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Sequences

Sequence NM_021574

GGGGGGAGGGTGGCGGCTCGATGGGGGAGCCGCCTCCAGGGGGCCCCCCCGCCCTGTGCCCACGGCGCGGCCCCTTTAAGAGGCCCGCCTGGCTCCGTCA TCCGCGCCGCGGCCACCTCCCCCCGGCCCTCCCCTTCCTGCGGCGCAGAGTGCGGGCCGGGCGGGAGTGCGGCGAGAGCCGGCTGGCTGAGCTTAGCGTC CGAGGAGGCGGCGGCGGCGGCGGCGGCACGGCGGCGGCGGGGCTGTGGGGCGGTGCGGAAGCGAGAGGCGAGGAGCGCGCGGGCCGTGGCCAGAGTCTGG CGGCGGCCTGGCGGAGCGGAGAGCAGCGCCCGCGCCTCGCCGTGCGGAGGAGCCCCGCACACAATAGCGGCGCGCGCAGCCCGCGCCCTTCCCCCCGGCG CGCCCCGCCCCGCGCGCCGAGCGCCCCGCTCCGCCTCACCTGCCACCAGGGAGTGGGCGGGCATTGTTCGCCGCCGCCGCCGCCGCGCGGGCCATGGGGG CCGCCCGGCGCCCGGGGCCGGGCTGGCGAGGCGCCGCGCCGCCGCTGAGACGGGCCCCGCGCGCAGCCCGGCGGCGCAGGTAAGGCCGGCCGCGCCATGG TGGACCCGGTGGGCTTCGCGGAGGCGTGGAAGGCGCAGTTCCCGGACTCAGAGCCCCCGCGCATGGAGCTGCGCTCAGTGGGCGACATCGAGCAGGAGCT GGAGCGCTGCAAGGCCTCCATTCGGCGCCTGGAGCAGGAGGTGAACCAGGAGCGCTTCCGCATGATCTACCTGCAGACGTTGCTGGCCAAGGAAAAGAAG AGCTATGACCGGCAGCGATGGGGCTTCCGGCGCGCGGCGCAGGCCCCCGACGGCGCCTCCGAGCCCCGAGCGTCCGCGTCGCGCCCGCAGCCAGCGCCCG CCGACGGAGCCGACCCGCCGCCCGCCGAGGAGCCCGAGGCCCGGCCCGACGGCGAGGGTTCTCCGGGTAAGGCCAGGCCCGGGACCGCCCGCAGGCCCGG GGCAGCCGCGTCGGGGGAACGGGACGACCGGGGACCCCCCGCCAGCGTGGCGGCGCTCAGGTCCAACTTCGAGCGGATCCGCAAGGGCCATGGCCAGCCC GGGGCGGACGCCGAGAAGCCCTTCTACGTGAACGTCGAGTTTCACCACGAGCGCGGCCTGGTGAAGGTCAACGACAAAGAGGTGTCGGACCGCATCAGCT CCCTGGGCAGCCAGGCCATGCAGATGGAGCGCAAAAAGTCCCAGCACGGCGCGGGCTCGAGCGTGGGGGATGCATCCAGGCCCCCTTACCGGGGACGCTC CTCGGAGAGCAGCTGCGGCGTCGACGGCGACTACGAGGACGCCGAGTTGAACCCCCGCTTCCTGAAGGACAACCTGATCGACGCCAATGGCGGTAGCAGG CCCCCTTGGCCGCCCCTGGAGTACCAGCCCTACCAGAGCATCTACGTCGGGGGCATGATGGAAGGGGAGGGCAAGGGCCCGCTCCTGCGCAGCCAGAGCA CCTCTGAGCAGGAGAAGCGCCTTACCTGGCCCCGCAGGTCCTACTCCCCCCGGAGTTTTGAGGATTGCGGAGGCGGCTATACCCCGGACTGCAGCTCCAA TGAGAACCTCACCTCCAGCGAGGAGGACTTCTCCTCTGGCCAGTCCAGCCGCGTGTCCCCAAGCCCCACCACCTACCGCATGTTCCGGGACAAAAGCCGC TCTCCCTCGCAGAACTCGCAACAGTCCTTCGACAGCAGCAGTCCCCCCACGCCGCAGTGCCATAAGCGGCACCGGCACTGCCCGGTTGTCGTGTCCGAGG CCACCATCGTGGGCGTCCGCAAGACCGGGCAGATCTGGCCCAACGATGGCGAGGGCGCCTTCCATGGAGACGCAGATGGCTCGTTCGGAACACCACCTGG ATACGGCTGCGCTGCAGACCGGGCAGAGGAGCAGCGCCGGCACCAAGATGGGCTGCCCTACATTGATGACTCGCCCTCCTCATCGCCCCACCTCAGCAGC AAGGGCAGGGGCAGCCGGGATGCGCTGGTCTCGGGAGCCCTGGAGTCCACTAAAGCGAGTGAGCTGGACTTGGAAAAGGGCTTGGAGATGAGAAAATGGG TCCTGTCGGGAATCCTGGCTAGCGAGGAGACTTACCTGAGCCACCTGGAGGCACTGCTGCTGCCCATGAAGCCTTTGAAAGCCGCTGCCACCACCTCTCA GCCGGTGCTGACGAGTCAGCAGATCGAGACCATCTTCTTCAAAGTGCCTGAGCTCTACGAGATCCACAAGGAGTTCTATGATGGGCTCTTCCCCCGCGTG CAGCAGTGGAGCCACCAGCAGCGGGTGGGCGACCTCTTCCAGAAGCTGGCCAGCCAGCTGGGTGTGTACCGGGCCTTCGTGGACAACTACGGAGTTGCCA TGGAAATGGCTGAGAAGTGCTGTCAGGCCAATGCTCAGTTTGCAGAAATCTCCGAGAACCTGAGAGCCAGAAGCAACAAAGATGCCAAGGATCCAACGAC CAAGAACTCTCTGGAAACTCTGCTCTACAAGCCTGTGGACCGTGTGACGAGGAGCACGCTGGTCCTCCATGACTTGCTGAAGCACACTCCTGCCAGCCAC CCTGACCACCCCTTGCTGCAGGACGCCCTCCGCATCTCACAGAACTTCCTGTCCAGCATCAATGAGGAGATCACACCCCGACGGCAGTCCATGACGGTGA AGAAGGGAGAGCACCGGCAGCTGCTGAAGGACAGCTTCATGGTGGAGCTGGTGGAGGGGGCCCGCAAGCTGCGCCACGTCTTCCTGTTCACCGACCTGCT TCTCTGCACCAAGCTCAAGAAGCAGAGCGGAGGCAAAACGCAGCAGTATGACTGCAAATGGTACATTCCGCTCACGGATCTCAGCTTCCAGATGGTGGAT GAACTGGAGGCAGTGCCCAACATCCCCCTGGTGCCCGATGAGGAGCTGGACGCTTTGAAGATCAAGATCTCCCAGATCAAGAATGACATCCAGAGAGAGA AGAGGGCGAACAAGGGCAGCAAGGCTACGGAGAGGCTGAAGAAGAAGCTGTCGGAGCAGGAGTCACTGCTGCTGCTTATGTCTCCCAGCATGGCCTTCAG GGTGCACAGCCGCAACGGCAAGAGTTACACGTTCCTGATCTCCTCTGACTATGAGCGTGCAGAGTGGAGGGAGAACATCCGGGAGCAGCAGAAGAAGTGT TTCAGAAGCTTCTCCCTGACATCCGTGGAGCTGCAGATGCTGACCAACTCGTGTGTGAAACTCCAGACTGTCCACAGCATTCCGCTGACCATCAATAAGG AAGATGATGAGTCTCCGGGGCTCTATGGGTTTCTGAATGTCATCGTCCACTCAGCCACTGGATTTAAGCAGAGTTCAAATCTGTACTGCACCCTGGAGGT GGATTCCTTTGGGTATTTTGTGAATAAAGCAAAGACGCGCGTCTACAGGGACACAGCTGAGCCAAACTGGAACGAGCTGGACCCGCAGGCCCTGCAGGAC AGAGACTGGCAGCGCACCGTCATCGCCATGAATGGGATCGAAGTAAAGCTCTCGGTCAAGTTCAACAGCAGGGAGTTCAGCTTGAAGAGGATGCCGTCCC GAAAACAGACAGGGGTCTTCGGAGTCAAGATTGCTGTGGTCACCAAGAGAGAGAGGTCCAAGGTGCCCTACATCGTGCGCCAGTGCGTGGAGGAGATCGA GCGCCGAGGCATGGAGGAGGTGGGCATCTACCGCGTGTCCGGTGTGGCCACGGACATCCAGGCACTGAAGGCAGCCTTCGACGTCAATAACAAGGACGTG TCGGTGATGATGAGCGAGATGGACGTGAACGCCATCGCAGGCACGCTGAAGCTGTACTTCCGTGAGCTGCCCGAGCCCCTCTTCACTGACGAGTTCTACC CCAACTTCGCAGAGGGCATCGCTCTTTCAGACCCGGTTGCAAAGGAGAGCTGCATGCTCAACCTGCTGCTGTCCCTGCCGGAGGCCAACCTGCTCACCTT CCTTTTCCTTCTGGACCACCTGAAAAGGGTGGCAGAGAAGGAGGCAGTCAATAAGATGTCCCTGCACAACCTCGCCACGGTCTTTGGCCCCACGCTGCTC CGGCCCTCCGAGAAGGAGAGCAAGCTCCCTGCCAACCCCAGCCAGCCTATCACCATGACTGACAGCTGGTCCTTGGAGGTCATGTCCCAGGTCCAGGTGC TGCTGTACTTCCTGCAGCTGGAGGCCATCCCTGCCCCGGACAGCAAGAGACAGAGCATCCTGTTCTCCACCGAAGTCTAAAGGTCCCAGTCCATCTCCTG GAGGCGGACAGATGGCCTGGAAACCTCTGGCTAATCGGGCCATCCGTAGAGCGGGAACCTTCCTGAGGTGTCCTTGGGCCACCCCCAAGTGTTGGGCCAT CTGCCAAGAGACAGCGACCCAAAGCCGAAGGACAGGTGGCCTGGAAAGATCCCGCCCAGGTCTGGGAGCCCCAGGCTGGCCTCAGACTGTGGTTTTTTAT GTGGCCACCTGAGGGCGCCCCAAGCCAGTTCATCTCGGAGTCCAGGCCTGGCCCTGGGAGACAGGGTGAAGGGAGTGGTTTTTATGAACTTAACTTAGAG TCTAAAAGATTTCTACTGGATCACTTGTCAAGATGCGCCCTCTCTGGGGAGAAGGGAACGTGACTGGATTCCCTCACTGTTGTATCTTGAATAAACGCTG CTGCTTCATCCTGTGGGGGCCGTGGCCCTGTCCCTGTGTGGGTGGGGCCTCTTCCATTTCCCTGACTTAGAAACCACACTCCACTTCTAACAGGGTTTGA GAGGCTTAGTCAGCACTGGGTAGCGTTTTGACTCCATTCTTGGCTTTCTTTTTCTTTCCAGAAGGATTTTTGTGCAGAAATGGGTCTTTTGTTGCCATGT TAGTCCTCCTTGGAAGGCAGCTCAGAAGGCCTGTGAAATGTCAGGGGACAGGACCCCCAGGGAGGGAACCCCAGGCTACGCACTTTAGGGTTCGTTCTCC AGGGAGAGCGACCTCGTCCCCCGATCCTGACCGCCCTTCCGGCCCACGCTCTCCTGTTTGGCTTCCACAGGCCTGGACTTCTCTGGCTTCTCTGCCCACA CACTCCCTGCCCCCAGTGTCCCTGCCCCTGCCCCAGCACAGGTGACTTCATTTCTGTCCTCTCAGCTCAGTGGACTCGCTCAACTTTTGTATAAGTCTCC ACTTGGTGGCAGCAGCTTGCTGATGACTTGTTTTAAAACTTTCATCCTAAATAACCTTTTGATACTTGAATATTTGTAAGTTTTATACATAGTTTCTAAT TTTTTTCCGAACAGATCCAGATACCTAATAAGATGCTGGAATGTAATCCCTGGACAATCCGTGTCCTGGCAGCATTTGGTCTTCCTCTAAGCGCCTGGCT CCGCTGTTCTCAGGAGTGGGTTCTGAAGTCTCTGGAGAACAGGATACGTGGAGGGTTAGGAAGGGGCCAGGCCTAGAGACGGGAGACTCCCTCCCGGAGC AGGTGGAGGCACAGGACCATTCGCTACCCCATCTGCCGACACCTGCGGGGGAGCCCAGGCATTCTTTGTAAACCCTCCTGACCACCTGGCTCAAAGAAAA CAGAAGCATGGAGACCGCCAAGTATTTTCAAGAAATAACCCCATGAATATTCCATCACTTTTTTAGAAAGAGGGGCTTGGGGCAGGCAGAGGAGAGAAGG GAGAGCAAACTGAGAGCCAAGTTTCCACACGGTCCTGCAGGAGGAGAGGATGCAGCTGCCCAGAGGGAAGCAGGATCACATTTAAGGAAGTGTGTGGGGT CCCTGGATGACACCAGCACCCAGTGCGGCTCTGTCTGGCACCCGCTCCCAAGGTGGGAGGAGTGGGTGTCCCCTGTGTGTCAGTGGGCAGCTCCTGCTGA ACCCGCAGCTCACTAGGGAGCCTGACAGTGGGGCCATGCGCCTGACACTCCTCTCTGCTTGTGGACCTGGCAAGGCAGGGAGCAGAAAACAGCCACTTGA AGGCTTTCTGTCTGCGTCTGTGTGCAGTGTGGATTTAGTTGTGCTTTTTTCTTGCTGGGAGAGCACAGCCACCATTTACAAGCAGTGTCACCGTCGTGGG TGGCGAGGACAGAACAGGAGCCTCTGCTCTCTGTACCTATCTGGGCCCGGTGGGCTCCCTTGTCCTGGCTTCCATCTCTGTCTCAGCGACCATTCAGCCC TGCGCAGGAACACGTGTTGCTTAGAAAAGCCAAATCCAGCCTTGTCTCTGCCTCCTCTGGTCTCATGATGTGCATCTGTTACCTTGAAACTGGAAACCAG TCTATCAATGTCTGTGCCAATTTTTTATTCCCTCCCCAACCTCCTTCCCCATACGACTTTTTATTTATGTAGGATGTGTGCTGTCTAATGATGGGATGAC CACACTTTTCCATGTTCTAAAAGTGCTCCTCTCCCGCAGGGTCCCAGGGCTGGTGGTTGCTTTGGGTCTACAGCTACGTCTTACCCACCTCCTGCCTCAA CAGCCTGTGTGGTGGCAAAGCCGGTGTGGGGCTGGGGAACGCAGCGTTCTCCAGGAGGGGGACCTGGCTCTCCTTCTGCAATGCAGGCGAAGGCCTAGAT GCCAGTGTGACCTCCCACAAGGCGTGGCTTCCAGACTCCCCGGCCGGAAGTGATGCTTTTTTGCCTTGGGCCCTGGGTTTGAAGCAGCCTGGCTTTCTCT TGGTAAGTGGCTGGTGTCTTAGCAGCTGCAATCTGAGCTCAGCCACCTACACACCACCGTGGCCGACACTTTCATTAAAAAGTTTCCTGAGACGA

refseq_BCR.F1 (forward primer)
refseq_BCR.R1 (reverse primer)
Single exon skipping

Frame 0

GGRVAARWGSRLQGAPPPCAHGAAPLRGPPGSV IRAAATSPRPSPSCGAECGPGGSAARAGWLSLAS EEAAAAAAARRRRGCGAVRKREARSARAVARVW RRPGGAESSARASPCGGAPHTIAARAARALPPG APRPARRAPRSASPATREWAGIVRRRRRRAGHGG RPAPGAGLARRRAAAETGPARSPAAQVRPAAPW WTRWASRRRGRRSSRTQSPRAWSCAQWATSSRS WSAARPPFGAWSRR*TRSASA*STCRRCWPRKRR AMTGSDGASGARRRPPTAPPSPERPRRARSQRP PTEPTRRPPRSPRPGPTARVLRVRPGPGPPAGP GQPRRGNGTTGDPPPAWRRSGPTSSGSARAMASP GRTPRSPST*TSSFTTSAAW*RSTTKRCRTASA PWAARPCRWSAKSPSTARARAWGMHPGPLTGDA PRRAAAASTATTRTPS*TPAS*RTT*STPMAVAG PLGRPWSTSPTRASTSGA*WKGRARARSCAARA PLSRRSALPGPAGPTPPGVLRIAEAAIPRTAAP MRTSPPARRTSPLASPAACPQAPPPTACSGTKAA LPRRTRNSPSTAAVPPRRSAISGTGTARLSCPR PPSWASARPGRSGPTMARAPSMETQMARSEHHL DTAALQTGQRSSAGTKMGCPTLMTRPPHRPTSAA RAGAAGMRWSREPWSPLKRVSWTWKRAWR*ENG SCRESWLARRLT*ATWRHCCCP*SL*KPLPPPL SRC*RVSRSRPSSSKCLSSTRSTRSSMMGSSPAC SSGATSSGWATSSRSWPASWVCTGPSWTTTELP WKWLRSAVRPMLSLQKSPRT*EPEATKMPRIQR PRTLWKLCSTSLWTV*RGARWSSMTC*STLLPAT LTTPCCRTPSASHRTSCPASMRRSHPDGSP*R* RRESTGSC*RTASWWSWWRGPASCATSSCSPTC FSAPSSRSRAEAKRSSMTANGTFRSRISASRWWM NWRQCPTSPWCPMRSWTL*RSRSPRSRMTSRER RGRTRAARLRRG*RRSCRSRSHCCCLCLPAWPS GCTAATARVTRS*SPLTMSVQSGGRTSGSSRRSV SEASP*HPWSCRC*PTRV*NSRLSTAFR*PSIR KMMSLRGSMGF*MSSSTQPLDLSRVQICTAPWR WIPLGIL*IKQRRASTGTQLSQTGTSWTRRPCRT ETGSAPSSP*MGSK*SSRSSSTAGSSA*RGCRP ENRQGSSESRLLWSPRERGPRCPTSCASAWRRS SAEAWRRWASTACPVWPRTSRH*RQPSTSITRTC R***ARWT*TPSQAR*SCTSVSCPSPSSLTSST PTSQRASLFQTRLQRRAACSTCCCPCRRPTCSP SFSFWTT*KGWQRRRQSIRCPCTTSPRSLAPRCS GPPRRRASSLPTPASLSP*LTAGPWRSCPRSRC CCTSCSWRPSLPRTARDRASCSPPKSKGPSPSP GGGQMAWKPLANRAIRRAGTFLRCPWATPKCWAI CQETATQSRRTGGLERSRPGLGAPGWPQTVVFY VAT*GRPKPVHLGVQAWPWETG*REWFL*T*LR V*KISTGSLVKMRPLWGEGNVTGFPHCCILNKRC CFILWGPWPCPCVGGASSISLT*KPHSTSNRV* EA*SALGSVLTPFLAFFFFPEGFLCRNGSFVAM LVLLGRQLRRPVKCQGTGPPGREPQATHFRVRSP GRATSSPDPDRPSGPRSPVWLPQAWTSLASLPT HSLPPVSLPLPQHR*LHFCPLSSVDSLNFCISL HLVAAAC**LVLKLSS*ITF*YLNICKFYT*FLI FFRTDPDT**DAGM*SLDNPCPGSIWSSSKRLA PLFSGVGSEVSGEQDTWRVRKGPGLETGDSLPE QVEAQDHSLPHLPTPAGEPRHSL*TLLTTWLKEN RSMETAKYFQEITP*IFHHFFRKRGLGQAEERR ESKLRAKFPHGPAGGEDAAAQREAGSHLRKCVG SLDDTSTQCGSVWHPLPRWEEWVSPVCQWAAPAE PAAH*GA*QWGHAPDTPLCLWTWQGREQKTAT* RLSVCVCVQCGFSCAFFLLGEHSHHLQAVSPSW VARTEQEPLLSVPIWARWAPLSWLPSLSQRPFSP AQEHVLLRKAKSSLVSASSGLMMCICYLETGNQ SINVCANFLFPPQPPSPYDFLFM*DVCCLMMG* PHFSMF*KCSSPAGSQGWWLLWVYSYVLPTSCLN SLCGGKAGVGLGNAAFSRRGTWLSFCNAGEGLD ASVTSHKAWLPDSPAGSDAFLPWALGLKQPGFL LVSGWCLSSCNLSSATYTPPWPTLSLKSFLRR

Frame 1

GGGWRLDGGAASRGPPRPVPTARPL*EARLAPS SAPRPPPPGPPLPAAQSAGRAGVRREPAG*A*R PRRRRRRRRHGGGGAVGRCGSERRGARGPWPESG GGLAERRAAPAPRRAEEPRTQ*RRAQPAPFPPA RPAPRAERPAPPHLPPGSGRALFAAAAAARAMG AARRPGPGWRGAAPPLRRAPRAARRRR*GRPRHG GPGGLRGGVEGAVPGLRAPAHGAALSGRHRAGA GALQGLHSAPGAGGEPGALPHDLPADVAGQGKE EL*PAAMGLPARGAGPRRRLRAPSVRVAPAASAR RRSRPAARRGARGPARRRGFSG*GQARDRPQAR GSRVGGTGRPGTPRQRGGAQVQLRADPQGPWPA RGGRREALLRERRVSPRARPGEGQRQRGVGPHQL PGQPGHADGAQKVPARRGLERGGCIQAPLPGTL LGEQLRRRRRLRGRRVEPPLPEGQPDRRQWR*Q APLAAPGVPALPEHLRRGHDGRGGQGPAPAQPEH L*AGEAPYLAPQVLLPPEF*GLRRRLYPGLQLQ *EPHLQRGGLLLWPVQPRVPKPHHLPHVPGQKP LSLAELATVLRQQQSPHAAVP*AAPALPGCRVRG HHRGRPQDRADLAQRWRGRLPWRRRWLVRNTTW IRLRCRPGRGAAPAPRWAALH**LALLIAPPQQ QGQGQPGCAGLGSPGVH*SE*AGLGKGLGDEKMG PVGNPG*RGDLPEPPGGTAAAHEAFESRCHHLS AGADESADRDHLLQSA*ALRDPQGVL*WALPPR AAVEPPAAGGRPLPEAGQPAGCVPGLRGQLRSCH GNG*EVLSGQCSVCRNLREPESQKQQRCQGSND QELSGNSALQACGPCDEEHAGPP*LAEAHSCQP P*PPLAAGRPPHLTELPVQHQ*GDHTPTAVHDGE EGRAPAAAEGQLHGGAGGGGPQAAPRLPVHRPA SLHQAQEAERRQNAAV*LQMVHSAHGSQLPDGG *TGGSAQHPPGAR*GAGRFEDQDLPDQE*HPERE EGEQGQQGYGEAEEEAVGAGVTAAAYVSQHGLQ GAQPQRQELHVPDLL*L*ACRVEGEHPGAAEEV FQKLLPDIRGAADADQLVCETPDCPQHSADHQ*G R**VSGALWVSECHRPLSHWI*AEFKSVLHPGG GFLWVFCE*SKDARLQGHS*AKLERAGPAGPAG QRLAAHRHRHEWDRSKALGQVQQQGVQLEEDAVP KTDRGLRSQDCCGHQEREVQGALHRAPVRGGDR APRHGGGGHLPRVRCGHGHPGTEGSLRRQ*QGR VGDDERDGRERHRRHAEAVLP*AARAPLH*RVLP QLRRGHRSFRPGCKGELHAQPAAVPAGGQPAHL PFPSGPPEKGGREGGSQ*DVPAQPRHGLWPHAA PALREGEQAPCQPQPAYHHD*QLVLGGHVPGPGA AVLPAAGGHPCPGQQETEHPVLHRSLKVPVHLL EADRWPGNLWLIGPSVEREPS*GVLGPPPSVGP SAKRQRPKAEGQVAWKDPAQVWEPQAGLRLWFFM WPPEGAPSQFISESRPGPGRQGEGSGFYELNLE SKRFLLDHLSRCALSGEKGT*LDSLTVVS*INA AASSCGGRGPVPVWVGPLPFP*LRNHTPLLTGFE RLSQHWVAF*LHSWLSFSFQKDFCAEMGLLLPC *SSLEGSSEGL*NVRGQDPQGGNPRLRTLGFVL QGERPRPPILTALPAHALLFGFHRPGLLWLLCPH TPCPQCPCPCPSTGDFISVLSAQWTRSTFV*VS TWWQQLADDLF*NFHPK*PFDT*IFVSFIHSF* FFSEQIQIPNKMLECNPWTIRVLAAFGLPLSAWL RCSQEWVLKSLENRIRGGLGRGQA*RRETPSRS RWRHRTIRYPICRHLRGSPGILCKPS*PPGSKK TEAWRPPSIFKK*PHEYSITFLERGAWGRQRREG RAN*EPSFHTVLQEERMQLPRGKQDHI*GSVWG PWMTPAPSAALSGTRSQGGRSGCPLCVSGQLLL NPQLTREPDSGAMRLTLLSACGPGKAGSRKQPLE GFLSASVCSVDLVVLFSCWESTATIYKQCHRRG WRGQNRSLCSLYLSGPGGLPCPGFHLCLSDHSA LRRNTCCLEKPNPALSLPPLVS*CASVTLKLETS LSMSVPIFYSLPNLLPHTTFYLCRMCAV**WDD HTFPCSKSAPLPQGPRAGGCFGSTATSYPPPAS TACVVAKPVWGWGTQRSPGGGPGSPSAMQAKA*M PV*PPTRRGFQTPRPEVMLFCLGPWV*SSLAFS W*VAGVLAAAI*AQPPTHHRGRHFH*KVS*D

Frame 2

GEGGGSMGEPPPGGPPALCPRRGPFKRPAWLRH PRRGHLPPALPFLRRRVRAGRECGESRLAELSV RGGGGGGGGTAAAGLWGGAEARGEERAGRGQSL AAAWRSGEQRPRLAVRRSPAHNSGARSPRPSPRR APPRAPSAPLRLTCHQGVGGHCSPPPPPRGPWG PPGARGRAGEAPRRR*DGPRAQPGGAGKAGRAM VDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQEL ERCKASIRRLEQEVNQERFRMIYLQTLLAKEKK SYDRQRWGFRRAAQAPDGASEPRASASRPQPAP ADGADPPPAEEPEARPDGEGSPGKARPGTARRPG AAASGERDDRGPPASVAALRSNFERIRKGHGQP GADAEKPFYVNVEFHHERGLVKVNDKEVSDRIS SLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRS SESSCGVDGDYEDAELNPRFLKDNLIDANGGSR PPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQS TSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSN ENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSR SPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSE ATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPG YGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSS KGRGSRDALVSGALESTKASELDLEKGLEMRKW VLSGILASEETYLSHLEALLLPMKPLKAAATTSQ PVLTSQQIETIFFKVPELYEIHKEFYDGLFPRV QQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVA MEMAEKCCQANAQFAEISENLRARSNKDAKDPTT KNSLETLLYKPVDRVTRSTLVLHDLLKHTPASH PDHPLLQDALRISQNFLSSINEEITPRRQSMTV KKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLL LCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVD ELEAVPNIPLVPDEELDALKIKISQIKNDIQRE KRANKGSKATERLKKKLSEQESLLLLMSPSMAFR VHSRNGKSYTFLISSDYERAEWRENIREQQKKC FRSFSLTSVELQMLTNSCVKLQTVHSIPLTINK EDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEV DSFGYFVNKAKTRVYRDTAEPNWNELDPQALQD RDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPS RKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIE RRGMEEVGIYRVSGVATDIQALKAAFDVNNKDV SVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFY PNFAEGIALSDPVAKESCMLNLLLSLPEANLLTF LFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLL RPSEKESKLPANPSQPITMTDSWSLEVMSQVQV LLYFLQLEAIPAPDSKRQSILFSTEV*RSQSISW RRTDGLETSG*SGHP*SGNLPEVSLGHPQVLGH LPRDSDPKPKDRWPGKIPPRSGSPRLASDCGFL CGHLRAPQASSSRSPGLALGDRVKGVVFMNLT*S LKDFYWITCQDAPSLGRRERDWIPSLLYLE*TL LLHPVGAVALSLCGWGLFHFPDLETTLHF*QGL RGLVSTG*RFDSILGFLFLSRRIFVQKWVFCCHV SPPWKAAQKACEMSGDRTPREGTPGYAL*GSFS RESDLVPRS*PPFRPTLSCLASTGLDFSGFSAH TLPAPSVPAPAPAQVTSFLSSQLSGLAQLLYKSP LGGSSLLMTCFKTFILNNLLILEYL*VLYIVSN FFPNRSRYLIRCWNVIPGQSVSWQHLVFL*APG SAVLRSGF*SLWRTGYVEG*EGARPRDGRLPPGA GGGTGPFATPSADTCGGAQAFFVNPPDHLAQRK QKHGDRQVFSRNNPMNIPSLF*KEGLGAGRGEK GEQTESQVSTRSCRRRGCSCPEGSRITFKEVCGV PG*HQHPVRLCLAPAPKVGGVGVPCVSVGSSC* TRSSLGSLTVGPCA*HSSLLVDLARQGAENSHL KAFCLRLCAVWI*LCFFLAGRAQPPFTSSVTVVG GEDRTGASALCTYLGPVGSLVLASISVSATIQP CAGTRVA*KSQIQPCLCLLWSHDVHLLP*NWKP VYQCLCQFFIPSPTSFPIRLFIYVGCVLSNDGMT TLFHVLKVLLSRRVPGLVVALGLQLRLTHLLPQ QPVWWQSRCGAGERSVLQEGDLALLLQCRRRPR CQCDLPQGVASRLPGRK*CFFALGPGFEAAWLSL GKWLVS*QLQSELSHLHTTVADTFIKKFPET

Sequence NM_004327

GGGGGGAGGGTGGCGGCTCGATGGGGGAGCCGCCTCCAGGGGGCCCCCCCGCCCTGTGCCCACGGCGCGGCCCCTTTAAGAGGCCCGCCTGGCTCCGTCA TCCGCGCCGCGGCCACCTCCCCCCGGCCCTCCCCTTCCTGCGGCGCAGAGTGCGGGCCGGGCGGGAGTGCGGCGAGAGCCGGCTGGCTGAGCTTAGCGTC CGAGGAGGCGGCGGCGGCGGCGGCGGCACGGCGGCGGCGGGGCTGTGGGGCGGTGCGGAAGCGAGAGGCGAGGAGCGCGCGGGCCGTGGCCAGAGTCTGG CGGCGGCCTGGCGGAGCGGAGAGCAGCGCCCGCGCCTCGCCGTGCGGAGGAGCCCCGCACACAATAGCGGCGCGCGCAGCCCGCGCCCTTCCCCCCGGCG CGCCCCGCCCCGCGCGCCGAGCGCCCCGCTCCGCCTCACCTGCCACCAGGGAGTGGGCGGGCATTGTTCGCCGCCGCCGCCGCCGCGCGGGCCATGGGGG CCGCCCGGCGCCCGGGGCCGGGCTGGCGAGGCGCCGCGCCGCCGCTGAGACGGGCCCCGCGCGCAGCCCGGCGGCGCAGGTAAGGCCGGCCGCGCCATGG TGGACCCGGTGGGCTTCGCGGAGGCGTGGAAGGCGCAGTTCCCGGACTCAGAGCCCCCGCGCATGGAGCTGCGCTCAGTGGGCGACATCGAGCAGGAGCT GGAGCGCTGCAAGGCCTCCATTCGGCGCCTGGAGCAGGAGGTGAACCAGGAGCGCTTCCGCATGATCTACCTGCAGACGTTGCTGGCCAAGGAAAAGAAG AGCTATGACCGGCAGCGATGGGGCTTCCGGCGCGCGGCGCAGGCCCCCGACGGCGCCTCCGAGCCCCGAGCGTCCGCGTCGCGCCCGCAGCCAGCGCCCG CCGACGGAGCCGACCCGCCGCCCGCCGAGGAGCCCGAGGCCCGGCCCGACGGCGAGGGTTCTCCGGGTAAGGCCAGGCCCGGGACCGCCCGCAGGCCCGG GGCAGCCGCGTCGGGGGAACGGGACGACCGGGGACCCCCCGCCAGCGTGGCGGCGCTCAGGTCCAACTTCGAGCGGATCCGCAAGGGCCATGGCCAGCCC GGGGCGGACGCCGAGAAGCCCTTCTACGTGAACGTCGAGTTTCACCACGAGCGCGGCCTGGTGAAGGTCAACGACAAAGAGGTGTCGGACCGCATCAGCT CCCTGGGCAGCCAGGCCATGCAGATGGAGCGCAAAAAGTCCCAGCACGGCGCGGGCTCGAGCGTGGGGGATGCATCCAGGCCCCCTTACCGGGGACGCTC CTCGGAGAGCAGCTGCGGCGTCGACGGCGACTACGAGGACGCCGAGTTGAACCCCCGCTTCCTGAAGGACAACCTGATCGACGCCAATGGCGGTAGCAGG CCCCCTTGGCCGCCCCTGGAGTACCAGCCCTACCAGAGCATCTACGTCGGGGGCATGATGGAAGGGGAGGGCAAGGGCCCGCTCCTGCGCAGCCAGAGCA CCTCTGAGCAGGAGAAGCGCCTTACCTGGCCCCGCAGGTCCTACTCCCCCCGGAGTTTTGAGGATTGCGGAGGCGGCTATACCCCGGACTGCAGCTCCAA TGAGAACCTCACCTCCAGCGAGGAGGACTTCTCCTCTGGCCAGTCCAGCCGCGTGTCCCCAAGCCCCACCACCTACCGCATGTTCCGGGACAAAAGCCGC TCTCCCTCGCAGAACTCGCAACAGTCCTTCGACAGCAGCAGTCCCCCCACGCCGCAGTGCCATAAGCGGCACCGGCACTGCCCGGTTGTCGTGTCCGAGG CCACCATCGTGGGCGTCCGCAAGACCGGGCAGATCTGGCCCAACGATGGCGAGGGCGCCTTCCATGGAGACGCAGATGGCTCGTTCGGAACACCACCTGG ATACGGCTGCGCTGCAGACCGGGCAGAGGAGCAGCGCCGGCACCAAGATGGGCTGCCCTACATTGATGACTCGCCCTCCTCATCGCCCCACCTCAGCAGC AAGGGCAGGGGCAGCCGGGATGCGCTGGTCTCGGGAGCCCTGGAGTCCACTAAAGCGAGTGAGCTGGACTTGGAAAAGGGCTTGGAGATGAGAAAATGGG TCCTGTCGGGAATCCTGGCTAGCGAGGAGACTTACCTGAGCCACCTGGAGGCACTGCTGCTGCCCATGAAGCCTTTGAAAGCCGCTGCCACCACCTCTCA GCCGGTGCTGACGAGTCAGCAGATCGAGACCATCTTCTTCAAAGTGCCTGAGCTCTACGAGATCCACAAGGAGTTCTATGATGGGCTCTTCCCCCGCGTG CAGCAGTGGAGCCACCAGCAGCGGGTGGGCGACCTCTTCCAGAAGCTGGCCAGCCAGCTGGGTGTGTACCGGGCCTTCGTGGACAACTACGGAGTTGCCA TGGAAATGGCTGAGAAGTGCTGTCAGGCCAATGCTCAGTTTGCAGAAATCTCCGAGAACCTGAGAGCCAGAAGCAACAAAGATGCCAAGGATCCAACGAC CAAGAACTCTCTGGAAACTCTGCTCTACAAGCCTGTGGACCGTGTGACGAGGAGCACGCTGGTCCTCCATGACTTGCTGAAGCACACTCCTGCCAGCCAC CCTGACCACCCCTTGCTGCAGGACGCCCTCCGCATCTCACAGAACTTCCTGTCCAGCATCAATGAGGAGATCACACCCCGACGGCAGTCCATGACGGTGA AGAAGGGAGAGCACCGGCAGCTGCTGAAGGACAGCTTCATGGTGGAGCTGGTGGAGGGGGCCCGCAAGCTGCGCCACGTCTTCCTGTTCACCGACCTGCT TCTCTGCACCAAGCTCAAGAAGCAGAGCGGAGGCAAAACGCAGCAGTATGACTGCAAATGGTACATTCCGCTCACGGATCTCAGCTTCCAGATGGTGGAT GAACTGGAGGCAGTGCCCAACATCCCCCTGGTGCCCGATGAGGAGCTGGACGCTTTGAAGATCAAGATCTCCCAGATCAAGAATGACATCCAGAGAGAGA AGAGGGCGAACAAGGGCAGCAAGGCTACGGAGAGGCTGAAGAAGAAGCTGTCGGAGCAGGAGTCACTGCTGCTGCTTATGTCTCCCAGCATGGCCTTCAG GGTGCACAGCCGCAACGGCAAGAGTTACACGTTCCTGATCTCCTCTGACTATGAGCGTGCAGAGTGGAGGGAGAACATCCGGGAGCAGCAGAAGAAGTGT TTCAGAAGCTTCTCCCTGACATCCGTGGAGCTGCAGATGCTGACCAACTCGTGTGTGAAACTCCAGACTGTCCACAGCATTCCGCTGACCATCAATAAGG AAGATGATGAGTCTCCGGGGCTCTATGGGTTTCTGAATGTCATCGTCCACTCAGCCACTGGATTTAAGCAGAGTTCAAATCTGTACTGCACCCTGGAGGT GGATTCCTTTGGGTATTTTGTGAATAAAGCAAAGACGCGCGTCTACAGGGACACAGCTGAGCCAAACTGGAACGAGGAATTTGAGATAGAGCTGGAGGGC TCCCAGACCCTGAGGATACTGTGCTATGAAAAGTGTTACAACAAGACGAAGATCCCCAAGGAGGACGGCGAGAGCACGGACAGACTCATGGGGAAGGGCC AGGTCCAGCTGGACCCGCAGGCCCTGCAGGACAGAGACTGGCAGCGCACCGTCATCGCCATGAATGGGATCGAAGTAAAGCTCTCGGTCAAGTTCAACAG CAGGGAGTTCAGCTTGAAGAGGATGCCGTCCCGAAAACAGACAGGGGTCTTCGGAGTCAAGATTGCTGTGGTCACCAAGAGAGAGAGGTCCAAGGTGCCC TACATCGTGCGCCAGTGCGTGGAGGAGATCGAGCGCCGAGGCATGGAGGAGGTGGGCATCTACCGCGTGTCCGGTGTGGCCACGGACATCCAGGCACTGA AGGCAGCCTTCGACGTCAATAACAAGGACGTGTCGGTGATGATGAGCGAGATGGACGTGAACGCCATCGCAGGCACGCTGAAGCTGTACTTCCGTGAGCT GCCCGAGCCCCTCTTCACTGACGAGTTCTACCCCAACTTCGCAGAGGGCATCGCTCTTTCAGACCCGGTTGCAAAGGAGAGCTGCATGCTCAACCTGCTG CTGTCCCTGCCGGAGGCCAACCTGCTCACCTTCCTTTTCCTTCTGGACCACCTGAAAAGGGTGGCAGAGAAGGAGGCAGTCAATAAGATGTCCCTGCACA ACCTCGCCACGGTCTTTGGCCCCACGCTGCTCCGGCCCTCCGAGAAGGAGAGCAAGCTCCCTGCCAACCCCAGCCAGCCTATCACCATGACTGACAGCTG GTCCTTGGAGGTCATGTCCCAGGTCCAGGTGCTGCTGTACTTCCTGCAGCTGGAGGCCATCCCTGCCCCGGACAGCAAGAGACAGAGCATCCTGTTCTCC ACCGAAGTCTAAAGGTCCCAGTCCATCTCCTGGAGGCGGACAGATGGCCTGGAAACCTCTGGCTAATCGGGCCATCCGTAGAGCGGGAACCTTCCTGAGG TGTCCTTGGGCCACCCCCAAGTGTTGGGCCATCTGCCAAGAGACAGCGACCCAAAGCCGAAGGACAGGTGGCCTGGAAAGATCCCGCCCAGGTCTGGGAG CCCCAGGCTGGCCTCAGACTGTGGTTTTTTATGTGGCCACCTGAGGGCGCCCCAAGCCAGTTCATCTCGGAGTCCAGGCCTGGCCCTGGGAGACAGGGTG AAGGGAGTGGTTTTTATGAACTTAACTTAGAGTCTAAAAGATTTCTACTGGATCACTTGTCAAGATGCGCCCTCTCTGGGGAGAAGGGAACGTGACTGGA TTCCCTCACTGTTGTATCTTGAATAAACGCTGCTGCTTCATCCTGTGGGGGCCGTGGCCCTGTCCCTGTGTGGGTGGGGCCTCTTCCATTTCCCTGACTT AGAAACCACACTCCACTTCTAACAGGGTTTGAGAGGCTTAGTCAGCACTGGGTAGCGTTTTGACTCCATTCTTGGCTTTCTTTTTCTTTCCAGAAGGATT TTTGTGCAGAAATGGGTCTTTTGTTGCCATGTTAGTCCTCCTTGGAAGGCAGCTCAGAAGGCCTGTGAAATGTCAGGGGACAGGACCCCCAGGGAGGGAA CCCCAGGCTACGCACTTTAGGGTTCGTTCTCCAGGGAGAGCGACCTCGTCCCCCGATCCTGACCGCCCTTCCGGCCCACGCTCTCCTGTTTGGCTTCCAC AGGCCTGGACTTCTCTGGCTTCTCTGCCCACACACTCCCTGCCCCCAGTGTCCCTGCCCCTGCCCCAGCACAGGTGACTTCATTTCTGTCCTCTCAGCTC AGTGGACTCGCTCAACTTTTGTATAAGTCTCCACTTGGTGGCAGCAGCTTGCTGATGACTTGTTTTAAAACTTTCATCCTAAATAACCTTTTGATACTTG AATATTTGTAAGTTTTATACATAGTTTCTAATTTTTTTCCGAACAGATCCAGATACCTAATAAGATGCTGGAATGTAATCCCTGGACAATCCGTGTCCTG GCAGCATTTGGTCTTCCTCTAAGCGCCTGGCTCCGCTGTTCTCAGGAGTGGGTTCTGAAGTCTCTGGAGAACAGGATACGTGGAGGGTTAGGAAGGGGCC AGGCCTAGAGACGGGAGACTCCCTCCCGGAGCAGGTGGAGGCACAGGACCATTCGCTACCCCATCTGCCGACACCTGCGGGGGAGCCCAGGCATTCTTTG TAAACCCTCCTGACCACCTGGCTCAAAGAAAACAGAAGCATGGAGACCGCCAAGTATTTTCAAGAAATAACCCCATGAATATTCCATCACTTTTTTAGAA AGAGGGGCTTGGGGCAGGCAGAGGAGAGAAGGGAGAGCAAACTGAGAGCCAAGTTTCCACACGGTCCTGCAGGAGGAGAGGATGCAGCTGCCCAGAGGGA AGCAGGATCACATTTAAGGAAGTGTGTGGGGTCCCTGGATGACACCAGCACCCAGTGCGGCTCTGTCTGGCACCCGCTCCCAAGGTGGGAGGAGTGGGTG TCCCCTGTGTGTCAGTGGGCAGCTCCTGCTGAACCCGCAGCTCACTAGGGAGCCTGACAGTGGGGCCATGCGCCTGACACTCCTCTCTGCTTGTGGACCT GGCAAGGCAGGGAGCAGAAAACAGCCACTTGAAGGCTTTCTGTCTGCGTCTGTGTGCAGTGTGGATTTAGTTGTGCTTTTTTCTTGCTGGGAGAGCACAG CCACCATTTACAAGCAGTGTCACCGTCGTGGGTGGCGAGGACAGAACAGGAGCCTCTGCTCTCTGTACCTATCTGGGCCCGGTGGGCTCCCTTGTCCTGG CTTCCATCTCTGTCTCAGCGACCATTCAGCCCTGCGCAGGAACACGTGTTGCTTAGAAAAGCCAAATCCAGCCTTGTCTCTGCCTCCTCTGGTCTCATGA TGTGCATCTGTTACCTTGAAACTGGAAACCAGTCTATCAATGTCTGTGCCAATTTTTTATTCCCTCCCCAACCTCCTTCCCCATACGACTTTTTATTTAT GTAGGATGTGTGCTGTCTAATGATGGGATGACCACACTTTTCCATGTTCTAAAAGTGCTCCTCTCCCGCAGGGTCCCAGGGCTGGTGGTTGCTTTGGGTC TACAGCTACGTCTTACCCACCTCCTGCCTCAACAGCCTGTGTGGTGGCAAAGCCGGTGTGGGGCTGGGGAACGCAGCGTTCTCCAGGAGGGGGACCTGGC TCTCCTTCTGCAATGCAGGCGAAGGCCTAGATGCCAGTGTGACCTCCCACAAGGCGTGGCTTCCAGACTCCCCGGCCGGAAGTGATGCTTTTTTGCCTTG GGCCCTGGGTTTGAAGCAGCCTGGCTTTCTCTTGGTAAGTGGCTGGTGTCTTAGCAGCTGCAATCTGAGCTCAGCCACCTACACACCACCGTGGCCGACA CTTTCATTAAAAAGTTTCCTGAGACGA

refseq_BCR.F1 (forward primer)
refseq_BCR.R1 (reverse primer)
Single exon skipping

Frame 0

GGRVAARWGSRLQGAPPPCAHGAAPLRGPPGSV IRAAATSPRPSPSCGAECGPGGSAARAGWLSLAS EEAAAAAAARRRRGCGAVRKREARSARAVARVW RRPGGAESSARASPCGGAPHTIAARAARALPPG APRPARRAPRSASPATREWAGIVRRRRRRAGHGG RPAPGAGLARRRAAAETGPARSPAAQVRPAAPW WTRWASRRRGRRSSRTQSPRAWSCAQWATSSRS WSAARPPFGAWSRR*TRSASA*STCRRCWPRKRR AMTGSDGASGARRRPPTAPPSPERPRRARSQRP PTEPTRRPPRSPRPGPTARVLRVRPGPGPPAGP GQPRRGNGTTGDPPPAWRRSGPTSSGSARAMASP GRTPRSPST*TSSFTTSAAW*RSTTKRCRTASA PWAARPCRWSAKSPSTARARAWGMHPGPLTGDA PRRAAAASTATTRTPS*TPAS*RTT*STPMAVAG PLGRPWSTSPTRASTSGA*WKGRARARSCAARA PLSRRSALPGPAGPTPPGVLRIAEAAIPRTAAP MRTSPPARRTSPLASPAACPQAPPPTACSGTKAA LPRRTRNSPSTAAVPPRRSAISGTGTARLSCPR PPSWASARPGRSGPTMARAPSMETQMARSEHHL DTAALQTGQRSSAGTKMGCPTLMTRPPHRPTSAA RAGAAGMRWSREPWSPLKRVSWTWKRAWR*ENG SCRESWLARRLT*ATWRHCCCP*SL*KPLPPPL SRC*RVSRSRPSSSKCLSSTRSTRSSMMGSSPAC SSGATSSGWATSSRSWPASWVCTGPSWTTTELP WKWLRSAVRPMLSLQKSPRT*EPEATKMPRIQR PRTLWKLCSTSLWTV*RGARWSSMTC*STLLPAT LTTPCCRTPSASHRTSCPASMRRSHPDGSP*R* RRESTGSC*RTASWWSWWRGPASCATSSCSPTC FSAPSSRSRAEAKRSSMTANGTFRSRISASRWWM NWRQCPTSPWCPMRSWTL*RSRSPRSRMTSRER RGRTRAARLRRG*RRSCRSRSHCCCLCLPAWPS GCTAATARVTRS*SPLTMSVQSGGRTSGSSRRSV SEASP*HPWSCRC*PTRV*NSRLSTAFR*PSIR KMMSLRGSMGF*MSSSTQPLDLSRVQICTAPWR WIPLGIL*IKQRRASTGTQLSQTGTRNLR*SWRA PRP*GYCAMKSVTTRRRSPRRTARARTDSWGRA RSSWTRRPCRTETGSAPSSP*MGSK*SSRSSST AGSSA*RGCRPENRQGSSESRLLWSPRERGPRCP TSCASAWRRSSAEAWRRWASTACPVWPRTSRH* RQPSTSITRTCR***ARWT*TPSQAR*SCTSVS CPSPSSLTSSTPTSQRASLFQTRLQRRAACSTCC CPCRRPTCSPSFSFWTT*KGWQRRRQSIRCPCT TSPRSLAPRCSGPPRRRASSLPTPASLSP*LTA GPWRSCPRSRCCCTSCSWRPSLPRTARDRASCSP PKSKGPSPSPGGGQMAWKPLANRAIRRAGTFLR CPWATPKCWAICQETATQSRRTGGLERSRPGLG APGWPQTVVFYVAT*GRPKPVHLGVQAWPWETG* REWFL*T*LRV*KISTGSLVKMRPLWGEGNVTG FPHCCILNKRCCFILWGPWPCPCVGGASSISLT *KPHSTSNRV*EA*SALGSVLTPFLAFFFFPEGF LCRNGSFVAMLVLLGRQLRRPVKCQGTGPPGRE PQATHFRVRSPGRATSSPDPDRPSGPRSPVWLP QAWTSLASLPTHSLPPVSLPLPQHR*LHFCPLSS VDSLNFCISLHLVAAAC**LVLKLSS*ITF*YL NICKFYT*FLIFFRTDPDT**DAGM*SLDNPCP GSIWSSSKRLAPLFSGVGSEVSGEQDTWRVRKGP GLETGDSLPEQVEAQDHSLPHLPTPAGEPRHSL *TLLTTWLKENRSMETAKYFQEITP*IFHHFFR KRGLGQAEERRESKLRAKFPHGPAGGEDAAAQRE AGSHLRKCVGSLDDTSTQCGSVWHPLPRWEEWV SPVCQWAAPAEPAAH*GA*QWGHAPDTPLCLWT WQGREQKTAT*RLSVCVCVQCGFSCAFFLLGEHS HHLQAVSPSWVARTEQEPLLSVPIWARWAPLSW LPSLSQRPFSPAQEHVLLRKAKSSLVSASSGLM MCICYLETGNQSINVCANFLFPPQPPSPYDFLFM *DVCCLMMG*PHFSMF*KCSSPAGSQGWWLLWV YSYVLPTSCLNSLCGGKAGVGLGNAAFSRRGTW LSFCNAGEGLDASVTSHKAWLPDSPAGSDAFLPW ALGLKQPGFLLVSGWCLSSCNLSSATYTPPWPT LSLKSFLRR

Frame 1

GGGWRLDGGAASRGPPRPVPTARPL*EARLAPS SAPRPPPPGPPLPAAQSAGRAGVRREPAG*A*R PRRRRRRRRHGGGGAVGRCGSERRGARGPWPESG GGLAERRAAPAPRRAEEPRTQ*RRAQPAPFPPA RPAPRAERPAPPHLPPGSGRALFAAAAAARAMG AARRPGPGWRGAAPPLRRAPRAARRRR*GRPRHG GPGGLRGGVEGAVPGLRAPAHGAALSGRHRAGA GALQGLHSAPGAGGEPGALPHDLPADVAGQGKE EL*PAAMGLPARGAGPRRRLRAPSVRVAPAASAR RRSRPAARRGARGPARRRGFSG*GQARDRPQAR GSRVGGTGRPGTPRQRGGAQVQLRADPQGPWPA RGGRREALLRERRVSPRARPGEGQRQRGVGPHQL PGQPGHADGAQKVPARRGLERGGCIQAPLPGTL LGEQLRRRRRLRGRRVEPPLPEGQPDRRQWR*Q APLAAPGVPALPEHLRRGHDGRGGQGPAPAQPEH L*AGEAPYLAPQVLLPPEF*GLRRRLYPGLQLQ *EPHLQRGGLLLWPVQPRVPKPHHLPHVPGQKP LSLAELATVLRQQQSPHAAVP*AAPALPGCRVRG HHRGRPQDRADLAQRWRGRLPWRRRWLVRNTTW IRLRCRPGRGAAPAPRWAALH**LALLIAPPQQ QGQGQPGCAGLGSPGVH*SE*AGLGKGLGDEKMG PVGNPG*RGDLPEPPGGTAAAHEAFESRCHHLS AGADESADRDHLLQSA*ALRDPQGVL*WALPPR AAVEPPAAGGRPLPEAGQPAGCVPGLRGQLRSCH GNG*EVLSGQCSVCRNLREPESQKQQRCQGSND QELSGNSALQACGPCDEEHAGPP*LAEAHSCQP P*PPLAAGRPPHLTELPVQHQ*GDHTPTAVHDGE EGRAPAAAEGQLHGGAGGGGPQAAPRLPVHRPA SLHQAQEAERRQNAAV*LQMVHSAHGSQLPDGG *TGGSAQHPPGAR*GAGRFEDQDLPDQE*HPERE EGEQGQQGYGEAEEEAVGAGVTAAAYVSQHGLQ GAQPQRQELHVPDLL*L*ACRVEGEHPGAAEEV FQKLLPDIRGAADADQLVCETPDCPQHSADHQ*G R**VSGALWVSECHRPLSHWI*AEFKSVLHPGG GFLWVFCE*SKDARLQGHS*AKLERGI*DRAGG LPDPEDTVL*KVLQQDEDPQGGRREHGQTHGEGP GPAGPAGPAGQRLAAHRHRHEWDRSKALGQVQQ QGVQLEEDAVPKTDRGLRSQDCCGHQEREVQGA LHRAPVRGGDRAPRHGGGGHLPRVRCGHGHPGTE GSLRRQ*QGRVGDDERDGRERHRRHAEAVLP*A ARAPLH*RVLPQLRRGHRSFRPGCKGELHAQPA AVPAGGQPAHLPFPSGPPEKGGREGGSQ*DVPAQ PRHGLWPHAAPALREGEQAPCQPQPAYHHD*QL VLGGHVPGPGAAVLPAAGGHPCPGQQETEHPVL HRSLKVPVHLLEADRWPGNLWLIGPSVEREPS*G VLGPPPSVGPSAKRQRPKAEGQVAWKDPAQVWE PQAGLRLWFFMWPPEGAPSQFISESRPGPGRQG EGSGFYELNLESKRFLLDHLSRCALSGEKGT*LD SLTVVS*INAAASSCGGRGPVPVWVGPLPFP*L RNHTPLLTGFERLSQHWVAF*LHSWLSFSFQKD FCAEMGLLLPC*SSLEGSSEGL*NVRGQDPQGGN PRLRTLGFVLQGERPRPPILTALPAHALLFGFH RPGLLWLLCPHTPCPQCPCPCPSTGDFISVLSA QWTRSTFV*VSTWWQQLADDLF*NFHPK*PFDT* IFVSFIHSF*FFSEQIQIPNKMLECNPWTIRVL AAFGLPLSAWLRCSQEWVLKSLENRIRGGLGRG QA*RRETPSRSRWRHRTIRYPICRHLRGSPGILC KPS*PPGSKKTEAWRPPSIFKK*PHEYSITFLE RGAWGRQRREGRAN*EPSFHTVLQEERMQLPRG KQDHI*GSVWGPWMTPAPSAALSGTRSQGGRSGC PLCVSGQLLLNPQLTREPDSGAMRLTLLSACGP GKAGSRKQPLEGFLSASVCSVDLVVLFSCWEST ATIYKQCHRRGWRGQNRSLCSLYLSGPGGLPCPG FHLCLSDHSALRRNTCCLEKPNPALSLPPLVS* CASVTLKLETSLSMSVPIFYSLPNLLPHTTFYL CRMCAV**WDDHTFPCSKSAPLPQGPRAGGCFGS TATSYPPPASTACVVAKPVWGWGTQRSPGGGPG SPSAMQAKA*MPV*PPTRRGFQTPRPEVMLFCL GPWV*SSLAFSW*VAGVLAAAI*AQPPTHHRGRH FH*KVS*D

Frame 2

GEGGGSMGEPPPGGPPALCPRRGPFKRPAWLRH PRRGHLPPALPFLRRRVRAGRECGESRLAELSV RGGGGGGGGTAAAGLWGGAEARGEERAGRGQSL AAAWRSGEQRPRLAVRRSPAHNSGARSPRPSPRR APPRAPSAPLRLTCHQGVGGHCSPPPPPRGPWG PPGARGRAGEAPRRR*DGPRAQPGGAGKAGRAM VDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQEL ERCKASIRRLEQEVNQERFRMIYLQTLLAKEKK SYDRQRWGFRRAAQAPDGASEPRASASRPQPAP ADGADPPPAEEPEARPDGEGSPGKARPGTARRPG AAASGERDDRGPPASVAALRSNFERIRKGHGQP GADAEKPFYVNVEFHHERGLVKVNDKEVSDRIS SLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRS SESSCGVDGDYEDAELNPRFLKDNLIDANGGSR PPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQS TSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSN ENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSR SPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSE ATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPG YGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSS KGRGSRDALVSGALESTKASELDLEKGLEMRKW VLSGILASEETYLSHLEALLLPMKPLKAAATTSQ PVLTSQQIETIFFKVPELYEIHKEFYDGLFPRV QQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVA MEMAEKCCQANAQFAEISENLRARSNKDAKDPTT KNSLETLLYKPVDRVTRSTLVLHDLLKHTPASH PDHPLLQDALRISQNFLSSINEEITPRRQSMTV KKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLL LCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVD ELEAVPNIPLVPDEELDALKIKISQIKNDIQRE KRANKGSKATERLKKKLSEQESLLLLMSPSMAFR VHSRNGKSYTFLISSDYERAEWRENIREQQKKC FRSFSLTSVELQMLTNSCVKLQTVHSIPLTINK EDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEV DSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEG SQTLRILCYEKCYNKTKIPKEDGESTDRLMGKG QVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNS REFSLKRMPSRKQTGVFGVKIAVVTKRERSKVP YIVRQCVEEIERRGMEEVGIYRVSGVATDIQAL KAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFREL PEPLFTDEFYPNFAEGIALSDPVAKESCMLNLL LSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLH NLATVFGPTLLRPSEKESKLPANPSQPITMTDSW SLEVMSQVQVLLYFLQLEAIPAPDSKRQSILFS TEV*RSQSISWRRTDGLETSG*SGHP*SGNLPE VSLGHPQVLGHLPRDSDPKPKDRWPGKIPPRSGS PRLASDCGFLCGHLRAPQASSSRSPGLALGDRV KGVVFMNLT*SLKDFYWITCQDAPSLGRRERDW IPSLLYLE*TLLLHPVGAVALSLCGWGLFHFPDL ETTLHF*QGLRGLVSTG*RFDSILGFLFLSRRI FVQKWVFCCHVSPPWKAAQKACEMSGDRTPREG TPGYAL*GSFSRESDLVPRS*PPFRPTLSCLAST GLDFSGFSAHTLPAPSVPAPAPAQVTSFLSSQL SGLAQLLYKSPLGGSSLLMTCFKTFILNNLLIL EYL*VLYIVSNFFPNRSRYLIRCWNVIPGQSVSW QHLVFL*APGSAVLRSGF*SLWRTGYVEG*EGA RPRDGRLPPGAGGGTGPFATPSADTCGGAQAFF VNPPDHLAQRKQKHGDRQVFSRNNPMNIPSLF*K EGLGAGRGEKGEQTESQVSTRSCRRRGCSCPEG SRITFKEVCGVPG*HQHPVRLCLAPAPKVGGVG VPCVSVGSSC*TRSSLGSLTVGPCA*HSSLLVDL ARQGAENSHLKAFCLRLCAVWI*LCFFLAGRAQ PPFTSSVTVVGGEDRTGASALCTYLGPVGSLVL ASISVSATIQPCAGTRVA*KSQIQPCLCLLWSHD VHLLP*NWKPVYQCLCQFFIPSPTSFPIRLFIY VGCVLSNDGMTTLFHVLKVLLSRRVPGLVVALG LQLRLTHLLPQQPVWWQSRCGAGERSVLQEGDLA LLLQCRRRPRCQCDLPQGVASRLPGRK*CFFAL GPGFEAAWLSLGKWLVS*QLQSELSHLHTTVAD TFIKKFPET