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Sequences

Sequence NM_031362

GGGAGGGACGAACCGCGCGACCGAGCCCTACAAAACCCGCCCCGGCCGAGTGGCGAGGCGAGCTTTCCAGCCGGGCTCCCAGAGCCGCGCTGCGCAGGAG ACGCGGTGGCCTGAGAGCCTGAGGGTCCCCGGACTCGCCCAGGCTCTGAGCGCGCGCCCACCATGAGCGCCCGGACCGCCCCCAGGCCGCAGGTGCTCCT GCTGCCGCTCCTGCTGGTGCTCCTGGCGGCGGCGCCCGCAGCCAGCAAGGGTTGTGTCTGTAAAGACAAAGGCCAGTGCTTCTGTGACGGGGCCAAAGGG GAGAAGGGGGAGAAGGGCTTTCCTGGACCCCCCGGTTCTCCTGGCCAGAAAGGATTCACAGGTCCTGAAGGCTTGCCTGGACCGCAGGGACCCAAGGGCT TTCCAGGACTTCCAGGACTCACGGGTTCCAAAGGTGTAAGGGGAATAAGTGGATTGCCAGGATTTTCTGGTTCTCCTGGACTTCCAGGCACCCCAGGCAA TACCGGGCCTTACGGACTTGTCGGTGTACCAGGATGCAGTGGTTCTAAGGGTGAGCAGGGGTTTCCAGGACTCCCAGGGACACTGGGCTACCCAGGGATC CCGGGTGCTGCTGGTTTGAAAGGACAAAAGGGTGCTCCTGCTAAAGAAGAAGATATAGAACTTGATGCAAAAGGCGACCCCGGGTTGCCAGGGGCTCCAG GACCCCAGGGTTTGCCAGGCCCTCCAGGTTTTCCTGGGCCTGTTGGCCCACCTGGTCCTCCGGGATTCTTTGGCTTTCCAGGAGCCATGGGACCTAGAGG ACCTAAGGGTCACATGGGTGAAAGAGTGATAGGACATAAAGGAGAGCGGGGTGTGAAAGGGTTAACAGGACCCCCGGGACCACCAGGAACAGTTATTGTG ACCCTAACTGGCCCAGATAACAGAACGGACCTCAAGGGGGAAAAGGGAGACAAGGGAGCAATGGGCGAGCCTGGACCTCCTGGACCCTCAGGACTGCCTG GAGAATCATATGGATCTGAAAAGGGTGCTCCTGGAGACCCTGGCCTGCAGGGAAAACCCGGAAAAGATGGTGTTCCTGGCTTCCCTGGAAGTGAGGGAGT CAAGGGCAACAGGGGTTTCCCTGGGTTAATGGGTGAAGATGGCATTAAGGGACAGAAAGGGGACATTGGCCCTCCAGGATTTCGTGGTCCAACAGAATAT TATGACACATACCAGGAAAAGGGAGATGAAGGCACTCCAGGCCCACCAGGGCCCAGAGGAGCTCGTGGCCCACAAGGTCCCAGTGGTCCCCCCGGAGTTC CTGGAAGTCCTGGATCATCAAGGCCTGGCCTCAGAGGAGCCCCTGGATGGCCAGGCCTGAAAGGAAGTAAAGGGGAACGAGGCCGCCCAGGAAAGGATGC CATGGGGACTCCTGGGTCCCCAGGTTGTGCTGGTTCACCAGGTCTTCCAGGATCACCGGGACCTCCAGGACCGCCAGGTGACATCGTTTTTCGCAAGGGT CCACCTGGAGATCACGGACTGCCAGGCTATCTAGGGTCTCCAGGAATCCCAGGAGTTGATGGGCCCAAAGGAGAACCAGGCCTCCTGTGTACACAGTGCC CTTATATCCCAGGGCCTCCCGGTCTCCCAGGATTGCCAGGGTTACATGGTGTAAAAGGAATCCCAGGAAGACAAGGCGCAGCTGGCTTGAAAGGAAGCCC AGGGTCCCCAGGAAATACAGGTCTTCCAGGATTTCCAGGTTTCCCAGGTGCCCAGGGTGACCCAGGACTTAAAGGAGAAAAAGGTGAAACACTTCAGCCT GAGGGGCAAGTGGGTGTCCCAGGTGACCCGGGGCTCAGAGGCCAACCTGGGAGAAAGGGCTTGGATGGAATTCCTGGAACTCCGGGAGTGAAAGGATTAC CAGGACCTAAAGGCGAACTGGCTCTGAGTGGTGAGAAAGGGGACCAAGGTCCTCCAGGGGATCCTGGCTCCCCTGGGTCCCCAGGACCTGCAGGACCAGC TGGACCACCTGGCTACGGACCCCAAGGAGAACCTGGTCTCCAGGGCACGCAAGGAGTTCCTGGAGCCCCCGGACCACCCGGAGAAGCCGGCCCTAGGGGA GAGCTCAGTGTTTCAACACCAGTTCCAGGCCCACCAGGACCTCCAGGGCCCCCTGGCCATCCTGGCCCCCAAGGTCCACCTGGTATCCCTGGATCCCTGG GGAAATGTGGAGATCCTGGTCTTCCAGGGCCTGATGGTGAACCAGGAATTCCAGGAATTGGATTTCCTGGGCCTCCTGGACCTAAGGGAGACCAAGGTTT TCCAGGTACAAAAGGATCACTGGGTTGTCCTGGAAAAATGGGAGAGCCTGGGTTACCTGGAAAGCCAGGCCTCCCAGGAGCCAAGGGAGAACCAGCAGTA GCCATGCCTGGAGGACCAGGAACACCAGGTTTTCCAGGAGAAAGAGGCAATTCTGGGGAACATGGAGAAATTGGACTCCCTGGACTTCCAGGTCTCCCTG GAACTCCAGGAAATGAAGGGCTTGATGGACCACGAGGAGATCCAGGGCAGCCTGGACCACCTGGAGAACAAGGACCCCCAGGAAGGTGCATAGAGGGTCC CAGGGGAGCCCAAGGACTTCCAGGCTTAAATGGATTGAAAGGGCAACAAGGCAGAAGAGGTAAAACGGGGCCAAAGGGAGACCCAGGAATTCCAGGCTTG GATAGATCAGGATTTCCTGGAGAAACTGGATCACCAGGAATTCCAGGTCATCAAGGTGAAATGGGACCACTGGGTCAAAGAGGATATCCAGGAAATCCGG GAATTTTAGGGCCACCAGGTGAAGATGGAGTGATTGGGATGATGGGCTTTCCTGGAGCCATTGGCCCTCCAGGGCCCCCTGGGAACCCAGGCACACCAGG GCAGAGGGGGAGCCCTGGAATTCCAGGAGTAAAGGGCCAGAGAGGAACCCCAGGAGCCAAGGGGGAACAAGGAGATAAAGGAAATCCCGGGCCTTCAGAG ATATCCCACGTAATAGGGGACAAAGGAGAACCAGGTCTCAAAGGATTCGCAGGAAATCCAGGTGAGAAAGGAAACAGAGGCGTTCCAGGGATGCCAGGTT TAAAGGGCCTCAAAGGACTACCCGGACCAGCAGGACCACCAGGCCCCAGAGGAGATTTGGGCAGCACTGGGAATCCTGGAGAACCAGGACTGCGTGGTAT ACCAGGAAGCATGGGGAACATGGGCATGCCAGGTTCTAAAGGAAAAAGGGGAACTTTGGGATTCCCAGGTCGAGCAGGAAGACCAGGCCTCCCAGGTATT CATGGTCTCCAGGGAGATAAGGGAGAGCCAGGTTATTCAGAAGGTACAAGGCCAGGACCACCGGGACCAACGGGGGATCCAGGACTGCCGGGTGATATGG GAAAGAAAGGAGAAATGGGGCAACCTGGCCCACCTGGACATTTGGGGCCTGCTGGACCTGAGGGAGCCCCTGGAAGTCCTGGAAGTCCTGGCCTCCCAGG AAAGCCAGGTCCTCATGGTGATTTGGGTTTTAAAGGAATCAAAGGCCTCCTGGGCCCTCCAGGAATCAGAGGCCCTCCAGGTCTTCCAGGATTTCCAGGA TCTCCTGGACCAATGGGTATAAGAGGTGACCAAGGACGTGATGGAATTCCTGGTCCAGCCGGAGAAAAGGGAGAAACGGGTTTATTGAGGGCCCCTCCAG GCCCAAGAGGGAACCCTGGTGCTCAAGGAGCCAAAGGAGACAGGGGAGCCCCAGGTTTTCCTGGCCTCCCGGGCAGAAAAGGGGCCATGGGAGATGCTGG ACCTCGAGGACCCACAGGCATAGAAGGATTCCCAGGGCCACCAGGTCTGCCCGGTGCAATTATCCCTGGCCAGACAGGAAATCGTGGTCCACCAGGCTCA AGAGGAAGCCCAGGTGCGCCTGGTCCCCCTGGACCTCCAGGGAGTCATGTAATAGGCATAAAAGGAGACAAAGGGTCTATGGGCCACCCTGGCCCAAAAG GTCCACCTGGAACTGCAGGAGACATGGGACCACCAGGTCGTCTGGGAGCACCAGGTACTCCAGGTCTTCCAGGACCCAGAGGTGATCCTGGATTCCAGGG GTTTCCAGGCGTGAAAGGAGAAAAGGGTAATCCTGGATTTCTAGGATCCATTGGACCTCCAGGACCAATTGGGCCAAAAGGACCACCTGGTGTACGTGGA GACCCTGGCACACTTAAGATTATCTCCCTTCCAGGAAGCCCAGGGCCACCTGGCACACCTGGAGAACCAGGGATGCAGGGAGAACCTGGGCCACCAGGGC CACCTGGAAACCTAGGACCCTGTGGGCCAAGAGGTAAGCCAGGCAAGGATGGAAAACCAGGAACTCCTGGACCAGCTGGAGAAAAAGGCAACAAAGGTTC TAAAGGAGAGCCAGGACCAGCTGGATCAGATGGATTGCCAGGTTTGAAAGGAAAACGTGGAGACAGTGGATCACCTGCAACCTGGACAACGAGAGGCTTT GTCTTCACCCGACACAGTCAAACCACAGCAATTCCTTCATGTCCAGAGGGGACAGTGCCACTCTACAGTGGGTTTTCTTTTCTTTTTGTACAAGGAAATC AACGAGCCCACGGACAAGACCTTGGAACTCTTGGCAGCTGCCTGCAGCGATTTACCACAATGCCATTCTTATTCTGCAATGTCAATGATGTATGTAATTT TGCATCTCGAAATGATTATTCATACTGGCTGTCAACACCAGCTCTGATGCCAATGAACATGGCTCCCATTACTGGCAGAGCCCTTGAGCCTTATATAAGC AGATGCACTGTTTGTGAAGGTCCTGCGATCGCCATAGCCGTTCACAGCCAAACCACTGACATTCCTCCATGTCCTCACGGCTGGATTTCTCTCTGGAAAG GATTTTCATTCATCATGAAAGCCTATTCCATCAACTGTGAAAGCTGGGGAATTAGAAAAAATAATAAGTCGCTGTCAGGTGTGCATGAAGAAAAGACACT GAAGCTAAAAAAGACAGCAGAACTGCTATTTTTCATCCTAAAGAACAAAGTAATGACAGAACATGCTGTTATTTAGGTATTTTTCTTTAACCAAACAATA TTGCTCCATGATGACTTAGTACAAAGTTTCAATTTGTTTCCCCACAAAACAAAGCAATTCTTTCAAGTCAGTTCTGTGATCTGGGTCTCTAATCTGTGCT GTTTCAAAGTTCTCTGTGGCAAAGCAGCAACTATTCACAAAATATCACCAAAAACCTATTCCACTTACATCCAAGGCACTGTCACTACGGTGATTGTATG AAGTTTGAATGCTGCAAGTTATGAAATATTTGGCCCGCTGGATTCCCACATTTGTCTTCTTTCTGTCTTTAAGACTCAGGGAGGCTAAATCAGTGTTTGA TTGCCCCGCCAACCCTTCCTGAAACTTCAGACCCTGGGTAGGGGAAGAGAAGGGGGCATGTGGTATCCTGGAGCATTGTGTATAGAACTGGATTTTCAGA CCTGCTGAGGACCGTAAGGCCTGATGGAACACAGAACTGAACTGAGGTTCATGGATTTTCCAGGACTGTTTCAAACATGCCCATTACTAACGGCAAAAGG GGGATTCCCTGATGGAACCATAATACCCTTGGAAATACTGTATGGTTTTGTTTTGTTTTGTTGGTTTTTAAAGATTTTTGTTTGTTTATTGAATTCATTT CACTGTAGCTCTAAAATCTGCTTGTATTCCAAGCATATAAAATTTTCCCCCTTAGTGAATTAGTTTTAAAATGATATTGTTATATACATACTATGAAATA TGTATAACTTTAACTTCTGTTTTACCAGCATACCCACACAAATAACAAGAATACTACTTATGAAATGTGCACTTTATCCTCATTCCATAAATGTCGGTGC ATACCTTATGTAAGGGAGCAGTTCAATAATCCATGAAAGAACTTAAGGCATTTGTTGGTTTATCAGACTCGGAATCTATTTTCTCATTGCTCTGAATATG TCATCACTCTAGGTTTTACAGATTTATTCCTTTGTTACTTCTCTAATTCTTCCTTTGTAAAAAAAAAAAAAAGCAACACTTTTTATGTTATATGTTGTTC TTACAAACCATACTGAAAGAGTCCATTGTTTAAAAATCTTAATGTATCAAACTGTATAACTTGGCCGCTGTATGTCTTAAAACCTGCTTTTCAATGTGTT GATACATTCCCAAGGTTACTTAATTCAACTTAACTATCATCTTATTCAGCACCAAGCATGTCCCAGGCACTGTACTAACCTACAGAGATGCTAAGAGAAA AAAAAGACTTGTTTCTGATCTAATATCCCAGAAAAAGTAACTCATTGCTCTGTTAATAATCTCACATATACAAGTAGCTTCCCTCCCCTCTAGTTTTTTC TTCCTTTTCACTGCTGTTATATTTCATCATGATAATTCAGCAGGCCCAAGTAAAGGTTAAAAATAAGGTCTATGCCTAGGGAAACTCAGGGCTTCTAGTT TCTCTTAGAAAAGCTAAGAGAAGATAAGGTCTGAATAATAGCAGAAAAACCAACATCTACAAAACATTAAACTAGTGTTATACTTGATGATAACACTATT TGATGAGTCTTAGAGTCCAGACACAAAGAGACAAAGCTTTGAAGATGCTTTTTGATCTACCTAGGTGGAGTTGGTGGTGCTGATATTTAAATTCAGGCTA CTGCTTCAATCTCAATTGCTTTGTAAGTGAAAAACATGACCCAGAGGACAGCACAGACTATGGCCATGGCTCACATGGTTTACATCCTTCACTGCTCACG TGTTTGCTGTCAAGCCATTTTTACATCTAAACTAAGATGTGCAGCATTTCACTTATTTAGATTCACTTAACAAACAAATTTTTCTGCTTTAAAAATGTCT TATTGTCCCAAGTGTACTATAGCGGCATATAGAGCTAGCTAATCTCTACAAACCCTCTGTAGGCCAGTAGTTCTCAAAGTGTGGTCTCTGGAAGAGCAGT ATCAGCATCATCTGGGAACTTGTCACAGATGCAGATTCTAGGGACCACTCCAGACCTACACAATCAGAAACTCTTGGGGGAGGGCCCGAAATATCTATGT TTTACCAAGCCCACCACATGATTCTGATGTACTCTAAATACTGAGAAAACCTGTTCTAGACAAATACCCAAGCAACAACTCCGCAGGCAGTTACCAAGTA CGGCTGGCTACAACTGCTCCATCCGTGCCTCTTTTTAAAGTTCAAACTCACAGGTGACTCTAAGGTTATCTACTTTTACTCATAAGTAAAAGCCCTAGAC TGGTGCTAATGTCAAACCACTGGCCTCCACTCAGGCCTCCATCTTCTCATGCCCTCTTACCAGTATTTAACTTCTGAGGAAGACAAGTGATGCTAAAACC TGAAATTCCAATGAAGCCATATGAACAGCTGTTCAGTTGCACTTCTAAGACTTTACTTAGCAGTAAATTATAGCTCATGTGCATTATTTTCCAGATAACT TAGCTTATGAGTAGCTTATACAATTATGAAGATTTAATATTACAGATAAAATGTAAACTGTTTCTTTAAAATTGGGGCTTCAACTTTGGAATTTCACAGC GTGCTAAAATAACAGATTTCTCAGAAGTCTTTCAGCAAGATAAACATTATTAAGTAACTTATTTATGAAAGTATTAAAATGCTTACATTTGAACTTGATG GCTAACTTACAAAGATTCTCTATGTATCAAATGTAACTTACTGCGACTAAACTTAATTTAATATTTACTCTATAACCAAATGAAATATATTTAAAATATA TTGAATATTTTATATTGTTATATCCTGACAAGATTATAATATTTTAATGTACTAATATTTCTGTAATTATATCTAAAATATTATTTTATTATATTGCCTA AGAATAAACATTTGTTAAATTGG

refseq_COL4A3.F1 (forward primer)
refseq_COL4A3.R1 (reverse primer)
Single exon skipping

Frame 0

GRDEPRDRALQNPPRPSGEASFPAGLPEPRCAG DAVA*EPEGPRTRPGSERAPTMSARTAPRPQVLL LPLLLVLLAAAPAASKGCVCKDKGQCFCDGAKG EKGEKGFPGPPGSPGQKGFTGPEGLPGPQGPKG FPGLPGLTGSKGVRGISGLPGFSGSPGLPGTPGN TGPYGLVGVPGCSGSKGEQGFPGLPGTLGYPGI PGAAGLKGQKGAPAKEEDIELDAKGDPGLPGAP GPQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPRG PKGHMGERVIGHKGERGVKGLTGPPGPPGTVIV TLTGPDNRTDLKGEKGDKGAMGEPGPPGPSGLP GESYGSEKGAPGDPGLQGKPGKDGVPGFPGSEGV KGNRGFPGLMGEDGIKGQKGDIGPPGFRGPTEY YDTYQEKGDEGTPGPPGPRGARGPQGPSGPPGV PGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDA MGTPGSPGCAGSPGLPGSPGPPGPPGDIVFRKG PPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQC PYIPGPPGLPGLPGLHGVKGIPGRQGAAGLKGSP GSPGNTGLPGFPGFPGAQGDPGLKGEKGETLQP EGQVGVPGDPGLRGQPGRKGLDGIPGTPGVKGL PGPKGELALSGEKGDQGPPGDPGSPGSPGPAGPA GPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRG ELSVSTPVPGPPGPPGPPGHPGPQGPPGIPGSL GKCGDPGLPGPDGEPGIPGIGFPGPPGPKGDQGF PGTKGSLGCPGKMGEPGLPGKPGLPGAKGEPAV AMPGGPGTPGFPGERGNSGEHGEIGLPGLPGLP GTPGNEGLDGPRGDPGQPGPPGEQGPPGRCIEGP RGAQGLPGLNGLKGQQGRRGKTGPKGDPGIPGL DRSGFPGETGSPGIPGHQGEMGPLGQRGYPGNP GILGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPG QRGSPGIPGVKGQRGTPGAKGEQGDKGNPGPSE ISHVIGDKGEPGLKGFAGNPGEKGNRGVPGMPG LKGLKGLPGPAGPPGPRGDLGSTGNPGEPGLRGI PGSMGNMGMPGSKGKRGTLGFPGRAGRPGLPGI HGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDM GKKGEMGQPGPPGHLGPAGPEGAPGSPGSPGLPG KPGPHGDLGFKGIKGLLGPPGIRGPPGLPGFPG SPGPMGIRGDQGRDGIPGPAGEKGETGLLRAPP GPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAG PRGPTGIEGFPGPPGLPGAIIPGQTGNRGPPGS RGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPK GPPGTAGDMGPPGRLGAPGTPGLPGPRGDPGFQG FPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVRG DPGTLKIISLPGSPGPPGTPGEPGMQGEPGPPG PPGNLGPCGPRGKPGKDGKPGTPGPAGEKGNKGS KGEPGPAGSDGLPGLKGKRGDSGSPATWTTRGF VFTRHSQTTAIPSCPEGTVPLYSGFSFLFVQGN QRAHGQDLGTLGSCLQRFTTMPFLFCNVNDVCNF ASRNDYSYWLSTPALMPMNMAPITGRALEPYIS RCTVCEGPAIAIAVHSQTTDIPPCPHGWISLWK GFSFIMKAYSINCESWGIRKNNKSLSGVHEEKTL KLKKTAELLFFILKNKVMTEHAVI*VFFFNQTI LLHDDLVQSFNLFPHKTKQFFQVSSVIWVSNLC CFKVLCGKAATIHKISPKTYSTYIQGTVTTVIV* SLNAASYEIFGPLDSHICLLSVFKTQGG*ISV* LPRQPFLKLQTLGRGREGGMWYPGALCIELDFQ TC*GP*GLMEHRTELRFMDFPGLFQTCPLLTAKG GFPDGTIIPLEILYGFVLFCWFLKIFVCLLNSF HCSSKICLYSKHIKFSPLVN*F*NDIVIYIL*N MYNFNFCFTSIPTQITRILLMKCALYPHSINVGA YLM*GSSSIIHERT*GICWFIRLGIYFLIALNM SSL*VLQIYSFVTSLILPL*KKKKATLFMLYVV LTNHTERVHCLKILMYQTV*LGRCMS*NLLFNVL IHSQGYLIQLNYHLIQHQACPRHCTNLQRC*EK KKTCF*SNIPEKVTHCSVNNLTYTSSFPPL*FF LPFHCCYISS**FSRPK*RLKIRSMPRETQGF*F LLEKLREDKV*IIAEKPTSTKH*TSVILDDNTI **VLESRHKETKL*RCFLIYLGGVGGADI*IQA TASISIAL*VKNMTQRTAQTMAMAHMVYILHCSR VCCQAIFTSKLRCAAFHLFRFT*QTNFSALKMS YCPKCTIAAYRAS*SLQTLCRPVVLKVWSLEEQ YQHHLGTCHRCRF*GPLQTYTIRNSWGRARNIYV LPSPPHDSDVL*ILRKPVLDKYPSNNSAGSYQV RLATTAPSVPLFKVQTHR*L*GYLLLLISKSPR LVLMSNHWPPLRPPSSHALLPVFNF*GRQVMLKP EIPMKPYEQLFSCTSKTLLSSKL*LMCIIFQIT *LMSSLYNYEDLILQIKCKLFL*NWGFNFGISQ RAKITDFSEVFQQDKHY*VTYL*KY*NAYI*T*W LTYKDSLCIKCNLLRLNLI*YLLYNQMKYI*NI LNILYCYILTRL*YFNVLIFL*LYLKYYFIILP KNKHLLNW

Frame 1

GGTNRATEPYKTRPGRVARRAFQPGSQSRAAQE TRWPESLRVPGLAQALSARPP*APGPPPGRRCS CCRSCWCSWRRRPQPARVVSVKTKASASVTGPKG RRGRRAFLDPPVLLARKDSQVLKACLDRRDPRA FQDFQDSRVPKV*GE*VDCQDFLVLLDFQAPQA IPGLTDLSVYQDAVVLRVSRGFQDSQGHWATQGS RVLLV*KDKRVLLLKKKI*NLMQKATPGCQGLQ DPRVCQALQVFLGLLAHLVLRDSLAFQEPWDLE DLRVTWVKE**DIKESGV*KG*QDPRDHQEQLL* P*LAQITERTSRGKRETREQWASLDLLDPQDCL ENHMDLKRVLLETLACRENPEKMVFLASLEVRE SRATGVSLG*WVKMALRDRKGTLALQDFVVQQNI MTHTRKREMKALQAHQGPEELVAHKVPVVPPEF LEVLDHQGLASEEPLDGQA*KEVKGNEAAQERM PWGLLGPQVVLVHQVFQDHRDLQDRQVTSFFARV HLEITDCQAI*GLQESQELMGPKENQASCVHSA LISQGLPVSQDCQGYMV*KESQEDKAQLA*KEA QGPQEIQVFQDFQVSQVPRVTQDLKEKKVKHFSL RGKWVSQVTRGSEANLGERAWMEFLELRE*KDY QDLKANWL*VVRKGTKVLQGILAPLGPQDLQDQ LDHLATDPKENLVSRARKEFLEPPDHPEKPALGE SSVFQHQFQAHQDLQGPLAILAPKVHLVSLDPW GNVEILVFQGLMVNQEFQELDFLGLLDLRETKV FQVQKDHWVVLEKWESLGYLESQASQEPRENQQ* PCLEDQEHQVFQEKEAILGNMEKLDSLDFQVSL ELQEMKGLMDHEEIQGSLDHLENKDPQEGA*RV PGEPKDFQA*MD*KGNKAEEVKRGQRETQEFQAW IDQDFLEKLDHQEFQVIKVKWDHWVKEDIQEIR EF*GHQVKME*LG*WAFLEPLALQGPLGTQAHQ GRGGALEFQE*RAREEPQEPRGNKEIKEIPGLQR YPT**GTKENQVSKDSQEIQVRKETEAFQGCQV *RASKDYPDQQDHQAPEEIWAALGILENQDCVV YQEAWGTWACQVLKEKGELWDSQVEQEDQASQVF MVSREIRESQVIQKVQGQDHRDQRGIQDCRVIW ERKEKWGNLAHLDIWGLLDLREPLEVLEVLASQ ESQVLMVIWVLKESKASWALQESEALQVFQDFQD LLDQWV*EVTKDVMEFLVQPEKREKRVY*GPLQ AQEGTLVLKEPKETGEPQVFLASRAEKGPWEML DLEDPQA*KDSQGHQVCPVQLSLARQEIVVHQAQ EEAQVRLVPLDLQGVM**A*KETKGLWATLAQK VHLELQETWDHQVVWEHQVLQVFQDPEVILDSR GFQA*KEKRVILDF*DPLDLQDQLGQKDHLVYVE TLAHLRLSPFQEAQGHLAHLENQGCRENLGHQG HLET*DPVGQEVSQARMENQELLDQLEKKATKV LKESQDQLDQMDCQV*KENVETVDHLQPGQREAL SSPDTVKPQQFLHVQRGQCHSTVGFLFFLYKEI NEPTDKTLELLAAACSDLPQCHSYSAMSMMYVI LHLEMIIHTGCQHQL*CQ*TWLPLLAEPLSLI*A DALFVKVLRSP*PFTAKPLTFLHVLTAGFLSGK DFHSS*KPIPSTVKAGELEKIISRCQVCMKKRH *S*KRQQNCYFSS*RTK**QNMLLFRYFSLTKQY CSMMT*YKVSICFPTKQSNSFKSVL*SGSLICA VSKFSVAKQQLFTKYHQKPIPLTSKALSLR*LY EV*MLQVMKYLARWIPTFVFFLSLRLREAKSVFD CPANPS*NFRPWVGEEKGACGILEHCV*NWIFR PAEDRKA*WNTELN*GSWIFQDCFKHAHY*RQK GDSLMEP*YPWKYCMVLFCFVGF*RFLFVY*IHF TVALKSACIPSI*NFPP**ISFKMILLYTYYEI CITLTSVLPAYPHK*QEYYL*NVHFILIP*MSV HTLCKGAVQ*SMKELKAFVGLSDSESIFSLL*IC HHSRFYRFIPLLLL*FFLCKKKKKQHFLCYMLF LQTILKESIV*KS*CIKLYNLAAVCLKTCFSMC *YIPKVT*FNLTIILFSTKHVPGTVLTYRDAKRK KRLVSDLISQKK*LIALLIISHIQVASLPSSFF FLFTAVIFHHDNSAGPSKG*K*GLCLGKLRASS FS*KS*EKIRSE**QKNQHLQNIKLVLYLMITLF DES*SPDTKRQSFEDAF*ST*VELVVLIFKFRL LLQSQLLCK*KT*PRGQHRLWPWLTWFTSFTAH VFAVKPFLHLN*DVQHFTYLDSLNKQIFLL*KCL IVPSVL*RHIELANLYKPSVGQ*FSKCGLWKSS ISIIWELVTDADSRDHSRPTQSETLGGGPEISM FYQAHHMILMYSKY*ENLF*TNTQATTPQAVTKY GWLQLLHPCLFLKFKLTGDSKVIYFYS*VKALD WC*CQTTGLHSGLHLLMPSYQYLTSEEDK*C*N LKFQ*SHMNSCSVALLRLYLAVNYSSCALFSR*L SL*VAYTIMKI*YYR*NVNCFFKIGASTLEFHS VLK*QISQKSFSKINIIK*LIYESIKMLTFELD G*LTKILYVSNVTYCD*T*FNIYSITK*NIFKIY *IFYIVIS*QDYNILMY*YFCNYI*NIILLYCL RINIC*I

Frame 2

EGRTARPSPTKPAPAEWRGELSSRAPRAALRRR RGGLRA*GSPDSPRL*ARAHHERPDRPQAAGAP AAAPAGAPGGGARSQQGLCL*RQRPVLL*RGQR GEGGEGLSWTPRFSWPERIHRS*RLAWTAGTQGL SRTSRTHGFQRCKGNKWIARIFWFSWTSRHPRQ YRALRTCRCTRMQWF*G*AGVSRTPRDTGLPRD PGCCWFERTKGCSC*RRRYRT*CKRRPRVARGSR TPGFARPSRFSWACWPTWSSGILWLSRSHGT*R T*GSHG*KSDRT*RRAGCERVNRTPGTTRNSYC DPNWPR*QNGPQGGKGRQGSNGRAWTSWTLRTAW RIIWI*KGCSWRPWPAGKTRKRWCSWLPWK*GS QGQQGFPWVNG*RWH*GTERGHWPSRISWSNRI L*HIPGKGR*RHSRPTRAQRSSWPTRSQWSPRSS WKSWIIKAWPQRSPWMARPERK*RGTRPPRKGC HGDSWVPRLCWFTRSSRITGTSRTAR*HRFSQG STWRSRTARLSRVSRNPRS*WAQRRTRPPVYTVP LYPRASRSPRIARVTWCKRNPRKTRRSWLERKP RVPRKYRSSRISRFPRCPG*PRT*RRKR*NTSA *GASGCPR*PGAQRPTWEKGLGWNSWNSGSERIT RT*RRTGSEW*ERGPRSSRGSWLPWVPRTCRTS WTTWLRTPRRTWSPGHARSSWSPRTTRRSRP*G RAQCFNTSSRPTRTSRAPWPSWPPRSTWYPWIPG EMWRSWSSRA*W*TRNSRNWISWASWT*GRPRF SRYKRITGLSWKNGRAWVTWKARPPRSQGRTSS SHAWRTRNTRFSRRKRQFWGTWRNWTPWTSRSPW NSRK*RA*WTTRRSRAAWTTWRTRTPRKVHRGS QGSPRTSRLKWIERATRQKR*NGAKGRPRNSRL G*IRISWRNWITRNSRSSR*NGTTGSKRISRKSG NFRATR*RWSDWDDGLSWSHWPSRAPWEPRHTR AEGEPWNSRSKGPERNPRSQGGTRR*RKSRAFR DIPRNRGQRRTRSQRIRRKSR*ERKQRRSRDARF KGPQRTTRTSRTTRPQRRFGQHWESWRTRTAWY TRKHGEHGHARF*RKKGNFGIPRSSRKTRPPRY SWSPGR*GRARLFRRYKARTTGTNGGSRTAG*YG KERRNGATWPTWTFGACWT*GSPWKSWKSWPPR KARSSW*FGF*RNQRPPGPSRNQRPSRSSRISR ISWTNGYKR*PRT*WNSWSSRRKGRNGFIEGPSR PKREPWCSRSQRRQGSPRFSWPPGQKRGHGRCW TSRTHRHRRIPRATRSARCNYPWPDRKSWSTRL KRKPRCAWSPWTSRESCNRHKRRQRVYGPPWPKR STWNCRRHGTTRSSGSTRYSRSSRTQR*SWIPG VSRRERRKG*SWISRIHWTSRTNWAKRTTWCTW RPWHT*DYLPSRKPRATWHTWRTRDAGRTWATRA TWKPRTLWAKR*ARQGWKTRNSWTSWRKRQQRF *RRARTSWIRWIARFERKTWRQWITCNLDNERL CLHPTQSNHSNSFMSRGDSATLQWVFFSFCTRKS TSPRTRPWNSWQLPAAIYHNAILILQCQ*CM*F CISK*LFILAVNTSSDANEHGSHYWQSP*ALYK QMHCL*RSCDRHSRSQPNH*HSSMSSRLDFSLER IFIHHESLFHQL*KLGN*KK**VAVRCA*RKDT EAKKDSRTAIFHPKEQSNDRTCCYLGIFL*PNN IAP**LSTKFQFVSPQNKAILSSQFCDLGL*SVL FQSSLWQSSNYSQNITKNLFHLHPRHCHYGDCM KFECCKL*NIWPAGFPHLSSFCL*DSGRLNQCL IAPPTLPETSDPG*GKRRGHVVSWSIVYRTGFSD LLRTVRPDGTQN*TEVHGFSRTVSNMPITNGKR GIP*WNHNTLGNTVWFCFVLLVFKDFCLFIEFI SL*L*NLLVFQAYKIFPLSELVLK*YCYIHTMKY V*L*LLFYQHTHTNNKNTTYEMCTLSSFHKCRC IPYVREQFNNP*KNLRHLLVYQTRNLFSHCSEY VITLGFTDLFLCYFSNSSFVKKKKSNTFYVICCS YKPY*KSPLFKNLNVSNCITWPLYVLKPAFQCV DTFPRLLNST*LSSYSAPSMSQALY*PTEMLRE KKDLFLI*YPRKSNSLLC**SHIYK*LPSPLVFS SFSLLLYFIMIIQQAQVKVKNKVYA*GNSGLLV SLRKAKRR*GLNNSRKTNIYKTLN*CYT***HY LMSLRVQTQRDKALKMLFDLPRWSWWC*YLNSGY CFNLNCFVSEKHDPEDSTDYGHGSHGLHPSLLT CLLSSHFYI*TKMCSISLI*IHLTNKFFCFKNV LLSQVYYSGI*S*LISTNPL*ASSSQSVVSGRAV SASSGNLSQMQILGTTPDLHNQKLLGEGPKYLC FTKPTT*F*CTLNTEKTCSRQIPKQQLRRQLPS TAGYNCSIRASF*SSNSQVTLRLSTFTHK*KP*T GANVKPLASTQASIFSCPLTSI*LLRKTSDAKT *NSNEAI*TAVQLHF*DFT*Q*IIAHVHYFPDN LAYE*LIQL*RFNITDKM*TVSLKLGLQLWNFTA C*NNRFLRSLSAR*TLLSNLFMKVLKCLHLNLM ANLQRFSMYQM*LTATKLNLIFTL*PNEIYLKY IEYFILLYPDKIIIF*CTNISVIISKILFYYIA* E*TFVKL

Sequence NM_000091

GGGAGGGACGAACCGCGCGACCGAGCCCTACAAAACCCGCCCCGGCCGAGTGGCGAGGCGAGCTTTCCAGCCGGGCTCCCAGAGCCGCGCTGCGCAGGAG ACGCGGTGGCCTGAGAGCCTGAGGGTCCCCGGACTCGCCCAGGCTCTGAGCGCGCGCCCACCATGAGCGCCCGGACCGCCCCCAGGCCGCAGGTGCTCCT GCTGCCGCTCCTGCTGGTGCTCCTGGCGGCGGCGCCCGCAGCCAGCAAGGGTTGTGTCTGTAAAGACAAAGGCCAGTGCTTCTGTGACGGGGCCAAAGGG GAGAAGGGGGAGAAGGGCTTTCCTGGACCCCCCGGTTCTCCTGGCCAGAAAGGATTCACAGGTCCTGAAGGCTTGCCTGGACCGCAGGGACCCAAGGGCT TTCCAGGACTTCCAGGACTCACGGGTTCCAAAGGTGTAAGGGGAATAAGTGGATTGCCAGGATTTTCTGGTTCTCCTGGACTTCCAGGCACCCCAGGCAA TACCGGGCCTTACGGACTTGTCGGTGTACCAGGATGCAGTGGTTCTAAGGGTGAGCAGGGGTTTCCAGGACTCCCAGGGACACTGGGCTACCCAGGGATC CCGGGTGCTGCTGGTTTGAAAGGACAAAAGGGTGCTCCTGCTAAAGAAGAAGATATAGAACTTGATGCAAAAGGCGACCCCGGGTTGCCAGGGGCTCCAG GACCCCAGGGTTTGCCAGGCCCTCCAGGTTTTCCTGGGCCTGTTGGCCCACCTGGTCCTCCGGGATTCTTTGGCTTTCCAGGAGCCATGGGACCTAGAGG ACCTAAGGGTCACATGGGTGAAAGAGTGATAGGACATAAAGGAGAGCGGGGTGTGAAAGGGTTAACAGGACCCCCGGGACCACCAGGAACAGTTATTGTG ACCCTAACTGGCCCAGATAACAGAACGGACCTCAAGGGGGAAAAGGGAGACAAGGGAGCAATGGGCGAGCCTGGACCTCCTGGACCCTCAGGACTGCCTG GAGAATCATATGGATCTGAAAAGGGTGCTCCTGGAGACCCTGGCCTGCAGGGAAAACCCGGAAAAGATGGTGTTCCTGGCTTCCCTGGAAGTGAGGGAGT CAAGGGCAACAGGGGTTTCCCTGGGTTAATGGGTGAAGATGGCATTAAGGGACAGAAAGGGGACATTGGCCCTCCAGGATTTCGTGGTCCAACAGAATAT TATGACACATACCAGGAAAAGGGAGATGAAGGCACTCCAGGCCCACCAGGGCCCAGAGGAGCTCGTGGCCCACAAGGTCCCAGTGGTCCCCCCGGAGTTC CTGGAAGTCCTGGATCATCAAGGCCTGGCCTCAGAGGAGCCCCTGGATGGCCAGGCCTGAAAGGAAGTAAAGGGGAACGAGGCCGCCCAGGAAAGGATGC CATGGGGACTCCTGGGTCCCCAGGTTGTGCTGGTTCACCAGGTCTTCCAGGATCACCGGGACCTCCAGGACCGCCAGGTGACATCGTTTTTCGCAAGGGT CCACCTGGAGATCACGGACTGCCAGGCTATCTAGGGTCTCCAGGAATCCCAGGAGTTGATGGGCCCAAAGGAGAACCAGGCCTCCTGTGTACACAGTGCC CTTATATCCCAGGGCCTCCCGGTCTCCCAGGATTGCCAGGGTTACATGGTGTAAAAGGAATCCCAGGAAGACAAGGCGCAGCTGGCTTGAAAGGAAGCCC AGGGTCCCCAGGAAATACAGGTCTTCCAGGATTTCCAGGTTTCCCAGGTGCCCAGGGTGACCCAGGACTTAAAGGAGAAAAAGGTGAAACACTTCAGCCT GAGGGGCAAGTGGGTGTCCCAGGTGACCCGGGGCTCAGAGGCCAACCTGGGAGAAAGGGCTTGGATGGAATTCCTGGAACTCCGGGAGTGAAAGGATTAC CAGGACCTAAAGGCGAACTGGCTCTGAGTGGTGAGAAAGGGGACCAAGGTCCTCCAGGGGATCCTGGCTCCCCTGGGTCCCCAGGACCTGCAGGACCAGC TGGACCACCTGGCTACGGACCCCAAGGAGAACCTGGTCTCCAGGGCACGCAAGGAGTTCCTGGAGCCCCCGGACCACCCGGAGAAGCCGGCCCTAGGGGA GAGCTCAGTGTTTCAACACCAGTTCCAGGCCCACCAGGACCTCCAGGGCCCCCTGGCCATCCTGGCCCCCAAGGTCCACCTGGTATCCCTGGATCCCTGG GGAAATGTGGAGATCCTGGTCTTCCAGGGCCTGATGGTGAACCAGGAATTCCAGGAATTGGATTTCCTGGGCCTCCTGGACCTAAGGGAGACCAAGGTTT TCCAGGTACAAAAGGATCACTGGGTTGTCCTGGAAAAATGGGAGAGCCTGGGTTACCTGGAAAGCCAGGCCTCCCAGGAGCCAAGGGAGAACCAGCAGTA GCCATGCCTGGAGGACCAGGAACACCAGGTTTTCCAGGAGAAAGAGGCAATTCTGGGGAACATGGAGAAATTGGACTCCCTGGACTTCCAGGTCTCCCTG GAACTCCAGGAAATGAAGGGCTTGATGGACCACGAGGAGATCCAGGGCAGCCTGGACCACCTGGAGAACAAGGACCCCCAGGAAGGTGCATAGAGGGTCC CAGGGGAGCCCAAGGACTTCCAGGCTTAAATGGATTGAAAGGGCAACAAGGCAGAAGAGGTAAAACGGGGCCAAAGGGAGACCCAGGAATTCCAGGCTTG GATAGATCAGGATTTCCTGGAGAAACTGGATCACCAGGAATTCCAGGTCATCAAGGTGAAATGGGACCACTGGGTCAAAGAGGATATCCAGGAAATCCGG GAATTTTAGGGCCACCAGGTGAAGATGGAGTGATTGGGATGATGGGCTTTCCTGGAGCCATTGGCCCTCCAGGGCCCCCTGGGAACCCAGGCACACCAGG GCAGAGGGGGAGCCCTGGAATTCCAGGAGTAAAGGGCCAGAGAGGAACCCCAGGAGCCAAGGGGGAACAAGGAGATAAAGGAAATCCCGGGCCTTCAGAG ATATCCCACGTAATAGGGGACAAAGGAGAACCAGGTCTCAAAGGATTCGCAGGAAATCCAGGTGAGAAAGGAAACAGAGGCGTTCCAGGGATGCCAGGTT TAAAGGGCCTCAAAGGACTACCCGGACCAGCAGGACCACCAGGCCCCAGAGGAGATTTGGGCAGCACTGGGAATCCTGGAGAACCAGGACTGCGTGGTAT ACCAGGAAGCATGGGGAACATGGGCATGCCAGGTTCTAAAGGAAAAAGGGGAACTTTGGGATTCCCAGGTCGAGCAGGAAGACCAGGCCTCCCAGGTATT CATGGTCTCCAGGGAGATAAGGGAGAGCCAGGTTATTCAGAAGGTACAAGGCCAGGACCACCGGGACCAACGGGGGATCCAGGACTGCCGGGTGATATGG GAAAGAAAGGAGAAATGGGGCAACCTGGCCCACCTGGACATTTGGGGCCTGCTGGACCTGAGGGAGCCCCTGGAAGTCCTGGAAGTCCTGGCCTCCCAGG AAAGCCAGGTCCTCATGGTGATTTGGGTTTTAAAGGAATCAAAGGCCTCCTGGGCCCTCCAGGAATCAGAGGCCCTCCAGGTCTTCCAGGATTTCCAGGA TCTCCTGGACCAATGGGTATAAGAGGTGACCAAGGACGTGATGGAATTCCTGGTCCAGCCGGAGAAAAGGGAGAAACGGGTTTATTGAGGGCCCCTCCAG GCCCAAGAGGGAACCCTGGTGCTCAAGGAGCCAAAGGAGACAGGGGAGCCCCAGGTTTTCCTGGCCTCCCGGGCAGAAAAGGGGCCATGGGAGATGCTGG ACCTCGAGGACCCACAGGCATAGAAGGATTCCCAGGGCCACCAGGTCTGCCCGGTGCAATTATCCCTGGCCAGACAGGAAATCGTGGTCCACCAGGCTCA AGAGGAAGCCCAGGTGCGCCTGGTCCCCCTGGACCTCCAGGGAGTCATGTAATAGGCATAAAAGGAGACAAAGGGTCTATGGGCCACCCTGGCCCAAAAG GTCCACCTGGAACTGCAGGAGACATGGGACCACCAGGTCGTCTGGGAGCACCAGGTACTCCAGGTCTTCCAGGACCCAGAGGTGATCCTGGATTCCAGGG GTTTCCAGGCGTGAAAGGAGAAAAGGGTAATCCTGGATTTCTAGGATCCATTGGACCTCCAGGACCAATTGGGCCAAAAGGACCACCTGGTGTACGTGGA GACCCTGGCACACTTAAGATTATCTCCCTTCCAGGAAGCCCAGGGCCACCTGGCACACCTGGAGAACCAGGGATGCAGGGAGAACCTGGGCCACCAGGGC CACCTGGAAACCTAGGACCCTGTGGGCCAAGAGGTAAGCCAGGCAAGGATGGAAAACCAGGAACTCCTGGACCAGCTGGAGAAAAAGGCAACAAAGGTTC TAAAGGAGAGCCAGGACCAGCTGGATCAGATGGATTGCCAGGTTTGAAAGGAAAACGTGGAGACAGTGGATCACCTGCAACCTGGACAACGAGAGGCTTT GTCTTCACCCGACACAGTCAAACCACAGCAATTCCTTCATGTCCAGAGGGGACAGTGCCACTCTACAGTGGGTTTTCTTTTCTTTTTGTACAAGGAAATC AACGAGCCCACGGACAAGACCTTGGAACTCTTGGCAGCTGCCTGCAGCGATTTACCACAATGCCATTCTTATTCTGCAATGTCAATGATGTATGTAATTT TGCATCTCGAAATGATTATTCATACTGGCTGTCAACACCAGCTCTGATGCCAATGAACATGGCTCCCATTACTGGCAGAGCCCTTGAGCCTTATATAAGC AGATGCACTGTTTGTGAAGGTCCTGCGATCGCCATAGCCGTTCACAGCCAAACCACTGACATTCCTCCATGTCCTCACGGCTGGATTTCTCTCTGGAAAG GATTTTCATTCATCATGTTCACAAGTGCAGGTTCTGAGGGCACCGGGCAAGCACTGGCCTCCCCTGGCTCCTGCCTGGAAGAATTCCGAGCCAGCCCATT TCTAGAATGTCATGGAAGAGGAACGTGCAACTACTATTCAAATTCCTACAGTTTCTGGCTGGCTTCATTAAACCCAGAAAGAATGTTCAGAAAGCCTATT CCATCAACTGTGAAAGCTGGGGAATTAGAAAAAATAATAAGTCGCTGTCAGGTGTGCATGAAGAAAAGACACTGAAGCTAAAAAAGACAGCAGAACTGCT ATTTTTCATCCTAAAGAACAAAGTAATGACAGAACATGCTGTTATTTAGGTATTTTTCTTTAACCAAACAATATTGCTCCATGATGACTTAGTACAAAGT TTCAATTTGTTTCCCCACAAAACAAAGCAATTCTTTCAAGTCAGTTCTGTGATCTGGGTCTCTAATCTGTGCTGTTTCAAAGTTCTCTGTGGCAAAGCAG CAACTATTCACAAAATATCACCAAAAACCTATTCCACTTACATCCAAGGCACTGTCACTACGGTGATTGTATGAAGTTTGAATGCTGCAAGTTATGAAAT ATTTGGCCCGCTGGATTCCCACATTTGTCTTCTTTCTGTCTTTAAGACTCAGGGAGGCTAAATCAGTGTTTGATTGCCCCGCCAACCCTTCCTGAAACTT CAGACCCTGGGTAGGGGAAGAGAAGGGGGCATGTGGTATCCTGGAGCATTGTGTATAGAACTGGATTTTCAGACCTGCTGAGGACCGTAAGGCCTGATGG AACACAGAACTGAACTGAGGTTCATGGATTTTCCAGGACTGTTTCAAACATGCCCATTACTAACGGCAAAAGGGGGATTCCCTGATGGAACCATAATACC CTTGGAAATACTGTATGGTTTTGTTTTGTTTTGTTGGTTTTTAAAGATTTTTGTTTGTTTATTGAATTCATTTCACTGTAGCTCTAAAATCTGCTTGTAT TCCAAGCATATAAAATTTTCCCCCTTAGTGAATTAGTTTTAAAATGATATTGTTATATACATACTATGAAATATGTATAACTTTAACTTCTGTTTTACCA GCATACCCACACAAATAACAAGAATACTACTTATGAAATGTGCACTTTATCCTCATTCCATAAATGTCGGTGCATACCTTATGTAAGGGAGCAGTTCAAT AATCCATGAAAGAACTTAAGGCATTTGTTGGTTTATCAGACTCGGAATCTATTTTCTCATTGCTCTGAATATGTCATCACTCTAGGTTTTACAGATTTAT TCCTTTGTTACTTCTCTAATTCTTCCTTTGTAAAAAAAAAAAAAAGCAACACTTTTTATGTTATATGTTGTTCTTACAAACCATACTGAAAGAGTCCATT GTTTAAAAATCTTAATGTATCAAACTGTATAACTTGGCCGCTGTATGTCTTAAAACCTGCTTTTCAATGTGTTGATACATTCCCAAGGTTACTTAATTCA ACTTAACTATCATCTTATTCAGCACCAAGCATGTCCCAGGCACTGTACTAACCTACAGAGATGCTAAGAGAAAAAAAAGACTTGTTTCTGATCTAATATC CCAGAAAAAGTAACTCATTGCTCTGTTAATAATCTCACATATACAAGTAGCTTCCCTCCCCTCTAGTTTTTTCTTCCTTTTCACTGCTGTTATATTTCAT CATGATAATTCAGCAGGCCCAAGTAAAGGTTAAAAATAAGGTCTATGCCTAGGGAAACTCAGGGCTTCTAGTTTCTCTTAGAAAAGCTAAGAGAAGATAA GGTCTGAATAATAGCAGAAAAACCAACATCTACAAAACATTAAACTAGTGTTATACTTGATGATAACACTATTTGATGAGTCTTAGAGTCCAGACACAAA GAGACAAAGCTTTGAAGATGCTTTTTGATCTACCTAGGTGGAGTTGGTGGTGCTGATATTTAAATTCAGGCTACTGCTTCAATCTCAATTGCTTTGTAAG TGAAAAACATGACCCAGAGGACAGCACAGACTATGGCCATGGCTCACATGGTTTACATCCTTCACTGCTCACGTGTTTGCTGTCAAGCCATTTTTACATC TAAACTAAGATGTGCAGCATTTCACTTATTTAGATTCACTTAACAAACAAATTTTTCTGCTTTAAAAATGTCTTATTGTCCCAAGTGTACTATAGCGGCA TATAGAGCTAGCTAATCTCTACAAACCCTCTGTAGGCCAGTAGTTCTCAAAGTGTGGTCTCTGGAAGAGCAGTATCAGCATCATCTGGGAACTTGTCACA GATGCAGATTCTAGGGACCACTCCAGACCTACACAATCAGAAACTCTTGGGGGAGGGCCCGAAATATCTATGTTTTACCAAGCCCACCACATGATTCTGA TGTACTCTAAATACTGAGAAAACCTGTTCTAGACAAATACCCAAGCAACAACTCCGCAGGCAGTTACCAAGTACGGCTGGCTACAACTGCTCCATCCGTG CCTCTTTTTAAAGTTCAAACTCACAGGTGACTCTAAGGTTATCTACTTTTACTCATAAGTAAAAGCCCTAGACTGGTGCTAATGTCAAACCACTGGCCTC CACTCAGGCCTCCATCTTCTCATGCCCTCTTACCAGTATTTAACTTCTGAGGAAGACAAGTGATGCTAAAACCTGAAATTCCAATGAAGCCATATGAACA GCTGTTCAGTTGCACTTCTAAGACTTTACTTAGCAGTAAATTATAGCTCATGTGCATTATTTTCCAGATAACTTAGCTTATGAGTAGCTTATACAATTAT GAAGATTTAATATTACAGATAAAATGTAAACTGTTTCTTTAAAATTGGGGCTTCAACTTTGGAATTTCACAGCGTGCTAAAATAACAGATTTCTCAGAAG TCTTTCAGCAAGATAAACATTATTAAGTAACTTATTTATGAAAGTATTAAAATGCTTACATTTGAACTTGATGGCTAACTTACAAAGATTCTCTATGTAT CAAATGTAACTTACTGCGACTAAACTTAATTTAATATTTACTCTATAACCAAATGAAATATATTTAAAATATATTGAATATTTTATATTGTTATATCCTG ACAAGATTATAATATTTTAATGTACTAATATTTCTGTAATTATATCTAAAATATTATTTTATTATATTGCCTAAGAATAAACATTTGTTAAATTGG

refseq_COL4A3.F1 (forward primer)
refseq_COL4A3.R1 (reverse primer)
Single exon skipping

Frame 0

GRDEPRDRALQNPPRPSGEASFPAGLPEPRCAG DAVA*EPEGPRTRPGSERAPTMSARTAPRPQVLL LPLLLVLLAAAPAASKGCVCKDKGQCFCDGAKG EKGEKGFPGPPGSPGQKGFTGPEGLPGPQGPKG FPGLPGLTGSKGVRGISGLPGFSGSPGLPGTPGN TGPYGLVGVPGCSGSKGEQGFPGLPGTLGYPGI PGAAGLKGQKGAPAKEEDIELDAKGDPGLPGAP GPQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPRG PKGHMGERVIGHKGERGVKGLTGPPGPPGTVIV TLTGPDNRTDLKGEKGDKGAMGEPGPPGPSGLP GESYGSEKGAPGDPGLQGKPGKDGVPGFPGSEGV KGNRGFPGLMGEDGIKGQKGDIGPPGFRGPTEY YDTYQEKGDEGTPGPPGPRGARGPQGPSGPPGV PGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDA MGTPGSPGCAGSPGLPGSPGPPGPPGDIVFRKG PPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQC PYIPGPPGLPGLPGLHGVKGIPGRQGAAGLKGSP GSPGNTGLPGFPGFPGAQGDPGLKGEKGETLQP EGQVGVPGDPGLRGQPGRKGLDGIPGTPGVKGL PGPKGELALSGEKGDQGPPGDPGSPGSPGPAGPA GPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRG ELSVSTPVPGPPGPPGPPGHPGPQGPPGIPGSL GKCGDPGLPGPDGEPGIPGIGFPGPPGPKGDQGF PGTKGSLGCPGKMGEPGLPGKPGLPGAKGEPAV AMPGGPGTPGFPGERGNSGEHGEIGLPGLPGLP GTPGNEGLDGPRGDPGQPGPPGEQGPPGRCIEGP RGAQGLPGLNGLKGQQGRRGKTGPKGDPGIPGL DRSGFPGETGSPGIPGHQGEMGPLGQRGYPGNP GILGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPG QRGSPGIPGVKGQRGTPGAKGEQGDKGNPGPSE ISHVIGDKGEPGLKGFAGNPGEKGNRGVPGMPG LKGLKGLPGPAGPPGPRGDLGSTGNPGEPGLRGI PGSMGNMGMPGSKGKRGTLGFPGRAGRPGLPGI HGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDM GKKGEMGQPGPPGHLGPAGPEGAPGSPGSPGLPG KPGPHGDLGFKGIKGLLGPPGIRGPPGLPGFPG SPGPMGIRGDQGRDGIPGPAGEKGETGLLRAPP GPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAG PRGPTGIEGFPGPPGLPGAIIPGQTGNRGPPGS RGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPK GPPGTAGDMGPPGRLGAPGTPGLPGPRGDPGFQG FPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVRG DPGTLKIISLPGSPGPPGTPGEPGMQGEPGPPG PPGNLGPCGPRGKPGKDGKPGTPGPAGEKGNKGS KGEPGPAGSDGLPGLKGKRGDSGSPATWTTRGF VFTRHSQTTAIPSCPEGTVPLYSGFSFLFVQGN QRAHGQDLGTLGSCLQRFTTMPFLFCNVNDVCNF ASRNDYSYWLSTPALMPMNMAPITGRALEPYIS RCTVCEGPAIAIAVHSQTTDIPPCPHGWISLWK GFSFIMFTSAGSEGTGQALASPGSCLEEFRASPF LECHGRGTCNYYSNSYSFWLASLNPERMFRKPI PSTVKAGELEKIISRCQVCMKKRH*S*KRQQNC YFSS*RTK**QNMLLFRYFSLTKQYCSMMT*YKV SICFPTKQSNSFKSVL*SGSLICAVSKFSVAKQ QLFTKYHQKPIPLTSKALSLR*LYEV*MLQVMK YLARWIPTFVFFLSLRLREAKSVFDCPANPS*NF RPWVGEEKGACGILEHCV*NWIFRPAEDRKA*W NTELN*GSWIFQDCFKHAHY*RQKGDSLMEP*Y PWKYCMVLFCFVGF*RFLFVY*IHFTVALKSACI PSI*NFPP**ISFKMILLYTYYEICITLTSVLP AYPHK*QEYYL*NVHFILIP*MSVHTLCKGAVQ *SMKELKAFVGLSDSESIFSLL*ICHHSRFYRFI PLLLL*FFLCKKKKKQHFLCYMLFLQTILKESI V*KS*CIKLYNLAAVCLKTCFSMC*YIPKVT*F NLTIILFSTKHVPGTVLTYRDAKRKKRLVSDLIS QKK*LIALLIISHIQVASLPSSFFFLFTAVIFH HDNSAGPSKG*K*GLCLGKLRASSFS*KS*EKI RSE**QKNQHLQNIKLVLYLMITLFDES*SPDTK RQSFEDAF*ST*VELVVLIFKFRLLLQSQLLCK *KT*PRGQHRLWPWLTWFTSFTAHVFAVKPFLH LN*DVQHFTYLDSLNKQIFLL*KCLIVPSVL*RH IELANLYKPSVGQ*FSKCGLWKSSISIIWELVT DADSRDHSRPTQSETLGGGPEISMFYQAHHMIL MYSKY*ENLF*TNTQATTPQAVTKYGWLQLLHPC LFLKFKLTGDSKVIYFYS*VKALDWC*CQTTGL HSGLHLLMPSYQYLTSEEDK*C*NLKFQ*SHMN SCSVALLRLYLAVNYSSCALFSR*LSL*VAYTIM KI*YYR*NVNCFFKIGASTLEFHSVLK*QISQK SFSKINIIK*LIYESIKMLTFELDG*LTKILYV SNVTYCD*T*FNIYSITK*NIFKIY*IFYIVIS* QDYNILMY*YFCNYI*NIILLYCLRINIC*I

Frame 1

GGTNRATEPYKTRPGRVARRAFQPGSQSRAAQE TRWPESLRVPGLAQALSARPP*APGPPPGRRCS CCRSCWCSWRRRPQPARVVSVKTKASASVTGPKG RRGRRAFLDPPVLLARKDSQVLKACLDRRDPRA FQDFQDSRVPKV*GE*VDCQDFLVLLDFQAPQA IPGLTDLSVYQDAVVLRVSRGFQDSQGHWATQGS RVLLV*KDKRVLLLKKKI*NLMQKATPGCQGLQ DPRVCQALQVFLGLLAHLVLRDSLAFQEPWDLE DLRVTWVKE**DIKESGV*KG*QDPRDHQEQLL* P*LAQITERTSRGKRETREQWASLDLLDPQDCL ENHMDLKRVLLETLACRENPEKMVFLASLEVRE SRATGVSLG*WVKMALRDRKGTLALQDFVVQQNI MTHTRKREMKALQAHQGPEELVAHKVPVVPPEF LEVLDHQGLASEEPLDGQA*KEVKGNEAAQERM PWGLLGPQVVLVHQVFQDHRDLQDRQVTSFFARV HLEITDCQAI*GLQESQELMGPKENQASCVHSA LISQGLPVSQDCQGYMV*KESQEDKAQLA*KEA QGPQEIQVFQDFQVSQVPRVTQDLKEKKVKHFSL RGKWVSQVTRGSEANLGERAWMEFLELRE*KDY QDLKANWL*VVRKGTKVLQGILAPLGPQDLQDQ LDHLATDPKENLVSRARKEFLEPPDHPEKPALGE SSVFQHQFQAHQDLQGPLAILAPKVHLVSLDPW GNVEILVFQGLMVNQEFQELDFLGLLDLRETKV FQVQKDHWVVLEKWESLGYLESQASQEPRENQQ* PCLEDQEHQVFQEKEAILGNMEKLDSLDFQVSL ELQEMKGLMDHEEIQGSLDHLENKDPQEGA*RV PGEPKDFQA*MD*KGNKAEEVKRGQRETQEFQAW IDQDFLEKLDHQEFQVIKVKWDHWVKEDIQEIR EF*GHQVKME*LG*WAFLEPLALQGPLGTQAHQ GRGGALEFQE*RAREEPQEPRGNKEIKEIPGLQR YPT**GTKENQVSKDSQEIQVRKETEAFQGCQV *RASKDYPDQQDHQAPEEIWAALGILENQDCVV YQEAWGTWACQVLKEKGELWDSQVEQEDQASQVF MVSREIRESQVIQKVQGQDHRDQRGIQDCRVIW ERKEKWGNLAHLDIWGLLDLREPLEVLEVLASQ ESQVLMVIWVLKESKASWALQESEALQVFQDFQD LLDQWV*EVTKDVMEFLVQPEKREKRVY*GPLQ AQEGTLVLKEPKETGEPQVFLASRAEKGPWEML DLEDPQA*KDSQGHQVCPVQLSLARQEIVVHQAQ EEAQVRLVPLDLQGVM**A*KETKGLWATLAQK VHLELQETWDHQVVWEHQVLQVFQDPEVILDSR GFQA*KEKRVILDF*DPLDLQDQLGQKDHLVYVE TLAHLRLSPFQEAQGHLAHLENQGCRENLGHQG HLET*DPVGQEVSQARMENQELLDQLEKKATKV LKESQDQLDQMDCQV*KENVETVDHLQPGQREAL SSPDTVKPQQFLHVQRGQCHSTVGFLFFLYKEI NEPTDKTLELLAAACSDLPQCHSYSAMSMMYVI LHLEMIIHTGCQHQL*CQ*TWLPLLAEPLSLI*A DALFVKVLRSP*PFTAKPLTFLHVLTAGFLSGK DFHSSCSQVQVLRAPGKHWPPLAPAWKNSEPAH F*NVMEEERATTIQIPTVSGWLH*TQKECSESLF HQL*KLGN*KK**VAVRCA*RKDTEAKKDSRTA IFHPKEQSNDRTCCYLGIFL*PNNIAP**LSTK FQFVSPQNKAILSSQFCDLGL*SVLFQSSLWQSS NYSQNITKNLFHLHPRHCHYGDCMKFECCKL*N IWPAGFPHLSSFCL*DSGRLNQCLIAPPTLPET SDPG*GKRRGHVVSWSIVYRTGFSDLLRTVRPDG TQN*TEVHGFSRTVSNMPITNGKRGIP*WNHNT LGNTVWFCFVLLVFKDFCLFIEFISL*L*NLLV FQAYKIFPLSELVLK*YCYIHTMKYV*L*LLFYQ HTHTNNKNTTYEMCTLSSFHKCRCIPYVREQFN NP*KNLRHLLVYQTRNLFSHCSEYVITLGFTDL FLCYFSNSSFVKKKKSNTFYVICCSYKPY*KSPL FKNLNVSNCITWPLYVLKPAFQCVDTFPRLLNS T*LSSYSAPSMSQALY*PTEMLREKKDLFLI*Y PRKSNSLLC**SHIYK*LPSPLVFSSFSLLLYFI MIIQQAQVKVKNKVYA*GNSGLLVSLRKAKRR* GLNNSRKTNIYKTLN*CYT***HYLMSLRVQTQ RDKALKMLFDLPRWSWWC*YLNSGYCFNLNCFVS EKHDPEDSTDYGHGSHGLHPSLLTCLLSSHFYI *TKMCSISLI*IHLTNKFFCFKNVLLSQVYYSG I*S*LISTNPL*ASSSQSVVSGRAVSASSGNLSQ MQILGTTPDLHNQKLLGEGPKYLCFTKPTT*F* CTLNTEKTCSRQIPKQQLRRQLPSTAGYNCSIR ASF*SSNSQVTLRLSTFTHK*KP*TGANVKPLAS TQASIFSCPLTSI*LLRKTSDAKT*NSNEAI*T AVQLHF*DFT*Q*IIAHVHYFPDNLAYE*LIQL *RFNITDKM*TVSLKLGLQLWNFTAC*NNRFLRS LSAR*TLLSNLFMKVLKCLHLNLMANLQRFSMY QM*LTATKLNLIFTL*PNEIYLKYIEYFILLYP DKIIIF*CTNISVIISKILFYYIA*E*TFVKL

Frame 2

EGRTARPSPTKPAPAEWRGELSSRAPRAALRRR RGGLRA*GSPDSPRL*ARAHHERPDRPQAAGAP AAAPAGAPGGGARSQQGLCL*RQRPVLL*RGQR GEGGEGLSWTPRFSWPERIHRS*RLAWTAGTQGL SRTSRTHGFQRCKGNKWIARIFWFSWTSRHPRQ YRALRTCRCTRMQWF*G*AGVSRTPRDTGLPRD PGCCWFERTKGCSC*RRRYRT*CKRRPRVARGSR TPGFARPSRFSWACWPTWSSGILWLSRSHGT*R T*GSHG*KSDRT*RRAGCERVNRTPGTTRNSYC DPNWPR*QNGPQGGKGRQGSNGRAWTSWTLRTAW RIIWI*KGCSWRPWPAGKTRKRWCSWLPWK*GS QGQQGFPWVNG*RWH*GTERGHWPSRISWSNRI L*HIPGKGR*RHSRPTRAQRSSWPTRSQWSPRSS WKSWIIKAWPQRSPWMARPERK*RGTRPPRKGC HGDSWVPRLCWFTRSSRITGTSRTAR*HRFSQG STWRSRTARLSRVSRNPRS*WAQRRTRPPVYTVP LYPRASRSPRIARVTWCKRNPRKTRRSWLERKP RVPRKYRSSRISRFPRCPG*PRT*RRKR*NTSA *GASGCPR*PGAQRPTWEKGLGWNSWNSGSERIT RT*RRTGSEW*ERGPRSSRGSWLPWVPRTCRTS WTTWLRTPRRTWSPGHARSSWSPRTTRRSRP*G RAQCFNTSSRPTRTSRAPWPSWPPRSTWYPWIPG EMWRSWSSRA*W*TRNSRNWISWASWT*GRPRF SRYKRITGLSWKNGRAWVTWKARPPRSQGRTSS SHAWRTRNTRFSRRKRQFWGTWRNWTPWTSRSPW NSRK*RA*WTTRRSRAAWTTWRTRTPRKVHRGS QGSPRTSRLKWIERATRQKR*NGAKGRPRNSRL G*IRISWRNWITRNSRSSR*NGTTGSKRISRKSG NFRATR*RWSDWDDGLSWSHWPSRAPWEPRHTR AEGEPWNSRSKGPERNPRSQGGTRR*RKSRAFR DIPRNRGQRRTRSQRIRRKSR*ERKQRRSRDARF KGPQRTTRTSRTTRPQRRFGQHWESWRTRTAWY TRKHGEHGHARF*RKKGNFGIPRSSRKTRPPRY SWSPGR*GRARLFRRYKARTTGTNGGSRTAG*YG KERRNGATWPTWTFGACWT*GSPWKSWKSWPPR KARSSW*FGF*RNQRPPGPSRNQRPSRSSRISR ISWTNGYKR*PRT*WNSWSSRRKGRNGFIEGPSR PKREPWCSRSQRRQGSPRFSWPPGQKRGHGRCW TSRTHRHRRIPRATRSARCNYPWPDRKSWSTRL KRKPRCAWSPWTSRESCNRHKRRQRVYGPPWPKR STWNCRRHGTTRSSGSTRYSRSSRTQR*SWIPG VSRRERRKG*SWISRIHWTSRTNWAKRTTWCTW RPWHT*DYLPSRKPRATWHTWRTRDAGRTWATRA TWKPRTLWAKR*ARQGWKTRNSWTSWRKRQQRF *RRARTSWIRWIARFERKTWRQWITCNLDNERL CLHPTQSNHSNSFMSRGDSATLQWVFFSFCTRKS TSPRTRPWNSWQLPAAIYHNAILILQCQ*CM*F CISK*LFILAVNTSSDANEHGSHYWQSP*ALYK QMHCL*RSCDRHSRSQPNH*HSSMSSRLDFSLER IFIHHVHKCRF*GHRASTGLPWLLPGRIPSQPI SRMSWKRNVQLLFKFLQFLAGFIKPRKNVQKAY SINCESWGIRKNNKSLSGVHEEKTLKLKKTAELL FFILKNKVMTEHAVI*VFFFNQTILLHDDLVQS FNLFPHKTKQFFQVSSVIWVSNLCCFKVLCGKA ATIHKISPKTYSTYIQGTVTTVIV*SLNAASYEI FGPLDSHICLLSVFKTQGG*ISV*LPRQPFLKL QTLGRGREGGMWYPGALCIELDFQTC*GP*GLM EHRTELRFMDFPGLFQTCPLLTAKGGFPDGTIIP LEILYGFVLFCWFLKIFVCLLNSFHCSSKICLY SKHIKFSPLVN*F*NDIVIYIL*NMYNFNFCFT SIPTQITRILLMKCALYPHSINVGAYLM*GSSSI IHERT*GICWFIRLGIYFLIALNMSSL*VLQIY SFVTSLILPL*KKKKATLFMLYVVLTNHTERVH CLKILMYQTV*LGRCMS*NLLFNVLIHSQGYLIQ LNYHLIQHQACPRHCTNLQRC*EKKKTCF*SNI PEKVTHCSVNNLTYTSSFPPL*FFLPFHCCYIS S**FSRPK*RLKIRSMPRETQGF*FLLEKLREDK V*IIAEKPTSTKH*TSVILDDNTI**VLESRHK ETKL*RCFLIYLGGVGGADI*IQATASISIAL* VKNMTQRTAQTMAMAHMVYILHCSRVCCQAIFTS KLRCAAFHLFRFT*QTNFSALKMSYCPKCTIAA YRAS*SLQTLCRPVVLKVWSLEEQYQHHLGTCH RCRF*GPLQTYTIRNSWGRARNIYVLPSPPHDSD VL*ILRKPVLDKYPSNNSAGSYQVRLATTAPSV PLFKVQTHR*L*GYLLLLISKSPRLVLMSNHWP PLRPPSSHALLPVFNF*GRQVMLKPEIPMKPYEQ LFSCTSKTLLSSKL*LMCIIFQIT*LMSSLYNY EDLILQIKCKLFL*NWGFNFGISQRAKITDFSE VFQQDKHY*VTYL*KY*NAYI*T*WLTYKDSLCI KCNLLRLNLI*YLLYNQMKYI*NILNILYCYIL TRL*YFNVLIFL*LYLKYYFIILPKNKHLLNW