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Sequences

Sequence NM_018682

CGCCGCCATTTTCCCAGAGCGAGAGGCAGTGACACTGAGCGGGCGCAGGGGGCCGAGTCGGAGACCGTGCCGGAGTTCGGGAGCGGCAACAGAGTGGGCA TAGACACTCCGAGCAGCCTCGCCGTCGTCTCTGCGTTCCTGTTGACTGCCTGGCTGCCCCCTCCCCTACTCCTCGGTTCCTGGTGAAGAGGCTGCGCGCT GCTGTTTGGGGAGGGGGTGTGTGGAGCCGGGTCCTGTGTCCGCAGTGGCTGCTGTCGGGGGGTCGCCTGTTCGCGGAGGTGCGGAGAGACTCCTTGGGGG TCGAGCACTGTGGCTGGCATGCCCCAGTGTTTTGGATACCAATGCATAGGACTCCATAGTAATCGAATTTACCAGAGGCGAACGTCATGAGCATAGTGAT CCCATTGGGGGTTGATACAGCAGAGACGTCATACTTGGAAATGGCTGCAGGTTCAGAACCAGAATCCGTAGAAGCTAGCCCTGTGGTAGTTGAGAAATCC AACAGTTATCCCCACCAGTTATATACCAGCAGCTCACATCATTCACACAGTTACATTGGTTTGCCCTATGCGGACCATAATTATGGTGCTCGTCCTCCTC CGACACCTCCGGCTTCCCCTCCTCCATCAGTCCTTATTAGCAAAAATGAAGTAGGCATATTTACCACTCCTAATTTTGATGAAACTTCCAGTGCTACTAC AATCAGCACATCTGAGGATGGAAGTTATGGTACTGATGTAACCAGGTGCATATGTGGTTTTACACATGATGATGGATACATGATCTGTTGTGACAAATGC AGCGTTTGGCAACATATTGACTGCATGGGGATTGATAGGCAGCATATTCCTGATACATATCTATGTGAACGTTGTCAGCCTAGGAATTTGGATAAAGAGA GGGCAGTGCTACTACAACGCCGGAAAAGGGAAAATATGTCAGATGGTGATACCAGTGCAACTGAGAGTGGTGATGAGGTTCCTGTGGAATTATATACTGC ATTTCAGCATACTCCAACATCAATTACTTTAACTGCTTCAAGAGTTTCCAAAGTTAATGATAAAAGAAGGAAAAAAAGCGGGGAGAAAGAACAACACATT TCAAAATGTAAAAAGGCATTTCGTGAAGGATCTAGGAAGTCATCAAGAGTTAAGGGTTCAGCTCCAGAGATTGATCCTTCATCTGATGGTTCAAATTTTG GATGGGAGACAAAGATCAAAGCATGGATGGATCGATATGAAGAAGCAAATAACAACCAGTACAGTGAGGGTGTTCAGAGGGAGGCACAAAGAATAGCTCT GAGATTAGGCAATGGAAATGACAAAAAAGAGATGAATAAATCCGATTTGAATACCAACAATTTGCTCTTCAAACCTCCTGTAGAGAGCCATATACAAAAG AATAAGAAAATTCTTAAATCTGCAAAAGATTTGCCTCCTGATGCACTTATCATTGAATACAGAGGGAAGTTTATGCTGAGAGAACAGTTTGAAGCAAATG GGTATTTCTTTAAAAGACCATACCCTTTTGTGTTATTCTACTCTAAATTTCATGGGCTAGAAATGTGTGTTGATGCAAGGACTTTTGGGAATGAGGCTCG ATTCATCAGGCGGTCTTGTACACCCAATGCAGAGGTGAGGCATGAAATTCAAGATGGAACCATACATCTTTATATTTATTCTATACACAGTATTCCAAAG GGAACTGAAATTACTATTGCCTTTGATTTTGACTATGGAAATTGTAAGTACAAGGTGGACTGTGCATGCCTCAAAGAAAACCCAGAGTGCCCTGTTCTAA AACGTAGTTCTGAATCCATGGAAAATATCAATAGTGGTTATGAGACCAGACGGAAAAAAGGAAAAAAAGACAAAGATATTTCAAAAGAAAAAGATACACA AAATCAGAATATTACTTTGGATTGTGAAGGAACGACCAACAAAATGAAGAGCCCAGAAACTAAACAAAGAAAGCTTTCTCCACTGAGACTATCAGTATCA AATAATCAGGAACCAGATTTTATTGATGATATAGAAGAAAAAACTCCTATTAGTAATGAAGTAGAAATGGAATCAGAGGAGCAGATTGCAGAAAGGAAAA GGAAGATGACAAGAGAAGAAAGAAAAATGGAAGCAATTTTGCAAGCTTTTGCCAGACTTGAAAAGAGAGAGAAAAGAAGAGAACAAGCTTTGGAAAGGAT CAGCACAGCCAAAACTGAAGTTAAAACTGAATGTAAAGATACACAGATTGTCAGTGATGCTGAAGTTATTCAGGAACAAGCAAAAGAAGAAAATGCTAGC AAGCCAACCCCTGCCAAAGTAAATAGAACTAAACAGAGAAAAAGTTTTTCTCGGAGTAGGACTCACATTGGACAGCAGCGTCGGAGACACAGAACTGTCA GCATGTGTTCAGATATCCAGCCATCTTCTCCTGATATAGAAGTTACTTCACAACAAAATGATATTGAAAATACTGTACTTACAATAGAACCAGAAACTGA AACTGCACTAGCAGAAATAATTACTGAAACTGAAGTTCCAGCACTTAATAAATGTCCTACCAAGTACCCCAAAACAAAGAAGCACTTGGTTAATGAATGG TTAAGTGAGAAGAATGAGAAGACAGGAAAACCTTCAGATGGCCTTTCAGAAAGGCCTCTACGCATAACTACAGATCCTGAAGTGTTAGCTACACAACTCA ATTCTTTACCAGGTCTCACTTACAGCCCCCATGTATACTCCACTCCTAAGCATTATATTAGATTTACTTCACCATTCCTTTCAGAAAAAAGGAGAAGAAA AGAACCTACTGAAAACATTTCTGGTTCATGCAAGAAGCGATGGTTGAAACAAGCTCTGGAAGAAGAAAATTCAGCAATTTTACATAGATTTAATTCACCC TGTCAAGAAAGATCCAGAAGTCCTGCAGTCAATGGTGAAAATAAAAGTCCACTACTATTAAATGACAGCTGTTCCCTTCCAGATTTAACTACACCACTAA AAAAACGAAGATTTTATCAGTTGCTAGATTCGGTTTACTCAGAAACCTCCACACCTACTCCTTCCCCGTATGCTACACCAACTCACACCGATATTACTCC TATGGACCCATCTTTTGCCACGCCTCCACGGATAAAATCAGATGATGAAACTTGTAGAAATGGTTATAAACCCATATATTCACCAGTTACCCCAGTAACT CCTGGTACACCAGGAAATACCATGCACTTTGAGAATATTTCTTCCCCAGAAAGTTCTCCAGAAATAAAGAGACGCACTTATAGTCAAGAGGGATATGACA GATCTTCAACCATGTTAACATTGGGGCCTTTTAGAAATTCTAATTTAACTGAACTGGGTCTGCAAGAAATAAAGACTATTGGTTATACGAGCCCTAGGAG TAGGACTGAAGTCAACAGGCAGTGTCCTGGAGAAAAGGAACCTGTGTCAGACCTTCAGCTAGGACTCGATGCAGTTGAGCCAACTGCCCTACATAAAACC CTGGAAACGCCTGCACATGACAGGGCTGAGCCCAACAGCCAACTGGACTCGACTCACTCTGGACGGGGCACAATGTATTCTTCCTGGGTAAAGAGCCCTG ACAGAACAGGAGTTAACTTCTCAGTGAACTCCAACTTGAGGGACCTGACACCCTCGCATCAGTTGGAGGTTGGAGGAGGCTTCCGAATAAGTGAGTCAAA GTGCCTGATGCAGGATGATACTAGAGGCATGTTTATGGAAACAACTGTGTTTTGTACTTCCGAAGATGGGCTTGTATCTGGTTTCGGACGGACTGTTAAT GACAATTTGATCGACGGGAATTGCACACCCCAGAATCCACCACAAAAGAAAAAGGTTTCTCTATTAGAATACCGTAAGAGACAACGTGAAGCTAGGAAAA GTGGCTCTAAGACAGAGAACTTTCCACTCATTAGTGTATCACCCCATGCAAGTGGAAGCTTGAGCAACAATGGTGATGGCTGTGCCAGCAGTAATGACAA TGGGGAGCAGGTGGACCACACTGCTAGCCTACCTTTACCAACACCAGCTACAGTTTATAATGCCACTTCTGAAGAAACTAGCAATAACTGCCCTGTTAAG GATGCTACTGCTAGTGAGAAGAATGAACCAGAAGTTCAATGGACTGCCTCAACTTCAGTGGAACAAGTCAGAGAAAGGAGTTATCAGAGAGCTTTACTTC TCAGTGATCACCGAAAAGATAAAGATAGTGGGGGAGAATCACCATGTGTCTCATGTTCACCGAGTCATGTTCAGTCTTCACCTTCATCTCATTCAAATCA CATACCCCAGTTGCAAGCTAAGGGCCCAGTCCCTTCTTTCAGTGAACTTATGGAAGACCCTGATCCTGAAAATCCAGAACCCACAACTACGAATGAATGT CCATCCCCAGATACTTCTCAAAATACTTGTAAAAGTCCTCCAAAAATGAGCAAGCCTGGTTCACCTGGATCTGTAATTCCTGCTCAAGCACACGGGAAAA TATTCACAAAACCAGATCCCCAATGGGACTCCACAGTTAGTGCATCCGAAGCTGAAAATGGTGTTCACCTAAAAACAGAGCTCCAACAAAAACAGCTATC AAATAACAACCAAGCACTTTCAAAGAATCATCCTCCTCAGACACACGTTCGTAATTCATCTGAGCAACTTTCACAAAAGCTGCCTTCTGTGCCAACAAAG TTGCACTGTCCTCCATCACCTCACCTAGAAAATCCTCCAAAGTCATCCACGCCTCACACACCTGTACAGCATGGTTATCTTTCACCAAAGCCTCCTTCAC AGCAGTTAGGATCTCCCTACAGGCCTCATCATTCACAGTCACCTCAAGTTGGAACACCTCAGCGAGAGCCTCAAAGAAACTTTTATCCAGCAGCACAGAA CCTTCCAGCCAATACTCAGCAGGCAACTTCTGGAACATTATTTACACAGACACCCTCAGGACAATCTTCAGCAACATACAGTCAGTTTAACCAACAAAGT CTGAACAGCACGGCACCACCCCCTCCACCTCCTCCACCTCCTTCTTCGTCTTACTATCAAAACCAGCAGCCCTCTGCAAACTTTCAGAATTATAATCAGC TCAAAGGTAGTCTTTCTCAACAAACTGTGTTTACATCAGGACCAAATCAAGCACTTCCTGGCACCACAAGCCAGCAAACAGTTCCAGGACACCACGTGAC TCCAGGGCATTTTTTGCCCTCTCAGAACCCTACCATTCACCATCAAACTGCTGCTGCCGTAGTCCCCCCTCCTCCTCCACCACCACCTGCTCCAGGACCG CACCTTGTACAACAGCCGAATTCCCATCAGCAACACTCTGTAGCACATGTAGTAGGGCCTGTTCATGCGGTCACCCCTGGGTCGCATATTCATTCTCAAA CTGCTGGACACCACTTACCCCCACCCCCACCCCCTCCTGGTCCTGCCCCTCATCACCATCCACCACCCCATCCATCCACAGGACTCCAAGGTCTACAAGC ACAACACCAGCATGTTGTAAATTCAGCACCCCCACCACCCCCTCCGCCGCCACCTTCCAGTGTTTTGGCTTCTGGGCATCATACCACATCAGCTCAAGCC TTACACCACCCACCTCATCAAGGACCTCCACTTTTTCCTTCGAGTGCTCATCCAACTGTACCACCGTATCCCTCACAAGCTACACATCATACCACTTTGG GACCGGGACCCCAGCACCAGCCTTCTGGAACAGGGCCACATTGTCCATTACCTGTCACAGGTCCTCATCTCCAGCCCCAAGGACCAAACAGTATTCCAAC ACCTACTGCTTCAGGGTTCTGTCCTCATCCTGGCTCTGTGGCCCTGCCACATGGGGTTCAAGGACCTCAGCAGGCATCTCCAGTGCCTGGACAGATTCCA ATTCACAGAGCACAGGTGCCACCAACATTTCAAAACAATTACCATGGGTCAGGGTGGCATTAAAATGGACTCCAAAAACATTTTTTTAAATGTTCTGTAA GATAAACTGTATATTTCATATGTACCTGTTAAGGTACTTTTTAAAGCTTGTACATGAACCTTTGTATAAAAAACACCAGTGCTCTTTCGTTGTATTTTTC TCATTTTTGCTTTTTAAAATTCCTTTAAAAAATGTGCTGTTAAGCCAGTATTAGGTATCTTTATTTTGTAAGTGAACATTCCAGCTGTTTTTTTCTGGCA GATCTGATGCTGATTTGATGCTGTATGATCTTTTTTTTTTTTTTAGTTAAATTCATTTAGTGAATGTTCTATTATTTTATACATACACATTAAGTACTCA GCTAAGTAATGGCACTATGAGGATTTTTTTTTTCTTTCCTGTCAGCAGCAGTTCTGTGAATGCATCTTAGGTATAAAAATGCAATACAGATTTTTATATT TTGGTGTGGACATGGCTCATTTTGTTTTACCAGTTATTTGCAAGCAAAATGTAATTTAATGTATAGATGATTTCTAATGTCTCCTGACAAACTGTAAATA CTGCATTTCTTTTGCGTATATAATTGCTTACAGCTTTTCTCATTTGATATATAGCATTGTACATATGACAAGTCTTTTGCAAAACTGTGTGATCTTTGTG AAAGTAGTACAGTATATGACCTTTAATTTCTTTTTTATTTTAAATATACTGTCACACTGAAGCACTGGTTGGGCATTTTAATTCATGTTAATAAATCACA ATTATGTCAGTTTTA

refseq_MLL5.F2 (forward primer)
refseq_MLL5.R2 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

RRHFPRARGSDTERAQGAESETVPEFGSGNRVG IDTPSSLAVVSAFLLTAWLPPPLLLGSW*RGCAL LFGEGVCGAGSCVRSGCCRGVACSRRCGETPWG SSTVAGMPQCFGYQCIGLHSNRIYQRRTS*A** SHWGLIQQRRHTWKWLQVQNQNP*KLALW*LRNP TVIPTSYIPAAHIIHTVTLVCPMRTIIMVLVLL RHLRLPLLHQSLLAKMK*AYLPLLILMKLPVLL QSAHLRMEVMVLM*PGAYVVLHMMMDT*SVVTNA AFGNILTAWGLIGSIFLIHIYVNVVSLGIWIKR GQCYYNAGKGKICQMVIPVQLRVVMRFLWNYIL HFSILQHQLL*LLQEFPKLMIKEGKKAGRKNNTF QNVKRHFVKDLGSHQELRVQLQRLILHLMVQIL DGRQRSKHGWIDMKKQITTSTVRVFRGRHKE*L *D*AMEMTKKR*INPI*IPTICSSNLL*RAIYKR IRKFLNLQKICLLMHLSLNTEGSLC*ENSLKQM GISLKDHTLLCYSTLNFMG*KCVLMQGLLGMRL DSSGGLVHPMQR*GMKFKMEPYIFIFILYTVFQR ELKLLLPLILTMEIVSTRWTVHASKKTQSALF* NVVLNPWKISIVVMRPDGKKEKKTKIFQKKKIH KIRILLWIVKERPTK*RAQKLNKESFLH*DYQYQ IIRNQILLMI*KKKLLLVMK*KWNQRSRLQKGK GR*QEKKEKWKQFCKLLPDLKRERKEENKLWKG SAQPKLKLKLNVKIHRLSVMLKLFRNKQKKKMLA SQPLPK*IELNREKVFLGVGLTLDSSVGDTELS ACVQISSHLLLI*KLLHNKMILKILYLQ*NQKL KLH*QK*LLKLKFQHLINVLPSTPKQRSTWLMNG *VRRMRRQENLQMAFQKGLYA*LQILKC*LHNS ILYQVSLTAPMYTPLLSIILDLLHHSFQKKGEE KNLLKTFLVHARSDG*NKLWKKKIQQFYIDLIHP VKKDPEVLQSMVKIKVHYY*MTAVPFQI*LHH* KNEDFISC*IRFTQKPPHLLLPRMLHQLTPILL LWTHLLPRLHG*NQMMKLVEMVINPYIHQLPQ*L LVHQEIPCTLRIFLPQKVLQK*RDALIVKRDMT DLQPC*HWGLLEILI*LNWVCKK*RLLVIRALG VGLKSTGSVLEKRNLCQTFS*DSMQLSQLPYIKP WKRLHMTGLSPTANWTRLTLDGAQCILPG*RAL TEQELTSQ*TPT*GT*HPRISWRLEEASE*VSQ SA*CRMILEACLWKQLCFVLPKMGLYLVSDGLLM TI*STGIAHPRIHHKRKRFLY*NTVRDNVKLGK VALRQRTFHSLVYHPMQVEA*ATMVMAVPAVMT MGSRWTTLLAYLYQHQLQFIMPLLKKLAITALLR MLLLVRRMNQKFNGLPQLQWNKSEKGVIRELYF SVITEKIKIVGENHHVSHVHRVMFSLHLHLIQI TYPSCKLRAQSLLSVNLWKTLILKIQNPQLRMNV HPQILLKILVKVLQK*ASLVHLDL*FLLKHTGK YSQNQIPNGTPQLVHPKLKMVFT*KQSSNKNSY QITTKHFQRIILLRHTFVIHLSNFHKSCLLCQQS CTVLHHLT*KILQSHPRLTHLYSMVIFHQSLLH SS*DLPTGLIIHSHLKLEHLSESLKETFIQQHR TFQPILSRQLLEHYLHRHPQDNLQQHTVSLTNKV *TARHHPLHLLHLLLRLTIKTSSPLQTFRIIIS SKVVFLNKLCLHQDQIKHFLAPQASKQFQDTT* LQGIFCPLRTLPFTIKLLLP*SPLLLHHHLLQDR TLYNSRIPISNTL*HM**GLFMRSPLGRIFILK LLDTTYPHPHPLLVLPLITIHHPIHPQDSKVYK HNTSML*IQHPHHPLRRHLPVFWLLGIIPHQLKP YTTHLIKDLHFFLRVLIQLYHRIPHKLHIIPLW DRDPSTSLLEQGHIVHYLSQVLISSPKDQTVFQ HLLLQGSVLILALWPCHMGFKDLSRHLQCLDRFQ FTEHRCHQHFKTITMGQGGIKMDSKNIFLNVL* DKLYISYVPVKVLFKACT*TFV*KTPVLFRCIF LIFAF*NSFKKCAVKPVLGIFIL*VNIPAVFFWQ I*C*FDAV*SFFFF*LNSFSECSIILYIHIKYS AK*WHYEDFFFLSCQQQFCECILGIKMQYRFLY FGVDMAHFVLPVICKQNVI*CIDDF*CLLTNCKY CISFAYIIAYSFSHLIYSIVHMTSLLQNCVIFV KVVQYMTFNFFFILNILSH*STGWAF*FMLINH NYVSF

Frame 1

AAIFPEREAVTLSGRRGPSRRPCRSSGAATEWA *TLRAASPSSLRSC*LPGCPLPYSSVPGEEAAR CCLGRGCVEPGPVSAVAAVGGSPVRGGAERLLGG RALWLACPSVLDTNA*DSIVIEFTRGERHEHSD PIGG*YSRDVILGNGCRFRTRIRRS*PCGS*EI QQLSPPVIYQQLTSFTQLHWFALCGP*LWCSSSS DTSGFPSSISPY*QK*SRHIYHS*F**NFQCYY NQHI*GWKLWY*CNQVHMWFYT**WIHDLL*QM QRLATY*LHGD**AAYS*YISM*TLSA*EFG*RE GSATTTPEKGKYVRW*YQCN*EW**GSCGIIYC ISAYSNINYFNCFKSFQS***KKEKKRGERTTH FKM*KGIS*RI*EVIKS*GFSSRD*SFI*WFKFW MGDKDQSMDGSI*RSK*QPVQ*GCSEGGTKNSS EIRQWK*QKRDE*IRFEYQQFALQTSCREPYTK E*ENS*ICKRFAS*CTYH*IQREVYAERTV*SKW VFL*KTIPFCVILL*ISWARNVC*CKDFWE*GS IHQAVLYTQCRGEA*NSRWNHTSLYLFYTQYSK GN*NYYCL*F*LWKL*VQGGLCMPQRKPRVPCSK T*F*IHGKYQ*WL*DQTEKRKKRQRYFKRKRYT KSEYYFGL*RNDQQNEEPRN*TKKAFSTETISI K*SGTRFY**YRRKNSY***SRNGIRGADCRKEK EDDKRRKKNGSNFASFCQT*KEREKKRTSFGKD QHSQN*S*N*M*RYTDCQ*C*SYSGTSKRRKC* QANPCQSK*N*TEKKFFSE*DSHWTAASETQNCQ HVFRYPAIFS*YRSYFTTK*Y*KYCTYNRTRN* NCTSRNNY*N*SSST**MSYQVPQNKEALG**M VK*EE*EDRKTFRWPFRKASTHNYRS*SVSYTTQ FFTRSHLQPPCILHS*ALY*IYFTIPFRKKEKK RTY*KHFWFMQEAMVETSSGRRKFSNFT*I*FT LSRKIQKSCSQW*K*KSTTIK*QLFPSRFNYTTK KTKILSVARFGLLRNLHTYSFPVCYTNSHRYYS YGPIFCHASTDKIR**NL*KWL*THIFTSYPSN SWYTRKYHAL*EYFFPRKFSRNKETHL*SRGI*Q IFNHVNIGAF*KF*FN*TGSARNKDYWLYEP*E *D*SQQAVSWRKGTCVRPSARTRCS*ANCPT*N PGNACT*QG*AQQPTGLDSLWTGHNVFFLGKEP* QNRS*LLSELQLEGPDTLASVGGWRRLPNK*VK VPDAG*Y*RHVYGNNCVLYFRRWACIWFRTDC* *QFDRRELHTPESTTKEKGFSIRIP*ETT*S*EK WL*DRELSTH*CITPCKWKLEQQW*WLCQQ**Q WGAGGPHC*PTFTNTSYSL*CHF*RN*Q*LPC* GCYC**EE*TRSSMDCLNFSGTSQRKELSESFTS Q*SPKR*R*WGRITMCLMFTESCSVFTFISFKS HTPVAS*GPSPFFQ*TYGRP*S*KSRTHNYE*M SIPRYFSKYL*KSSKNEQAWFTWICNSCSSTREN IHKTRSPMGLHS*CIRS*KWCSPKNRAPTKTAI K*QPSTFKESSSSDTRS*FI*ATFTKAAFCANK VALSSITSPRKSSKVIHASHTCTAWLSFTKASFT AVRISLQASSFTVTSSWNTSARASKKLLSSSTE PSSQYSAGNFWNIIYTDTLRTIFSNIQSV*PTK SEQHGTTPSTSSTSFFVLLSKPAALCKLSEL*SA QR*SFSTNCVYIRTKSSTSWHHKPANSSRTPRD SRAFFALSEPYHSPSNCCCRSPPSSSTTTCSRT APCTTAEFPSATLCSTCSRACSCGHPWVAYSFSN CWTPLTPTPTPSWSCPSSPSTTPSIHRTPRSTS TTPACCKFSTPTTPSAATFQCFGFWASYHISSS LTPPTSSRTSTFSFECSSNCTTVSLTSYTSYHFG TGTPAPAFWNRATLSITCHRSSSPAPRTKQYSN TYCFRVLSSSWLCGPATWGSRTSAGISSAWTDS NSQSTGATNISKQLPWVRVALKWTPKTFF*MFCK INCIFHMYLLRYFLKLVHEPLYKKHQCSFVVFF SFLLFKIPLKNVLLSQY*VSLFCK*TFQLFFSG RSDADLMLYDLFFFFS*IHLVNVLLFYTYTLSTQ LSNGTMRIFFFFPVSSSSVNAS*V*KCNTDFYI LVWTWLILFYQLFASKM*FNV*MISNVS*QTVN TAFLLRI*LLTAFLI*YIALYI*QVFCKTV*SL* K*YSI*PLISFLF*IYCHTEALVGHFNSC**IT IMSVL

Frame 2

PPFSQSERQ*H*AGAGGRVGDRAGVRERQQSGH RHSEQPRRRLCVPVDCLAAPSPTPRFLVKRLRA AVWGGGVWSRVLCPQWLLSGGRLFAEVRRDSLG VEHCGWHAPVFWIPMHRTP**SNLPEANVMSIVI PLGVDTAETSYLEMAAGSEPESVEASPVVVEKS NSYPHQLYTSSSHHSHSYIGLPYADHNYGARPP PTPPASPPPSVLISKNEVGIFTTPNFDETSSATT ISTSEDGSYGTDVTRCICGFTHDDGYMICCDKC SVWQHIDCMGIDRQHIPDTYLCERCQPRNLDKE RAVLLQRRKRENMSDGDTSATESGDEVPVELYTA FQHTPTSITLTASRVSKVNDKRRKKSGEKEQHI SKCKKAFREGSRKSSRVKGSAPEIDPSSDGSNF GWETKIKAWMDRYEEANNNQYSEGVQREAQRIAL RLGNGNDKKEMNKSDLNTNNLLFKPPVESHIQK NKKILKSAKDLPPDALIIEYRGKFMLREQFEAN GYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEAR FIRRSCTPNAEVRHEIQDGTIHLYIYSIHSIPK GTEITIAFDFDYGNCKYKVDCACLKENPECPVL KRSSESMENINSGYETRRKKGKKDKDISKEKDTQ NQNITLDCEGTTNKMKSPETKQRKLSPLRLSVS NNQEPDFIDDIEEKTPISNEVEMESEEQIAERK RKMTREERKMEAILQAFARLEKREKRREQALERI STAKTEVKTECKDTQIVSDAEVIQEQAKEENAS KPTPAKVNRTKQRKSFSRSRTHIGQQRRRHRTV SMCSDIQPSSPDIEVTSQQNDIENTVLTIEPETE TALAEIITETEVPALNKCPTKYPKTKKHLVNEW LSEKNEKTGKPSDGLSERPLRITTDPEVLATQL NSLPGLTYSPHVYSTPKHYIRFTSPFLSEKRRRK EPTENISGSCKKRWLKQALEEENSAILHRFNSP CQERSRSPAVNGENKSPLLLNDSCSLPDLTTPL KKRRFYQLLDSVYSETSTPTPSPYATPTHTDITP MDPSFATPPRIKSDDETCRNGYKPIYSPVTPVT PGTPGNTMHFENISSPESSPEIKRRTYSQEGYD RSSTMLTLGPFRNSNLTELGLQEIKTIGYTSPRS RTEVNRQCPGEKEPVSDLQLGLDAVEPTALHKT LETPAHDRAEPNSQLDSTHSGRGTMYSSWVKSP DRTGVNFSVNSNLRDLTPSHQLEVGGGFRISESK CLMQDDTRGMFMETTVFCTSEDGLVSGFGRTVN DNLIDGNCTPQNPPQKKKVSLLEYRKRQREARK SGSKTENFPLISVSPHASGSLSNNGDGCASSNDN GEQVDHTASLPLPTPATVYNATSEETSNNCPVK DATASEKNEPEVQWTASTSVEQVRERSYQRALL LSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNH IPQLQAKGPVPSFSELMEDPDPENPEPTTTNEC PSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGK IFTKPDPQWDSTVSASEAENGVHLKTELQQKQLS NNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTK LHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPS QQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQN LPANTQQATSGTLFTQTPSGQSSATYSQFNQQS LNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQ LKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVT PGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGP HLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQ TAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQA QHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQA LHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTL GPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPT PTASGFCPHPGSVALPHGVQGPQQASPVPGQIP IHRAQVPPTFQNNYHGSGWH*NGLQKHFFKCSV R*TVYFICTC*GTF*SLYMNLCIKNTSALSLYFS HFCFLKFL*KMCC*ASIRYLYFVSEHSSCFFLA DLMLI*CCMIFFFFLVKFI**MFYYFIHTH*VL S*VMAL*GFFFSFLSAAVL*MHLRYKNAIQIFIF WCGHGSFCFTSYLQAKCNLMYR*FLMSPDKL*I LHFFCVYNCLQLFSFDI*HCTYDKSFAKLCDLC ESSTVYDL*FLFYFKYTVTLKHWLGILIHVNKSQ LCQF

Sequence NM_182931

CGCCGCCATTTTCCCAGAGCGAGAGGCAGTGACACTGAGCGGGCGCAGGGGGCCGAGTCGGAGACCGTGCCGGAGTTCGGGAGCGGCAACAGAGTGGGCA TAGACACTCCGAGCAGCCTCGCCGTCGTCTCTGCGTTCCTGTTGACTGCCTGGCTGCCCCCTCCCCTACTCCTCGGTTCCTGGTGAAGAGGCTGCGCGCT GCTGTTTGGGGAGGGGGTGTGTGGAGCCGGGTCCTGTGTCCGCAGTGGCTGCTGTCGGGGGGTCGCCTGTTCGCGGAGGTGCGGAGAGACTCCTTGGGGG TCGAGCACATAACGGGGTTCGGGTGTCTCGTGTGTGAACATCACAGGTCTATTCTGGATAAGCAGGTTTTGTGAAGACATTTATTCTTTCTTGGACCTCA GATTTACCAGACATCTCATGGGTTTGTGGATGCACTTAGATGTTTGCAATGAGCACTGTGGCTGGCATGCCCCAGTGTTTTGGATACCAATGCATAGGAC TCCATAGTAATCGAATTTACCAGAGGCGAACGTCATGAGCATAGTGATCCCATTGGGGGTTGATACAGCAGAGACGTCATACTTGGAAATGGCTGCAGGT TCAGAACCAGAATCCGTAGAAGCTAGCCCTGTGGTAGTTGAGAAATCCAACAGTTATCCCCACCAGTTATATACCAGCAGCTCACATCATTCACACAGTT ACATTGGTTTGCCCTATGCGGACCATAATTATGGTGCTCGTCCTCCTCCGACACCTCCGGCTTCCCCTCCTCCATCAGTCCTTATTAGCAAAAATGAAGT AGGCATATTTACCACTCCTAATTTTGATGAAACTTCCAGTGCTACTACAATCAGCACATCTGAGGATGGAAGTTATGGTACTGATGTAACCAGGTGCATA TGTGGTTTTACACATGATGATGGATACATGATCTGTTGTGACAAATGCAGCGTTTGGCAACATATTGACTGCATGGGGATTGATAGGCAGCATATTCCTG ATACATATCTATGTGAACGTTGTCAGCCTAGGAATTTGGATAAAGAGAGGGCAGTGCTACTACAACGCCGGAAAAGGGAAAATATGTCAGATGGTGATAC CAGTGCAACTGAGAGTGGTGATGAGGTTCCTGTGGAATTATATACTGCATTTCAGCATACTCCAACATCAATTACTTTAACTGCTTCAAGAGTTTCCAAA GTTAATGATAAAAGAAGGAAAAAAAGCGGGGAGAAAGAACAACACATTTCAAAATGTAAAAAGGCATTTCGTGAAGGATCTAGGAAGTCATCAAGAGTTA AGGGTTCAGCTCCAGAGATTGATCCTTCATCTGATGGTTCAAATTTTGGATGGGAGACAAAGATCAAAGCATGGATGGATCGATATGAAGAAGCAAATAA CAACCAGTACAGTGAGGGTGTTCAGAGGGAGGCACAAAGAATAGCTCTGAGATTAGGCAATGGAAATGACAAAAAAGAGATGAATAAATCCGATTTGAAT ACCAACAATTTGCTCTTCAAACCTCCTGTAGAGAGCCATATACAAAAGAATAAGAAAATTCTTAAATCTGCAAAAGATTTGCCTCCTGATGCACTTATCA TTGAATACAGAGGGAAGTTTATGCTGAGAGAACAGTTTGAAGCAAATGGGTATTTCTTTAAAAGACCATACCCTTTTGTGTTATTCTACTCTAAATTTCA TGGGCTAGAAATGTGTGTTGATGCAAGGACTTTTGGGAATGAGGCTCGATTCATCAGGCGGTCTTGTACACCCAATGCAGAGGTGAGGCATGAAATTCAA GATGGAACCATACATCTTTATATTTATTCTATACACAGTATTCCAAAGGGAACTGAAATTACTATTGCCTTTGATTTTGACTATGGAAATTGTAAGTACA AGGTGGACTGTGCATGCCTCAAAGAAAACCCAGAGTGCCCTGTTCTAAAACGTAGTTCTGAATCCATGGAAAATATCAATAGTGGTTATGAGACCAGACG GAAAAAAGGAAAAAAAGACAAAGATATTTCAAAAGAAAAAGATACACAAAATCAGAATATTACTTTGGATTGTGAAGGAACGACCAACAAAATGAAGAGC CCAGAAACTAAACAAAGAAAGCTTTCTCCACTGAGACTATCAGTATCAAATAATCAGGAACCAGATTTTATTGATGATATAGAAGAAAAAACTCCTATTA GTAATGAAGTAGAAATGGAATCAGAGGAGCAGATTGCAGAAAGGAAAAGGAAGATGACAAGAGAAGAAAGAAAAATGGAAGCAATTTTGCAAGCTTTTGC CAGACTTGAAAAGAGAGAGAAAAGAAGAGAACAAGCTTTGGAAAGGATCAGCACAGCCAAAACTGAAGTTAAAACTGAATGTAAAGATACACAGATTGTC AGTGATGCTGAAGTTATTCAGGAACAAGCAAAAGAAGAAAATGCTAGCAAGCCAACCCCTGCCAAAGTAAATAGAACTAAACAGAGAAAAAGTTTTTCTC GGAGTAGGACTCACATTGGACAGCAGCGTCGGAGACACAGAACTGTCAGCATGTGTTCAGATATCCAGCCATCTTCTCCTGATATAGAAGTTACTTCACA ACAAAATGATATTGAAAATACTGTACTTACAATAGAACCAGAAACTGAAACTGCACTAGCAGAAATAATTACTGAAACTGAAGTTCCAGCACTTAATAAA TGTCCTACCAAGTACCCCAAAACAAAGAAGCACTTGGTTAATGAATGGTTAAGTGAGAAGAATGAGAAGACAGGAAAACCTTCAGATGGCCTTTCAGAAA GGCCTCTACGCATAACTACAGATCCTGAAGTGTTAGCTACACAACTCAATTCTTTACCAGGTCTCACTTACAGCCCCCATGTATACTCCACTCCTAAGCA TTATATTAGATTTACTTCACCATTCCTTTCAGAAAAAAGGAGAAGAAAAGAACCTACTGAAAACATTTCTGGTTCATGCAAGAAGCGATGGTTGAAACAA GCTCTGGAAGAAGAAAATTCAGCAATTTTACATAGATTTAATTCACCCTGTCAAGAAAGATCCAGAAGTCCTGCAGTCAATGGTGAAAATAAAAGTCCAC TACTATTAAATGACAGCTGTTCCCTTCCAGATTTAACTACACCACTAAAAAAACGAAGATTTTATCAGTTGCTAGATTCGGTTTACTCAGAAACCTCCAC ACCTACTCCTTCCCCGTATGCTACACCAACTCACACCGATATTACTCCTATGGACCCATCTTTTGCCACGCCTCCACGGATAAAATCAGATGATGAAACT TGTAGAAATGGTTATAAACCCATATATTCACCAGTTACCCCAGTAACTCCTGGTACACCAGGAAATACCATGCACTTTGAGAATATTTCTTCCCCAGAAA GTTCTCCAGAAATAAAGAGACGCACTTATAGTCAAGAGGGATATGACAGATCTTCAACCATGTTAACATTGGGGCCTTTTAGAAATTCTAATTTAACTGA ACTGGGTCTGCAAGAAATAAAGACTATTGGTTATACGAGCCCTAGGAGTAGGACTGAAGTCAACAGGCAGTGTCCTGGAGAAAAGGAACCTGTGTCAGAC CTTCAGCTAGGACTCGATGCAGTTGAGCCAACTGCCCTACATAAAACCCTGGAAACGCCTGCACATGACAGGGCTGAGCCCAACAGCCAACTGGACTCGA CTCACTCTGGACGGGGCACAATGTATTCTTCCTGGGTAAAGAGCCCTGACAGAACAGGAGTTAACTTCTCAGTGAACTCCAACTTGAGGGACCTGACACC CTCGCATCAGTTGGAGGTTGGAGGAGGCTTCCGAATAAGTGAGTCAAAGTGCCTGATGCAGGATGATACTAGAGGCATGTTTATGGAAACAACTGTGTTT TGTACTTCCGAAGATGGGCTTGTATCTGGTTTCGGACGGACTGTTAATGACAATTTGATCGACGGGAATTGCACACCCCAGAATCCACCACAAAAGAAAA AGGTTTCTCTATTAGAATACCGTAAGAGACAACGTGAAGCTAGGAAAAGTGGCTCTAAGACAGAGAACTTTCCACTCATTAGTGTATCACCCCATGCAAG TGGAAGCTTGAGCAACAATGGTGATGGCTGTGCCAGCAGTAATGACAATGGGGAGCAGGTGGACCACACTGCTAGCCTACCTTTACCAACACCAGCTACA GTTTATAATGCCACTTCTGAAGAAACTAGCAATAACTGCCCTGTTAAGGATGCTACTGCTAGTGAGAAGAATGAACCAGAAGTTCAATGGACTGCCTCAA CTTCAGTGGAACAAGTCAGAGAAAGGAGTTATCAGAGAGCTTTACTTCTCAGTGATCACCGAAAAGATAAAGATAGTGGGGGAGAATCACCATGTGTCTC ATGTTCACCGAGTCATGTTCAGTCTTCACCTTCATCTCATTCAAATCACATACCCCAGTTGCAAGCTAAGGGCCCAGTCCCTTCTTTCAGTGAACTTATG GAAGACCCTGATCCTGAAAATCCAGAACCCACAACTACGAATGAATGTCCATCCCCAGATACTTCTCAAAATACTTGTAAAAGTCCTCCAAAAATGAGCA AGCCTGGTTCACCTGGATCTGTAATTCCTGCTCAAGCACACGGGAAAATATTCACAAAACCAGATCCCCAATGGGACTCCACAGTTAGTGCATCCGAAGC TGAAAATGGTGTTCACCTAAAAACAGAGCTCCAACAAAAACAGCTATCAAATAACAACCAAGCACTTTCAAAGAATCATCCTCCTCAGACACACGTTCGT AATTCATCTGAGCAACTTTCACAAAAGCTGCCTTCTGTGCCAACAAAGTTGCACTGTCCTCCATCACCTCACCTAGAAAATCCTCCAAAGTCATCCACGC CTCACACACCTGTACAGCATGGTTATCTTTCACCAAAGCCTCCTTCACAGCAGTTAGGATCTCCCTACAGGCCTCATCATTCACAGTCACCTCAAGTTGG AACACCTCAGCGAGAGCCTCAAAGAAACTTTTATCCAGCAGCACAGAACCTTCCAGCCAATACTCAGCAGGCAACTTCTGGAACATTATTTACACAGACA CCCTCAGGACAATCTTCAGCAACATACAGTCAGTTTAACCAACAAAGTCTGAACAGCACGGCACCACCCCCTCCACCTCCTCCACCTCCTTCTTCGTCTT ACTATCAAAACCAGCAGCCCTCTGCAAACTTTCAGAATTATAATCAGCTCAAAGGTAGTCTTTCTCAACAAACTGTGTTTACATCAGGACCAAATCAAGC ACTTCCTGGCACCACAAGCCAGCAAACAGTTCCAGGACACCACGTGACTCCAGGGCATTTTTTGCCCTCTCAGAACCCTACCATTCACCATCAAACTGCT GCTGCCGTAGTCCCCCCTCCTCCTCCACCACCACCTGCTCCAGGACCGCACCTTGTACAACAGCCGAATTCCCATCAGCAACACTCTGTAGCACATGTAG TAGGGCCTGTTCATGCGGTCACCCCTGGGTCGCATATTCATTCTCAAACTGCTGGACACCACTTACCCCCACCCCCACCCCCTCCTGGTCCTGCCCCTCA TCACCATCCACCACCCCATCCATCCACAGGACTCCAAGGTCTACAAGCACAACACCAGCATGTTGTAAATTCAGCACCCCCACCACCCCCTCCGCCGCCA CCTTCCAGTGTTTTGGCTTCTGGGCATCATACCACATCAGCTCAAGCCTTACACCACCCACCTCATCAAGGACCTCCACTTTTTCCTTCGAGTGCTCATC CAACTGTACCACCGTATCCCTCACAAGCTACACATCATACCACTTTGGGACCGGGACCCCAGCACCAGCCTTCTGGAACAGGGCCACATTGTCCATTACC TGTCACAGGTCCTCATCTCCAGCCCCAAGGACCAAACAGTATTCCAACACCTACTGCTTCAGGGTTCTGTCCTCATCCTGGCTCTGTGGCCCTGCCACAT GGGGTTCAAGGACCTCAGCAGGCATCTCCAGTGCCTGGACAGATTCCAATTCACAGAGCACAGGTGCCACCAACATTTCAAAACAATTACCATGGGTCAG GGTGGCATTAAAATGGACTCCAAAAACATTTTTTTAAATGTTCTGTAAGATAAACTGTATATTTCATATGTACCTGTTAAGGTACTTTTTAAAGCTTGTA CATGAACCTTTGTATAAAAAACACCAGTGCTCTTTCGTTGTATTTTTCTCATTTTTGCTTTTTAAAATTCCTTTAAAAAATGTGCTGTTAAGCCAGTATT AGGTATCTTTATTTTGTAAGTGAACATTCCAGCTGTTTTTTTCTGGCAGATCTGATGCTGATTTGATGCTGTATGATCTTTTTTTTTTTTTTAGTTAAAT TCATTTAGTGAATGTTCTATTATTTTATACATACACATTAAGTACTCAGCTAAGTAATGGCACTATGAGGATTTTTTTTTTCTTTCCTGTCAGCAGCAGT TCTGTGAATGCATCTTAGGTATAAAAATGCAATACAGATTTTTATATTTTGGTGTGGACATGGCTCATTTTGTTTTACCAGTTATTTGCAAGCAAAATGT AATTTAATGTATAGATGATTTCTAATGTCTCCTGACAAACTGTAAATACTGCATTTCTTTTGCGTATATAATTGCTTACAGCTTTTCTCATTTGATATAT AGCATTGTACATATGACAAGTCTTTTGCAAAACTGTGTGATCTTTGTGAAAGTAGTACAGTATATGACCTTTAATTTCTTTTTTATTTTAAATATACTGT CACACTGAAGCACTGGTTGGGCATTTTAATTCATGTTAATAAATCACAATTATGTCAGTTTTA

refseq_MLL5.F2 (forward primer)
refseq_MLL5.R2 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

RRHFPRARGSDTERAQGAESETVPEFGSGNRVG IDTPSSLAVVSAFLLTAWLPPPLLLGSW*RGCAL LFGEGVCGAGSCVRSGCCRGVACSRRCGETPWG SST*RGSGVSCVNITGLFWISRFCEDIYSFLDL RFTRHLMGLWMHLDVCNEHCGWHAPVFWIPMHRT P**SNLPEANVMSIVIPLGVDTAETSYLEMAAG SEPESVEASPVVVEKSNSYPHQLYTSSSHHSHS YIGLPYADHNYGARPPPTPPASPPPSVLISKNEV GIFTTPNFDETSSATTISTSEDGSYGTDVTRCI CGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIP DTYLCERCQPRNLDKERAVLLQRRKRENMSDGDT SATESGDEVPVELYTAFQHTPTSITLTASRVSK VNDKRRKKSGEKEQHISKCKKAFREGSRKSSRV KGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANN NQYSEGVQREAQRIALRLGNGNDKKEMNKSDLN TNNLLFKPPVESHIQKNKKILKSAKDLPPDALI IEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFH GLEMCVDARTFGNEARFIRRSCTPNAEVRHEIQ DGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKY KVDCACLKENPECPVLKRSSESMENINSGYETRR KKGKKDKDISKEKDTQNQNITLDCEGTTNKMKS PETKQRKLSPLRLSVSNNQEPDFIDDIEEKTPI SNEVEMESEEQIAERKRKMTREERKMEAILQAFA RLEKREKRREQALERISTAKTEVKTECKDTQIV SDAEVIQEQAKEENASKPTPAKVNRTKQRKSFS RSRTHIGQQRRRHRTVSMCSDIQPSSPDIEVTSQ QNDIENTVLTIEPETETALAEIITETEVPALNK CPTKYPKTKKHLVNEWLSEKNEKTGKPSDGLSE RPLRITTDPEVLATQLNSLPGLTYSPHVYSTPKH YIRFTSPFLSEKRRRKEPTENISGSCKKRWLKQ ALEEENSAILHRFNSPCQERSRSPAVNGENKSP LLLNDSCSLPDLTTPLKKRRFYQLLDSVYSETST PTPSPYATPTHTDITPMDPSFATPPRIKSDDET CRNGYKPIYSPVTPVTPGTPGNTMHFENISSPE SSPEIKRRTYSQEGYDRSSTMLTLGPFRNSNLTE LGLQEIKTIGYTSPRSRTEVNRQCPGEKEPVSD LQLGLDAVEPTALHKTLETPAHDRAEPNSQLDS THSGRGTMYSSWVKSPDRTGVNFSVNSNLRDLTP SHQLEVGGGFRISESKCLMQDDTRGMFMETTVF CTSEDGLVSGFGRTVNDNLIDGNCTPQNPPQKK KVSLLEYRKRQREARKSGSKTENFPLISVSPHAS GSLSNNGDGCASSNDNGEQVDHTASLPLPTPAT VYNATSEETSNNCPVKDATASEKNEPEVQWTAS TSVEQVRERSYQRALLLSDHRKDKDSGGESPCVS CSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELM EDPDPENPEPTTTNECPSPDTSQNTCKSPPKMS KPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEA ENGVHLKTELQQKQLSNNNQALSKNHPPQTHVR NSSEQLSQKLPSVPTKLHCPPSPHLENPPKSST PHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVG TPQREPQRNFYPAAQNLPANTQQATSGTLFTQT PSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSS YYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQA LPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTA AAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHV VGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPH HHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPP PSSVLASGHHTTSAQALHHPPHQGPPLFPSSAH PTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLP VTGPHLQPQGPNSIPTPTASGFCPHPGSVALPH GVQGPQQASPVPGQIPIHRAQVPPTFQNNYHGS GWH*NGLQKHFFKCSVR*TVYFICTC*GTF*SLY MNLCIKNTSALSLYFSHFCFLKFL*KMCC*ASI RYLYFVSEHSSCFFLADLMLI*CCMIFFFFLVK FI**MFYYFIHTH*VLS*VMAL*GFFFSFLSAAV L*MHLRYKNAIQIFIFWCGHGSFCFTSYLQAKC NLMYR*FLMSPDKL*ILHFFCVYNCLQLFSFDI *HCTYDKSFAKLCDLCESSTVYDL*FLFYFKYTV TLKHWLGILIHVNKSQLCQF

Frame 1

AAIFPEREAVTLSGRRGPSRRPCRSSGAATEWA *TLRAASPSSLRSC*LPGCPLPYSSVPGEEAAR CCLGRGCVEPGPVSAVAAVGGSPVRGGAERLLGG RAHNGVRVSRV*TSQVYSG*AGFVKTFILSWTS DLPDISWVCGCT*MFAMSTVAGMPQCFGYQCIG LHSNRIYQRRTS*A**SHWGLIQQRRHTWKWLQV QNQNP*KLALW*LRNPTVIPTSYIPAAHIIHTV TLVCPMRTIIMVLVLLRHLRLPLLHQSLLAKMK *AYLPLLILMKLPVLLQSAHLRMEVMVLM*PGAY VVLHMMMDT*SVVTNAAFGNILTAWGLIGSIFL IHIYVNVVSLGIWIKRGQCYYNAGKGKICQMVI PVQLRVVMRFLWNYILHFSILQHQLL*LLQEFPK LMIKEGKKAGRKNNTFQNVKRHFVKDLGSHQEL RVQLQRLILHLMVQILDGRQRSKHGWIDMKKQI TTSTVRVFRGRHKE*L*D*AMEMTKKR*INPI*I PTICSSNLL*RAIYKRIRKFLNLQKICLLMHLS LNTEGSLC*ENSLKQMGISLKDHTLLCYSTLNF MG*KCVLMQGLLGMRLDSSGGLVHPMQR*GMKFK MEPYIFIFILYTVFQRELKLLLPLILTMEIVST RWTVHASKKTQSALF*NVVLNPWKISIVVMRPD GKKEKKTKIFQKKKIHKIRILLWIVKERPTK*RA QKLNKESFLH*DYQYQIIRNQILLMI*KKKLLL VMK*KWNQRSRLQKGKGR*QEKKEKWKQFCKLL PDLKRERKEENKLWKGSAQPKLKLKLNVKIHRLS VMLKLFRNKQKKKMLASQPLPK*IELNREKVFL GVGLTLDSSVGDTELSACVQISSHLLLI*KLLH NKMILKILYLQ*NQKLKLH*QK*LLKLKFQHLIN VLPSTPKQRSTWLMNG*VRRMRRQENLQMAFQK GLYA*LQILKC*LHNSILYQVSLTAPMYTPLLS IILDLLHHSFQKKGEEKNLLKTFLVHARSDG*NK LWKKKIQQFYIDLIHPVKKDPEVLQSMVKIKVH YY*MTAVPFQI*LHH*KNEDFISC*IRFTQKPP HLLLPRMLHQLTPILLLWTHLLPRLHG*NQMMKL VEMVINPYIHQLPQ*LLVHQEIPCTLRIFLPQK VLQK*RDALIVKRDMTDLQPC*HWGLLEILI*L NWVCKK*RLLVIRALGVGLKSTGSVLEKRNLCQT FS*DSMQLSQLPYIKPWKRLHMTGLSPTANWTR LTLDGAQCILPG*RALTEQELTSQ*TPT*GT*H PRISWRLEEASE*VSQSA*CRMILEACLWKQLCF VLPKMGLYLVSDGLLMTI*STGIAHPRIHHKRK RFLY*NTVRDNVKLGKVALRQRTFHSLVYHPMQ VEA*ATMVMAVPAVMTMGSRWTTLLAYLYQHQLQ FIMPLLKKLAITALLRMLLLVRRMNQKFNGLPQ LQWNKSEKGVIRELYFSVITEKIKIVGENHHVS HVHRVMFSLHLHLIQITYPSCKLRAQSLLSVNLW KTLILKIQNPQLRMNVHPQILLKILVKVLQK*A SLVHLDL*FLLKHTGKYSQNQIPNGTPQLVHPK LKMVFT*KQSSNKNSYQITTKHFQRIILLRHTFV IHLSNFHKSCLLCQQSCTVLHHLT*KILQSHPR LTHLYSMVIFHQSLLHSS*DLPTGLIIHSHLKL EHLSESLKETFIQQHRTFQPILSRQLLEHYLHRH PQDNLQQHTVSLTNKV*TARHHPLHLLHLLLRL TIKTSSPLQTFRIIISSKVVFLNKLCLHQDQIK HFLAPQASKQFQDTT*LQGIFCPLRTLPFTIKLL LP*SPLLLHHHLLQDRTLYNSRIPISNTL*HM* *GLFMRSPLGRIFILKLLDTTYPHPHPLLVLPL ITIHHPIHPQDSKVYKHNTSML*IQHPHHPLRRH LPVFWLLGIIPHQLKPYTTHLIKDLHFFLRVLI QLYHRIPHKLHIIPLWDRDPSTSLLEQGHIVHY LSQVLISSPKDQTVFQHLLLQGSVLILALWPCHM GFKDLSRHLQCLDRFQFTEHRCHQHFKTITMGQ GGIKMDSKNIFLNVL*DKLYISYVPVKVLFKAC T*TFV*KTPVLFRCIFLIFAF*NSFKKCAVKPVL GIFIL*VNIPAVFFWQI*C*FDAV*SFFFF*LN SFSECSIILYIHIKYSAK*WHYEDFFFLSCQQQ FCECILGIKMQYRFLYFGVDMAHFVLPVICKQNV I*CIDDF*CLLTNCKYCISFAYIIAYSFSHLIY SIVHMTSLLQNCVIFVKVVQYMTFNFFFILNIL SH*STGWAF*FMLINHNYVSF

Frame 2

PPFSQSERQ*H*AGAGGRVGDRAGVRERQQSGH RHSEQPRRRLCVPVDCLAAPSPTPRFLVKRLRA AVWGGGVWSRVLCPQWLLSGGRLFAEVRRDSLG VEHITGFGCLVCEHHRSILDKQVL*RHLFFLGPQ IYQTSHGFVDALRCLQ*ALWLACPSVLDTNA*D SIVIEFTRGERHEHSDPIGG*YSRDVILGNGCR FRTRIRRS*PCGS*EIQQLSPPVIYQQLTSFTQL HWFALCGP*LWCSSSSDTSGFPSSISPY*QK*S RHIYHS*F**NFQCYYNQHI*GWKLWY*CNQVH MWFYT**WIHDLL*QMQRLATY*LHGD**AAYS* YISM*TLSA*EFG*REGSATTTPEKGKYVRW*Y QCN*EW**GSCGIIYCISAYSNINYFNCFKSFQ S***KKEKKRGERTTHFKM*KGIS*RI*EVIKS* GFSSRD*SFI*WFKFWMGDKDQSMDGSI*RSK* QPVQ*GCSEGGTKNSSEIRQWK*QKRDE*IRFE YQQFALQTSCREPYTKE*ENS*ICKRFAS*CTYH *IQREVYAERTV*SKWVFL*KTIPFCVILL*IS WARNVC*CKDFWE*GSIHQAVLYTQCRGEA*NS RWNHTSLYLFYTQYSKGN*NYYCL*F*LWKL*VQ GGLCMPQRKPRVPCSKT*F*IHGKYQ*WL*DQT EKRKKRQRYFKRKRYTKSEYYFGL*RNDQQNEE PRN*TKKAFSTETISIK*SGTRFY**YRRKNSY* **SRNGIRGADCRKEKEDDKRRKKNGSNFASFC QT*KEREKKRTSFGKDQHSQN*S*N*M*RYTDC Q*C*SYSGTSKRRKC*QANPCQSK*N*TEKKFFS E*DSHWTAASETQNCQHVFRYPAIFS*YRSYFT TK*Y*KYCTYNRTRN*NCTSRNNY*N*SSST** MSYQVPQNKEALG**MVK*EE*EDRKTFRWPFRK ASTHNYRS*SVSYTTQFFTRSHLQPPCILHS*A LY*IYFTIPFRKKEKKRTY*KHFWFMQEAMVET SSGRRKFSNFT*I*FTLSRKIQKSCSQW*K*KST TIK*QLFPSRFNYTTKKTKILSVARFGLLRNLH TYSFPVCYTNSHRYYSYGPIFCHASTDKIR**N L*KWL*THIFTSYPSNSWYTRKYHAL*EYFFPRK FSRNKETHL*SRGI*QIFNHVNIGAF*KF*FN* TGSARNKDYWLYEP*E*D*SQQAVSWRKGTCVR PSARTRCS*ANCPT*NPGNACT*QG*AQQPTGLD SLWTGHNVFFLGKEP*QNRS*LLSELQLEGPDT LASVGGWRRLPNK*VKVPDAG*Y*RHVYGNNCV LYFRRWACIWFRTDC**QFDRRELHTPESTTKEK GFSIRIP*ETT*S*EKWL*DRELSTH*CITPCK WKLEQQW*WLCQQ**QWGAGGPHC*PTFTNTSY SL*CHF*RN*Q*LPC*GCYC**EE*TRSSMDCLN FSGTSQRKELSESFTSQ*SPKR*R*WGRITMCL MFTESCSVFTFISFKSHTPVAS*GPSPFFQ*TY GRP*S*KSRTHNYE*MSIPRYFSKYL*KSSKNEQ AWFTWICNSCSSTRENIHKTRSPMGLHS*CIRS *KWCSPKNRAPTKTAIK*QPSTFKESSSSDTRS *FI*ATFTKAAFCANKVALSSITSPRKSSKVIHA SHTCTAWLSFTKASFTAVRISLQASSFTVTSSW NTSARASKKLLSSSTEPSSQYSAGNFWNIIYTD TLRTIFSNIQSV*PTKSEQHGTTPSTSSTSFFVL LSKPAALCKLSEL*SAQR*SFSTNCVYIRTKSS TSWHHKPANSSRTPRDSRAFFALSEPYHSPSNC CCRSPPSSSTTTCSRTAPCTTAEFPSATLCSTCS RACSCGHPWVAYSFSNCWTPLTPTPTPSWSCPS SPSTTPSIHRTPRSTSTTPACCKFSTPTTPSAA TFQCFGFWASYHISSSLTPPTSSRTSTFSFECSS NCTTVSLTSYTSYHFGTGTPAPAFWNRATLSIT CHRSSSPAPRTKQYSNTYCFRVLSSSWLCGPAT WGSRTSAGISSAWTDSNSQSTGATNISKQLPWVR VALKWTPKTFF*MFCKINCIFHMYLLRYFLKLV HEPLYKKHQCSFVVFFSFLLFKIPLKNVLLSQY *VSLFCK*TFQLFFSGRSDADLMLYDLFFFFS*I HLVNVLLFYTYTLSTQLSNGTMRIFFFFPVSSS SVNAS*V*KCNTDFYILVWTWLILFYQLFASKM *FNV*MISNVS*QTVNTAFLLRI*LLTAFLI*YI ALYI*QVFCKTV*SL*K*YSI*PLISFLF*IYC HTEALVGHFNSC**ITIMSVL