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Sequences

Sequence NM_001003681

TCCTTCTCCAAGATGGCGGCGATCGGCGGCGTTGAGGCGGGATCCGGGCGAGCCGAGTGAAGACCTGGTCCTGTAGACGGGAAGGAGCCTGGACACAGTG ACACATTCTCAAAGGCCCTGCAGGACCACCATGGCTTATGATGACTCCGTGAAGAAAGAAGATTGTTTTGATGGTGATCATACCTTTGAGGACATAGGAC TTGCAGCTGGCCGAAGCCAACGAGAGAAAAAACGTTCTTACAAAGATTTTTTAAGGGAAGAGGAAGAAATTGCTGCTCAGGTCAGGAATTCTTCCAAGAA GAAGTTGAAGGATAGTGAACTTTACTTCTTGGGGACGGACACACACAAGAAGAAGAGGAAGCACTCCTCTGATGATTACTACTATGGAGATATTTCGTCT TTGGAATCGTCACAGAAGAAAAAGAAAAAGTCCAGCCCACAGTCTACTGATACAGCTATGGACCTGTTGAAAGCTATCACTTCCCCACTGGCAGCAGGCT CCAAGCCCTCCAAAAAGACTGGGGAGAAATCCTCTGGCTCTTCAAGCCATTCGGAGAGTAAAAAGGAGCACCACAGGAAGAAAGTCAGTGGAAGCAGTGG GGAACTACCCCTAGAGGATGGTGGCTCCCACAAATCGAAAAAAATGAAACCTCTCTATGTGAACACAGAGACACTGACCCTTCGGGAGCCTGATGGTTTA AAAATGAAACTTATTCTGTCACCAAAGGAGAAGGGAAGCAGCTCTGTTGATGAGGAGTCTTTTCAATATCCCTCCCAACAAGCGACTGTGAAAAAATCCT CAAAGAAATCAGCTCGGGATGAGCAGGGTGCTTTACTCCTAGGACATGAGTTACAGAGCTTTCTGAAAACAGCCCGGAAAAAGCACAAGTCATCCTCAGA CGCACATTCATCTCCTGGCCCTGAAGGCTGTGGGTCTGACGCCTCCCAGTTCGCAGAGTCCCACAGTGCTAACCTTGATCTTTCAGGGCTTGAACCTATT CTGGTAGAATCAGACTCATCCTCTGGTGGGGAACTAGAGGCTGGGGAGTTAGTGATAGATGATTCTTACCGAGAAATCAAGAAGAAAAAGAAGTCAAAGA AGAGCAAAAAGAAGAAAGACAAGGAGAAGCATAAAGAGAAGCGACACTCCAAGTCCAAGAGAAGTTTAGGACTTTCTGCCGTGCCAGTGGGAGAGGTCAC AGTGACATCTGGCCCTCCTCCCAGCATCCCATACGCTGGAGCAGCAGCACCTCCCCTGCCACTTCCTGGCCTCCACACAGATGGGCATAGTGAAAAAAAA AAGAAAAAAGAAGAGAAGGACAAAGAGAGAGAGAGAGGAGAAAAGCCAAAAAAGAAGAACATGTCGGCCTACCAGGTGTTCTGTAAAGAGTATCGCGTGA CCATTGTGGCTGACCATCCAGGTATAGATTTTGGGGAACTTAGTAAAAAACTGGCTGAGGTGTGGAAGCAATTACCAGAAAAAGACAAACTGATTTGGAA GCAAAAAGCTCAGTATCTGCAGCACAAACAGAACAAAGCAGAAGCCACAACTGTGAAAAGGAAAGCATCCAGCTCAGAAGGTTCCATGAAAGTCAAAGCC TCTTCTGTAGGAGTACTGTCACCCCAGAAGAAGTCCCCACCCACCACCATGCTGTTACCAGCCTCACCAGCCAAAGCCCCTGAGACAGAGCCCATTGATG TTGCTGCTCATCTTCAGCTGTTGGGAGAGTCCCTAAGCCTCATTGGACACCGTCTGCAGGAAACTGAGGGTATGGTGGCTGTGTCTGGCAGTTTGTCAGT GCTTCTGGATTCCATTATCTGTGCCCTTGGCCCCTTGGCATGTCTCACCACACAACTACCTGAATTGAATGGCTGTCCCAAACAGGTCTTGTCAAACACA TTAGACAACATTGCTTACATCATGCCGGGACTGTGACAGCAAAGAATCCTGGGACAGAAACCTTATCCTACACCATTGCTGGTTTGTGTATATATGACTG TTGCAGATTCCTTCAGTGGCCTCTGGCTGTAGGTTTTAAATTTTTATATCTATACATACATATATACATATATATATAATGTACAATATATACATAGACT GTAACTACTTTGCTTTTAATAATTTTATGAAATGGCAAAGGTTTAGCCAAGAGGAAATTTTGGCATGAATACAGGCTTGGGATTCTTTTTTCTCCTGTGG TGGATAAATCTGCCTTAAAAATCAATGTAACTTGGGGGCTGGGGGCTTGTTCTGGGTGCCAAGCGCATCTCTTTATGGACAGCTAAAATGTGATTATTTT CCAAGCTCAGTTGGACCTCCAGACCCATCACTGACCATTTGCCTTACCTGTCTTAGTCTGAAATGTAATAGGAAAGATAACGGGAAGATGCCAGTTGACT GAAAATTCAAAGCCTTTCAATTTGAAGTGACCTAGGTGGGAGGTGATAAAATTTGTTCCCTTTATAGTTATGGAAGTGGCTTAGGTGAATTGAGTAGAGG GTTCATTCCAATTCCTACTGTATAGGTGTCTGTGTCTCAAAATTTATTGTAATCATTGGTACCATTGGTGGCCTCAACAGAGGCCAAGGAGTTCTGTGAG CCCTGGCAGCAAAAAACACCTTGGGGGGTGAAGCTGTCAATGCCACCAGTTGGACCTCCATACATTCTGAGCTAACCCAGAATCTTTAGTCGGCAGAATT AAGTGCTGGTGTCTTTCACTGGCAGCATGAAGTTAGCCACCAAGTCCTCACAAGCCGTGCTGCTTAGTTGCTCGGTGGTTATGGATAAACTTTGCCCAGC ATGATTTTTGGGTTCATCTTATCAGTTCCCCTGGTGGGCAGATACACAGTGTTCTGCATTCCACATGTAAGTGAATTGCAAAAACAAAACAAAACTCACT CTCTTGTAGGTTTATTTATGTGTGTGTGAATGTGTATTTTAATTATGTGTATTTAACTCTTTAAAATCTCTTAGATTTTAATTTATCCTGTAAATTTCTG TATATATAATTTAATAACAGAAGCCTCCACCAGCAACAGCATGTGGAAGATACAGATTTGTCATTTCTCCCTTCCGCCCTCCCTTCTTTCCTTCCTTCCT TCCCTGTTTCCTTCCCTCTTTCCTTCCTTCCTCCTGGTCTGTTCCAAAAACTCTGAATCATCTACATTTTAAGGTATTTTACCTCAAAAATGAATCATTG TGTTAGGATTCTAATTCTTTATAAAGAACTTCATGGGCTTCAATAATGTCTAGAAAGTAAAATAAAGAGGAATGTTACCATCCCCAGCTGCCCTTATTTC CAGAGAACCAGACGTTTGTTTCCCAGTTGGAAAGAAGACAGTTGAGCACTTCAGGATGGTTTTTAAATTTGGTATGAGATTCTCTGCCAACACCAAGCTC TGAGTTAACTGTGCTTTCTTCTCCTGGCCCTGACAGAGCACTACAGCATCAAAGTAAATCTTTGGGGACAGTGTAGCCCATCTGCATCCTATTTAATTTC TTCCCTTCTCCCCACCAGTGTTGTCACAGGGCTATGTTGCTTAAAGGTAGTCTGGCTGCTGAATCCCTTTCTCAGCTCAGAGCAGTTTTAAGATTTAATT GGGAATACAGAGAAACAGGATTGTTTGAGAACCAAAATCAAGAGGAACAGAAATCTTAACTTGATTTCATGTGTTAGAACATTGTACCATGCCTCTTCTG TATCTGTGGAAGTTTCCTGTTTGACACAGGGTATCTAGGAGGGGCGGGGAAGACATGGATAGTATAGGAAGACATTAATCCTAGCATTGTCATTTATATA CATTAATGAAATCCTGATGAGGACCTGCTTTTTGTTTGTTTTCCTTTGAAACCCAGCCCTATTGTATTTGTATTTAAAATTTGTACACATTTGTATAATA ATCTGTACCTTGTGGTATTTGGTACTATTAGAGGAAAAACTTTGGATTCAGACCTTCTTGCAGTTTTTATATCATTGTTTTATTTTGTTTTTTAAATAAA TTCTAGTGGTTTGATCCAAATCCCATTACAGTTGTATAAAGAAATAAAATTTTGTACTTATATTATTAAAAATCACATTTTTAATATTTGTA

refseq_HMG2L1.F1 (forward primer)
refseq_HMG2L1.R1 (reverse primer)
Single exon skipping

Frame 0

SFSKMAAIGGVEAGSGRAE*RPGPVDGKEPGHS DTFSKALQDHHGL**LREERRLF*W*SYL*GHRT CSWPKPTREKTFLQRFFKGRGRNCCSGQEFFQE EVEG**TLLLGDGHTQEEEEALL**LLLWRYFV FGIVTEEKEKVQPTVY*YSYGPVESYHFPTGSRL QALQKDWGEILWLFKPFGE*KGAPQEESQWKQW GTTPRGWWLPQIEKNETSLCEHRDTDPSGA*WF KNETYSVTKGEGKQLC**GVFSISLPTSDCEKIL KEISSG*AGCFTPRT*VTELSENSPEKAQVILR RTFISWP*RLWV*RLPVRRVPQC*P*SFRA*TY SGRIRLILWWGTRGWGVSDR*FLPRNQEEKEVKE EQKEERQGEA*REATLQVQEKFRTFCRASGRGH SDIWPSSQHPIRWSSSTSPATSWPPHRWA**KK KEKRREGQRERERRKAKKEEHVGLPGVL*RVSRD HCG*PSRYRFWGT**KTG*GVEAITRKRQTDLE AKSSVSAAQTEQSRSHNCEKESIQLRRFHESQS LFCRSTVTPEEVPTHHHAVTSLTSQSP*DRAH*C CCSSSAVGRVPKPHWTPSAGN*GYGGCVWQFVS ASGFHYLCPWPLGMSHHTTT*IEWLSQTGLVKH IRQHCLHHAGTVTAKNPGTETLSYTIAGLCIYDC CRFLQWPLAVGFKFLYLYIHIYIYI*CTIYT*T VTTLLLIIL*NGKGLAKRKFWHEYRLGILFSPV VDKSALKINVTWGLGACSGCQAHLFMDS*NVIIF QAQLDLQTHH*PFALPVLV*NVIGKITGRCQLT ENSKPFNLK*PRWEVIKFVPFIVMEVA*VN*VE GSFQFLLYRCLCLKIYCNHWYHWWPQQRPRSSVS PGSKKHLGG*SCQCHQLDLHTF*ANPESLVGRI KCWCLSLAA*S*PPSPHKPCCLVARWLWINFAQ HDFWVHLISSPGGQIHSVLHSTCK*IAKTKQNSL SCRFIYVCVNVYFNYVYLTL*NLLDFNLSCKFL YI*FNNRSLHQQQHVEDTDLSFLPSALPSFLPS FPVSFPLSFLPPGLFQKL*IIYILRYFTSKMNHC VRILILYKELHGLQ*CLESKIKRNVTIPSCPYF QRTRRLFPSWKEDS*ALQDGF*IWYEILCQHQA LS*LCFLLLALTEHYSIKVNLWGQCSPSASYLIS SLLPTSVVTGLCCLKVVWLLNPFLSSEQF*DLI GNTEKQDCLRTKIKRNRNLNLISCVRTLYHASS VSVEVSCLTQGI*EGRGRHG*YRKTLILALSFIY INEILMRTCFLFVFL*NPALLYLYLKFVHICII ICTLWYLVLLEEKLWIQTFLQFLYHCFILFFK* ILVV*SKSHYSCIKK*NFVLILLKITFLIFV

Frame 1

PSPRWRRSAALRRDPGEPSEDLVL*TGRSLDTV THSQRPCRTTMAYDDSVKKEDCFDGDHTFEDIG LAAGRSQREKKRSYKDFLREEEEIAAQVRNSSKK KLKDSELYFLGTDTHKKKRKHSSDDYYYGDISS LESSQKKKKKSSPQSTDTAMDLLKAITSPLAAG SKPSKKTGEKSSGSSSHSESKKEHHRKKVSGSSG ELPLEDGGSHKSKKMKPLYVNTETLTLREPDGL KMKLILSPKEKGSSSVDEESFQYPSQQATVKKS SKKSARDEQGALLLGHELQSFLKTARKKHKSSSD AHSSPGPEGCGSDASQFAESHSANLDLSGLEPI LVESDSSSGGELEAGELVIDDSYREIKKKKKSK KSKKKKDKEKHKEKRHSKSKRSLGLSAVPVGEVT VTSGPPPSIPYAGAAAPPLPLPGLHTDGHSEKK KKKEEKDKERERGEKPKKKNMSAYQVFCKEYRV TIVADHPGIDFGELSKKLAEVWKQLPEKDKLIWK QKAQYLQHKQNKAEATTVKRKASSSEGSMKVKA SSVGVLSPQKKSPPTTMLLPASPAKAPETEPID VAAHLQLLGESLSLIGHRLQETEGMVAVSGSLSV LLDSIICALGPLACLTTQLPELNGCPKQVLSNT LDNIAYIMPGL*QQRILGQKPYPTPLLVCVYMT VADSFSGLWL*VLNFYIYTYIYTYIYNVQYIHRL *LLCF**FYEMAKV*PRGNFGMNTGLGFFFLLW WINLP*KSM*LGGWGLVLGAKRISLWTAKM*LF SKLSWTSRPITDHLPYLS*SEM**ER*REDAS*L KIQSLSI*SDLGGR**NLFPL*LWKWLR*IE*R VHSNSYCIGVCVSKFIVIIGTIGGLNRGQGVL* ALAAKNTLGGEAVNATSWTSIHSELTQNL*SAEL SAGVFHWQHEVSHQVLTSRAA*LLGGYG*TLPS MIFGFILSVPLVGRYTVFCIPHVSELQKQNKTH SLVGLFMCV*MCILIMCI*LFKIS*ILIYPVNFC IYNLITEASTSNSMWKIQICHFSLPPSLLSFLP SLFPSLFPSFLLVCSKNSESSTF*GILPQK*II VLGF*FFIKNFMGFNNV*KVK*RGMLPSPAALIS REPDVCFPVGKKTVEHFRMVFKFGMRFSANTKL *VNCAFFSWP*QSTTASK*IFGDSVAHLHPI*F LPFSPPVLSQGYVA*R*SGC*IPFSAQSSFKI*L GIQRNRIV*EPKSRGTEILT*FHVLEHCTMPLL YLWKFPV*HRVSRRGGEDMDSIGRH*S*HCHLY TLMKS**GPAFCLFSFETQPYCICI*NLYTFV** SVPCGIWYY*RKNFGFRPSCSFYIIVLFCFLNK F*WFDPNPITVV*RNKILYLYY*KSHF*YL

Frame 2

LLQDGGDRRR*GGIRASRVKTWSCRREGAWTQ* HILKGPAGPPWLMMTP*RKKIVLMVIIPLRT*D LQLAEANERKNVLTKIF*GKRKKLLLRSGILPR RS*RIVNFTSWGRTHTRRRGSTPLMITTMEIFRL WNRHRRKRKSPAHSLLIQLWTC*KLSLPHWQQA PSPPKRLGRNPLALQAIRRVKRSTTGRKSVEAV GNYP*RMVAPTNRKK*NLSM*TQRH*PFGSLMV* K*NLFCHQRRREAALLMRSLFNIPPNKRL*KNP QRNQLGMSRVLYS*DMSYRAF*KQPGKSTSHPQ THIHLLALKAVGLTPPSSQSPTVLTLIFQGLNLF W*NQTHPLVGN*RLGS***MILTEKSRRKRSQR RAKRRKTRRSIKRSDTPSPREV*DFLPCQWERS Q*HLALLPASHTLEQQHLPCHFLASTQMGIVKKK RKKKRRTKREREEKSQKRRTCRPTRCSVKSIA* PLWLTIQV*ILGNLVKNWLRCGSNYQKKTN*FG SKKLSICSTNRTKQKPQL*KGKHPAQKVP*KSKP LL*EYCHPRRSPHPPPCCYQPHQPKPLRQSPLM LLLIFSCWESP*ASLDTVCRKLRVWWLCLAVCQ CFWIPLSVPLAPWHVSPHNYLN*MAVPNRSCQTH *TTLLTSCRDCDSKESWDRNLILHHCWFVYI*L LQIPSVASGCRF*IFISIHTYIHIYIMYNIYID CNYFAFNNFMKWQRFSQEEILA*IQAWDSFFSCG G*ICLKNQCNLGAGGLFWVPSASLYGQLKCDYF PSSVGPPDPSLTICLTCLSLKCNRKDNGKMPVD *KFKAFQFEVT*VGGDKICSLYSYGSGLGELSRG FIPIPTV*VSVSQNLL*SLVPLVASTEAKEFCE PWQQKTPWGVKLSMPPVGPPYILS*PRIFSRQN *VLVSFTGSMKLATKSSQAVLLSCSVVMDKLCPA *FLGSSYQFPWWADTQCSAFHM*VNCKNKTKLT LL*VYLCVCECVF*LCVFNSLKSLRF*FIL*IS VYII**QKPPPATACGRYRFVISPFRPPFFPSFL PCFLPSFLPSSWSVPKTLNHLHFKVFYLKNESL C*DSNSL*RTSWASIMSRK*NKEECYHPQLPLF PENQTFVSQLERRQLSTSGWFLNLV*DSLPTPSS ELTVLSSPGPDRALQHQSKSLGTV*PICILFNF FPSPHQCCHRAMLLKGSLAAESLSQLRAVLRFN WEYRETGLFENQNQEEQKS*LDFMC*NIVPCLFC ICGSFLFDTGYLGGAGKTWIV*EDINPSIVIYI H**NPDEDLLFVCFPLKPSPIVFVFKICTHLYN NLYLVVFGTIRGKTLDSDLLAVFISLFYFVF*IN SSGLIQIPLQLYKEIKFCTYIIKNHIFNIC

Sequence NM_014250

TCCTTCTCCAAGATGGCGGCGATCGGCGGCGTTGAGGCGGGATCCGGGCGAGCCGAGTGAAGATTGTTTTGATGGTGATCATACCTTTGAGGACATAGGA CTTGCAGCTGGCCGAAGCCAACGAGAGAAAAAACGTTCTTACAAAGATTTTTTAAGGGAAGAGGAAGAAATTGCTGCTCAGGTCAGGAATTCTTCCAAGA AGAAGTTGAAGGATAGTGAACTTTACTTCTTGGGGACGGACACACACAAGAAGAAGAGGAAGCACTCCTCTGATGATTACTACTATGGAGGACAGTGGTT CTTGTTCTGAGTGCCGATAAACCAGTGTGAAGGAGGAGAGAGGTGGAGGGCTGGTATTTTGGAGGATTCAGCATAGAAGAACAGTCTGCATTTGTGATAC ACCAGATATTTCGTCTTTGGAATCGTCACAGAAGAAAAAGAAAAAGTCCAGCCCACAGTCTACTGATACAGCTATGGACCTGTTGAAAGCTATCACTTCC CCACTGGCAGCAGGCTCCAAGCCCTCCAAAAAGACTGGGGAGAAATCCTCTGGCTCTTCAAGCCATTCGGAGAGTAAAAAGGAGCACCACAGGAAGAAAG TCAGTGGAAGCAGTGGGGAACTACCCCTAGAGGATGGTGGCTCCCACAAATCGAAAAAAATGAAACCTCTCTATGTGAACACAGAGACACTGACCCTTCG GGAGCCTGATGGTTTAAAAATGAAACTTATTCTGTCACCAAAGGAGAAGGGAAGCAGCTCTGTTGATGAGGAGTCTTTTCAATATCCCTCCCAACAAGCG ACTGTGAAAAAATCCTCAAAGAAATCAGCTCGGGATGAGCAGGGTGCTTTACTCCTAGGACATGAGTTACAGAGCTTTCTGAAAACAGCCCGGAAAAAGC ACAAGTCATCCTCAGACGCACATTCATCTCCTGGCCCTGAAGGCTGTGGGTCTGACGCCTCCCAGTTCGCAGAGTCCCACAGTGCTAACCTTGATCTTTC AGGGCTTGAACCTATTCTGGTAGAATCAGACTCATCCTCTGGTGGGGAACTAGAGGCTGGGGAGTTAGTGATAGATGATTCTTACCGAGAAATCAAGAAG AAAAAGAAGTCAAAGAAGAGCAAAAAGAAGAAAGACAAGGAGAAGCATAAAGAGAAGCGACACTCCAAGTCCAAGAGAAGTTTAGGACTTTCTGCCGTGC CAGTGGGAGAGGTCACAGTGACATCTGGCCCTCCTCCCAGCATCCCATACGCTGGAGCAGCAGCACCTCCCCTGCCACTTCCTGGCCTCCACACAGATGG GCATAGTGAAAAAAAAAAGAAAAAAGAAGAGAAGGACAAAGAGAGAGAGAGAGGAGAAAAGCCAAAAAAGAAGAACATGTCGGCCTACCAGGTGTTCTGT AAAGAGTATCGCGTGACCATTGTGGCTGACCATCCAGGTATAGATTTTGGGGAACTTAGTAAAAAACTGGCTGAGGTGTGGAAGCAATTACCAGAAAAAG ACAAACTGATTTGGAAGCAAAAAGCTCAGTATCTGCAGCACAAACAGAACAAAGCAGAAGCCACAACTGTGAAAAGGAAAGCATCCAGCTCAGAAGGTTC CATGAAAGTCAAAGCCTCTTCTGTAGGAGTACTGTCACCCCAGAAGAAGTCCCCACCCACCACCATGCTGTTACCAGCCTCACCAGCCAAAGCCCCTGAG ACAGAGCCCATTGATGTTGCTGCTCATCTTCAGCTGTTGGGAGAGTCCCTAAGCCTCATTGGACACCGTCTGCAGGAAACTGAGGGTATGGTGGCTGTGT CTGGCAGTTTGTCAGTGCTTCTGGATTCCATTATCTGTGCCCTTGGCCCCTTGGCATGTCTCACCACACAACTACCTGAATTGAATGGCTGTCCCAAACA GGTCTTGTCAAACACATTAGACAACATTGCTTACATCATGCCGGGACTGTGACAGCAAAGAATCCTGGGACAGAAACCTTATCCTACACCATTGCTGGTT TGTGTATATATGACTGTTGCAGATTCCTTCAGTGGCCTCTGGCTGTAGGTTTTAAATTTTTATATCTATACATACATATATACATATATATATAATGTAC AATATATACATAGACTGTAACTACTTTGCTTTTAATAATTTTATGAAATGGCAAAGGTTTAGCCAAGAGGAAATTTTGGCATGAATACAGGCTTGGGATT CTTTTTTCTCCTGTGGTGGATAAATCTGCCTTAAAAATCAATGTAACTTGGGGGCTGGGGGCTTGTTCTGGGTGCCAAGCGCATCTCTTTATGGACAGCT AAAATGTGATTATTTTCCAAGCTCAGTTGGACCTCCAGACCCATCACTGACCATTTGCCTTACCTGTCTTAGTCTGAAATGTAATAGGAAAGATAACGGG AAGATGCCAGTTGACTGAAAATTCAAAGCCTTTCAATTTGAAGTGACCTAGGTGGGAGGTGATAAAATTTGTTCCCTTTATAGTTATGGAAGTGGCTTAG GTGAATTGAGTAGAGGGTTCATTCCAATTCCTACTGTATAGGTGTCTGTGTCTCAAAATTTATTGTAATCATTGGTACCATTGGTGGCCTCAACAGAGGC CAAGGAGTTCTGTGAGCCCTGGCAGCAAAAAACACCTTGGGGGGTGAAGCTGTCAATGCCACCAGTTGGACCTCCATACATTCTGAGCTAACCCAGAATC TTTAGTCGGCAGAATTAAGTGCTGGTGTCTTTCACTGGCAGCATGAAGTTAGCCACCAAGTCCTCACAAGCCGTGCTGCTTAGTTGCTCGGTGGTTATGG ATAAACTTTGCCCAGCATGATTTTTGGGTTCATCTTATCAGTTCCCCTGGTGGGCAGATACACAGTGTTCTGCATTCCACATGTAAGTGAATTGCAAAAA CAAAACAAAACTCACTCTCTTGTAGGTTTATTTATGTGTGTGTGAATGTGTATTTTAATTATGTGTATTTAACTCTTTAAAATCTCTTAGATTTTAATTT ATCCTGTAAATTTCTGTATATATAATTTAATAACAGAAGCCTCCACCAGCAACAGCATGTGGAAGATACAGATTTGTCATTTCTCCCTTCCGCCCTCCCT TCTTTCCTTCCTTCCTTCCCTGTTTCCTTCCCTCTTTCCTTCCTTCCTCCTGGTCTGTTCCAAAAACTCTGAATCATCTACATTTTAAGGTATTTTACCT CAAAAATGAATCATTGTGTTAGGATTCTAATTCTTTATAAAGAACTTCATGGGCTTCAATAATGTCTAGAAAGTAAAATAAAGAGGAATGTTACCATCCC CAGCTGCCCTTATTTCCAGAGAACCAGACGTTTGTTTCCCAGTTGGAAAGAAGACAGTTGAGCACTTCAGGATGGTTTTTAAATTTGGTATGAGATTCTC TGCCAACACCAAGCTCTGAGTTAACTGTGCTTTCTTCTCCTGGCCCTGACAGAGCACTACAGCATCAAAGTAAATCTTTGGGGACAGTGTAGCCCATCTG CATCCTATTTAATTTCTTCCCTTCTCCCCACCAGTGTTGTCACAGGGCTATGTTGCTTAAAGGTAGTCTGGCTGCTGAATCCCTTTCTCAGCTCAGAGCA GTTTTAAGATTTAATTGGGAATACAGAGAAACAGGATTGTTTGAGAACCAAAATCAAGAGGAACAGAAATCTTAACTTGATTTCATGTGTTAGAACATTG TACCATGCCTCTTCTGTATCTGTGGAAGTTTCCTGTTTGACACAGGGTATCTAGGAGGGGCGGGGAAGACATGGATAGTATAGGAAGACATTAATCCTAG CATTGTCATTTATATACATTAATGAAATCCTGATGAGGACCTGCTTTTTGTTTGTTTTCCTTTGAAACCCAGCCCTATTGTATTTGTATTTAAAATTTGT ACACATTTGTATAATAATCTGTACCTTGTGGTATTTGGTACTATTAGAGGAAAAACTTTGGATTCAGACCTTCTTGCAGTTTTTATATCATTGTTTTATT TTGTTTTTTAAATAAATTCTAGTGGTTTGATCCAAATCCCATTACAGTTGTATAAAGAAATAAAATTTTGTACTTATATTATTAAAAATCACATTTTTAA TATTTGTA

refseq_HMG2L1.F1 (forward primer)
refseq_HMG2L1.R1 (reverse primer)
Single exon skipping

Frame 0

SFSKMAAIGGVEAGSGRAE*RLF*W*SYL*GHR TCSWPKPTREKTFLQRFFKGRGRNCCSGQEFFQE EVEG**TLLLGDGHTQEEEEALL**LLLWRTVV LVLSADKPV*RRREVEGWYFGGFSIEEQSAFVI HQIFRLWNRHRRKRKSPAHSLLIQLWTC*KLSLP HWQQAPSPPKRLGRNPLALQAIRRVKRSTTGRK SVEAVGNYP*RMVAPTNRKK*NLSM*TQRH*PF GSLMV*K*NLFCHQRRREAALLMRSLFNIPPNKR L*KNPQRNQLGMSRVLYS*DMSYRAF*KQPGKS TSHPQTHIHLLALKAVGLTPPSSQSPTVLTLIF QGLNLFW*NQTHPLVGN*RLGS***MILTEKSRR KRSQRRAKRRKTRRSIKRSDTPSPREV*DFLPC QWERSQ*HLALLPASHTLEQQHLPCHFLASTQM GIVKKKRKKKRRTKREREEKSQKRRTCRPTRCSV KSIA*PLWLTIQV*ILGNLVKNWLRCGSNYQKK TN*FGSKKLSICSTNRTKQKPQL*KGKHPAQKV P*KSKPLL*EYCHPRRSPHPPPCCYQPHQPKPLR QSPLMLLLIFSCWESP*ASLDTVCRKLRVWWLC LAVCQCFWIPLSVPLAPWHVSPHNYLN*MAVPN RSCQTH*TTLLTSCRDCDSKESWDRNLILHHCWF VYI*LLQIPSVASGCRF*IFISIHTYIHIYIMY NIYIDCNYFAFNNFMKWQRFSQEEILA*IQAWD SFFSCGG*ICLKNQCNLGAGGLFWVPSASLYGQL KCDYFPSSVGPPDPSLTICLTCLSLKCNRKDNG KMPVD*KFKAFQFEVT*VGGDKICSLYSYGSGL GELSRGFIPIPTV*VSVSQNLL*SLVPLVASTEA KEFCEPWQQKTPWGVKLSMPPVGPPYILS*PRI FSRQN*VLVSFTGSMKLATKSSQAVLLSCSVVM DKLCPA*FLGSSYQFPWWADTQCSAFHM*VNCKN KTKLTLL*VYLCVCECVF*LCVFNSLKSLRF*F IL*ISVYII**QKPPPATACGRYRFVISPFRPP FFPSFLPCFLPSFLPSSWSVPKTLNHLHFKVFYL KNESLC*DSNSL*RTSWASIMSRK*NKEECYHP QLPLFPENQTFVSQLERRQLSTSGWFLNLV*DS LPTPSSELTVLSSPGPDRALQHQSKSLGTV*PIC ILFNFFPSPHQCCHRAMLLKGSLAAESLSQLRA VLRFNWEYRETGLFENQNQEEQKS*LDFMC*NI VPCLFCICGSFLFDTGYLGGAGKTWIV*EDINPS IVIYIH**NPDEDLLFVCFPLKPSPIVFVFKIC THLYNNLYLVVFGTIRGKTLDSDLLAVFISLFY FVF*INSSGLIQIPLQLYKEIKFCTYIIKNHIFN IC

Frame 1

PSPRWRRSAALRRDPGEPSEDCFDGDHTFEDIG LAAGRSQREKKRSYKDFLREEEEIAAQVRNSSK KKLKDSELYFLGTDTHKKKRKHSSDDYYYGGQWF LF*VPINQCEGGERWRAGILEDSA*KNSLHL*Y TRYFVFGIVTEEKEKVQPTVY*YSYGPVESYHF PTGSRLQALQKDWGEILWLFKPFGE*KGAPQEES QWKQWGTTPRGWWLPQIEKNETSLCEHRDTDPS GA*WFKNETYSVTKGEGKQLC**GVFSISLPTS DCEKILKEISSG*AGCFTPRT*VTELSENSPEKA QVILRRTFISWP*RLWV*RLPVRRVPQC*P*SF RA*TYSGRIRLILWWGTRGWGVSDR*FLPRNQE EKEVKEEQKEERQGEA*REATLQVQEKFRTFCRA SGRGHSDIWPSSQHPIRWSSSTSPATSWPPHRW A**KKKEKRREGQRERERRKAKKEEHVGLPGVL *RVSRDHCG*PSRYRFWGT**KTG*GVEAITRKR QTDLEAKSSVSAAQTEQSRSHNCEKESIQLRRF HESQSLFCRSTVTPEEVPTHHHAVTSLTSQSP* DRAH*CCCSSSAVGRVPKPHWTPSAGN*GYGGCV WQFVSASGFHYLCPWPLGMSHHTTT*IEWLSQT GLVKHIRQHCLHHAGTVTAKNPGTETLSYTIAG LCIYDCCRFLQWPLAVGFKFLYLYIHIYIYI*CT IYT*TVTTLLLIIL*NGKGLAKRKFWHEYRLGI LFSPVVDKSALKINVTWGLGACSGCQAHLFMDS *NVIIFQAQLDLQTHH*PFALPVLV*NVIGKITG RCQLTENSKPFNLK*PRWEVIKFVPFIVMEVA* VN*VEGSFQFLLYRCLCLKIYCNHWYHWWPQQR PRSSVSPGSKKHLGG*SCQCHQLDLHTF*ANPES LVGRIKCWCLSLAA*S*PPSPHKPCCLVARWLW INFAQHDFWVHLISSPGGQIHSVLHSTCK*IAK TKQNSLSCRFIYVCVNVYFNYVYLTL*NLLDFNL SCKFLYI*FNNRSLHQQQHVEDTDLSFLPSALP SFLPSFPVSFPLSFLPPGLFQKL*IIYILRYFT SKMNHCVRILILYKELHGLQ*CLESKIKRNVTIP SCPYFQRTRRLFPSWKEDS*ALQDGF*IWYEIL CQHQALS*LCFLLLALTEHYSIKVNLWGQCSPS ASYLISSLLPTSVVTGLCCLKVVWLLNPFLSSEQ F*DLIGNTEKQDCLRTKIKRNRNLNLISCVRTL YHASSVSVEVSCLTQGI*EGRGRHG*YRKTLIL ALSFIYINEILMRTCFLFVFL*NPALLYLYLKFV HICIIICTLWYLVLLEEKLWIQTFLQFLYHCFI LFFK*ILVV*SKSHYSCIKK*NFVLILLKITFL IFV

Frame 2

LLQDGGDRRR*GGIRASRVKIVLMVIIPLRT*D LQLAEANERKNVLTKIF*GKRKKLLLRSGILPR RS*RIVNFTSWGRTHTRRRGSTPLMITTMEDSG SCSECR*TSVKEERGGGLVFWRIQHRRTVCICDT PDISSLESSQKKKKKSSPQSTDTAMDLLKAITS PLAAGSKPSKKTGEKSSGSSSHSESKKEHHRKK VSGSSGELPLEDGGSHKSKKMKPLYVNTETLTLR EPDGLKMKLILSPKEKGSSSVDEESFQYPSQQA TVKKSSKKSARDEQGALLLGHELQSFLKTARKK HKSSSDAHSSPGPEGCGSDASQFAESHSANLDLS GLEPILVESDSSSGGELEAGELVIDDSYREIKK KKKSKKSKKKKDKEKHKEKRHSKSKRSLGLSAV PVGEVTVTSGPPPSIPYAGAAAPPLPLPGLHTDG HSEKKKKKEEKDKERERGEKPKKKNMSAYQVFC KEYRVTIVADHPGIDFGELSKKLAEVWKQLPEK DKLIWKQKAQYLQHKQNKAEATTVKRKASSSEGS MKVKASSVGVLSPQKKSPPTTMLLPASPAKAPE TEPIDVAAHLQLLGESLSLIGHRLQETEGMVAV SGSLSVLLDSIICALGPLACLTTQLPELNGCPKQ VLSNTLDNIAYIMPGL*QQRILGQKPYPTPLLV CVYMTVADSFSGLWL*VLNFYIYTYIYTYIYNV QYIHRL*LLCF**FYEMAKV*PRGNFGMNTGLGF FFLLWWINLP*KSM*LGGWGLVLGAKRISLWTA KM*LFSKLSWTSRPITDHLPYLS*SEM**ER*R EDAS*LKIQSLSI*SDLGGR**NLFPL*LWKWLR *IE*RVHSNSYCIGVCVSKFIVIIGTIGGLNRG QGVL*ALAAKNTLGGEAVNATSWTSIHSELTQN L*SAELSAGVFHWQHEVSHQVLTSRAA*LLGGYG *TLPSMIFGFILSVPLVGRYTVFCIPHVSELQK QNKTHSLVGLFMCV*MCILIMCI*LFKIS*ILI YPVNFCIYNLITEASTSNSMWKIQICHFSLPPSL LSFLPSLFPSLFPSFLLVCSKNSESSTF*GILP QK*IIVLGF*FFIKNFMGFNNV*KVK*RGMLPS PAALISREPDVCFPVGKKTVEHFRMVFKFGMRFS ANTKL*VNCAFFSWP*QSTTASK*IFGDSVAHL HPI*FLPFSPPVLSQGYVA*R*SGC*IPFSAQS SFKI*LGIQRNRIV*EPKSRGTEILT*FHVLEHC TMPLLYLWKFPV*HRVSRRGGEDMDSIGRH*S* HCHLYTLMKS**GPAFCLFSFETQPYCICI*NL YTFV**SVPCGIWYY*RKNFGFRPSCSFYIIVLF CFLNKF*WFDPNPITVV*RNKILYLYY*KSHF* YL

Sequence NM_005487

TCCTTCTCCAAGATGGCGGCGATCGGCGGCGTTGAGGCGGGATCCGGGCGAGCCGAGTGAAGACCTGGTCCTGTAGACGGGAAGGAGCCTGGACACAGTG ACACATTCTCAAAGGCCCTGCAGGACCACCATGGCTTATGATGACTCCGTGAAGAAAGAAGATTGTTTTGATGGTGATCATACCTTTGAGGACATAGGAC TTGCAGCTGGCCGAAGCCAACGAGAGAAAAAACGTTCTTACAAAGATTTTTTAAGGGAAGAGGAAGAAATTGCTGCTCAGGTCAGGAATTCTTCCAAGAA GAAGTTGAAGGATAGTGAACTTTACTTCTTGGGGACGGACACACACAAGAAGAAGAGGAAGCACTCCTCTGATGATTACTACTATGGAGGACAGTGGTTC TTGTTCTGAGTGCCGATAAACCAGTGTGAAGGAGGAGAGAGGTGGAGGGCTGGTATTTTGGAGGATTCAGCATAGAAGAACAGTCTGCATTTGTGATACA CCAGATATTTCGTCTTTGGAATCGTCACAGAAGAAAAAGAAAAAGTCCAGCCCACAGTCTACTGATACAGCTATGGACCTGTTGAAAGCTATCACTTCCC CACTGGCAGCAGGCTCCAAGCCCTCCAAAAAGACTGGGGAGAAATCCTCTGGCTCTTCAAGCCATTCGGAGAGTAAAAAGGAGCACCACAGGAAGAAAGT CAGTGGAAGCAGTGGGGAACTACCCCTAGAGGATGGTGGCTCCCACAAATCGAAAAAAATGAAACCTCTCTATGTGAACACAGAGACACTGACCCTTCGG GAGCCTGATGGTTTAAAAATGAAACTTATTCTGTCACCAAAGGAGAAGGGAAGCAGCTCTGTTGATGAGGAGTCTTTTCAATATCCCTCCCAACAAGCGA CTGTGAAAAAATCCTCAAAGAAATCAGCTCGGGATGAGCAGGGTGCTTTACTCCTAGGACATGAGTTACAGAGCTTTCTGAAAACAGCCCGGAAAAAGCA CAAGTCATCCTCAGACGCACATTCATCTCCTGGCCCTGAAGGCTGTGGGTCTGACGCCTCCCAGTTCGCAGAGTCCCACAGTGCTAACCTTGATCTTTCA GGGCTTGAACCTATTCTGGTAGAATCAGACTCATCCTCTGGTGGGGAACTAGAGGCTGGGGAGTTAGTGATAGATGATTCTTACCGAGAAATCAAGAAGA AAAAGAAGTCAAAGAAGAGCAAAAAGAAGAAAGACAAGGAGAAGCATAAAGAGAAGCGACACTCCAAGTCCAAGAGAAGTTTAGGACTTTCTGCCGTGCC AGTGGGAGAGGTCACAGTGACATCTGGCCCTCCTCCCAGCATCCCATACGCTGGAGCAGCAGCACCTCCCCTGCCACTTCCTGGCCTCCACACAGATGGG CATAGTGAAAAAAAAAAGAAAAAAGAAGAGAAGGACAAAGAGAGAGAGAGAGGAGAAAAGCCAAAAAAGAAGAACATGTCGGCCTACCAGGTGTTCTGTA AAGAGTATCGCGTGACCATTGTGGCTGACCATCCAGGTATAGATTTTGGGGAACTTAGTAAAAAACTGGCTGAGGTGTGGAAGCAATTACCAGAAAAAGA CAAACTGATTTGGAAGCAAAAAGCTCAGTATCTGCAGCACAAACAGAACAAAGCAGAAGCCACAACTGTGAAAAGGAAAGCATCCAGCTCAGAAGGTTCC ATGAAAGTCAAAGCCTCTTCTGTAGGAGTACTGTCACCCCAGAAGAAGTCCCCACCCACCACCATGCTGTTACCAGCCTCACCAGCCAAAGCCCCTGAGA CAGAGCCCATTGATGTTGCTGCTCATCTTCAGCTGTTGGGAGAGTCCCTAAGCCTCATTGGACACCGTCTGCAGGAAACTGAGGGTATGGTGGCTGTGTC TGGCAGTTTGTCAGTGCTTCTGGATTCCATTATCTGTGCCCTTGGCCCCTTGGCATGTCTCACCACACAACTACCTGAATTGAATGGCTGTCCCAAACAG GTCTTGTCAAACACATTAGACAACATTGCTTACATCATGCCGGGACTGTGACAGCAAAGAATCCTGGGACAGAAACCTTATCCTACACCATTGCTGGTTT GTGTATATATGACTGTTGCAGATTCCTTCAGTGGCCTCTGGCTGTAGGTTTTAAATTTTTATATCTATACATACATATATACATATATATATAATGTACA ATATATACATAGACTGTAACTACTTTGCTTTTAATAATTTTATGAAATGGCAAAGGTTTAGCCAAGAGGAAATTTTGGCATGAATACAGGCTTGGGATTC TTTTTTCTCCTGTGGTGGATAAATCTGCCTTAAAAATCAATGTAACTTGGGGGCTGGGGGCTTGTTCTGGGTGCCAAGCGCATCTCTTTATGGACAGCTA AAATGTGATTATTTTCCAAGCTCAGTTGGACCTCCAGACCCATCACTGACCATTTGCCTTACCTGTCTTAGTCTGAAATGTAATAGGAAAGATAACGGGA AGATGCCAGTTGACTGAAAATTCAAAGCCTTTCAATTTGAAGTGACCTAGGTGGGAGGTGATAAAATTTGTTCCCTTTATAGTTATGGAAGTGGCTTAGG TGAATTGAGTAGAGGGTTCATTCCAATTCCTACTGTATAGGTGTCTGTGTCTCAAAATTTATTGTAATCATTGGTACCATTGGTGGCCTCAACAGAGGCC AAGGAGTTCTGTGAGCCCTGGCAGCAAAAAACACCTTGGGGGGTGAAGCTGTCAATGCCACCAGTTGGACCTCCATACATTCTGAGCTAACCCAGAATCT TTAGTCGGCAGAATTAAGTGCTGGTGTCTTTCACTGGCAGCATGAAGTTAGCCACCAAGTCCTCACAAGCCGTGCTGCTTAGTTGCTCGGTGGTTATGGA TAAACTTTGCCCAGCATGATTTTTGGGTTCATCTTATCAGTTCCCCTGGTGGGCAGATACACAGTGTTCTGCATTCCACATGTAAGTGAATTGCAAAAAC AAAACAAAACTCACTCTCTTGTAGGTTTATTTATGTGTGTGTGAATGTGTATTTTAATTATGTGTATTTAACTCTTTAAAATCTCTTAGATTTTAATTTA TCCTGTAAATTTCTGTATATATAATTTAATAACAGAAGCCTCCACCAGCAACAGCATGTGGAAGATACAGATTTGTCATTTCTCCCTTCCGCCCTCCCTT CTTTCCTTCCTTCCTTCCCTGTTTCCTTCCCTCTTTCCTTCCTTCCTCCTGGTCTGTTCCAAAAACTCTGAATCATCTACATTTTAAGGTATTTTACCTC AAAAATGAATCATTGTGTTAGGATTCTAATTCTTTATAAAGAACTTCATGGGCTTCAATAATGTCTAGAAAGTAAAATAAAGAGGAATGTTACCATCCCC AGCTGCCCTTATTTCCAGAGAACCAGACGTTTGTTTCCCAGTTGGAAAGAAGACAGTTGAGCACTTCAGGATGGTTTTTAAATTTGGTATGAGATTCTCT GCCAACACCAAGCTCTGAGTTAACTGTGCTTTCTTCTCCTGGCCCTGACAGAGCACTACAGCATCAAAGTAAATCTTTGGGGACAGTGTAGCCCATCTGC ATCCTATTTAATTTCTTCCCTTCTCCCCACCAGTGTTGTCACAGGGCTATGTTGCTTAAAGGTAGTCTGGCTGCTGAATCCCTTTCTCAGCTCAGAGCAG TTTTAAGATTTAATTGGGAATACAGAGAAACAGGATTGTTTGAGAACCAAAATCAAGAGGAACAGAAATCTTAACTTGATTTCATGTGTTAGAACATTGT ACCATGCCTCTTCTGTATCTGTGGAAGTTTCCTGTTTGACACAGGGTATCTAGGAGGGGCGGGGAAGACATGGATAGTATAGGAAGACATTAATCCTAGC ATTGTCATTTATATACATTAATGAAATCCTGATGAGGACCTGCTTTTTGTTTGTTTTCCTTTGAAACCCAGCCCTATTGTATTTGTATTTAAAATTTGTA CACATTTGTATAATAATCTGTACCTTGTGGTATTTGGTACTATTAGAGGAAAAACTTTGGATTCAGACCTTCTTGCAGTTTTTATATCATTGTTTTATTT TGTTTTTTAAATAAATTCTAGTGGTTTGATCCAAATCCCATTACAGTTGTATAAAGAAATAAAATTTTGTACTTATATTATTAAAAATCACATTTTTAAT ATTTGTA

refseq_HMG2L1.F1 (forward primer)
refseq_HMG2L1.R1 (reverse primer)
Single exon skipping

Frame 0

SFSKMAAIGGVEAGSGRAE*RPGPVDGKEPGHS DTFSKALQDHHGL**LREERRLF*W*SYL*GHRT CSWPKPTREKTFLQRFFKGRGRNCCSGQEFFQE EVEG**TLLLGDGHTQEEEEALL**LLLWRTVV LVLSADKPV*RRREVEGWYFGGFSIEEQSAFVIH QIFRLWNRHRRKRKSPAHSLLIQLWTC*KLSLP HWQQAPSPPKRLGRNPLALQAIRRVKRSTTGRK SVEAVGNYP*RMVAPTNRKK*NLSM*TQRH*PFG SLMV*K*NLFCHQRRREAALLMRSLFNIPPNKR L*KNPQRNQLGMSRVLYS*DMSYRAF*KQPGKS TSHPQTHIHLLALKAVGLTPPSSQSPTVLTLIFQ GLNLFW*NQTHPLVGN*RLGS***MILTEKSRR KRSQRRAKRRKTRRSIKRSDTPSPREV*DFLPC QWERSQ*HLALLPASHTLEQQHLPCHFLASTQMG IVKKKRKKKRRTKREREEKSQKRRTCRPTRCSV KSIA*PLWLTIQV*ILGNLVKNWLRCGSNYQKK TN*FGSKKLSICSTNRTKQKPQL*KGKHPAQKVP *KSKPLL*EYCHPRRSPHPPPCCYQPHQPKPLR QSPLMLLLIFSCWESP*ASLDTVCRKLRVWWLC LAVCQCFWIPLSVPLAPWHVSPHNYLN*MAVPNR SCQTH*TTLLTSCRDCDSKESWDRNLILHHCWF VYI*LLQIPSVASGCRF*IFISIHTYIHIYIMY NIYIDCNYFAFNNFMKWQRFSQEEILA*IQAWDS FFSCGG*ICLKNQCNLGAGGLFWVPSASLYGQL KCDYFPSSVGPPDPSLTICLTCLSLKCNRKDNG KMPVD*KFKAFQFEVT*VGGDKICSLYSYGSGLG ELSRGFIPIPTV*VSVSQNLL*SLVPLVASTEA KEFCEPWQQKTPWGVKLSMPPVGPPYILS*PRI FSRQN*VLVSFTGSMKLATKSSQAVLLSCSVVMD KLCPA*FLGSSYQFPWWADTQCSAFHM*VNCKN KTKLTLL*VYLCVCECVF*LCVFNSLKSLRF*F IL*ISVYII**QKPPPATACGRYRFVISPFRPPF FPSFLPCFLPSFLPSSWSVPKTLNHLHFKVFYL KNESLC*DSNSL*RTSWASIMSRK*NKEECYHP QLPLFPENQTFVSQLERRQLSTSGWFLNLV*DSL PTPSSELTVLSSPGPDRALQHQSKSLGTV*PIC ILFNFFPSPHQCCHRAMLLKGSLAAESLSQLRA VLRFNWEYRETGLFENQNQEEQKS*LDFMC*NIV PCLFCICGSFLFDTGYLGGAGKTWIV*EDINPS IVIYIH**NPDEDLLFVCFPLKPSPIVFVFKIC THLYNNLYLVVFGTIRGKTLDSDLLAVFISLFYF VF*INSSGLIQIPLQLYKEIKFCTYIIKNHIFN IC

Frame 1

PSPRWRRSAALRRDPGEPSEDLVL*TGRSLDTV THSQRPCRTTMAYDDSVKKEDCFDGDHTFEDIG LAAGRSQREKKRSYKDFLREEEEIAAQVRNSSKK KLKDSELYFLGTDTHKKKRKHSSDDYYYGGQWF LF*VPINQCEGGERWRAGILEDSA*KNSLHL*Y TRYFVFGIVTEEKEKVQPTVY*YSYGPVESYHFP TGSRLQALQKDWGEILWLFKPFGE*KGAPQEES QWKQWGTTPRGWWLPQIEKNETSLCEHRDTDPS GA*WFKNETYSVTKGEGKQLC**GVFSISLPTSD CEKILKEISSG*AGCFTPRT*VTELSENSPEKA QVILRRTFISWP*RLWV*RLPVRRVPQC*P*SF RA*TYSGRIRLILWWGTRGWGVSDR*FLPRNQEE KEVKEEQKEERQGEA*REATLQVQEKFRTFCRA SGRGHSDIWPSSQHPIRWSSSTSPATSWPPHRW A**KKKEKRREGQRERERRKAKKEEHVGLPGVL* RVSRDHCG*PSRYRFWGT**KTG*GVEAITRKR QTDLEAKSSVSAAQTEQSRSHNCEKESIQLRRF HESQSLFCRSTVTPEEVPTHHHAVTSLTSQSP*D RAH*CCCSSSAVGRVPKPHWTPSAGN*GYGGCV WQFVSASGFHYLCPWPLGMSHHTTT*IEWLSQT GLVKHIRQHCLHHAGTVTAKNPGTETLSYTIAGL CIYDCCRFLQWPLAVGFKFLYLYIHIYIYI*CT IYT*TVTTLLLIIL*NGKGLAKRKFWHEYRLGI LFSPVVDKSALKINVTWGLGACSGCQAHLFMDS* NVIIFQAQLDLQTHH*PFALPVLV*NVIGKITG RCQLTENSKPFNLK*PRWEVIKFVPFIVMEVA* VN*VEGSFQFLLYRCLCLKIYCNHWYHWWPQQRP RSSVSPGSKKHLGG*SCQCHQLDLHTF*ANPES LVGRIKCWCLSLAA*S*PPSPHKPCCLVARWLW INFAQHDFWVHLISSPGGQIHSVLHSTCK*IAKT KQNSLSCRFIYVCVNVYFNYVYLTL*NLLDFNL SCKFLYI*FNNRSLHQQQHVEDTDLSFLPSALP SFLPSFPVSFPLSFLPPGLFQKL*IIYILRYFTS KMNHCVRILILYKELHGLQ*CLESKIKRNVTIP SCPYFQRTRRLFPSWKEDS*ALQDGF*IWYEIL CQHQALS*LCFLLLALTEHYSIKVNLWGQCSPSA SYLISSLLPTSVVTGLCCLKVVWLLNPFLSSEQ F*DLIGNTEKQDCLRTKIKRNRNLNLISCVRTL YHASSVSVEVSCLTQGI*EGRGRHG*YRKTLILA LSFIYINEILMRTCFLFVFL*NPALLYLYLKFV HICIIICTLWYLVLLEEKLWIQTFLQFLYHCFI LFFK*ILVV*SKSHYSCIKK*NFVLILLKITFLI FV

Frame 2

LLQDGGDRRR*GGIRASRVKTWSCRREGAWTQ* HILKGPAGPPWLMMTP*RKKIVLMVIIPLRT*D LQLAEANERKNVLTKIF*GKRKKLLLRSGILPR RS*RIVNFTSWGRTHTRRRGSTPLMITTMEDSGS CSECR*TSVKEERGGGLVFWRIQHRRTVCICDT PDISSLESSQKKKKKSSPQSTDTAMDLLKAITS PLAAGSKPSKKTGEKSSGSSSHSESKKEHHRKKV SGSSGELPLEDGGSHKSKKMKPLYVNTETLTLR EPDGLKMKLILSPKEKGSSSVDEESFQYPSQQA TVKKSSKKSARDEQGALLLGHELQSFLKTARKKH KSSSDAHSSPGPEGCGSDASQFAESHSANLDLS GLEPILVESDSSSGGELEAGELVIDDSYREIKK KKKSKKSKKKKDKEKHKEKRHSKSKRSLGLSAVP VGEVTVTSGPPPSIPYAGAAAPPLPLPGLHTDG HSEKKKKKEEKDKERERGEKPKKKNMSAYQVFC KEYRVTIVADHPGIDFGELSKKLAEVWKQLPEKD KLIWKQKAQYLQHKQNKAEATTVKRKASSSEGS MKVKASSVGVLSPQKKSPPTTMLLPASPAKAPE TEPIDVAAHLQLLGESLSLIGHRLQETEGMVAVS GSLSVLLDSIICALGPLACLTTQLPELNGCPKQ VLSNTLDNIAYIMPGL*QQRILGQKPYPTPLLV CVYMTVADSFSGLWL*VLNFYIYTYIYTYIYNVQ YIHRL*LLCF**FYEMAKV*PRGNFGMNTGLGF FFLLWWINLP*KSM*LGGWGLVLGAKRISLWTA KM*LFSKLSWTSRPITDHLPYLS*SEM**ER*RE DAS*LKIQSLSI*SDLGGR**NLFPL*LWKWLR *IE*RVHSNSYCIGVCVSKFIVIIGTIGGLNRG QGVL*ALAAKNTLGGEAVNATSWTSIHSELTQNL *SAELSAGVFHWQHEVSHQVLTSRAA*LLGGYG *TLPSMIFGFILSVPLVGRYTVFCIPHVSELQK QNKTHSLVGLFMCV*MCILIMCI*LFKIS*ILIY PVNFCIYNLITEASTSNSMWKIQICHFSLPPSL LSFLPSLFPSLFPSFLLVCSKNSESSTF*GILP QK*IIVLGF*FFIKNFMGFNNV*KVK*RGMLPSP AALISREPDVCFPVGKKTVEHFRMVFKFGMRFS ANTKL*VNCAFFSWP*QSTTASK*IFGDSVAHL HPI*FLPFSPPVLSQGYVA*R*SGC*IPFSAQSS FKI*LGIQRNRIV*EPKSRGTEILT*FHVLEHC TMPLLYLWKFPV*HRVSRRGGEDMDSIGRH*S* HCHLYTLMKS**GPAFCLFSFETQPYCICI*NLY TFV**SVPCGIWYY*RKNFGFRPSCSFYIIVLF CFLNKF*WFDPNPITVV*RNKILYLYY*KSHF* YL