCACAGAGAAAACTATTTATTCCGGAGAGGAGAACATGGACATTACC AAGAGTCATACAGTTGCAATAGATAATCAAATTTTTAAACAAGATCAATCAAATGTGCAAATAGCAGCTGCACCAACACCCGAAAAAGAAATGATGCTCC AAAATCTTATGACCACATCAGAAGATGGGAAAATGAATGTAAATTGTAACTCAGTTCCTCATGTATCTAAGGAAAGAATACAGCAGAGCCTGTCAAATCC TTTGTCTATTTCATTGACTGATAGAAAGACTGAACTCTTATCAGGTGAAAATATGGATTTGACTGAAAGTCACACAAGTAACTTAGGAAGTCAGGTTCCT CTTGCAGCTTATAATCTAGCACCGGAGAGTACCAGTGAATCTCACTCTCAGAGCAAAAGCTCTTCAGATGAATGTGAAGAAATTACCAAAAGTCGTAATG AACCATTTCAGCGATCAGACATAATAGCCAAAAACAGCTTAACCGACACCTGGAACAAAGACAAAGATTGGGTTTTGAAGATTTTGCCCTACCTTGATAA AGATTCTCCTCAGTCAGCTGATTGTAATCAGGAGATAGCAACAAGCCATAATATAGTCTACTGTGGTGGAGTTCTTGATAAACAAATAACTAATAGAAAT ACAGTATCATGGGAACAATCTTTGTTTTCTACCACAAAGCCATTATTTTCATCAGGACAGTTCTCTATGAAAAATCATGATACTGCTATAAGTAGTCATA CAGTGAAATCTGTACTAGGCCAGAATTCTAAACTGGCTGAGCCACTGAGGAAAAGTTTAAGCAATCCCACACCTGACTATTGCCATGACAAGATGATTAT ATGTTCAGAGGAAGAGCAAAATATGGATCTAACAAAGAGCCACACTGTCGTCATTGGATTTGGTCCTTCTGAACTACAAGAACTTGGTAAAACTAATTTA GAACACACTACTGGCCAGCTAACAACAATGAACAGACAGATAGCTGTAAAAGTTGAAAAATGTGGTAAAAGTCCCATAGAAAAAAGTGGAGTGCTTAAAT CTAACTGTATTATGGATGTGTTAGAGGACGAAAGTGTACAGAAACCTAAATTTCCAAAGGAAAAGCAAAATGTCAAAATTTGGGGAAGGAAAAGTGTTGG TGGACCAAAAATTGATAAGACTATTGTATTTTCAGAAGACGATAAGAATGATATGGATATCACTAAGAGTTATACAATAGAAATAAACCATAGACCTTTA TTAGAGAAACGTGATTGTCATTTGGTGCCATTGGCAGGAACTTCTGAAACTATTTTATATACATGTAGGCAGGATGACATGGAGATCACTAGAAGTCACA CAACTGCCTTAGAATGTAAAACTGTCTCACCAGATGAAATAACTACTAGGCCTATGGACAAAACTGTAGTGTTTGTAGATAATCATGTTGAACTAGAAAT GACAGAGTCCCATACTGTTTTCATTGACTACCAAGAAAAGGAAAGAACAGACAGACCTAACTTTGAACTATCCCAAAGGAAAAGCCTAGGAACACCAACA GTGATATGTACTCCTACTGAGGAGAGTGTTTTCTTTCCAGGAAATGGTGAAAGTGACCGTCTAGTAGCAAATGACAGCCAGCTAACCCCTCTGGAGGAAT GGTCTAATAATAGGGGCCCTGTAGAGGTAGCTGATAACATGGAATTGTCTAAATCAGCCACTTGCAAAAACATCAAAGATGTACAAAGTCCTGGATTTCT GAATGAACCTCTATCAAGCAAAAGTCAGAGAAGAAAAAGCCTTAAGCTAAAAAATGACAAGACCATTGTATTTTCAGAGAATCATAAAAATGATATGGAT ATTACCCAGAGTTGTATGGTGGAAATAGATAACGAAAGTGCCCTGGAGGATAAAGAGGACTTCCATTTGGCAGGGGCTTCTAAAACTATTTTGTATTCAT GTGGGCAGGATGACATGGAGATCACTAGGAGTCACACAACTGCCTTAGAATGTAAAACTCTCCTGCCAAATGAAATAGCTATTAGGCCCATGGACAAAAC CGTATTGTTCACAGATAATTACAGTGATCTGGAAGTCACCGATTCCCATACTGTTTTCATTGACTGTCAAGCCACAGAGAAAATACTTGAAGAAAACCCT AAATTTGGAATAGGAAAAGGAAAAAACTTGGGTGTTTCCTTTCCTAAGGATAATAGCTGTGTTCAAGAAATCGCTGAAAAACAAGCACTGGCTGTAGGAA ACAAAATAGTTCTTCACACCGAGCAAAAGCAACAACTCTTTGCTGCTACTAATAGAACTACTAATGAAATCATCAAATTTCATAGTGCTGCTATGGATGA AAAGGTCATAGGGAAAGTTGTAGACCAGGCCTGTACATTGGAAAAAGCGCAAGTTGAAAGCTGTCAGTTAAATAATAGAGATAGAAGAAATGTGGACTTT ACAAGTAGTCATGCAACTGCTGTTTGTGGATCCAGTGATAATTATTCCTGTTTACCAAATGTTATTTCCTGTACTGATAATTTGGAGGGTAGTGCCATGC TCTTATGTGATAAAGATGAGGAAAAAGCCAATTATTGCCCAGTGCAAAATGATCTTGCTTATGCAAATGATTTTGCCAGTGAATATTACTTGGAATCTGA GGGACAGCCTCTCTCTGCTCCTTGTCCTTTGTTAGAGAAGGAAGAAGTTATTCAAACCAGTACCAAAGGACAGTTAGACTGTGTTATAACACTGCACAAA GATCAAGATCTGATTAAGGATCCACGAAATCTATTGGCTAATCAAACTTTAGTATATAGTCAAGATCTGGGGGAGATGACTAAACTTAATTCAAAGCGAG TATCTTTTAAGCTTCCAAAGGATCAAATGAAAGTCTATGTTGATGACATTTATGTTATTCCTCAGCCTCATTTCTCAACCGACCAACCTCCATTACCTAA AAAAGGACAGAGTAGTATCAATAAAGAAGAAGTAATACTGTCTAAAGCTGGAAATAAGAGTTTAAATATTATAGAAAATTCCTCTGCACCCATATGTGAA AACAAGCCCAAAATACTCAATAGTGAGGAATGGTTTGCTGCAGCCTGTAAAAAAGAACTGAAGGAAAATATTCAAACAACTAACTATAATACAGCTCTAG ATTTCCACAGTAACTCAGACGTAACTAAGCAAGTCATTCAAACTCATGTCAATGCTGGAGAAGCACCAGATCCTGTAATTACATCTAATGTTCCATGTTT TCATAGTATCAAACCAAATCTGAATAATTTGAATGGAAAAACTGGAGAGTTTTTAGCCTTTCAAACTGTTCATCTACCACCCCTTCCAGAGCAATTACTT GAATTAGGAAATAAGGCACACAATGATATGCATATAGTGCAAGCTACAGAAATACATAATATTAACATAATCTCCAGCAATGCTAAAGATAGTAGAGATG AGGAAAATAAAAAGTCTCATAATGGAGCTGAAACCACCTCTCTACCGCCAAAGACAGTTTTTAAAGATAAAGTAAGGAGATGTTCTTTGGGAATCTTTTT GCCTAGATTGCCCAACAAGAGAAATTGTAGTGTCACTGGTATTGATGACCTGGAACAGATTCCAGCAGACACAACTGATATAAATCACTTAGAAACTCAG CCGGTCTCTAGCAAAGATTCAGGCATTGGATCTGTTGCAGGTAAACTGAACCTAAGTCCTTCTCAATATATAAATGAGGAAAATCTTCCTGTATATCCTG ATGAGATCAATTCTTCAGACTCTATTAACATAGAAACTGAGGAAAAGGCCTTGATTGAGACATACCAAAAAGAGATTTCACCATATGAAAATAAAATGGG AAAAACTTGCAATAGCCAAAAAAGAACGTGGGTACAAGAAGAAGAAGATATTCATAAGGAGAAAAAAATCAGAAAAAATGAGATTAAGTTTAGTGATACG ACACAAGATCGGGAGATTTTTGATCACCATACTGAAGAGGATATAGATAAAAGTGCTAACAGTGTATTGATAAAAAACCTGAGCAGGACCCCATCTAGTT GCAGCAGCTCTCTGGATTCAATCAAGGCTGATGGGACCTCTCTGGACTTCAGCACTTACCGCAGTAGTCAAATGGAATCACAGTTTCTCAGAGATACTAT TTGTGAAGAGAGCTTGAGGGAGAAACTCCAAGATGGGAGAATAACAATAAGGGAGTTCTTTATACTTCTCCAGGTCCACATCTTGATACAGAAACCCCGA CAGAGCAATCTCCCAGGCAATTTTACTGTAAACACACCACCTACTCCAGAAGACCTGATGTTAAGTCAATATGTTTACCGACCCAAGATACAGATTTATA GAGAAGATTGTGAGGCTCGTCGCCAAAAGATTGAAGAATTAAAGCTTTCTGCATCGAACCAAGATAAGCTGTTGGTTGATATAAATAAGAACCTGTGGGA AAAAATGAGACACTGCTCTGACAAAGAGCTGAAGGCCTTTGGAATTTATCTTAACAAAATAAAGTCATGTTTTACCAAGATGACTAAAGTCTTCACTCAC CAAGGAAAAGTGGCTCTGTATGGCAAGCTGGTGCAGTCAGCTCAGAATGAGAGGGAGAAACTTCAAATAAAGATAGATGAGATGGATAAAATACTTAAGA AGATCGATAACTGCCTCACTGAGATGGAAACAGAAACTAAGAATTTGGAGGATGAAGAGAAAAACAATCCTGTGGAAGAATGGGATTCTGAAATGAGAGC TGCAGAAAAAGAATTGGAACAGCTGAAAACTGAAGAAGAGGAGCTTCAAAGAAATCTCTTAGAACTGGAGGTACAAAAAGAGCAGACCCTTGCTCAAATA GACTTTATGCAAAAACAAAGAAATAGAACTGAAGAGCTACTGGATCAGTTGAGCTTGTCTGAGTGGGATGTCGTTGAGTGGAGTGATGATCAAGCTGTAT TCACCTTTGTTTATGACACGATACAACTCACCATCACCTTTGAAGAGTCAGTTGTTGGTTTCCCTTTCCTGGACAAGCGTTATAGGAAGATTGTTGATGT CAATTTTCAATCTCTGTTAGATGAGGATCAAGCTCCTCCTTCCTCCCTTTTAGTTCATAAGCTTATTTTCCAGTACGTTGAAGAAAAGGAATCCTGGAAG AAGACATGTACAACCCAGCATCAGTTACCCAAGATGCTTGAAGAATTCTCACTGGTAGTGCACCATTGCAGACTCCTTGGAGAGGAGATTGAGTATTTAA AGAGATGGGGACCAAATTATAACCTAATGAACATAGATATTAATAATAATGAATTGAGACTTTTATTCTCTAGCTCCGCAGCATTTGCAAAGTTTGAAAT AACTTTGTTTCTCTCAGCCTATTATCCATCTGTACCATTACCTTCCACCATTCAGAATCACGTTGGGAACACTAGCCAAGATGATATTGCTACCATTCTA TCTAAAGTGCCACTGGAGAACAACTACCTGAAGAATGTAGTCAAGCAAATTTACCAAGATCTGTTTCAGGACTGCCATTTCTACCACTAGACCCTTGGAC CACCATTGGAACAACCAAGCAGAATGTACTTGATATTATTTCAGGGTCCCATTGCTGTTCAGCCTTTGTTTTTACGTCATTACAAGCTGAGTAAAATTCC TTCTGATGATGTTATAGTTAATCTGTATGTTTTTTATATCTCTGCAGAATGATGGTGATGAAGTCTGGATGGTAGGCCTCATAGCCTACTATCAACTTAC TCATCTTTGTACCAAAGGTTTAAGTAATAGGACACTTAGGAAAAATGTCTCCTAACTAAACTAGTGCTTTCTGCTTTAGTACAAGCCCTAAGGATTAACT TAAGTATAAGAAGTGTTATCACTGACAAGAACATTAGCCATTTTCCCATAACTAGATAGAGCTATGATTTTTTAGGTTGCCTGGCTTCTGCCTAGCAGAT ATTTCTGGAGTAGAAATGTATCTGTCTACAAACTATTATCCTTTTTCTCCGTTACTAAAATGCTATTAAGAGAAAGTAGGGCTGGGTGTGAGCCACCACA CCCAGCAATGTTTTCTTAATAAGTATAGTTTTTCTAGGGAAAGTTAATTCATTTTTGTCTAGTACATATATGTAAATATATTAATGTTGTTTTTGTGTTT GTGATGTAGTAAGGAGATGTACATAGAAATTCATTGAGGTATATAGATACTCATCTGTCTAGGCAGTTCCCAATTTTCTGAAGAATGTTTTACAGCAAAA TTTTCTATTTTCTTTTATTAAATAGTGACACGTCAAACAATGTCACATCCAAAACACTAGTTTCATCAATTTCTAGCAGTAATAATAGACTTGCTGTAAG TATTGTTTTCTGATGCCATACCCTTGTCATACATATTATTAAATGACCAATATTATGTATGAAGTAGACAAAAAAATTTACTCAAACTTCATTCAAATCC TAATTGTGATAATTTTTGTTTTATATTTAATTATAAACCAAAATACATTTGCATTTTTAAGCTAATTTGTCTCAAAATTTTGCTTTATATTTTTGGATCA GGTTAAAGTCCTGTGGATCCCCTGAATGTTATTGTCCCTCTTGATTGGTTTTTACTTCTGAGCTATACGTCAAAAGACACATAAGCTTCAAAAGTCAAGA CAAACCTCATTTGCCATAAAAATCAAGATATAGATGTTCTGTTCCGTAAACTCCTTGAAAAACATTTTAAAGTCATCAATATGATCTGTTTCCCATGAAA CTTAAGTTAGCTTTCTTATTGGAGTTATTTCTTTTCTGTAAGTCTGAAAAGTAGAGATTTTGTTTTACGCATTTTAGTAACCTGCAACAACCAACTCTAA AAAAGATTTGGCTTGTAATGACGGTCTCTGCTTTTTTGGGTTTGGAGTACACAATTGTAATATTTACTTAGTTATTTGTGTTTTTCTTTGTTCAAGGTAT TGACTAGTTTCATAAATTTTTTGAAAGTTTTTCTTTCATTGGTTGGAAAGCAGATTACATTTTGCACTATTAAAATAAGTTTATTACTTTAAA

refseq_CASC5.F1 (forward primer)
refseq_CASC5.R1 (reverse primer)
Single exon skipping

Frame 0

RFEYFTEASRAL*ADC*RRLSVSALRKLRACGP QTSLRKICRGGLPRQKSFLQKWMGCLQRLMKKMT I*RDLLEDGILQY*NPQGVLFRTSEVGMKEFRN PML*EIRKTLVESALQIL*RYSRRSLI*K**ES QKWKAAVQWCHLSCNFCLLGLSDSPASASQKQKQ EKIFF*YRIRN*KIITVKLLG*THCFLLPFIPR CNRRSFQL*NIPVKGNMQMTRQSFFQMKTRWT* HQVTL**LPKAF*IIP*VKSPPR*IPHHF*LI*S FTPRTQE*KKK*IFPWIKTLLQKIK*ISMTS*K D*KQENVVLFLMCLIKKILRYLFIPRNRTVPLL HIKCMYLLRKMKITVILLGSLEKKMMG*ISPSVI QPIFRH*FPHPVRPTHGNLKVMILQFMAMTLWT *HLTTLCRSYLQQVIFLK*KIKLRMPWM*QQVM ELKLQEIKQFLRVNKILLFKTFP*TLQTKYILPE VILWGQKLT*SHRLVIRMPEY*P*PQNLYILIH LFKVVRLFSILVVMMPWK*PNVSQI*ERRKIC* SMTVIMLKCIAIQMLCLLSQRKLFIPERRTWTLP RVIQLQ*IIKFLNKINQMCK*QLHQHPKKK*CS KIL*PHQKMGK*M*IVTQFLMYLRKEYSRACQI LCLFH*LIERLNSYQVKIWI*LKVTQVT*EVRFL LQLII*HRRVPVNLTLRAKALQMNVKKLPKVVM NHFSDQT**PKTA*PTPGTKTKIGF*RFCPTLI KILLSQLIVIRR*QQAII*STVVEFLINK*LIEI QYHGNNLCFLPQSHYFHQDSSL*KIMILL*VVI Q*NLY*ARILNWLSH*GKV*AIPHLTIAMTR*L YVQRKSKIWI*QRATLSSLDLVLLNYKNLVKLI* NTLLAS*QQ*TDR*L*KLKNVVKVP*KKVECLN LTVLWMC*RTKVYRNLNFQRKSKMSKFGEGKVL VDQKLIRLLYFQKTIRMIWISLRVIQ*K*TIDLY *RNVIVIWCHWQELLKLFYIHVGRMTWRSLEVT QLP*NVKLSHQMK*LLGLWTKL*CL*IIMLN*K *QSPILFSLTTKKRKEQTDLTLNYPKGKA*EHQQ *YVLLLRRVFSFQEMVKVTV**QMTAS*PLWRN GLIIGAL*R*LITWNCLNQPLAKTSKMYKVLDF *MNLYQAKVREEKALS*KMTRPLYFQRIIKMIWI LPRVVWWK*ITKVPWRIKRTSIWQGLLKLFCIH VGRMTWRSLGVTQLP*NVKLSCQMK*LLGPWTK PYCSQIITVIWKSPIPILFSLTVKPQRKYLKKTL NLE*EKEKTWVFPFLRIIAVFKKSLKNKHWL*E TK*FFTPSKSNNSLLLLIELLMKSSNFIVLLWM KRS*GKL*TRPVHWKKRKLKAVS*IIEIEEMWTL QVVMQLLFVDPVIIIPVYQMLFPVLIIWRVVPC SYVIKMRKKPIIAQCKMILLMQMILPVNITWNL RDSLSLLLVLC*RRKKLFKPVPKDS*TVL*HCTK IKI*LRIHEIYWLIKL*YIVKIWGR*LNLIQSE YLLSFQRIK*KSMLMTFMLFLSLISQPTNLHYL KKDRVVSIKKK*YCLKLEIRV*IL*KIPLHPYVK TSPKYSIVRNGLLQPVKKN*RKIFKQLTIIQL* ISTVTQT*LSKSFKLMSMLEKHQIL*LHLMFHV FIVSNQI*II*MEKLESF*PFKLFIYHPFQSNYL N*EIRHTMICI*CKLQKYIILT*SPAMLKIVEM RKIKSLIMELKPPLYRQRQFLKIK*GDVLWESF CLDCPTREIVVSLVLMTWNRFQQTQLI*IT*KLS RSLAKIQALDLLQVN*T*VLLNI*MRKIFLYIL MRSILQTLLT*KLRKRP*LRHTKKRFHHMKIKW EKLAIAKKERGYKKKKIFIRRKKSEKMRLSLVIR HKIGRFLITILKRI*IKVLTVY**KT*AGPHLV AAALWIQSRLMGPLWTSALTAVVKWNHSFSEIL FVKRA*GRNSKMGE*Q*GSSLYFSRSTS*YRNPD RAISQAILL*THHLLQKT*C*VNMFTDPRYRFI EKIVRLVAKRLKN*SFLHRTKISCWLI*IRTCG KK*DTALTKS*RPLEFILTK*SHVLPR*LKSSLT KEKWLCMASWCSQLRMRGRNFK*R*MRWIKYLR RSITASLRWKQKLRIWRMKRKTILWKNGILK*E LQKKNWNS*KLKKRSFKEIS*NWRYKKSRPLLK* TLCKNKEIELKSYWIS*ACLSGMSLSGVMIKLY SPLFMTRYNSPSPLKSQLLVSLSWTSVIGRLLM SIFNLC*MRIKLLLPPF*FISLFSSTLKKRNPGR RHVQPSISYPRCLKNSHW*CTIADSLERRLSI* RDGDQIIT**T*ILIIMN*DFYSLAPQHLQSLK *LCFSQPIIHLYHYLPPFRITLGTLAKMILLPFY LKCHWRTTT*RM*SSKFTKICFRTAISTTRPLD HHWNNQAECT*YYFRVPLLFSLCFYVITS*VKF LLMML*LICMFFISLQNDGDEVWMVGLIAYYQLT HLCTKGLSNRTLRKNVS*LN*CFLL*YKP*GLT *V*EVLSLTRTLAIFP*LDRAMIF*VAWLLPSR YFWSRNVSVYKLLSFFSVTKMLLRESRAGCEPPH PAMFS**V*FF*GKLIHFCLVHICKYINVVFVF VM**GDVHRNSLRYIDTHLSRQFPIF*RMFYSK IFYFLLLNSDTSNNVTSKTLVSSISSSNNRLAVS IVF*CHTLVIHIIK*PILCMK*TKKFTQTSFKS *L**FLFYI*L*TKIHLHF*ANLSQNFALYFWI RLKSCGSPECYCPS*LVFTSELYVKRHISFKSQD KPHLP*KSRYRCSVP*TP*KTF*SHQYDLFPMK LKLAFLLELFLFCKSEK*RFCFTHFSNLQQPTL KKIWLVMTVSAFLGLEYTIVIFT*LFVFFFVQGI D*FHKFFESFSFIGWKADYILHY*NKFITL

Frame 1

DLNTSLRRAGRCERTARGGCLFPL*GNSERVDP KQVCAKFVEEVCRGRKVFFKNGWGVFRG**RK* QYRETC*KTAFFNIETPKESSSGPQRWE*KSSGI QCFEK*EKLSSSQLCRYYKGIPDGVSYENSEKV RNGRLQCNGAISAATSASWV*AILLPQPPRNRN RRKSSFDTE*EIRR*LL*NYWDEHIAFCSHSYPD ATEGVFNYRTYP*KETCK*PDSHFFR*KPDGPD IKSHCNDYQRPFR*SHK*KVHQDRYHIISS*FK ASHRGLKNEKRSKFFRGSKHFFRK*NRFQ*LHKK IENRKM*CFS*CA**RKF*DTYLFQGTEQCLFY TSNACIS*GR*K*Q*YY*AL*RKR*WDEFHPVS YSQYSDIDSHIQ*DQLTGI*R**YYNLWQ*LYGL DI*PHFADLTCNR*FF*NRKSNSECHGCNNRLW N*SFRK*NSF*E*TKYCFSRPFHKLCRQNTYYQ KSYYGGRNSHSLTDL*SGCQNISHDPRIYIF*SI YSRL*DCFLF*L**CHGNDQMSLKYERGEKFAK A*Q*LC*NVLQSRCYVFSHRENYLFRRGEHGHY QESYSCNR*SNF*TRSIKCANSSCTNTRKRNDAP KSYDHIRRWENECKL*LSSSCI*GKNTAEPVKS FVYFID**KD*TLIR*KYGFD*KSHK*LRKSGS SCSL*SSTGEYQ*ISLSEQKLFR*M*RNYQKS** TISAIRHNSQKQLNRHLEQRQRLGFEDFALP** RFSSVS*L*SGDSNKP*YSLLWWSS**TNN**K YSIMGTIFVFYHKAIIFIRTVLYEKS*YCYK*SY SEICTRPEF*TG*ATEEKFKQSHT*LLP*QDDY MFRGRAKYGSNKEPHCRHWIWSF*TTRTW*N*F RTHYWPANNNEQTDSCKS*KMW*KSHRKKWSA*I *LYYGCVRGRKCTET*ISKGKAKCQNLGKEKCW WTKN**DYCIFRRR*E*YGYH*ELYNRNKP*TF IRET*LSFGAIGRNF*NYFIYM*AG*HGDH*KSH NCLRM*NCLTR*NNY*AYGQNCSVCR*SC*TRN DRVPYCFH*LPRKGKNRQT*L*TIPKEKPRNTN SDMYSY*GECFLSRKW*K*PSSSK*QPANPSGGM V***GPCRGS**HGIV*ISHLQKHQRCTKSWIS E*TSIKQKSEKKKP*AKK*QDHCIFRES*K*YG YYPELYGGNR*RKCPGG*RGLPFGRGF*NYFVFM WAG*HGDH*ESHNCLRM*NSPAK*NSY*AHGQN RIVHR*LQ*SGSHRFPYCFH*LSSHRENT*RKP *IWNRKRKKLGCFLS*G**LCSRNR*KTSTGCRK QNSSSHRAKATTLCCY**NY**NHQIS*CCYG* KGHRESCRPGLYIGKSAS*KLSVK**R*KKCGL YK*SCNCCLWIQ**LFLFTKCYFLY**FGG*CHA LM**R*GKSQLLPSAK*SCLCK*FCQ*ILLGI* GTASLCSLSFVREGRSYSNQYQRTVRLCYNTAQ RSRSD*GSTKSIG*SNFSI*SRSGGDD*T*FKAS IF*ASKGSNESLC**HLCYSSASFLNRPTSIT* KRTE*YQ*RRSNTV*SWK*EFKYYRKFLCTHM* KQAQNTQ**GMVCCSL*KRTEGKYSNN*L*YSSR FPQ*LRRN*ASHSNSCQCWRSTRSCNYI*CSMF S*YQTKSE*FEWKNWRVFSLSNCSSTTPSRAIT *IRK*GTQ*YAYSASYRNT*Y*HNLQQC*R**R* GK*KVS*WS*NHLSTAKDSF*R*SKEMFFGNLF A*IAQQEKL*CHWY**PGTDSSRHN*YKSLRNS AGL*QRFRHWICCR*TEPKSFSIYK*GKSSCIS* *DQFFRLY*HRN*GKGLD*DIPKRDFTI*K*NG KNLQ*PKKNVGTRRRRYS*GEKNQKK*D*V**Y DTRSGDF*SPY*RGYR*KC*QCIDKKPEQDPI*L QQLSGFNQG*WDLSGLQHLPQ*SNGITVSQRYY L*RELEGETPRWENNNKGVLYTSPGPHLDTETP TEQSPRQFYCKHTTYSRRPDVKSICLPTQDTDL* RRL*GSSPKD*RIKAFCIEPR*AVG*YK*EPVG KNETLL*QRAEGLWNLS*QNKVMFYQDD*SLHS PRKSGSVWQAGAVSSE*EGETSNKDR*DG*NT*E DR*LPH*DGNRN*EFGG*REKQSCGRMGF*NES CRKRIGTAEN*RRGASKKSLRTGGTKRADPCSN RLYAKTKK*N*RATGSVELV*VGCR*VE**SSCI HLCL*HDTTHHHL*RVSCWFPFPGQAL*EDC*C QFSISVR*GSSSSFLPFSS*AYFPVR*RKGILE EDMYNPASVTQDA*RILTGSAPLQTPWRGD*VFK EMGTKL*PNEHRY****IETFIL*LRSICKV*N NFVSLSLLSICTITFHHSESRWEH*PR*YCYHS I*SATGEQLPEECSQANLPRSVSGLPFLPLDPWT TIGTTKQNVLDIISGSHCCSAFVFTSLQAE*NS F**CYS*SVCFLYLCRMMVMKSGW*AS*PTINL LIFVPKV*VIGHLGKMSPN*TSAFCFSTSPKD*L KYKKCYH*QEH*PFSHN*IEL*FFRLPGFCLAD ISGVEMYLSTNYYPFSPLLKCY*EKVGLGVSHH TQQCFLNKYSFSRES*FIFV*YIYVNILMLFLCL *CSKEMYIEIH*GI*ILICLGSSQFSEECFTAK FSIFFY*IVTRQTMSHPKH*FHQFLAVIIDLL* VLFSDAIPLSYILLNDQYYV*SRQKNLLKLHSNP NCDNFCFIFNYKPKYICIFKLICLKILLYIFGS G*SPVDPLNVIVPLDWFLLLSYTSKDT*ASKVK TNLICHKNQDIDVLFRKLLEKHFKVINMICFP*N LS*LSYWSYFFSVSLKSRDFVLRILVTCNNQL* KRFGL**RSLLFWVWSTQL*YLLSYLCFSLFKV LTSFINFLKVFLSLVGKQITFCTIKISLLL*

Frame 2

I*ILH*GEPGVVSGLLEAAVCFRSKETQSVWTP NKSAQNLSRRFAAAEKFSSKMDGVSSEANEEND NIERPVRRRHSSILKPPRSPLQDLRGGNERVQE SNALRNKKNSRRVSFADTIKVFQTESHMKIVRKS EMEGCSAMVPSQLQLLPPGFKRFSCLSLPETET GENLLLIQNKKLEDNYCEITGMNTLLSAPIHTQ MQQKEFSIIEHTRERKHANDQTVIFSDENQMDLT SSHTVMITKGLLDNPISEKSTKIDTTSFLANLK LHTEDSRMKKEVNFSVDQNTSSENKIDFNDFIK RLKTGKCSAFPDVPDKENFEIPIYSKEPNSASST HQMHVSLKEDENNSNITRLFREKDDGMNFTQCH TANIQTLIPTSSETNSRESKGNDITIYGNDFMD LTFNHTLQILPATGNFSEIENQTQNAMDVTTGYG TKASGNKTVFKSKQNTAFQDLSINSADKIHITR SHIMGAETHIVSQTCNQDARILAMTPESIYSNP SIQGCKTVFYSSCNDAMEMTKCLSNMREEKNLLK HDSNYAKMYCNPDAMSSLTEKTIYSGEENMDIT KSHTVAIDNQIFKQDQSNVQIAAAPTPEKEMML QNLMTTSEDGKMNVNCNSVPHVSKERIQQSLSNP LSISLTDRKTELLSGENMDLTESHTSNLGSQVP LAAYNLAPESTSESHSQSKSSSDECEEITKSRN EPFQRSDIIAKNSLTDTWNKDKDWVLKILPYLDK DSPQSADCNQEIATSHNIVYCGGVLDKQITNRN TVSWEQSLFSTTKPLFSSGQFSMKNHDTAISSH TVKSVLGQNSKLAEPLRKSLSNPTPDYCHDKMII CSEEEQNMDLTKSHTVVIGFGPSELQELGKTNL EHTTGQLTTMNRQIAVKVEKCGKSPIEKSGVLK SNCIMDVLEDESVQKPKFPKEKQNVKIWGRKSVG GPKIDKTIVFSEDDKNDMDITKSYTIEINHRPL LEKRDCHLVPLAGTSETILYTCRQDDMEITRSH TTALECKTVSPDEITTRPMDKTVVFVDNHVELEM TESHTVFIDYQEKERTDRPNFELSQRKSLGTPT VICTPTEESVFFPGNGESDRLVANDSQLTPLEE WSNNRGPVEVADNMELSKSATCKNIKDVQSPGFL NEPLSSKSQRRKSLKLKNDKTIVFSENHKNDMD ITQSCMVEIDNESALEDKEDFHLAGASKTILYS CGQDDMEITRSHTTALECKTLLPNEIAIRPMDKT VLFTDNYSDLEVTDSHTVFIDCQATEKILEENP KFGIGKGKNLGVSFPKDNSCVQEIAEKQALAVG NKIVLHTEQKQQLFAATNRTTNEIIKFHSAAMDE KVIGKVVDQACTLEKAQVESCQLNNRDRRNVDF TSSHATAVCGSSDNYSCLPNVISCTDNLEGSAM LLCDKDEEKANYCPVQNDLAYANDFASEYYLESE GQPLSAPCPLLEKEEVIQTSTKGQLDCVITLHK DQDLIKDPRNLLANQTLVYSQDLGEMTKLNSKR VSFKLPKDQMKVYVDDIYVIPQPHFSTDQPPLPK KGQSSINKEEVILSKAGNKSLNIIENSSAPICE NKPKILNSEEWFAAACKKELKENIQTTNYNTAL DFHSNSDVTKQVIQTHVNAGEAPDPVITSNVPCF HSIKPNLNNLNGKTGEFLAFQTVHLPPLPEQLL ELGNKAHNDMHIVQATEIHNINIISSNAKDSRD EENKKSHNGAETTSLPPKTVFKDKVRRCSLGIFL PRLPNKRNCSVTGIDDLEQIPADTTDINHLETQ PVSSKDSGIGSVAGKLNLSPSQYINEENLPVYP DEINSSDSINIETEEKALIETYQKEISPYENKMG KTCNSQKRTWVQEEEDIHKEKKIRKNEIKFSDT TQDREIFDHHTEEDIDKSANSVLIKNLSRTPSS CSSSLDSIKADGTSLDFSTYRSSQMESQFLRDTI CEESLREKLQDGRITIREFFILLQVHILIQKPR QSNLPGNFTVNTPPTPEDLMLSQYVYRPKIQIY REDCEARRQKIEELKLSASNQDKLLVDINKNLWE KMRHCSDKELKAFGIYLNKIKSCFTKMTKVFTH QGKVALYGKLVQSAQNEREKLQIKIDEMDKILK KIDNCLTEMETETKNLEDEEKNNPVEEWDSEMRA AEKELEQLKTEEEELQRNLLELEVQKEQTLAQI DFMQKQRNRTEELLDQLSLSEWDVVEWSDDQAV FTFVYDTIQLTITFEESVVGFPFLDKRYRKIVDV NFQSLLDEDQAPPSSLLVHKLIFQYVEEKESWK KTCTTQHQLPKMLEEFSLVVHHCRLLGEEIEYL KRWGPNYNLMNIDINNNELRLLFSSSAAFAKFEI TLFLSAYYPSVPLPSTIQNHVGNTSQDDIATIL SKVPLENNYLKNVVKQIYQDLFQDCHFYH*TLG PPLEQPSRMYLILFQGPIAVQPLFLRHYKLSKIP SDDVIVNLYVFYISAE*W**SLDGRPHSLLSTY SSLYQRFK**DT*EKCLLTKLVLSALVQALRIN LSIRSVITDKNISHFPITR*SYDFLGCLASA*QI FLE*KCICLQTIILFLRY*NAIKRK*GWV*ATT PSNVFLISIVFLGKVNSFLSSTYM*IY*CCFCV CDVVRRCT*KFIEVYRYSSV*AVPNFLKNVLQQN FLFSFIK**HVKQCHIQNTSFINF*Q***TCCK YCFLMPYPCHTYY*MTNIMYEVDKKIYSNFIQI LIVIIFVLYLIINQNTFAFLS*FVSKFCFIFLDQ VKVLWIP*MLLSLLIGFYF*AIRQKTHKLQKSR QTSFAIKIKI*MFCSVNSLKNILKSSI*SVSHE T*VSFLIGVISFL*V*KVEILFYAF**PATTNSK KDLACNDGLCFFGFGVHNCNIYLVICVFLCSRY *LVS*IF*KFFFHWLESRLHFALLK*VYYFK