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Sequences

Sequence NM_031268

GCCGGGGGCGGGGGGCGGCGGGCGACGGGGCGGGCGCAGGATGAGGGCGGCCATTGCTGGGGCTCCGCTTCGGGGAGGAGGACGCTGAGGAGGCGCCGAG CCGCGCAGCGCTGCGGGGGAGGCGCCCGCGCCGACGCGGGGCCCATGGCCAGGACCACCAGCCAGCTGTATGACGCCGTGCCCATCCAGTCCAGCGTGGT GTTATGTTCCTGCCCATCCCCATCAATGGTGAGGACCCAGACTGAGTCCAGCACGCCCCCTGGCATTCCTGGTGGCAGCAGGCAGGGCCCCGCCATGGAC GGCACTGCAGCCGAGCCTCGGCCCGGCGCCGGCTCCCTGCAGCATGCCCAGCCTCCGCCGCAGCCTCGGAAGAAGCGGCCTGAGGACTTCAAGTTTGGGA AAATCCTTGGGGAAGGCTCTTTTTCCACGGTTGTCCTGGCTCGAGAACTGGCAACCTCCAGAGAATATGCGACCAGGGCCAACTCATTCGTGGGAACAGC GCAGTACGTTTCTCCAGAGCTGCTCACGGAGAAGTCCGCCTGTAAGAGTTCAGACCTTTGGGCTCTTGGATGCATAATATACCAGCTTGTGGCAGGACTC CCACCATTCCGAGCTGGAAACGAGTATCTTATATTTCAGAAGATCATTAAGTTGGAATATGACTTTCCAGAAAAATTCTTCCCTAAGGCAAGAGACCTCG TGGAGAAACTTTTGGTTTTAGATGCCACAAAGCGGTTAGGCTGTGAGGAAATGGAAGGATACGGACCTCTTAAAGCACACCCGTTCTTCGAGTCCGTCAC GTGGGAGAACCTGCACCAGCAGACGCCTCCGAAGCTCACCGCTTACCTGCCGGCTATGTCGGAAGACGACGAGGACTGCTATGGCAATTATGACAATCTC CTGAGCCAGTTTGGCTGCATGCAGGTGTCTTCGTCCTCCTCCTCACACTCCCTGTCAGCCTCCGACACGGGCCTGCCCCAGAGGTCAGGCAGCAACATAG AGCAGTACATTCACGATCTGGACTCGAACTCCTTTGAACTGGACTTACAGTTTTCCGAAGATGAGAAGAGGTTGTTGTTGGAGAAGCAGGCTGGCGGAAA CCCTTGGCACCAGTTTGTAGAAAATAATTTAATACTAAAGATGGGCCCAGTGGATAAGCGGAAGGGTTTATTTGCAAGACGACGACAGCTGTTGCTCACA GAAGGACCACATTTATATTATGTGGATCCTGTCAACAAAGTTCTGAAAGGTGAAATTCCTTGGTCACAAGAACTTCGACCAGAGGCCAAGAATTTTAAAA CTTTCTTTGTCCACACGCCTAACAGGACGTATTATCTGATGGACCCCAGCGGGAACGCACACAAGTGGTGCAGGAAGATCCAGGAGGTTTGGAGGCAGCG ATACCAGAGCCACCCGGACGCCGCTGTGCAGTGACGTGGCCTGCGGCCGGGCTGCCCTTCGCTGCCAGGACACCTGCCCCAGCGCGGCTTGGCCGCCATC CGGGACGCTTCCAGACCACCTGCCAGCCATCACAAGGGGAACGCAGAGGCGGAAACCTTGCAGCATTTTTATTTAAAAGAAAAGAAGAAAAAAAACACCC AACCACACAAAGAACAAAACCAGTAACAAACACAAAGGAATTCAGGGTCGCTTTGCTTGCTCTCTGTGCTCCGTGGAGGCCTCCGTGTGCCCTCGTTGCC GTGGGGACCCAGCTCCATGCACGTCAACCCAGTCCCGCCCAGACTAGTGGACAGACCTGGTGTCACCAGTTTTTCCTAGCATCAGTCCGAACCATGCGCC CGCCCTGCCCCAACTGTGTGCTGGTCCTGCTGTGGCCGAGGGGACCGGGTGTGTTTGGCTCTTTATGCCCCTCCCGCTGTGGTCCTGGAACTCTTCACCA GGGAGGGAGCCCTGCGGGGGCCGCAGCTTTGTGGAGGGAGCCGCCGTGCTTCTGTCACCTGCTCCCTTTCTTGCGTCTCCCTGTGATGGGCCCTTAGGCC TGGCTGGGCCCATTACATATCCCTGTGGTGGCTCTGGTGGCAGCTTTCTGTGGCCCCTGCTGTGTTGGCAGGCAGGTTTGCGTGGTGAGGAGCGGGAGGG GTTGGAGTGGTGCGGGAGCAGGCTGCCGAGTGGAGGGTGCCATCGAGGGCTCCGGATCCCTTATCCTACTTAGCAGTGTTGGTCTCTGGGGCTGGAAGCC GAGCGCATGCTGGGAGCGGTACTGTCAGAAGTGAGCCCAGTTAGTACCCCGCTGGCTCACTGCACGAGAGAGTCCTGCCCCGAGCCCTAGGTGGGGCCAG GAGGTGCCTTGGAGAAGCCAGCCAGAGCAGAGAGGGCTGCTGACTTCCGTGTGGAGCAGAGAGGCCTGAGGGCCTCCTAAAAGGTTTAAATGTCCACGCC TCTCCAGTTGCTGAAGTAGGGTCTGAGAGAACCCTGGCATCAGCAGACCCAGGGTGCTTCTGTCTCCTGCAGACCACGCCAGGGAGTGCAGACACCACCG TCACACACGCCCCTTTTGTGTTTTGGTTCAAGTTTCTCAGAGCCCCTCAGAGCTTCTACATCTGTGCATCAGAAATCTCACAGCCTTCTCATGCTGCCGG CTCATCTGGGCCCATAGAGTGGGCTTTGCCAGTTGCTGTTGCACAGGAGGCGAGAACAGCACACTTCAACCCCAGCTTGCTGGTCGGCTTTCCTCTAGAG AGAGCCGGTTTTGGGGCCATTTCCCTTTGATGCTTTGGTGGCCTTGCCCCGCTCTGCAGCACAGACAGGCCAGATGCATTTGTCCTTTGCCTAGCTACTC CCCAGGTAGAGAGTGCTCCTGGTGGCCTGGCAGGTCTGGGCCCTTCTCTCCCTGCCCAGGTTGTCCCTGGAGGGCAGCCCTCACTCCCTTTGGGGGAGAG GCAGACATTGCTGCCCACAGACCTGCCTCTGACTCAACTGTGTCCACCCTCCCTGGTCCCTACCCCCAAGTCACAGGTGACTCAGCAGTGACCCTGTGTG CCAGGCCAGATCCAAACTGAGAGGGAAGGTGTCGTTTTTACACTGCTAATGACGAGAGTGGCTCTTTTTAGCTAGGCGAGTACAGACGGGGCCTGGGAGG GGGCAGAGATGTTCCCCAGGCCCTGCCTGTGGTTCCTGCCTGGGCCTTGGCTGCTGCTGTGTGAGAGCTGCATGTGAGCCTGTGACCGTGAGCTGGGGTG AGCTGGGCCGCACCTACCCTGGGGCCCCAGGGAGCAGGACGCTCCGGGGCCCAGCACGTTGCCCTGGGCCTGTGGCCGGAGTCGGAGTCCTCTCTCCTCC TCCTGGCTTTTGGAAAGGCTTGGCTGTGTTGGGGAGTCTCTCTTAGCCCTTTCAGGAATTTCTGTTCAGGCTTCCTCCTCCTCATCAGCTATTTTACCCA TCTCAGAACGTCCTGTGTCTCCATGTAGGAGAGTGGCTCTCTCAGATCTCTCAGGGCGTCTGGTTATAGGGAAACAAGTGGAGCAGGGACGTGGCTTTAA TTGGAGCACTCGGCTGGGCTGCTTGGGGAGACTCTTCCGTGCGTTCTTCCTCTGGATAGAACCACCACCTCCTGGGCGTCACTGACAAGCTCCATCTTAA CCTCCAAAGCCACAGAACTAGGGGCTCAGAGCCAGAGCTGGCAGCCGCCAGCCAAAATGATGCCATTGCCTGAGCTGACAGCCAAGCCCTTCTGTGGGTC ACCTTTCTCCTCACCCAGCCCCTTGCTCTTCCCTTTTGAAAGGCCCGTGTGTTTTCTTTCCTTACCCTGTGCTTGCTCATGTCTACTCCGGTTTTCTCTA CCACATCCTTAGAGCCATCACCTGGCACGCAGGCGCCTTACATTCTACGGTAGAACGTGGGGTACTGTGTGTGCACATAGACACACTTACGTGGAATTAC AGTTGTGGGTTTATCCAAGATGAGGAAGATTTCACCTGCTGTTTAATAGACTTGGGGCCATGTGCCTCCCCACACATGGGCAAGGACAGGTGGAATGTCG GGACCACACTGTGCGGCTTCTCGGCACAAAGCGGAGGGAGGCTGTGGTCGCTGCCGGCCTAGGTGTCCCAGGTGCCCCGCCTTTCTCTGGGACACAGTTG GGGGCTGGCTTCTGAGGGATTCCTTTCTCCCCTCTTTGTGTGGCCCCAGCCAGGGCGGTGGGCAGTCCTGGTGTAGAGCACAAGCCTCTCCACCCTAGAG AAATGCCTCTGTACCACGGCTACCATGTGGAACCTTAACTTGCAGAAGGCTTGTTAACAATTGTTTTGAGAGAGATGGCTGGTCATGCCACAGCTGCTGG GGACTCCGCCTACTCCAGCCCTCTTGGGACACACTGTGGGATTTGTGGCCCTTCCCCAGAGGAATTGTGGAGACTGTCCCATGGAACAAACCCTCAGGCA CCAGCACAGGGCTCTGGGTGACTCAGTAAAACTAACGTTTGTCTCTGACAAGATCAGCTGTAGGCTCACCGGCCAGAGAAGACCACTGTGAGCATTTTGC CGTATATCCTGCCCTGCCATTTGTTCACTTTTTAAACTAAAATAGGAACATCCGACACACACCGTTTGCATCGTCTTCTCCCTTGATATTTTAAGCATTT TCCCATGTCATGAGTTTCTCAGAAACATGTTTTTAACAATTGTACTATTTAGTCATTGTCCATTTACTATAATTTATCTGACCATTTCCCTACTGTAAAA TACTTAAGACGGTTTCTGATTTTTCCACTATTTAAATAATGCTGTGATGAATATCTTTAAAATCTTCTGATTTCTTACTTTTTTCCCCCTTAGATGCCTG GAAGTGGTATTTTGAGGTGAAAGAGTTTGTTCATTTTGAAGATATTTCTGTCTCTCTCTCGACCTGATGTGTAGACGCTCACTTCCAGTAGCAGAACCAC CTTAGTTGTGTCTTACAGATTCTGAACAAATCGGTTTCTGATAAGCCATGTGTTCCAAAGAATGTCTGAATAAGACCGCTCTTTATTTAAATGCTAAGAG GATGTCACTACTGCAATCCATCTGTGGCCGATTTTTTCCAAGAGCCAATTTCCTTGTTTTGGTTGCAAGAACCTGGCTCTGCCTGCATGTCAGCTCTCTG CCCTCCCTGCTGCCGTGGCTTTCAAGCGCTTGGCAGAATCTTGTACTTCGTGTCCACAATGGTACTGAATTTGCATCTGCACAGTCAGCAGAGATAACAA GTGTTGAACTGACCTTGCCACATGCTTAGTGAGTGATTTGTAATTAAGTTTATAGACTCAGAAGGTATATTAGGACATTTGGAATCAGTAGCAGAGCAAA GCCTCTTTGAAAAAAACCACGTAGCTGATTGGGTTTTACAAGAGTGCATTTGTCTCCCCCTTCCACCCGTGGGGCCCCACCTTCAGGTCTTAGTGGTTCA CAAGAGCCCAGCAGCCAGGCTGGCTTTTTCATTGTAGGGCGTGGTTGTCCCAGCTGGTGTAGATTTCAGGCCGCCCCCCCCAACTCCCTGCCCACAGTGT TGCAGATTGCCTGGCTGGCAGCAAGTCCAGACCACCCAAATTTGGTTGGATTCTTCATTTCTCCACTGTAGTTGGGGTCCATTGATTGTGCAGGGGAACG TGCAGGAGGTTTTTCTAGGCACCGTGTTCAGTGCTGCTTCACTCTACCAGAGATTATGGCCAAATTGCACGGAATTTGGTTTCTTGCCCTCTGAAGCCTG AGGGCCCCCCCTTGCCTGGCTGGTTGACAGACCCGGGGTGGTCACTGCTGAGACTTCAGAGATCGCAGCTGCTGTGAGAATACGGTGAAGGTACTTTGTT CTGGAAGATGTTGTCATACACTTTTCCCCAGTTATTTTCAAACTTGACATGAGCCTATGTTGACTCACTGGGTGGGGGTCCCTTCTTACGCAGCACACGT GGCAAGTGCCTGAATCGGGGCTGGAGGCACTTCAGAGCCTCTGAGGGGCCACCACTTCTGGCCCAAAATTGCAGGGTTGTAGATGAGGCTGCCTGTGGAG AACTGGTGTGAGGAGGAAGCTGTTTCCAACAAAGAGCACTTTCATCTGTTGAGATGGCTGTGGTGAGCAACTGAACGAGCCTACGTGTGTACCTGAATTT TCCCCGTAACTCATTTCTTCCATATGAAGAAACACCAAACTATGTACAGAGAACTTTTTACAAAAGGCAGACCTTTTTTAAGCTGTGTAACCCACATAGC CTAACCACCTGGCAGAATGACTACGAATAGGGGTCATTGTGCTGGTAAAAGCCTCTATTACGACTGTAAGTAAGTTGGATGTTGGCAAAATTAAATTGTT ACAGTATTTAGAGCTGCTGTAGCTGTTCCTTCACAACATAAAATAGGATAAATGACTAGTACGTCTTTCAGGTGGGTGGCAAGCAGAACATGCGTAATAT TCTCTACCTGGTCTGTAGCTGTAACTGTGATGTACAGACAAAGCAAAAATTAAAAGAACTTATGAAAACAAATGCAATGATACTAGGATATACACTTTTG TATTTTTATTCTTATATAAGGTTATTTGCTGGCTATTGTTGGCCTCTAGTTCAGTCTGTGTTATTTAAATTCTAATATATGAATTATTTGAATTGAATTC ATGTTCGGGGCCACGTTGTTGTATGTATTGATGTACAGCCTTGAATGTGAATAATTATTGTAAACTATATTTTACAACTTTTTTTCTGGCTTTATTATAT AAATTTTCTATTGGGTCAGTGATTTAATCATATAATTTAATGAATCTGTTTATCCTTTTTTTTTTTCCAAATACTTGTGCTTTAGGTGTAGTTACCAGAT GATGAATTTTCCTCGTATGGTCAGTAGTCTTGTAATAAAAAGCATGTAGAGTGTA

refseq_PDPK1.F1 (forward primer)
refseq_PDPK1.R1 (reverse primer)
Multiple exon skipping

Frame 0

AGGGGRRATGRAQDEGGHCWGSASGRRTLRRRR AAQRCGGGARADAGPMARTTSQLYDAVPIQSSVV LCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMD GTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFG KILGEGSFSTVVLARELATSREYATRANSFVGTA QYVSPELLTEKSACKSSDLWALGCIIYQLVAGL PPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDL VEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVT WENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNL LSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNI EQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGN PWHQFVENNLILKMGPVDKRKGLFARRRQLLLT EGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFK TFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQR YQSHPDAAVQ*RGLRPGCPSLPGHLPQRGLAAI RDASRPPASHHKGNAEAETLQHFYLKEKKKKNT QPHKEQNQ*QTQRNSGSLCLLSVLRGGLRVPSLP WGPSSMHVNPVPPRLVDRPGVTSFS*HQSEPCA RPAPTVCWSCCGRGDRVCLALYAPPAVVLELFT REGALRGPQLCGGSRRASVTCSLSCVSL*WALRP GWAHYISLWWLWWQLSVAPAVLAGRFAW*GAGG VGVVREQAAEWRVPSRAPDPLSYLAVLVSGAGS RAHAGSGTVRSEPS*YPAGSLHERVLPRALGGAR RCLGEASQSREGC*LPCGAERPEGLLKGLNVHA SPVAEVGSERTLASADPGCFCLLQTTPGSADTT VTHAPFVFWFKFLRAPQSFYICASEISQPSHAAG SSGPIEWALPVAVAQEARTAHFNPSLLVGFPLE RAGFGAISL*CFGGLAPLCSTDRPDAFVLCLAT PQVESAPGGLAGLGPSLPAQVVPGGQPSLPLGER QTLLPTDLPLTQLCPPSLVPTPKSQVTQQ*PCV PGQIQTEREGVVFTLLMTRVALFS*ASTDGAWE GAEMFPRPCLWFLPGPWLLLCESCM*ACDRELG* AGPHLPWGPREQDAPGPSTLPWACGRSRSPLSS SWLLERLGCVGESLLALSGISVQASSSSSAILP ISERPVSPCRRVALSDLSGRLVIGKQVEQGRGFN WSTRLGCLGRLFRAFFLWIEPPPPGRH*QAPS* PPKPQN*GLRARAGSRQPK*CHCLS*QPSPSVG HLSPHPAPCSSLLKGPCVFFPYPVLAHVYSGFLY HILRAITWHAGALHSTVERGVLCVHIDTLTWNY SCGFIQDEEDFTCCLIDLGPCASPHMGKDRWNV GTTLCGFSAQSGGRLWSLPA*VSQVPRLSLGHSW GLASEGFLSPLFVWPQPGRWAVLV*STSLSTLE KCLCTTATMWNLNLQKAC*QLF*ERWLVMPQLL GTPPTPALLGHTVGFVALPQRNCGDCPMEQTLRH QHRALGDSVKLTFVSDKISCRLTGQRRPL*AFC RISCPAICSLFKLK*EHPTHTVCIVFSLDILSI FPCHEFLRNMFLTIVLFSHCPFTIIYLTISLL*N T*DGF*FFHYLNNAVMNIFKIF*FLTFFPLRCL EVVF*GERVCSF*RYFCLSLDLMCRRSLPVAEP P*LCLTDSEQIGF**AMCSKECLNKTALYLNAKR MSLLQSICGRFFPRANFLVLVARTWLCLHVSSL PSLLPWLSSAWQNLVLRVHNGTEFASAQSAEIT SVELTLPHA**VICN*VYRLRRYIRTFGISSRAK PL*KKPRS*LGFTRVHLSPPSTRGAPPSGLSGS QEPSSQAGFFIVGRGCPSWCRFQAAPPNSLPTV LQIAWLAASPDHPNLVGFFISPL*LGSIDCAGER AGGFSRHRVQCCFTLPEIMAKLHGIWFLAL*SL RAPPCLAG*QTRGGHC*DFRDRSCCENTVKVLC SGRCCHTLFPSYFQT*HEPMLTHWVGVPSYAAHV ASA*IGAGGTSEPLRGHHFWPKIAGL*MRLPVE NWCEEEAVSNKEHFHLLRWLW*ATERAYVCT*I FPVTHFFHMKKHQTMYRELFTKGRPFLSCVTHIA *PPGRMTTNRGHCAGKSLYYDCK*VGCWQN*IV TVFRAAVAVPSQHKIG*MTSTSFRWVASRTCVI FSTWSVAVTVMYRQSKN*KNL*KQMQ*Y*DIHFC IFILI*GYLLAIVGL*FSLCYLNSNI*II*IEF MFGATLLYVLMYSLECE*LL*TIFYNFFSGFII *IFYWVSDLII*FNESVYPFFFSKYLCFRCSYQM MNFPRMVSSLVIKSM*SV

Frame 1

PGAGGGGRRGGRRMRAAIAGAPLRGGGR*GGAE PRSAAGEAPAPTRGPWPGPPASCMTPCPSSPAW CYVPAHPHQW*GPRLSPARPLAFLVAAGRAPPWT ALQPSLGPAPAPCSMPSLRRSLGRSGLRTSSLG KSLGKALFPRLSWLENWQPPENMRPGPTHSWEQ RSTFLQSCSRRSPPVRVQTFGLLDA*YTSLWQDS HHSELETSILYFRRSLSWNMTFQKNSSLRQETS WRNFWF*MPQSG*AVRKWKDTDLLKHTRSSSPS RGRTCTSRRLRSSPLTCRLCRKTTRTAMAIMTIS *ASLAACRCLRPPPHTPCQPPTRACPRGQAAT* SSTFTIWTRTPLNWTYSFPKMRRGCCWRSRLAE TLGTSL*KII*Y*RWAQWISGRVYLQDDDSCCSQ KDHIYIMWILSTKF*KVKFLGHKNFDQRPRILK LSLSTRLTGRII*WTPAGTHTSGAGRSRRFGGS DTRATRTPLCSDVACGRAALRCQDTCPSAAWPPS GTLPDHLPAITRGTQRRKPCSIFI*KKRRKKTP NHTKNKTSNKHKGIQGRFACSLCSVEASVCPRC RGDPAPCTSTQSRPD*WTDLVSPVFPSISPNHAP ALPQLCAGPAVAEGTGCVWLFMPLPLWSWNSSP GREPCGGRSFVEGAAVLLSPAPFLASPCDGPLG LAGPITYPCGGSGGSFLWPLLCWQAGLRGEEREG LEWCGSRLPSGGCHRGLRIPYPT*QCWSLGLEA ERMLGAVLSEVSPVSTPLAHCTRESCPEP*VGP GGALEKPARAERAADFRVEQRGLRAS*KV*MSTP LQLLK*GLREPWHQQTQGASVSCRPRQGVQTPP SHTPLLCFGSSFSEPLRASTSVHQKSHSLLMLP AHLGP*SGLCQLLLHRRREQHTSTPACWSAFL*R EPVLGPFPFDALVALPRSAAQTGQMHLSFA*LL PR*RVLLVAWQVWALLSLPRLSLEGSPHSLWGR GRHCCPQTCL*LNCVHPPWSLPPSHR*LSSDPVC QARSKLRGKVSFLHC**REWLFLARRVQTGPGR GQRCSPGPACGSCLGLGCCCVRAACEPVTVSWG ELGRTYPGAPGSRTLRGPARCPGPVAGVGVLSPP PGFWKGLAVLGSLS*PFQEFLFRLPPPHQLFYP SQNVLCLHVGEWLSQISQGVWL*GNKWSRDVAL IGALGWAAWGDSSVRSSSG*NHHLLGVTDKLHLN LQSHRTRGSEPELAAASQNDAIA*ADSQALLWV TFLLTQPLALPF*KARVFSFLTLCLLMSTPVFS TTSLEPSPGTQAPYILR*NVGYCVCT*THLRGIT VVGLSKMRKISPAV**TWGHVPPHTWARTGGMS GPHCAASRHKAEGGCGRCRPRCPRCPAFLWDTV GGWLLRDSFLPSLCGPSQGGGQSWCRAQASPP*R NASVPRLPCGTLTCRRLVNNCFERDGWSCHSCW GLRLLQPSWDTLWDLWPFPRGIVETVPWNKPSG TSTGLWVTQ*N*RLSLTRSAVGSPAREDHCEHFA VYPALPFVHFLN*NRNIRHTPFASSSPLIF*AF SHVMSFSETCF*QLYYLVIVHLL*FI*PFPYCK ILKTVSDFSTI*IML**ISLKSSDFLLFSPLDAW KWYFEVKEFVHFEDISVSLST*CVDAHFQ*QNH LSCVLQILNKSVSDKPCVPKNV*IRPLFI*MLR GCHYCNPSVADFFQEPISLFWLQEPGSACMSALC PPCCRGFQALGRILYFVSTMVLNLHLHSQQR*Q VLN*PCHMLSE*FVIKFIDSEGILGHLESVAEQ SLFEKNHVADWVLQECICLPLPPVGPHLQVLVVH KSPAARLAFSL*GVVVPAGVDFRPPPPTPCPQC CRLPGWQQVQTTQIWLDSSFLHCSWGPLIVQGN VQEVFLGTVFSAASLYQRLWPNCTEFGFLPSEA* GPPLAWLVDRPGVVTAETSEIAAAVRIR*RYFV LEDVVIHFSPVIFKLDMSLC*LTGWGSLLTQHT WQVPESGLEALQSL*GATTSGPKLQGCR*GCLWR TGVRRKLFPTKSTFIC*DGCGEQLNEPTCVPEF SP*LISSI*RNTKLCTENFLQKADLF*AV*PT* PNHLAE*LRIGVIVLVKASITTVSKLDVGKIKLL QYLELL*LFLHNIK*DK*LVRLSGGWQAEHA*Y SLPGL*L*L*CTDKAKIKRTYENKCNDTRIYTF VFLFLYKVICWLLLASSSVCVI*ILIYELFELNS CSGPRCCMY*CTALNVNNYCKLYFTTFFLALLY KFSIGSVI*SYNLMNLFILFFFPNTCALGVVTR **IFLVWSVVL**KACRV

Frame 2

RGRGAAGDGAGAG*GRPLLGLRFGEEDAEEAPS RAALRGRRPRRRGAHGQDHQPAV*RRAHPVQRG VMFLPIPINGEDPD*VQHAPWHSWWQQAGPRHG RHCSRASARRRLPAACPASAAASEEAA*GLQVWE NPWGRLFFHGCPGSRTGNLQRICDQGQLIRGNS AVRFSRAAHGEVRL*EFRPLGSWMHNIPACGRT PTIPSWKRVSYISEDH*VGI*LSRKILP*GKRPR GETFGFRCHKAVRL*GNGRIRTS*STPVLRVRH VGEPAPADASEAHRLPAGYVGRRRGLLWQL*QS PEPVWLHAGVFVLLLTLPVSLRHGPAPEVRQQHR AVHSRSGLELL*TGLTVFRR*EEVVVGEAGWRK PLAPVCRK*FNTKDGPSG*AEGFICKTTTAVAH RRTTFILCGSCQQSSER*NSLVTRTSTRGQEF*N FLCPHA*QDVLSDGPQRERTQVVQEDPGGLEAA IPEPPGRRCAVTWPAAGLPFAARTPAPARLGRH PGRFQTTCQPSQGERRGGNLAAFLFKRKEEKKHP TTQRTKPVTNTKEFRVALLALCAPWRPPCALVA VGTQLHARQPSPAQTSGQTWCHQFFLASVRTMR PPCPNCVLVLLWPRGPGVFGSLCPSRCGPGTLHQ GGSPAGAAALWREPPCFCHLLPFLRLPVMGP*A WLGPLHIPVVALVAAFCGPCCVGRQVCVVRSGR GWSGAGAGCRVEGAIEGSGSLILLSSVGLWGWKP SACWERYCQK*AQLVPRWLTARESPAPSPRWGQ EVPWRSQPEQRGLLTSVWSREA*GPPKRFKCPR LSSC*SRV*ENPGISRPRVLLSPADHARECRHHR HTRPFCVLVQVSQSPSELLHLCIRNLTAFSCCR LIWAHRVGFASCCCTGGENSTLQPQLAGRLSSR ESRFWGHFPLMLWWPCPALQHRQARCICPLPSYS PGRECSWWPGRSGPFSPCPGCPWRAALTPFGGE ADIAAHRPASDSTVSTLPGPYPQVTGDSAVTLC ARPDPN*EGRCRFYTANDESGSF*LGEYRRGLGG GRDVPQALPVVPAWALAAAV*ELHVSL*P*AGV SWAAPTLGPQGAGRSGAQHVALGLWPESESSLL LLAFGKAWLCWGVSLSPFRNFCSGFLLLISYFTH LRTSCVSM*ESGSLRSLRASGYRETSGAGTWL* LEHSAGLLGETLPCVLPLDRTTTSWASLTSSIL TSKATELGAQSQSWQPPAKMMPLPELTAKPFCGS PFSSPSPLLFPFERPVCFLSLPCACSCLLRFSL PHP*SHHLARRRLTFYGRTWGTVCAHRHTYVEL QLWVYPR*GRFHLLFNRLGAMCLPTHGQGQVECR DHTVRLLGTKRREAVVAAGLGVPGAPPFSGTQL GAGF*GIPFSPLCVAPARAVGSPGVEHKPLHPR EMPLYHGYHVEP*LAEGLLTIVLREMAGHATAAG DSAYSSPLGTHCGICGPSPEELWRLSHGTNPQA PAQGSG*LSKTNVCL*QDQL*AHRPEKTTVSIL PYILPCHLFTF*TKIGTSDTHRLHRLLP*YFKHF PMS*VSQKHVFNNCTI*SLSIYYNLSDHFPTVK YLRRFLIFPLFK*CCDEYL*NLLISYFFPP*MP GSGILR*KSLFILKIFLSLSRPDV*TLTSSSRTT LVVSYRF*TNRFLISHVFQRMSE*DRSLFKC*E DVTTAIHLWPIFSKSQFPCFGCKNLALPACQLS ALPAAVAFKRLAESCTSCPQWY*ICICTVSRDNK C*TDLATCLVSDL*LSL*TQKVY*DIWNQ*QSK ASLKKTT*LIGFYKSAFVSPFHPWGPTFRS*WF TRAQQPGWLFHCRAWLSQLV*ISGRPPQLPAHSV ADCLAGSKSRPPKFGWILHFSTVVGVH*LCRGT CRRFF*APCSVLLHSTRDYGQIARNLVSCPLKP EGPPLPGWLTDPGWSLLRLQRSQLL*EYGEGTLF WKMLSYTFPQLFSNLT*AYVDSLGGGPFLRSTR GKCLNRGWRHFRASEGPPLLAQNCRVVDEAACG ELV*GGSCFQQRALSSVEMAVVSN*TSLRVYLNF PRNSFLPYEETPNYVQRTFYKRQTFFKLCNPHS LTTWQNDYE*GSLCW*KPLLRL*VSWMLAKLNC YSI*SCCSCSFTT*NRIND*YVFQVGGKQNMRNI LYLVCSCNCDVQTKQKLKELMKTNAMILGYTLL YFYSYIRLFAGYCWPLVQSVLFKF*YMNYLN*I HVRGHVVVCIDVQP*M*IIIVNYILQLFFWLYYI NFLLGQ*FNHII**ICLSFFFFQILVL*V*LPD DEFSSYGQ*SCNKKHVEC

Sequence NM_002613

GCCGGGGGCGGGGGGCGGCGGGCGACGGGGCGGGCGCAGGATGAGGGCGGCCATTGCTGGGGCTCCGCTTCGGGGAGGAGGACGCTGAGGAGGCGCCGAG CCGCGCAGCGCTGCGGGGGAGGCGCCCGCGCCGACGCGGGGCCCATGGCCAGGACCACCAGCCAGCTGTATGACGCCGTGCCCATCCAGTCCAGCGTGGT GTTATGTTCCTGCCCATCCCCATCAATGGTGAGGACCCAGACTGAGTCCAGCACGCCCCCTGGCATTCCTGGTGGCAGCAGGCAGGGCCCCGCCATGGAC GGCACTGCAGCCGAGCCTCGGCCCGGCGCCGGCTCCCTGCAGCATGCCCAGCCTCCGCCGCAGCCTCGGAAGAAGCGGCCTGAGGACTTCAAGTTTGGGA AAATCCTTGGGGAAGGCTCTTTTTCCACGGTTGTCCTGGCTCGAGAACTGGCAACCTCCAGAGAATATGCGATTAAAATTCTGGAGAAGCGACATATCAT AAAAGAGAACAAGGTCCCCTATGTAACCAGAGAGCGGGATGTCATGTCGCGCCTGGATCACCCCTTCTTTGTTAAGCTTTACTTCACATTTCAGGACGAC GAGAAGCTGTATTTCGGCCTTAGTTATGCCAAAAATGGAGAACTACTTAAATATATTCGCAAAATCGGTTCATTCGATGAGACCTGTACCCGATTTTACA CGGCTGAGATTGTGTCTGCTTTAGAGTACTTGCACGGCAAGGGCATCATTCACAGGGACCTTAAACCGGAAAACATTTTGTTAAATGAAGATATGCACAT CCAGATCACAGATTTTGGAACAGCAAAAGTCTTATCCCCAGAGAGCAAACAAGCCAGGGCCAACTCATTCGTGGGAACAGCGCAGTACGTTTCTCCAGAG CTGCTCACGGAGAAGTCCGCCTGTAAGAGTTCAGACCTTTGGGCTCTTGGATGCATAATATACCAGCTTGTGGCAGGACTCCCACCATTCCGAGCTGGAA ACGAGTATCTTATATTTCAGAAGATCATTAAGTTGGAATATGACTTTCCAGAAAAATTCTTCCCTAAGGCAAGAGACCTCGTGGAGAAACTTTTGGTTTT AGATGCCACAAAGCGGTTAGGCTGTGAGGAAATGGAAGGATACGGACCTCTTAAAGCACACCCGTTCTTCGAGTCCGTCACGTGGGAGAACCTGCACCAG CAGACGCCTCCGAAGCTCACCGCTTACCTGCCGGCTATGTCGGAAGACGACGAGGACTGCTATGGCAATTATGACAATCTCCTGAGCCAGTTTGGCTGCA TGCAGGTGTCTTCGTCCTCCTCCTCACACTCCCTGTCAGCCTCCGACACGGGCCTGCCCCAGAGGTCAGGCAGCAACATAGAGCAGTACATTCACGATCT GGACTCGAACTCCTTTGAACTGGACTTACAGTTTTCCGAAGATGAGAAGAGGTTGTTGTTGGAGAAGCAGGCTGGCGGAAACCCTTGGCACCAGTTTGTA GAAAATAATTTAATACTAAAGATGGGCCCAGTGGATAAGCGGAAGGGTTTATTTGCAAGACGACGACAGCTGTTGCTCACAGAAGGACCACATTTATATT ATGTGGATCCTGTCAACAAAGTTCTGAAAGGTGAAATTCCTTGGTCACAAGAACTTCGACCAGAGGCCAAGAATTTTAAAACTTTCTTTGTCCACACGCC TAACAGGACGTATTATCTGATGGACCCCAGCGGGAACGCACACAAGTGGTGCAGGAAGATCCAGGAGGTTTGGAGGCAGCGATACCAGAGCCACCCGGAC GCCGCTGTGCAGTGACGTGGCCTGCGGCCGGGCTGCCCTTCGCTGCCAGGACACCTGCCCCAGCGCGGCTTGGCCGCCATCCGGGACGCTTCCAGACCAC CTGCCAGCCATCACAAGGGGAACGCAGAGGCGGAAACCTTGCAGCATTTTTATTTAAAAGAAAAGAAGAAAAAAAACACCCAACCACACAAAGAACAAAA CCAGTAACAAACACAAAGGAATTCAGGGTCGCTTTGCTTGCTCTCTGTGCTCCGTGGAGGCCTCCGTGTGCCCTCGTTGCCGTGGGGACCCAGCTCCATG CACGTCAACCCAGTCCCGCCCAGACTAGTGGACAGACCTGGTGTCACCAGTTTTTCCTAGCATCAGTCCGAACCATGCGCCCGCCCTGCCCCAACTGTGT GCTGGTCCTGCTGTGGCCGAGGGGACCGGGTGTGTTTGGCTCTTTATGCCCCTCCCGCTGTGGTCCTGGAACTCTTCACCAGGGAGGGAGCCCTGCGGGG GCCGCAGCTTTGTGGAGGGAGCCGCCGTGCTTCTGTCACCTGCTCCCTTTCTTGCGTCTCCCTGTGATGGGCCCTTAGGCCTGGCTGGGCCCATTACATA TCCCTGTGGTGGCTCTGGTGGCAGCTTTCTGTGGCCCCTGCTGTGTTGGCAGGCAGGTTTGCGTGGTGAGGAGCGGGAGGGGTTGGAGTGGTGCGGGAGC AGGCTGCCGAGTGGAGGGTGCCATCGAGGGCTCCGGATCCCTTATCCTACTTAGCAGTGTTGGTCTCTGGGGCTGGAAGCCGAGCGCATGCTGGGAGCGG TACTGTCAGAAGTGAGCCCAGTTAGTACCCCGCTGGCTCACTGCACGAGAGAGTCCTGCCCCGAGCCCTAGGTGGGGCCAGGAGGTGCCTTGGAGAAGCC AGCCAGAGCAGAGAGGGCTGCTGACTTCCGTGTGGAGCAGAGAGGCCTGAGGGCCTCCTAAAAGGTTTAAATGTCCACGCCTCTCCAGTTGCTGAAGTAG GGTCTGAGAGAACCCTGGCATCAGCAGACCCAGGGTGCTTCTGTCTCCTGCAGACCACGCCAGGGAGTGCAGACACCACCGTCACACACGCCCCTTTTGT GTTTTGGTTCAAGTTTCTCAGAGCCCCTCAGAGCTTCTACATCTGTGCATCAGAAATCTCACAGCCTTCTCATGCTGCCGGCTCATCTGGGCCCATAGAG TGGGCTTTGCCAGTTGCTGTTGCACAGGAGGCGAGAACAGCACACTTCAACCCCAGCTTGCTGGTCGGCTTTCCTCTAGAGAGAGCCGGTTTTGGGGCCA TTTCCCTTTGATGCTTTGGTGGCCTTGCCCCGCTCTGCAGCACAGACAGGCCAGATGCATTTGTCCTTTGCCTAGCTACTCCCCAGGTAGAGAGTGCTCC TGGTGGCCTGGCAGGTCTGGGCCCTTCTCTCCCTGCCCAGGTTGTCCCTGGAGGGCAGCCCTCACTCCCTTTGGGGGAGAGGCAGACATTGCTGCCCACA GACCTGCCTCTGACTCAACTGTGTCCACCCTCCCTGGTCCCTACCCCCAAGTCACAGGTGACTCAGCAGTGACCCTGTGTGCCAGGCCAGATCCAAACTG AGAGGGAAGGTGTCGTTTTTACACTGCTAATGACGAGAGTGGCTCTTTTTAGCTAGGCGAGTACAGACGGGGCCTGGGAGGGGGCAGAGATGTTCCCCAG GCCCTGCCTGTGGTTCCTGCCTGGGCCTTGGCTGCTGCTGTGTGAGAGCTGCATGTGAGCCTGTGACCGTGAGCTGGGGTGAGCTGGGCCGCACCTACCC TGGGGCCCCAGGGAGCAGGACGCTCCGGGGCCCAGCACGTTGCCCTGGGCCTGTGGCCGGAGTCGGAGTCCTCTCTCCTCCTCCTGGCTTTTGGAAAGGC TTGGCTGTGTTGGGGAGTCTCTCTTAGCCCTTTCAGGAATTTCTGTTCAGGCTTCCTCCTCCTCATCAGCTATTTTACCCATCTCAGAACGTCCTGTGTC TCCATGTAGGAGAGTGGCTCTCTCAGATCTCTCAGGGCGTCTGGTTATAGGGAAACAAGTGGAGCAGGGACGTGGCTTTAATTGGAGCACTCGGCTGGGC TGCTTGGGGAGACTCTTCCGTGCGTTCTTCCTCTGGATAGAACCACCACCTCCTGGGCGTCACTGACAAGCTCCATCTTAACCTCCAAAGCCACAGAACT AGGGGCTCAGAGCCAGAGCTGGCAGCCGCCAGCCAAAATGATGCCATTGCCTGAGCTGACAGCCAAGCCCTTCTGTGGGTCACCTTTCTCCTCACCCAGC CCCTTGCTCTTCCCTTTTGAAAGGCCCGTGTGTTTTCTTTCCTTACCCTGTGCTTGCTCATGTCTACTCCGGTTTTCTCTACCACATCCTTAGAGCCATC ACCTGGCACGCAGGCGCCTTACATTCTACGGTAGAACGTGGGGTACTGTGTGTGCACATAGACACACTTACGTGGAATTACAGTTGTGGGTTTATCCAAG ATGAGGAAGATTTCACCTGCTGTTTAATAGACTTGGGGCCATGTGCCTCCCCACACATGGGCAAGGACAGGTGGAATGTCGGGACCACACTGTGCGGCTT CTCGGCACAAAGCGGAGGGAGGCTGTGGTCGCTGCCGGCCTAGGTGTCCCAGGTGCCCCGCCTTTCTCTGGGACACAGTTGGGGGCTGGCTTCTGAGGGA TTCCTTTCTCCCCTCTTTGTGTGGCCCCAGCCAGGGCGGTGGGCAGTCCTGGTGTAGAGCACAAGCCTCTCCACCCTAGAGAAATGCCTCTGTACCACGG CTACCATGTGGAACCTTAACTTGCAGAAGGCTTGTTAACAATTGTTTTGAGAGAGATGGCTGGTCATGCCACAGCTGCTGGGGACTCCGCCTACTCCAGC CCTCTTGGGACACACTGTGGGATTTGTGGCCCTTCCCCAGAGGAATTGTGGAGACTGTCCCATGGAACAAACCCTCAGGCACCAGCACAGGGCTCTGGGT GACTCAGTAAAACTAACGTTTGTCTCTGACAAGATCAGCTGTAGGCTCACCGGCCAGAGAAGACCACTGTGAGCATTTTGCCGTATATCCTGCCCTGCCA TTTGTTCACTTTTTAAACTAAAATAGGAACATCCGACACACACCGTTTGCATCGTCTTCTCCCTTGATATTTTAAGCATTTTCCCATGTCATGAGTTTCT CAGAAACATGTTTTTAACAATTGTACTATTTAGTCATTGTCCATTTACTATAATTTATCTGACCATTTCCCTACTGTAAAATACTTAAGACGGTTTCTGA TTTTTCCACTATTTAAATAATGCTGTGATGAATATCTTTAAAATCTTCTGATTTCTTACTTTTTTCCCCCTTAGATGCCTGGAAGTGGTATTTTGAGGTG AAAGAGTTTGTTCATTTTGAAGATATTTCTGTCTCTCTCTCGACCTGATGTGTAGACGCTCACTTCCAGTAGCAGAACCACCTTAGTTGTGTCTTACAGA TTCTGAACAAATCGGTTTCTGATAAGCCATGTGTTCCAAAGAATGTCTGAATAAGACCGCTCTTTATTTAAATGCTAAGAGGATGTCACTACTGCAATCC ATCTGTGGCCGATTTTTTCCAAGAGCCAATTTCCTTGTTTTGGTTGCAAGAACCTGGCTCTGCCTGCATGTCAGCTCTCTGCCCTCCCTGCTGCCGTGGC TTTCAAGCGCTTGGCAGAATCTTGTACTTCGTGTCCACAATGGTACTGAATTTGCATCTGCACAGTCAGCAGAGATAACAAGTGTTGAACTGACCTTGCC ACATGCTTAGTGAGTGATTTGTAATTAAGTTTATAGACTCAGAAGGTATATTAGGACATTTGGAATCAGTAGCAGAGCAAAGCCTCTTTGAAAAAAACCA CGTAGCTGATTGGGTTTTACAAGAGTGCATTTGTCTCCCCCTTCCACCCGTGGGGCCCCACCTTCAGGTCTTAGTGGTTCACAAGAGCCCAGCAGCCAGG CTGGCTTTTTCATTGTAGGGCGTGGTTGTCCCAGCTGGTGTAGATTTCAGGCCGCCCCCCCCAACTCCCTGCCCACAGTGTTGCAGATTGCCTGGCTGGC AGCAAGTCCAGACCACCCAAATTTGGTTGGATTCTTCATTTCTCCACTGTAGTTGGGGTCCATTGATTGTGCAGGGGAACGTGCAGGAGGTTTTTCTAGG CACCGTGTTCAGTGCTGCTTCACTCTACCAGAGATTATGGCCAAATTGCACGGAATTTGGTTTCTTGCCCTCTGAAGCCTGAGGGCCCCCCCTTGCCTGG CTGGTTGACAGACCCGGGGTGGTCACTGCTGAGACTTCAGAGATCGCAGCTGCTGTGAGAATACGGTGAAGGTACTTTGTTCTGGAAGATGTTGTCATAC ACTTTTCCCCAGTTATTTTCAAACTTGACATGAGCCTATGTTGACTCACTGGGTGGGGGTCCCTTCTTACGCAGCACACGTGGCAAGTGCCTGAATCGGG GCTGGAGGCACTTCAGAGCCTCTGAGGGGCCACCACTTCTGGCCCAAAATTGCAGGGTTGTAGATGAGGCTGCCTGTGGAGAACTGGTGTGAGGAGGAAG CTGTTTCCAACAAAGAGCACTTTCATCTGTTGAGATGGCTGTGGTGAGCAACTGAACGAGCCTACGTGTGTACCTGAATTTTCCCCGTAACTCATTTCTT CCATATGAAGAAACACCAAACTATGTACAGAGAACTTTTTACAAAAGGCAGACCTTTTTTAAGCTGTGTAACCCACATAGCCTAACCACCTGGCAGAATG ACTACGAATAGGGGTCATTGTGCTGGTAAAAGCCTCTATTACGACTGTAAGTAAGTTGGATGTTGGCAAAATTAAATTGTTACAGTATTTAGAGCTGCTG TAGCTGTTCCTTCACAACATAAAATAGGATAAATGACTAGTACGTCTTTCAGGTGGGTGGCAAGCAGAACATGCGTAATATTCTCTACCTGGTCTGTAGC TGTAACTGTGATGTACAGACAAAGCAAAAATTAAAAGAACTTATGAAAACAAATGCAATGATACTAGGATATACACTTTTGTATTTTTATTCTTATATAA GGTTATTTGCTGGCTATTGTTGGCCTCTAGTTCAGTCTGTGTTATTTAAATTCTAATATATGAATTATTTGAATTGAATTCATGTTCGGGGCCACGTTGT TGTATGTATTGATGTACAGCCTTGAATGTGAATAATTATTGTAAACTATATTTTACAACTTTTTTTCTGGCTTTATTATATAAATTTTCTATTGGGTCAG TGATTTAATCATATAATTTAATGAATCTGTTTATCCTTTTTTTTTTTCCAAATACTTGTGCTTTAGGTGTAGTTACCAGATGATGAATTTTCCTCGTATG GTCAGTAGTCTTGTAATAAAAAGCATGTAGAGTGTA

refseq_PDPK1.F1 (forward primer)
refseq_PDPK1.R1 (reverse primer)
Multiple exon skipping

Frame 0

AGGGGRRATGRAQDEGGHCWGSASGRRTLRRRR AAQRCGGGARADAGPMARTTSQLYDAVPIQSSVV LCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMD GTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFG KILGEGSFSTVVLARELATSREYAIKILEKRHII KENKVPYVTRERDVMSRLDHPFFVKLYFTFQDD EKLYFGLSYAKNGELLKYIRKIGSFDETCTRFY TAEIVSALEYLHGKGIIHRDLKPENILLNEDMHI QITDFGTAKVLSPESKQARANSFVGTAQYVSPE LLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQ QTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGC MQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDL DSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFV ENNLILKMGPVDKRKGLFARRRQLLLTEGPHLY YVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTP NRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPD AAVQ*RGLRPGCPSLPGHLPQRGLAAIRDASRP PASHHKGNAEAETLQHFYLKEKKKKNTQPHKEQN Q*QTQRNSGSLCLLSVLRGGLRVPSLPWGPSSM HVNPVPPRLVDRPGVTSFS*HQSEPCARPAPTV CWSCCGRGDRVCLALYAPPAVVLELFTREGALRG PQLCGGSRRASVTCSLSCVSL*WALRPGWAHYI SLWWLWWQLSVAPAVLAGRFAW*GAGGVGVVRE QAAEWRVPSRAPDPLSYLAVLVSGAGSRAHAGSG TVRSEPS*YPAGSLHERVLPRALGGARRCLGEA SQSREGC*LPCGAERPEGLLKGLNVHASPVAEV GSERTLASADPGCFCLLQTTPGSADTTVTHAPFV FWFKFLRAPQSFYICASEISQPSHAAGSSGPIE WALPVAVAQEARTAHFNPSLLVGFPLERAGFGA ISL*CFGGLAPLCSTDRPDAFVLCLATPQVESAP GGLAGLGPSLPAQVVPGGQPSLPLGERQTLLPT DLPLTQLCPPSLVPTPKSQVTQQ*PCVPGQIQT EREGVVFTLLMTRVALFS*ASTDGAWEGAEMFPR PCLWFLPGPWLLLCESCM*ACDRELG*AGPHLP WGPREQDAPGPSTLPWACGRSRSPLSSSWLLER LGCVGESLLALSGISVQASSSSSAILPISERPVS PCRRVALSDLSGRLVIGKQVEQGRGFNWSTRLG CLGRLFRAFFLWIEPPPPGRH*QAPS*PPKPQN *GLRARAGSRQPK*CHCLS*QPSPSVGHLSPHPA PCSSLLKGPCVFFPYPVLAHVYSGFLYHILRAI TWHAGALHSTVERGVLCVHIDTLTWNYSCGFIQ DEEDFTCCLIDLGPCASPHMGKDRWNVGTTLCGF SAQSGGRLWSLPA*VSQVPRLSLGHSWGLASEG FLSPLFVWPQPGRWAVLV*STSLSTLEKCLCTT ATMWNLNLQKAC*QLF*ERWLVMPQLLGTPPTPA LLGHTVGFVALPQRNCGDCPMEQTLRHQHRALG DSVKLTFVSDKISCRLTGQRRPL*AFCRISCPA ICSLFKLK*EHPTHTVCIVFSLDILSIFPCHEFL RNMFLTIVLFSHCPFTIIYLTISLL*NT*DGF* FFHYLNNAVMNIFKIF*FLTFFPLRCLEVVF*G ERVCSF*RYFCLSLDLMCRRSLPVAEPP*LCLTD SEQIGF**AMCSKECLNKTALYLNAKRMSLLQS ICGRFFPRANFLVLVARTWLCLHVSSLPSLLPW LSSAWQNLVLRVHNGTEFASAQSAEITSVELTLP HA**VICN*VYRLRRYIRTFGISSRAKPL*KKP RS*LGFTRVHLSPPSTRGAPPSGLSGSQEPSSQ AGFFIVGRGCPSWCRFQAAPPNSLPTVLQIAWLA ASPDHPNLVGFFISPL*LGSIDCAGERAGGFSR HRVQCCFTLPEIMAKLHGIWFLAL*SLRAPPCL AG*QTRGGHC*DFRDRSCCENTVKVLCSGRCCHT LFPSYFQT*HEPMLTHWVGVPSYAAHVASA*IG AGGTSEPLRGHHFWPKIAGL*MRLPVENWCEEE AVSNKEHFHLLRWLW*ATERAYVCT*IFPVTHFF HMKKHQTMYRELFTKGRPFLSCVTHIA*PPGRM TTNRGHCAGKSLYYDCK*VGCWQN*IVTVFRAA VAVPSQHKIG*MTSTSFRWVASRTCVIFSTWSVA VTVMYRQSKN*KNL*KQMQ*Y*DIHFCIFILI* GYLLAIVGL*FSLCYLNSNI*II*IEFMFGATL LYVLMYSLECE*LL*TIFYNFFSGFII*IFYWVS DLII*FNESVYPFFFSKYLCFRCSYQMMNFPRM VSSLVIKSM*SV

Frame 1

PGAGGGGRRGGRRMRAAIAGAPLRGGGR*GGAE PRSAAGEAPAPTRGPWPGPPASCMTPCPSSPAW CYVPAHPHQW*GPRLSPARPLAFLVAAGRAPPWT ALQPSLGPAPAPCSMPSLRRSLGRSGLRTSSLG KSLGKALFPRLSWLENWQPPENMRLKFWRSDIS *KRTRSPM*PESGMSCRAWITPSLLSFTSHFRTT RSCISALVMPKMENYLNIFAKSVHSMRPVPDFT RLRLCLL*STCTARASFTGTLNRKTFC*MKICT SRSQILEQQKSYPQRANKPGPTHSWEQRSTFLQS CSRRSPPVRVQTFGLLDA*YTSLWQDSHHSELE TSILYFRRSLSWNMTFQKNSSLRQETSWRNFWF *MPQSG*AVRKWKDTDLLKHTRSSSPSRGRTCTS RRLRSSPLTCRLCRKTTRTAMAIMTIS*ASLAA CRCLRPPPHTPCQPPTRACPRGQAAT*SSTFTI WTRTPLNWTYSFPKMRRGCCWRSRLAETLGTSL* KII*Y*RWAQWISGRVYLQDDDSCCSQKDHIYI MWILSTKF*KVKFLGHKNFDQRPRILKLSLSTR LTGRII*WTPAGTHTSGAGRSRRFGGSDTRATRT PLCSDVACGRAALRCQDTCPSAAWPPSGTLPDH LPAITRGTQRRKPCSIFI*KKRRKKTPNHTKNK TSNKHKGIQGRFACSLCSVEASVCPRCRGDPAPC TSTQSRPD*WTDLVSPVFPSISPNHAPALPQLC AGPAVAEGTGCVWLFMPLPLWSWNSSPGREPCG GRSFVEGAAVLLSPAPFLASPCDGPLGLAGPITY PCGGSGGSFLWPLLCWQAGLRGEEREGLEWCGS RLPSGGCHRGLRIPYPT*QCWSLGLEAERMLGA VLSEVSPVSTPLAHCTRESCPEP*VGPGGALEKP ARAERAADFRVEQRGLRAS*KV*MSTPLQLLK* GLREPWHQQTQGASVSCRPRQGVQTPPSHTPLL CFGSSFSEPLRASTSVHQKSHSLLMLPAHLGP*S GLCQLLLHRRREQHTSTPACWSAFL*REPVLGP FPFDALVALPRSAAQTGQMHLSFA*LLPR*RVL LVAWQVWALLSLPRLSLEGSPHSLWGRGRHCCPQ TCL*LNCVHPPWSLPPSHR*LSSDPVCQARSKL RGKVSFLHC**REWLFLARRVQTGPGRGQRCSP GPACGSCLGLGCCCVRAACEPVTVSWGELGRTYP GAPGSRTLRGPARCPGPVAGVGVLSPPPGFWKG LAVLGSLS*PFQEFLFRLPPPHQLFYPSQNVLC LHVGEWLSQISQGVWL*GNKWSRDVALIGALGWA AWGDSSVRSSSG*NHHLLGVTDKLHLNLQSHRT RGSEPELAAASQNDAIA*ADSQALLWVTFLLTQ PLALPF*KARVFSFLTLCLLMSTPVFSTTSLEPS PGTQAPYILR*NVGYCVCT*THLRGITVVGLSK MRKISPAV**TWGHVPPHTWARTGGMSGPHCAA SRHKAEGGCGRCRPRCPRCPAFLWDTVGGWLLRD SFLPSLCGPSQGGGQSWCRAQASPP*RNASVPR LPCGTLTCRRLVNNCFERDGWSCHSCWGLRLLQ PSWDTLWDLWPFPRGIVETVPWNKPSGTSTGLWV TQ*N*RLSLTRSAVGSPAREDHCEHFAVYPALP FVHFLN*NRNIRHTPFASSSPLIF*AFSHVMSF SETCF*QLYYLVIVHLL*FI*PFPYCKILKTVSD FSTI*IML**ISLKSSDFLLFSPLDAWKWYFEV KEFVHFEDISVSLST*CVDAHFQ*QNHLSCVLQ ILNKSVSDKPCVPKNV*IRPLFI*MLRGCHYCNP SVADFFQEPISLFWLQEPGSACMSALCPPCCRG FQALGRILYFVSTMVLNLHLHSQQR*QVLN*PC HMLSE*FVIKFIDSEGILGHLESVAEQSLFEKNH VADWVLQECICLPLPPVGPHLQVLVVHKSPAAR LAFSL*GVVVPAGVDFRPPPPTPCPQCCRLPGW QQVQTTQIWLDSSFLHCSWGPLIVQGNVQEVFLG TVFSAASLYQRLWPNCTEFGFLPSEA*GPPLAW LVDRPGVVTAETSEIAAAVRIR*RYFVLEDVVI HFSPVIFKLDMSLC*LTGWGSLLTQHTWQVPESG LEALQSL*GATTSGPKLQGCR*GCLWRTGVRRK LFPTKSTFIC*DGCGEQLNEPTCVPEFSP*LIS SI*RNTKLCTENFLQKADLF*AV*PT*PNHLAE* LRIGVIVLVKASITTVSKLDVGKIKLLQYLELL *LFLHNIK*DK*LVRLSGGWQAEHA*YSLPGL* L*L*CTDKAKIKRTYENKCNDTRIYTFVFLFLYK VICWLLLASSSVCVI*ILIYELFELNSCSGPRC CMY*CTALNVNNYCKLYFTTFFLALLYKFSIGS VI*SYNLMNLFILFFFPNTCALGVVTR**IFLVW SVVL**KACRV

Frame 2

RGRGAAGDGAGAG*GRPLLGLRFGEEDAEEAPS RAALRGRRPRRRGAHGQDHQPAV*RRAHPVQRG VMFLPIPINGEDPD*VQHAPWHSWWQQAGPRHG RHCSRASARRRLPAACPASAAASEEAA*GLQVWE NPWGRLFFHGCPGSRTGNLQRICD*NSGEATYH KREQGPLCNQRAGCHVAPGSPLLC*ALLHISGR REAVFRP*LCQKWRTT*IYSQNRFIR*DLYPILH G*DCVCFRVLARQGHHSQGP*TGKHFVK*RYAH PDHRFWNSKSLIPREQTSQGQLIRGNSAVRFSR AAHGEVRL*EFRPLGSWMHNIPACGRTPTIPSWK RVSYISEDH*VGI*LSRKILP*GKRPRGETFGF RCHKAVRL*GNGRIRTS*STPVLRVRHVGEPAP ADASEAHRLPAGYVGRRRGLLWQL*QSPEPVWLH AGVFVLLLTLPVSLRHGPAPEVRQQHRAVHSRS GLELL*TGLTVFRR*EEVVVGEAGWRKPLAPVC RK*FNTKDGPSG*AEGFICKTTTAVAHRRTTFIL CGSCQQSSER*NSLVTRTSTRGQEF*NFLCPHA *QDVLSDGPQRERTQVVQEDPGGLEAAIPEPPG RRCAVTWPAAGLPFAARTPAPARLGRHPGRFQTT CQPSQGERRGGNLAAFLFKRKEEKKHPTTQRTK PVTNTKEFRVALLALCAPWRPPCALVAVGTQLH ARQPSPAQTSGQTWCHQFFLASVRTMRPPCPNCV LVLLWPRGPGVFGSLCPSRCGPGTLHQGGSPAG AAALWREPPCFCHLLPFLRLPVMGP*AWLGPLH IPVVALVAAFCGPCCVGRQVCVVRSGRGWSGAGA GCRVEGAIEGSGSLILLSSVGLWGWKPSACWER YCQK*AQLVPRWLTARESPAPSPRWGQEVPWRS QPEQRGLLTSVWSREA*GPPKRFKCPRLSSC*SR V*ENPGISRPRVLLSPADHARECRHHRHTRPFC VLVQVSQSPSELLHLCIRNLTAFSCCRLIWAHR VGFASCCCTGGENSTLQPQLAGRLSSRESRFWGH FPLMLWWPCPALQHRQARCICPLPSYSPGRECS WWPGRSGPFSPCPGCPWRAALTPFGGEADIAAH RPASDSTVSTLPGPYPQVTGDSAVTLCARPDPN* EGRCRFYTANDESGSF*LGEYRRGLGGGRDVPQ ALPVVPAWALAAAV*ELHVSL*P*AGVSWAAPT LGPQGAGRSGAQHVALGLWPESESSLLLLAFGKA WLCWGVSLSPFRNFCSGFLLLISYFTHLRTSCV SM*ESGSLRSLRASGYRETSGAGTWL*LEHSAG LLGETLPCVLPLDRTTTSWASLTSSILTSKATEL GAQSQSWQPPAKMMPLPELTAKPFCGSPFSSPS PLLFPFERPVCFLSLPCACSCLLRFSLPHP*SH HLARRRLTFYGRTWGTVCAHRHTYVELQLWVYPR *GRFHLLFNRLGAMCLPTHGQGQVECRDHTVRL LGTKRREAVVAAGLGVPGAPPFSGTQLGAGF*G IPFSPLCVAPARAVGSPGVEHKPLHPREMPLYHG YHVEP*LAEGLLTIVLREMAGHATAAGDSAYSS PLGTHCGICGPSPEELWRLSHGTNPQAPAQGSG *LSKTNVCL*QDQL*AHRPEKTTVSILPYILPCH LFTF*TKIGTSDTHRLHRLLP*YFKHFPMS*VS QKHVFNNCTI*SLSIYYNLSDHFPTVKYLRRFL IFPLFK*CCDEYL*NLLISYFFPP*MPGSGILR* KSLFILKIFLSLSRPDV*TLTSSSRTTLVVSYR F*TNRFLISHVFQRMSE*DRSLFKC*EDVTTAI HLWPIFSKSQFPCFGCKNLALPACQLSALPAAVA FKRLAESCTSCPQWY*ICICTVSRDNKC*TDLA TCLVSDL*LSL*TQKVY*DIWNQ*QSKASLKKT T*LIGFYKSAFVSPFHPWGPTFRS*WFTRAQQPG WLFHCRAWLSQLV*ISGRPPQLPAHSVADCLAG SKSRPPKFGWILHFSTVVGVH*LCRGTCRRFF* APCSVLLHSTRDYGQIARNLVSCPLKPEGPPLPG WLTDPGWSLLRLQRSQLL*EYGEGTLFWKMLSY TFPQLFSNLT*AYVDSLGGGPFLRSTRGKCLNR GWRHFRASEGPPLLAQNCRVVDEAACGELV*GGS CFQQRALSSVEMAVVSN*TSLRVYLNFPRNSFL PYEETPNYVQRTFYKRQTFFKLCNPHSLTTWQN DYE*GSLCW*KPLLRL*VSWMLAKLNCYSI*SCC SCSFTT*NRIND*YVFQVGGKQNMRNILYLVCS CNCDVQTKQKLKELMKTNAMILGYTLLYFYSYI RLFAGYCWPLVQSVLFKF*YMNYLN*IHVRGHVV VCIDVQP*M*IIIVNYILQLFFWLYYINFLLGQ *FNHII**ICLSFFFFQILVL*V*LPDDEFSSY GQ*SCNKKHVEC