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Sequences

Sequence NM_004437

GCCCCGGCGGGGCAAAGTGGCAGGAACCTCTTAAAGGGCGAGAGCGGCGCGGAGCCAGAACGCGGTCGGCCCGGTCCCCGCCGCACCCAGCCCAGAGAAG
AGTTTAGTGACTGAGGCCGAAAATTCACAGCACCAACAGAAGGAAGAGGGTGAGGAAGCCATAAACTCAGGCCAACAAGAACCTCAGCAGGAGGAATCTT
GTCAAACAGCAGCTGAAGGAGATAATTGGTGTGAACAGAAGCTGAAAGCTTCTAATGGAGACACTCCTACACATGAAGACTTGACCAAGAACAAGGAGCG
GACATCAGAAAGCAGAGGACTTTCACGACTATTCTCCTCGTTTCTCAAAAGGCCCAAATCTCAGGTGTCCGAGGAAGAAGGCAAAGAAGTAGAGTCAGAT
AAAGAAAAAGGTGAAGGAGGTCAGAAAGAGATAGAATTTGGAACCAGTCTTGATGAAGAGATCATTTTAAAGGCCCCAATTGCAGCTCCTGAACCGGAAC
TCAAAACAGACCCATCTTTGGATCTTCATTCATTAAGCAGTGCAGAAACACAGCCTCACCATTACAATTAAGAATTATTTTCAGAGTCTTCTTATTTCTG
AAGCATGTGAATATTATCTGCATCGTTAAAAGTCCTGCTCAGGAAGAACTCAGAGAAGATCCAGATTTTGAAATTAAGGAAGGAGAAGGACTTGAAGAGT
GCTCCAAAATAGAAGTAAAAGAAGAAAGCCCTCAATCAAAAGCAGAAACAGAATTAAAAGCTTCCCAAAAACCAATCAGAAAACACAGGAACATGCACTG
CAAGGTTTCTTTGTTGGATGACACAGTTTATGAATGTGTTGTGGAGAAACATGCTAAGGGACAAGATTTGCTTAAACGAGTATGTGAGCATCTCAATCTT
TTGGAAGAAGACTATTTTGGTCTAGCCATTTGGGATAACGCAACCTCTAAGACATGGCTGGATTCCGCCAAAGAAATAAAAAAGCAGGTTCGTGGTGTCC
CTTGGAATTTTACATTTAATGTAAAGTTTTATCCACCTGACCCAGCACAGTTAACAGAAGACATAACAAGATATTATTTATGTCTTCAGCTTCGGCAGGA
CATAGTTGCAGGACGTCTGCCCTGTTCCTTTGCAACCTTAGCATTATTAGGTTCTTACACCATCCAGTCTGAACTGGGAGACTACGACCCAGAACTCCAT
GGCGTGGATTATGTTAGTGATTTTAAACTGGCCCCGAATCAGACCAAGGAACTTGAAGAGAAGGTCATGGAACTGCATAAGTCATACAGGTCCATGACTC
CAGCTCAGGCTGACTTGGAGTTTCTTGAGAATGCCAAAAAGTTGTCTATGTATGGAGTTGATCTTCATAAAGCAAAGGACTTGGAAGGAGTAGATATCAT
CCTAGGTGTCTGCTCTAGTGGCCTTCTGGTTTACAAAGATAAGCTGAGAATTAACCGCTTCCCTTGGCCCAAAGTGCTGAAGATTTCTTATAAACGTAGT
AGCTTTTTCATCAAGATTCGGCCTGGAGAGCAAGAGCAGTATGAAAGTACCATCGGATTCAAACTTCCCAGTTACCGAGCAGCTAAGAAATTATGGAAAG
TCTGTGTAGAACATCACACGTTTTTCAGATTGACATCTACAGACACCATTCCCAAAAGCAAATTTCTTGCGCTAGGATCCAAATTTCGATACAGTGGCCG
GACTCAAGCTCAGACCAGGCAAGCTAGTGCTCTAATTGACAGGCCTGCCCCACACTTCGAGCGTACAGCAAGTAAACGGGCGTCCCGGAGCCTCGATGGA
GCAGCAGCTGTCGATTCGGCAGACCGAAGTCCTCGGCCCACTTCTGCACCTGCCATTACTCAGGGTCAGGTTGCAGAAGGTGGCGTCCTAGATGCCTCTG
CTAAAAAAACAGTGGTCCCTAAAGCACAGAAGGAAACAGTGAAGGCTGAAGTGAAAAAGGAAGACGAGCCACCTGAGCAAGCTGAGCCAGAGCCCACAGA
AGCATGGAAGAAAAAGAGAGAAAGACTAGATGGTGAAAACATTTATATCAGACATAGCAATTTAATGTTGGAGGATTTAGACAAGAGTCAAGAGGAGATC
AAAAAACATCATGCCAGCATCAGTGAGCTGAAAAAGAACTTCATGGAGTCTGTACCAGAACCACGGCCTAGTGAATGGGATAAACGCTTATCCACTCACT
CACCCTTCCGAACTCTTAACATCAATGGGCAAATCCCCACAGGAGAAGGACCTCCCCTGGTGAAGACACAAACTGTCACCATCTCAGATAATGCCAATGC
TGTGAAAAGTGAAATCCCAACCAAAGACGTCCCTATTGTCCACACTGAGACCAAGACCATCACTTATGAGGCTGCCCAGACTGTAAAAGGTGGGATTTCA
GAGACACGTATTGAAAAGAGAATTGTGATCACAGGAGATGCTGATATTGACCATGATCAGGTCCTTGTACAAGCCATCAAGGAGGCAAAGGAGCAGCACC
CAGACATGTCAGTGACCAAGGTGGTCGTCCACCAGGAGACCGAGATTGCTGATGAGTGAGCTCAGGAACTAACCTACCCCAACTCTGCCCTTCTCCCATC
CAAGAGAAACCAGCAAAATGATAAAGAAGCTAACCTGCCATAGTCAGACTTCAGACTTTCAAGATTATTCTAAATCACCAGAAAATTAATTTCAGTTTCT
ATTGGGAGTTTATACCAAGAGATTCTTCTAGATCTCATTGATCCTTTTGAAGAGCTTTTTCTATATTAGGATATCAGAATTGTTCAACTTTTCACTCTAT
AGACTGTTTTAAGAGTTTTGGGGTTTTTTTAATTGGGTGGTTTGTAACCCCTTCAGCCTAGCCTCTCTGCCCATTTATTTCCAACCCCAACAGACACTGA
CAGGGTCCATGGAATTCTTCGGGAAATCCTCCAAGGACTCTTGTCAGCTGTGTTGGAAGCCAAAGCCAGCTTAGTGGGACTTCCGCGTCTCTCCCTAGTC
TTATCCCCTTTGGATGATGGCAGAAACTTCATGAACCAGCCCTTTCTCAGAGCCAGTGATGTGAGTGTATCAGAATGCCAGGGAGGGCACCAGCCCTGAT
CCACAGACCTCGGAAAGATGCCCCTGTTCCTTTGTTGCGGGTGGTTTTGGTAAGGCAGAGCCCTCTGCTGAGAATGTAGTATTGTTTTTCCCCTCTCCCT
CCTGCTTTCTTTTTGGAGCTTCTTTGGGTCAAAGACATGGAAGTTGCTTCAGATATCTGATACTGTGAATGTTTGAACATATCCGTGGCCTTCACCTCTC
CAGCTACCCTTTTACCTCATCAGAAGCAGTGGCTCAGCTAAGTGCTCCCCCTAGCTCCCATCTCAGGAGACCAAATCTCACAGAAAAATAGGCACTTTGG
GCCAAAAGCTCTAATGGAACATTTTTAGTGGTGATTTGGGGAAGGAAAGTTAATGAGGTTTTTAAAATAAGGTTTTCTAGTTTTGAGAGTGTGCACTTCA
CACAGGGGAATGGGGTTACTTCTGTCTGATCCTGGGCCTTTCTTTCATCCCAAATGACAAGGAATGTGGCTCAGAGAAGGGTTTTTCTTTTTTGACCTTT
CTTCTCTCAACAGGAACCTGCCTGAGGACACCCTTCTAGAGCAAGGAATTGACTTTTAGGAGCCGTTCTCCCCACAAGACACCACATGACAAGGGGTATA
AGCCCCAGCCCTGCTCATTCCCACTCACCAGCTGAGGTCTGTCAGGTTTTGAAGGCTTGATTTTGTGGTGGGTTTGGGGCTTAGTTTTCCTTTTTTTCAT
TTTGATTTTTGAAAGTGAAGATGATGCCCTAATTCCTGGTAAGGATTTGGGGCATAGTTTTTTGTTTTTTTGAGACGGAGTTTCGCTCTTGTTGCCCAAG
CTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCAGTTCTCTTGCCTCAGCCTCCCAAGTAGCTGGGATGACAGGCG
CACACCACCACGCCCAGCAAATTTTTTGTATTTTTAGTAGAAACGGGATTTCACCTTGTTAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCAC
CTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCCGGCCGATTTGGGGCATTTTTATTTAACAGAACTTCTCTAACCTTCCAACTGCT
TCCCACAAACACATTGGCCTCAAGGCTCCTTAGAATCCCAGTTCCAGCTTCCTAAAATAGACAGTGGGTATCGGGCAGCAGTCACTGGGGCTCAAGGGCA
GTGAGCAAGAGAAATGTCTAAAGCTGCTTCTCCCAACACCGTCCAAAGTCTCCACTGCCTGAGTTTTGTTTCGGCTGGTTTGAACTCATTTCGGGTGTGT
GCATTTTTCTTTTGGTACCCATGTGAGACATGAACAACAGGAGGGAGGGAAAGAGCCCAGGTGGGACGTGGGACAGGCTTAGGGGAAAGAGCTTGTCCTA
TCTCAGGAACAAAATTATAGGCTGTGGGCAGAGGGTCTGAAAGGTGGGCTTTGGGGTAGTGCCCAAGCCTGGTCGTGTTGCCAGGAGTGGTGACAAGAAA
TGCAGCTTACATCAAACGAACATGTAGTGCATGCCCACTGCCTGATGGCCAGATGGCCTGTAGGAAGAGCTACCAGGGCTTCCAGACCTGTGGAACGAAG
AGGATGGGGAAAAGGCAGAGGGCACTGAGTGTCCCTTTAAAAACTAACCCACTGAATATTCCGTGTGATCTAGAACAGTGTGGCAGCTTTCACAGCACAG
GACCGTTCATCGGGGGCCTAAACGTTTCCCTCAGCTCTGTCACCAACTCACTTCTCTCGGCTTCGTTGTCTGTAAATTGGATGAAAAGAGCTCTAATGCC
TTTCAGGCTCTTAGAAGCCATAGATTTGGACAAGCCCAGCAAGATGGGTGTCCTTCCAGGCCTCTTCCCCTTTCCTCCATCTCTGGCAACAGTTCTTGGG
GTTTGGCAATTGTTTGGATTTTTTTTCTTTCTGCAGTTGTGTGTATGTGTGTTTGTGTGAAGAAAAACAGACTCTGTCCAGGTAGAAATGGTGAGGAGGG
GGAAGAGAATTACATTTCCAGGGTCAGAAACTTGGCAACAGTTTTCCTAGAGTGACTCAGACACACCACAGTAACAACTCTCGCTGCAATTTTATTTTAA
TTTGAGAAATAAAGATTTCCTCCAAGCCACATGAGGACTCTGGCACCCACCCACAAAGCAAGACCTGTATTTATAAGCCGAGGGCTCAGGGAGCCTAACT
GCGGGACCCGTCAGGGCCCCGTGACCCATCCCCGTCCCCACCCCCCCCTCCACCGCTGGGCCCATCAGTGTGTGTTGGGGGGATGCTTGGCAGCTGGGGG
TGAGGAGACAACAAACCTCGGGAACTGGAGCCAGAGCTGCGGCCTGACTGACGCCTTTTGATGCTCACGGGAAATTTCTGCCCAGGATCTCAGCCCCAGG
CTGGTTGTTTCTACAAATCTCTCTCAAATGTATTATTTTGGTGACAAAAATGAAGGAGCTTTGTAAATTTTTTTTAAAATTATGAATCATATCAAGTAGT
TGTTTACATTTCTTGAAAAAATAGGAACTCGGGCAGCAGAATCAGATTGGCAGAATCTTTAGACTACACAGGCAATAATCAAGTCTGCTGTTTTGGCCTT
TCGTAGTAGAAGTGGTTGTAGTGTTTAGATATCTGTTTGGTCTTGCTTCTTGTATTGCATTTTTTTCAATAAACAACAACAAAAAGAACTCTCTCTGTGA
GGATTGATCCACTTTTAAATTTCTCTTCTACCAGCAACTTGGGAAAAATTAAATATGGGTGGGGGAGACCTAAACTCAAGTCATTTTCTAAAGTAAGTTA
CCCACATTGACCAAAATGCAGCTTCAACGTTGAGTAAAGGGATTTCTGAGAGCTGGCCAATGCCTTTTGCCAGCTGCAGTGAGATTCTGCAGCATAGGCC
ACGATAAAGGAAGGAGAGAAGGGGCTTCTCAGACTTATTTGCAGAAGGGCCCAGAACTCAGTATGAAGGCATTGGCAGTAGTGTAGCTCTAGAGGGATAT
ACCCCAGATGGCTGAGGGAAGAAAGGGATTGAGGTGGTAGGAGTTCAAGGCTCAGTCCCCGTCCCAGATGGCAGTGGAGAGTCTCATCCCGTG
  • refseq_EPB41.F1 (forward primer)
  • refseq_EPB41.R1 (reverse primer)
  • Single exon skipping

Frame 0

APAGQSGRNLLKGESGAEPERGRPGPRRTQPRE
EFSD*GRKFTAPTEGRG*GSHKLRPTRTSAGGIL
SNSS*RR*LV*TEAESF*WRHSYT*RLDQEQGA
DIRKQRTFTTILLVSQKAQISGVRGRRQRSRVR
*RKR*RRSERDRIWNQS**RDHFKGPNCSS*TGT
QNRPIFGSSFIKQCRNTASPLQLRIIFRVFLFL
KHVNIICIVKSPAQEELREDPDFEIKEGEGLEE
CSKIEVKEESPQSKAETELKASQKPIRKHRNMHC
KVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNL
LEEDYFGLAIWDNATSKTWLDSAKEIKKQVRGV
PWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQD
IVAGRLPCSFATLALLGSYTIQSELGDYDPELH
GVDYVSDFKLAPNQTKELEEKVMELHKSYRSMT
PAQADLEFLENAKKLSMYGVDLHKAKDLEGVDII
LGVCSSGLLVYKDKLRINRFPWPKVLKISYKRS
SFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWK
VCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGR
TQAQTRQASALIDRPAPHFERTASKRASRSLDG
AAAVDSADRSPRPTSAPAITQGQVAEGGVLDAS
AKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTE
AWKKKRERLDGENIYIRHSNLMLEDLDKSQEEI
KKHHASISELKKNFMESVPEPRPSEWDKRLSTH
SPFRTLNINGQIPTGEGPPLVKTQTVTISDNANA
VKSEIPTKDVPIVHTETKTITYEAAQTVKGGIS
ETRIEKRIVITGDADIDHDQVLVQAIKEAKEQH
PDMSVTKVVVHQETEIADE*AQELTYPNSALLPS
KRNQQNDKEANLP*SDFRLSRLF*ITRKLISVS
IGSLYQEILLDLIDPFEELFLY*DIRIVQLFTL
*TVLRVLGFF*LGGL*PLQPSLSAHLFPTPTDTD
RVHGILREILQGLLSAVLEAKASLVGLPRLSLV
LSPLDDGRNFMNQPFLRASDVSVSECQGGHQP*
STDLGKMPLFLCCGWFW*GRALC*ECSIVFPLSL
LLSFWSFFGSKTWKLLQISDTVNV*TYPWPSPL
QLPFYLIRSSGSAKCSP*LPSQETKSHRKIGTL
GQKL*WNIFSGDLGKES**GF*NKVF*F*ECALH
TGEWGYFCLILGLSFIPNDKECGSEKGFSFLTF
LLSTGTCLRTPF*SKELTFRSRSPHKTPHDKGY
KPQPCSFPLTS*GLSGFEGLILWWVWGLVFLFFI
LIFESEDDALIPGKDLGHSFLFF*DGVSLLLPK
LECSGAISAHCNLRLLGSSSSLASASQVAGMTG
AHHHAQQIFCIFSRNGISPC*AGLELLTSGDPPT
LASQSAGITGVSHHARPIWGIFI*QNFSNLPTA
SHKHIGLKAP*NPSSSFLK*TVGIGQQSLGLKG
SEQEKCLKLLLPTPSKVSTA*VLFRLV*THFGCV
HFSFGTHVRHEQQEGGKEPRWDVGQA*GKELVL
SQEQNYRLWAEGLKGGLWGSAQAWSCCQEW*QE
MQLTSNEHVVHAHCLMARWPVGRATRASRPVERR
GWGKGRGH*VSL*KLTH*IFRVI*NSVAAFTAQ
DRSSGA*TFPSALSPTHFSRLRCL*IG*KEL*C
LSGS*KP*IWTSPARWVSFQASSPFLHLWQQFLG
FGNCLDFFSFCSCVYVCLCEEKQTLSR*KW*GG
GRELHFQGQKLGNSFPRVTQTHHSNNSRCNFIL
I*EIKISSKPHEDSGTHPQSKTCIYKPRAQGA*L
RDPSGPRDPSPSPPPPPPLGPSVCVGGMLGSWG
*GDNKPRELEPELRPD*RLLMLTGNFCPGSQPQ
AGCFYKSLSNVLFW*QK*RSFVNFF*NYESYQVV
VYIS*KNRNSGSRIRLAESLDYTGNNQVCCFGL
S**KWL*CLDICLVLLLVLHFFQ*TTTKRTLSV
RIDPLLNFSSTSNLGKIKYGWGRPKLKSFSKVSY
PH*PKCSFNVE*RDF*ELANAFCQLQ*DSAA*A
TIKEGEKGLLRLICRRAQNSV*RHWQ*CSSRGI
YPRWLREERD*GGRSSRLSPRPRWQWRVSSR

Frame 1

PRRGKVAGTS*RARAARSQNAVGPVPAAPSPEK
SLVTEAENSQHQQKEEGEEAINSGQQEPQQEES
CQTAAEGDNWCEQKLKASNGDTPTHEDLTKNKER
TSESRGLSRLFSSFLKRPKSQVSEEEGKEVESD
KEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPE
LKTDPSLDLHSLSSAETQPHHYN*ELFSESSYF*
SM*ILSASLKVLLRKNSEKIQILKLRKEKDLKS
APK*K*KKKALNQKQKQN*KLPKNQSENTGTCT
ARFLCWMTQFMNVLWRNMLRDKICLNEYVSISIF
WKKTILV*PFGITQPLRHGWIPPKK*KSRFVVS
LGILHLM*SFIHLTQHS*QKT*QDIIYVFSFGR
T*LQDVCPVPLQP*HY*VLTPSSLNWETTTQNSM
AWIMLVILNWPRIRPRNLKRRSWNCISHTGP*L
QLRLTWSFLRMPKSCLCMELIFIKQRTWKE*IS
S*VSALVAFWFTKIS*ELTASLGPKC*RFLINVV
AFSSRFGLESKSSMKVPSDSNFPVTEQLRNYGK
SV*NITRFSD*HLQTPFPKANFLR*DPNFDTVA
GLKLRPGKLVL*LTGLPHTSSVQQVNGRPGASME
QQLSIRQTEVLGPLLHLPLLRVRLQKVAS*MPL
LKKQWSLKHRRKQ*RLK*KRKTSHLSKLSQSPQ
KHGRKREKD*MVKTFISDIAI*CWRI*TRVKRRS
KNIMPASVS*KRTSWSLYQNHGLVNGINAYPLT
HPSELLTSMGKSPQEKDLPW*RHKLSPSQIMPM
L*KVKSQPKTSLLSTLRPRPSLMRLPRL*KVGFQ
RHVLKREL*SQEMLILTMIRSLYKPSRRQRSST
QTCQ*PRWSSTRRPRLLMSELRN*PTPTLPFSH
PRETSKMIKKLTCHSQTSDFQDYSKSPEN*FQFL
LGVYTKRFF*ISLILLKSFFYIRISELFNFSLY
RLF*EFWGFFNWVVCNPFSLASLPIYFQPQQTL
TGSMEFFGKSSKDSCQLCWKPKPA*WDFRVSP*S
YPLWMMAETS*TSPFSEPVM*VYQNAREGTSPD
PQTSERCPCSFVAGGFGKAEPSAENVVLFFPSP
SCFLFGASLGQRHGSCFRYLIL*MFEHIRGLHLS
SYPFTSSEAVAQLSAPPSSHLRRPNLTEK*ALW
AKSSNGTFLVVIWGRKVNEVFKIRFSSFESVHF
TQGNGVTSV*SWAFLSSQMTRNVAQRRVFLF*PF
FSQQEPA*GHPSRARN*LLGAVLPTRHHMTRGI
SPSPAHSHSPAEVCQVLKA*FCGGFGA*FSFFS
F*FLKVKMMP*FLVRIWGIVFCFFETEFRSCCPS
WSAVARSRLTATSASWVQAVLLPQPPK*LG*QA
HTTTPSKFFVFLVETGFHLVRLVSNS*PQVIHP
PWPPKVLGLQV*ATTPGRFGAFLFNRTSLTFQLL
PTNTLASRLLRIPVPAS*NRQWVSGSSHWGSRA
VSKRNV*SCFSQHRPKSPLPEFCFGWFELISGV
CIFLLVPM*DMNNRREGKSPGGTWDRLRGKSLSY
LRNKIIGCGQRV*KVGFGVVPKPGRVARSGDKK
CSLHQTNM*CMPTA*WPDGL*EELPGLPDLWNE
EDGEKAEGTECPFKN*PTEYSV*SRTVWQLSQHR
TVHRGPKRFPQLCHQLTSLGFVVCKLDEKSSNA
FQALRSHRFGQAQQDGCPSRPLPLSSISGNSSW
GLAIVWIFFLSAVVCMCVCVKKNRLCPGRNGEEG
EENYISRVRNLATVFLE*LRHTTVTTLAAILF*
FEK*RFPPSHMRTLAPTHKARPVFISRGLREPN
CGTRQGPVTHPRPHPPLHRWAHQCVLGGCLAAGG
EETTNLGNWSQSCGLTDAF*CSREISAQDLSPR
LVVSTNLSQMYYFGDKNEGAL*IFFKIMNHIK*
LFTFLEKIGTRAAESDWQNL*TTQAIIKSAVLAF
RSRSGCSV*ISVWSCFLYCIFFNKQQQKELSL*
GLIHF*ISLLPATWEKLNMGGGDLNSSHFLK*V
THIDQNAASTLSKGISESWPMPFASCSEILQHRP
R*RKERRGFSDLFAEGPRTQYEGIGSSVALEGY
TPDG*GKKGIEVVGVQGSVPVPDGSGESHPV

Frame 2

PGGAKWQEPLKGRERRGARTRSARSPPHPAQRR
V**LRPKIHSTNRRKRVRKP*TQANKNLSRRNL
VKQQLKEIIGVNRS*KLLMETLLHMKT*PRTRS
GHQKAEDFHDYSPRFSKGPNLRCPRKKAKK*SQI
KKKVKEVRKR*NLEPVLMKRSF*RPQLQLLNRN
SKQTHLWIFIH*AVQKHSLTITIKNYFQSLLIS
EACEYYLHR*KSCSGRTQRRSRF*N*GRRRT*RV
LQNRSKRRKPSIKSRNRIKSFPKTNQKTQEHAL
QGFFVG*HSL*MCCGETC*GTRFA*TSM*ASQS
FGRRLFWSSHLG*RNL*DMAGFRQRNKKAGSWCP
LEFYI*CKVLST*PSTVNRRHNKILFMSSASAG
HSCRTSALFLCNLSIIRFLHHPV*TGRLRPRTP
WRGLC**F*TGPESDQGT*REGHGTA*VIQVHDS
SSG*LGVS*ECQKVVYVWS*SS*SKGLGRSRYH
PRCLL*WPSGLQR*AEN*PLPLAQSAEDFL*T*
*LFHQDSAWRARAV*KYHRIQTSQLPSS*EIMES
LCRTSHVFQIDIYRHHSQKQISCARIQISIQWP
DSSSDQAS*CSN*QACPTLRAYSK*TGVPEPRW
SSSCRFGRPKSSAHFCTCHYSGSGCRRWRPRCLC
*KNSGP*STEGNSEG*SEKGRRAT*AS*ARAHR
SMEEKERKTRW*KHLYQT*QFNVGGFRQESRGD
QKTSCQHQ*AEKELHGVCTRTTA**MG*TLIHSL
TLPNS*HQWANPHRRRTSPGEDTNCHHLR*CQC
CEK*NPNQRRPYCPH*DQDHHL*GCPDCKRWDF
RDTY*KENCDHRRC*Y*P*SGPCTSHQGGKGAAP
RHVSDQGGRPPGDRDC**VSSGTNLPQLCPSPI
QEKPAK**RS*PAIVRLQTFKIILNHQKINFSF
YWEFIPRDSSRSH*SF*RAFSILGYQNCSTFHSI
DCFKSFGVFLIGWFVTPSA*PLCPFISNPNRH*
QGPWNSSGNPPRTLVSCVGSQSQLSGTSASLPS
LIPFG*WQKLHEPALSQSQ*CECIRMPGRAPALI
HRPRKDAPVPLLRVVLVRQSPLLRM*YCFSPLP
PAFFLELLWVKDMEVASDI*YCECLNISVAFTS
PATLLPHQKQWLS*VLPLAPISGDQISQKNRHFG
PKALMEHF*W*FGEGKLMRFLK*GFLVLRVCTS
HRGMGLLLSDPGPFFHPK*QGMWLREGFFFFDL
SSLNRNLPEDTLLEQGIDF*EPFSPQDTT*QGV*
APALLIPTHQLRSVRF*RLDFVVGLGLSFPFFH
FDF*K*R*CPNSW*GFGA*FFVFLRRSFALVAQ
AGVQWRDLGSLQPPPPGFKQFSCLSLPSSWDDRR
TPPRPANFLYF**KRDFTLLGWSRTPDLR*STH
LGLPKCWDYRCEPPRPADLGHFYLTELL*PSNC
FPQTHWPQGSLESQFQLPKIDSGYRAAVTGAQGQ
*AREMSKAASPNTVQSLHCLSFVSAGLNSFRVC
AFFFWYPCET*TTGGRERAQVGRGTGLGERACP
ISGTKL*AVGRGSERWALG*CPSLVVLPGVVTRN
AAYIKRTCSACPLPDGQMACRKSYQGFQTCGTK
RMGKRQRALSVPLKTNPLNIPCDLEQCGSFHST
GPFIGGLNVSLSSVTNSLLSASLSVNWMKRALMP
FRLLEAIDLDKPSKMGVLPGLFPFPPSLATVLG
VWQLFGFFFFLQLCVCVFV*RKTDSVQVEMVRR
GKRITFPGSETWQQFS*SDSDTPQ*QLSLQFYFN
LRNKDFLQAT*GLWHPPTKQDLYL*AEGSGSLT
AGPVRAP*PIPVPTPPSTAGPISVCWGDAWQLG
VRRQQTSGTGARAAA*LTPFDAHGKFLPRISAPG
WLFLQISLKCIILVTKMKELCKFFLKL*IISSS
CLHFLKK*ELGQQNQIGRIFRLHRQ*SSLLFWP
FVVEVVVVFRYLFGLASCIAFFSINNNKKNSLCE
D*STFKFLFYQQLGKN*IWVGET*TQVIF*SKL
PTLTKMQLQR*VKGFLRAGQCLLPAAVRFCSIG
HDKGRREGASQTYLQKGPELSMKALAVV*L*RDI
PQMAEGRKGLRW*EFKAQSPSQMAVESLIP

Sequence NM_203342

GCCCCGGCGGGGCAAAGTGGCAGGAACCTCTTAAAGGGCGAGAGCGGCGCGGAGCCAGAACGCGGTCGGCCCGGTCCCCGCCGCACCCAGCCCAGCAACA
TCATGACAACAGAGAAGAGTTTAGTGACTGAGGCCGAAAATTCACAGCACCAACAGAAGGAAGAGGGTGAGGAAGCCATAAACTCAGGCCAACAAGAACC
TCAGCAGGAGGAATCTTGTCAAACAGCAGCTGAAGGAGATAATTGGTGTGAACAGAAGCTGAAAGCTTCTAATGGAGACACTCCTACACATGAAGACTTG
ACCAAGAACAAGGAGCGGACATCAGAAAGCAGAGGACTTTCACGACTATTCTCCTCGTTTCTCAAAAGGCCCAAATCTCAGGTGTCCGAGGAAGAAGGCA
AAGAAGTAGAGTCAGATAAAGAAAAAGGTGAAGGAGGTCAGAAAGAGATAGAATTTGGAACCAGTCTTGATGAAGAGATCATTTTAAAGGCCCCAATTGC
AGCTCCTGAACCGGAACTCAAAACAGACCCATCTTTGGATCTTCATTCATTAAGCAGTGCAGAAACACAGCCTCACCATTACAATTAAGAATTATTTTCA
GAGTCTTCTTATTTCTGAAGCATGTGAATATTATCTGCATCGTTAAAAGTCCTGCTCAGGAAGAACTCAGAGAAGATCCAGATTTTGAAATTAAGGAAGG
AGAAGGACTTGAAGAGTGCTCCAAAATAGAAGTAAAAGAAGAAAGCCCTCAATCAAAAGCAGAAACAGAATTAAAAGCTTCCCAAAAACCAATCAGAAAA
CACAGGAACATGCACTGCAAGGTTTCTTTGTTGGATGACACAGTTTATGAATGTGTTGTGGAGAAACATGCTAAGGGACAAGATTTGCTTAAACGAGTAT
GTGAGCATCTCAATCTTTTGGAAGAAGACTATTTTGGTCTAGCCATTTGGGATAACGCAACCTCTAAGACATGGCTGGATTCCGCCAAAGAAATAAAAAA
GCAGGTTCGTGGTGTCCCTTGGAATTTTACATTTAATGTAAAGTTTTATCCACCTGACCCAGCACAGTTAACAGAAGACATAACAAGATATTATTTATGT
CTTCAGCTTCGGCAGGACATAGTTGCAGGACGTCTGCCCTGTTCCTTTGCAACCTTAGCATTATTAGGTTCTTACACCATCCAGTCTGAACTGGGAGACT
ACGACCCAGAACTCCATGGCGTGGATTATGTTAGTGATTTTAAACTGGCCCCGAATCAGACCAAGGAACTTGAAGAGAAGGTCATGGAACTGCATAAGTC
ATACAGGTCCATGACTCCAGCTCAGGCTGACTTGGAGTTTCTTGAGAATGCCAAAAAGTTGTCTATGTATGGAGTTGATCTTCATAAAGCAAAGGACTTG
GAAGGAGTAGATATCATCCTAGGTGTCTGCTCTAGTGGCCTTCTGGTTTACAAAGATAAGCTGAGAATTAACCGCTTCCCTTGGCCCAAAGTGCTGAAGA
TTTCTTATAAACGTAGTAGCTTTTTCATCAAGATTCGGCCTGGAGAGCAAGAGCAGTATGAAAGTACCATCGGATTCAAACTTCCCAGTTACCGAGCAGC
TAAGAAATTATGGAAAGTCTGTGTAGAACATCACACGTTTTTCAGATTGACATCTACAGACACCATTCCCAAAAGCAAATTTCTTGCGCTAGGATCCAAA
TTTCGATACAGTGGCCGGACTCAAGCTCAGACCAGGCAAGCTAGTGCTCTAATTGACAGGCCTGCCCCACACTTCGAGCGTACAGCAAGTAAACGGGCGT
CCCGGAGCCTCGATGGAGCAGCAGCTGTCGATTCGGCAGACCGAAGTCCTCGGCCCACTTCTGCACCTGCCATTACTCAGGGTCAGGTTGCAGAAGGTGG
CGTCCTAGATGCCTCTGCTAAAAAAACAGTGGTCCCTAAAGCACAGAAGGAAACAGTGAAGGCTGAAGTGAAAAAGGAAGACGAGCCACCTGAGCAAGCT
GAGCCAGAGCCCACAGAAGCATGGAAGGTGGAAAAAACCCACATCGAGGTGACAGTACCCACCTCAAATGGTGACCAAACACAGAAAAAGAGAGAAAGAC
TAGATGGTGAAAACATTTATATCAGACATAGCAATTTAATGTTGGAGGATTTAGACAAGAGTCAAGAGGAGATCAAAAAACATCATGCCAGCATCAGTGA
GCTGAAAAAGAACTTCATGGAGTCTGTACCAGAACCACGGCCTAGTGAATGGGATAAACGCTTATCCACTCACTCACCCTTCCGAACTCTTAACATCAAT
GGGCAAATCCCCACAGGAGAAGGACCTCCCCTGGTGAAGACACAAACTGTCACCATCTCAGATAATGCCAATGCTGTGAAAAGTGAAATCCCAACCAAAG
ACGTCCCTATTGTCCACACTGAGACCAAGACCATCACTTATGAGGCTGCCCAGACTGACGACAACAGTGGAGACTTGGACCCAGGAGTCTTGCTGACAGC
TCAAACTATCACATCTGAGACCCCAAGCAGCACCACCACAACTCAAATTACCAAGACTGTAAAAGGTGGGATTTCAGAGACACGTATTGAAAAGAGAATT
GTGATCACAGGAGATGCTGATATTGACCATGATCAGGTCCTTGTACAAGCCATCAAGGAGGCAAAGGAGCAGCACCCAGACATGTCAGTGACCAAGGTGG
TCGTCCACCAGGAGACCGAGATTGCTGATGAGTGAGCTCAGGAACTAACCTACCCCAACTCTGCCCTTCTCCCATCCAAGAGAAACCAGCAAAATGATAA
AGAAGCTAACCTGCCATAGTCAGACTTCAGACTTTCAAGATTATTCTAAATCACCAGAAAATTAATTTCAGTTTCTATTGGGAGTTTATACCAAGAGATT
CTTCTAGATCTCATTGATCCTTTTGAAGAGCTTTTTCTATATTAGGATATCAGAATTGTTCAACTTTTCACTCTATAGACTGTTTTAAGAGTTTTGGGGT
TTTTTTAATTGGGTGGTTTGTAACCCCTTCAGCCTAGCCTCTCTGCCCATTTATTTCCAACCCCAACAGACACTGACAGGGTCCATGGAATTCTTCGGGA
AATCCTCCAAGGACTCTTGTCAGCTGTGTTGGAAGCCAAAGCCAGCTTAGTGGGACTTCCGCGTCTCTCCCTAGTCTTATCCCCTTTGGATGATGGCAGA
AACTTCATGAACCAGCCCTTTCTCAGAGCCAGTGATGTGAGTGTATCAGAATGCCAGGGAGGGCACCAGCCCTGATCCACAGACCTCGGAAAGATGCCCC
TGTTCCTTTGTTGCGGGTGGTTTTGGTAAGGCAGAGCCCTCTGCTGAGAATGTAGTATTGTTTTTCCCCTCTCCCTCCTGCTTTCTTTTTGGAGCTTCTT
TGGGTCAAAGACATGGAAGTTGCTTCAGATATCTGATACTGTGAATGTTTGAACATATCCGTGGCCTTCACCTCTCCAGCTACCCTTTTACCTCATCAGA
AGCAGTGGCTCAGCTAAGTGCTCCCCCTAGCTCCCATCTCAGGAGACCAAATCTCACAGAAAAATAGGCACTTTGGGCCAAAAGCTCTAATGGAACATTT
TTAGTGGTGATTTGGGGAAGGAAAGTTAATGAGGTTTTTAAAATAAGGTTTTCTAGTTTTGAGAGTGTGCACTTCACACAGGGGAATGGGGTTACTTCTG
TCTGATCCTGGGCCTTTCTTTCATCCCAAATGACAAGGAATGTGGCTCAGAGAAGGGTTTTTCTTTTTTGACCTTTCTTCTCTCAACAGGAACCTGCCTG
AGGACACCCTTCTAGAGCAAGGAATTGACTTTTAGGAGCCGTTCTCCCCACAAGACACCACATGACAAGGGGTATAAGCCCCAGCCCTGCTCATTCCCAC
TCACCAGCTGAGGTCTGTCAGGTTTTGAAGGCTTGATTTTGTGGTGGGTTTGGGGCTTAGTTTTCCTTTTTTTCATTTTGATTTTTGAAAGTGAAGATGA
TGCCCTAATTCCTGGTAAGGATTTGGGGCATAGTTTTTTGTTTTTTTGAGACGGAGTTTCGCTCTTGTTGCCCAAGCTGGAGTGCAGTGGCGCGATCTCG
GCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCAGTTCTCTTGCCTCAGCCTCCCAAGTAGCTGGGATGACAGGCGCACACCACCACGCCCAGCAAATTT
TTTGTATTTTTAGTAGAAACGGGATTTCACCTTGTTAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGAT
TACAGGTGTGAGCCACCACGCCCGGCCGATTTGGGGCATTTTTATTTAACAGAACTTCTCTAACCTTCCAACTGCTTCCCACAAACACATTGGCCTCAAG
GCTCCTTAGAATCCCAGTTCCAGCTTCCTAAAATAGACAGTGGGTATCGGGCAGCAGTCACTGGGGCTCAAGGGCAGTGAGCAAGAGAAATGTCTAAAGC
TGCTTCTCCCAACACCGTCCAAAGTCTCCACTGCCTGAGTTTTGTTTCGGCTGGTTTGAACTCATTTCGGGTGTGTGCATTTTTCTTTTGGTACCCATGT
GAGACATGAACAACAGGAGGGAGGGAAAGAGCCCAGGTGGGACGTGGGACAGGCTTAGGGGAAAGAGCTTGTCCTATCTCAGGAACAAAATTATAGGCTG
TGGGCAGAGGGTCTGAAAGGTGGGCTTTGGGGTAGTGCCCAAGCCTGGTCGTGTTGCCAGGAGTGGTGACAAGAAATGCAGCTTACATCAAACGAACATG
TAGTGCATGCCCACTGCCTGATGGCCAGATGGCCTGTAGGAAGAGCTACCAGGGCTTCCAGACCTGTGGAACGAAGAGGATGGGGAAAAGGCAGAGGGCA
CTGAGTGTCCCTTTAAAAACTAACCCACTGAATATTCCGTGTGATCTAGAACAGTGTGGCAGCTTTCACAGCACAGGACCGTTCATCGGGGGCCTAAACG
TTTCCCTCAGCTCTGTCACCAACTCACTTCTCTCGGCTTCGTTGTCTGTAAATTGGATGAAAAGAGCTCTAATGCCTTTCAGGCTCTTAGAAGCCATAGA
TTTGGACAAGCCCAGCAAGATGGGTGTCCTTCCAGGCCTCTTCCCCTTTCCTCCATCTCTGGCAACAGTTCTTGGGGTTTGGCAATTGTTTGGATTTTTT
TTCTTTCTGCAGTTGTGTGTATGTGTGTTTGTGTGAAGAAAAACAGACTCTGTCCAGGTAGAAATGGTGAGGAGGGGGAAGAGAATTACATTTCCAGGGT
CAGAAACTTGGCAACAGTTTTCCTAGAGTGACTCAGACACACCACAGTAACAACTCTCGCTGCAATTTTATTTTAATTTGAGAAATAAAGATTTCCTCCA
AGCCACATGAGGACTCTGGCACCCACCCACAAAGCAAGACCTGTATTTATAAGCCGAGGGCTCAGGGAGCCTAACTGCGGGACCCGTCAGGGCCCCGTGA
CCCATCCCCGTCCCCACCCCCCCCTCCACCGCTGGGCCCATCAGTGTGTGTTGGGGGGATGCTTGGCAGCTGGGGGTGAGGAGACAACAAACCTCGGGAA
CTGGAGCCAGAGCTGCGGCCTGACTGACGCCTTTTGATGCTCACGGGAAATTTCTGCCCAGGATCTCAGCCCCAGGCTGGTTGTTTCTACAAATCTCTCT
CAAATGTATTATTTTGGTGACAAAAATGAAGGAGCTTTGTAAATTTTTTTTAAAATTATGAATCATATCAAGTAGTTGTTTACATTTCTTGAAAAAATAG
GAACTCGGGCAGCAGAATCAGATTGGCAGAATCTTTAGACTACACAGGCAATAATCAAGTCTGCTGTTTTGGCCTTTCGTAGTAGAAGTGGTTGTAGTGT
TTAGATATCTGTTTGGTCTTGCTTCTTGTATTGCATTTTTTTCAATAAACAACAACAAAAAGAACTCTCTCTGTGAGGATTGATCCACTTTTAAATTTCT
CTTCTACCAGCAACTTGGGAAAAATTAAATATGGGTGGGGGAGACCTAAACTCAAGTCATTTTCTAAAGTAAGTTACCCACATTGACCAAAATGCAGCTT
CAACGTTGAGTAAAGGGATTTCTGAGAGCTGGCCAATGCCTTTTGCCAGCTGCAGTGAGATTCTGCAGCATAGGCCACGATAAAGGAAGGAGAGAAGGGG
CTTCTCAGACTTATTTGCAGAAGGGCCCAGAACTCAGTATGAAGGCATTGGCAGTAGTGTAGCTCTAGAGGGATATACCCCAGATGGCTGAGGGAAGAAA
GGGATTGAGGTGGTAGGAGTTCAAGGCTCAGTCCCCGTCCCAGATGGCAGTGGAGAGTCTCATCCCGTG
  • refseq_EPB41.F1 (forward primer)
  • refseq_EPB41.R1 (reverse primer)
  • Single exon skipping

Frame 0

APAGQSGRNLLKGESGAEPERGRPGPRRTQPSN
IMTTEKSLVTEAENSQHQQKEEGEEAINSGQQEP
QQEESCQTAAEGDNWCEQKLKASNGDTPTHEDL
TKNKERTSESRGLSRLFSSFLKRPKSQVSEEEG
KEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIA
APEPELKTDPSLDLHSLSSAETQPHHYN*ELFS
ESSYF*SM*ILSASLKVLLRKNSEKIQILKLRK
EKDLKSAPK*K*KKKALNQKQKQN*KLPKNQSEN
TGTCTARFLCWMTQFMNVLWRNMLRDKICLNEY
VSISIFWKKTILV*PFGITQPLRHGWIPPKK*K
SRFVVSLGILHLM*SFIHLTQHS*QKT*QDIIYV
FSFGRT*LQDVCPVPLQP*HY*VLTPSSLNWET
TTQNSMAWIMLVILNWPRIRPRNLKRRSWNCIS
HTGP*LQLRLTWSFLRMPKSCLCMELIFIKQRTW
KE*ISS*VSALVAFWFTKIS*ELTASLGPKC*R
FLINVVAFSSRFGLESKSSMKVPSDSNFPVTEQ
LRNYGKSV*NITRFSD*HLQTPFPKANFLR*DPN
FDTVAGLKLRPGKLVL*LTGLPHTSSVQQVNGR
PGASMEQQLSIRQTEVLGPLLHLPLLRVRLQKV
AS*MPLLKKQWSLKHRRKQ*RLK*KRKTSHLSKL
SQSPQKHGRWKKPTSR*QYPPQMVTKHRKREKD
*MVKTFISDIAI*CWRI*TRVKRRSKNIMPASV
S*KRTSWSLYQNHGLVNGINAYPLTHPSELLTSM
GKSPQEKDLPW*RHKLSPSQIMPML*KVKSQPK
TSLLSTLRPRPSLMRLPRLTTTVETWTQESC*Q
LKLSHLRPQAAPPQLKLPRL*KVGFQRHVLKREL
*SQEMLILTMIRSLYKPSRRQRSSTQTCQ*PRW
SSTRRPRLLMSELRN*PTPTLPFSHPRETSKMI
KKLTCHSQTSDFQDYSKSPEN*FQFLLGVYTKRF
F*ISLILLKSFFYIRISELFNFSLYRLF*EFWG
FFNWVVCNPFSLASLPIYFQPQQTLTGSMEFFG
KSSKDSCQLCWKPKPA*WDFRVSP*SYPLWMMAE
TS*TSPFSEPVM*VYQNAREGTSPDPQTSERCP
CSFVAGGFGKAEPSAENVVLFFPSPSCFLFGAS
LGQRHGSCFRYLIL*MFEHIRGLHLSSYPFTSSE
AVAQLSAPPSSHLRRPNLTEK*ALWAKSSNGTF
LVVIWGRKVNEVFKIRFSSFESVHFTQGNGVTS
V*SWAFLSSQMTRNVAQRRVFLF*PFFSQQEPA*
GHPSRARN*LLGAVLPTRHHMTRGISPSPAHSH
SPAEVCQVLKA*FCGGFGA*FSFFSF*FLKVKM
MP*FLVRIWGIVFCFFETEFRSCCPSWSAVARSR
LTATSASWVQAVLLPQPPK*LG*QAHTTTPSKF
FVFLVETGFHLVRLVSNS*PQVIHPPWPPKVLG
LQV*ATTPGRFGAFLFNRTSLTFQLLPTNTLASR
LLRIPVPAS*NRQWVSGSSHWGSRAVSKRNV*S
CFSQHRPKSPLPEFCFGWFELISGVCIFLLVPM
*DMNNRREGKSPGGTWDRLRGKSLSYLRNKIIGC
GQRV*KVGFGVVPKPGRVARSGDKKCSLHQTNM
*CMPTA*WPDGL*EELPGLPDLWNEEDGEKAEG
TECPFKN*PTEYSV*SRTVWQLSQHRTVHRGPKR
FPQLCHQLTSLGFVVCKLDEKSSNAFQALRSHR
FGQAQQDGCPSRPLPLSSISGNSSWGLAIVWIF
FLSAVVCMCVCVKKNRLCPGRNGEEGEENYISRV
RNLATVFLE*LRHTTVTTLAAILF*FEK*RFPP
SHMRTLAPTHKARPVFISRGLREPNCGTRQGPV
THPRPHPPLHRWAHQCVLGGCLAAGGEETTNLGN
WSQSCGLTDAF*CSREISAQDLSPRLVVSTNLS
QMYYFGDKNEGAL*IFFKIMNHIK*LFTFLEKI
GTRAAESDWQNL*TTQAIIKSAVLAFRSRSGCSV
*ISVWSCFLYCIFFNKQQQKELSL*GLIHF*IS
LLPATWEKLNMGGGDLNSSHFLK*VTHIDQNAA
STLSKGISESWPMPFASCSEILQHRPR*RKERRG
FSDLFAEGPRTQYEGIGSSVALEGYTPDG*GKK
GIEVVGVQGSVPVPDGSGESHPV

Frame 1

PRRGKVAGTS*RARAARSQNAVGPVPAAPSPAT
S*QQRRV**LRPKIHSTNRRKRVRKP*TQANKN
LSRRNLVKQQLKEIIGVNRS*KLLMETLLHMKT*
PRTRSGHQKAEDFHDYSPRFSKGPNLRCPRKKA
KK*SQIKKKVKEVRKR*NLEPVLMKRSF*RPQL
QLLNRNSKQTHLWIFIH*AVQKHSLTITIKNYFQ
SLLISEACEYYLHR*KSCSGRTQRRSRF*N*GR
RRT*RVLQNRSKRRKPSIKSRNRIKSFPKTNQK
TQEHALQGFFVG*HSL*MCCGETC*GTRFA*TSM
*ASQSFGRRLFWSSHLG*RNL*DMAGFRQRNKK
AGSWCPLEFYI*CKVLST*PSTVNRRHNKILFM
SSASAGHSCRTSALFLCNLSIIRFLHHPV*TGRL
RPRTPWRGLC**F*TGPESDQGT*REGHGTA*V
IQVHDSSSG*LGVS*ECQKVVYVWS*SS*SKGL
GRSRYHPRCLL*WPSGLQR*AEN*PLPLAQSAED
FL*T**LFHQDSAWRARAV*KYHRIQTSQLPSS
*EIMESLCRTSHVFQIDIYRHHSQKQISCARIQ
ISIQWPDSSSDQAS*CSN*QACPTLRAYSK*TGV
PEPRWSSSCRFGRPKSSAHFCTCHYSGSGCRRW
RPRCLC*KNSGP*STEGNSEG*SEKGRRAT*AS
*ARAHRSMEGGKNPHRGDSTHLKW*PNTEKERKT
RW*KHLYQT*QFNVGGFRQESRGDQKTSCQHQ*
AEKELHGVCTRTTA**MG*TLIHSLTLPNS*HQ
WANPHRRRTSPGEDTNCHHLR*CQCCEK*NPNQR
RPYCPH*DQDHHL*GCPD*RQQWRLGPRSLADS
SNYHI*DPKQHHHNSNYQDCKRWDFRDTY*KEN
CDHRRC*Y*P*SGPCTSHQGGKGAAPRHVSDQGG
RPPGDRDC**VSSGTNLPQLCPSPIQEKPAK**
RS*PAIVRLQTFKIILNHQKINFSFYWEFIPRD
SSRSH*SF*RAFSILGYQNCSTFHSIDCFKSFGV
FLIGWFVTPSA*PLCPFISNPNRH*QGPWNSSG
NPPRTLVSCVGSQSQLSGTSASLPSLIPFG*WQ
KLHEPALSQSQ*CECIRMPGRAPALIHRPRKDAP
VPLLRVVLVRQSPLLRM*YCFSPLPPAFFLELL
WVKDMEVASDI*YCECLNISVAFTSPATLLPHQ
KQWLS*VLPLAPISGDQISQKNRHFGPKALMEHF
*W*FGEGKLMRFLK*GFLVLRVCTSHRGMGLLL
SDPGPFFHPK*QGMWLREGFFFFDLSSLNRNLP
EDTLLEQGIDF*EPFSPQDTT*QGV*APALLIPT
HQLRSVRF*RLDFVVGLGLSFPFFHFDF*K*R*
CPNSW*GFGA*FFVFLRRSFALVAQAGVQWRDL
GSLQPPPPGFKQFSCLSLPSSWDDRRTPPRPANF
LYF**KRDFTLLGWSRTPDLR*STHLGLPKCWD
YRCEPPRPADLGHFYLTELL*PSNCFPQTHWPQ
GSLESQFQLPKIDSGYRAAVTGAQGQ*AREMSKA
ASPNTVQSLHCLSFVSAGLNSFRVCAFFFWYPC
ET*TTGGRERAQVGRGTGLGERACPISGTKL*A
VGRGSERWALG*CPSLVVLPGVVTRNAAYIKRTC
SACPLPDGQMACRKSYQGFQTCGTKRMGKRQRA
LSVPLKTNPLNIPCDLEQCGSFHSTGPFIGGLN
VSLSSVTNSLLSASLSVNWMKRALMPFRLLEAID
LDKPSKMGVLPGLFPFPPSLATVLGVWQLFGFF
FFLQLCVCVFV*RKTDSVQVEMVRRGKRITFPG
SETWQQFS*SDSDTPQ*QLSLQFYFNLRNKDFLQ
AT*GLWHPPTKQDLYL*AEGSGSLTAGPVRAP*
PIPVPTPPSTAGPISVCWGDAWQLGVRRQQTSG
TGARAAA*LTPFDAHGKFLPRISAPGWLFLQISL
KCIILVTKMKELCKFFLKL*IISSSCLHFLKK*
ELGQQNQIGRIFRLHRQ*SSLLFWPFVVEVVVV
FRYLFGLASCIAFFSINNNKKNSLCED*STFKFL
FYQQLGKN*IWVGET*TQVIF*SKLPTLTKMQL
QR*VKGFLRAGQCLLPAAVRFCSIGHDKGRREG
ASQTYLQKGPELSMKALAVV*L*RDIPQMAEGRK
GLRW*EFKAQSPSQMAVESLIP

Frame 2

PGGAKWQEPLKGRERRGARTRSARSPPHPAQQH
HDNREEFSD*GRKFTAPTEGRG*GSHKLRPTRT
SAGGILSNSS*RR*LV*TEAESF*WRHSYT*RL
DQEQGADIRKQRTFTTILLVSQKAQISGVRGRRQ
RSRVR*RKR*RRSERDRIWNQS**RDHFKGPNC
SS*TGTQNRPIFGSSFIKQCRNTASPLQLRIIF
RVFLFLKHVNIICIVKSPAQEELREDPDFEIKEG
EGLEECSKIEVKEESPQSKAETELKASQKPIRK
HRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRV
CEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKK
QVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLC
LQLRQDIVAGRLPCSFATLALLGSYTIQSELGD
YDPELHGVDYVSDFKLAPNQTKELEEKVMELHKS
YRSMTPAQADLEFLENAKKLSMYGVDLHKAKDL
EGVDIILGVCSSGLLVYKDKLRINRFPWPKVLK
ISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAA
KKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSK
FRYSGRTQAQTRQASALIDRPAPHFERTASKRA
SRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGG
VLDASAKKTVVPKAQKETVKAEVKKEDEPPEQA
EPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRER
LDGENIYIRHSNLMLEDLDKSQEEIKKHHASISE
LKKNFMESVPEPRPSEWDKRLSTHSPFRTLNIN
GQIPTGEGPPLVKTQTVTISDNANAVKSEIPTK
DVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTA
QTITSETPSSTTTTQITKTVKGGISETRIEKRI
VITGDADIDHDQVLVQAIKEAKEQHPDMSVTKV
VVHQETEIADE*AQELTYPNSALLPSKRNQQNDK
EANLP*SDFRLSRLF*ITRKLISVSIGSLYQEI
LLDLIDPFEELFLY*DIRIVQLFTL*TVLRVLG
FF*LGGL*PLQPSLSAHLFPTPTDTDRVHGILRE
ILQGLLSAVLEAKASLVGLPRLSLVLSPLDDGR
NFMNQPFLRASDVSVSECQGGHQP*STDLGKMP
LFLCCGWFW*GRALC*ECSIVFPLSLLLSFWSFF
GSKTWKLLQISDTVNV*TYPWPSPLQLPFYLIR
SSGSAKCSP*LPSQETKSHRKIGTLGQKL*WNI
FSGDLGKES**GF*NKVF*F*ECALHTGEWGYFC
LILGLSFIPNDKECGSEKGFSFLTFLLSTGTCL
RTPF*SKELTFRSRSPHKTPHDKGYKPQPCSFP
LTS*GLSGFEGLILWWVWGLVFLFFILIFESEDD
ALIPGKDLGHSFLFF*DGVSLLLPKLECSGAIS
AHCNLRLLGSSSSLASASQVAGMTGAHHHAQQI
FCIFSRNGISPC*AGLELLTSGDPPTLASQSAGI
TGVSHHARPIWGIFI*QNFSNLPTASHKHIGLK
AP*NPSSSFLK*TVGIGQQSLGLKGSEQEKCLK
LLLPTPSKVSTA*VLFRLV*THFGCVHFSFGTHV
RHEQQEGGKEPRWDVGQA*GKELVLSQEQNYRL
WAEGLKGGLWGSAQAWSCCQEW*QEMQLTSNEH
VVHAHCLMARWPVGRATRASRPVERRGWGKGRGH
*VSL*KLTH*IFRVI*NSVAAFTAQDRSSGA*T
FPSALSPTHFSRLRCL*IG*KEL*CLSGS*KP*
IWTSPARWVSFQASSPFLHLWQQFLGFGNCLDFF
SFCSCVYVCLCEEKQTLSR*KW*GGGRELHFQG
QKLGNSFPRVTQTHHSNNSRCNFILI*EIKISS
KPHEDSGTHPQSKTCIYKPRAQGA*LRDPSGPRD
PSPSPPPPPPLGPSVCVGGMLGSWG*GDNKPRE
LEPELRPD*RLLMLTGNFCPGSQPQAGCFYKSL
SNVLFW*QK*RSFVNFF*NYESYQVVVYIS*KNR
NSGSRIRLAESLDYTGNNQVCCFGLS**KWL*C
LDICLVLLLVLHFFQ*TTTKRTLSVRIDPLLNF
SSTSNLGKIKYGWGRPKLKSFSKVSYPH*PKCSF
NVE*RDF*ELANAFCQLQ*DSAA*ATIKEGEKG
LLRLICRRAQNSV*RHWQ*CSSRGIYPRWLREE
RD*GGRSSRLSPRPRWQWRVSSR

Sequence NM_203343

GCCCCGGCGGGGCAAAGTGGCAGGAACCTCTTAAAGGGCGAGAGCGGCGCGGAGCCAGAACGCGGTCGGCCCGGTCCCCGCCGCACCCAGCCCAGCAACA
TCATGACAACAGAGAAGAGTTTAGTGACTGAGGCCGAAAATTCACAGCACCAACAGAAGGAAGAGGGTGAGGAAGCCATAAACTCAGGCCAACAAGAACC
TCAGCAGGAGGAATCTTGTCAAACAGCAGCTGAAGGAGATAATTGGTGTGAACAGAAGCTGAAAGCTTCTAATGGAGACACTCCTACACATGAAGACTTG
ACCAAGAACAAGGAGCGGACATCAGAAAGCAGAGGACTTTCACGACTATTCTCCTCGTTTCTCAAAAGGCCCAAATCTCAGGTGTCCGAGGAAGAAGGCA
AAGAAGTAGAGTCAGATAAAGAAAAAGGTGAAGGAGGTCAGAAAGAGATAGAATTTGGAACCAGTCTTGATGAAGAGATCATTTTAAAGGCCCCAATTGC
AGCTCCTGAACCGGAACTCAAAACAGACCCATCTTTGGATCTTCATTCATTAAGCAGTGCAGAAACACAGCCTGCTCAGGAAGAACTCAGAGAAGATCCA
GATTTTGAAATTAAGGAAGGAGAAGGACTTGAAGAGTGCTCCAAAATAGAAGTAAAAGAAGAAAGCCCTCAATCAAAAGCAGAAACAGAATTAAAAGCTT
CCCAAAAACCAATCAGAAAACACAGGAACATGCACTGCAAGGTTTCTTTGTTGGATGACACAGTTTATGAATGTGTTGTGGAGACATGGCTGGATTCCGC
CAAAGAAATAAAAAAGCAGGTTCGTGGTGTCCCTTGGAATTTTACATTTAATGTAAAGTTTTATCCACCTGACCCAGCACAGTTAACAGAAGACATAACA
AGATATTATTTATGTCTTCAGCTTCGGCAGGACATAGTTGCAGGACGTCTGCCCTGTTCCTTTGCAACCTTAGCATTATTAGGTTCTTACACCATCCAGT
CTGAACTGGGAGACTACGACCCAGAACTCCATGGCGTGGATTATGTTAGTGATTTTAAACTGGCCCCGAATCAGACCAAGGAACTTGAAGAGAAGGTCAT
GGAACTGCATAAGTCATACAGGTCCATGACTCCAGCTCAGGCTGACTTGGAGTTTCTTGAGAATGCCAAAAAGTTGTCTATGTATGGAGTTGATCTTCAT
AAAGCAAAGGACTTGGAAGGAGTAGATATCATCCTAGGTGTCTGCTCTAGTGGCCTTCTGGTTTACAAAGATAAGCTGAGAATTAACCGCTTCCCTTGGC
CCAAAGTGCTGAAGATTTCTTATAAACGTAGTAGCTTTTTCATCAAGATTCGGCCTGGAGAGCAAGAGCAGTATGAAAGTACCATCGGATTCAAACTTCC
CAGTTACCGAGCAGCTAAGAAATTATGGAAAGTCTGTGTAGAACATCACACGTTTTTCAGATTGACATCTACAGACACCATTCCCAAAAGCAAATTTCTT
GCGCTAGGATCCAAATTTCGATACAGTGGCCGGACTCAAGCTCAGACCAGGCAAGCTAGTGCTCTAATTGACAGGCCTGCCCCACACTTCGAGCGTACAG
CAAGTAAACGGGCGTCCCGGAGCCTCGATGGAGCAGCAGCTGTCGATTCGGCAGACCGAAGTCCTCGGCCCACTTCTGCACCTGCCATTACTCAGGGTCA
GGTTGCAGAAGGTGGCGTCCTAGATGCCTCTGCTAAAAAAACAGTGGTCCCTAAAGCACAGAAGGAAACAGTGAAGGCTGAAGTGAAAAAGGAAGACGAG
CCACCTGAGCAAGCTGAGCCAGAGCCCACAGAAGCATGGAAGGATTTAGACAAGAGTCAAGAGGAGATCAAAAAACATCATGCCAGCATCAGTGAGCTGA
AAAAGAACTTCATGGAGTCTGTACCAGAACCACGGCCTAGTGAATGGGATAAACGCTTATCCACTCACTCACCCTTCCGAACTCTTAACATCAATGGGCA
AATCCCCACAGGAGAAGGACCTCCCCTGGTGAAGACACAAACTGTCACCATCTCAGATAATGCCAATGCTGTGAAAAGTGAAATCCCAACCAAAGACGTC
CCTATTGTCCACACTGAGACCAAGACCATCACTTATGAGGCTGCCCAGACTGACGACAACAGTGGAGACTTGGACCCAGGAGTCTTGCTGACAGCTCAAA
CTATCACATCTGAGACCCCAAGCAGCACCACCACAACTCAAATTACCAAGACTGTAAAAGGTGGGATTTCAGAGACACGTATTGAAAAGAGAATTGTGAT
CACAGGAGATGCTGATATTGACCATGATCAGGTCCTTGTACAAGCCATCAAGGAGGCAAAGGAGCAGCACCCAGACATGTCAGTGACCAAGGTGGTCGTC
CACCAGGAGACCGAGATTGCTGATGAGTGAGCTCAGGAACTAACCTACCCCAACTCTGCCCTTCTCCCATCCAAGAGAAACCAGCAAAATGATAAAGAAG
CTAACCTGCCATAGTCAGACTTCAGACTTTCAAGATTATTCTAAATCACCAGAAAATTAATTTCAGTTTCTATTGGGAGTTTATACCAAGAGATTCTTCT
AGATCTCATTGATCCTTTTGAAGAGCTTTTTCTATATTAGGATATCAGAATTGTTCAACTTTTCACTCTATAGACTGTTTTAAGAGTTTTGGGGTTTTTT
TAATTGGGTGGTTTGTAACCCCTTCAGCCTAGCCTCTCTGCCCATTTATTTCCAACCCCAACAGACACTGACAGGGTCCATGGAATTCTTCGGGAAATCC
TCCAAGGACTCTTGTCAGCTGTGTTGGAAGCCAAAGCCAGCTTAGTGGGACTTCCGCGTCTCTCCCTAGTCTTATCCCCTTTGGATGATGGCAGAAACTT
CATGAACCAGCCCTTTCTCAGAGCCAGTGATGTGAGTGTATCAGAATGCCAGGGAGGGCACCAGCCCTGATCCACAGACCTCGGAAAGATGCCCCTGTTC
CTTTGTTGCGGGTGGTTTTGGTAAGGCAGAGCCCTCTGCTGAGAATGTAGTATTGTTTTTCCCCTCTCCCTCCTGCTTTCTTTTTGGAGCTTCTTTGGGT
CAAAGACATGGAAGTTGCTTCAGATATCTGATACTGTGAATGTTTGAACATATCCGTGGCCTTCACCTCTCCAGCTACCCTTTTACCTCATCAGAAGCAG
TGGCTCAGCTAAGTGCTCCCCCTAGCTCCCATCTCAGGAGACCAAATCTCACAGAAAAATAGGCACTTTGGGCCAAAAGCTCTAATGGAACATTTTTAGT
GGTGATTTGGGGAAGGAAAGTTAATGAGGTTTTTAAAATAAGGTTTTCTAGTTTTGAGAGTGTGCACTTCACACAGGGGAATGGGGTTACTTCTGTCTGA
TCCTGGGCCTTTCTTTCATCCCAAATGACAAGGAATGTGGCTCAGAGAAGGGTTTTTCTTTTTTGACCTTTCTTCTCTCAACAGGAACCTGCCTGAGGAC
ACCCTTCTAGAGCAAGGAATTGACTTTTAGGAGCCGTTCTCCCCACAAGACACCACATGACAAGGGGTATAAGCCCCAGCCCTGCTCATTCCCACTCACC
AGCTGAGGTCTGTCAGGTTTTGAAGGCTTGATTTTGTGGTGGGTTTGGGGCTTAGTTTTCCTTTTTTTCATTTTGATTTTTGAAAGTGAAGATGATGCCC
TAATTCCTGGTAAGGATTTGGGGCATAGTTTTTTGTTTTTTTGAGACGGAGTTTCGCTCTTGTTGCCCAAGCTGGAGTGCAGTGGCGCGATCTCGGCTCA
CTGCAACCTCCGCCTCCTGGGTTCAAGCAGTTCTCTTGCCTCAGCCTCCCAAGTAGCTGGGATGACAGGCGCACACCACCACGCCCAGCAAATTTTTTGT
ATTTTTAGTAGAAACGGGATTTCACCTTGTTAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAG
GTGTGAGCCACCACGCCCGGCCGATTTGGGGCATTTTTATTTAACAGAACTTCTCTAACCTTCCAACTGCTTCCCACAAACACATTGGCCTCAAGGCTCC
TTAGAATCCCAGTTCCAGCTTCCTAAAATAGACAGTGGGTATCGGGCAGCAGTCACTGGGGCTCAAGGGCAGTGAGCAAGAGAAATGTCTAAAGCTGCTT
CTCCCAACACCGTCCAAAGTCTCCACTGCCTGAGTTTTGTTTCGGCTGGTTTGAACTCATTTCGGGTGTGTGCATTTTTCTTTTGGTACCCATGTGAGAC
ATGAACAACAGGAGGGAGGGAAAGAGCCCAGGTGGGACGTGGGACAGGCTTAGGGGAAAGAGCTTGTCCTATCTCAGGAACAAAATTATAGGCTGTGGGC
AGAGGGTCTGAAAGGTGGGCTTTGGGGTAGTGCCCAAGCCTGGTCGTGTTGCCAGGAGTGGTGACAAGAAATGCAGCTTACATCAAACGAACATGTAGTG
CATGCCCACTGCCTGATGGCCAGATGGCCTGTAGGAAGAGCTACCAGGGCTTCCAGACCTGTGGAACGAAGAGGATGGGGAAAAGGCAGAGGGCACTGAG
TGTCCCTTTAAAAACTAACCCACTGAATATTCCGTGTGATCTAGAACAGTGTGGCAGCTTTCACAGCACAGGACCGTTCATCGGGGGCCTAAACGTTTCC
CTCAGCTCTGTCACCAACTCACTTCTCTCGGCTTCGTTGTCTGTAAATTGGATGAAAAGAGCTCTAATGCCTTTCAGGCTCTTAGAAGCCATAGATTTGG
ACAAGCCCAGCAAGATGGGTGTCCTTCCAGGCCTCTTCCCCTTTCCTCCATCTCTGGCAACAGTTCTTGGGGTTTGGCAATTGTTTGGATTTTTTTTCTT
TCTGCAGTTGTGTGTATGTGTGTTTGTGTGAAGAAAAACAGACTCTGTCCAGGTAGAAATGGTGAGGAGGGGGAAGAGAATTACATTTCCAGGGTCAGAA
ACTTGGCAACAGTTTTCCTAGAGTGACTCAGACACACCACAGTAACAACTCTCGCTGCAATTTTATTTTAATTTGAGAAATAAAGATTTCCTCCAAGCCA
CATGAGGACTCTGGCACCCACCCACAAAGCAAGACCTGTATTTATAAGCCGAGGGCTCAGGGAGCCTAACTGCGGGACCCGTCAGGGCCCCGTGACCCAT
CCCCGTCCCCACCCCCCCCTCCACCGCTGGGCCCATCAGTGTGTGTTGGGGGGATGCTTGGCAGCTGGGGGTGAGGAGACAACAAACCTCGGGAACTGGA
GCCAGAGCTGCGGCCTGACTGACGCCTTTTGATGCTCACGGGAAATTTCTGCCCAGGATCTCAGCCCCAGGCTGGTTGTTTCTACAAATCTCTCTCAAAT
GTATTATTTTGGTGACAAAAATGAAGGAGCTTTGTAAATTTTTTTTAAAATTATGAATCATATCAAGTAGTTGTTTACATTTCTTGAAAAAATAGGAACT
CGGGCAGCAGAATCAGATTGGCAGAATCTTTAGACTACACAGGCAATAATCAAGTCTGCTGTTTTGGCCTTTCGTAGTAGAAGTGGTTGTAGTGTTTAGA
TATCTGTTTGGTCTTGCTTCTTGTATTGCATTTTTTTCAATAAACAACAACAAAAAGAACTCTCTCTGTGAGGATTGATCCACTTTTAAATTTCTCTTCT
ACCAGCAACTTGGGAAAAATTAAATATGGGTGGGGGAGACCTAAACTCAAGTCATTTTCTAAAGTAAGTTACCCACATTGACCAAAATGCAGCTTCAACG
TTGAGTAAAGGGATTTCTGAGAGCTGGCCAATGCCTTTTGCCAGCTGCAGTGAGATTCTGCAGCATAGGCCACGATAAAGGAAGGAGAGAAGGGGCTTCT
CAGACTTATTTGCAGAAGGGCCCAGAACTCAGTATGAAGGCATTGGCAGTAGTGTAGCTCTAGAGGGATATACCCCAGATGGCTGAGGGAAGAAAGGGAT
TGAGGTGGTAGGAGTTCAAGGCTCAGTCCCCGTCCCAGATGGCAGTGGAGAGTCTCATCCCGTG
  • refseq_EPB41.F1 (forward primer)
  • refseq_EPB41.R1 (reverse primer)
  • Single exon skipping

Frame 0

APAGQSGRNLLKGESGAEPERGRPGPRRTQPSN
IMTTEKSLVTEAENSQHQQKEEGEEAINSGQQEP
QQEESCQTAAEGDNWCEQKLKASNGDTPTHEDL
TKNKERTSESRGLSRLFSSFLKRPKSQVSEEEG
KEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIA
APEPELKTDPSLDLHSLSSAETQPAQEELREDP
DFEIKEGEGLEECSKIEVKEESPQSKAETELKA
SQKPIRKHRNMHCKVSLLDDTVYECVVETWLDSA
KEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDIT
RYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQ
SELGDYDPELHGVDYVSDFKLAPNQTKELEEKVM
ELHKSYRSMTPAQADLEFLENAKKLSMYGVDLH
KAKDLEGVDIILGVCSSGLLVYKDKLRINRFPW
PKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLP
SYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFL
ALGSKFRYSGRTQAQTRQASALIDRPAPHFERT
ASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQ
VAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKDLDKSQEEIKKHHASISEL
KKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQ
IPTGEGPPLVKTQTVTISDNANAVKSEIPTKDV
PIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQ
TITSETPSSTTTTQITKTVKGGISETRIEKRIVI
TGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVV
HQETEIADE*AQELTYPNSALLPSKRNQQNDKE
ANLP*SDFRLSRLF*ITRKLISVSIGSLYQEILL
DLIDPFEELFLY*DIRIVQLFTL*TVLRVLGFF
*LGGL*PLQPSLSAHLFPTPTDTDRVHGILREI
LQGLLSAVLEAKASLVGLPRLSLVLSPLDDGRNF
MNQPFLRASDVSVSECQGGHQP*STDLGKMPLF
LCCGWFW*GRALC*ECSIVFPLSLLLSFWSFFG
SKTWKLLQISDTVNV*TYPWPSPLQLPFYLIRSS
GSAKCSP*LPSQETKSHRKIGTLGQKL*WNIFS
GDLGKES**GF*NKVF*F*ECALHTGEWGYFCL
ILGLSFIPNDKECGSEKGFSFLTFLLSTGTCLRT
PF*SKELTFRSRSPHKTPHDKGYKPQPCSFPLT
S*GLSGFEGLILWWVWGLVFLFFILIFESEDDA
LIPGKDLGHSFLFF*DGVSLLLPKLECSGAISAH
CNLRLLGSSSSLASASQVAGMTGAHHHAQQIFC
IFSRNGISPC*AGLELLTSGDPPTLASQSAGIT
GVSHHARPIWGIFI*QNFSNLPTASHKHIGLKAP
*NPSSSFLK*TVGIGQQSLGLKGSEQEKCLKLL
LPTPSKVSTA*VLFRLV*THFGCVHFSFGTHVR
HEQQEGGKEPRWDVGQA*GKELVLSQEQNYRLWA
EGLKGGLWGSAQAWSCCQEW*QEMQLTSNEHVV
HAHCLMARWPVGRATRASRPVERRGWGKGRGH*
VSL*KLTH*IFRVI*NSVAAFTAQDRSSGA*TFP
SALSPTHFSRLRCL*IG*KEL*CLSGS*KP*IW
TSPARWVSFQASSPFLHLWQQFLGFGNCLDFFS
FCSCVYVCLCEEKQTLSR*KW*GGGRELHFQGQK
LGNSFPRVTQTHHSNNSRCNFILI*EIKISSKP
HEDSGTHPQSKTCIYKPRAQGA*LRDPSGPRDP
SPSPPPPPPLGPSVCVGGMLGSWG*GDNKPRELE
PELRPD*RLLMLTGNFCPGSQPQAGCFYKSLSN
VLFW*QK*RSFVNFF*NYESYQVVVYIS*KNRN
SGSRIRLAESLDYTGNNQVCCFGLS**KWL*CLD
ICLVLLLVLHFFQ*TTTKRTLSVRIDPLLNFSS
TSNLGKIKYGWGRPKLKSFSKVSYPH*PKCSFN
VE*RDF*ELANAFCQLQ*DSAA*ATIKEGEKGLL
RLICRRAQNSV*RHWQ*CSSRGIYPRWLREERD
*GGRSSRLSPRPRWQWRVSSR

Frame 1

PRRGKVAGTS*RARAARSQNAVGPVPAAPSPAT
S*QQRRV**LRPKIHSTNRRKRVRKP*TQANKN
LSRRNLVKQQLKEIIGVNRS*KLLMETLLHMKT*
PRTRSGHQKAEDFHDYSPRFSKGPNLRCPRKKA
KK*SQIKKKVKEVRKR*NLEPVLMKRSF*RPQL
QLLNRNSKQTHLWIFIH*AVQKHSLLRKNSEKIQ
ILKLRKEKDLKSAPK*K*KKKALNQKQKQN*KL
PKNQSENTGTCTARFLCWMTQFMNVLWRHGWIP
PKK*KSRFVVSLGILHLM*SFIHLTQHS*QKT*Q
DIIYVFSFGRT*LQDVCPVPLQP*HY*VLTPSS
LNWETTTQNSMAWIMLVILNWPRIRPRNLKRRS
WNCISHTGP*LQLRLTWSFLRMPKSCLCMELIFI
KQRTWKE*ISS*VSALVAFWFTKIS*ELTASLG
PKC*RFLINVVAFSSRFGLESKSSMKVPSDSNF
PVTEQLRNYGKSV*NITRFSD*HLQTPFPKANFL
R*DPNFDTVAGLKLRPGKLVL*LTGLPHTSSVQ
QVNGRPGASMEQQLSIRQTEVLGPLLHLPLLRV
RLQKVAS*MPLLKKQWSLKHRRKQ*RLK*KRKTS
HLSKLSQSPQKHGRI*TRVKRRSKNIMPASVS*
KRTSWSLYQNHGLVNGINAYPLTHPSELLTSMG
KSPQEKDLPW*RHKLSPSQIMPML*KVKSQPKTS
LLSTLRPRPSLMRLPRLTTTVETWTQESC*QLK
LSHLRPQAAPPQLKLPRL*KVGFQRHVLKREL*
SQEMLILTMIRSLYKPSRRQRSSTQTCQ*PRWSS
TRRPRLLMSELRN*PTPTLPFSHPRETSKMIKK
LTCHSQTSDFQDYSKSPEN*FQFLLGVYTKRFF
*ISLILLKSFFYIRISELFNFSLYRLF*EFWGFF
NWVVCNPFSLASLPIYFQPQQTLTGSMEFFGKS
SKDSCQLCWKPKPA*WDFRVSP*SYPLWMMAET
S*TSPFSEPVM*VYQNAREGTSPDPQTSERCPCS
FVAGGFGKAEPSAENVVLFFPSPSCFLFGASLG
QRHGSCFRYLIL*MFEHIRGLHLSSYPFTSSEA
VAQLSAPPSSHLRRPNLTEK*ALWAKSSNGTFLV
VIWGRKVNEVFKIRFSSFESVHFTQGNGVTSV*
SWAFLSSQMTRNVAQRRVFLF*PFFSQQEPA*G
HPSRARN*LLGAVLPTRHHMTRGISPSPAHSHSP
AEVCQVLKA*FCGGFGA*FSFFSF*FLKVKMMP
*FLVRIWGIVFCFFETEFRSCCPSWSAVARSRL
TATSASWVQAVLLPQPPK*LG*QAHTTTPSKFFV
FLVETGFHLVRLVSNS*PQVIHPPWPPKVLGLQ
V*ATTPGRFGAFLFNRTSLTFQLLPTNTLASRL
LRIPVPAS*NRQWVSGSSHWGSRAVSKRNV*SCF
SQHRPKSPLPEFCFGWFELISGVCIFLLVPM*D
MNNRREGKSPGGTWDRLRGKSLSYLRNKIIGCG
QRV*KVGFGVVPKPGRVARSGDKKCSLHQTNM*C
MPTA*WPDGL*EELPGLPDLWNEEDGEKAEGTE
CPFKN*PTEYSV*SRTVWQLSQHRTVHRGPKRF
PQLCHQLTSLGFVVCKLDEKSSNAFQALRSHRFG
QAQQDGCPSRPLPLSSISGNSSWGLAIVWIFFL
SAVVCMCVCVKKNRLCPGRNGEEGEENYISRVR
NLATVFLE*LRHTTVTTLAAILF*FEK*RFPPSH
MRTLAPTHKARPVFISRGLREPNCGTRQGPVTH
PRPHPPLHRWAHQCVLGGCLAAGGEETTNLGNW
SQSCGLTDAF*CSREISAQDLSPRLVVSTNLSQM
YYFGDKNEGAL*IFFKIMNHIK*LFTFLEKIGT
RAAESDWQNL*TTQAIIKSAVLAFRSRSGCSV*
ISVWSCFLYCIFFNKQQQKELSL*GLIHF*ISLL
PATWEKLNMGGGDLNSSHFLK*VTHIDQNAAST
LSKGISESWPMPFASCSEILQHRPR*RKERRGF
SDLFAEGPRTQYEGIGSSVALEGYTPDG*GKKGI
EVVGVQGSVPVPDGSGESHPV

Frame 2

PGGAKWQEPLKGRERRGARTRSARSPPHPAQQH
HDNREEFSD*GRKFTAPTEGRG*GSHKLRPTRT
SAGGILSNSS*RR*LV*TEAESF*WRHSYT*RL
DQEQGADIRKQRTFTTILLVSQKAQISGVRGRRQ
RSRVR*RKR*RRSERDRIWNQS**RDHFKGPNC
SS*TGTQNRPIFGSSFIKQCRNTACSGRTQRRS
RF*N*GRRRT*RVLQNRSKRRKPSIKSRNRIKSF
PKTNQKTQEHALQGFFVG*HSL*MCCGDMAGFR
QRNKKAGSWCPLEFYI*CKVLST*PSTVNRRHN
KILFMSSASAGHSCRTSALFLCNLSIIRFLHHPV
*TGRLRPRTPWRGLC**F*TGPESDQGT*REGH
GTA*VIQVHDSSSG*LGVS*ECQKVVYVWS*SS
*SKGLGRSRYHPRCLL*WPSGLQR*AEN*PLPLA
QSAEDFL*T**LFHQDSAWRARAV*KYHRIQTS
QLPSS*EIMESLCRTSHVFQIDIYRHHSQKQIS
CARIQISIQWPDSSSDQAS*CSN*QACPTLRAYS
K*TGVPEPRWSSSCRFGRPKSSAHFCTCHYSGS
GCRRWRPRCLC*KNSGP*STEGNSEG*SEKGRR
AT*AS*ARAHRSMEGFRQESRGDQKTSCQHQ*AE
KELHGVCTRTTA**MG*TLIHSLTLPNS*HQWA
NPHRRRTSPGEDTNCHHLR*CQCCEK*NPNQRR
PYCPH*DQDHHL*GCPD*RQQWRLGPRSLADSSN
YHI*DPKQHHHNSNYQDCKRWDFRDTY*KENCD
HRRC*Y*P*SGPCTSHQGGKGAAPRHVSDQGGR
PPGDRDC**VSSGTNLPQLCPSPIQEKPAK**RS
*PAIVRLQTFKIILNHQKINFSFYWEFIPRDSS
RSH*SF*RAFSILGYQNCSTFHSIDCFKSFGVF
LIGWFVTPSA*PLCPFISNPNRH*QGPWNSSGNP
PRTLVSCVGSQSQLSGTSASLPSLIPFG*WQKL
HEPALSQSQ*CECIRMPGRAPALIHRPRKDAPV
PLLRVVLVRQSPLLRM*YCFSPLPPAFFLELLWV
KDMEVASDI*YCECLNISVAFTSPATLLPHQKQ
WLS*VLPLAPISGDQISQKNRHFGPKALMEHF*
W*FGEGKLMRFLK*GFLVLRVCTSHRGMGLLLSD
PGPFFHPK*QGMWLREGFFFFDLSSLNRNLPED
TLLEQGIDF*EPFSPQDTT*QGV*APALLIPTH
QLRSVRF*RLDFVVGLGLSFPFFHFDF*K*R*CP
NSW*GFGA*FFVFLRRSFALVAQAGVQWRDLGS
LQPPPPGFKQFSCLSLPSSWDDRRTPPRPANFL
YF**KRDFTLLGWSRTPDLR*STHLGLPKCWDYR
CEPPRPADLGHFYLTELL*PSNCFPQTHWPQGS
LESQFQLPKIDSGYRAAVTGAQGQ*AREMSKAA
SPNTVQSLHCLSFVSAGLNSFRVCAFFFWYPCET
*TTGGRERAQVGRGTGLGERACPISGTKL*AVG
RGSERWALG*CPSLVVLPGVVTRNAAYIKRTCS
ACPLPDGQMACRKSYQGFQTCGTKRMGKRQRALS
VPLKTNPLNIPCDLEQCGSFHSTGPFIGGLNVS
LSSVTNSLLSASLSVNWMKRALMPFRLLEAIDL
DKPSKMGVLPGLFPFPPSLATVLGVWQLFGFFFF
LQLCVCVFV*RKTDSVQVEMVRRGKRITFPGSE
TWQQFS*SDSDTPQ*QLSLQFYFNLRNKDFLQA
T*GLWHPPTKQDLYL*AEGSGSLTAGPVRAP*PI
PVPTPPSTAGPISVCWGDAWQLGVRRQQTSGTG
ARAAA*LTPFDAHGKFLPRISAPGWLFLQISLK
CIILVTKMKELCKFFLKL*IISSSCLHFLKK*EL
GQQNQIGRIFRLHRQ*SSLLFWPFVVEVVVVFR
YLFGLASCIAFFSINNNKKNSLCED*STFKFLF
YQQLGKN*IWVGET*TQVIF*SKLPTLTKMQLQR
*VKGFLRAGQCLLPAAVRFCSIGHDKGRREGAS
QTYLQKGPELSMKALAVV*L*RDIPQMAEGRKG
LRW*EFKAQSPSQMAVESLIP

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