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Sequences

Sequence NM_017522

GCTGGCGGCGGCCGCCCAGGGCCGGGGCCGCGCGCCCAGCCTGAGCCCGCCCCGCCGCCGAGCGTCACCGAACCTGCTTGAAATGCAGCCGAGGAGCCGG GGCGGGCGGCAGCGGCGGCGGCGGCGGCGGCGGGGGCAGCGGCAACCCCGGCGCCGCGGCAAGGACTCGGAGGGCTGAGACGCGGCGGCGGCGGCGCGGG GAGCGCGGGGCGCGGCGGCCGGAGCCCCGGGCCCGCCATGGGCCTCCCCGAGCCGGGCCCTCTCCGGCTTCTGGCGCTGCTGCTGCTGCTGCTGCTGCTG CTGCTGCTGCAGCTCCAGCATCTTGCGGCGGCAGCGGCTGATCCGCTGCTCGGCGGCCAAGGGCCGGCCAAGGATTGCGAAAAGGACCAATTCCAGTGCC GGAACGAGCGCTGCATCCCCTCTGTGTGGAGATGCGACGAGGACGATGACTGCTTAGACCACAGCGACGAGGACGACTGCCCCAAGAAGACCTGTGCAGA CAGTGACTTCACCTGTGACAACGGCCACTGCATCCACGAACGGTGGAAGTGTGACGGCGAGGAGGAGTGTCCTGATGGCTCCGATGAGTCCGAGGCCACT TGCACCAAGCAGGTGTGTCCTGCAGAGAAGCTGAGCTGTGGACCCACCAGCCACAAGTGTGTACCTGCCTCGTGGCGCTGCGACGGGGAGAAGGACTGCG AGGGTGGAGCGGATGAGGCCGGCTGTGCTACCTCACTGGGCACCTGCCGTGGGGACGAGTTCCAGTGTGGGGATGGGACATGTGTCCTTGCAATCAAGCA CTGCAACCAGGAGCAGGACTGTCCAGATGGGAGTGATGAAGCTGGCTGCCTACAGGGGCTGAACGAGTGTCTGCACAACAATGGCGGCTGCTCACACATC TGCACTGACCTCAAGATTGGCTTTGAATGCACGTGCCCAGCAGGCTTCCAGCTCCTGGACCAGAAGACCTGTGGCGACATTGATGAGTGCAAGGACCCAG ATGCCTGCAGCCAGATCTGTGTCAATTACAAGGGCTATTTTAAGTGTGAGTGCTACCCTGGCTACGAGATGGACCTACTGACCAAGAACTGCAAGGCTGC TGCTGGCAAGAGCCCATCCCTAATCTTCACCAACCGGCACGAGGTGCGGAGGATCGACCTGGTGAAGCGGAACTATTCACGCCTCATCCCCATGCTCAAG AATGTCGTGGCACTAGATGTGGAAGTTGCCACCAATCGCATCTACTGGTGTGACCTCTCCTACCGTAAGATCTATAGCGCCTACATGGACAAGGCCAGTG ACCCGAAAGAGCAGGAGGTCCTCATTGACGAGCAGTTGCACTCTCCAGAGGGCCTGGCAGTGGACTGGGTCCACAAGCACATCTACTGGACTGACTCGGG CAATAAGACCATCTCAGTGGCCACAGTTGATGGTGGCCGCCGACGCACTCTCTTCAGCCGTAACCTCAGTGAACCCCGGGCCATCGCTGTTGACCCCCTG CGAGGGTTCATGTATTGGTCTGACTGGGGGGACCAGGCCAAGATTGAGAAATCTGGGCTCAACGGTGTGGACCGGCAAACACTGGTGTCAGACAATATTG AATGGCCCAACGGAATCACCCTGGATCTGCTGAGCCAGCGCTTGTACTGGGTAGACTCCAAGCTACACCAACTGTCCAGCATTGACTTCAGTGGAGGCAA CAGAAAGACGCTGATCTCCTCCACTGACTTCCTGAGCCACCCTTTTGGGATAGCTGTGTTTGAGGACAAGGTGTTCTGGACAGACCTGGAGAACGAGGCC ATTTTCAGTGCAAATCGGCTCAATGGCCTGGAAATCTCCATCCTGGCTGAGAACCTCAACAACCCACATGACATTGTCATCTTCCATGAGCTGAAGCAGC CAAGAGCTCCAGATGCCTGTGAGCTGAGTGTCCAGCCTAATGGAGGCTGTGAATACCTGTGCCTTCCTGCTCCTCAGATCTCCAGCCACTCTCCCAAGTA CACATGTGCCTGTCCTGACACAATGTGGCTGGGTCCAGACATGAAGAGGTGCTACCGAGATGCAAATGAAGACAGTAAGATGGGCTCAACAGTCACTGCC GCTGTTATCGGGATCATCGTGCCCATAGTGGTGATAGCCCTCCTGTGCATGAGTGGATACCTGATCTGGAGAAACTGGAAGCGGAAGAACACCAAAAGCA TGAATTTTGACAACCCAGTCTACAGGAAAACAACAGAAGAAGAAGACGAAGATGAGCTCCATATAGGGAGAACTGCTCAGATTGGCCATGTCTATCCTGC ACGAGTGGCATTAAGCCTTGAAGATGATGGACTACCCTGAGGATGGGATCACCCCCTTCGTGCCTCATGGAATTCAGTCCCATGCACTACACTCTGGATG GTGTATGACTGGATGAATGGGTTTCTATATATGGGTCTGTGTGAGTGTATGTGTGTGTGTGATTTTTTTTTTAAATTTATGTTGCGGAAAGGTAACCACA AAGTTATGATGAACTGCAAACATCCAAAGGATGTGAGAGTTTTTCTATGTATAATGTTTTATACACTTTTTAACTGGTTGCACTACCCATGAGGAATTCG TGGAATGGCTACTGCTGACTAACATGATGCACATAACCAAATGGGGGCCAATGGCACAGTACCTTACTCATCATTTAAAAACTATATTTACAGAAGATGT TTGGTTGCTGGGGGGGCTTTTTTAGGTTTTGGGGCATTTGTTTTTTGTAAATAAGATGATTATGCTTTGTGGCTATCCATCAACATAAGTAAAAAAAAAA AAAAAACACTTCAACTCCCTCCCCCATTTAGATTATTTATTAACATATTTTAAAAATCAGATGAGTTCTATAAATAATTTAGAGAAGTGAGAGTATTTAT TTTTGGCATGTTTGGCCCACCACACAGACTCTGTGTGTGTATGTGTGTGTTTATATGTGTATGTGTGTGACAGAAAAATCTGTAGAGAAGAGGCACATCT ATGGCTACTGTTCAAATACATAAAGATAAATTTATTTTCACACAGTCCACAAGGGGTATATCTTGTAGTTTTCAGAAAAGCCTTTGGAAATCTGGATCAG AAAATAGATACCATGGTTTGTGCAATTATGTAGTAAAAAAGGCAAATCTTTTCACCTCTGGCTATTCCTGAGACCCCAGGAAGTCAGGAAAAGCCTTTCA GCTCACCCATGGCTGCTGTGACTCCTACCAGGGCTTTCTTGGCTTTGGCGAAGGTCAGTGTACAGACATTCCATGGTACCAGAGTGCTCAGAAACTCAAG ATAGGATATGCCTCACCCTCAGCTACTCCTTGTTTTAAAGTTCAGCTCTTTGAGTAACTTCTTCAATTTCTTTCAGGACACTTGGGTTGAATTCAGTAAG TTTCCTCTGAAGCACCCTGAAGGGTGCCATCCTTACAGAGCTAAGTGGAGACGTTTCCAGATCAGCCCAAGTTTACTATAGAGACTGGCCCAGGCACTGA ATGTCTAGGACATGCTGTGGATGAAGATAAAGATGGTGGAATAGGTTTTATCACATCTCTTATTTCTCTTTTCCCCTTACTCTCTACCATTTCCTTTATG TGGGGAAACATTTTAAGGTAATAAATAGGTTACTTACCATCATATGTTCATATAGATGAAACTAATTTTTGGCTTAAGTCAGAACAACTGGCCAAAATTG AAGTCATATTTGAGGGGGGAAATGGCATACGCAATATTATATTATATTGGATATTTATGTTCACACAGGAATTTGGTTTACTGCTTTGTAAATAAAAGGA AAAACTCCGGGTATATGT

refseq_LRP8.F3 (forward primer)
refseq_LRP8.R3 (reverse primer)
Single exon skipping

Frame 0

AGGGRPGPGPRAQPEPAPPPSVTEPA*NAAEEP GRAAAAAAAAAGAAATPAPRQGLGGLRRGGGGAG SAGRGGRSPGPAMGLPEPGPLRLLALLLLLLLL LLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQC RNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCAD SDFTCDNGHCIHERWKCDGEEECPDGSDESEAT CTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDC EGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKH CNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHI CTDLKIGFECTCPAGFQLLDQKTCGDIDECKDP DACSQICVNYKGYFKCECYPGYEMDLLTKNCKAA AGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLK NVVALDVEVATNRIYWCDLSYRKIYSAYMDKAS DPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSG NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL RGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGN RKTLISSTDFLSHPFGIAVFEDKVFWTDLENEA IFSANRLNGLEISILAENLNNPHDIVIFHELKQ PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKY TCACPDTMWLGPDMKRCYRDANEDSKMGSTVTA AVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKS MNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPA RVALSLEDDGLP*GWDHPLRASWNSVPCTTLWM VYDWMNGFLYMGLCECMCVCDFFFKFMLRKGNH KVMMNCKHPKDVRVFLCIMFYTLFNWLHYP*GIR GMATAD*HDAHNQMGANGTVPYSSFKNYIYRRC LVAGGAFLGFGAFVFCK*DDYALWLSINISKKK KKTLQLPPPFRLFINIF*KSDEFYK*FREVRVFI FGMFGPPHRLCVCMCVFICVCV*QKNL*RRGTS MATVQIHKDKFIFTQSTRGISCSFQKSLWKSGS ENRYHGLCNYVVKKANLFTSGYS*DPRKSGKAFQ LTHGCCDSYQGFLGFGEGQCTDIPWYQSAQKLK IGYASPSATPCFKVQLFE*LLQFLSGHLG*IQ* VSSEAP*RVPSLQS*VETFPDQPKFTIETGPGTE CLGHAVDEDKDGGIGFITSLISLFPLLSTISFM WGNILR**IGYLPSYVHIDETNFWLKSEQLAKI EVIFEGGNGIRNIILYWIFMFTQEFGLLLCK*KE KLRVY

Frame 1

LAAAAQGRGRAPSLSPPRRRASPNLLEMQPRSR GGRQRRRRRRRGQRQPRRRGKDSEG*DAAAAAR GARGAAAGAPGPPWASPSRALSGFWRCCCCCCCC CCCSSSILRRQRLIRCSAAKGRPRIAKRTNSSA GTSAASPLCGDATRTMTA*TTATRTTAPRRPVQ TVTSPVTTATASTNGGSVTARRSVLMAPMSPRPL APSRCVLQRS*AVDPPATSVYLPRGAATGRRTA RVERMRPAVLPHWAPAVGTSSSVGMGHVSLQSS TATRSRTVQMGVMKLAAYRG*TSVCTTMAAAHTS ALTSRLALNARAQQASSSWTRRPVATLMSARTQ MPAARSVSITRAILSVSATLATRWTY*PRTARL LLARAHP*SSPTGTRCGGSTW*SGTIHASSPCSR MSWH*MWKLPPIASTGVTSPTVRSIAPTWTRPV TRKSRRSSLTSSCTLQRAWQWTGSTSTSTGLTR AIRPSQWPQLMVAADALSSAVTSVNPGPSLLTPC EGSCIGLTGGTRPRLRNLGSTVWTGKHWCQTIL NGPTESPWIC*ASACTG*TPSYTNCPALTSVEA TERR*SPPLTS*ATLLG*LCLRTRCSGQTWRTRP FSVQIGSMAWKSPSWLRTSTTHMTLSSSMS*SS QELQMPVS*VSSLMEAVNTCAFLLLRSPATLPS THVPVLTQCGWVQT*RGATEMQMKTVRWAQQSLP LLSGSSCP*W**PSCA*VDT*SGETGSGRTPKA *ILTTQSTGKQQKKKTKMSSI*GELLRLAMSIL HEWH*ALKMMDYPEDGITPFVPHGIQSHALHSGW CMTG*MGFYIWVCVSVCVCVIFFLNLCCGKVTT KL**TANIQRM*EFFYV*CFIHFLTGCTTHEEF VEWLLLTNMMHITKWGPMAQYLTHHLKTIFTEDV WLLGGLF*VLGHLFFVNKMIMLCGYPST*VKKK KKHFNSLPHLDYLLTYFKNQMSSINNLEK*EYL FLACLAHHTDSVCVCVCLYVYVCDRKICREEAHL WLLFKYIKINLFSHSPQGVYLVVFRKAFGNLDQ KIDTMVCAIM**KRQIFSPLAIPETPGSQEKPF SSPMAAVTPTRAFLALAKVSVQTFHGTRVLRNSR *DMPHPQLLLVLKFSSLSNFFNFFQDTWVEFSK FPLKHPEGCHPYRAKWRRFQISPSLL*RLAQAL NV*DMLWMKIKMVE*VLSHLLFLFSPYSLPFPLC GETF*GNK*VTYHHMFI*MKLIFGLSQNNWPKL KSYLRGEMAYAILYYIGYLCSHRNLVYCFVNKR KNSGYM

Frame 2

WRRPPRAGAARPA*ARPAAERHRTCLKCSRGAG AGGSGGGGGGGGSGNPGAAARTRRAETRRRRRG ERGARRPEPRARHGPPRAGPSPASGAAAAAAAA AAAAAPASCGGSG*SAARRPRAGQGLRKGPIPVP ERALHPLCVEMRRGR*LLRPQRRGRLPQEDLCR Q*LHL*QRPLHPRTVEV*RRGGVS*WLR*VRGH LHQAGVSCREAELWTHQPQVCTCLVALRRGEGLR GWSG*GRLCYLTGHLPWGRVPVWGWDMCPCNQA LQPGAGLSRWE**SWLPTGAERVSAQQWRLLTH LH*PQDWL*MHVPSRLPAPGPEDLWRH**VQGPR CLQPDLCQLQGLF*V*VLPWLRDGPTDQELQGC CWQEPIPNLHQPARGAEDRPGEAELFTPHPHAQ ECRGTRCGSCHQSHLLV*PLLP*DL*RLHGQGQ* PERAGGPH*RAVALSRGPGSGLGPQAHLLD*LG Q*DHLSGHS*WWPPTHSLQP*PQ*TPGHRC*PP ARVHVLV*LGGPGQD*EIWAQRCGPANTGVRQY* MAQRNHPGSAEPALVLGRLQATPTVQH*LQWRQ QKDADLLH*LPEPPFWDSCV*GQGVLDRPGERG HFQCKSAQWPGNLHPG*EPQQPT*HCHLP*AEAA KSSRCL*AECPA*WRL*IPVPSCSSDLQPLSQV HMCLS*HNVAGSRHEEVLPRCK*RQ*DGLNSHC RCYRDHRAHSGDSPPVHEWIPDLEKLEAEEHQKH EF*QPSLQENNRRRRRR*APYRENCSDWPCLSC TSGIKP*R*WTTLRMGSPPSCLMEFSPMHYTLD GV*LDEWVSIYGSV*VYVCV*FFF*IYVAER*PQ SYDELQTSKGCESFSMYNVLYTF*LVALPMRNS WNGYC*LT*CT*PNGGQWHSTLLII*KLYLQKM FGCWGGFFRFWGICFL*IR*LCFVAIHQHK*KKK KNTSTPSPI*IIY*HILKIR*VL*II*RSESIY FWHVWPTTQTLCVYVCVYMCMCVTEKSVEKRHI YGYCSNT*R*IYFHTVHKGYIL*FSEKPLEIWIR K*IPWFVQLCSKKGKSFHLWLFLRPQEVRKSLS AHPWLL*LLPGLSWLWRRSVYRHSMVPECSETQ DRICLTLSYSLF*SSAL*VTSSISFRTLGLNSVS FL*STLKGAILTELSGDVSRSAQVYYRDWPRH* MSRTCCG*R*RWWNRFYHISYFSFPLTLYHFLY VGKHFKVINRLLTIICSYR*N*FLA*VRTTGQN* SHI*GGKWHTQYYIILDIYVHTGIWFTAL*IKG KTPGIC

Sequence NM_001018054

GCTGGCGGCGGCCGCCCAGGGCCGGGGCCGCGCGCCCAGCCTGAGCCCGCCCCGCCGCCGAGCGTCACCGAACCTGCTTGAAATGCAGCCGAGGAGCCGG GGCGGGCGGCAGCGGCGGCGGCGGCGGCGGCGGGGGCAGCGGCAACCCCGGCGCCGCGGCAAGGACTCGGAGGGCTGAGACGCGGCGGCGGCGGCGCGGG GAGCGCGGGGCGCGGCGGCCGGAGCCCCGGGCCCGCCATGGGCCTCCCCGAGCCGGGCCCTCTCCGGCTTCTGGCGCTGCTGCTGCTGCTGCTGCTGCTG CTGCTGCTGCAGCTCCAGCATCTTGCGGCGGCAGCGGCTGATCCGCTGCTCGGCGGCCAAGGGCCGGCCAAGGATTGCGAAAAGGACCAATTCCAGTGCC GGAACGAGCGCTGCATCCCCTCTGTGTGGAGATGCGACGAGGACGATGACTGCTTAGACCACAGCGACGAGGACGACTGCCCCAAGAAGACCTGTGCAGA CAGTGACTTCACCTGTGACAACGGCCACTGCATCCACGAACGGTGGAAGTGTGACGGCGAGGAGGAGTGTCCTGATGGCTCCGATGAGTCCGAGGCCACT TGCACCAAGCAGGTGTGTCCTGCAGAGAAGCTGAGCTGTGGACCCACCAGCCACAAGTGTGTACCTGCCTCGTGGCGCTGCGACGGGGAGAAGGACTGCG AGGGTGGAGCGGATGAGGCCGGCTGTGCTACCTTGTGCGCCCCGCACGAGTTCCAGTGCGGCAACCGCTCGTGCCTGGCCGCCGTGTTCGTGTGCGACGG CGACGACGACTGTGGTGACGGCAGCGATGAGCGCGGCTGTGCAGACCCGGCCTGCGGGCCCCGCGAGTTCCGCTGCGGCGGCGATGGCGGCGGCGCCTGC ATCCCGGAGCGCTGGGTCTGCGACCGCCAGTTTGACTGCGAGGACCGCTCGGACGAGGCAGCCGAGCTCTGCGGCCGTCCGGGCCCCGGGGCCACGTCCG CGCCCGCCGCCTGCGCCACCGCCTCCCAGTTCGCCTGCCGCAGCGGCGAGTGCGTGCACCTGGGCTGGCGCTGCGACGGCGACCGCGACTGCAAAGACAA ATCGGACGAGGCCGACTGCCCACTGGGCACCTGCCGTGGGGACGAGTTCCAGTGTGGGGATGGGACATGTGTCCTTGCAATCAAGCACTGCAACCAGGAG CAGGACTGTCCAGATGGGAGTGATGAAGCTGGCTGCCTACAGGGGCTGAACGAGTGTCTGCACAACAATGGCGGCTGCTCACACATCTGCACTGACCTCA AGATTGGCTTTGAATGCACGTGCCCAGCAGGCTTCCAGCTCCTGGACCAGAAGACCTGTGGCGACATTGATGAGTGCAAGGACCCAGATGCCTGCAGCCA GATCTGTGTCAATTACAAGGGCTATTTTAAGTGTGAGTGCTACCCTGGCTACGAGATGGACCTACTGACCAAGAACTGCAAGGCTGCTGCTGGCAAGAGC CCATCCCTAATCTTCACCAACCGGCACGAGGTGCGGAGGATCGACCTGGTGAAGCGGAACTATTCACGCCTCATCCCCATGCTCAAGAATGTCGTGGCAC TAGATGTGGAAGTTGCCACCAATCGCATCTACTGGTGTGACCTCTCCTACCGTAAGATCTATAGCGCCTACATGGACAAGGCCAGTGACCCGAAAGAGCA GGAGGTCCTCATTGACGAGCAGTTGCACTCTCCAGAGGGCCTGGCAGTGGACTGGGTCCACAAGCACATCTACTGGACTGACTCGGGCAATAAGACCATC TCAGTGGCCACAGTTGATGGTGGCCGCCGACGCACTCTCTTCAGCCGTAACCTCAGTGAACCCCGGGCCATCGCTGTTGACCCCCTGCGAGGGTTCATGT ATTGGTCTGACTGGGGGGACCAGGCCAAGATTGAGAAATCTGGGCTCAACGGTGTGGACCGGCAAACACTGGTGTCAGACAATATTGAATGGCCCAACGG AATCACCCTGGATCTGCTGAGCCAGCGCTTGTACTGGGTAGACTCCAAGCTACACCAACTGTCCAGCATTGACTTCAGTGGAGGCAACAGAAAGACGCTG ATCTCCTCCACTGACTTCCTGAGCCACCCTTTTGGGATAGCTGTGTTTGAGGACAAGGTGTTCTGGACAGACCTGGAGAACGAGGCCATTTTCAGTGCAA ATCGGCTCAATGGCCTGGAAATCTCCATCCTGGCTGAGAACCTCAACAACCCACATGACATTGTCATCTTCCATGAGCTGAAGCAGCCAAGAGCTCCAGA TGCCTGTGAGCTGAGTGTCCAGCCTAATGGAGGCTGTGAATACCTGTGCCTTCCTGCTCCTCAGATCTCCAGCCACTCTCCCAAGTACACATGTGCCTGT CCTGACACAATGTGGCTGGGTCCAGACATGAAGAGGTGCTACCGAGCACCTCAATCTACCTCAACTACGACGTTAGCTTCTACCATGACGAGGACAGTAC CTGCCACCACAAGAGCCCCCGGGACCACCGTCCACAGATCCACCTACCAGAACCACAGCACAGAGACACCAAGCCTGACAGCTGCAGTCCCAAGCTCAGT TAGTGTCCCCAGGGCTCCCAGCATCAGCCCGTCTACCCTAAGCCCTGCAACCAGCAACCACTCCCAGCACTATGCAAATGAAGACAGTAAGATGGGCTCA ACAGTCACTGCCGCTGTTATCGGGATCATCGTGCCCATAGTGGTGATAGCCCTCCTGTGCATGAGTGGATACCTGATCTGGAGAAACTGGAAGCGGAAGA ACACCAAAAGCATGAATTTTGACAACCCAGTCTACAGGAAAACAACAGAAGAAGAAGACGAAGATGAGCTCCATATAGGGAGAACTGCTCAGATTGGCCA TGTCTATCCTGCACGAGTGGCATTAAGCCTTGAAGATGATGGACTACCCTGAGGATGGGATCACCCCCTTCGTGCCTCATGGAATTCAGTCCCATGCACT ACACTCTGGATGGTGTATGACTGGATGAATGGGTTTCTATATATGGGTCTGTGTGAGTGTATGTGTGTGTGTGATTTTTTTTTTAAATTTATGTTGCGGA AAGGTAACCACAAAGTTATGATGAACTGCAAACATCCAAAGGATGTGAGAGTTTTTCTATGTATAATGTTTTATACACTTTTTAACTGGTTGCACTACCC ATGAGGAATTCGTGGAATGGCTACTGCTGACTAACATGATGCACATAACCAAATGGGGGCCAATGGCACAGTACCTTACTCATCATTTAAAAACTATATT TACAGAAGATGTTTGGTTGCTGGGGGGGCTTTTTTAGGTTTTGGGGCATTTGTTTTTTGTAAATAAGATGATTATGCTTTGTGGCTATCCATCAACATAA GTAAAAAAAAAAAAAAAACACTTCAACTCCCTCCCCCATTTAGATTATTTATTAACATATTTTAAAAATCAGATGAGTTCTATAAATAATTTAGAGAAGT GAGAGTATTTATTTTTGGCATGTTTGGCCCACCACACAGACTCTGTGTGTGTATGTGTGTGTTTATATGTGTATGTGTGTGACAGAAAAATCTGTAGAGA AGAGGCACATCTATGGCTACTGTTCAAATACATAAAGATAAATTTATTTTCACACAGTCCACAAGGGGTATATCTTGTAGTTTTCAGAAAAGCCTTTGGA AATCTGGATCAGAAAATAGATACCATGGTTTGTGCAATTATGTAGTAAAAAAGGCAAATCTTTTCACCTCTGGCTATTCCTGAGACCCCAGGAAGTCAGG AAAAGCCTTTCAGCTCACCCATGGCTGCTGTGACTCCTACCAGGGCTTTCTTGGCTTTGGCGAAGGTCAGTGTACAGACATTCCATGGTACCAGAGTGCT CAGAAACTCAAGATAGGATATGCCTCACCCTCAGCTACTCCTTGTTTTAAAGTTCAGCTCTTTGAGTAACTTCTTCAATTTCTTTCAGGACACTTGGGTT GAATTCAGTAAGTTTCCTCTGAAGCACCCTGAAGGGTGCCATCCTTACAGAGCTAAGTGGAGACGTTTCCAGATCAGCCCAAGTTTACTATAGAGACTGG CCCAGGCACTGAATGTCTAGGACATGCTGTGGATGAAGATAAAGATGGTGGAATAGGTTTTATCACATCTCTTATTTCTCTTTTCCCCTTACTCTCTACC ATTTCCTTTATGTGGGGAAACATTTTAAGGTAATAAATAGGTTACTTACCATCATATGTTCATATAGATGAAACTAATTTTTGGCTTAAGTCAGAACAAC TGGCCAAAATTGAAGTCATATTTGAGGGGGGAAATGGCATACGCAATATTATATTATATTGGATATTTATGTTCACACAGGAATTTGGTTTACTGCTTTG TAAATAAAAGGAAAAACTCCGGGTATATGT

refseq_LRP8.F3 (forward primer)
refseq_LRP8.R3 (reverse primer)
Single exon skipping

Frame 0

AGGGRPGPGPRAQPEPAPPPSVTEPA*NAAEEP GRAAAAAAAAAGAAATPAPRQGLGGLRRGGGGAG SAGRGGRSPGPAMGLPEPGPLRLLALLLLLLLL LLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQC RNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCAD SDFTCDNGHCIHERWKCDGEEECPDGSDESEAT CTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDC EGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDG DDDCGDGSDERGCADPACGPREFRCGGDGGGAC IPERWVCDRQFDCEDRSDEAAELCGRPGPGATS APAACATASQFACRSGECVHLGWRCDGDRDCKDK SDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQE QDCPDGSDEAGCLQGLNECLHNNGGCSHICTDL KIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQ ICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKS PSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVA LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQ EVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTI SVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFM YWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNG ITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA NRLNGLEISILAENLNNPHDIVIFHELKQPRAPD ACELSVQPNGGCEYLCLPAPQISSHSPKYTCAC PDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTV PATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSV SVPRAPSISPSTLSPATSNHSQHYANEDSKMGS TVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRK NTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGH VYPARVALSLEDDGLP*GWDHPLRASWNSVPCT TLWMVYDWMNGFLYMGLCECMCVCDFFFKFMLR KGNHKVMMNCKHPKDVRVFLCIMFYTLFNWLHYP *GIRGMATAD*HDAHNQMGANGTVPYSSFKNYI YRRCLVAGGAFLGFGAFVFCK*DDYALWLSINI SKKKKKTLQLPPPFRLFINIF*KSDEFYK*FREV RVFIFGMFGPPHRLCVCMCVFICVCV*QKNL*R RGTSMATVQIHKDKFIFTQSTRGISCSFQKSLW KSGSENRYHGLCNYVVKKANLFTSGYS*DPRKSG KAFQLTHGCCDSYQGFLGFGEGQCTDIPWYQSA QKLKIGYASPSATPCFKVQLFE*LLQFLSGHLG *IQ*VSSEAP*RVPSLQS*VETFPDQPKFTIETG PGTECLGHAVDEDKDGGIGFITSLISLFPLLST ISFMWGNILR**IGYLPSYVHIDETNFWLKSEQ LAKIEVIFEGGNGIRNIILYWIFMFTQEFGLLLC K*KEKLRVY

Frame 1

LAAAAQGRGRAPSLSPPRRRASPNLLEMQPRSR GGRQRRRRRRRGQRQPRRRGKDSEG*DAAAAAR GARGAAAGAPGPPWASPSRALSGFWRCCCCCCCC CCCSSSILRRQRLIRCSAAKGRPRIAKRTNSSA GTSAASPLCGDATRTMTA*TTATRTTAPRRPVQ TVTSPVTTATASTNGGSVTARRSVLMAPMSPRPL APSRCVLQRS*AVDPPATSVYLPRGAATGRRTA RVERMRPAVLPCAPRTSSSAATARAWPPCSCAT ATTTVVTAAMSAAVQTRPAGPASSAAAAMAAAPA SRSAGSATASLTARTARTRQPSSAAVRAPGPRP RPPPAPPPPSSPAAAASACTWAGAATATATAKT NRTRPTAHWAPAVGTSSSVGMGHVSLQSSTATRS RTVQMGVMKLAAYRG*TSVCTTMAAAHTSALTS RLALNARAQQASSSWTRRPVATLMSARTQMPAA RSVSITRAILSVSATLATRWTY*PRTARLLLARA HP*SSPTGTRCGGSTW*SGTIHASSPCSRMSWH *MWKLPPIASTGVTSPTVRSIAPTWTRPVTRKS RRSSLTSSCTLQRAWQWTGSTSTSTGLTRAIRPS QWPQLMVAADALSSAVTSVNPGPSLLTPCEGSC IGLTGGTRPRLRNLGSTVWTGKHWCQTILNGPT ESPWIC*ASACTG*TPSYTNCPALTSVEATERR* SPPLTS*ATLLG*LCLRTRCSGQTWRTRPFSVQ IGSMAWKSPSWLRTSTTHMTLSSSMS*SSQELQ MPVS*VSSLMEAVNTCAFLLLRSPATLPSTHVPV LTQCGWVQT*RGATEHLNLPQLRR*LLP*RGQY LPPQEPPGPPSTDPPTRTTAQRHQA*QLQSQAQ LVSPGLPASARLP*ALQPATTPSTMQMKTVRWAQ QSLPLLSGSSCP*W**PSCA*VDT*SGETGSGR TPKA*ILTTQSTGKQQKKKTKMSSI*GELLRLA MSILHEWH*ALKMMDYPEDGITPFVPHGIQSHAL HSGWCMTG*MGFYIWVCVSVCVCVIFFLNLCCG KVTTKL**TANIQRM*EFFYV*CFIHFLTGCTT HEEFVEWLLLTNMMHITKWGPMAQYLTHHLKTIF TEDVWLLGGLF*VLGHLFFVNKMIMLCGYPST* VKKKKKHFNSLPHLDYLLTYFKNQMSSINNLEK *EYLFLACLAHHTDSVCVCVCLYVYVCDRKICRE EAHLWLLFKYIKINLFSHSPQGVYLVVFRKAFG NLDQKIDTMVCAIM**KRQIFSPLAIPETPGSQ EKPFSSPMAAVTPTRAFLALAKVSVQTFHGTRVL RNSR*DMPHPQLLLVLKFSSLSNFFNFFQDTWV EFSKFPLKHPEGCHPYRAKWRRFQISPSLL*RL AQALNV*DMLWMKIKMVE*VLSHLLFLFSPYSLP FPLCGETF*GNK*VTYHHMFI*MKLIFGLSQNN WPKLKSYLRGEMAYAILYYIGYLCSHRNLVYCF VNKRKNSGYM

Frame 2

WRRPPRAGAARPA*ARPAAERHRTCLKCSRGAG AGGSGGGGGGGGSGNPGAAARTRRAETRRRRRG ERGARRPEPRARHGPPRAGPSPASGAAAAAAAA AAAAAPASCGGSG*SAARRPRAGQGLRKGPIPVP ERALHPLCVEMRRGR*LLRPQRRGRLPQEDLCR Q*LHL*QRPLHPRTVEV*RRGGVS*WLR*VRGH LHQAGVSCREAELWTHQPQVCTCLVALRRGEGLR GWSG*GRLCYLVRPARVPVRQPLVPGRRVRVRR RRRLW*RQR*ARLCRPGLRAPRVPLRRRWRRRL HPGALGLRPPV*LRGPLGRGSRALRPSGPRGHVR ARRLRHRLPVRLPQRRVRAPGLALRRRPRLQRQ IGRGRLPTGHLPWGRVPVWGWDMCPCNQALQPG AGLSRWE**SWLPTGAERVSAQQWRLLTHLH*PQ DWL*MHVPSRLPAPGPEDLWRH**VQGPRCLQP DLCQLQGLF*V*VLPWLRDGPTDQELQGCCWQE PIPNLHQPARGAEDRPGEAELFTPHPHAQECRGT RCGSCHQSHLLV*PLLP*DL*RLHGQGQ*PERA GGPH*RAVALSRGPGSGLGPQAHLLD*LGQ*DH LSGHS*WWPPTHSLQP*PQ*TPGHRC*PPARVHV LV*LGGPGQD*EIWAQRCGPANTGVRQY*MAQR NHPGSAEPALVLGRLQATPTVQH*LQWRQQKDA DLLH*LPEPPFWDSCV*GQGVLDRPGERGHFQCK SAQWPGNLHPG*EPQQPT*HCHLP*AEAAKSSR CL*AECPA*WRL*IPVPSCSSDLQPLSQVHMCL S*HNVAGSRHEEVLPSTSIYLNYDVSFYHDEDST CHHKSPRDHRPQIHLPEPQHRDTKPDSCSPKLS *CPQGSQHQPVYPKPCNQQPLPALCK*RQ*DGL NSHCRCYRDHRAHSGDSPPVHEWIPDLEKLEAEE HQKHEF*QPSLQENNRRRRRR*APYRENCSDWP CLSCTSGIKP*R*WTTLRMGSPPSCLMEFSPMH YTLDGV*LDEWVSIYGSV*VYVCV*FFF*IYVAE R*PQSYDELQTSKGCESFSMYNVLYTF*LVALP MRNSWNGYC*LT*CT*PNGGQWHSTLLII*KLY LQKMFGCWGGFFRFWGICFL*IR*LCFVAIHQHK *KKKKNTSTPSPI*IIY*HILKIR*VL*II*RS ESIYFWHVWPTTQTLCVYVCVYMCMCVTEKSVE KRHIYGYCSNT*R*IYFHTVHKGYIL*FSEKPLE IWIRK*IPWFVQLCSKKGKSFHLWLFLRPQEVR KSLSAHPWLL*LLPGLSWLWRRSVYRHSMVPEC SETQDRICLTLSYSLF*SSAL*VTSSISFRTLGL NSVSFL*STLKGAILTELSGDVSRSAQVYYRDW PRH*MSRTCCG*R*RWWNRFYHISYFSFPLTLY HFLYVGKHFKVINRLLTIICSYR*N*FLA*VRTT GQN*SHI*GGKWHTQYYIILDIYVHTGIWFTAL *IKGKTPGIC

Sequence NM_004631

GCTGGCGGCGGCCGCCCAGGGCCGGGGCCGCGCGCCCAGCCTGAGCCCGCCCCGCCGCCGAGCGTCACCGAACCTGCTTGAAATGCAGCCGAGGAGCCGG GGCGGGCGGCAGCGGCGGCGGCGGCGGCGGCGGGGGCAGCGGCAACCCCGGCGCCGCGGCAAGGACTCGGAGGGCTGAGACGCGGCGGCGGCGGCGCGGG GAGCGCGGGGCGCGGCGGCCGGAGCCCCGGGCCCGCCATGGGCCTCCCCGAGCCGGGCCCTCTCCGGCTTCTGGCGCTGCTGCTGCTGCTGCTGCTGCTG CTGCTGCTGCAGCTCCAGCATCTTGCGGCGGCAGCGGCTGATCCGCTGCTCGGCGGCCAAGGGCCGGCCAAGGATTGCGAAAAGGACCAATTCCAGTGCC GGAACGAGCGCTGCATCCCCTCTGTGTGGAGATGCGACGAGGACGATGACTGCTTAGACCACAGCGACGAGGACGACTGCCCCAAGAAGACCTGTGCAGA CAGTGACTTCACCTGTGACAACGGCCACTGCATCCACGAACGGTGGAAGTGTGACGGCGAGGAGGAGTGTCCTGATGGCTCCGATGAGTCCGAGGCCACT TGCACCAAGCAGGTGTGTCCTGCAGAGAAGCTGAGCTGTGGACCCACCAGCCACAAGTGTGTACCTGCCTCGTGGCGCTGCGACGGGGAGAAGGACTGCG AGGGTGGAGCGGATGAGGCCGGCTGTGCTACCTTGTGCGCCCCGCACGAGTTCCAGTGCGGCAACCGCTCGTGCCTGGCCGCCGTGTTCGTGTGCGACGG CGACGACGACTGTGGTGACGGCAGCGATGAGCGCGGCTGTGCAGACCCGGCCTGCGGGCCCCGCGAGTTCCGCTGCGGCGGCGATGGCGGCGGCGCCTGC ATCCCGGAGCGCTGGGTCTGCGACCGCCAGTTTGACTGCGAGGACCGCTCGGACGAGGCAGCCGAGCTCTGCGGCCGTCCGGGCCCCGGGGCCACGTCCG CGCCCGCCGCCTGCGCCACCGCCTCCCAGTTCGCCTGCCGCAGCGGCGAGTGCGTGCACCTGGGCTGGCGCTGCGACGGCGACCGCGACTGCAAAGACAA ATCGGACGAGGCCGACTGCCCACTGGGCACCTGCCGTGGGGACGAGTTCCAGTGTGGGGATGGGACATGTGTCCTTGCAATCAAGCACTGCAACCAGGAG CAGGACTGTCCAGATGGGAGTGATGAAGCTGGCTGCCTACAGGGGCTGAACGAGTGTCTGCACAACAATGGCGGCTGCTCACACATCTGCACTGACCTCA AGATTGGCTTTGAATGCACGTGCCCAGCAGGCTTCCAGCTCCTGGACCAGAAGACCTGTGGCGACATTGATGAGTGCAAGGACCCAGATGCCTGCAGCCA GATCTGTGTCAATTACAAGGGCTATTTTAAGTGTGAGTGCTACCCTGGCTACGAGATGGACCTACTGACCAAGAACTGCAAGGCTGCTGCTGGCAAGAGC CCATCCCTAATCTTCACCAACCGGCACGAGGTGCGGAGGATCGACCTGGTGAAGCGGAACTATTCACGCCTCATCCCCATGCTCAAGAATGTCGTGGCAC TAGATGTGGAAGTTGCCACCAATCGCATCTACTGGTGTGACCTCTCCTACCGTAAGATCTATAGCGCCTACATGGACAAGGCCAGTGACCCGAAAGAGCA GGAGGTCCTCATTGACGAGCAGTTGCACTCTCCAGAGGGCCTGGCAGTGGACTGGGTCCACAAGCACATCTACTGGACTGACTCGGGCAATAAGACCATC TCAGTGGCCACAGTTGATGGTGGCCGCCGACGCACTCTCTTCAGCCGTAACCTCAGTGAACCCCGGGCCATCGCTGTTGACCCCCTGCGAGGGTTCATGT ATTGGTCTGACTGGGGGGACCAGGCCAAGATTGAGAAATCTGGGCTCAACGGTGTGGACCGGCAAACACTGGTGTCAGACAATATTGAATGGCCCAACGG AATCACCCTGGATCTGCTGAGCCAGCGCTTGTACTGGGTAGACTCCAAGCTACACCAACTGTCCAGCATTGACTTCAGTGGAGGCAACAGAAAGACGCTG ATCTCCTCCACTGACTTCCTGAGCCACCCTTTTGGGATAGCTGTGTTTGAGGACAAGGTGTTCTGGACAGACCTGGAGAACGAGGCCATTTTCAGTGCAA ATCGGCTCAATGGCCTGGAAATCTCCATCCTGGCTGAGAACCTCAACAACCCACATGACATTGTCATCTTCCATGAGCTGAAGCAGCCAAGAGCTCCAGA TGCCTGTGAGCTGAGTGTCCAGCCTAATGGAGGCTGTGAATACCTGTGCCTTCCTGCTCCTCAGATCTCCAGCCACTCTCCCAAGTACACATGTGCCTGT CCTGACACAATGTGGCTGGGTCCAGACATGAAGAGGTGCTACCGAGCACCTCAATCTACCTCAACTACGACGTTAGCTTCTACCATGACGAGGACAGTAC CTGCCACCACAAGAGCCCCCGGGACCACCGTCCACAGATCCACCTACCAGAACCACAGCACAGAGACACCAAGCCTGACAGCTGCAGTCCCAAGCTCAGT TAGTGTCCCCAGGGCTCCCAGCATCAGCCCGTCTACCCTAAGCCCTGCAACCAGCAACCACTCCCAGCACTATGCAAATGAAGACAGTAAGATGGGCTCA ACAGTCACTGCCGCTGTTATCGGGATCATCGTGCCCATAGTGGTGATAGCCCTCCTGTGCATGAGTGGATACCTGATCTGGAGAAACTGGAAGCGGAAGA ACACCAAAAGCATGAATTTTGACAACCCAGTCTACAGGAAAACAACAGAAGAAGAAGACGAAGATGAGCTCCATATAGGGAGAACTGCTCAGATTGGCCA TGTCTATCCTGCAGCAATCAGCAGCTTTGATCGCCCACTGTGGGCAGAGCCCTGTCTTGGGGAGACCAGAGAACCGGAAGACCCAGCCCCTGCCCTCAAG GAGCTTTTTGTCTTGCCGGGGGAACCAAGGTCACAGCTGCACCAACTCCCGAAGAACCCTCTTTCCGAGCTGCCTGTCGTCAAATCCAAGCGAGTGGCAT TAAGCCTTGAAGATGATGGACTACCCTGAGGATGGGATCACCCCCTTCGTGCCTCATGGAATTCAGTCCCATGCACTACACTCTGGATGGTGTATGACTG GATGAATGGGTTTCTATATATGGGTCTGTGTGAGTGTATGTGTGTGTGTGATTTTTTTTTTAAATTTATGTTGCGGAAAGGTAACCACAAAGTTATGATG AACTGCAAACATCCAAAGGATGTGAGAGTTTTTCTATGTATAATGTTTTATACACTTTTTAACTGGTTGCACTACCCATGAGGAATTCGTGGAATGGCTA CTGCTGACTAACATGATGCACATAACCAAATGGGGGCCAATGGCACAGTACCTTACTCATCATTTAAAAACTATATTTACAGAAGATGTTTGGTTGCTGG GGGGGCTTTTTTAGGTTTTGGGGCATTTGTTTTTTGTAAATAAGATGATTATGCTTTGTGGCTATCCATCAACATAAGTAAAAAAAAAAAAAAAACACTT CAACTCCCTCCCCCATTTAGATTATTTATTAACATATTTTAAAAATCAGATGAGTTCTATAAATAATTTAGAGAAGTGAGAGTATTTATTTTTGGCATGT TTGGCCCACCACACAGACTCTGTGTGTGTATGTGTGTGTTTATATGTGTATGTGTGTGACAGAAAAATCTGTAGAGAAGAGGCACATCTATGGCTACTGT TCAAATACATAAAGATAAATTTATTTTCACACAGTCCACAAGGGGTATATCTTGTAGTTTTCAGAAAAGCCTTTGGAAATCTGGATCAGAAAATAGATAC CATGGTTTGTGCAATTATGTAGTAAAAAAGGCAAATCTTTTCACCTCTGGCTATTCCTGAGACCCCAGGAAGTCAGGAAAAGCCTTTCAGCTCACCCATG GCTGCTGTGACTCCTACCAGGGCTTTCTTGGCTTTGGCGAAGGTCAGTGTACAGACATTCCATGGTACCAGAGTGCTCAGAAACTCAAGATAGGATATGC CTCACCCTCAGCTACTCCTTGTTTTAAAGTTCAGCTCTTTGAGTAACTTCTTCAATTTCTTTCAGGACACTTGGGTTGAATTCAGTAAGTTTCCTCTGAA GCACCCTGAAGGGTGCCATCCTTACAGAGCTAAGTGGAGACGTTTCCAGATCAGCCCAAGTTTACTATAGAGACTGGCCCAGGCACTGAATGTCTAGGAC ATGCTGTGGATGAAGATAAAGATGGTGGAATAGGTTTTATCACATCTCTTATTTCTCTTTTCCCCTTACTCTCTACCATTTCCTTTATGTGGGGAAACAT TTTAAGGTAATAAATAGGTTACTTACCATCATATGTTCATATAGATGAAACTAATTTTTGGCTTAAGTCAGAACAACTGGCCAAAATTGAAGTCATATTT GAGGGGGGAAATGGCATACGCAATATTATATTATATTGGATATTTATGTTCACACAGGAATTTGGTTTACTGCTTTGTAAATAAAAGGAAAAACTCCGGG TATATGT

refseq_LRP8.F3 (forward primer)
refseq_LRP8.R3 (reverse primer)
Single exon skipping

Frame 0

AGGGRPGPGPRAQPEPAPPPSVTEPA*NAAEEP GRAAAAAAAAAGAAATPAPRQGLGGLRRGGGGAG SAGRGGRSPGPAMGLPEPGPLRLLALLLLLLLL LLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQC RNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCAD SDFTCDNGHCIHERWKCDGEEECPDGSDESEAT CTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDC EGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDG DDDCGDGSDERGCADPACGPREFRCGGDGGGAC IPERWVCDRQFDCEDRSDEAAELCGRPGPGATS APAACATASQFACRSGECVHLGWRCDGDRDCKDK SDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQE QDCPDGSDEAGCLQGLNECLHNNGGCSHICTDL KIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQ ICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKS PSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVA LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQ EVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTI SVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFM YWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNG ITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA NRLNGLEISILAENLNNPHDIVIFHELKQPRAPD ACELSVQPNGGCEYLCLPAPQISSHSPKYTCAC PDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTV PATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSV SVPRAPSISPSTLSPATSNHSQHYANEDSKMGS TVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRK NTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGH VYPAAISSFDRPLWAEPCLGETREPEDPAPALK ELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVA LSLEDDGLP*GWDHPLRASWNSVPCTTLWMVYDW MNGFLYMGLCECMCVCDFFFKFMLRKGNHKVMM NCKHPKDVRVFLCIMFYTLFNWLHYP*GIRGMA TAD*HDAHNQMGANGTVPYSSFKNYIYRRCLVAG GAFLGFGAFVFCK*DDYALWLSINISKKKKKTL QLPPPFRLFINIF*KSDEFYK*FREVRVFIFGM FGPPHRLCVCMCVFICVCV*QKNL*RRGTSMATV QIHKDKFIFTQSTRGISCSFQKSLWKSGSENRY HGLCNYVVKKANLFTSGYS*DPRKSGKAFQLTH GCCDSYQGFLGFGEGQCTDIPWYQSAQKLKIGYA SPSATPCFKVQLFE*LLQFLSGHLG*IQ*VSSE AP*RVPSLQS*VETFPDQPKFTIETGPGTECLG HAVDEDKDGGIGFITSLISLFPLLSTISFMWGNI LR**IGYLPSYVHIDETNFWLKSEQLAKIEVIF EGGNGIRNIILYWIFMFTQEFGLLLCK*KEKLR VY

Frame 1

LAAAAQGRGRAPSLSPPRRRASPNLLEMQPRSR GGRQRRRRRRRGQRQPRRRGKDSEG*DAAAAAR GARGAAAGAPGPPWASPSRALSGFWRCCCCCCCC CCCSSSILRRQRLIRCSAAKGRPRIAKRTNSSA GTSAASPLCGDATRTMTA*TTATRTTAPRRPVQ TVTSPVTTATASTNGGSVTARRSVLMAPMSPRPL APSRCVLQRS*AVDPPATSVYLPRGAATGRRTA RVERMRPAVLPCAPRTSSSAATARAWPPCSCAT ATTTVVTAAMSAAVQTRPAGPASSAAAAMAAAPA SRSAGSATASLTARTARTRQPSSAAVRAPGPRP RPPPAPPPPSSPAAAASACTWAGAATATATAKT NRTRPTAHWAPAVGTSSSVGMGHVSLQSSTATRS RTVQMGVMKLAAYRG*TSVCTTMAAAHTSALTS RLALNARAQQASSSWTRRPVATLMSARTQMPAA RSVSITRAILSVSATLATRWTY*PRTARLLLARA HP*SSPTGTRCGGSTW*SGTIHASSPCSRMSWH *MWKLPPIASTGVTSPTVRSIAPTWTRPVTRKS RRSSLTSSCTLQRAWQWTGSTSTSTGLTRAIRPS QWPQLMVAADALSSAVTSVNPGPSLLTPCEGSC IGLTGGTRPRLRNLGSTVWTGKHWCQTILNGPT ESPWIC*ASACTG*TPSYTNCPALTSVEATERR* SPPLTS*ATLLG*LCLRTRCSGQTWRTRPFSVQ IGSMAWKSPSWLRTSTTHMTLSSSMS*SSQELQ MPVS*VSSLMEAVNTCAFLLLRSPATLPSTHVPV LTQCGWVQT*RGATEHLNLPQLRR*LLP*RGQY LPPQEPPGPPSTDPPTRTTAQRHQA*QLQSQAQ LVSPGLPASARLP*ALQPATTPSTMQMKTVRWAQ QSLPLLSGSSCP*W**PSCA*VDT*SGETGSGR TPKA*ILTTQSTGKQQKKKTKMSSI*GELLRLA MSILQQSAALIAHCGQSPVLGRPENRKTQPLPSR SFLSCRGNQGHSCTNSRRTLFPSCLSSNPSEWH *ALKMMDYPEDGITPFVPHGIQSHALHSGWCMT G*MGFYIWVCVSVCVCVIFFLNLCCGKVTTKL** TANIQRM*EFFYV*CFIHFLTGCTTHEEFVEWL LLTNMMHITKWGPMAQYLTHHLKTIFTEDVWLL GGLF*VLGHLFFVNKMIMLCGYPST*VKKKKKHF NSLPHLDYLLTYFKNQMSSINNLEK*EYLFLAC LAHHTDSVCVCVCLYVYVCDRKICREEAHLWLL FKYIKINLFSHSPQGVYLVVFRKAFGNLDQKIDT MVCAIM**KRQIFSPLAIPETPGSQEKPFSSPM AAVTPTRAFLALAKVSVQTFHGTRVLRNSR*DM PHPQLLLVLKFSSLSNFFNFFQDTWVEFSKFPLK HPEGCHPYRAKWRRFQISPSLL*RLAQALNV*D MLWMKIKMVE*VLSHLLFLFSPYSLPFPLCGET F*GNK*VTYHHMFI*MKLIFGLSQNNWPKLKSYL RGEMAYAILYYIGYLCSHRNLVYCFVNKRKNSG YM

Frame 2

WRRPPRAGAARPA*ARPAAERHRTCLKCSRGAG AGGSGGGGGGGGSGNPGAAARTRRAETRRRRRG ERGARRPEPRARHGPPRAGPSPASGAAAAAAAA AAAAAPASCGGSG*SAARRPRAGQGLRKGPIPVP ERALHPLCVEMRRGR*LLRPQRRGRLPQEDLCR Q*LHL*QRPLHPRTVEV*RRGGVS*WLR*VRGH LHQAGVSCREAELWTHQPQVCTCLVALRRGEGLR GWSG*GRLCYLVRPARVPVRQPLVPGRRVRVRR RRRLW*RQR*ARLCRPGLRAPRVPLRRRWRRRL HPGALGLRPPV*LRGPLGRGSRALRPSGPRGHVR ARRLRHRLPVRLPQRRVRAPGLALRRRPRLQRQ IGRGRLPTGHLPWGRVPVWGWDMCPCNQALQPG AGLSRWE**SWLPTGAERVSAQQWRLLTHLH*PQ DWL*MHVPSRLPAPGPEDLWRH**VQGPRCLQP DLCQLQGLF*V*VLPWLRDGPTDQELQGCCWQE PIPNLHQPARGAEDRPGEAELFTPHPHAQECRGT RCGSCHQSHLLV*PLLP*DL*RLHGQGQ*PERA GGPH*RAVALSRGPGSGLGPQAHLLD*LGQ*DH LSGHS*WWPPTHSLQP*PQ*TPGHRC*PPARVHV LV*LGGPGQD*EIWAQRCGPANTGVRQY*MAQR NHPGSAEPALVLGRLQATPTVQH*LQWRQQKDA DLLH*LPEPPFWDSCV*GQGVLDRPGERGHFQCK SAQWPGNLHPG*EPQQPT*HCHLP*AEAAKSSR CL*AECPA*WRL*IPVPSCSSDLQPLSQVHMCL S*HNVAGSRHEEVLPSTSIYLNYDVSFYHDEDST CHHKSPRDHRPQIHLPEPQHRDTKPDSCSPKLS *CPQGSQHQPVYPKPCNQQPLPALCK*RQ*DGL NSHCRCYRDHRAHSGDSPPVHEWIPDLEKLEAEE HQKHEF*QPSLQENNRRRRRR*APYRENCSDWP CLSCSNQQL*SPTVGRALSWGDQRTGRPSPCPQ GAFCLAGGTKVTAAPTPEEPSFRAACRQIQASGI KP*R*WTTLRMGSPPSCLMEFSPMHYTLDGV*L DEWVSIYGSV*VYVCV*FFF*IYVAER*PQSYD ELQTSKGCESFSMYNVLYTF*LVALPMRNSWNGY C*LT*CT*PNGGQWHSTLLII*KLYLQKMFGCW GGFFRFWGICFL*IR*LCFVAIHQHK*KKKKNT STPSPI*IIY*HILKIR*VL*II*RSESIYFWHV WPTTQTLCVYVCVYMCMCVTEKSVEKRHIYGYC SNT*R*IYFHTVHKGYIL*FSEKPLEIWIRK*I PWFVQLCSKKGKSFHLWLFLRPQEVRKSLSAHPW LL*LLPGLSWLWRRSVYRHSMVPECSETQDRIC LTLSYSLF*SSAL*VTSSISFRTLGLNSVSFL* STLKGAILTELSGDVSRSAQVYYRDWPRH*MSRT CCG*R*RWWNRFYHISYFSFPLTLYHFLYVGKH FKVINRLLTIICSYR*N*FLA*VRTTGQN*SHI *GGKWHTQYYIILDIYVHTGIWFTAL*IKGKTPG IC