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Sequences

Sequence NM_033249

CTCTCCAGAGGCGGGCCCTGAGCCGGCACCTCCCCTTTCGGACAGCTCAAGGGACTCAGCCAACTGGCTCACGCCTCCCCTTCAGCTTCTCTTCACGCAC
TCCAAGATCTAAACCGAGAATCGAAACTAAGCTGGGGTCCATGGAGCCTGCACCCGCCCGATCTCCGAGGCCCCAGCAGGACCCCGCCCGGCCCCAGGAG
CCCACCATGCCTCCCCCCGAGACCCCCTCTGAAGGCCGCCAGCCCAGCCCCAGCCCCAGCCCTACAGAGCGAGCCCCCGCTTCGGAGGAGGAGTTCCAGT
TTCTGCGCTGCCAGCAATGCCAGGCGGAAGCCAAGTGCCCGAAGCTGCTGCCTTGTCTGCACACGCTGTGCTCAGGATGCCTGGAGGCGTCGGGCATGCA
GTGCCCCATCTGCCAGGCGCCCTGGCCCCTAGGTGCAGACACACCCGCCCTGGATAACGTCTTTTTCGAGAGTCTGCAGCGGCGCCTGTCGGTGTACCGG
CAGATTGTGGATGCGCAGGCTGTGTGCACCCGCTGCAAAGAGTCGGCCGACTTCTGGTGCTTTGAGTGCGAGCAGCTCCTCTGCGCCAAGTGCTTCGAGG
CACACCAGTGGTTCCTCAAGCACGAGGCCCGGCCCCTAGCAGAGCTGCGCAACCAGTCGGTGCGTGAGTTCCTGGACGGCACCCGCAAGACCAACAACAT
CTTCTGCTCCAACCCCAACCACCGCACCCCTACGCTGACCAGCATCTACTGCCGAGGATGTTCCAAGCCGCTGTGCTGCTCGTGCGCGCTCCTTGACAGC
AGCCACAGTGAGCTCAAGTGCGACATCAGCGCAGAGATCCAGCAGCGACAGGAGGAGCTGGACGCCATGACGCAGGCGCTGCAGGAGCAGGATAGTGCCT
TTGGCGCGGTTCACGCGCAGATGCACGCGGCCGTCGGCCAGCTGGGCCGCGCGCGTGCCGAGACCGAGGAGCTGATCCGCGAGCGCGTGCGCCAGGTGGT
AGCTCACGTGCGGGCTCAGGAGCGCGAGCTGCTGGAGGCTGTGGACGCGCGGTACCAGCGCGACTACGAGGAGATGGCCAGTCGGCTGGGCCGCCTGGAT
GCTGTGCTGCAGCGCATCCGCACGGGCAGCGCGCTGGTGCAGAGGATGAAGTGCTACGCCTCGGACCAGGAGGTGCTGGACATGCACGGTTTCCTGCGCC
AGGCGCTCTGCCGCCTGCGCCAGGAGGAGCCCCAGAGCCTGCAAGCTGCCGTGCGCACCGATGGCTTCGACGAGTTCAAGGTGCGCCTGCAGGACCTCAG
CTCTTGCATCACCCAGGGGAAAGATGCAGCTGTATCCAAGAAAGCCAGCCCAGAGGCTGCCAGCACTCCCAGGGACCCTATTGACGTTGACCTGGATGTC
TCCAATACAACGACAGCCCAGAAGAGGAAGTGCAGCCAGACCCAGTGCCCCAGGAAGGTCATCAAGATGGAGTCTGAGGAGGGGAAGGAGGCAAGGTTGG
CTCGGAGCTCCCCGGAGCAGCCCAGGCCCAGCACCTCCAAGGCAGTCTCACCACCCCACCTGGATGGACCGCCTAGCCCCAGGAGCCCCGTCATAGGAAG
TGAGGTCTTCCTGCCCAACAGCAACCACGTGGCCAGTGGCGCCGGGGAGGCAGAGGAACGCGTTGTGGTGATCAGCAGCTCGGAAGACTCAGATGCCGAA
AACTCGTCCTCCCGAGAGCTGGATGACAGCAGCAGTGAGTCCAGTGACCTCCAGCTGGAAGGCCCCAGCACCCTCAGGGTCCTGGACGAGAACCTTGCTG
ACCCCCAAGCAGAAGACAGACCTCTGGTTTTCTTTGACCTCAAGATTGACAATGAAAGTGGGTTCTCCTGGGGCTACCCCCACCCCTTTCTAATTTAGTC
TCTGAGTCCCAAAAAGAAGTGCAGGCAGAGCCATCTGCCAGGCCCAGGAGAGCTCTGAGCTCTGGCCAACAACTGCAGCCAGGCTGGGCAGAGCACTCCG
GCTCACCTGGGCTCCTGGCGTGTCATTTGCTGGCTTGAATAAAGATGTCCGCCTTATCCAGTGCCTGAGTGTGCGAGAGAGGCAGATGCCTCCA
  • refseq_PML.F2 (forward primer)
  • refseq_PML.R2 (reverse primer)
  • Single exon skipping

Frame 0

LSRGGP*AGTSPFGQLKGLSQLAHASPSASLHA
LQDLNRESKLSWGPWSLHPPDLRGPSRTPPGPRS
PPCLPPRPPLKAASPAPAPALQSEPPLRRRSSS
FCAASNARRKPSARSCCLVCTRCAQDAWRRRAC
SAPSARRPGP*VQTHPPWITSFSRVCSGACRCTG
RLWMRRLCAPAAKSRPTSGALSASSSSAPSASR
HTSGSSSTRPGP*QSCATSRCVSSWTAPARPTT
SSAPTPTTAPLR*PASTAEDVPSRCAARARSLTA
ATVSSSATSAQRSSSDRRSWTP*RRRCRSRIVP
LARFTRRCTRPSASWAARVPRPRS*SASACARW
*LTCGLRSASCWRLWTRGTSATTRRWPVGWAAWM
LCCSASARAARWCRG*SATPRTRRCWTCTVSCA
RRSAACARRSPRACKLPCAPMASTSSRCACRTS
ALASPRGKMQLYPRKPAQRLPALPGTLLTLTWMS
PIQRQPRRGSAARPSAPGRSSRWSLRRGRRQGW
LGAPRSSPGPAPPRQSHHPTWMDRLAPGAPS*E
VRSSCPTATTWPVAPGRQRNALW*SAARKTQMPK
TRPPESWMTAAVSPVTSSWKAPAPSGSWTRTLL
TPKQKTDLWFSLTSRLTMKVGSPGATPTPF*FS
L*VPKRSAGRAICQAQESSELWPTTAARLGRALR
LTWAPGVSFAGLNKDVRLIQCLSVRERQMPP

Frame 1

SPEAGPEPAPPLSDSSRDSANWLTPPLQLLFTH
SKI*TENRN*AGVHGACTRPISEAPAGPRPAPG
AHHASPRDPL*RPPAQPQPQPYRASPRFGGGVPV
SALPAMPGGSQVPEAAALSAHAVLRMPGGVGHA
VPHLPGALAPRCRHTRPG*RLFRESAAAPVGVP
ADCGCAGCVHPLQRVGRLLVL*VRAAPLRQVLRG
TPVVPQARGPAPSRAAQPVGA*VPGRHPQDQQH
LLLQPQPPHPYADQHLLPRMFQAAVLLVRAP*Q
QPQ*AQVRHQRRDPAATGGAGRHDAGAAGAG*CL
WRGSRADARGRRPAGPRACRDRGADPRARAPGG
SSRAGSGARAAGGCGRAVPARLRGDGQSAGPPG
CCAAAHPHGQRAGAEDEVLRLGPGGAGHARFPAP
GALPPAPGGAPEPASCRAHRWLRRVQGAPAGPQ
LLHHPGERCSCIQESQPRGCQHSQGPY*R*PGC
LQYNDSPEEEVQPDPVPQEGHQDGV*GGEGGKVG
SELPGAAQAQHLQGSLTTPPGWTA*PQEPRHRK
*GLPAQQQPRGQWRRGGRGTRCGDQQLGRLRCR
KLVLPRAG*QQQ*VQ*PPAGRPQHPQGPGREPC*
PPSRRQTSGFL*PQD*Q*KWVLLGLPPPLSNLV
SESQKEVQAEPSARPRRALSSGQQLQPGWAEHS
GSPGLLACHLLA*IKMSALSSA*VCERGRCL

Frame 2

LQRRALSRHLPFRTAQGTQPTGSRLPFSFSSRT
PRSKPRIETKLGSMEPAPARSPRPQQDPARPQE
PTMPPPETPSEGRQPSPSPSPTERAPASEEEFQ
FLRCQQCQAEAKCPKLLPCLHTLCSGCLEASGMQ
CPICQAPWPLGADTPALDNVFFESLQRRLSVYR
QIVDAQAVCTRCKESADFWCFECEQLLCAKCFE
AHQWFLKHEARPLAELRNQSVREFLDGTRKTNNI
FCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDS
SHSELKCDISAEIQQRQEELDAMTQALQEQDSA
FGAVHAQMHAAVGQLGRARAETEELIRERVRQVV
AHVRAQERELLEAVDARYQRDYEEMASRLGRLD
AVLQRIRTGSALVQRMKCYASDQEVLDMHGFLR
QALCRLRQEEPQSLQAAVRTDGFDEFKVRLQDLS
SCITQGKDAAVSKKASPEAASTPRDPIDVDLDV
SNTTTAQKRKCSQTQCPRKVIKMESEEGKEARL
ARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGS
EVFLPNSNHVASGAGEAEERVVVISSSEDSDAE
NSSSRELDDSSSESSDLQLEGPSTLRVLDENLA
DPQAEDRPLVFFDLKIDNESGFSWGYPHPFLI*S
LSPKKKCRQSHLPGPGEL*ALANNCSQAGQSTP
AHLGSWRVICWLE*RCPPYPVPECAREADAS

Sequence NM_033250

CTCTCCAGAGGCGGGCCCTGAGCCGGCACCTCCCCTTTCGGACAGCTCAAGGGACTCAGCCAACTGGCTCACGCCTCCCCTTCAGCTTCTCTTCACGCAC
TCCAAGATCTAAACCGAGAATCGAAACTAAGCTGGGGTCCATGGAGCCTGCACCCGCCCGATCTCCGAGGCCCCAGCAGGACCCCGCCCGGCCCCAGGAG
CCCACCATGCCTCCCCCCGAGACCCCCTCTGAAGGCCGCCAGCCCAGCCCCAGCCCCAGCCCTACAGAGCGAGCCCCCGCTTCGGAGGAGGAGTTCCAGT
TTCTGCGCTGCCAGCAATGCCAGGCGGAAGCCAAGTGCCCGAAGCTGCTGCCTTGTCTGCACACGCTGTGCTCAGGATGCCTGGAGGCGTCGGGCATGCA
GTGCCCCATCTGCCAGGCGCCCTGGCCCCTAGGTGCAGACACACCCGCCCTGGATAACGTCTTTTTCGAGAGTCTGCAGCGGCGCCTGTCGGTGTACCGG
CAGATTGTGGATGCGCAGGCTGTGTGCACCCGCTGCAAAGAGTCGGCCGACTTCTGGTGCTTTGAGTGCGAGCAGCTCCTCTGCGCCAAGTGCTTCGAGG
CACACCAGTGGTTCCTCAAGCACGAGGCCCGGCCCCTAGCAGAGCTGCGCAACCAGTCGGTGCGTGAGTTCCTGGACGGCACCCGCAAGACCAACAACAT
CTTCTGCTCCAACCCCAACCACCGCACCCCTACGCTGACCAGCATCTACTGCCGAGGATGTTCCAAGCCGCTGTGCTGCTCGTGCGCGCTCCTTGACAGC
AGCCACAGTGAGCTCAAGTGCGACATCAGCGCAGAGATCCAGCAGCGACAGGAGGAGCTGGACGCCATGACGCAGGCGCTGCAGGAGCAGGATAGTGCCT
TTGGCGCGGTTCACGCGCAGATGCACGCGGCCGTCGGCCAGCTGGGCCGCGCGCGTGCCGAGACCGAGGAGCTGATCCGCGAGCGCGTGCGCCAGGTGGT
AGCTCACGTGCGGGCTCAGGAGCGCGAGCTGCTGGAGGCTGTGGACGCGCGGTACCAGCGCGACTACGAGGAGATGGCCAGTCGGCTGGGCCGCCTGGAT
GCTGTGCTGCAGCGCATCCGCACGGGCAGCGCGCTGGTGCAGAGGATGAAGTGCTACGCCTCGGACCAGGAGGTGCTGGACATGCACGGTTTCCTGCGCC
AGGCGCTCTGCCGCCTGCGCCAGGAGGAGCCCCAGAGCCTGCAAGCTGCCGTGCGCACCGATGGCTTCGACGAGTTCAAGGTGCGCCTGCAGGACCTCAG
CTCTTGCATCACCCAGGGGAAAGATGCAGCTGTATCCAAGAAAGCCAGCCCAGAGGCTGCCAGCACTCCCAGGGACCCTATTGACGTTGACCTGGATGTC
TCCAATACAACGACAGCCCAGAAGAGGAAGTGCAGCCAGACCCAGTGCCCCAGGAAGGTCATCAAGATGGAGTCTGAGGAGGGGAAGGAGGCAAGGTTGG
CTCGGAGCTCCCCGGAGCAGCCCAGGCCCAGCACCTCCAAGGCAGTCTCACCACCCCACCTGGATGGACCGCCTAGCCCCAGGAGCCCCGTCATAGGAAG
TGAGGTCTTCCTGCCCAACAGCAACCACGTGGCCAGTGGCGCCGGGGAGGCAGAGGAACGCGTTGTGGTGATCAGCAGCTCGGAAGACTCAGATGCCGAA
AACTCGTGCATGGAGCCCATGGAGACCGCCGAGCCACAGTCCTCGCCAGCCCACTCCTCGCCAGCCCACTCCTCGCCAGCCCACTCCTCGCCAGTCCAGT
CTCTGCTGAGAGCACAAGGAGCCTCCAGCCTGCCCTGTGGCACATACCACCCCCCAGCTTGGCCTCCCCACCAGCCCGCTGAGCAGGCTGCCACCCCCGA
TGCTGAGCCTCACAGCGAGCCTCCTGATCACCAGGAGCGCCCTGCCGTCCACCGTGGGATCCGCTACCTGTTGTACAGAGCACAGAGAGCCATCCGCCTT
CGCCATGCCCTCCGCTTGCACCCTCAATTGCATCGGGCCCCTATTCGGACTTGGTCTCCCCATGTGGTCCAAGCCAGCACTCCTGCCATCACAGGGCCCC
TCAACCATCCTGCCAATGCCCAGGAACATCCTGCCCAGCTGCAAAGGGGCATCAGCCCACCCCACCGGATACGAGGGGCTGTGCGATCCCGCAGCCGCTC
CCTCCGGGGCTCCTCCCATTTATCCCAGTGGCTCAACAACTTTTTTGCCCTCCCCTTCTCCTCCATGGCTTCCCAGCTTGACATGTCTTCCGTGGTGGGG
GCAGGGGAAAGCAGAGCCCAGACTCTTGGAGCAGGTGTTCCCCCTGGGGACTCTGTCAGAGGCTCCATGGAGGCCTCTCAAGTCCAAGTGCCTCTGGAAG
CCTCTCCAATTACATTCCCACCACCCTGTGCCCCAGAAAGGCCCCCCATCAGCCCAGTCCCAGGCGCCCGTCAAGCAGGCCTCTGAGAGTGCTACCCTTC
TCTTGTAACCTTGCAGCCAACACCCCTGCCCGGCCCCTGAGCTGCCTCCTCCAGCCCATGCTCTTACAGGCCCTGCACAGAGTAGCACTCATTAATTCTT
GGTTAAGGAATGAATCAACGAATGAATGGCTATGCATGGACCTCTGGGCAGGGAGACCTGGGTCTTCTCTGGCTGAGAGGGGAAGGCTAAGGCATGGCTG
AGATTCAAGCCACCATTCCAGGCCTCTTTGCCCAAGAAAGAAACTTCTGTCACCCTTGCACTCTCCTGTATTCTGAGTCCCTGGCCAATAGCACAGCCTT
CCATGCCCCGACCCCCACCCCAAGCCTCTCCACTAGGCCTCTGCCAGGATCTAAGCCCATGAGCACAGGGACTGGCTATCCCAAGACCTGGCAGATGTGG
CTGCTCAATAAACACTTGTTGAACCATCA
  • refseq_PML.F2 (forward primer)
  • refseq_PML.R2 (reverse primer)
  • Single exon skipping

Frame 0

LSRGGP*AGTSPFGQLKGLSQLAHASPSASLHA
LQDLNRESKLSWGPWSLHPPDLRGPSRTPPGPRS
PPCLPPRPPLKAASPAPAPALQSEPPLRRRSSS
FCAASNARRKPSARSCCLVCTRCAQDAWRRRAC
SAPSARRPGP*VQTHPPWITSFSRVCSGACRCTG
RLWMRRLCAPAAKSRPTSGALSASSSSAPSASR
HTSGSSSTRPGP*QSCATSRCVSSWTAPARPTT
SSAPTPTTAPLR*PASTAEDVPSRCAARARSLTA
ATVSSSATSAQRSSSDRRSWTP*RRRCRSRIVP
LARFTRRCTRPSASWAARVPRPRS*SASACARW
*LTCGLRSASCWRLWTRGTSATTRRWPVGWAAWM
LCCSASARAARWCRG*SATPRTRRCWTCTVSCA
RRSAACARRSPRACKLPCAPMASTSSRCACRTS
ALASPRGKMQLYPRKPAQRLPALPGTLLTLTWMS
PIQRQPRRGSAARPSAPGRSSRWSLRRGRRQGW
LGAPRSSPGPAPPRQSHHPTWMDRLAPGAPS*E
VRSSCPTATTWPVAPGRQRNALW*SAARKTQMPK
TRAWSPWRPPSHSPRQPTPRQPTPRQPTPRQSS
LC*EHKEPPACPVAHTTPQLGLPTSPLSRLPPP
MLSLTASLLITRSALPSTVGSATCCTEHREPSAF
AMPSACTLNCIGPLFGLGLPMWSKPALLPSQGP
STILPMPRNILPSCKGASAHPTGYEGLCDPAAA
PSGAPPIYPSGSTTFLPSPSPPWLPSLTCLPWWG
QGKAEPRLLEQVFPLGTLSEAPWRPLKSKCLWK
PLQLHSHHPVPQKGPPSAQSQAPVKQASESATL
LL*PCSQHPCPAPELPPPAHALTGPAQSSTH*FL
VKE*INE*MAMHGPLGRETWVFSG*EGKAKAWL
RFKPPFQASLPKKETSVTLALSCILSPWPIAQP
SMPRPPPQASPLGLCQDLSP*AQGLAIPRPGRCG
CSINTC*TI

Frame 1

SPEAGPEPAPPLSDSSRDSANWLTPPLQLLFTH
SKI*TENRN*AGVHGACTRPISEAPAGPRPAPG
AHHASPRDPL*RPPAQPQPQPYRASPRFGGGVPV
SALPAMPGGSQVPEAAALSAHAVLRMPGGVGHA
VPHLPGALAPRCRHTRPG*RLFRESAAAPVGVP
ADCGCAGCVHPLQRVGRLLVL*VRAAPLRQVLRG
TPVVPQARGPAPSRAAQPVGA*VPGRHPQDQQH
LLLQPQPPHPYADQHLLPRMFQAAVLLVRAP*Q
QPQ*AQVRHQRRDPAATGGAGRHDAGAAGAG*CL
WRGSRADARGRRPAGPRACRDRGADPRARAPGG
SSRAGSGARAAGGCGRAVPARLRGDGQSAGPPG
CCAAAHPHGQRAGAEDEVLRLGPGGAGHARFPAP
GALPPAPGGAPEPASCRAHRWLRRVQGAPAGPQ
LLHHPGERCSCIQESQPRGCQHSQGPY*R*PGC
LQYNDSPEEEVQPDPVPQEGHQDGV*GGEGGKVG
SELPGAAQAQHLQGSLTTPPGWTA*PQEPRHRK
*GLPAQQQPRGQWRRGGRGTRCGDQQLGRLRCR
KLVHGAHGDRRATVLASPLLASPLLASPLLASPV
SAESTRSLQPALWHIPPPSLASPPAR*AGCHPR
C*ASQRAS*SPGAPCRPPWDPLPVVQSTESHPP
SPCPPLAPSIASGPYSDLVSPCGPSQHSCHHRAP
QPSCQCPGTSCPAAKGHQPTPPDTRGCAIPQPL
PPGLLPFIPVAQQLFCPPLLLHGFPA*HVFRGG
GRGKQSPDSWSRCSPWGLCQRLHGGLSSPSASGS
LSNYIPTTLCPRKAPHQPSPRRPSSRPLRVLPF
SCNLAANTPARPLSCLLQPMLLQALHRVALINS
WLRNESTNEWLCMDLWAGRPGSSLAERGRLRHG*
DSSHHSRPLCPRKKLLSPLHSPVF*VPGQ*HSL
PCPDPHPKPLH*ASARI*AHEHRDWLSQDLADV
AAQ*TLVEPS

Frame 2

LQRRALSRHLPFRTAQGTQPTGSRLPFSFSSRT
PRSKPRIETKLGSMEPAPARSPRPQQDPARPQE
PTMPPPETPSEGRQPSPSPSPTERAPASEEEFQ
FLRCQQCQAEAKCPKLLPCLHTLCSGCLEASGMQ
CPICQAPWPLGADTPALDNVFFESLQRRLSVYR
QIVDAQAVCTRCKESADFWCFECEQLLCAKCFE
AHQWFLKHEARPLAELRNQSVREFLDGTRKTNNI
FCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDS
SHSELKCDISAEIQQRQEELDAMTQALQEQDSA
FGAVHAQMHAAVGQLGRARAETEELIRERVRQVV
AHVRAQERELLEAVDARYQRDYEEMASRLGRLD
AVLQRIRTGSALVQRMKCYASDQEVLDMHGFLR
QALCRLRQEEPQSLQAAVRTDGFDEFKVRLQDLS
SCITQGKDAAVSKKASPEAASTPRDPIDVDLDV
SNTTTAQKRKCSQTQCPRKVIKMESEEGKEARL
ARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGS
EVFLPNSNHVASGAGEAEERVVVISSSEDSDAE
NSCMEPMETAEPQSSPAHSSPAHSSPAHSSPVQ
SLLRAQGASSLPCGTYHPPAWPPHQPAEQAATPD
AEPHSEPPDHQERPAVHRGIRYLLYRAQRAIRL
RHALRLHPQLHRAPIRTWSPHVVQASTPAITGP
LNHPANAQEHPAQLQRGISPPHRIRGAVRSRSRS
LRGSSHLSQWLNNFFALPFSSMASQLDMSSVVG
AGESRAQTLGAGVPPGDSVRGSMEASQVQVPLE
ASPITFPPPCAPERPPISPVPGARQAGL*ECYPS
LVTLQPTPLPGP*AASSSPCSYRPCTE*HSLIL
G*GMNQRMNGYAWTSGQGDLGLLWLRGEG*GMA
EIQATIPGLFAQERNFCHPCTLLYSESLANSTAF
HAPTPTPSLSTRPLPGSKPMSTGTGYPKTWQMW
LLNKHLLNH

Sequence NM_033239

CTCTCCAGAGGCGGGCCCTGAGCCGGCACCTCCCCTTTCGGACAGCTCAAGGGACTCAGCCAACTGGCTCACGCCTCCCCTTCAGCTTCTCTTCACGCAC
TCCAAGATCTAAACCGAGAATCGAAACTAAGCTGGGGTCCATGGAGCCTGCACCCGCCCGATCTCCGAGGCCCCAGCAGGACCCCGCCCGGCCCCAGGAG
CCCACCATGCCTCCCCCCGAGACCCCCTCTGAAGGCCGCCAGCCCAGCCCCAGCCCCAGCCCTACAGAGCGAGCCCCCGCTTCGGAGGAGGAGTTCCAGT
TTCTGCGCTGCCAGCAATGCCAGGCGGAAGCCAAGTGCCCGAAGCTGCTGCCTTGTCTGCACACGCTGTGCTCAGGATGCCTGGAGGCGTCGGGCATGCA
GTGCCCCATCTGCCAGGCGCCCTGGCCCCTAGGTGCAGACACACCCGCCCTGGATAACGTCTTTTTCGAGAGTCTGCAGCGGCGCCTGTCGGTGTACCGG
CAGATTGTGGATGCGCAGGCTGTGTGCACCCGCTGCAAAGAGTCGGCCGACTTCTGGTGCTTTGAGTGCGAGCAGCTCCTCTGCGCCAAGTGCTTCGAGG
CACACCAGTGGTTCCTCAAGCACGAGGCCCGGCCCCTAGCAGAGCTGCGCAACCAGTCGGTGCGTGAGTTCCTGGACGGCACCCGCAAGACCAACAACAT
CTTCTGCTCCAACCCCAACCACCGCACCCCTACGCTGACCAGCATCTACTGCCGAGGATGTTCCAAGCCGCTGTGCTGCTCGTGCGCGCTCCTTGACAGC
AGCCACAGTGAGCTCAAGTGCGACATCAGCGCAGAGATCCAGCAGCGACAGGAGGAGCTGGACGCCATGACGCAGGCGCTGCAGGAGCAGGATAGTGCCT
TTGGCGCGGTTCACGCGCAGATGCACGCGGCCGTCGGCCAGCTGGGCCGCGCGCGTGCCGAGACCGAGGAGCTGATCCGCGAGCGCGTGCGCCAGGTGGT
AGCTCACGTGCGGGCTCAGGAGCGCGAGCTGCTGGAGGCTGTGGACGCGCGGTACCAGCGCGACTACGAGGAGATGGCCAGTCGGCTGGGCCGCCTGGAT
GCTGTGCTGCAGCGCATCCGCACGGGCAGCGCGCTGGTGCAGAGGATGAAGTGCTACGCCTCGGACCAGGAGGTGCTGGACATGCACGGTTTCCTGCGCC
AGGCGCTCTGCCGCCTGCGCCAGGAGGAGCCCCAGAGCCTGCAAGCTGCCGTGCGCACCGATGGCTTCGACGAGTTCAAGGTGCGCCTGCAGGACCTCAG
CTCTTGCATCACCCAGGGGAAAGATGCAGCTGTATCCAAGAAAGCCAGCCCAGAGGCTGCCAGCACTCCCAGGGACCCTATTGACGTTGACCTGCCCGAG
GAGGCAGAGAGAGTGAAGGCCCAGGTTCAGGCCCTGGGGCTGGCTGAAGCCCAGCCTATGGCTGTGGTACAGTCAGTGCCCGGGGCACACCCCGTGCCAG
TGTACGCCTTCTCCATCAAAGGCCCTTCCTATGGAGAGGATGTCTCCAATACAACGACAGCCCAGAAGAGGAAGTGCAGCCAGACCCAGTGCCCCAGGAA
GGTCATCAAGATGGAGTCTGAGGAGGGGAAGGAGGCAAGGTTGGCTCGGAGCTCCCCGGAGCAGCCCAGGCCCAGCACCTCCAAGGCAGTCTCACCACCC
CACCTGGATGGACCGCCTAGCCCCAGGAGCCCCGTCATAGGAAGTGAGGTCTTCCTGCCCAACAGCAACCACGTGGCCAGTGGCGCCGGGGAGGCAGAGG
AACGCGTTGTGGTGATCAGCAGCTCGGAAGACTCAGATGCCGAAAACTCGTGCATGGAGCCCATGGAGACCGCCGAGCCACAGTCCTCGCCAGCCCACTC
CTCGCCAGCCCACTCCTCGCCAGCCCACTCCTCGCCAGTCCAGTCTCTGCTGAGAGCACAAGGAGCCTCCAGCCTGCCCTGTGGCACATACCACCCCCCA
GCTTGGCCTCCCCACCAGCCCGCTGAGCAGGCTGCCACCCCCGATGCTGAGCCTCACAGCGAGCCTCCTGATCACCAGGAGCGCCCTGCCGTCCACCGTG
GGATCCGCTACCTGTTGTACAGAGCACAGAGAGCCATCCGCCTTCGCCATGCCCTCCGCTTGCACCCTCAATTGCATCGGGCCCCTATTCGGACTTGGTC
TCCCCATGTGGTCCAAGCCAGCACTCCTGCCATCACAGGGCCCCTCAACCATCCTGCCAATGCCCAGGAACATCCTGCCCAGCTGCAAAGGGGCATCAGC
CCACCCCACCGGATACGAGGGGCTGTGCGATCCCGCAGCCGCTCCCTCCGGGGCTCCTCCCATTTATCCCAGTGGCTCAACAACTTTTTTGCCCTCCCCT
TCTCCTCCATGGCTTCCCAGCTTGACATGTCTTCCGTGGTGGGGGCAGGGGAAAGCAGAGCCCAGACTCTTGGAGCAGGTGTTCCCCCTGGGGACTCTGT
CAGAGGCTCCATGGAGGCCTCTCAAGTCCAAGTGCCTCTGGAAGCCTCTCCAATTACATTCCCACCACCCTGTGCCCCAGAAAGGCCCCCCATCAGCCCA
GTCCCAGGCGCCCGTCAAGCAGGCCTCTGAGAGTGCTACCCTTCTCTTGTAACCTTGCAGCCAACACCCCTGCCCGGCCCCTGAGCTGCCTCCTCCAGCC
CATGCTCTTACAGGCCCTGCACAGAGTAGCACTCATTAATTCTTGGTTAAGGAATGAATCAACGAATGAATGGCTATGCATGGACCTCTGGGCAGGGAGA
CCTGGGTCTTCTCTGGCTGAGAGGGGAAGGCTAAGGCATGGCTGAGATTCAAGCCACCATTCCAGGCCTCTTTGCCCAAGAAAGAAACTTCTGTCACCCT
TGCACTCTCCTGTATTCTGAGTCCCTGGCCAATAGCACAGCCTTCCATGCCCCGACCCCCACCCCAAGCCTCTCCACTAGGCCTCTGCCAGGATCTAAGC
CCATGAGCACAGGGACTGGCTATCCCAAGACCTGGCAGATGTGGCTGCTCAATAAACACTTGTTGAACCATCA
  • refseq_PML.F2 (forward primer)
  • refseq_PML.R2 (reverse primer)
  • Single exon skipping

Frame 0

LSRGGP*AGTSPFGQLKGLSQLAHASPSASLHA
LQDLNRESKLSWGPWSLHPPDLRGPSRTPPGPRS
PPCLPPRPPLKAASPAPAPALQSEPPLRRRSSS
FCAASNARRKPSARSCCLVCTRCAQDAWRRRAC
SAPSARRPGP*VQTHPPWITSFSRVCSGACRCTG
RLWMRRLCAPAAKSRPTSGALSASSSSAPSASR
HTSGSSSTRPGP*QSCATSRCVSSWTAPARPTT
SSAPTPTTAPLR*PASTAEDVPSRCAARARSLTA
ATVSSSATSAQRSSSDRRSWTP*RRRCRSRIVP
LARFTRRCTRPSASWAARVPRPRS*SASACARW
*LTCGLRSASCWRLWTRGTSATTRRWPVGWAAWM
LCCSASARAARWCRG*SATPRTRRCWTCTVSCA
RRSAACARRSPRACKLPCAPMASTSSRCACRTS
ALASPRGKMQLYPRKPAQRLPALPGTLLTLTCPR
RQRE*RPRFRPWGWLKPSLWLWYSQCPGHTPCQ
CTPSPSKALPMERMSPIQRQPRRGSAARPSAPG
RSSRWSLRRGRRQGWLGAPRSSPGPAPPRQSHHP
TWMDRLAPGAPS*EVRSSCPTATTWPVAPGRQR
NALW*SAARKTQMPKTRAWSPWRPPSHSPRQPT
PRQPTPRQPTPRQSSLC*EHKEPPACPVAHTTPQ
LGLPTSPLSRLPPPMLSLTASLLITRSALPSTV
GSATCCTEHREPSAFAMPSACTLNCIGPLFGLG
LPMWSKPALLPSQGPSTILPMPRNILPSCKGASA
HPTGYEGLCDPAAAPSGAPPIYPSGSTTFLPSP
SPPWLPSLTCLPWWGQGKAEPRLLEQVFPLGTL
SEAPWRPLKSKCLWKPLQLHSHHPVPQKGPPSAQ
SQAPVKQASESATLLL*PCSQHPCPAPELPPPA
HALTGPAQSSTH*FLVKE*INE*MAMHGPLGRE
TWVFSG*EGKAKAWLRFKPPFQASLPKKETSVTL
ALSCILSPWPIAQPSMPRPPPQASPLGLCQDLS
P*AQGLAIPRPGRCGCSINTC*TI

Frame 1

SPEAGPEPAPPLSDSSRDSANWLTPPLQLLFTH
SKI*TENRN*AGVHGACTRPISEAPAGPRPAPG
AHHASPRDPL*RPPAQPQPQPYRASPRFGGGVPV
SALPAMPGGSQVPEAAALSAHAVLRMPGGVGHA
VPHLPGALAPRCRHTRPG*RLFRESAAAPVGVP
ADCGCAGCVHPLQRVGRLLVL*VRAAPLRQVLRG
TPVVPQARGPAPSRAAQPVGA*VPGRHPQDQQH
LLLQPQPPHPYADQHLLPRMFQAAVLLVRAP*Q
QPQ*AQVRHQRRDPAATGGAGRHDAGAAGAG*CL
WRGSRADARGRRPAGPRACRDRGADPRARAPGG
SSRAGSGARAAGGCGRAVPARLRGDGQSAGPPG
CCAAAHPHGQRAGAEDEVLRLGPGGAGHARFPAP
GALPPAPGGAPEPASCRAHRWLRRVQGAPAGPQ
LLHHPGERCSCIQESQPRGCQHSQGPY*R*PAR
GGRESEGPGSGPGAG*SPAYGCGTVSARGTPRAS
VRLLHQRPFLWRGCLQYNDSPEEEVQPDPVPQE
GHQDGV*GGEGGKVGSELPGAAQAQHLQGSLTT
PPGWTA*PQEPRHRK*GLPAQQQPRGQWRRGGRG
TRCGDQQLGRLRCRKLVHGAHGDRRATVLASPL
LASPLLASPLLASPVSAESTRSLQPALWHIPPP
SLASPPAR*AGCHPRC*ASQRAS*SPGAPCRPPW
DPLPVVQSTESHPPSPCPPLAPSIASGPYSDLV
SPCGPSQHSCHHRAPQPSCQCPGTSCPAAKGHQ
PTPPDTRGCAIPQPLPPGLLPFIPVAQQLFCPPL
LLHGFPA*HVFRGGGRGKQSPDSWSRCSPWGLC
QRLHGGLSSPSASGSLSNYIPTTLCPRKAPHQP
SPRRPSSRPLRVLPFSCNLAANTPARPLSCLLQP
MLLQALHRVALINSWLRNESTNEWLCMDLWAGR
PGSSLAERGRLRHG*DSSHHSRPLCPRKKLLSP
LHSPVF*VPGQ*HSLPCPDPHPKPLH*ASARI*A
HEHRDWLSQDLADVAAQ*TLVEPS

Frame 2

LQRRALSRHLPFRTAQGTQPTGSRLPFSFSSRT
PRSKPRIETKLGSMEPAPARSPRPQQDPARPQE
PTMPPPETPSEGRQPSPSPSPTERAPASEEEFQ
FLRCQQCQAEAKCPKLLPCLHTLCSGCLEASGMQ
CPICQAPWPLGADTPALDNVFFESLQRRLSVYR
QIVDAQAVCTRCKESADFWCFECEQLLCAKCFE
AHQWFLKHEARPLAELRNQSVREFLDGTRKTNNI
FCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDS
SHSELKCDISAEIQQRQEELDAMTQALQEQDSA
FGAVHAQMHAAVGQLGRARAETEELIRERVRQVV
AHVRAQERELLEAVDARYQRDYEEMASRLGRLD
AVLQRIRTGSALVQRMKCYASDQEVLDMHGFLR
QALCRLRQEEPQSLQAAVRTDGFDEFKVRLQDLS
SCITQGKDAAVSKKASPEAASTPRDPIDVDLPE
EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVP
VYAFSIKGPSYGEDVSNTTTAQKRKCSQTQCPRK
VIKMESEEGKEARLARSSPEQPRPSTSKAVSPP
HLDGPPSPRSPVIGSEVFLPNSNHVASGAGEAE
ERVVVISSSEDSDAENSCMEPMETAEPQSSPAHS
SPAHSSPAHSSPVQSLLRAQGASSLPCGTYHPP
AWPPHQPAEQAATPDAEPHSEPPDHQERPAVHR
GIRYLLYRAQRAIRLRHALRLHPQLHRAPIRTWS
PHVVQASTPAITGPLNHPANAQEHPAQLQRGIS
PPHRIRGAVRSRSRSLRGSSHLSQWLNNFFALP
FSSMASQLDMSSVVGAGESRAQTLGAGVPPGDSV
RGSMEASQVQVPLEASPITFPPPCAPERPPISP
VPGARQAGL*ECYPSLVTLQPTPLPGP*AASSS
PCSYRPCTE*HSLILG*GMNQRMNGYAWTSGQGD
LGLLWLRGEG*GMAEIQATIPGLFAQERNFCHP
CTLLYSESLANSTAFHAPTPTPSLSTRPLPGSK
PMSTGTGYPKTWQMWLLNKHLLNH

Sequence NM_033240

CTCTCCAGAGGCGGGCCCTGAGCCGGCACCTCCCCTTTCGGACAGCTCAAGGGACTCAGCCAACTGGCTCACGCCTCCCCTTCAGCTTCTCTTCACGCAC
TCCAAGATCTAAACCGAGAATCGAAACTAAGCTGGGGTCCATGGAGCCTGCACCCGCCCGATCTCCGAGGCCCCAGCAGGACCCCGCCCGGCCCCAGGAG
CCCACCATGCCTCCCCCCGAGACCCCCTCTGAAGGCCGCCAGCCCAGCCCCAGCCCCAGCCCTACAGAGCGAGCCCCCGCTTCGGAGGAGGAGTTCCAGT
TTCTGCGCTGCCAGCAATGCCAGGCGGAAGCCAAGTGCCCGAAGCTGCTGCCTTGTCTGCACACGCTGTGCTCAGGATGCCTGGAGGCGTCGGGCATGCA
GTGCCCCATCTGCCAGGCGCCCTGGCCCCTAGGTGCAGACACACCCGCCCTGGATAACGTCTTTTTCGAGAGTCTGCAGCGGCGCCTGTCGGTGTACCGG
CAGATTGTGGATGCGCAGGCTGTGTGCACCCGCTGCAAAGAGTCGGCCGACTTCTGGTGCTTTGAGTGCGAGCAGCTCCTCTGCGCCAAGTGCTTCGAGG
CACACCAGTGGTTCCTCAAGCACGAGGCCCGGCCCCTAGCAGAGCTGCGCAACCAGTCGGTGCGTGAGTTCCTGGACGGCACCCGCAAGACCAACAACAT
CTTCTGCTCCAACCCCAACCACCGCACCCCTACGCTGACCAGCATCTACTGCCGAGGATGTTCCAAGCCGCTGTGCTGCTCGTGCGCGCTCCTTGACAGC
AGCCACAGTGAGCTCAAGTGCGACATCAGCGCAGAGATCCAGCAGCGACAGGAGGAGCTGGACGCCATGACGCAGGCGCTGCAGGAGCAGGATAGTGCCT
TTGGCGCGGTTCACGCGCAGATGCACGCGGCCGTCGGCCAGCTGGGCCGCGCGCGTGCCGAGACCGAGGAGCTGATCCGCGAGCGCGTGCGCCAGGTGGT
AGCTCACGTGCGGGCTCAGGAGCGCGAGCTGCTGGAGGCTGTGGACGCGCGGTACCAGCGCGACTACGAGGAGATGGCCAGTCGGCTGGGCCGCCTGGAT
GCTGTGCTGCAGCGCATCCGCACGGGCAGCGCGCTGGTGCAGAGGATGAAGTGCTACGCCTCGGACCAGGAGGTGCTGGACATGCACGGTTTCCTGCGCC
AGGCGCTCTGCCGCCTGCGCCAGGAGGAGCCCCAGAGCCTGCAAGCTGCCGTGCGCACCGATGGCTTCGACGAGTTCAAGGTGCGCCTGCAGGACCTCAG
CTCTTGCATCACCCAGGGGAAAGATGCAGCTGTATCCAAGAAAGCCAGCCCAGAGGCTGCCAGCACTCCCAGGGACCCTATTGACGTTGACCTGCCCGAG
GAGGCAGAGAGAGTGAAGGCCCAGGTTCAGGCCCTGGGGCTGGCTGAAGCCCAGCCTATGGCTGTGGTACAGTCAGTGCCCGGGGCACACCCCGTGCCAG
TGTACGCCTTCTCCATCAAAGGCCCTTCCTATGGAGAGGATGTCTCCAATACAACGACAGCCCAGAAGAGGAAGTGCAGCCAGACCCAGTGCCCCAGGAA
GGTCATCAAGATGGAGTCTGAGGAGGGGAAGGAGGCAAGGTTGGCTCGGAGCTCCCCGGAGCAGCCCAGGCCCAGCACCTCCAAGGCAGTCTCACCACCC
CACCTGGATGGACCGCCTAGCCCCAGGAGCCCCGTCATAGGAAGTGAGGTCTTCCTGCCCAACAGCAACCACGTGGCCAGTGGCGCCGGGGAGGCAGAGG
AACGCGTTGTGGTGATCAGCAGCTCGGAAGACTCAGATGCCGAAAACTCGGTGAGTGGCCCAGAAGTTCAGCCCAGGACTCCTGCCTCCCCCCATTTCAG
GTCCCAGGGGGCACAGCCACAGCAGGTGACTCTCAGACTTGCCTTGCGCCTGGGGAATTTTCCAGTGAGGCATTGAGTCCCAAGCTGTGCTGAGGACAGT
CTCCAAATGACAGCTGCATGCCTGGACCACCCCAGCCCTCCCACTACACCAGGGCCAGGAGCTCTTCTGAAATGCTGATAGCATGTGTCCAGAGCCCTGT
CTCTTTTCTGGAATGTCCAAGACCTTTGTCTGGAGCTTCCTTATGCATTTTCTGTCCTCTAAGTCCTCAGTGAGGAGGGCTGGACAAGAATCCATTCCTT
GGTTTATTACAGCCAGTGGGGGCCAGTGAAGGGGTGTCAGGCCACAGGGCAGCTATATAGGGGCCAAACAAGTGAGGTTTGACTCCATCCATGTAGAAAG
ATATATAAATCCATTCCACAGTGAAACAGGTGGCCTCGTGGGTAGTGACCCTTCTGTCCCTAGAGGTTTATTACTAGAGGCTGGACTATCACCTGTCCAG
GGGAAAAGGGGATCTGAATAGAGTGAAAGGTTGGACTGGGTGGCCCCTGAGGTCTCTTCCAGCCCTCAGTCTGAGGTTCTGTATTGGAAAGTGCATGGAG
CCCATGGAGACCGCCGAGCCACAGTCCTCGCCAGCCCACTCCTCGCCAGCCCACTCCTCGCCAGCCCACTCCTCGCCAGTCCAGTCTCTGCTGAGAGCAC
AAGGAGCCTCCAGCCTGCCCTGTGGCACATACCACCCCCCAGCTTGGCCTCCCCACCAGCCCGCTGAGCAGGCTGCCACCCCCGATGCTGAGCCTCACAG
CGAGCCTCCTGATCACCAGGAGCGCCCTGCCGTCCACCGTGGGATCCGCTACCTGTTGTACAGAGCACAGAGAGCCATCCGCCTTCGCCATGCCCTCCGC
TTGCACCCTCAATTGCATCGGGCCCCTATTCGGACTTGGTCTCCCCATGTGGTCCAAGCCAGCACTCCTGCCATCACAGGGCCCCTCAACCATCCTGCCA
ATGCCCAGGAACATCCTGCCCAGCTGCAAAGGGGCATCAGCCCACCCCACCGGATACGAGGGGCTGTGCGATCCCGCAGCCGCTCCCTCCGGGGCTCCTC
CCATTTATCCCAGTGGCTCAACAACTTTTTTGCCCTCCCCTTCTCCTCCATGGCTTCCCAGCTTGACATGTCTTCCGTGGTGGGGGCAGGGGAAAGCAGA
GCCCAGACTCTTGGAGCAGGTGTTCCCCCTGGGGACTCTGTCAGAGGCTCCATGGAGGCCTCTCAAGTCCAAGTGCCTCTGGAAGCCTCTCCAATTACAT
TCCCACCACCCTGTGCCCCAGAAAGGCCCCCCATCAGCCCAGTCCCAGGCGCCCGTCAAGCAGGCCTCTGAGAGTGCTACCCTTCTCTTGTAACCTTGCA
GCCAACACCCCTGCCCGGCCCCTGAGCTGCCTCCTCCAGCCCATGCTCTTACAGGCCCTGCACAGAGTAGCACTCATTAATTCTTGGTTAAGGAATGAAT
CAACGAATGAATGGCTATGCATGGACCTCTGGGCAGGGAGACCTGGGTCTTCTCTGGCTGAGAGGGGAAGGCTAAGGCATGGCTGAGATTCAAGCCACCA
TTCCAGGCCTCTTTGCCCAAGAAAGAAACTTCTGTCACCCTTGCACTCTCCTGTATTCTGAGTCCCTGGCCAATAGCACAGCCTTCCATGCCCCGACCCC
CACCCCAAGCCTCTCCACTAGGCCTCTGCCAGGATCTAAGCCCATGAGCACAGGGACTGGCTATCCCAAGACCTGGCAGATGTGGCTGCTCAATAAACAC
TTGTTGAACCATCA
  • refseq_PML.F2 (forward primer)
  • refseq_PML.R2 (reverse primer)
  • Single exon skipping

Frame 0

LSRGGP*AGTSPFGQLKGLSQLAHASPSASLHA
LQDLNRESKLSWGPWSLHPPDLRGPSRTPPGPRS
PPCLPPRPPLKAASPAPAPALQSEPPLRRRSSS
FCAASNARRKPSARSCCLVCTRCAQDAWRRRAC
SAPSARRPGP*VQTHPPWITSFSRVCSGACRCTG
RLWMRRLCAPAAKSRPTSGALSASSSSAPSASR
HTSGSSSTRPGP*QSCATSRCVSSWTAPARPTT
SSAPTPTTAPLR*PASTAEDVPSRCAARARSLTA
ATVSSSATSAQRSSSDRRSWTP*RRRCRSRIVP
LARFTRRCTRPSASWAARVPRPRS*SASACARW
*LTCGLRSASCWRLWTRGTSATTRRWPVGWAAWM
LCCSASARAARWCRG*SATPRTRRCWTCTVSCA
RRSAACARRSPRACKLPCAPMASTSSRCACRTS
ALASPRGKMQLYPRKPAQRLPALPGTLLTLTCPR
RQRE*RPRFRPWGWLKPSLWLWYSQCPGHTPCQ
CTPSPSKALPMERMSPIQRQPRRGSAARPSAPG
RSSRWSLRRGRRQGWLGAPRSSPGPAPPRQSHHP
TWMDRLAPGAPS*EVRSSCPTATTWPVAPGRQR
NALW*SAARKTQMPKTR*VAQKFSPGLLPPPIS
GPRGHSHSR*LSDLPCAWGIFQ*GIESQAVLRTV
SK*QLHAWTTPALPLHQGQELF*NADSMCPEPC
LFSGMSKTFVWSFLMHFLSSKSSVRRAGQESIP
WFITASGGQ*RGVRPQGSYIGAKQVRFDSIHVER
YINPFHSETGGLVGSDPSVPRGLLLEAGLSPVQ
GKRGSE*SERLDWVAPEVSSSPQSEVLYWKVHG
AHGDRRATVLASPLLASPLLASPLLASPVSAEST
RSLQPALWHIPPPSLASPPAR*AGCHPRC*ASQ
RAS*SPGAPCRPPWDPLPVVQSTESHPPSPCPP
LAPSIASGPYSDLVSPCGPSQHSCHHRAPQPSCQ
CPGTSCPAAKGHQPTPPDTRGCAIPQPLPPGLL
PFIPVAQQLFCPPLLLHGFPA*HVFRGGGRGKQ
SPDSWSRCSPWGLCQRLHGGLSSPSASGSLSNYI
PTTLCPRKAPHQPSPRRPSSRPLRVLPFSCNLA
ANTPARPLSCLLQPMLLQALHRVALINSWLRNE
STNEWLCMDLWAGRPGSSLAERGRLRHG*DSSHH
SRPLCPRKKLLSPLHSPVF*VPGQ*HSLPCPDP
HPKPLH*ASARI*AHEHRDWLSQDLADVAAQ*T
LVEPS

Frame 1

SPEAGPEPAPPLSDSSRDSANWLTPPLQLLFTH
SKI*TENRN*AGVHGACTRPISEAPAGPRPAPG
AHHASPRDPL*RPPAQPQPQPYRASPRFGGGVPV
SALPAMPGGSQVPEAAALSAHAVLRMPGGVGHA
VPHLPGALAPRCRHTRPG*RLFRESAAAPVGVP
ADCGCAGCVHPLQRVGRLLVL*VRAAPLRQVLRG
TPVVPQARGPAPSRAAQPVGA*VPGRHPQDQQH
LLLQPQPPHPYADQHLLPRMFQAAVLLVRAP*Q
QPQ*AQVRHQRRDPAATGGAGRHDAGAAGAG*CL
WRGSRADARGRRPAGPRACRDRGADPRARAPGG
SSRAGSGARAAGGCGRAVPARLRGDGQSAGPPG
CCAAAHPHGQRAGAEDEVLRLGPGGAGHARFPAP
GALPPAPGGAPEPASCRAHRWLRRVQGAPAGPQ
LLHHPGERCSCIQESQPRGCQHSQGPY*R*PAR
GGRESEGPGSGPGAG*SPAYGCGTVSARGTPRAS
VRLLHQRPFLWRGCLQYNDSPEEEVQPDPVPQE
GHQDGV*GGEGGKVGSELPGAAQAQHLQGSLTT
PPGWTA*PQEPRHRK*GLPAQQQPRGQWRRGGRG
TRCGDQQLGRLRCRKLGEWPRSSAQDSCLPPFQ
VPGGTATAGDSQTCLAPGEFSSEALSPKLC*GQ
SPNDSCMPGPPQPSHYTRARSSSEMLIACVQSPV
SFLECPRPLSGASLCIFCPLSPQ*GGLDKNPFL
GLLQPVGASEGVSGHRAAI*GPNK*GLTPSM*K
DI*IHSTVKQVASWVVTLLSLEVYY*RLDYHLSR
GKGDLNRVKGWTGWPLRSLPALSLRFCIGKCME
PMETAEPQSSPAHSSPAHSSPAHSSPVQSLLRA
QGASSLPCGTYHPPAWPPHQPAEQAATPDAEPHS
EPPDHQERPAVHRGIRYLLYRAQRAIRLRHALR
LHPQLHRAPIRTWSPHVVQASTPAITGPLNHPA
NAQEHPAQLQRGISPPHRIRGAVRSRSRSLRGSS
HLSQWLNNFFALPFSSMASQLDMSSVVGAGESR
AQTLGAGVPPGDSVRGSMEASQVQVPLEASPIT
FPPPCAPERPPISPVPGARQAGL*ECYPSLVTLQ
PTPLPGP*AASSSPCSYRPCTE*HSLILG*GMN
QRMNGYAWTSGQGDLGLLWLRGEG*GMAEIQAT
IPGLFAQERNFCHPCTLLYSESLANSTAFHAPTP
TPSLSTRPLPGSKPMSTGTGYPKTWQMWLLNKH
LLNH

Frame 2

LQRRALSRHLPFRTAQGTQPTGSRLPFSFSSRT
PRSKPRIETKLGSMEPAPARSPRPQQDPARPQE
PTMPPPETPSEGRQPSPSPSPTERAPASEEEFQ
FLRCQQCQAEAKCPKLLPCLHTLCSGCLEASGMQ
CPICQAPWPLGADTPALDNVFFESLQRRLSVYR
QIVDAQAVCTRCKESADFWCFECEQLLCAKCFE
AHQWFLKHEARPLAELRNQSVREFLDGTRKTNNI
FCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDS
SHSELKCDISAEIQQRQEELDAMTQALQEQDSA
FGAVHAQMHAAVGQLGRARAETEELIRERVRQVV
AHVRAQERELLEAVDARYQRDYEEMASRLGRLD
AVLQRIRTGSALVQRMKCYASDQEVLDMHGFLR
QALCRLRQEEPQSLQAAVRTDGFDEFKVRLQDLS
SCITQGKDAAVSKKASPEAASTPRDPIDVDLPE
EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVP
VYAFSIKGPSYGEDVSNTTTAQKRKCSQTQCPRK
VIKMESEEGKEARLARSSPEQPRPSTSKAVSPP
HLDGPPSPRSPVIGSEVFLPNSNHVASGAGEAE
ERVVVISSSEDSDAENSVSGPEVQPRTPASPHFR
SQGAQPQQVTLRLALRLGNFPVRH*VPSCAEDS
LQMTAACLDHPSPPTTPGPGALLKC**HVSRAL
SLFWNVQDLCLELPYAFSVL*VLSEEGWTRIHSL
VYYSQWGPVKGCQATGQLYRGQTSEV*LHPCRK
IYKSIPQ*NRWPRG**PFCP*RFITRGWTITCP
GEKGI*IE*KVGLGGP*GLFQPSV*GSVLESAWS
PWRPPSHSPRQPTPRQPTPRQPTPRQSSLC*EH
KEPPACPVAHTTPQLGLPTSPLSRLPPPMLSLT
ASLLITRSALPSTVGSATCCTEHREPSAFAMPSA
CTLNCIGPLFGLGLPMWSKPALLPSQGPSTILP
MPRNILPSCKGASAHPTGYEGLCDPAAAPSGAP
PIYPSGSTTFLPSPSPPWLPSLTCLPWWGQGKAE
PRLLEQVFPLGTLSEAPWRPLKSKCLWKPLQLH
SHHPVPQKGPPSAQSQAPVKQASESATLLL*PC
SQHPCPAPELPPPAHALTGPAQSSTH*FLVKE*I
NE*MAMHGPLGRETWVFSG*EGKAKAWLRFKPP
FQASLPKKETSVTLALSCILSPWPIAQPSMPRP
PPQASPLGLCQDLSP*AQGLAIPRPGRCGCSINT
C*TI

Sequence NM_033238

CTCTCCAGAGGCGGGCCCTGAGCCGGCACCTCCCCTTTCGGACAGCTCAAGGGACTCAGCCAACTGGCTCACGCCTCCCCTTCAGCTTCTCTTCACGCAC
TCCAAGATCTAAACCGAGAATCGAAACTAAGCTGGGGTCCATGGAGCCTGCACCCGCCCGATCTCCGAGGCCCCAGCAGGACCCCGCCCGGCCCCAGGAG
CCCACCATGCCTCCCCCCGAGACCCCCTCTGAAGGCCGCCAGCCCAGCCCCAGCCCCAGCCCTACAGAGCGAGCCCCCGCTTCGGAGGAGGAGTTCCAGT
TTCTGCGCTGCCAGCAATGCCAGGCGGAAGCCAAGTGCCCGAAGCTGCTGCCTTGTCTGCACACGCTGTGCTCAGGATGCCTGGAGGCGTCGGGCATGCA
GTGCCCCATCTGCCAGGCGCCCTGGCCCCTAGGTGCAGACACACCCGCCCTGGATAACGTCTTTTTCGAGAGTCTGCAGCGGCGCCTGTCGGTGTACCGG
CAGATTGTGGATGCGCAGGCTGTGTGCACCCGCTGCAAAGAGTCGGCCGACTTCTGGTGCTTTGAGTGCGAGCAGCTCCTCTGCGCCAAGTGCTTCGAGG
CACACCAGTGGTTCCTCAAGCACGAGGCCCGGCCCCTAGCAGAGCTGCGCAACCAGTCGGTGCGTGAGTTCCTGGACGGCACCCGCAAGACCAACAACAT
CTTCTGCTCCAACCCCAACCACCGCACCCCTACGCTGACCAGCATCTACTGCCGAGGATGTTCCAAGCCGCTGTGCTGCTCGTGCGCGCTCCTTGACAGC
AGCCACAGTGAGCTCAAGTGCGACATCAGCGCAGAGATCCAGCAGCGACAGGAGGAGCTGGACGCCATGACGCAGGCGCTGCAGGAGCAGGATAGTGCCT
TTGGCGCGGTTCACGCGCAGATGCACGCGGCCGTCGGCCAGCTGGGCCGCGCGCGTGCCGAGACCGAGGAGCTGATCCGCGAGCGCGTGCGCCAGGTGGT
AGCTCACGTGCGGGCTCAGGAGCGCGAGCTGCTGGAGGCTGTGGACGCGCGGTACCAGCGCGACTACGAGGAGATGGCCAGTCGGCTGGGCCGCCTGGAT
GCTGTGCTGCAGCGCATCCGCACGGGCAGCGCGCTGGTGCAGAGGATGAAGTGCTACGCCTCGGACCAGGAGGTGCTGGACATGCACGGTTTCCTGCGCC
AGGCGCTCTGCCGCCTGCGCCAGGAGGAGCCCCAGAGCCTGCAAGCTGCCGTGCGCACCGATGGCTTCGACGAGTTCAAGGTGCGCCTGCAGGACCTCAG
CTCTTGCATCACCCAGGGGAAAGATGCAGCTGTATCCAAGAAAGCCAGCCCAGAGGCTGCCAGCACTCCCAGGGACCCTATTGACGTTGACCTGCCCGAG
GAGGCAGAGAGAGTGAAGGCCCAGGTTCAGGCCCTGGGGCTGGCTGAAGCCCAGCCTATGGCTGTGGTACAGTCAGTGCCCGGGGCACACCCCGTGCCAG
TGTACGCCTTCTCCATCAAAGGCCCTTCCTATGGAGAGGATGTCTCCAATACAACGACAGCCCAGAAGAGGAAGTGCAGCCAGACCCAGTGCCCCAGGAA
GGTCATCAAGATGGAGTCTGAGGAGGGGAAGGAGGCAAGGTTGGCTCGGAGCTCCCCGGAGCAGCCCAGGCCCAGCACCTCCAAGGCAGTCTCACCACCC
CACCTGGATGGACCGCCTAGCCCCAGGAGCCCCGTCATAGGAAGTGAGGTCTTCCTGCCCAACAGCAACCACGTGGCCAGTGGCGCCGGGGAGGCAGAGG
AACGCGTTGTGGTGATCAGCAGCTCGGAAGACTCAGATGCCGAAAACTCGTCCTCCCGAGAGCTGGATGACAGCAGCAGTGAGTCCAGTGACCTCCAGCT
GGAAGGCCCCAGCACCCTCAGGGTCCTGGACGAGAACCTTGCTGACCCCCAAGCAGAAGACAGACCTCTGGTTTTCTTTGACCTCAAGATTGACAATGAA
ACCCAGAAGATTAGCCAGCTGGCTGCGGTGAACCGGGAAAGCAAGTTCCGCGTGGTCATCCAGCCTGAAGCCTTCTTCAGCATCTACTCCAAGGCCGTGT
CCCTGGAGGTGGGGCTGCAGCACTTCCTCAGCTTTCTGAGCTCCATGCGCCGCCCTATCTTGGCCTGCTACAAGCTGTGGGGGCCTGGCCTCCCAAACTT
CTTCCGGGCCCTGGAGGACATTAACAGGCTGTGGGAATTCCAGGAGGCCATCTCGGGCTTCCTGGCTGCCCTGCCTCTCATCCGGGAGCGTGTGCCCGGG
GCCAGCAGCTTCAAACTCAAGAACCTGGCCCAGACCTACCTGGCGAGAAACATGAGCGAGCGCAGCGCCATGGCTGCCGTGCTGGCCATGCGTGACCTGT
GCCGCCTCCTCGAGGTCTCCCCGGGCCCCCAGCTGGCCCAGCATGTCTACCCCTTCAGTAGCCTGCAGTGCTTTGCCTCCCTGCAGCCCCTGGTGCAGGC
AGCTGTGCTGCCCCGGGCTGAGGCCCGCCTCCTGGCCCTACACAACGTGAGCTTCATGGAGCTGCTGAGTGCACACCGCCGTGACCGGCAGGGGGGCCTG
AAGAAGTACAGCCGCTATCTAAGCCTGCAGACCACCACGTTGCCCCCTGCCCAGCCTGCTTTCAACCTGCAGGCTCTGGGCACCTACTTTGAAGGCCTGT
TGGAGGGTCCGGCGCTGGCACGGGCAGAAGGAGTCTCCACCCCACTTGCTGGCCGTGGCTTGGCAGAGAGGGCCTCCCAGCAGAGCTGAGAGGAGGGGGT
GACCAGCTTGGAGTCTCTGGTGGGCAGAGAGGGATGGGGTCCCTGAGCCAGGCCCCACCCATCACAGCATTCCCAGGTCCTGGTACCCAGCCCTCAGTTG
TCATTTGGTTCAGAATCAGTTCCCTTTCTCTGGGACCAAATTTCCCTTCTCTAAACATCCTACAGAGAAGGTTCCAAAGCTGAGCACCCATCACCCTAGG
TGTGCACCAGACTCCTATTAGCCCCTCCTTCCAGGAGCTAGAACCAGGGAGGTCCTGAGTGAGGAAGGCATGACCTCTGGGCTCTCTAGGTGGCCCTGGT
CTTGCCCCATCCATCCCACCTGCCACTACCTTGGGTGTCCTTACAGCTCTGCCCTGACCCCAGCCCCTGCCCCTGGACACCTGCTGACAGCTCCCACACA
GAACAGTCTGAGGTGATGCTGGCTACAGCCCTGGCAGCCCATGGCAACTCAAAGTGCCTTCCAAACCAAACTGCCCCTCATGAGGTTAGGGTCCCCCACC
CTCCACCTGCCCAGAGGCCAACTCTGTTCCCTTCTCCTTTCATCCCAGAGGGGCCTCATCAGCAAAGACAGAAACTGATGTTCCATGCATGTCCCTGCTT
CCAAAGCCTGACCTTCCAAAGCTTGCTTCCTTCCTCCTGGCTGCACAGACACCTCTGCTTGGCCACAGCTTTGCTCTTTGGTCCTCAGGCCACCAGACCC
CTCACAGCATGGCCCTTGGCTCTTCCTGCACTGCCCTCACCCTCAGCCGTCCCAAGGAGTGCCCAGCACTACTCAGCATGTAGTCCAGGACCTGCGGCAT
CAGCATCCCCTGGGAGCTTCTTAGAAATGCAGACCTGTGGGCTCTACCACAGGCCTCTGGAATCAGAATCTTCAGGGTGGGGCCCAGCAGTCTGTGTTTT
AACAGGTTCTCCCGGTGATGCTGGTGCATGCTCAAGTTTGAGAACCGCTGCTCTCATAGACTGCTCCTCCAAGGGGAAGCAGTGTGGAACAGCAGAGAAA
GTCCCGTCCCTATCTCTGACTGTGCAGTGAGTGTGGCCTAGGAACAGGTCCCTTCCTAAGCTCTAGTGTCCCCATCTGTAAAATGGGCTGATTGGCCTCC
ACGGTCAGAGCGGCCATCTGGCTGTGCCATCCTGCATTTTTAGGAATGGAAAGCAGGCCTCTGAGGCAGTGGACAGGAAGACTTCTCATCCTTGAATTCT
AGCTCCCATTCCAAACTGTTAGTCCCCAACCTTGTGGTCACATCAGAGGTCAACAGCAGAACAGAGGCAGGTCAGGGTTGTCCGCTCTGATTAGCAGAAC
GACAGCCCCTTCCTCCTCCTCCCTCCTTCCCATCCCTACTCATTAGCTCCCTGCTCCTGGGATGCTTCCCAAGCAGCCCAGGCCTCTAGCCTCCATGGCT
GATGACCTCAGCTTTCACACTGGTGAAGTCTGTGTACCCATACTGCAGCCCCATCCCATGGGGCCCCTGAAGACCCACTGAGGAATTCCGTAGGGTCTTG
TTCCCACGACCGGAGTGCTGGCTCTCACAGTGAATTTTGATGCATTTAAAATAAGATTCTGATGCCAGACTGTTAAAACAGGCGCTGGTTCTGAAGCACC
GATGGAAACAGATTGATGCAGATGGAAGGAGGAAGGGAGACTGGGCCCACTGATTTCCAGCCCCACCATGTGTGCTGTTTTCAGATGTGATTGAGGGGTG
TTCTGCCCTGCCTCCACTGTCACAGCCTTTAATAAAGATGTGAATCTTGAAAGCCTGATGCTCCAATCACAGACTCTGCTCAGCATCCCCAGAGGAACCA
CTGAGAAGCCTTTTGCCTGGATAGGAGGGGGCTCTCCCAGGCATAGGCTTGTGGCCACTTGCCCAGCACAACTGTGTTTTGTGGGGCGTCTTTTAGGACT
TAGCAGAGCTGAGAGCCCTTTGTTGCTCAATGCTGTGAGCCTTAAGCATGTGAATCCCCCCACATGACAAGTGGGGAGACCCAGGGTAGGCTTTCCTTTG
GATCATCTCCAAATGGGAGTGCCATGTGGCAGGAAAGAAGCACCGATTTCAAGAATTACTTCCTAGAGAAAGTCAGGAACTAGAGACCAGAGTCTGCAGG
AACTTTGCCACTGCCCTTCACTGGCTAATCCTGTACTTCTCTCTGTGTTCCTTGAGTGACAGGTGGTAAAACCCTTAAAAAGGGAGGTGTGGGAGGCCCA
GGACTTTGGTAACAGGTGATGAATGTGTTGTCTTGGCCATCACAGGTGGAGCTTCAGTTAGTACCCGAGGGATTCCCCTGGCACAAGCATTATAGGAATT
AGTCCACCACTGGCGTGGGTGAGCAGCCAGGTAATGGGAATTGATCAGTGCCACCACCCTTGACCCCAACTACCATCCCAGATGCCCAGATTCCAGTCCT
GGAGTTTTATTCTCTCAGCTTGATCCTTTGACCAAGAAGATCCAGTCCCAATATGTCACCTGTGCTTCATCTTTGGACTATATCTCAGGTGTTTACGTGT
CAACTAATGGGAGCTTACTGGGTTAGAAGTCAGGACACTGAGTTTCAATCCTCACTTAGTAGTCTGTGGCCCTCTTTGGCACATTAACCTCCCTCCTTGA
TCCTCAGGCTGCACCTCTGGCAAATGGGAGAATGCGGCTCCTTTTGACTTCAAGGGATCTTTGTGGGAACCAATGAGAAAATGTGTGTGAAGATAGCTTT
TTGGTATATTTTAAAAGTGCACAAATTTAAGATCTTACTGCTTTATAAAGTGCTTTATGAATTATAGGAAAATAAACACATTTTAGATCTTAGAAAAAAA
  • refseq_PML.F2 (forward primer)
  • refseq_PML.R2 (reverse primer)
  • Single exon skipping

Frame 0

LSRGGP*AGTSPFGQLKGLSQLAHASPSASLHA
LQDLNRESKLSWGPWSLHPPDLRGPSRTPPGPRS
PPCLPPRPPLKAASPAPAPALQSEPPLRRRSSS
FCAASNARRKPSARSCCLVCTRCAQDAWRRRAC
SAPSARRPGP*VQTHPPWITSFSRVCSGACRCTG
RLWMRRLCAPAAKSRPTSGALSASSSSAPSASR
HTSGSSSTRPGP*QSCATSRCVSSWTAPARPTT
SSAPTPTTAPLR*PASTAEDVPSRCAARARSLTA
ATVSSSATSAQRSSSDRRSWTP*RRRCRSRIVP
LARFTRRCTRPSASWAARVPRPRS*SASACARW
*LTCGLRSASCWRLWTRGTSATTRRWPVGWAAWM
LCCSASARAARWCRG*SATPRTRRCWTCTVSCA
RRSAACARRSPRACKLPCAPMASTSSRCACRTS
ALASPRGKMQLYPRKPAQRLPALPGTLLTLTCPR
RQRE*RPRFRPWGWLKPSLWLWYSQCPGHTPCQ
CTPSPSKALPMERMSPIQRQPRRGSAARPSAPG
RSSRWSLRRGRRQGWLGAPRSSPGPAPPRQSHHP
TWMDRLAPGAPS*EVRSSCPTATTWPVAPGRQR
NALW*SAARKTQMPKTRPPESWMTAAVSPVTSS
WKAPAPSGSWTRTLLTPKQKTDLWFSLTSRLTMK
PRRLASWLR*TGKASSAWSSSLKPSSASTPRPC
PWRWGCSTSSAF*APCAALSWPATSCGGLASQT
SSGPWRTLTGCGNSRRPSRASWLPCLSSGSVCPG
PAASNSRTWPRPTWRET*ASAAPWLPCWPCVTC
AASSRSPRAPSWPSMSTPSVACSALPPCSPWCR
QLCCPGLRPASWPYTT*ASWSC*VHTAVTGRGA*
RSTAAI*ACRPPRCPLPSLLSTCRLWAPTLKAC
WRVRRWHGQKESPPHLLAVAWQRGPPSRAERRG
*PAWSLWWAERDGVPEPGPTHHSIPRSWYPALSC
HLVQNQFPFSGTKFPFSKHPTEKVPKLSTHHPR
CAPDSY*PLLPGARTREVLSEEGMTSGLSRWPW
SCPIHPTCHYLGCPYSSALTPAPAPGHLLTAPTQ
NSLR*CWLQPWQPMATQSAFQTKLPLMRLGSPT
LHLPRGQLCSLLLSSQRGLISKDRN*CSMHVPA
SKA*PSKACFLPPGCTDTSAWPQLCSLVLRPPDP
SQHGPWLFLHCPHPQPSQGVPSTTQHVVQDLRH
QHPLGAS*KCRPVGSTTGLWNQNLQGGAQQSVF
*QVLPVMLVHAQV*EPLLS*TAPPRGSSVEQQRK
SRPYL*LCSECGLGTGPFLSSSVPICKMG*LAS
TVRAAIWLCHPAFLGMESRPLRQWTGRLLILEF
*LPFQTVSPQPCGHIRGQQQNRGRSGLSALISRT
TAPSSSSLLPIPTH*LPAPGMLPKQPRPLASMA
DDLSFHTGEVCVPILQPHPMGPLKTH*GIP*GL
VPTTGVLALTVNFDAFKIRF*CQTVKTGAGSEAP
METD*CRWKEEGRLGPLISSPTMCAVFRCD*GV
FCPASTVTAFNKDVNLESLMLQSQTLLSIPRGT
TEKPFAWIGGGSPRHRLVATCPAQLCFVGRLLGL
SRAESPLLLNAVSLKHVNPPT*QVGRPRVGFPL
DHLQMGVPCGRKEAPISRITS*RKSGTRDQSLQ
ELCHCPSLANPVLLSVFLE*QVVKPLKREVWEAQ
DFGNR**MCCLGHHRWSFS*YPRDSPGTSIIGI
SPPLAWVSSQVMGIDQCHHP*PQLPSQMPRFQS
WSFILSA*SFDQEDPVPICHLCFIFGLYLRCLRV
N*WELTGLEVRTLSFNPHLVVCGPLWHINLPP*
SSGCTSGKWENAAPFDFKGSLWEPMRKCV*R*L
FGIF*KCTNLRSYCFIKCFMNYRKINTF*ILEK

Frame 1

SPEAGPEPAPPLSDSSRDSANWLTPPLQLLFTH
SKI*TENRN*AGVHGACTRPISEAPAGPRPAPG
AHHASPRDPL*RPPAQPQPQPYRASPRFGGGVPV
SALPAMPGGSQVPEAAALSAHAVLRMPGGVGHA
VPHLPGALAPRCRHTRPG*RLFRESAAAPVGVP
ADCGCAGCVHPLQRVGRLLVL*VRAAPLRQVLRG
TPVVPQARGPAPSRAAQPVGA*VPGRHPQDQQH
LLLQPQPPHPYADQHLLPRMFQAAVLLVRAP*Q
QPQ*AQVRHQRRDPAATGGAGRHDAGAAGAG*CL
WRGSRADARGRRPAGPRACRDRGADPRARAPGG
SSRAGSGARAAGGCGRAVPARLRGDGQSAGPPG
CCAAAHPHGQRAGAEDEVLRLGPGGAGHARFPAP
GALPPAPGGAPEPASCRAHRWLRRVQGAPAGPQ
LLHHPGERCSCIQESQPRGCQHSQGPY*R*PAR
GGRESEGPGSGPGAG*SPAYGCGTVSARGTPRAS
VRLLHQRPFLWRGCLQYNDSPEEEVQPDPVPQE
GHQDGV*GGEGGKVGSELPGAAQAQHLQGSLTT
PPGWTA*PQEPRHRK*GLPAQQQPRGQWRRGGRG
TRCGDQQLGRLRCRKLVLPRAG*QQQ*VQ*PPA
GRPQHPQGPGREPC*PPSRRQTSGFL*PQD*Q*
NPED*PAGCGEPGKQVPRGHPA*SLLQHLLQGRV
PGGGAAALPQLSELHAPPYLGLLQAVGAWPPKL
LPGPGGH*QAVGIPGGHLGLPGCPASHPGACAR
GQQLQTQEPGPDLPGEKHERAQRHGCRAGHA*PV
PPPRGLPGPPAGPACLPLQ*PAVLCLPAAPGAG
SCAAPG*GPPPGPTQRELHGAAECTPP*PAGGP
EEVQPLSKPADHHVAPCPACFQPAGSGHLL*RPV
GGSGAGTGRRSLHPTCWPWLGREGLPAELRGGG
DQLGVSGGQRGMGSLSQAPPITAFPGPGTQPSV
VIWFRISSLSLGPNFPSLNILQRRFQS*APITLG
VHQTPISPSFQELEPGRS*VRKA*PLGSLGGPG
LAPSIPPATTLGVLTALP*PQPLPLDTC*QLPH
RTV*GDAGYSPGSPWQLKVPSKPNCPS*G*GPPP
STCPEANSVPFSFHPRGASSAKTETDVPCMSLL
PKPDLPKLASFLLAAQTPLLGHSFALWSSGHQT
PHSMALGSSCTALTLSRPKECPALLSM*SRTCGI
SIPWELLRNADLWALPQASGIRIFRVGPSSLCF
NRFSR*CWCMLKFENRCSHRLLLQGEAVWNSRE
SPVPISDCAVSVA*EQVPS*ALVSPSVKWADWPP
RSERPSGCAILHF*EWKAGL*GSGQEDFSSLNS
SSHSKLLVPNLVVTSEVNSRTEAGQGCPL*LAE
RQPLPPPPSFPSLLISSLLLGCFPSSPGL*PPWL
MTSAFTLVKSVYPYCSPIPWGP*RPTEEFRRVL
FPRPECWLSQ*ILMHLK*DSDARLLKQALVLKH
RWKQIDADGRRKGDWAH*FPAPPCVLFSDVIEGC
SALPPLSQPLIKM*ILKA*CSNHRLCSASPEEP
LRSLLPG*EGALPGIGLWPLAQHNCVLWGVF*D
LAELRALCCSML*ALSM*IPPHDKWGDPG*AFLW
IISKWECHVAGKKHRFQELLPRESQELETRVCR
NFATALHWLILYFSLCSLSDRW*NP*KGRCGRP
RTLVTGDECVVLAITGGASVSTRGIPLAQAL*EL
VHHWRG*AAR*WELISATTLDPNYHPRCPDSSP
GVLFSQLDPLTKKIQSQYVTCASSLDYISGVYV
STNGSLLG*KSGH*VSILT**SVALFGTLTSLLD
PQAAPLANGRMRLLLTSRDLCGNQ*ENVCEDSF
LVYFKSAQI*DLTAL*SAL*IIGK*THFRS*KK

Frame 2

LQRRALSRHLPFRTAQGTQPTGSRLPFSFSSRT
PRSKPRIETKLGSMEPAPARSPRPQQDPARPQE
PTMPPPETPSEGRQPSPSPSPTERAPASEEEFQ
FLRCQQCQAEAKCPKLLPCLHTLCSGCLEASGMQ
CPICQAPWPLGADTPALDNVFFESLQRRLSVYR
QIVDAQAVCTRCKESADFWCFECEQLLCAKCFE
AHQWFLKHEARPLAELRNQSVREFLDGTRKTNNI
FCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDS
SHSELKCDISAEIQQRQEELDAMTQALQEQDSA
FGAVHAQMHAAVGQLGRARAETEELIRERVRQVV
AHVRAQERELLEAVDARYQRDYEEMASRLGRLD
AVLQRIRTGSALVQRMKCYASDQEVLDMHGFLR
QALCRLRQEEPQSLQAAVRTDGFDEFKVRLQDLS
SCITQGKDAAVSKKASPEAASTPRDPIDVDLPE
EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVP
VYAFSIKGPSYGEDVSNTTTAQKRKCSQTQCPRK
VIKMESEEGKEARLARSSPEQPRPSTSKAVSPP
HLDGPPSPRSPVIGSEVFLPNSNHVASGAGEAE
ERVVVISSSEDSDAENSSSRELDDSSSESSDLQL
EGPSTLRVLDENLADPQAEDRPLVFFDLKIDNE
TQKISQLAAVNRESKFRVVIQPEAFFSIYSKAV
SLEVGLQHFLSFLSSMRRPILACYKLWGPGLPNF
FRALEDINRLWEFQEAISGFLAALPLIRERVPG
ASSFKLKNLAQTYLARNMSERSAMAAVLAMRDL
CRLLEVSPGPQLAQHVYPFSSLQCFASLQPLVQA
AVLPRAEARLLALHNVSFMELLSAHRRDRQGGL
KKYSRYLSLQTTTLPPAQPAFNLQALGTYFEGL
LEGPALARAEGVSTPLAGRGLAERASQQS*EEGV
TSLESLVGREGWGP*ARPHPSQHSQVLVPSPQL
SFGSESVPFLWDQISLL*TSYREGSKAEHPSP*
VCTRLLLAPPSRS*NQGGPE*GRHDLWAL*VALV
LPHPSHLPLPWVSLQLCPDPSPCPWTPADSSHT
EQSEVMLATALAAHGNSKCLPNQTAPHEVRVPH
PPPAQRPTLFPSPFIPEGPHQQRQKLMFHACPCF
QSLTFQSLLPSSWLHRHLCLATALLFGPQATRP
LTAWPLALPALPSPSAVPRSAQHYSACSPGPAA
SASPGSFLEMQTCGLYHRPLESESSGWGPAVCVL
TGSPGDAGACSSLRTAALIDCSSKGKQCGTAEK
VPSLSLTVQ*VWPRNRSLPKL*CPHL*NGLIGL
HGQSGHLAVPSCIFRNGKQASEAVDRKTSHP*IL
APIPNC*SPTLWSHQRSTAEQRQVRVVRSD*QN
DSPFLLLPPSHPYSLAPCSWDASQAAQASSLHG
**PQLSHW*SLCTHTAAPSHGAPEDPLRNSVGSC
SHDRSAGSHSEF*CI*NKILMPDC*NRRWF*ST
DGNRLMQMEGGRETGPTDFQPHHVCCFQM*LRG
VLPCLHCHSL**RCES*KPDAPITDSAQHPQRNH
*EAFCLDRRGLSQA*ACGHLPSTTVFCGASFRT
*QS*EPFVAQCCEP*ACESPHMTSGETQGRLSF
GSSPNGSAMWQERSTDFKNYFLEKVRN*RPESAG
TLPLPFTG*SCTSLCVP*VTGGKTLKKGGVGGP
GLW*QVMNVLSWPSQVELQLVPEGFPWHKHYRN
*STTGVGEQPGNGN*SVPPPLTPTTIPDAQIPVL
EFYSLSLIL*PRRSSPNMSPVLHLWTISQVFTC
QLMGAYWVRSQDTEFQSSLSSLWPSLAH*PPSL
ILRLHLWQMGECGSF*LQGIFVGTNEKMCVKIAF
WYILKVHKFKILLLYKVLYEL*ENKHILDLRKK

Sequence NM_033244

CTCTCCAGAGGCGGGCCCTGAGCCGGCACCTCCCCTTTCGGACAGCTCAAGGGACTCAGCCAACTGGCTCACGCCTCCCCTTCAGCTTCTCTTCACGCAC
TCCAAGATCTAAACCGAGAATCGAAACTAAGCTGGGGTCCATGGAGCCTGCACCCGCCCGATCTCCGAGGCCCCAGCAGGACCCCGCCCGGCCCCAGGAG
CCCACCATGCCTCCCCCCGAGACCCCCTCTGAAGGCCGCCAGCCCAGCCCCAGCCCCAGCCCTACAGAGCGAGCCCCCGCTTCGGAGGAGGAGTTCCAGT
TTCTGCGCTGCCAGCAATGCCAGGCGGAAGCCAAGTGCCCGAAGCTGCTGCCTTGTCTGCACACGCTGTGCTCAGGATGCCTGGAGGCGTCGGGCATGCA
GTGCCCCATCTGCCAGGCGCCCTGGCCCCTAGGTGCAGACACACCCGCCCTGGATAACGTCTTTTTCGAGAGTCTGCAGCGGCGCCTGTCGGTGTACCGG
CAGATTGTGGATGCGCAGGCTGTGTGCACCCGCTGCAAAGAGTCGGCCGACTTCTGGTGCTTTGAGTGCGAGCAGCTCCTCTGCGCCAAGTGCTTCGAGG
CACACCAGTGGTTCCTCAAGCACGAGGCCCGGCCCCTAGCAGAGCTGCGCAACCAGTCGGTGCGTGAGTTCCTGGACGGCACCCGCAAGACCAACAACAT
CTTCTGCTCCAACCCCAACCACCGCACCCCTACGCTGACCAGCATCTACTGCCGAGGATGTTCCAAGCCGCTGTGCTGCTCGTGCGCGCTCCTTGACAGC
AGCCACAGTGAGCTCAAGTGCGACATCAGCGCAGAGATCCAGCAGCGACAGGAGGAGCTGGACGCCATGACGCAGGCGCTGCAGGAGCAGGATAGTGCCT
TTGGCGCGGTTCACGCGCAGATGCACGCGGCCGTCGGCCAGCTGGGCCGCGCGCGTGCCGAGACCGAGGAGCTGATCCGCGAGCGCGTGCGCCAGGTGGT
AGCTCACGTGCGGGCTCAGGAGCGCGAGCTGCTGGAGGCTGTGGACGCGCGGTACCAGCGCGACTACGAGGAGATGGCCAGTCGGCTGGGCCGCCTGGAT
GCTGTGCTGCAGCGCATCCGCACGGGCAGCGCGCTGGTGCAGAGGATGAAGTGCTACGCCTCGGACCAGGAGGTGCTGGACATGCACGGTTTCCTGCGCC
AGGCGCTCTGCCGCCTGCGCCAGGAGGAGCCCCAGAGCCTGCAAGCTGCCGTGCGCACCGATGGCTTCGACGAGTTCAAGGTGCGCCTGCAGGACCTCAG
CTCTTGCATCACCCAGGGGAAAGATGCAGCTGTATCCAAGAAAGCCAGCCCAGAGGCTGCCAGCACTCCCAGGGACCCTATTGACGTTGACCTGCCCGAG
GAGGCAGAGAGAGTGAAGGCCCAGGTTCAGGCCCTGGGGCTGGCTGAAGCCCAGCCTATGGCTGTGGTACAGTCAGTGCCCGGGGCACACCCCGTGCCAG
TGTACGCCTTCTCCATCAAAGGCCCTTCCTATGGAGAGGATGTCTCCAATACAACGACAGCCCAGAAGAGGAAGTGCAGCCAGACCCAGTGCCCCAGGAA
GGTCATCAAGATGGAGTCTGAGGAGGGGAAGGAGGCAAGGTTGGCTCGGAGCTCCCCGGAGCAGCCCAGGCCCAGCACCTCCAAGGCAGTCTCACCACCC
CACCTGGATGGACCGCCTAGCCCCAGGAGCCCCGTCATAGGAAGTGAGGTCTTCCTGCCCAACAGCAACCACGTGGCCAGTGGCGCCGGGGAGGCAGGTA
GGGAGAGGAACGCGTTGTGGTGATCAGCAGCTCGGAAGACTCAGATGCCGAAAACTCGTGCATGGAGCCCATGGAGACCGCCGAGCCACAGTCCTCGCCA
GCCCACTCCTCGCCAGCCCACTCCTCGCCAGCCCACTCCTCGCCAGTCCAGTCTCTGCTGAGAGCACAAGGAGCCTCCAGCCTGCCCTGTGGCACATACC
ACCCCCCAGCTTGGCCTCCCCACCAGCCCGCTGAGCAGGCTGCCACCCCCGATGCTGAGCCTCACAGCGAGCCTCCTGATCACCAGGAGCGCCCTGCCGT
CCACCGTGGGATCCGCTACCTGTTGTACAGAGCACAGAGAGCCATCCGCCTTCGCCATGCCCTCCGCTTGCACCCTCAATTGCATCGGGCCCCTATTCGG
ACTTGGTCTCCCCATGTGGTCCAAGCCAGCACTCCTGCCATCACAGGGCCCCTCAACCATCCTGCCAATGCCCAGGAACATCCTGCCCAGCTGCAAAGGG
GCATCAGCCCACCCCACCGGATACGAGGGGCTGTGCGATCCCGCAGCCGCTCCCTCCGGGGCTCCTCCCATTTATCCCAGTGGCTCAACAACTTTTTTGC
CCTCCCCTTCTCCTCCATGGCTTCCCAGCTTGACATGTCTTCCGTGGTGGGGGCAGGGGAAAGCAGAGCCCAGACTCTTGGAGCAGGTGTTCCCCCTGGG
GACTCTGTCAGAGGCTCCATGGAGGCCTCTCAAGTCCAAGTGCCTCTGGAAGCCTCTCCAATTACATTCCCACCACCCTGTGCCCCAGAAAGGCCCCCCA
TCAGCCCAGTCCCAGGCGCCCGTCAAGCAGGCCTCTGAGAGTGCTACCCTTCTCTTGTAACCTTGCAGCCAACACCCCTGCCCGGCCCCTGAGCTGCCTC
CTCCAGCCCATGCTCTTACAGGCCCTGCACAGAGTAGCACTCATTAATTCTTGGTTAAGGAATGAATCAACGAATGAATGGCTATGCATGGACCTCTGGG
CAGGGAGACCTGGGTCTTCTCTGGCTGAGAGGGGAAGGCTAAGGCATGGCTGAGATTCAAGCCACCATTCCAGGCCTCTTTGCCCAAGAAAGAAACTTCT
GTCACCCTTGCACTCTCCTGTATTCTGAGTCCCTGGCCAATAGCACAGCCTTCCATGCCCCGACCCCCACCCCAAGCCTCTCCACTAGGCCTCTGCCAGG
ATCTAAGCCCATGAGCACAGGGACTGGCTATCCCAAGACCTGGCAGATGTGGCTGCTCAATAAACACTTGTTGAACCATCA
  • refseq_PML.F2 (forward primer)
  • refseq_PML.R2 (reverse primer)
  • Single exon skipping

Frame 0

LSRGGP*AGTSPFGQLKGLSQLAHASPSASLHA
LQDLNRESKLSWGPWSLHPPDLRGPSRTPPGPRS
PPCLPPRPPLKAASPAPAPALQSEPPLRRRSSS
FCAASNARRKPSARSCCLVCTRCAQDAWRRRAC
SAPSARRPGP*VQTHPPWITSFSRVCSGACRCTG
RLWMRRLCAPAAKSRPTSGALSASSSSAPSASR
HTSGSSSTRPGP*QSCATSRCVSSWTAPARPTT
SSAPTPTTAPLR*PASTAEDVPSRCAARARSLTA
ATVSSSATSAQRSSSDRRSWTP*RRRCRSRIVP
LARFTRRCTRPSASWAARVPRPRS*SASACARW
*LTCGLRSASCWRLWTRGTSATTRRWPVGWAAWM
LCCSASARAARWCRG*SATPRTRRCWTCTVSCA
RRSAACARRSPRACKLPCAPMASTSSRCACRTS
ALASPRGKMQLYPRKPAQRLPALPGTLLTLTCPR
RQRE*RPRFRPWGWLKPSLWLWYSQCPGHTPCQ
CTPSPSKALPMERMSPIQRQPRRGSAARPSAPG
RSSRWSLRRGRRQGWLGAPRSSPGPAPPRQSHHP
TWMDRLAPGAPS*EVRSSCPTATTWPVAPGRQV
GRGTRCGDQQLGRLRCRKLVHGAHGDRRATVLA
SPLLASPLLASPLLASPVSAESTRSLQPALWHIP
PPSLASPPAR*AGCHPRC*ASQRAS*SPGAPCR
PPWDPLPVVQSTESHPPSPCPPLAPSIASGPYS
DLVSPCGPSQHSCHHRAPQPSCQCPGTSCPAAKG
HQPTPPDTRGCAIPQPLPPGLLPFIPVAQQLFC
PPLLLHGFPA*HVFRGGGRGKQSPDSWSRCSPW
GLCQRLHGGLSSPSASGSLSNYIPTTLCPRKAPH
QPSPRRPSSRPLRVLPFSCNLAANTPARPLSCL
LQPMLLQALHRVALINSWLRNESTNEWLCMDLW
AGRPGSSLAERGRLRHG*DSSHHSRPLCPRKKLL
SPLHSPVF*VPGQ*HSLPCPDPHPKPLH*ASAR
I*AHEHRDWLSQDLADVAAQ*TLVEPS

Frame 1

SPEAGPEPAPPLSDSSRDSANWLTPPLQLLFTH
SKI*TENRN*AGVHGACTRPISEAPAGPRPAPG
AHHASPRDPL*RPPAQPQPQPYRASPRFGGGVPV
SALPAMPGGSQVPEAAALSAHAVLRMPGGVGHA
VPHLPGALAPRCRHTRPG*RLFRESAAAPVGVP
ADCGCAGCVHPLQRVGRLLVL*VRAAPLRQVLRG
TPVVPQARGPAPSRAAQPVGA*VPGRHPQDQQH
LLLQPQPPHPYADQHLLPRMFQAAVLLVRAP*Q
QPQ*AQVRHQRRDPAATGGAGRHDAGAAGAG*CL
WRGSRADARGRRPAGPRACRDRGADPRARAPGG
SSRAGSGARAAGGCGRAVPARLRGDGQSAGPPG
CCAAAHPHGQRAGAEDEVLRLGPGGAGHARFPAP
GALPPAPGGAPEPASCRAHRWLRRVQGAPAGPQ
LLHHPGERCSCIQESQPRGCQHSQGPY*R*PAR
GGRESEGPGSGPGAG*SPAYGCGTVSARGTPRAS
VRLLHQRPFLWRGCLQYNDSPEEEVQPDPVPQE
GHQDGV*GGEGGKVGSELPGAAQAQHLQGSLTT
PPGWTA*PQEPRHRK*GLPAQQQPRGQWRRGGR*
GEERVVVISSSEDSDAENSCMEPMETAEPQSSP
AHSSPAHSSPAHSSPVQSLLRAQGASSLPCGTY
HPPAWPPHQPAEQAATPDAEPHSEPPDHQERPAV
HRGIRYLLYRAQRAIRLRHALRLHPQLHRAPIR
TWSPHVVQASTPAITGPLNHPANAQEHPAQLQR
GISPPHRIRGAVRSRSRSLRGSSHLSQWLNNFFA
LPFSSMASQLDMSSVVGAGESRAQTLGAGVPPG
DSVRGSMEASQVQVPLEASPITFPPPCAPERPP
ISPVPGARQAGL*ECYPSLVTLQPTPLPGP*AAS
SSPCSYRPCTE*HSLILG*GMNQRMNGYAWTSG
QGDLGLLWLRGEG*GMAEIQATIPGLFAQERNF
CHPCTLLYSESLANSTAFHAPTPTPSLSTRPLPG
SKPMSTGTGYPKTWQMWLLNKHLLNH

Frame 2

LQRRALSRHLPFRTAQGTQPTGSRLPFSFSSRT
PRSKPRIETKLGSMEPAPARSPRPQQDPARPQE
PTMPPPETPSEGRQPSPSPSPTERAPASEEEFQ
FLRCQQCQAEAKCPKLLPCLHTLCSGCLEASGMQ
CPICQAPWPLGADTPALDNVFFESLQRRLSVYR
QIVDAQAVCTRCKESADFWCFECEQLLCAKCFE
AHQWFLKHEARPLAELRNQSVREFLDGTRKTNNI
FCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDS
SHSELKCDISAEIQQRQEELDAMTQALQEQDSA
FGAVHAQMHAAVGQLGRARAETEELIRERVRQVV
AHVRAQERELLEAVDARYQRDYEEMASRLGRLD
AVLQRIRTGSALVQRMKCYASDQEVLDMHGFLR
QALCRLRQEEPQSLQAAVRTDGFDEFKVRLQDLS
SCITQGKDAAVSKKASPEAASTPRDPIDVDLPE
EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVP
VYAFSIKGPSYGEDVSNTTTAQKRKCSQTQCPRK
VIKMESEEGKEARLARSSPEQPRPSTSKAVSPP
HLDGPPSPRSPVIGSEVFLPNSNHVASGAGEAG
RERNALW*SAARKTQMPKTRAWSPWRPPSHSPRQ
PTPRQPTPRQPTPRQSSLC*EHKEPPACPVAHT
TPQLGLPTSPLSRLPPPMLSLTASLLITRSALP
STVGSATCCTEHREPSAFAMPSACTLNCIGPLFG
LGLPMWSKPALLPSQGPSTILPMPRNILPSCKG
ASAHPTGYEGLCDPAAAPSGAPPIYPSGSTTFL
PSPSPPWLPSLTCLPWWGQGKAEPRLLEQVFPLG
TLSEAPWRPLKSKCLWKPLQLHSHHPVPQKGPP
SAQSQAPVKQASESATLLL*PCSQHPCPAPELP
PPAHALTGPAQSSTH*FLVKE*INE*MAMHGPLG
RETWVFSG*EGKAKAWLRFKPPFQASLPKKETS
VTLALSCILSPWPIAQPSMPRPPPQASPLGLCQ
DLSP*AQGLAIPRPGRCGCSINTC*TI

Sequence NM_002675

CTCTCCAGAGGCGGGCCCTGAGCCGGCACCTCCCCTTTCGGACAGCTCAAGGGACTCAGCCAACTGGCTCACGCCTCCCCTTCAGCTTCTCTTCACGCAC
TCCAAGATCTAAACCGAGAATCGAAACTAAGCTGGGGTCCATGGAGCCTGCACCCGCCCGATCTCCGAGGCCCCAGCAGGACCCCGCCCGGCCCCAGGAG
CCCACCATGCCTCCCCCCGAGACCCCCTCTGAAGGCCGCCAGCCCAGCCCCAGCCCCAGCCCTACAGAGCGAGCCCCCGCTTCGGAGGAGGAGTTCCAGT
TTCTGCGCTGCCAGCAATGCCAGGCGGAAGCCAAGTGCCCGAAGCTGCTGCCTTGTCTGCACACGCTGTGCTCAGGATGCCTGGAGGCGTCGGGCATGCA
GTGCCCCATCTGCCAGGCGCCCTGGCCCCTAGGTGCAGACACACCCGCCCTGGATAACGTCTTTTTCGAGAGTCTGCAGCGGCGCCTGTCGGTGTACCGG
CAGATTGTGGATGCGCAGGCTGTGTGCACCCGCTGCAAAGAGTCGGCCGACTTCTGGTGCTTTGAGTGCGAGCAGCTCCTCTGCGCCAAGTGCTTCGAGG
CACACCAGTGGTTCCTCAAGCACGAGGCCCGGCCCCTAGCAGAGCTGCGCAACCAGTCGGTGCGTGAGTTCCTGGACGGCACCCGCAAGACCAACAACAT
CTTCTGCTCCAACCCCAACCACCGCACCCCTACGCTGACCAGCATCTACTGCCGAGGATGTTCCAAGCCGCTGTGCTGCTCGTGCGCGCTCCTTGACAGC
AGCCACAGTGAGCTCAAGTGCGACATCAGCGCAGAGATCCAGCAGCGACAGGAGGAGCTGGACGCCATGACGCAGGCGCTGCAGGAGCAGGATAGTGCCT
TTGGCGCGGTTCACGCGCAGATGCACGCGGCCGTCGGCCAGCTGGGCCGCGCGCGTGCCGAGACCGAGGAGCTGATCCGCGAGCGCGTGCGCCAGGTGGT
AGCTCACGTGCGGGCTCAGGAGCGCGAGCTGCTGGAGGCTGTGGACGCGCGGTACCAGCGCGACTACGAGGAGATGGCCAGTCGGCTGGGCCGCCTGGAT
GCTGTGCTGCAGCGCATCCGCACGGGCAGCGCGCTGGTGCAGAGGATGAAGTGCTACGCCTCGGACCAGGAGGTGCTGGACATGCACGGTTTCCTGCGCC
AGGCGCTCTGCCGCCTGCGCCAGGAGGAGCCCCAGAGCCTGCAAGCTGCCGTGCGCACCGATGGCTTCGACGAGTTCAAGGTGCGCCTGCAGGACCTCAG
CTCTTGCATCACCCAGGGGAAAGATGCAGCTGTATCCAAGAAAGCCAGCCCAGAGGCTGCCAGCACTCCCAGGGACCCTATTGACGTTGACCTGCCCGAG
GAGGCAGAGAGAGTGAAGGCCCAGGTTCAGGCCCTGGGGCTGGCTGAAGCCCAGCCTATGGCTGTGGTACAGTCAGTGCCCGGGGCACACCCCGTGCCAG
TGTACGCCTTCTCCATCAAAGGCCCTTCCTATGGAGAGGATGTCTCCAATACAACGACAGCCCAGAAGAGGAAGTGCAGCCAGACCCAGTGCCCCAGGAA
GGTCATCAAGATGGAGTCTGAGGAGGGGAAGGAGGCAAGGTTGGCTCGGAGCTCCCCGGAGCAGCCCAGGCCCAGCACCTCCAAGGCAGTCTCACCACCC
CACCTGGATGGACCGCCTAGCCCCAGGAGCCCCGTCATAGGAAGTGAGGTCTTCCTGCCCAACAGCAACCACGTGGCCAGTGGCGCCGGGGAGGCAGAGG
AACGCGTTGTGGTGATCAGCAGCTCGGAAGACTCAGATGCCGAAAACTCGTCCTCCCGAGAGCTGGATGACAGCAGCAGTGAGTCCAGTGACCTCCAGCT
GGAAGGCCCCAGCACCCTCAGGGTCCTGGACGAGAACCTTGCTGACCCCCAAGCAGAAGACAGACCTCTGGTTTTCTTTGACCTCAAGATTGACAATGAA
AGTGGGTTCTCCTGGGGCTACCCCCACCCCTTTCTAATTTAGTCTCTGAGTCCCAAAAAGAAGTGCAGGCAGAGCCATCTGCCAGGCCCAGGAGAGCTCT
GAGCTCTGGCCAACAACTGCAGCCAGGCTGGGCAGAGCACTCCGGCTCACCTGGGCTCCTGGCGTGTCATTTGCTGGCTTGAATAAAGATGTCCGCCTTA
TCCAGTGCCTGAGTGTGCGAGAGAGGCAGATGCCTCCA
  • refseq_PML.F2 (forward primer)
  • refseq_PML.R2 (reverse primer)
  • Single exon skipping

Frame 0

LSRGGP*AGTSPFGQLKGLSQLAHASPSASLHA
LQDLNRESKLSWGPWSLHPPDLRGPSRTPPGPRS
PPCLPPRPPLKAASPAPAPALQSEPPLRRRSSS
FCAASNARRKPSARSCCLVCTRCAQDAWRRRAC
SAPSARRPGP*VQTHPPWITSFSRVCSGACRCTG
RLWMRRLCAPAAKSRPTSGALSASSSSAPSASR
HTSGSSSTRPGP*QSCATSRCVSSWTAPARPTT
SSAPTPTTAPLR*PASTAEDVPSRCAARARSLTA
ATVSSSATSAQRSSSDRRSWTP*RRRCRSRIVP
LARFTRRCTRPSASWAARVPRPRS*SASACARW
*LTCGLRSASCWRLWTRGTSATTRRWPVGWAAWM
LCCSASARAARWCRG*SATPRTRRCWTCTVSCA
RRSAACARRSPRACKLPCAPMASTSSRCACRTS
ALASPRGKMQLYPRKPAQRLPALPGTLLTLTCPR
RQRE*RPRFRPWGWLKPSLWLWYSQCPGHTPCQ
CTPSPSKALPMERMSPIQRQPRRGSAARPSAPG
RSSRWSLRRGRRQGWLGAPRSSPGPAPPRQSHHP
TWMDRLAPGAPS*EVRSSCPTATTWPVAPGRQR
NALW*SAARKTQMPKTRPPESWMTAAVSPVTSS
WKAPAPSGSWTRTLLTPKQKTDLWFSLTSRLTMK
VGSPGATPTPF*FSL*VPKRSAGRAICQAQESS
ELWPTTAARLGRALRLTWAPGVSFAGLNKDVRL
IQCLSVRERQMPP

Frame 1

SPEAGPEPAPPLSDSSRDSANWLTPPLQLLFTH
SKI*TENRN*AGVHGACTRPISEAPAGPRPAPG
AHHASPRDPL*RPPAQPQPQPYRASPRFGGGVPV
SALPAMPGGSQVPEAAALSAHAVLRMPGGVGHA
VPHLPGALAPRCRHTRPG*RLFRESAAAPVGVP
ADCGCAGCVHPLQRVGRLLVL*VRAAPLRQVLRG
TPVVPQARGPAPSRAAQPVGA*VPGRHPQDQQH
LLLQPQPPHPYADQHLLPRMFQAAVLLVRAP*Q
QPQ*AQVRHQRRDPAATGGAGRHDAGAAGAG*CL
WRGSRADARGRRPAGPRACRDRGADPRARAPGG
SSRAGSGARAAGGCGRAVPARLRGDGQSAGPPG
CCAAAHPHGQRAGAEDEVLRLGPGGAGHARFPAP
GALPPAPGGAPEPASCRAHRWLRRVQGAPAGPQ
LLHHPGERCSCIQESQPRGCQHSQGPY*R*PAR
GGRESEGPGSGPGAG*SPAYGCGTVSARGTPRAS
VRLLHQRPFLWRGCLQYNDSPEEEVQPDPVPQE
GHQDGV*GGEGGKVGSELPGAAQAQHLQGSLTT
PPGWTA*PQEPRHRK*GLPAQQQPRGQWRRGGRG
TRCGDQQLGRLRCRKLVLPRAG*QQQ*VQ*PPA
GRPQHPQGPGREPC*PPSRRQTSGFL*PQD*Q*
KWVLLGLPPPLSNLVSESQKEVQAEPSARPRRAL
SSGQQLQPGWAEHSGSPGLLACHLLA*IKMSAL
SSA*VCERGRCL

Frame 2

LQRRALSRHLPFRTAQGTQPTGSRLPFSFSSRT
PRSKPRIETKLGSMEPAPARSPRPQQDPARPQE
PTMPPPETPSEGRQPSPSPSPTERAPASEEEFQ
FLRCQQCQAEAKCPKLLPCLHTLCSGCLEASGMQ
CPICQAPWPLGADTPALDNVFFESLQRRLSVYR
QIVDAQAVCTRCKESADFWCFECEQLLCAKCFE
AHQWFLKHEARPLAELRNQSVREFLDGTRKTNNI
FCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDS
SHSELKCDISAEIQQRQEELDAMTQALQEQDSA
FGAVHAQMHAAVGQLGRARAETEELIRERVRQVV
AHVRAQERELLEAVDARYQRDYEEMASRLGRLD
AVLQRIRTGSALVQRMKCYASDQEVLDMHGFLR
QALCRLRQEEPQSLQAAVRTDGFDEFKVRLQDLS
SCITQGKDAAVSKKASPEAASTPRDPIDVDLPE
EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVP
VYAFSIKGPSYGEDVSNTTTAQKRKCSQTQCPRK
VIKMESEEGKEARLARSSPEQPRPSTSKAVSPP
HLDGPPSPRSPVIGSEVFLPNSNHVASGAGEAE
ERVVVISSSEDSDAENSSSRELDDSSSESSDLQL
EGPSTLRVLDENLADPQAEDRPLVFFDLKIDNE
SGFSWGYPHPFLI*SLSPKKKCRQSHLPGPGEL
*ALANNCSQAGQSTPAHLGSWRVICWLE*RCPPY
PVPECAREADAS

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