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Sequences

Sequence NM_030670

AAGTAAAAAAATGGAAGGGGGAAAAGGCAAAGTATTCTGCCTTCCAAGTTAGATAGCTATCTTTATGAAAGGACATATTTCAAAGGCAATATAAAGTCTT TATGGTGCTCTTACCTACCTATATTTGAATTGGGGGATGCTTCACCTGCTTATTAGTGAAAGAAGAAAGAATACACTTAGTAAATTAAATTTTTTTTAAA ACTTTGTCTTTGCTCAGAACCAGCTCCACCCAAATCACTCTTCGCAGTGAACAAAACCCAGACTTCAGTGACTTTGCTGTGGGTGGAAGAGGGAGTAGCT GATTTCTTTGAAGTTTTCTGTCAACAAGTTGGCTCCAGTCAGAAAACCAAACTTCAGGAACCAGTTGCTGTTTCTTCCCATGTCGTGACCATCTCCAGCC TTCTTCCTGCCACTGCCTACAATTGTAGTGTCACCAGCTTTAGCCATGACAGCCCCAGTGTCCCTACGTTCATAGCCGTCTCAACAATGGTTACAGAGAT GAATCCCAATGTGGTAGTGATCTCCGTGCTGGCCATCCTTAGCACACTTTTAATTGGACTGTTGCTTGTTACCCTCATTATTCTTAGGAAAAAGCATCTG CAGATGGCTAGGGAGTGTGGAGCTGGTACATTTGTCAATTTTGCATCCTTAGAGAGGGATGGAAAGCTTCCATACAACTGGAGTAAAAATGGTTTAAAGA AGAGGAAACTGACAAACCCGGTTCAACTGGATGACTTTGATGCCTATATTAAGGATATGGCCAAAGACTCTGACTATAAATTTTCTCTTCAGTTTGAGGA GTTGAAATTGATTGGACTGGATATCCCACACTTTGCTGCAGATCTTCCACTGAATCGATGTAAAAACCGTTACACAAACATCCTACCATATGACTTCAGC CGTGTGAGATTAGTCTCCATGAATGAAGAGGAAGGTGCAGACTACATCAATGCCAACTATATTCCTGGATACAACTCACCCCAGGAGTATATTGCCACCC AGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAG GGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCC TGTAGACACTTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAATGCTG CAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGG AACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCT ATGGTACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACG AGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAGTAAGTGGAGAAGAGCTCTCCACGAGTGCTCAGTCTTAGAACTATTAGAGGGGGATGTGATGGA TGGGACAAAAGACAGCAGTAGCCATTTGTATTGACTCTGACTTCACATGAGTATTTCTTCCCAGCTCCTGGCCTCACATGGGTGGTCACAGGGAGAAACA AGTACTGTAGCAGATCTTTGAGTTTCAATGCACCTTGGTTGGTGTTGGCAACAAACAGGAGCTTCTGCACATCATGATGACTTTACCTCCATTCCCTCTA CCCAGAACCCTAAATTATTCTGTTATTGGATCTGTGCCTGTAATATCAGGATACTACCATCCAAATCTATCTAGATATCTTGTGCAAATATTTTATTGAT TACAAGGGCTGTATACGGGGTTACAAAAAGACATGAGCTGGATTGGACACTCCTAAAACCAAAAACAACAGTGACAATAGAGTCTCAGGATAGCAGAGTC TGAAAATACCTTGGTCTCCCCCATTATGTGAGCCCTTACTTGAGAGCTTCATGAAGACACTTGTAACATATTCAACGTCCTGTACTCCAGTTTTGACTAC GAGATCAGATTTTGGAGGTGTAAGTAAACTTGGCTGAGGTAACAGTAATCTGCCCATTTAGTTCAGTAAACAGACTGTAGAGTGTCTGACTATACTGGGG GAAGAGGAGCCAATGACAGGGTAGGGAGATGACAGTGGTGCATGATGGGAGAATCATGAAAGTCTGGGAAGCATATGGACCAGTGGGAAGGATAGGATTA GCACTGCACCTCTACATCCATCAAGAGAGACAGAGCGCACAATGGAGCAGGAAGGATAAAAAATAAAGAAAGACAGAGAGAAACAAATTTGCTGGGAGAG GGAAAGACATTCAGACCCACAGAAAGGAGGCAGCACACAGAGAAAGATGCACAGATCAACCCACATCTGCATGGGTTGTGAGACTGAGCATAGTGAGAGC AGTGGTGGAGCAATAGAAGATTGCTGTGACACCAGGCTGCTTACTGTCTTTCTTTGTCTCATTCACAGGAGAGGACATGATGTGCGCCCATCCTCCCTTG CTTCCAGATTGTTTTAGTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACC GGGAAGACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCA AGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCA GTGCAATAATTTTTGTGTGTGTGTGATTCTTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATT GTTAGCATCAGATTATACCTCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACT CCAACATTACCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCA GCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGA CTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGG TGCCTAGACTTTGCATTCCTTGTTCTGTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCA AAGAGCTGGGAATTTATGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGAT TCTGACAGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATT ACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGT GATGACATGGATATACAACAGAAAACACTTTGAGTTGAAAGTAAACACAAGCTGGCTGCTTCCCTGTGGCAACTGTGGCT

refseq_PTPRO.F2 (forward primer)
refseq_PTPRO.R2 (reverse primer)
Single exon skipping

Frame 0

K*KNGRGKRQSILPSKLDSYLYERTYFKGNIKS LWCSYLPIFELGDASPAY**KKKEYT**IKFFLK LCLCSEPAPPKSLFAVNKTQTSVTLLWVEEGVA DFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISS LLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEM NPNVVVISVLAILSTLLIGLLLVTLIILRKKHL QMARECGAGTFVNFASLERDGKLPYNWSKNGLK KRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEE LKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS RVRLVSMNEEEGADYINANYIPGYNSPQEYIAT QGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRR VKCDHYWPFTEEPIAYGDITVEMISEEEQDDWA CRHFRINYADEMQDVMHFNYTAWPDHGVPTANA AESILQFVHMVRQQATKSKGPMIIHCSAGVGRTG TFIALDRLLQHIRDHEFVDILGLVSEMRSYRMS MVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIY ENVSKS*FRIRSSKWRRALHECSVLELLEGDVMD GTKDSSSHLY*L*LHMSISSQLLASHGWSQGET STVADL*VSMHLGWCWQQTGASAHHDDFTSIPS TQNPKLFCYWICACNIRILPSKSI*ISCANILLI TRAVYGVTKRHELDWTLLKPKTTVTIESQDSRV *KYLGLPHYVSPYLRAS*RHL*HIQRPVLQF*L RDQILEV*VNLAEVTVICPFSSVNRL*SV*LYWG KRSQ*QGREMTVVHDGRIMKVWEAYGPVGRIGL ALHLYIHQERQSAQWSRKDKK*RKTERNKFAGR GKDIQTHRKEAAHRERCTDQPTSAWVVRLSIVRA VVEQ*KIAVTPGCLLSFFVSFTGEDMMCAHPPL LPDCFSGP*WSFF*TEALLCNMWPRR*FISQKH REDLALKSLQCPFGLFHFGTFNNGPNSTEHQEGQ DALQRAGSTALPKSLVGPLLVGLSFLFLSVCFS VQ*FLCVCDSYQKVELFSAYTVHQPHNPGRNRH C*HQIIPHY*KEAWPHMKKWSFYFKEIEPALSVL QHYRIWIGEVGQGREGFYPQINCVIFYYSSYNS ASK*SRKKIVLTVLVLDGFLPY*QLVFLPWPFW TNVTVQVLSQETTSGSEECQVGLFELCCCLSNRG A*TLHSLFC*PAYM*ELFL*ELYRL*KRTFFPP KSWEFMKLWQ*TAACWDNYLTTFFCNIVKCLYG F*QRFLFVLLFFWLSVSF*RV*LVTFYSLDFV*L QYMIVYCDMNAVKMTLMAL*SLLLCVTS**IRG DDMDIQQKTL*VESKHKLAASLWQLW

Frame 1

SKKMEGGKGKVFCLPS*IAIFMKGHISKAI*SL YGALTYLYLNWGMLHLLISERRKNTLSKLNFF* NFVFAQNQLHPNHSSQ*TKPRLQ*LCCGWKRE*L ISLKFSVNKLAPVRKPNFRNQLLFLPMS*PSPA FFLPLPTIVVSPALAMTAPVSLRS*PSQQWLQR *IPMW**SPCWPSLAHF*LDCCLLPSLFLGKSIC RWLGSVELVHLSILHP*RGMESFHTTGVKMV*R RGN*QTRFNWMTLMPILRIWPKTLTINFLFSLR S*N*LDWISHTLLQIFH*IDVKTVTQTSYHMTSA V*D*SP*MKRKVQTTSMPTIFLDTTHPRSILPP RGHCLKPEMTSGRWSCNKSLRLLSCSLSVMRKG G*NVTITGHSRKNL*PMETSLWR*FQRKSRTTGP VDTSGSTMLTRCRM*CILTTLHGLIMVCPQQML QKVSCSLYTWSDSKLPRAKVP*SFTAVLAWDGQ EHSLPWTGSCSTFGIMSLLTS*GWCQK*GHTGCL WYRQRSSTFLSISVCN*CG*RRSSSSASVMSYT RMLASPSSESGAVSGEELSTSAQS*NY*RGM*W MGQKTAVAICIDSDFT*VFLPSSWPHMGGHREKQ VL*QIFEFQCTLVGVGNKQELLHIMMTLPPFPL PRTLNYSVIGSVPVISGYYHPNLSRYLVQIFY* LQGLYTGLQKDMSWIGHS*NQKQQ*Q*SLRIAES ENTLVSPIM*ALT*ELHEDTCNIFNVLYSSFDY EIRFWRCK*TWLR*Q*SAHLVQ*TDCRVSDYTG GRGANDRVGR*QWCMMGES*KSGKHMDQWEG*D* HCTSTSIKRDRAHNGAGRIKNKERQRETNLLGE GKTFRPTERRQHTEKDAQINPHLHGL*D*A**E QWWSNRRLL*HQAAYCLSLSHSQERT*CAPILPC FQIVLVGPDGHFSKQRPCFVICGQGDNLSHRST GKT*P*RAYSVLLDSFTSGHLIMDQIQQNTRKV KTLSKGQEVQHFRRV*LALCWLG*VFYF*VFVFQ CNNFCVCVILIRKLNCFLPTPFISPITQEGTGI VSIRLYLIIKRRHGHT*RNGHSTSKKLSQHYLY SNITGSGLGRLVREERGSTHRSTV*SFTIQAIIQ LQSRVEKKLS*LF*FLMVFFLINSWCFFLGPFG LMLLSKFFLKKPHLVQKSVKLDSLNSVAV*AIV VPRLCIPCSVDLHTCESYFFKNYIGCENALSFPQ RAGNL*SYGNELQHAGTII*LLFFVILSNVSMD SDRDFFLFCYSFGCQFHFNECN**HFILWILYN YST*LCIVT*MLSK*H*WHCEACYFVSLPDK*EV MTWIYNRKHFELKVNTSWLLPCGNCG

Frame 2

VKKWKGEKAKYSAFQVR*LSL*KDIFQRQYKVF MVLLPTYI*IGGCFTCLLVKEERIHLVN*IFFK TLSLLRTSSTQITLRSEQNPDFSDFAVGGRGSS *FL*SFLSTSWLQSENQTSGTSCCFFPCRDHLQP SSCHCLQL*CHQL*P*QPQCPYVHSRLNNGYRD ESQCGSDLRAGHP*HTFNWTVACYPHYS*EKAS ADG*GVWSWYICQFCILREGWKASIQLE*KWFKE EETDKPGSTG*L*CLY*GYGQRL*L*IFSSV*G VEIDWTGYPTLCCRSSTESM*KPLHKHPTI*LQ PCEISLHE*RGRCRLHQCQLYSWIQLTPGVYCHP GATA*NQK*LLEDGPATKVSDYCHAHSV**EKE GEM*PLLAIHGRTYSLWRHHCGDDFRGRAGRLG L*TLPDQLC*RDAGCDAF*LHCMA*SWCAHSKCC RKYPAVCTHGPTASYQEQRSHDHSLQCWRGTDR NIHCPGQALAAHSGS*VC*HLRAGVRNEVIPDV YGTDRGAVHFYPSVCATDVDEEEAAVLHQ*CHIR EC*QVLVQNPEQ*VEKSSPRVLSLRTIRGGCDG WDKRQQ*PFVLTLTSHEYFFPAPGLTWVVTGRN KYCSRSLSFNAPWLVLATNRSFCTS**LYLHSLY PEP*IILLLDLCL*YQDTTIQIYLDILCKYFID YKGCIRGYKKT*AGLDTPKTKNNSDNRVSG*QS LKIPWSPPLCEPLLESFMKTLVTYSTSCTPVLTT RSDFGGVSKLG*GNSNLPI*FSKQTVECLTILG EEEPMTG*GDDSGA*WENHESLGSIWTSGKDRI STAPLHPSRETERTMEQEG*KIKKDREKQICWER ERHSDPQKGGSTQRKMHRSTHICMGCETEHSES SGGAIEDCCDTRLLTVFLCLIHRRGHDVRPSSL ASRLF*WALMVIFLNRGPAL*YVAKEIIYLTEAP GRLSLKEPTVSFWTLSLRDI**WTKFNRTPGRS RRSPKGRKYSTSEEFSWPFAGWAEFFIFKCLFF SAIIFVCV*FLSES*IVFCLHRSSAP*PRKEQAL LASDYTSLLKGGMATHEEMVILLQRN*ASTICT PTLPDLDWGGWSGKRGVLPTDQLCNLLLFKL*F SFKVE*KKNCLNCSSS*WFSSLLTVGVSSLALLD *CYCPSSFSRNHIWFRRVSSWTL*TLLLSEQSW CLDFAFLVLLTCIHVRAISLRTI*AVKTHFLSP KELGIYEVMAMNCSMLGQLFDYFFL*YCQMSLWI LTEISFCFVILLVVSFILTSVTSNILFFGFCII TVHDCVL*HECCQNDIDGIVKPVTLCHFLINKR **HGYTTENTLS*K*TQAGCFPVATVA

Sequence NM_002848

GGGCGCAGAGGAGGAAAGGGAGCAGGCGCAGGGGGACTGGAAAGGCAGCATGCGCTCGCCAGGAGCAACCTCGGCGCCCAGGGTCTGAGGCTGCAGCCCC AGTTCGCCATTGTGAGCCGCCGCCGGGGGAGTCCGCTAGCGCAGCCGTGCCCCCGAGTCCCCGTCCGCGCAGCGATGGGGCACCTGCCCACGGGGATACA CGGCGCCCGCCGCCTCCTGCCTCTGCTCTGGCTCTTTGTGCTGTTCAAGAATGCTACAGCTTTCCATGTAACTGTCCAAGATGATAATAACATCGTTGTC TCATTAGAAGCTTCAGACGTCATCAGTCCAGCATCTGTGTATGTTGTGAAGATAACTGGTGAATCCAAAAATTATTTCTTCGAATTTGAGGAATTCAACA GCACTTTGCCTCCTCCTGTTATTTTCAAGGCCAGTTATCATGGCCTTTATTATATAATCACTCTGGTAGTGGTAAATGGAAATGTGGTGACCAAGCCATC CAGATCAATCACTGTGTTAACAAAACCTCTACCTGTAACCAGTGTTTCCATATATGACTATAAACCTTCTCCTGAAACAGGAGTCCTGTTTGAAATACAT TATCCAGAAAAATATAACGTTTTCACAAGAGTGAACATTAGCTACTGGGAAGGTAAAGACTTCCGGACAATGCTATATAAAGATTTCTTTAAGGGAAAAA CAGTATTTAATCACTGGCTGCCAGGAATGTGTTATAGTAATATCACCTTTCAGCTGGTATCTGAGGCAACTTTTAATAAAAGTACCCTTGTTGAGTACAG TGGTGTCAGTCACGAACCCAAACAGCACAGAACTGCCCCTTATCCACCTCAAAATATTTCCGTTCGTATCGTAAACTTGAACAAAAACAACTGGGAAGAA CAGAGTGGCAATTTCCCAGAAGAATCCTTCATGAGATCACAAGATACAATAGGAAAAGAAAAACTCTTCCATTTTACAGAAGAAACCCCTGAAATTCCCT CGGGCAACATTTCTTCCGGTTGGCCTGATTTTAATAGCAGTGACTATGAAACTACGTCTCAGCCATATTGGTGGGACAGTGCATCTGCAGCTCCTGAAAG TGAAGATGAATTTGTCAGCGTACTTCCCATGGAATACGAAAATAACAGTACACTCAGTGAGACAGAGAAGTCAACATCAGGCTCTTTCTCCTTTTTCCCT GTGCAAATGATATTGACCTGGTTACCACCCAAACCACCCACTGCTTTTGATGGGTTCCATATCCATATTGAACGAGAAGAGAACTTTACTGAATATTTGA TGGTGGATGAAGAAGCACATGAATTTGTTGCAGAACTGAAGGAACCTGGGAAATATAAGTTATCTGTGACAACCTTTAGTTCCTCAGGATCTTGTGAAAC TCGAAAAAGTCAGTCAGCAAAATCACTCAGCTTTTATATCAGTCCTTCAGGAGAGTGGATTGAAGAACTGACCGAGAAGCCGCAGCACGTGAGTGTCCAC GTTTTAAGCTCAACCACTGCCTTGATGTCCTGGACATCTTCCCAAGAGAACTACAACAGCACCATTGTGTCTGTGGTGTCGCTGACCTGCCAGAAACAAA AGGAGAGCCAGAGGCTTGAAAAGCAGTACTGCACTCAGGTGAACTCAAGCAAACCTATTATTGAAAATCTGGTTCCTGGTGCCCAGTACCAGGTTGTAAT ATACCTAAGGAAAGGCCCTTTGATTGGACCACCTTCAGATCCTGTGACATTTGCTATTGTTCCCACAGGAATAAAGGATTTAATGCTCTATCCTTTGGGT CCTACGGCCGTGGTTCTGAGCTGGACCAGACCTTATTTAGGCGTGTTCAGAAAATACGTGGTTGAAATGTTTTATTTCAACCCTGCTACAATGACATCAG AGTGGACCACCTACTATGAAATAGCAGCAACTGTTTCCTTAACTGCATCCGTGAGAATAGCTAATCTGCTGCCAGCATGGTACTACAACTTCCGGGTTAC CATGGTGACGTGGGGAGATCCAGAATTGAGCTGCTGTGACAGCTCTACCATCAGCTTCATAACAGCCCCAGTGGCTCCGGAAATCACTTCTGTGGAATAT TTCAACAGTCTGTTATATATCAGTTGGACATATGGGGATGATACAACGGACTTGTCCCATTCTAGAATGCTTCACTGGATGGTGGTTGCAGAAGGAAAAA AGAAAATTAAAAAGAGTGTAACACGCAATGTCATGACTGCAATTCTCAGCTTGCCTCCAGGCGACATCTATAACCTCTCAGTAACTGCTTGTACTGAAAG AGGAAGTAATACCTCCATGCTCCGCCTTGTCAAGCTAGAACCAGCTCCACCCAAATCACTCTTCGCAGTGAACAAAACCCAGACTTCAGTGACTTTGCTG TGGGTGGAAGAGGGAGTAGCTGATTTCTTTGAAGTTTTCTGTCAACAAGTTGGCTCCAGTCAGAAAACCAAACTTCAGGAACCAGTTGCTGTTTCTTCCC ATGTCGTGACCATCTCCAGCCTTCTTCCTGCCACTGCCTACAATTGTAGTGTCACCAGCTTTAGCCATGACAGCCCCAGTGTCCCTACGTTCATAGCCGT CTCAACAATGGTTACAGAGATGAATCCCAATGTGGTAGTGATCTCCGTGCTGGCCATCCTTAGCACACTTTTAATTGGACTGTTGCTTGTTACCCTCATT ATTCTTAGGAAAAAGCATCTGCAGATGGCTAGGGAGTGTGGAGCTGGTACATTTGTCAATTTTGCATCCTTAGAGAGGGATGGAAAGCTTCCATACAACT GGAGTAAAAATGGTTTAAAGAAGAGGAAACTGACAAACCCGGTTCAACTGGATGACTTTGATGCCTATATTAAGGATATGGCCAAAGACTCTGACTATAA ATTTTCTCTTCAGTTTGAGGAGTTGAAATTGATTGGACTGGATATCCCACACTTTGCTGCAGATCTTCCACTGAATCGATGTAAAAACCGTTACACAAAC ATCCTACCATATGACTTCAGCCGTGTGAGATTAGTCTCCATGAATGAAGAGGAAGGTGCAGACTACATCAATGCCAACTATATTCCTGGATACAACTCAC CCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCAC TCAGTGTAATGAGAAAAGGAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAG GAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATG GTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAG TGCTGGCGTGGGACGGACAGGAACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAA ATGAGGTCATACCGGATGTCTATGGTACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCT GCATCAGTGATGTCATATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTG TTTTAGTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTA GCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCC AAAGGGCAGGAAGTACAGCACTTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATT TTTGTGTGTGTGTGATTCTTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAG ATTATACCTCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACC GGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTA GAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACT GTCCAAGTTCTTTCTCAAGAAACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTT TGCATTCCTTGTTCTGTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGA ATTTATGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGA TTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGA TTGTGTATTGTGACATGAATGCTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGA TATACAACAGAAAACACTTTGAGTTGAAAGTAAACACAAGCTGGCTGCTTCCCTGTGGCAACTGTGGCT

refseq_PTPRO.F2 (forward primer)
refseq_PTPRO.R2 (reverse primer)
Single exon skipping

Frame 0

GRRGGKGAGAGGLERQHALARSNLGAQGLRLQP QFAIVSRRRGSPLAQPCPRVPVRAAMGHLPTGIH GARRLLPLLWLFVLFKNATAFHVTVQDDNNIVV SLEASDVISPASVYVVKITGESKNYFFEFEEFN STLPPPVIFKASYHGLYYIITLVVVNGNVVTKPS RSITVLTKPLPVTSVSIYDYKPSPETGVLFEIH YPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGK TVFNHWLPGMCYSNITFQLVSEATFNKSTLVEYS GVSHEPKQHRTAPYPPQNISVRIVNLNKNNWEE QSGNFPEESFMRSQDTIGKEKLFHFTEETPEIP SGNISSGWPDFNSSDYETTSQPYWWDSASAAPES EDEFVSVLPMEYENNSTLSETEKSTSGSFSFFP VQMILTWLPPKPPTAFDGFHIHIEREENFTEYL MVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCET RKSQSAKSLSFYISPSGEWIEELTEKPQHVSVH VLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQ KESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVI YLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLG PTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTS EWTTYYEIAATVSLTASVRIANLLPAWYYNFRVT MVTWGDPELSCCDSSTISFITAPVAPEITSVEY FNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGK KKIKKSVTRNVMTAILSLPPGDIYNLSVTACTER GSNTSMLRLVKLEPAPPKSLFAVNKTQTSVTLL WVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSS HVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAV STMVTEMNPNVVVISVLAILSTLLIGLLLVTLI ILRKKHLQMARECGAGTFVNFASLERDGKLPYN WSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYK FSLQFEELKLIGLDIPHFAADLPLNRCKNRYTN ILPYDFSRVRLVSMNEEEGADYINANYIPGYNS PQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISE EEQDDWACRHFRINYADEMQDVMHFNYTAWPDH GVPTANAAESILQFVHMVRQQATKSKGPMIIHCS AGVGRTGTFIALDRLLQHIRDHEFVDILGLVSE MRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQF CISDVIYENVSKS*FRIRSREDMMCAHPPLLPDC FSGP*WSFF*TEALLCNMWPRR*FISQKHREDL ALKSLQCPFGLFHFGTFNNGPNSTEHQEGQDAL QRAGSTALPKSLVGPLLVGLSFLFLSVCFSVQ*F LCVCDSYQKVELFSAYTVHQPHNPGRNRHC*HQ IIPHY*KEAWPHMKKWSFYFKEIEPALSVLQHY RIWIGEVGQGREGFYPQINCVIFYYSSYNSASK* SRKKIVLTVLVLDGFLPY*QLVFLPWPFWTNVT VQVLSQETTSGSEECQVGLFELCCCLSNRGA*T LHSLFC*PAYM*ELFL*ELYRL*KRTFFPPKSWE FMKLWQ*TAACWDNYLTTFFCNIVKCLYGF*QR FLFVLLFFWLSVSF*RV*LVTFYSLDFV*LQYM IVYCDMNAVKMTLMAL*SLLLCVTS**IRGDDMD IQQKTL*VESKHKLAASLWQLW

Frame 1

GAEEEREQAQGDWKGSMRSPGATSAPRV*GCSP SSPL*AAAGGVR*RSRAPESPSAQRWGTCPRGY TAPAASCLCSGSLCCSRMLQLSM*LSKMIITSLS H*KLQTSSVQHLCML*R*LVNPKIISSNLRNST ALCLLLLFSRPVIMAFII*SLW*W*MEMW*PSH PDQSLC*QNLYL*PVFPYMTINLLLKQESCLKYI IQKNITFSQE*TLATGKVKTSGQCYIKISLREK QYLITGCQECVIVISPFSWYLRQLLIKVPLLST VVSVTNPNSTELPLIHLKIFPFVS*T*TKTTGKN RVAISQKNPS*DHKIQ*EKKNSSILQKKPLKFP RATFLPVGLILIAVTMKLRLSHIGGTVHLQLLK VKMNLSAYFPWNTKITVHSVRQRSQHQALSPFSL CK*Y*PGYHPNHPLLLMGSISILNEKRTLLNI* WWMKKHMNLLQN*RNLGNISYL*QPLVPQDLVK LEKVSQQNHSAFISVLQESGLKN*PRSRST*VST F*AQPLP*CPGHLPKRTTTAPLCLWCR*PARNK RRARGLKSSTALR*TQANLLLKIWFLVPSTRL* YT*GKAL*LDHLQIL*HLLLFPQE*RI*CSILWV LRPWF*AGPDLI*ACSENTWLKCFISTLLQ*HQ SGPPTMK*QQLFP*LHP*E*LICCQHGTTTSGL PW*RGEIQN*AAVTALPSAS*QPQWLRKSLLWNI STVCYISVGHMGMIQRTCPILECFTGWWLQKEK RKLKRV*HAMS*LQFSACLQATSITSQ*LLVLK EEVIPPCSALSS*NQLHPNHSSQ*TKPRLQ*LCC GWKRE*LISLKFSVNKLAPVRKPNFRNQLLFLP MS*PSPAFFLPLPTIVVSPALAMTAPVSLRS*P SQQWLQR*IPMW**SPCWPSLAHF*LDCCLLPSL FLGKSICRWLGSVELVHLSILHP*RGMESFHTT GVKMV*RRGN*QTRFNWMTLMPILRIWPKTLTI NFLFSLRS*N*LDWISHTLLQIFH*IDVKTVTQT SYHMTSAV*D*SP*MKRKVQTTSMPTIFLDTTH PRSILPPRGHCLKPEMTSGRWSCNKSLRLLSCS LSVMRKGG*NVTITGHSRKNL*PMETSLWR*FQR KSRTTGPVDTSGSTMLTRCRM*CILTTLHGLIM VCPQQMLQKVSCSLYTWSDSKLPRAKVP*SFTA VLAWDGQEHSLPWTGSCSTFGIMSLLTS*GWCQK *GHTGCLWYRQRSSTFLSISVCN*CG*RRSSSS ASVMSYTRMLASPSSESGAERT*CAPILPCFQI VLVGPDGHFSKQRPCFVICGQGDNLSHRSTGKT* P*RAYSVLLDSFTSGHLIMDQIQQNTRKVKTLS KGQEVQHFRRV*LALCWLG*VFYF*VFVFQCNN FCVCVILIRKLNCFLPTPFISPITQEGTGIVSIR LYLIIKRRHGHT*RNGHSTSKKLSQHYLYSNIT GSGLGRLVREERGSTHRSTV*SFTIQAIIQLQS RVEKKLS*LF*FLMVFFLINSWCFFLGPFGLMLL SKFFLKKPHLVQKSVKLDSLNSVAV*AIVVPRL CIPCSVDLHTCESYFFKNYIGCENALSFPQRAG NL*SYGNELQHAGTII*LLFFVILSNVSMDSDRD FFLFCYSFGCQFHFNECN**HFILWILYNYST* LCIVT*MLSK*H*WHCEACYFVSLPDK*EVMTW IYNRKHFELKVNTSWLLPCGNCG

Frame 2

AQRRKGSRRRGTGKAACARQEQPRRPGSEAAAP VRHCEPPPGESASAAVPPSPRPRSDGAPAHGDT RRPPPPASALALCAVQECYSFPCNCPR***HRC LIRSFRRHQSSICVCCEDNW*IQKLFLRI*GIQQ HFASSCYFQGQLSWPLLYNHSGSGKWKCGDQAI QINHCVNKTSTCNQCFHI*L*TFS*NRSPV*NT LSRKI*RFHKSEH*LLGR*RLPDNAI*RFL*GKN SI*SLAARNVL**YHLSAGI*GNF**KYPC*VQ WCQSRTQTAQNCPLSTSKYFRSYRKLEQKQLGR TEWQFPRRILHEITRYNRKRKTLPFYRRNP*NSL GQHFFRLA*F**Q*L*NYVSAILVGQCICSS*K *R*ICQRTSHGIRK*QYTQ*DREVNIRLFLLFP CANDIDLVTTQTTHCF*WVPYPY*TRRELY*IFD GG*RST*ICCRTEGTWEI*VICDNL*FLRIL*N SKKSVSKITQLLYQSFRRVD*RTDREAAARECP RFKLNHCLDVLDIFPRELQQHHCVCGVADLPETK GEPEA*KAVLHSGELKQTYY*KSGSWCPVPGCN IPKERPFDWTTFRSCDICYCSHRNKGFNALSFG SYGRGSELDQTLFRRVQKIRG*NVLFQPCYNDIR VDHLL*NSSNCFLNCIRENS*SAASMVLQLPGY HGDVGRSRIELL*QLYHQLHNSPSGSGNHFCGI FQQSVIYQLDIWG*YNGLVPF*NASLDGGCRRKK EN*KECNTQCHDCNSQLASRRHL*PLSNCLY*K RK*YLHAPPCQARTSSTQITLRSEQNPDFSDFA VGGRGSS*FL*SFLSTSWLQSENQTSGTSCCFFP CRDHLQPSSCHCLQL*CHQL*P*QPQCPYVHSR LNNGYRDESQCGSDLRAGHP*HTFNWTVACYPH YS*EKASADG*GVWSWYICQFCILREGWKASIQL E*KWFKEEETDKPGSTG*L*CLY*GYGQRL*L* IFSSV*GVEIDWTGYPTLCCRSSTESM*KPLHK HPTI*LQPCEISLHE*RGRCRLHQCQLYSWIQLT PGVYCHPGATA*NQK*LLEDGPATKVSDYCHAH SV**EKEGEM*PLLAIHGRTYSLWRHHCGDDFR GRAGRLGL*TLPDQLC*RDAGCDAF*LHCMA*SW CAHSKCCRKYPAVCTHGPTASYQEQRSHDHSLQ CWRGTDRNIHCPGQALAAHSGS*VC*HLRAGVR NEVIPDVYGTDRGAVHFYPSVCATDVDEEEAAVL HQ*CHIREC*QVLVQNPEQRGHDVRPSSLASRL F*WALMVIFLNRGPAL*YVAKEIIYLTEAPGRL SLKEPTVSFWTLSLRDI**WTKFNRTPGRSRRSP KGRKYSTSEEFSWPFAGWAEFFIFKCLFFSAII FVCV*FLSES*IVFCLHRSSAP*PRKEQALLAS DYTSLLKGGMATHEEMVILLQRN*ASTICTPTLP DLDWGGWSGKRGVLPTDQLCNLLLFKL*FSFKV E*KKNCLNCSSS*WFSSLLTVGVSSLALLD*CY CPSSFSRNHIWFRRVSSWTL*TLLLSEQSWCLDF AFLVLLTCIHVRAISLRTI*AVKTHFLSPKELG IYEVMAMNCSMLGQLFDYFFL*YCQMSLWILTE ISFCFVILLVVSFILTSVTSNILFFGFCIITVHD CVL*HECCQNDIDGIVKPVTLCHFLINKR**HG YTTENTLS*K*TQAGCFPVATVA

Sequence NM_030668

AAGTAAAAAAATGGAAGGGGGAAAAGGCAAAGTATTCTGCCTTCCAAGTTAGATAGCTATCTTTATGAAAGGACATATTTCAAAGGCAATATAAAGTCTT TATGGTGCTCTTACCTACCTATATTTGAATTGGGGGATGCTTCACCTGCTTATTAGTGAAAGAAGAAAGAATACACTTAGTAAATTAAATTTTTTTTAAA ACTTTGTCTTTGCTCAGAACCAGCTCCACCCAAATCACTCTTCGCAGTGAACAAAACCCAGACTTCAGTGACTTTGCTGTGGGTGGAAGAGGGAGTAGCT GATTTCTTTGAAGTTTTCTGTCAACAAGTTGGCTCCAGTCAGAAAACCAAACTTCAGGAACCAGTTGCTGTTTCTTCCCATGTCGTGACCATCTCCAGCC TTCTTCCTGCCACTGCCTACAATTGTAGTGTCACCAGCTTTAGCCATGACAGCCCCAGTGTCCCTACGTTCATAGCCGTCTCAACAATGGTTACAGAGAT GAATCCCAATGTGGTAGTGATCTCCGTGCTGGCCATCCTTAGCACACTTTTAATTGGACTGTTGCTTGTTACCCTCATTATTCTTAGGAAAAAGCATCTG CAGATGGCTAGGGAGTGTGGAGCTGGTACATTTGTCAATTTTGCATCCTTAGAGAGGGATGGAAAGCTTCCATACAACTGGAGTAAAAATGGTTTAAAGA AGAGGAAACTGACAAACCCGGTTCAACTGGATGACTTTGATGCCTATATTAAGGATATGGCCAAAGACTCTGACTATAAATTTTCTCTTCAGTTTGAGGA GTTGAAATTGATTGGACTGGATATCCCACACTTTGCTGCAGATCTTCCACTGAATCGATGTAAAAACCGTTACACAAACATCCTACCATATGACTTCAGC CGTGTGAGATTAGTCTCCATGAATGAAGAGGAAGGTGCAGACTACATCAATGCCAACTATATTCCTGGATACAACTCACCCCAGGAGTATATTGCCACCC AGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAG GGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCC TGTAGACACTTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAATGCTG CAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGG AACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCT ATGGTACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACG AGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAGTGGGCCCTGATGGTC ATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTAGCCTTAAAGAGCCTACAGTGT CCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCAC TTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTA TCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATTATTAAAAG GAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGATCTGGATTGGGGAGGTTG GTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTT AACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAA ACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTGTTGAC CTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTATGAAGTTATGGCAATG AACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGATTTCTTTTTGTTTTGTTATTC TTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGATTGTGTATTGTGACATGAATG CTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACTTTG AGTTGAAAGTAAACACAAGCTGGCTGCTTCCCTGTGGCAACTGTGGCT

refseq_PTPRO.F2 (forward primer)
refseq_PTPRO.R2 (reverse primer)
Single exon skipping

Frame 0

K*KNGRGKRQSILPSKLDSYLYERTYFKGNIKS LWCSYLPIFELGDASPAY**KKKEYT**IKFFLK LCLCSEPAPPKSLFAVNKTQTSVTLLWVEEGVA DFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISS LLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEM NPNVVVISVLAILSTLLIGLLLVTLIILRKKHL QMARECGAGTFVNFASLERDGKLPYNWSKNGLK KRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEE LKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS RVRLVSMNEEEGADYINANYIPGYNSPQEYIAT QGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRR VKCDHYWPFTEEPIAYGDITVEMISEEEQDDWA CRHFRINYADEMQDVMHFNYTAWPDHGVPTANA AESILQFVHMVRQQATKSKGPMIIHCSAGVGRTG TFIALDRLLQHIRDHEFVDILGLVSEMRSYRMS MVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIY ENVSKS*FRIRSREDMMCAHPPLLPDCFSGP*WS FF*TEALLCNMWPRR*FISQKHREDLALKSLQC PFGLFHFGTFNNGPNSTEHQEGQDALQRAGSTA LPKSLVGPLLVGLSFLFLSVCFSVQ*FLCVCDSY QKVELFSAYTVHQPHNPGRNRHC*HQIIPHY*K EAWPHMKKWSFYFKEIEPALSVLQHYRIWIGEV GQGREGFYPQINCVIFYYSSYNSASK*SRKKIVL TVLVLDGFLPY*QLVFLPWPFWTNVTVQVLSQE TTSGSEECQVGLFELCCCLSNRGA*TLHSLFC* PAYM*ELFL*ELYRL*KRTFFPPKSWEFMKLWQ* TAACWDNYLTTFFCNIVKCLYGF*QRFLFVLLF FWLSVSF*RV*LVTFYSLDFV*LQYMIVYCDMN AVKMTLMAL*SLLLCVTS**IRGDDMDIQQKTL* VESKHKLAASLWQLW

Frame 1

SKKMEGGKGKVFCLPS*IAIFMKGHISKAI*SL YGALTYLYLNWGMLHLLISERRKNTLSKLNFF* NFVFAQNQLHPNHSSQ*TKPRLQ*LCCGWKRE*L ISLKFSVNKLAPVRKPNFRNQLLFLPMS*PSPA FFLPLPTIVVSPALAMTAPVSLRS*PSQQWLQR *IPMW**SPCWPSLAHF*LDCCLLPSLFLGKSIC RWLGSVELVHLSILHP*RGMESFHTTGVKMV*R RGN*QTRFNWMTLMPILRIWPKTLTINFLFSLR S*N*LDWISHTLLQIFH*IDVKTVTQTSYHMTSA V*D*SP*MKRKVQTTSMPTIFLDTTHPRSILPP RGHCLKPEMTSGRWSCNKSLRLLSCSLSVMRKG G*NVTITGHSRKNL*PMETSLWR*FQRKSRTTGP VDTSGSTMLTRCRM*CILTTLHGLIMVCPQQML QKVSCSLYTWSDSKLPRAKVP*SFTAVLAWDGQ EHSLPWTGSCSTFGIMSLLTS*GWCQK*GHTGCL WYRQRSSTFLSISVCN*CG*RRSSSSASVMSYT RMLASPSSESGAERT*CAPILPCFQIVLVGPDG HFSKQRPCFVICGQGDNLSHRSTGKT*P*RAYSV LLDSFTSGHLIMDQIQQNTRKVKTLSKGQEVQH FRRV*LALCWLG*VFYF*VFVFQCNNFCVCVIL IRKLNCFLPTPFISPITQEGTGIVSIRLYLIIKR RHGHT*RNGHSTSKKLSQHYLYSNITGSGLGRL VREERGSTHRSTV*SFTIQAIIQLQSRVEKKLS *LF*FLMVFFLINSWCFFLGPFGLMLLSKFFLKK PHLVQKSVKLDSLNSVAV*AIVVPRLCIPCSVD LHTCESYFFKNYIGCENALSFPQRAGNL*SYGN ELQHAGTII*LLFFVILSNVSMDSDRDFFLFCYS FGCQFHFNECN**HFILWILYNYST*LCIVT*M LSK*H*WHCEACYFVSLPDK*EVMTWIYNRKHF ELKVNTSWLLPCGNCG

Frame 2

VKKWKGEKAKYSAFQVR*LSL*KDIFQRQYKVF MVLLPTYI*IGGCFTCLLVKEERIHLVN*IFFK TLSLLRTSSTQITLRSEQNPDFSDFAVGGRGSS *FL*SFLSTSWLQSENQTSGTSCCFFPCRDHLQP SSCHCLQL*CHQL*P*QPQCPYVHSRLNNGYRD ESQCGSDLRAGHP*HTFNWTVACYPHYS*EKAS ADG*GVWSWYICQFCILREGWKASIQLE*KWFKE EETDKPGSTG*L*CLY*GYGQRL*L*IFSSV*G VEIDWTGYPTLCCRSSTESM*KPLHKHPTI*LQ PCEISLHE*RGRCRLHQCQLYSWIQLTPGVYCHP GATA*NQK*LLEDGPATKVSDYCHAHSV**EKE GEM*PLLAIHGRTYSLWRHHCGDDFRGRAGRLG L*TLPDQLC*RDAGCDAF*LHCMA*SWCAHSKCC RKYPAVCTHGPTASYQEQRSHDHSLQCWRGTDR NIHCPGQALAAHSGS*VC*HLRAGVRNEVIPDV YGTDRGAVHFYPSVCATDVDEEEAAVLHQ*CHIR EC*QVLVQNPEQRGHDVRPSSLASRLF*WALMV IFLNRGPAL*YVAKEIIYLTEAPGRLSLKEPTV SFWTLSLRDI**WTKFNRTPGRSRRSPKGRKYST SEEFSWPFAGWAEFFIFKCLFFSAIIFVCV*FL SES*IVFCLHRSSAP*PRKEQALLASDYTSLLK GGMATHEEMVILLQRN*ASTICTPTLPDLDWGGW SGKRGVLPTDQLCNLLLFKL*FSFKVE*KKNCL NCSSS*WFSSLLTVGVSSLALLD*CYCPSSFSR NHIWFRRVSSWTL*TLLLSEQSWCLDFAFLVLLT CIHVRAISLRTI*AVKTHFLSPKELGIYEVMAM NCSMLGQLFDYFFL*YCQMSLWILTEISFCFVI LLVVSFILTSVTSNILFFGFCIITVHDCVL*HEC CQNDIDGIVKPVTLCHFLINKR**HGYTTENTL S*K*TQAGCFPVATVA

Sequence NM_030669

AAGTAAAAAAATGGAAGGGGGAAAAGGCAAAGTATTCTGCCTTCCAAGTTAGATAGCTATCTTTATGAAAGGACATATTTCAAAGGCAATATAAAGTCTT TATGGTGCTCTTACCTACCTATATTTGAATTGGGGGATGCTTCACCTGCTTATTAGTGAAAGAAGAAAGAATACACTTAGTAAATTAAATTTTTTTTAAA ACTTTGTCTTTGCTCAGAACCAGCTCCACCCAAATCACTCTTCGCAGTGAACAAAACCCAGACTTCAGTGACTTTGCTGTGGGTGGAAGAGGGAGTAGCT GATTTCTTTGAAGTTTTCTGTCAACAAGTTGGCTCCAGTCAGAAAACCAAACTTCAGGAACCAGTTGCTGTTTCTTCCCATGTCGTGACCATCTCCAGCC TTCTTCCTGCCACTGCCTACAATTGTAGTGTCACCAGCTTTAGCCATGACAGCCCCAGTGTCCCTACGTTCATAGCCGTCTCAACAATGGTTACAGAGAT GAATCCCAATGTGGTAGTGATCTCCGTGCTGGCCATCCTTAGCACACTTTTAATTGGACTGTTGCTTGTTACCCTCATTATTCTTAGGAAAAAGCATCTG CAGATGGCTAGGGAGTGTGGAGCTGGTACATTTGTCAATTTTGCATCCTTAGAGAGGGATGGAAAGCTTCCATACAACTGGCGTAGGAGTATATTTGCTT TCTTAACCCTGCTACCCTCATGTCTTTGGACTGATTATCTTTTGGCATTTTATATTAATCCTTGGAGTAAAAATGGTTTAAAGAAGAGGAAACTGACAAA CCCGGTTCAACTGGATGACTTTGATGCCTATATTAAGGATATGGCCAAAGACTCTGACTATAAATTTTCTCTTCAGTTTGAGGAGTTGAAATTGATTGGA CTGGATATCCCACACTTTGCTGCAGATCTTCCACTGAATCGATGTAAAAACCGTTACACAAACATCCTACCATATGACTTCAGCCGTGTGAGATTAGTCT CCATGAATGAAGAGGAAGGTGCAGACTACATCAATGCCAACTATATTCCTGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGA AACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAGGGTGAAATGTGACCAT TACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGA TCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCA GTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCCTG GACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGGTACAGACAGAGG AGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTC CTAGTTCAGAATCCGGAGCAGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAGTGGGCCCTGATGGTCATTTTTCTAAACAGAG GCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTC ACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTTTAGT TGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATCAGAAAGTTGAATTG TTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATTATTAAAAGGAGGCATGGCCACACA TGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGG GTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCTT GATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCACATCTGGTTCAG AAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTGTTGACCTGCATACATGTGAGA GCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTATGAAGTTATGGCAATGAACTGCAGCATGCTGG GACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTT CATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGACATT GATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACTTTGAGTTGAAAGTAAACAC AAGCTGGCTGCTTCCCTGTGGCAACTGTGGCT

refseq_PTPRO.F2 (forward primer)
refseq_PTPRO.R2 (reverse primer)
Single exon skipping

Frame 0

K*KNGRGKRQSILPSKLDSYLYERTYFKGNIKS LWCSYLPIFELGDASPAY**KKKEYT**IKFFLK LCLCSEPAPPKSLFAVNKTQTSVTLLWVEEGVA DFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISS LLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEM NPNVVVISVLAILSTLLIGLLLVTLIILRKKHL QMARECGAGTFVNFASLERDGKLPYNWRRSIFA FLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTN PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIG LDIPHFAADLPLNRCKNRYTNILPYDFSRVRLV SMNEEEGADYINANYIPGYNSPQEYIATQGPLPE TRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDH YWPFTEEPIAYGDITVEMISEEEQDDWACRHFR INYADEMQDVMHFNYTAWPDHGVPTANAAESILQ FVHMVRQQATKSKGPMIIHCSAGVGRTGTFIAL DRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTE EQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS *FRIRSREDMMCAHPPLLPDCFSGP*WSFF*TE ALLCNMWPRR*FISQKHREDLALKSLQCPFGLF HFGTFNNGPNSTEHQEGQDALQRAGSTALPKSLV GPLLVGLSFLFLSVCFSVQ*FLCVCDSYQKVEL FSAYTVHQPHNPGRNRHC*HQIIPHY*KEAWPH MKKWSFYFKEIEPALSVLQHYRIWIGEVGQGREG FYPQINCVIFYYSSYNSASK*SRKKIVLTVLVL DGFLPY*QLVFLPWPFWTNVTVQVLSQETTSGS EECQVGLFELCCCLSNRGA*TLHSLFC*PAYM*E LFL*ELYRL*KRTFFPPKSWEFMKLWQ*TAACW DNYLTTFFCNIVKCLYGF*QRFLFVLLFFWLSV SF*RV*LVTFYSLDFV*LQYMIVYCDMNAVKMTL MAL*SLLLCVTS**IRGDDMDIQQKTL*VESKH KLAASLWQLW

Frame 1

SKKMEGGKGKVFCLPS*IAIFMKGHISKAI*SL YGALTYLYLNWGMLHLLISERRKNTLSKLNFF* NFVFAQNQLHPNHSSQ*TKPRLQ*LCCGWKRE*L ISLKFSVNKLAPVRKPNFRNQLLFLPMS*PSPA FFLPLPTIVVSPALAMTAPVSLRS*PSQQWLQR *IPMW**SPCWPSLAHF*LDCCLLPSLFLGKSIC RWLGSVELVHLSILHP*RGMESFHTTGVGVYLL S*PCYPHVFGLIIFWHFILILGVKMV*RRGN*Q TRFNWMTLMPILRIWPKTLTINFLFSLRS*N*LD WISHTLLQIFH*IDVKTVTQTSYHMTSAV*D*S P*MKRKVQTTSMPTIFLDTTHPRSILPPRGHCL KPEMTSGRWSCNKSLRLLSCSLSVMRKGG*NVTI TGHSRKNL*PMETSLWR*FQRKSRTTGPVDTSG STMLTRCRM*CILTTLHGLIMVCPQQMLQKVSC SLYTWSDSKLPRAKVP*SFTAVLAWDGQEHSLPW TGSCSTFGIMSLLTS*GWCQK*GHTGCLWYRQR SSTFLSISVCN*CG*RRSSSSASVMSYTRMLAS PSSESGAERT*CAPILPCFQIVLVGPDGHFSKQR PCFVICGQGDNLSHRSTGKT*P*RAYSVLLDSF TSGHLIMDQIQQNTRKVKTLSKGQEVQHFRRV* LALCWLG*VFYF*VFVFQCNNFCVCVILIRKLNC FLPTPFISPITQEGTGIVSIRLYLIIKRRHGHT *RNGHSTSKKLSQHYLYSNITGSGLGRLVREER GSTHRSTV*SFTIQAIIQLQSRVEKKLS*LF*FL MVFFLINSWCFFLGPFGLMLLSKFFLKKPHLVQ KSVKLDSLNSVAV*AIVVPRLCIPCSVDLHTCE SYFFKNYIGCENALSFPQRAGNL*SYGNELQHAG TII*LLFFVILSNVSMDSDRDFFLFCYSFGCQF HFNECN**HFILWILYNYST*LCIVT*MLSK*H *WHCEACYFVSLPDK*EVMTWIYNRKHFELKVNT SWLLPCGNCG

Frame 2

VKKWKGEKAKYSAFQVR*LSL*KDIFQRQYKVF MVLLPTYI*IGGCFTCLLVKEERIHLVN*IFFK TLSLLRTSSTQITLRSEQNPDFSDFAVGGRGSS *FL*SFLSTSWLQSENQTSGTSCCFFPCRDHLQP SSCHCLQL*CHQL*P*QPQCPYVHSRLNNGYRD ESQCGSDLRAGHP*HTFNWTVACYPHYS*EKAS ADG*GVWSWYICQFCILREGWKASIQLA*EYICF LNPATLMSLD*LSFGILY*SLE*KWFKEEETDK PGSTG*L*CLY*GYGQRL*L*IFSSV*GVEIDW TGYPTLCCRSSTESM*KPLHKHPTI*LQPCEISL HE*RGRCRLHQCQLYSWIQLTPGVYCHPGATA* NQK*LLEDGPATKVSDYCHAHSV**EKEGEM*P LLAIHGRTYSLWRHHCGDDFRGRAGRLGL*TLPD QLC*RDAGCDAF*LHCMA*SWCAHSKCCRKYPA VCTHGPTASYQEQRSHDHSLQCWRGTDRNIHCP GQALAAHSGS*VC*HLRAGVRNEVIPDVYGTDRG AVHFYPSVCATDVDEEEAAVLHQ*CHIREC*QV LVQNPEQRGHDVRPSSLASRLF*WALMVIFLNR GPAL*YVAKEIIYLTEAPGRLSLKEPTVSFWTLS LRDI**WTKFNRTPGRSRRSPKGRKYSTSEEFS WPFAGWAEFFIFKCLFFSAIIFVCV*FLSES*I VFCLHRSSAP*PRKEQALLASDYTSLLKGGMATH EEMVILLQRN*ASTICTPTLPDLDWGGWSGKRG VLPTDQLCNLLLFKL*FSFKVE*KKNCLNCSSS *WFSSLLTVGVSSLALLD*CYCPSSFSRNHIWFR RVSSWTL*TLLLSEQSWCLDFAFLVLLTCIHVR AISLRTI*AVKTHFLSPKELGIYEVMAMNCSML GQLFDYFFL*YCQMSLWILTEISFCFVILLVVSF ILTSVTSNILFFGFCIITVHDCVL*HECCQNDI DGIVKPVTLCHFLINKR**HGYTTENTLS*K*T QAGCFPVATVA

Sequence NM_030667

GGGCGCAGAGGAGGAAAGGGAGCAGGCGCAGGGGGACTGGAAAGGCAGCATGCGCTCGCCAGGAGCAACCTCGGCGCCCAGGGTCTGAGGCTGCAGCCCC AGTTCGCCATTGTGAGCCGCCGCCGGGGGAGTCCGCTAGCGCAGCCGTGCCCCCGAGTCCCCGTCCGCGCAGCGATGGGGCACCTGCCCACGGGGATACA CGGCGCCCGCCGCCTCCTGCCTCTGCTCTGGCTCTTTGTGCTGTTCAAGAATGCTACAGCTTTCCATGTAACTGTCCAAGATGATAATAACATCGTTGTC TCATTAGAAGCTTCAGACGTCATCAGTCCAGCATCTGTGTATGTTGTGAAGATAACTGGTGAATCCAAAAATTATTTCTTCGAATTTGAGGAATTCAACA GCACTTTGCCTCCTCCTGTTATTTTCAAGGCCAGTTATCATGGCCTTTATTATATAATCACTCTGGTAGTGGTAAATGGAAATGTGGTGACCAAGCCATC CAGATCAATCACTGTGTTAACAAAACCTCTACCTGTAACCAGTGTTTCCATATATGACTATAAACCTTCTCCTGAAACAGGAGTCCTGTTTGAAATACAT TATCCAGAAAAATATAACGTTTTCACAAGAGTGAACATTAGCTACTGGGAAGGTAAAGACTTCCGGACAATGCTATATAAAGATTTCTTTAAGGGAAAAA CAGTATTTAATCACTGGCTGCCAGGAATGTGTTATAGTAATATCACCTTTCAGCTGGTATCTGAGGCAACTTTTAATAAAAGTACCCTTGTTGAGTACAG TGGTGTCAGTCACGAACCCAAACAGCACAGAACTGCCCCTTATCCACCTCAAAATATTTCCGTTCGTATCGTAAACTTGAACAAAAACAACTGGGAAGAA CAGAGTGGCAATTTCCCAGAAGAATCCTTCATGAGATCACAAGATACAATAGGAAAAGAAAAACTCTTCCATTTTACAGAAGAAACCCCTGAAATTCCCT CGGGCAACATTTCTTCCGGTTGGCCTGATTTTAATAGCAGTGACTATGAAACTACGTCTCAGCCATATTGGTGGGACAGTGCATCTGCAGCTCCTGAAAG TGAAGATGAATTTGTCAGCGTACTTCCCATGGAATACGAAAATAACAGTACACTCAGTGAGACAGAGAAGTCAACATCAGGCTCTTTCTCCTTTTTCCCT GTGCAAATGATATTGACCTGGTTACCACCCAAACCACCCACTGCTTTTGATGGGTTCCATATCCATATTGAACGAGAAGAGAACTTTACTGAATATTTGA TGGTGGATGAAGAAGCACATGAATTTGTTGCAGAACTGAAGGAACCTGGGAAATATAAGTTATCTGTGACAACCTTTAGTTCCTCAGGATCTTGTGAAAC TCGAAAAAGTCAGTCAGCAAAATCACTCAGCTTTTATATCAGTCCTTCAGGAGAGTGGATTGAAGAACTGACCGAGAAGCCGCAGCACGTGAGTGTCCAC GTTTTAAGCTCAACCACTGCCTTGATGTCCTGGACATCTTCCCAAGAGAACTACAACAGCACCATTGTGTCTGTGGTGTCGCTGACCTGCCAGAAACAAA AGGAGAGCCAGAGGCTTGAAAAGCAGTACTGCACTCAGGTGAACTCAAGCAAACCTATTATTGAAAATCTGGTTCCTGGTGCCCAGTACCAGGTTGTAAT ATACCTAAGGAAAGGCCCTTTGATTGGACCACCTTCAGATCCTGTGACATTTGCTATTGTTCCCACAGGAATAAAGGATTTAATGCTCTATCCTTTGGGT CCTACGGCCGTGGTTCTGAGCTGGACCAGACCTTATTTAGGCGTGTTCAGAAAATACGTGGTTGAAATGTTTTATTTCAACCCTGCTACAATGACATCAG AGTGGACCACCTACTATGAAATAGCAGCAACTGTTTCCTTAACTGCATCCGTGAGAATAGCTAATCTGCTGCCAGCATGGTACTACAACTTCCGGGTTAC CATGGTGACGTGGGGAGATCCAGAATTGAGCTGCTGTGACAGCTCTACCATCAGCTTCATAACAGCCCCAGTGGCTCCGGAAATCACTTCTGTGGAATAT TTCAACAGTCTGTTATATATCAGTTGGACATATGGGGATGATACAACGGACTTGTCCCATTCTAGAATGCTTCACTGGATGGTGGTTGCAGAAGGAAAAA AGAAAATTAAAAAGAGTGTAACACGCAATGTCATGACTGCAATTCTCAGCTTGCCTCCAGGCGACATCTATAACCTCTCAGTAACTGCTTGTACTGAAAG AGGAAGTAATACCTCCATGCTCCGCCTTGTCAAGCTAGAACCAGCTCCACCCAAATCACTCTTCGCAGTGAACAAAACCCAGACTTCAGTGACTTTGCTG TGGGTGGAAGAGGGAGTAGCTGATTTCTTTGAAGTTTTCTGTCAACAAGTTGGCTCCAGTCAGAAAACCAAACTTCAGGAACCAGTTGCTGTTTCTTCCC ATGTCGTGACCATCTCCAGCCTTCTTCCTGCCACTGCCTACAATTGTAGTGTCACCAGCTTTAGCCATGACAGCCCCAGTGTCCCTACGTTCATAGCCGT CTCAACAATGGTTACAGAGATGAATCCCAATGTGGTAGTGATCTCCGTGCTGGCCATCCTTAGCACACTTTTAATTGGACTGTTGCTTGTTACCCTCATT ATTCTTAGGAAAAAGCATCTGCAGATGGCTAGGGAGTGTGGAGCTGGTACATTTGTCAATTTTGCATCCTTAGAGAGGGATGGAAAGCTTCCATACAACT GGCGTAGGAGTATATTTGCTTTCTTAACCCTGCTACCCTCATGTCTTTGGACTGATTATCTTTTGGCATTTTATATTAATCCTTGGAGTAAAAATGGTTT AAAGAAGAGGAAACTGACAAACCCGGTTCAACTGGATGACTTTGATGCCTATATTAAGGATATGGCCAAAGACTCTGACTATAAATTTTCTCTTCAGTTT GAGGAGTTGAAATTGATTGGACTGGATATCCCACACTTTGCTGCAGATCTTCCACTGAATCGATGTAAAAACCGTTACACAAACATCCTACCATATGACT TCAGCCGTGTGAGATTAGTCTCCATGAATGAAGAGGAAGGTGCAGACTACATCAATGCCAACTATATTCCTGGATACAACTCACCCCAGGAGTATATTGC CACCCAGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAA AGGAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACT GGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAA TGCTGCAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGG ACAGGAACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGA TGTCTATGGTACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCAT ATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAGTGGGCCCTGA TGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTAGCCTTAAAGAGCCTAC AGTGTCCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCCAAAGGGCAGGAAGTAC AGCACTTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGAT TCTTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATTATT AAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGATCTGGATTGGGGA GGTTGGTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTAGAGTAGAAAAAAAATT GTCTTAACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTC AAGAAACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTG TTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTATGAAGTTATGG CAATGAACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGATTTCTTTTTGTTTTGT TATTCTTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGATTGTGTATTGTGACAT GAATGCTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGATATACAACAGAAAACA CTTTGAGTTGAAAGTAAACACAAGCTGGCTGCTTCCCTGTGGCAACTGTGGCT

refseq_PTPRO.F2 (forward primer)
refseq_PTPRO.R2 (reverse primer)
Single exon skipping

Frame 0

GRRGGKGAGAGGLERQHALARSNLGAQGLRLQP QFAIVSRRRGSPLAQPCPRVPVRAAMGHLPTGIH GARRLLPLLWLFVLFKNATAFHVTVQDDNNIVV SLEASDVISPASVYVVKITGESKNYFFEFEEFN STLPPPVIFKASYHGLYYIITLVVVNGNVVTKPS RSITVLTKPLPVTSVSIYDYKPSPETGVLFEIH YPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGK TVFNHWLPGMCYSNITFQLVSEATFNKSTLVEYS GVSHEPKQHRTAPYPPQNISVRIVNLNKNNWEE QSGNFPEESFMRSQDTIGKEKLFHFTEETPEIP SGNISSGWPDFNSSDYETTSQPYWWDSASAAPES EDEFVSVLPMEYENNSTLSETEKSTSGSFSFFP VQMILTWLPPKPPTAFDGFHIHIEREENFTEYL MVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCET RKSQSAKSLSFYISPSGEWIEELTEKPQHVSVH VLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQ KESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVI YLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLG PTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTS EWTTYYEIAATVSLTASVRIANLLPAWYYNFRVT MVTWGDPELSCCDSSTISFITAPVAPEITSVEY FNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGK KKIKKSVTRNVMTAILSLPPGDIYNLSVTACTER GSNTSMLRLVKLEPAPPKSLFAVNKTQTSVTLL WVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSS HVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAV STMVTEMNPNVVVISVLAILSTLLIGLLLVTLI ILRKKHLQMARECGAGTFVNFASLERDGKLPYN WRRSIFAFLTLLPSCLWTDYLLAFYINPWSKNGL KKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQF EELKLIGLDIPHFAADLPLNRCKNRYTNILPYD FSRVRLVSMNEEEGADYINANYIPGYNSPQEYIA TQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEK RRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD WACRHFRINYADEMQDVMHFNYTAWPDHGVPTAN AAESILQFVHMVRQQATKSKGPMIIHCSAGVGR TGTFIALDRLLQHIRDHEFVDILGLVSEMRSYR MSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVI YENVSKS*FRIRSREDMMCAHPPLLPDCFSGP* WSFF*TEALLCNMWPRR*FISQKHREDLALKSL QCPFGLFHFGTFNNGPNSTEHQEGQDALQRAGST ALPKSLVGPLLVGLSFLFLSVCFSVQ*FLCVCD SYQKVELFSAYTVHQPHNPGRNRHC*HQIIPHY *KEAWPHMKKWSFYFKEIEPALSVLQHYRIWIGE VGQGREGFYPQINCVIFYYSSYNSASK*SRKKI VLTVLVLDGFLPY*QLVFLPWPFWTNVTVQVLS QETTSGSEECQVGLFELCCCLSNRGA*TLHSLFC *PAYM*ELFL*ELYRL*KRTFFPPKSWEFMKLW Q*TAACWDNYLTTFFCNIVKCLYGF*QRFLFVL LFFWLSVSF*RV*LVTFYSLDFV*LQYMIVYCDM NAVKMTLMAL*SLLLCVTS**IRGDDMDIQQKT L*VESKHKLAASLWQLW

Frame 1

GAEEEREQAQGDWKGSMRSPGATSAPRV*GCSP SSPL*AAAGGVR*RSRAPESPSAQRWGTCPRGY TAPAASCLCSGSLCCSRMLQLSM*LSKMIITSLS H*KLQTSSVQHLCML*R*LVNPKIISSNLRNST ALCLLLLFSRPVIMAFII*SLW*W*MEMW*PSH PDQSLC*QNLYL*PVFPYMTINLLLKQESCLKYI IQKNITFSQE*TLATGKVKTSGQCYIKISLREK QYLITGCQECVIVISPFSWYLRQLLIKVPLLST VVSVTNPNSTELPLIHLKIFPFVS*T*TKTTGKN RVAISQKNPS*DHKIQ*EKKNSSILQKKPLKFP RATFLPVGLILIAVTMKLRLSHIGGTVHLQLLK VKMNLSAYFPWNTKITVHSVRQRSQHQALSPFSL CK*Y*PGYHPNHPLLLMGSISILNEKRTLLNI* WWMKKHMNLLQN*RNLGNISYL*QPLVPQDLVK LEKVSQQNHSAFISVLQESGLKN*PRSRST*VST F*AQPLP*CPGHLPKRTTTAPLCLWCR*PARNK RRARGLKSSTALR*TQANLLLKIWFLVPSTRL* YT*GKAL*LDHLQIL*HLLLFPQE*RI*CSILWV LRPWF*AGPDLI*ACSENTWLKCFISTLLQ*HQ SGPPTMK*QQLFP*LHP*E*LICCQHGTTTSGL PW*RGEIQN*AAVTALPSAS*QPQWLRKSLLWNI STVCYISVGHMGMIQRTCPILECFTGWWLQKEK RKLKRV*HAMS*LQFSACLQATSITSQ*LLVLK EEVIPPCSALSS*NQLHPNHSSQ*TKPRLQ*LCC GWKRE*LISLKFSVNKLAPVRKPNFRNQLLFLP MS*PSPAFFLPLPTIVVSPALAMTAPVSLRS*P SQQWLQR*IPMW**SPCWPSLAHF*LDCCLLPSL FLGKSICRWLGSVELVHLSILHP*RGMESFHTT GVGVYLLS*PCYPHVFGLIIFWHFILILGVKMV *RRGN*QTRFNWMTLMPILRIWPKTLTINFLFSL RS*N*LDWISHTLLQIFH*IDVKTVTQTSYHMT SAV*D*SP*MKRKVQTTSMPTIFLDTTHPRSIL PPRGHCLKPEMTSGRWSCNKSLRLLSCSLSVMRK GG*NVTITGHSRKNL*PMETSLWR*FQRKSRTT GPVDTSGSTMLTRCRM*CILTTLHGLIMVCPQQ MLQKVSCSLYTWSDSKLPRAKVP*SFTAVLAWDG QEHSLPWTGSCSTFGIMSLLTS*GWCQK*GHTG CLWYRQRSSTFLSISVCN*CG*RRSSSSASVMS YTRMLASPSSESGAERT*CAPILPCFQIVLVGPD GHFSKQRPCFVICGQGDNLSHRSTGKT*P*RAY SVLLDSFTSGHLIMDQIQQNTRKVKTLSKGQEV QHFRRV*LALCWLG*VFYF*VFVFQCNNFCVCVI LIRKLNCFLPTPFISPITQEGTGIVSIRLYLII KRRHGHT*RNGHSTSKKLSQHYLYSNITGSGLG RLVREERGSTHRSTV*SFTIQAIIQLQSRVEKKL S*LF*FLMVFFLINSWCFFLGPFGLMLLSKFFL KKPHLVQKSVKLDSLNSVAV*AIVVPRLCIPCS VDLHTCESYFFKNYIGCENALSFPQRAGNL*SYG NELQHAGTII*LLFFVILSNVSMDSDRDFFLFC YSFGCQFHFNECN**HFILWILYNYST*LCIVT *MLSK*H*WHCEACYFVSLPDK*EVMTWIYNRKH FELKVNTSWLLPCGNCG

Frame 2

AQRRKGSRRRGTGKAACARQEQPRRPGSEAAAP VRHCEPPPGESASAAVPPSPRPRSDGAPAHGDT RRPPPPASALALCAVQECYSFPCNCPR***HRC LIRSFRRHQSSICVCCEDNW*IQKLFLRI*GIQQ HFASSCYFQGQLSWPLLYNHSGSGKWKCGDQAI QINHCVNKTSTCNQCFHI*L*TFS*NRSPV*NT LSRKI*RFHKSEH*LLGR*RLPDNAI*RFL*GKN SI*SLAARNVL**YHLSAGI*GNF**KYPC*VQ WCQSRTQTAQNCPLSTSKYFRSYRKLEQKQLGR TEWQFPRRILHEITRYNRKRKTLPFYRRNP*NSL GQHFFRLA*F**Q*L*NYVSAILVGQCICSS*K *R*ICQRTSHGIRK*QYTQ*DREVNIRLFLLFP CANDIDLVTTQTTHCF*WVPYPY*TRRELY*IFD GG*RST*ICCRTEGTWEI*VICDNL*FLRIL*N SKKSVSKITQLLYQSFRRVD*RTDREAAARECP RFKLNHCLDVLDIFPRELQQHHCVCGVADLPETK GEPEA*KAVLHSGELKQTYY*KSGSWCPVPGCN IPKERPFDWTTFRSCDICYCSHRNKGFNALSFG SYGRGSELDQTLFRRVQKIRG*NVLFQPCYNDIR VDHLL*NSSNCFLNCIRENS*SAASMVLQLPGY HGDVGRSRIELL*QLYHQLHNSPSGSGNHFCGI FQQSVIYQLDIWG*YNGLVPF*NASLDGGCRRKK EN*KECNTQCHDCNSQLASRRHL*PLSNCLY*K RK*YLHAPPCQARTSSTQITLRSEQNPDFSDFA VGGRGSS*FL*SFLSTSWLQSENQTSGTSCCFFP CRDHLQPSSCHCLQL*CHQL*P*QPQCPYVHSR LNNGYRDESQCGSDLRAGHP*HTFNWTVACYPH YS*EKASADG*GVWSWYICQFCILREGWKASIQL A*EYICFLNPATLMSLD*LSFGILY*SLE*KWF KEEETDKPGSTG*L*CLY*GYGQRL*L*IFSSV *GVEIDWTGYPTLCCRSSTESM*KPLHKHPTI*L QPCEISLHE*RGRCRLHQCQLYSWIQLTPGVYC HPGATA*NQK*LLEDGPATKVSDYCHAHSV**E KEGEM*PLLAIHGRTYSLWRHHCGDDFRGRAGRL GL*TLPDQLC*RDAGCDAF*LHCMA*SWCAHSK CCRKYPAVCTHGPTASYQEQRSHDHSLQCWRGT DRNIHCPGQALAAHSGS*VC*HLRAGVRNEVIPD VYGTDRGAVHFYPSVCATDVDEEEAAVLHQ*CH IREC*QVLVQNPEQRGHDVRPSSLASRLF*WAL MVIFLNRGPAL*YVAKEIIYLTEAPGRLSLKEPT VSFWTLSLRDI**WTKFNRTPGRSRRSPKGRKY STSEEFSWPFAGWAEFFIFKCLFFSAIIFVCV* FLSES*IVFCLHRSSAP*PRKEQALLASDYTSLL KGGMATHEEMVILLQRN*ASTICTPTLPDLDWG GWSGKRGVLPTDQLCNLLLFKL*FSFKVE*KKN CLNCSSS*WFSSLLTVGVSSLALLD*CYCPSSFS RNHIWFRRVSSWTL*TLLLSEQSWCLDFAFLVL LTCIHVRAISLRTI*AVKTHFLSPKELGIYEVM AMNCSMLGQLFDYFFL*YCQMSLWILTEISFCFV ILLVVSFILTSVTSNILFFGFCIITVHDCVL*H ECCQNDIDGIVKPVTLCHFLINKR**HGYTTEN TLS*K*TQAGCFPVATVA

Sequence NM_030671

AAGTAAAAAAATGGAAGGGGGAAAAGGCAAAGTATTCTGCCTTCCAAGTTAGATAGCTATCTTTATGAAAGGACATATTTCAAAGGCAATATAAAGTCTT TATGGTGCTCTTACCTACCTATATTTGAATTGGGGGATGCTTCACCTGCTTATTAGTGAAAGAAGAAAGAATACACTTAGTAAATTAAATTTTTTTTAAA ACTTTGTCTTTGCTCAGAACCAGCTCCACCCAAATCACTCTTCGCAGTGAACAAAACCCAGACTTCAGTGACTTTGCTGTGGGTGGAAGAGGGAGTAGCT GATTTCTTTGAAGTTTTCTGTCAACAAGTTGGCTCCAGTCAGAAAACCAAACTTCAGGAACCAGTTGCTGTTTCTTCCCATGTCGTGACCATCTCCAGCC TTCTTCCTGCCACTGCCTACAATTGTAGTGTCACCAGCTTTAGCCATGACAGCCCCAGTGTCCCTACGTTCATAGCCGTCTCAACAATGGTTACAGAGAT GAATCCCAATGTGGTAGTGATCTCCGTGCTGGCCATCCTTAGCACACTTTTAATTGGACTGTTGCTTGTTACCCTCATTATTCTTAGGAAAAAGCATCTG CAGATGGCTAGGGAGTGTGGAGCTGGTACATTTGTCAATTTTGCATCCTTAGAGAGGGATGGAAAGCTTCCATACAACTGGCGTAGGAGTATATTTGCTT TCTTAACCCTGCTACCCTCATGTCTTTGGACTGATTATCTTTTGGCATTTTATATTAATCCTTGGAGTAAAAATGGTTTAAAGAAGAGGAAACTGACAAA CCCGGTTCAACTGGATGACTTTGATGCCTATATTAAGGATATGGCCAAAGACTCTGACTATAAATTTTCTCTTCAGTTTGAGGAGTTGAAATTGATTGGA CTGGATATCCCACACTTTGCTGCAGATCTTCCACTGAATCGATGTAAAAACCGTTACACAAACATCCTACCATATGACTTCAGCCGTGTGAGATTAGTCT CCATGAATGAAGAGGAAGGTGCAGACTACATCAATGCCAACTATATTCCTGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGA AACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAGGGTGAAATGTGACCAT TACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGA TCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCA GTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCCTG GACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGGTACAGACAGAGG AGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTC CTAGTTCAGAATCCGGAGCAGTAAGTGGAGAAGAGCTCTCCACGAGTGCTCAGTCTTAGAACTATTAGAGGGGGATGTGATGGATGGGACAAAAGACAGC AGTAGCCATTTGTATTGACTCTGACTTCACATGAGTATTTCTTCCCAGCTCCTGGCCTCACATGGGTGGTCACAGGGAGAAACAAGTACTGTAGCAGATC TTTGAGTTTCAATGCACCTTGGTTGGTGTTGGCAACAAACAGGAGCTTCTGCACATCATGATGACTTTACCTCCATTCCCTCTACCCAGAACCCTAAATT ATTCTGTTATTGGATCTGTGCCTGTAATATCAGGATACTACCATCCAAATCTATCTAGATATCTTGTGCAAATATTTTATTGATTACAAGGGCTGTATAC GGGGTTACAAAAAGACATGAGCTGGATTGGACACTCCTAAAACCAAAAACAACAGTGACAATAGAGTCTCAGGATAGCAGAGTCTGAAAATACCTTGGTC TCCCCCATTATGTGAGCCCTTACTTGAGAGCTTCATGAAGACACTTGTAACATATTCAACGTCCTGTACTCCAGTTTTGACTACGAGATCAGATTTTGGA GGTGTAAGTAAACTTGGCTGAGGTAACAGTAATCTGCCCATTTAGTTCAGTAAACAGACTGTAGAGTGTCTGACTATACTGGGGGAAGAGGAGCCAATGA CAGGGTAGGGAGATGACAGTGGTGCATGATGGGAGAATCATGAAAGTCTGGGAAGCATATGGACCAGTGGGAAGGATAGGATTAGCACTGCACCTCTACA TCCATCAAGAGAGACAGAGCGCACAATGGAGCAGGAAGGATAAAAAATAAAGAAAGACAGAGAGAAACAAATTTGCTGGGAGAGGGAAAGACATTCAGAC CCACAGAAAGGAGGCAGCACACAGAGAAAGATGCACAGATCAACCCACATCTGCATGGGTTGTGAGACTGAGCATAGTGAGAGCAGTGGTGGAGCAATAG AAGATTGCTGTGACACCAGGCTGCTTACTGTCTTTCTTTGTCTCATTCACAGGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTA GTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTAGCCTT AAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCCAAAGG GCAGGAAGTACAGCACTTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATTTTTGT GTGTGTGTGATTCTTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTAT ACCTCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGATC TGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTAGAGTA GAAAAAAAATTGTCTTAACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACTGTCCA AGTTCTTTCTCAAGAAACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCAT TCCTTGTTCTGTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTA TGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGATTTCT TTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGATTGTG TATTGTGACATGAATGCTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGATATAC AACAGAAAACACTTTGAGTTGAAAGTAAACACAAGCTGGCTGCTTCCCTGTGGCAACTGTGGCT

refseq_PTPRO.F2 (forward primer)
refseq_PTPRO.R2 (reverse primer)
Single exon skipping

Frame 0

K*KNGRGKRQSILPSKLDSYLYERTYFKGNIKS LWCSYLPIFELGDASPAY**KKKEYT**IKFFLK LCLCSEPAPPKSLFAVNKTQTSVTLLWVEEGVA DFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISS LLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEM NPNVVVISVLAILSTLLIGLLLVTLIILRKKHL QMARECGAGTFVNFASLERDGKLPYNWRRSIFA FLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTN PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIG LDIPHFAADLPLNRCKNRYTNILPYDFSRVRLV SMNEEEGADYINANYIPGYNSPQEYIATQGPLPE TRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDH YWPFTEEPIAYGDITVEMISEEEQDDWACRHFR INYADEMQDVMHFNYTAWPDHGVPTANAAESILQ FVHMVRQQATKSKGPMIIHCSAGVGRTGTFIAL DRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTE EQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS *FRIRSSKWRRALHECSVLELLEGDVMDGTKDS SSHLY*L*LHMSISSQLLASHGWSQGETSTVAD L*VSMHLGWCWQQTGASAHHDDFTSIPSTQNPKL FCYWICACNIRILPSKSI*ISCANILLITRAVY GVTKRHELDWTLLKPKTTVTIESQDSRV*KYLG LPHYVSPYLRAS*RHL*HIQRPVLQF*LRDQILE V*VNLAEVTVICPFSSVNRL*SV*LYWGKRSQ* QGREMTVVHDGRIMKVWEAYGPVGRIGLALHLY IHQERQSAQWSRKDKK*RKTERNKFAGRGKDIQT HRKEAAHRERCTDQPTSAWVVRLSIVRAVVEQ* KIAVTPGCLLSFFVSFTGEDMMCAHPPLLPDCF SGP*WSFF*TEALLCNMWPRR*FISQKHREDLAL KSLQCPFGLFHFGTFNNGPNSTEHQEGQDALQR AGSTALPKSLVGPLLVGLSFLFLSVCFSVQ*FL CVCDSYQKVELFSAYTVHQPHNPGRNRHC*HQII PHY*KEAWPHMKKWSFYFKEIEPALSVLQHYRI WIGEVGQGREGFYPQINCVIFYYSSYNSASK*S RKKIVLTVLVLDGFLPY*QLVFLPWPFWTNVTVQ VLSQETTSGSEECQVGLFELCCCLSNRGA*TLH SLFC*PAYM*ELFL*ELYRL*KRTFFPPKSWEF MKLWQ*TAACWDNYLTTFFCNIVKCLYGF*QRFL FVLLFFWLSVSF*RV*LVTFYSLDFV*LQYMIV YCDMNAVKMTLMAL*SLLLCVTS**IRGDDMDI QQKTL*VESKHKLAASLWQLW

Frame 1

SKKMEGGKGKVFCLPS*IAIFMKGHISKAI*SL YGALTYLYLNWGMLHLLISERRKNTLSKLNFF* NFVFAQNQLHPNHSSQ*TKPRLQ*LCCGWKRE*L ISLKFSVNKLAPVRKPNFRNQLLFLPMS*PSPA FFLPLPTIVVSPALAMTAPVSLRS*PSQQWLQR *IPMW**SPCWPSLAHF*LDCCLLPSLFLGKSIC RWLGSVELVHLSILHP*RGMESFHTTGVGVYLL S*PCYPHVFGLIIFWHFILILGVKMV*RRGN*Q TRFNWMTLMPILRIWPKTLTINFLFSLRS*N*LD WISHTLLQIFH*IDVKTVTQTSYHMTSAV*D*S P*MKRKVQTTSMPTIFLDTTHPRSILPPRGHCL KPEMTSGRWSCNKSLRLLSCSLSVMRKGG*NVTI TGHSRKNL*PMETSLWR*FQRKSRTTGPVDTSG STMLTRCRM*CILTTLHGLIMVCPQQMLQKVSC SLYTWSDSKLPRAKVP*SFTAVLAWDGQEHSLPW TGSCSTFGIMSLLTS*GWCQK*GHTGCLWYRQR SSTFLSISVCN*CG*RRSSSSASVMSYTRMLAS PSSESGAVSGEELSTSAQS*NY*RGM*WMGQKTA VAICIDSDFT*VFLPSSWPHMGGHREKQVL*QI FEFQCTLVGVGNKQELLHIMMTLPPFPLPRTLN YSVIGSVPVISGYYHPNLSRYLVQIFY*LQGLYT GLQKDMSWIGHS*NQKQQ*Q*SLRIAESENTLV SPIM*ALT*ELHEDTCNIFNVLYSSFDYEIRFW RCK*TWLR*Q*SAHLVQ*TDCRVSDYTGGRGAND RVGR*QWCMMGES*KSGKHMDQWEG*D*HCTST SIKRDRAHNGAGRIKNKERQRETNLLGEGKTFR PTERRQHTEKDAQINPHLHGL*D*A**EQWWSNR RLL*HQAAYCLSLSHSQERT*CAPILPCFQIVL VGPDGHFSKQRPCFVICGQGDNLSHRSTGKT*P *RAYSVLLDSFTSGHLIMDQIQQNTRKVKTLSKG QEVQHFRRV*LALCWLG*VFYF*VFVFQCNNFC VCVILIRKLNCFLPTPFISPITQEGTGIVSIRL YLIIKRRHGHT*RNGHSTSKKLSQHYLYSNITGS GLGRLVREERGSTHRSTV*SFTIQAIIQLQSRV EKKLS*LF*FLMVFFLINSWCFFLGPFGLMLLS KFFLKKPHLVQKSVKLDSLNSVAV*AIVVPRLCI PCSVDLHTCESYFFKNYIGCENALSFPQRAGNL *SYGNELQHAGTII*LLFFVILSNVSMDSDRDF FLFCYSFGCQFHFNECN**HFILWILYNYST*LC IVT*MLSK*H*WHCEACYFVSLPDK*EVMTWIY NRKHFELKVNTSWLLPCGNCG

Frame 2

VKKWKGEKAKYSAFQVR*LSL*KDIFQRQYKVF MVLLPTYI*IGGCFTCLLVKEERIHLVN*IFFK TLSLLRTSSTQITLRSEQNPDFSDFAVGGRGSS *FL*SFLSTSWLQSENQTSGTSCCFFPCRDHLQP SSCHCLQL*CHQL*P*QPQCPYVHSRLNNGYRD ESQCGSDLRAGHP*HTFNWTVACYPHYS*EKAS ADG*GVWSWYICQFCILREGWKASIQLA*EYICF LNPATLMSLD*LSFGILY*SLE*KWFKEEETDK PGSTG*L*CLY*GYGQRL*L*IFSSV*GVEIDW TGYPTLCCRSSTESM*KPLHKHPTI*LQPCEISL HE*RGRCRLHQCQLYSWIQLTPGVYCHPGATA* NQK*LLEDGPATKVSDYCHAHSV**EKEGEM*P LLAIHGRTYSLWRHHCGDDFRGRAGRLGL*TLPD QLC*RDAGCDAF*LHCMA*SWCAHSKCCRKYPA VCTHGPTASYQEQRSHDHSLQCWRGTDRNIHCP GQALAAHSGS*VC*HLRAGVRNEVIPDVYGTDRG AVHFYPSVCATDVDEEEAAVLHQ*CHIREC*QV LVQNPEQ*VEKSSPRVLSLRTIRGGCDGWDKRQ Q*PFVLTLTSHEYFFPAPGLTWVVTGRNKYCSRS LSFNAPWLVLATNRSFCTS**LYLHSLYPEP*I ILLLDLCL*YQDTTIQIYLDILCKYFIDYKGCI RGYKKT*AGLDTPKTKNNSDNRVSG*QSLKIPWS PPLCEPLLESFMKTLVTYSTSCTPVLTTRSDFG GVSKLG*GNSNLPI*FSKQTVECLTILGEEEPM TG*GDDSGA*WENHESLGSIWTSGKDRISTAPLH PSRETERTMEQEG*KIKKDREKQICWERERHSD PQKGGSTQRKMHRSTHICMGCETEHSESSGGAI EDCCDTRLLTVFLCLIHRRGHDVRPSSLASRLF* WALMVIFLNRGPAL*YVAKEIIYLTEAPGRLSL KEPTVSFWTLSLRDI**WTKFNRTPGRSRRSPK GRKYSTSEEFSWPFAGWAEFFIFKCLFFSAIIFV CV*FLSES*IVFCLHRSSAP*PRKEQALLASDY TSLLKGGMATHEEMVILLQRN*ASTICTPTLPD LDWGGWSGKRGVLPTDQLCNLLLFKL*FSFKVE* KKNCLNCSSS*WFSSLLTVGVSSLALLD*CYCP SSFSRNHIWFRRVSSWTL*TLLLSEQSWCLDFA FLVLLTCIHVRAISLRTI*AVKTHFLSPKELGIY EVMAMNCSMLGQLFDYFFL*YCQMSLWILTEIS FCFVILLVVSFILTSVTSNILFFGFCIITVHDC VL*HECCQNDIDGIVKPVTLCHFLINKR**HGYT TENTLS*K*TQAGCFPVATVA