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Sequences

Sequence BCL2L11.jAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG CCCCTACCTCCCTACAGACAGAGCCACAAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAA CCACTATCTCAGTGCAATGGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAG TTTAACGCTTACTATGCAAGGAGGTTAGAGAAATAGAGGAAGTTGTCGTGTAGTTGTCATGTATTCAGTCCACTTAAGGGCAGTGGGGAAGCGTTTGAGA CGGAGCTGTGGAGGCTGAATCCTTGAAGGAGGAGGTGAGAGAGGCACAGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATC TTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACC AACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGAT GGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACC ATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACT TTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCT AACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGA CCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCC ATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTC CAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGT TCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTA ATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAG AGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATT TGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATA GAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTC TTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTC AGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAA ATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCT AAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTT TAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTG GTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCA CCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGC AGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGC TGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCT CTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAA AAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACA GAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGG AGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAG ATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAA TCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTA GAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACT CCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGG TTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATAC CCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTAT TATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTG CAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACT GTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCA CGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCAC TGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGT GCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAG AAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCA CTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTA TGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAAT AACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT

113317 (forward primer)
BCL2L11-4 (reverse primer)
Intron retention

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG APTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFN HYLSAMASMRQAEPADMRPEIWIAQELRRIGDE FNAYYARRLEK*RKLSCSCHVFSPLKGSGEAFE TELWRLNP*RRR*ERHRYF*IITKQPKTTHEWLS YDCYVTLSAWCGECIDRFFAEPRYHADILLVQT NKTQHRGLLVPLLCSQRFSCGGGR*RFRRHRAG WDYLSVHHHTAEFLMEVCCECKGGSILCFLIYKP WFFGAGFCVRMVFTCSVFSPSPSIRFFKKEMET F*PICE*LLY*NFKNLRPILRGLCNPCSGN*AS *LKKLP*FIFRDYRIFKQGDV*YTPSLPYYCLSD LFKLFLIPKEFF*NGTD*KGRGSVASLH*YTSP ICKYLRTFINSVASVAKFQTIFASFLITFCDAT PVWTQMHRFGPVYFHDKVKLSQNKS*YLPVSCTV RAICY*LGSIWCWFSFHFDEHVIGKYSEEAIAV ITTDLSATPLCAAGFSGCRLSHGHRMHCQHQVP EGHRVHYSRVQLQHPAHALMGIGTGLGQGF*WPF AWPPAF*SNSQSTSFTPLNSL*NRPHPTSTSTI EE*FWAEVCFFSFFQDSWILSGHL*PQPCSEGA LSLCLLLMSAVEGSHTLVSHFRGSRCPGRPKKES G*GAVKVRREDNSVNSVTLKIFENSIVKQLLKE ITKFSNE*AVPPTSVLPDRRASMFTLFKLGGKI *TFLSS*FKKYICIYCIFTFSFR*R*FQSKYSYF KKFPFPKNLLGTLTYF*SCVGAHLVP*CVSSPL VGSYKAHGYKQW*DCSRGPAGHTHTPKMYLDLG TPSQDPCTHVPVS*LEHFTLFPQPCSPWEHTLGA ALGQAREALPCAAQGLCAPHEHISLWPGGLQAG CGNSS*GN*RFYEL*EY*RPGCWHQNLKR*LDV SVLYVSGYQDASVQKVCLPWVYVFTFFKKHFCRK NN*IPFLETYCRFCALTTSPYVRFVKSVL*LNT ETQ*THTK*FHE*FFRCPSQLVS*SRILGVGVA EKSSLKFLLIKKI*WNTIVCRFPFLMYIL*VFIR FVGHITYQLSQMSVCNCVSFTL*NFVQHK*VKK SLFFSTFSKSRIVNIVDSFSV*CVLLFHNAVTC RNIVYLFSAYLMS*FLKSINIPVSHSPAVP*S*L LRVVGGDWRAHCRPRGPPGWLSTFGSWYFQSSG FQFLGFAALMMKCVFDASEKLSLAGYKILLQEI PSNLLFVPKQLAYHASKFC*LQALSLGKQKNQSI ISRWERFFY*KFIPDNSAFRKEIKCATSRGAAL QLFRARARQDK*MGGTGGSCLRTTSGH*PLVDN CE*LGFPPPAVQLPVL*GWTNLSSGAN*LYSPPH APPIRSLHLVSLLLQVDALLLILHLLQGRLGPH WTGCQDVKAYGSFKETSWWFHAGGSAIPADLAW CLCVSTHVHVGWGKRVYR*R*ISWGLL*TALCVR SILKLPVK*LDYFYLGISDYRSSLMFYVQIL*P LVTVSELIRYPLINSTDLAVY*SITNLFSRTQR M*HLYCSFPGLLVFCTDEF*QGNCHFTCAILL*I TADF*TIFYVNFIKIKLSTSF

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG PLPPYRQSHKTGAQHP*VVTNQHKPQVLLARPS TTISVQWLP*GRLNLQICAQRYGSPKSCGVLETS LTLTMQGG*RNRGSCRVVVMYSVHLRAVGKRLR RSCGG*ILEGGGERGTGIFE*LPSSRRPPTNGY LTTVTLHCPPGVENALTGSLRSRDTMQTFCLFKP TRPSTAVSWCHYYAASGSLVEGAGDVSEDTELD GTTFLFITTQQNF*WKFVVNVKEGAFFAF*YTN HGFLEQDFV*EWCLHAVCFPPHLQ*GFSKRKWKL FNQFVNNFCIKILRTYGLFSEDYVTPAVETEPA NLKSCLSLFLEITEFLNRETCDILPPFPTIASL TFLNYF*YQKSSFEMELIKRAEGLLPACIDIPVP FVNIYVPL*IQLHLWQNFRLFLRLSSSLFVMQL QSGLRCIDLVQCIFMIK*N*VRTRVNICLYLAQ FERSVINWEAFGVGFHSISTSMLLGSILKRQ*Q* *QQT*VLRPFVLLAFLVAGFPMVTGCTVSIRSQ RATVSITAESSCSIQLTPSWELAQAWGRASDGH LLGLLHFSPTHSPLASLL*IHFETGLIPLPPAP* KNNSGQKSVFFHFSRTVGYCQATCDPSHVVRVL FLCACSL*VQWKEATHWSVISEAADAQGDPRKS QVREQ*K*GGKTIL*TL*LLKFLKTPSLNNF*KK *LNFQMSKQCHQLVFCPIEEPACSRYLN*VEKS KHFYLHNLKNIYVYIAYSLFPLGRDDFNPNTLT LKNFLSPRISLGL*LIFKAVLELILFPDVSRAHW *GHTKPTVTSSGRIAAVGLLDTHIHQRCIWIWA PPPRIPVLTCQSPD*STLLCFLSPAAPGSTHWV QPWARHGRPCPVLPRGCVHHMSTFPSGLAASRLA VETVPEEIRDSMNCRSIKDQAVGTRT*SDDWMS LYCMYLVIKMPLCRKYASRGYTFLPFLKNIFVE KIIKSPFWKLTAGFVP*QPLPM*GL*KVSCDLTQ KRNKHTQNSFMSDSSDALPNWLVDQEFWGWGLR RNQV*NSF*LKKYSGIQLSAVSPS*CIYCEYLL DS*VILLIN*AKCLCAIVFPLPCKILYSINK*KN HCFSQLFQNQGL*IL*ILFLCDVSYCFIML*LV EILYIYFLLI*CLNF*KVLTSLSPTPLPSHEVN S*ELSGVTGELIADHVVLQGGSPPSGPGISSQVG FNSWALPPL**SVCLMPVRNSVWQATKFYSKKY PATFCLFQSN*LIMQANFADSRLYL*ENKKTKV LSAGGKDFSIENLSLTTQRLEKK*NVPLPEVLHC SCSGLGPGRTSEWVGQVAPA*GPPQATNPLWTT VSSWVFPHLLCNFLCFEVGLTCLQELINCTALP TPHPYGHCIWSACFFRSMPSF*YSISFRGGWGPT GLGVKM*KLMGALRRLHGGSMQVVLPSLLI*PG ACVCPLTYTWGGGNVSTDDAKSVGVYSKQHCV* EASSSSQLSNLTTFIWEFQTIEALLCFMSRFCDH *LLYQNSSGTHL*IALIWLYTDPSLTCFLGPSV CSICIAVSLAYLCFALMNFDRVIATLLVQYCCK *LQIFKQSFMLIL*K*NFQLV

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG PYLPTDRATRQEPSTHEL*QINTNPKSSLPGLQ PLSQCNGFHEAG*TCRYAPRDMDRPRVAAYWRR V*RLLCKEVREIEEVVV*LSCIQST*GQWGSV*D GAVEAESLKEEVREAQVFLNNYQAAEDHPRMVI LRLLRYIVRLVWRMH*QVLCGAEIPCRHFACSN QQDPAPRSPGAIIMQPAVLLWRGQVTFQKTPSWM GLPFCSSPHSRISNGSLL*M*RREHSLLFNIQT MVFWSRILCKNGVYMQCVFPLTFNKVFQKGNGN FLTNL*ITFVLKF*EPTAYSQRIM*PLQWKLSQL T*KAALVYF*RLQNF*TGRRVIYSLPSLLLPL* PF*IIFNTKRVLLKWN*LKGQRVCCQPALIYQS HL*IFTYLYKFSCICGKISDYFCVFPHHFL*CNS SLDSDA*IWSSVFS**SEIESEQELISACILHS SSDLLLTGKHLVLVFIPFRRACYWEVF*RGNSS NNNRLKCYAPLCCWLFWLQAFPWSQDALSASGPR GPPCPLQQSPAAASSSRPHGNWHRPGAGLLMAI CLASCILVQLTVH*LHSFKFTLKQASSHFHQHH RRIILGRSLFFFIFPGQLDIVRPLVTPAM**GCS FSVPAPYECSGRKPHTGQSFQRQQMPRETQERV RLGSSESEEGRQFCELCNS*NF*KLHR*TTFKR NN*IFK*VSSATN*CFAR*KSQHVHVI*IRWKNL NIFIFII*KIYMYILHIHFFL*VEMISIQILLL *KISFPQESPWDFDLFLKLCWSSSCSLMCLEPI GRVIQSPRLQAVVGLQPWACWTHTYTKDVFGSGH PLPGSLYSRASLLTRALYSVSSALQPLGAHTGC SPGPGTGGPALCCPGAVCTT*AHFPLAWRPPGW LWKQFLRKLEIL*IVGVLKTRLLAPELKAMTGCL CTVCIWLSRCLCAESMPPVGIRFYLF*KTFL*K K*LNPLFGNLLQVLCLDNLSLCEVCKKCPVT*H RNAINTHKIVS*VILQMPFPTG*LIKNFGGGGCG EIKFKIPSD*KNIVEYNCLPFPLLNVYIVSIY* IRRSYYLSTEPNVCVQLCFLYLVKFCTA*ISKK ITVFLNFFKIKDCKYCRFFFCVMCPTVS*CCNL* KYCIFIFCLFNVLISEKY*HPCLPLPCRPMKLT PESCRG*LESSLQTTWSSRVALHLRVLVFPVKW VSILGLCRPYDEVCV*CQ*ETQSGRLQNSTPRNT QQPSVCSKATSLSCKQILLTPGFIFRKTKKPKY YQQVGKIFLLKIYP*QLSV*KRNKMCHFQRCCI AVVQG*GQAGQVNGWDRWLLPKDHLRPLTPCGQL *VAGFSPTCCATSCALRLD*LVFRS*LTVQPSP RPTHTVTAFGQPASSGRCPPSDTPSPSGEVGAP LDWVSRCESLWEL*GDFMVVPCRWFCHPC*FSLV PVCVHSRTRGVGETCLQMTLNQLGSTLNSIVCK KHPQAPS*VT*LLLFGNFRL*KLSYVLCPDSVT TSYCIRTHQVPTYK*H*SGCILIHH*PVF*DPAY VAFVLQFPWLTCVLH**ILTG*LPLYLCNTAVN NCRFLNNLLC*FYKNKTFN*F

Sequence BCL2L11.dAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG CCCCTACCTCCCTACAGACAGAGCCACAAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAA CCACTATCTCAGTGCAATGGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAG TTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTACGTTACATTGTCC GCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGGTCTCC TGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTCATCACCA CACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGGATTTTGT GTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATAACTTT TGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAGTTTAT TTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTTAATACCA AAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATTTACGTACCTTTA TAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCATAGATT TGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAACTGGGA AGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGTGCTACGC CCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATTACAGCAG AGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTTAGTCC AACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGAAGTCT GTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCCTTATGAG TGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAGTGAGG AGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGAGTAAG CAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAATTTAA AAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCCCAAGAAT CTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCCCACGGTT ACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGTACTCA CGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGGAGGCC CTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGAGGAAATT AGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTGGTTATCA AGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTTTGGAA ACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAACACACACAAAAT AGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAATTCCTTCT GATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCATATTACTTATCAA CTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTTTTCAA AATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTTTCTGC TTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGGTGACTGG AGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTTGCCGCCC TTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTTCCAAA GCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGATTTTTC TATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGGGCCAGGC AGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTCCCCCACC TGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCACTGCAT TTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGTGAAAG CTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTCACGTACA CGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCCAGTTAAG TAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACTCATCA GGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGTTTCCC TGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAACAATCTTT TATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT

113317 (forward primer)
BCL2L11-4 (reverse primer)
Intron retention

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG APTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFN HYLSAMASMRQAEPADMRPEIWIAQELRRIGDE FNAYYARRVFLNNYQAAEDHPRMVILRLLRYIV RLVWRMH*QVLCGAEIPCRHFACSNQQDPAPRSP GAIIMQPAVLLWRGQVTFQKTPSWMGLPFCSSP HSRISNGSLL*M*RREHSLLFNIQTMVFWSRIL CKNGVYMQCVFPLTFNKVFQKGNGNFLTNL*ITF VLKF*EPTAYSQRIM*PLQWKLSQLT*KAALVY F*RLQNF*TGRRVIYSLPSLLLPL*PF*IIFNT KRVLLKWN*LKGQRVCCQPALIYQSHL*IFTYLY KFSCICGKISDYFCVFPHHFL*CNSSLDSDA*I WSSVFS**SEIESEQELISACILHSSSDLLLTG KHLVLVFIPFRRACYWEVF*RGNSSNNNRLKCYA PLCCWLFWLQAFPWSQDALSASGPRGPPCPLQQ SPAAASSSRPHGNWHRPGAGLLMAICLASCILV QLTVH*LHSFKFTLKQASSHFHQHHRRIILGRSL FFFIFPGQLDIVRPLVTPAM**GCSFSVPAPYE CSGRKPHTGQSFQRQQMPRETQERVRLGSSESE EGRQFCELCNS*NF*KLHR*TTFKRNN*IFK*VS SATN*CFAR*KSQHVHVI*IRWKNLNIFIFII* KIYMYILHIHFFL*VEMISIQILLL*KISFPQE SPWDFDLFLKLCWSSSCSLMCLEPIGRVIQSPRL QAVVGLQPWACWTHTYTKDVFGSGHPLPGSLYS RASLLTRALYSVSSALQPLGAHTGCSPGPGTGG PALCCPGAVCTT*AHFPLAWRPPGWLWKQFLRKL EIL*IVGVLKTRLLAPELKAMTGCLCTVCIWLS RCLCAESMPPVGIRFYLF*KTFL*KK*LNPLFG NLLQVLCLDNLSLCEVCKKCPVT*HRNAINTHKI VS*VILQMPFPTG*LIKNFGGGGCGEIKFKIPS D*KNIVEYNCLPFPLLNVYIVSIY*IRRSYYLS TEPNVCVQLCFLYLVKFCTA*ISKKITVFLNFFK IKDCKYCRFFFCVMCPTVS*CCNL*KYCIFIFC LFNVLISEKY*HPCLPLPCRPMKLTPESCRG*L ESSLQTTWSSRVALHLRVLVFPVKWVSILGLCRP YDEVCV*CQ*ETQSGRLQNSTPRNTQQPSVCSK ATSLSCKQILLTPGFIFRKTKKPKYYQQVGKIF LLKIYP*QLSV*KRNKMCHFQRCCIAVVQG*GQA GQVNGWDRWLLPKDHLRPLTPCGQL*VAGFSPT CCATSCALRLD*LVFRS*LTVQPSPRPTHTVTA FGQPASSGRCPPSDTPSPSGEVGAPLDWVSRCES LWEL*GDFMVVPCRWFCHPC*FSLVPVCVHSRT RGVGETCLQMTLNQLGSTLNSIVCKKHPQAPS* VT*LLLFGNFRL*KLSYVLCPDSVTTSYCIRTHQ VPTYK*H*SGCILIHH*PVF*DPAYVAFVLQFP WLTCVLH**ILTG*LPLYLCNTAVNNCRFLNNL LC*FYKNKTFN*F

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG PLPPYRQSHKTGAQHP*VVTNQHKPQVLLARPS TTISVQWLP*GRLNLQICAQRYGSPKSCGVLETS LTLTMQGGYF*IITKQPKTTHEWLSYDCYVTLS AWCGECIDRFFAEPRYHADILLVQTNKTQHRGL LVPLLCSQRFSCGGGR*RFRRHRAGWDYLSVHHH TAEFLMEVCCECKGGSILCFLIYKPWFFGAGFC VRMVFTCSVFSPSPSIRFFKKEMETF*PICE*L LY*NFKNLRPILRGLCNPCSGN*AS*LKKLP*FI FRDYRIFKQGDV*YTPSLPYYCLSDLFKLFLIP KEFF*NGTD*KGRGSVASLH*YTSPICKYLRTF INSVASVAKFQTIFASFLITFCDATPVWTQMHRF GPVYFHDKVKLSQNKS*YLPVSCTVRAICY*LG SIWCWFSFHFDEHVIGKYSEEAIAVITTDLSAT PLCAAGFSGCRLSHGHRMHCQHQVPEGHRVHYSR VQLQHPAHALMGIGTGLGQGF*WPFAWPPAF*S NSQSTSFTPLNSL*NRPHPTSTSTIEE*FWAEV CFFSFFQDSWILSGHL*PQPCSEGALSLCLLLMS AVEGSHTLVSHFRGSRCPGRPKKESG*GAVKVR REDNSVNSVTLKIFENSIVKQLLKEITKFSNE* AVPPTSVLPDRRASMFTLFKLGGKI*TFLSS*FK KYICIYCIFTFSFR*R*FQSKYSYFKKFPFPKN LLGTLTYF*SCVGAHLVP*CVSSPLVGSYKAHG YKQW*DCSRGPAGHTHTPKMYLDLGTPSQDPCTH VPVS*LEHFTLFPQPCSPWEHTLGAALGQAREA LPCAAQGLCAPHEHISLWPGGLQAGCGNSS*GN *RFYEL*EY*RPGCWHQNLKR*LDVSVLYVSGYQ DASVQKVCLPWVYVFTFFKKHFCRKNN*IPFLE TYCRFCALTTSPYVRFVKSVL*LNTETQ*THTK *FHE*FFRCPSQLVS*SRILGVGVAEKSSLKFLL IKKI*WNTIVCRFPFLMYIL*VFIRFVGHITYQ LSQMSVCNCVSFTL*NFVQHK*VKKSLFFSTFS KSRIVNIVDSFSV*CVLLFHNAVTCRNIVYLFSA YLMS*FLKSINIPVSHSPAVP*S*LLRVVGGDW RAHCRPRGPPGWLSTFGSWYFQSSGFQFLGFAA LMMKCVFDASEKLSLAGYKILLQEIPSNLLFVPK QLAYHASKFC*LQALSLGKQKNQSIISRWERFF Y*KFIPDNSAFRKEIKCATSRGAALQLFRARAR QDK*MGGTGGSCLRTTSGH*PLVDNCE*LGFPPP AVQLPVL*GWTNLSSGAN*LYSPPHAPPIRSLH LVSLLLQVDALLLILHLLQGRLGPHWTGCQDVK AYGSFKETSWWFHAGGSAIPADLAWCLCVSTHVH VGWGKRVYR*R*ISWGLL*TALCVRSILKLPVK *LDYFYLGISDYRSSLMFYVQIL*PLVTVSELI RYPLINSTDLAVY*SITNLFSRTQRM*HLYCSFP GLLVFCTDEF*QGNCHFTCAILL*ITADF*TIF YVNFIKIKLSTSF

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG PYLPTDRATRQEPSTHEL*QINTNPKSSLPGLQ PLSQCNGFHEAG*TCRYAPRDMDRPRVAAYWRR V*RLLCKEGIFE*LPSSRRPPTNGYLTTVTLHCP PGVENALTGSLRSRDTMQTFCLFKPTRPSTAVS WCHYYAASGSLVEGAGDVSEDTELDGTTFLFIT TQQNF*WKFVVNVKEGAFFAF*YTNHGFLEQDFV *EWCLHAVCFPPHLQ*GFSKRKWKLFNQFVNNF CIKILRTYGLFSEDYVTPAVETEPANLKSCLSL FLEITEFLNRETCDILPPFPTIASLTFLNYF*YQ KSSFEMELIKRAEGLLPACIDIPVPFVNIYVPL *IQLHLWQNFRLFLRLSSSLFVMQLQSGLRCID LVQCIFMIK*N*VRTRVNICLYLAQFERSVINWE AFGVGFHSISTSMLLGSILKRQ*Q**QQT*VLR PFVLLAFLVAGFPMVTGCTVSIRSQRATVSITA ESSCSIQLTPSWELAQAWGRASDGHLLGLLHFSP THSPLASLL*IHFETGLIPLPPAP*KNNSGQKS VFFHFSRTVGYCQATCDPSHVVRVLFLCACSL* VQWKEATHWSVISEAADAQGDPRKSQVREQ*K*G GKTIL*TL*LLKFLKTPSLNNF*KK*LNFQMSK QCHQLVFCPIEEPACSRYLN*VEKSKHFYLHNL KNIYVYIAYSLFPLGRDDFNPNTLTLKNFLSPRI SLGL*LIFKAVLELILFPDVSRAHW*GHTKPTV TSSGRIAAVGLLDTHIHQRCIWIWAPPPRIPVL TCQSPD*STLLCFLSPAAPGSTHWVQPWARHGRP CPVLPRGCVHHMSTFPSGLAASRLAVETVPEEI RDSMNCRSIKDQAVGTRT*SDDWMSLYCMYLVI KMPLCRKYASRGYTFLPFLKNIFVEKIIKSPFWK LTAGFVP*QPLPM*GL*KVSCDLTQKRNKHTQN SFMSDSSDALPNWLVDQEFWGWGLRRNQV*NSF *LKKYSGIQLSAVSPS*CIYCEYLLDS*VILLIN *AKCLCAIVFPLPCKILYSINK*KNHCFSQLFQ NQGL*IL*ILFLCDVSYCFIML*LVEILYIYFL LI*CLNF*KVLTSLSPTPLPSHEVNS*ELSGVTG ELIADHVVLQGGSPPSGPGISSQVGFNSWALPP L**SVCLMPVRNSVWQATKFYSKKYPATFCLFQ SN*LIMQANFADSRLYL*ENKKTKVLSAGGKDFS IENLSLTTQRLEKK*NVPLPEVLHCSCSGLGPG RTSEWVGQVAPA*GPPQATNPLWTTVSSWVFPH LLCNFLCFEVGLTCLQELINCTALPTPHPYGHCI WSACFFRSMPSF*YSISFRGGWGPTGLGVKM*K LMGALRRLHGGSMQVVLPSLLI*PGACVCPLTY TWGGGNVSTDDAKSVGVYSKQHCV*EASSSSQLS NLTTFIWEFQTIEALLCFMSRFCDH*LLYQNSS GTHL*IALIWLYTDPSLTCFLGPSVCSICIAVS LAYLCFALMNFDRVIATLLVQYCCK*LQIFKQSF MLIL*K*NFQLV

Sequence BCL2L11.qAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG CCCCTACCTCCCTACAGACAGAGCCACAAGGTAATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGC CCCACCTGCCAGCCCTGGCCCTTTTGCTACCAGATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCT TTTGACACAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGG CTAACTGGGACTAGAAACAGCTCCATCACCCAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCG TATTGGAGACGAGTTTAACGCTTACTATGCAAGGAGGATGCCTCTTCCACCTGATTAAGAACCACTGTAGCAGACGCAGACTTATTGGACACTAGGCGGG AGGCCAGCTCTGCAGACAGCAGGTCTCAGGAAGACGGTCAAGGCATGGCTGCTGATGATCCGCTTATGGGTATTTTTGAATAATTACCAAGCAGCCGAAG ACCACCCACGAATGGTTATCTTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAG ACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTT CAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTT TGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTT TCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTG CAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTT CCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCC TGCATTGATATACCAGTCCCATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCAT CACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATAT CTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATT CTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCA CTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGG CAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATC CCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCA GCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCA GGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCG TTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATT TAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTT CAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCT GATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAA GATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCC TGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGC CTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTT AAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTT AAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAA GTGTCCTGTGACTTAACACAGAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAAT TTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTAT ATATTGTGAGTATTTATTAGATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTAC AGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTT TCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCT GCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCT GGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAA AATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGA AAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCA CTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCA CTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAAT TAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTC AGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCAT CCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTC TAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTT ATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCT GTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACT TGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT

113317 (forward primer)
BCL2L11-4 (reverse primer)
Intron retention

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG APTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLA PPASPGPFATRSPLFIFMRRSSLLSRSSSGYFS FDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM ANWD*KQLHHPASMRQAEPADMRPEIWIAQELRR IGDEFNAYYARRMPLPPD*EPL*QTQTYWTLGG RPALQTAGLRKTVKAWLLMIRLWVFLNNYQAAE DHPRMVILRLLRYIVRLVWRMH*QVLCGAEIPCR HFACSNQQDPAPRSPGAIIMQPAVLLWRGQVTF QKTPSWMGLPFCSSPHSRISNGSLL*M*RREHS LLFNIQTMVFWSRILCKNGVYMQCVFPLTFNKVF QKGNGNFLTNL*ITFVLKF*EPTAYSQRIM*PL QWKLSQLT*KAALVYF*RLQNF*TGRRVIYSLP SLLLPL*PF*IIFNTKRVLLKWN*LKGQRVCCQP ALIYQSHL*IFTYLYKFSCICGKISDYFCVFPH HFL*CNSSLDSDA*IWSSVFS**SEIESEQELI SACILHSSSDLLLTGKHLVLVFIPFRRACYWEVF *RGNSSNNNRLKCYAPLCCWLFWLQAFPWSQDA LSASGPRGPPCPLQQSPAAASSSRPHGNWHRPG AGLLMAICLASCILVQLTVH*LHSFKFTLKQASS HFHQHHRRIILGRSLFFFIFPGQLDIVRPLVTP AM**GCSFSVPAPYECSGRKPHTGQSFQRQQMP RETQERVRLGSSESEEGRQFCELCNS*NF*KLHR *TTFKRNN*IFK*VSSATN*CFAR*KSQHVHVI *IRWKNLNIFIFII*KIYMYILHIHFFL*VEMI SIQILLL*KISFPQESPWDFDLFLKLCWSSSCSL MCLEPIGRVIQSPRLQAVVGLQPWACWTHTYTK DVFGSGHPLPGSLYSRASLLTRALYSVSSALQP LGAHTGCSPGPGTGGPALCCPGAVCTT*AHFPLA WRPPGWLWKQFLRKLEIL*IVGVLKTRLLAPEL KAMTGCLCTVCIWLSRCLCAESMPPVGIRFYLF *KTFL*KK*LNPLFGNLLQVLCLDNLSLCEVCKK CPVT*HRNAINTHKIVS*VILQMPFPTG*LIKN FGGGGCGEIKFKIPSD*KNIVEYNCLPFPLLNV YIVSIY*IRRSYYLSTEPNVCVQLCFLYLVKFCT A*ISKKITVFLNFFKIKDCKYCRFFFCVMCPTV S*CCNL*KYCIFIFCLFNVLISEKY*HPCLPLP CRPMKLTPESCRG*LESSLQTTWSSRVALHLRVL VFPVKWVSILGLCRPYDEVCV*CQ*ETQSGRLQ NSTPRNTQQPSVCSKATSLSCKQILLTPGFIFR KTKKPKYYQQVGKIFLLKIYP*QLSV*KRNKMCH FQRCCIAVVQG*GQAGQVNGWDRWLLPKDHLRP LTPCGQL*VAGFSPTCCATSCALRLD*LVFRS* LTVQPSPRPTHTVTAFGQPASSGRCPPSDTPSPS GEVGAPLDWVSRCESLWEL*GDFMVVPCRWFCH PC*FSLVPVCVHSRTRGVGETCLQMTLNQLGST LNSIVCKKHPQAPS*VT*LLLFGNFRL*KLSYVL CPDSVTTSYCIRTHQVPTYK*H*SGCILIHH*P VF*DPAYVAFVLQFPWLTCVLH**ILTG*LPLY LCNTAVNNCRFLNNLLC*FYKNKTFN*F

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG PLPPYRQSHKVILKAITEVKGTAAPTAALRARW PHLPALALLLPDPRFSSL*EDPPCCLDPPVGISL LTQTGAQHP*VVTNQHKPQVLLARPSTTISVQW LTGTRNSSITQLP*GRLNLQICAQRYGSPKSCG VLETSLTLTMQGGCLFHLIKNHCSRRRLIGH*AG GQLCRQQVSGRRSRHGC**SAYGYF*IITKQPK TTHEWLSYDCYVTLSAWCGECIDRFFAEPRYHA DILLVQTNKTQHRGLLVPLLCSQRFSCGGGR*RF RRHRAGWDYLSVHHHTAEFLMEVCCECKGGSIL CFLIYKPWFFGAGFCVRMVFTCSVFSPSPSIRF FKKEMETF*PICE*LLY*NFKNLRPILRGLCNPC SGN*AS*LKKLP*FIFRDYRIFKQGDV*YTPSL PYYCLSDLFKLFLIPKEFF*NGTD*KGRGSVAS LH*YTSPICKYLRTFINSVASVAKFQTIFASFLI TFCDATPVWTQMHRFGPVYFHDKVKLSQNKS*Y LPVSCTVRAICY*LGSIWCWFSFHFDEHVIGKY SEEAIAVITTDLSATPLCAAGFSGCRLSHGHRMH CQHQVPEGHRVHYSRVQLQHPAHALMGIGTGLG QGF*WPFAWPPAF*SNSQSTSFTPLNSL*NRPH PTSTSTIEE*FWAEVCFFSFFQDSWILSGHL*PQ PCSEGALSLCLLLMSAVEGSHTLVSHFRGSRCP GRPKKESG*GAVKVRREDNSVNSVTLKIFENSI VKQLLKEITKFSNE*AVPPTSVLPDRRASMFTLF KLGGKI*TFLSS*FKKYICIYCIFTFSFR*R*F QSKYSYFKKFPFPKNLLGTLTYF*SCVGAHLVP *CVSSPLVGSYKAHGYKQW*DCSRGPAGHTHTPK MYLDLGTPSQDPCTHVPVS*LEHFTLFPQPCSP WEHTLGAALGQAREALPCAAQGLCAPHEHISLW PGGLQAGCGNSS*GN*RFYEL*EY*RPGCWHQNL KR*LDVSVLYVSGYQDASVQKVCLPWVYVFTFF KKHFCRKNN*IPFLETYCRFCALTTSPYVRFVK SVL*LNTETQ*THTK*FHE*FFRCPSQLVS*SRI LGVGVAEKSSLKFLLIKKI*WNTIVCRFPFLMY IL*VFIRFVGHITYQLSQMSVCNCVSFTL*NFV QHK*VKKSLFFSTFSKSRIVNIVDSFSV*CVLLF HNAVTCRNIVYLFSAYLMS*FLKSINIPVSHSP AVP*S*LLRVVGGDWRAHCRPRGPPGWLSTFGS WYFQSSGFQFLGFAALMMKCVFDASEKLSLAGYK ILLQEIPSNLLFVPKQLAYHASKFC*LQALSLG KQKNQSIISRWERFFY*KFIPDNSAFRKEIKCA TSRGAALQLFRARARQDK*MGGTGGSCLRTTSGH *PLVDNCE*LGFPPPAVQLPVL*GWTNLSSGAN *LYSPPHAPPIRSLHLVSLLLQVDALLLILHLL QGRLGPHWTGCQDVKAYGSFKETSWWFHAGGSAI PADLAWCLCVSTHVHVGWGKRVYR*R*ISWGLL *TALCVRSILKLPVK*LDYFYLGISDYRSSLMF YVQIL*PLVTVSELIRYPLINSTDLAVY*SITNL FSRTQRM*HLYCSFPGLLVFCTDEF*QGNCHFT CAILL*ITADF*TIFYVNFIKIKLSTSF

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG PYLPTDRATR*S*RQSRR*RGQLPPRQPSGPAG PTCQPWPFCYQIPAFHLYEKILPAVSILQWVFL F*HRQEPSTHEL*QINTNPKSSLPGLQPLSQCNG *LGLETAPSPSFHEAG*TCRYAPRDMDRPRVAA YWRRV*RLLCKEDASST*LRTTVADADLLDTRR EASSADSRSQEDGQGMAADDPLMGIFE*LPSSRR PPTNGYLTTVTLHCPPGVENALTGSLRSRDTMQ TFCLFKPTRPSTAVSWCHYYAASGSLVEGAGDV SEDTELDGTTFLFITTQQNF*WKFVVNVKEGAFF AF*YTNHGFLEQDFV*EWCLHAVCFPPHLQ*GF SKRKWKLFNQFVNNFCIKILRTYGLFSEDYVTP AVETEPANLKSCLSLFLEITEFLNRETCDILPPF PTIASLTFLNYF*YQKSSFEMELIKRAEGLLPA CIDIPVPFVNIYVPL*IQLHLWQNFRLFLRLSS SLFVMQLQSGLRCIDLVQCIFMIK*N*VRTRVNI CLYLAQFERSVINWEAFGVGFHSISTSMLLGSI LKRQ*Q**QQT*VLRPFVLLAFLVAGFPMVTGC TVSIRSQRATVSITAESSCSIQLTPSWELAQAWG RASDGHLLGLLHFSPTHSPLASLL*IHFETGLI PLPPAP*KNNSGQKSVFFHFSRTVGYCQATCDP SHVVRVLFLCACSL*VQWKEATHWSVISEAADAQ GDPRKSQVREQ*K*GGKTIL*TL*LLKFLKTPS LNNF*KK*LNFQMSKQCHQLVFCPIEEPACSRY LN*VEKSKHFYLHNLKNIYVYIAYSLFPLGRDDF NPNTLTLKNFLSPRISLGL*LIFKAVLELILFP DVSRAHW*GHTKPTVTSSGRIAAVGLLDTHIHQ RCIWIWAPPPRIPVLTCQSPD*STLLCFLSPAAP GSTHWVQPWARHGRPCPVLPRGCVHHMSTFPSG LAASRLAVETVPEEIRDSMNCRSIKDQAVGTRT *SDDWMSLYCMYLVIKMPLCRKYASRGYTFLPFL KNIFVEKIIKSPFWKLTAGFVP*QPLPM*GL*K VSCDLTQKRNKHTQNSFMSDSSDALPNWLVDQE FWGWGLRRNQV*NSF*LKKYSGIQLSAVSPS*CI YCEYLLDS*VILLIN*AKCLCAIVFPLPCKILY SINK*KNHCFSQLFQNQGL*IL*ILFLCDVSYC FIML*LVEILYIYFLLI*CLNF*KVLTSLSPTPL PSHEVNS*ELSGVTGELIADHVVLQGGSPPSGP GISSQVGFNSWALPPL**SVCLMPVRNSVWQAT KFYSKKYPATFCLFQSN*LIMQANFADSRLYL*E NKKTKVLSAGGKDFSIENLSLTTQRLEKK*NVP LPEVLHCSCSGLGPGRTSEWVGQVAPA*GPPQA TNPLWTTVSSWVFPHLLCNFLCFEVGLTCLQELI NCTALPTPHPYGHCIWSACFFRSMPSF*YSISF RGGWGPTGLGVKM*KLMGALRRLHGGSMQVVLP SLLI*PGACVCPLTYTWGGGNVSTDDAKSVGVYS KQHCV*EASSSSQLSNLTTFIWEFQTIEALLCF MSRFCDH*LLYQNSSGTHL*IALIWLYTDPSLT CFLGPSVCSICIAVSLAYLCFALMNFDRVIATLL VQYCCK*LQIFKQSFMLIL*K*NFQLV

Sequence BCL2L11.fAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG CCCCTACCTCCCTACAGACAGAGCCACAAGGTAATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGC CCCACCTGCCAGCCCTGGCCCTTTTGCTACCAGATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCT TTTGACACAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGG CTAACTGGGACTAGAAACAGCTCCATCACCCAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCG TATTGGAGACGAGTTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTA CGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAG CACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTT CTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGG AGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATT TGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGC TGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATT ATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATAT TTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTC AGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTG TTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGAC TTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTG TCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCC TGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTC TGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCC TGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGC AGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTT TCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTAT CTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCC TTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATAC AAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGG ATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCA GGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGT TCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATG TATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAAT CCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAA ACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTT TAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCA TATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTC TCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTAT ATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGT CGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTG GGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTC TGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTG GGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGG GCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGG GTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCAT ACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGT CAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGT CCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAA GCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTA TCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGT ATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTT TTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT

113317 (forward primer)
BCL2L11-4 (reverse primer)
Intron retention

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG APTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLA PPASPGPFATRSPLFIFMRRSSLLSRSSSGYFS FDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM ANWD*KQLHHPASMRQAEPADMRPEIWIAQELRR IGDEFNAYYARRVFLNNYQAAEDHPRMVILRLL RYIVRLVWRMH*QVLCGAEIPCRHFACSNQQDP APRSPGAIIMQPAVLLWRGQVTFQKTPSWMGLPF CSSPHSRISNGSLL*M*RREHSLLFNIQTMVFW SRILCKNGVYMQCVFPLTFNKVFQKGNGNFLTN L*ITFVLKF*EPTAYSQRIM*PLQWKLSQLT*KA ALVYF*RLQNF*TGRRVIYSLPSLLLPL*PF*I IFNTKRVLLKWN*LKGQRVCCQPALIYQSHL*I FTYLYKFSCICGKISDYFCVFPHHFL*CNSSLDS DA*IWSSVFS**SEIESEQELISACILHSSSDL LLTGKHLVLVFIPFRRACYWEVF*RGNSSNNNR LKCYAPLCCWLFWLQAFPWSQDALSASGPRGPPC PLQQSPAAASSSRPHGNWHRPGAGLLMAICLAS CILVQLTVH*LHSFKFTLKQASSHFHQHHRRII LGRSLFFFIFPGQLDIVRPLVTPAM**GCSFSVP APYECSGRKPHTGQSFQRQQMPRETQERVRLGS SESEEGRQFCELCNS*NF*KLHR*TTFKRNN*I FK*VSSATN*CFAR*KSQHVHVI*IRWKNLNIFI FII*KIYMYILHIHFFL*VEMISIQILLL*KIS FPQESPWDFDLFLKLCWSSSCSLMCLEPIGRVI QSPRLQAVVGLQPWACWTHTYTKDVFGSGHPLPG SLYSRASLLTRALYSVSSALQPLGAHTGCSPGP GTGGPALCCPGAVCTT*AHFPLAWRPPGWLWKQ FLRKLEIL*IVGVLKTRLLAPELKAMTGCLCTVC IWLSRCLCAESMPPVGIRFYLF*KTFL*KK*LN PLFGNLLQVLCLDNLSLCEVCKKCPVT*HRNAI NTHKIVS*VILQMPFPTG*LIKNFGGGGCGEIKF KIPSD*KNIVEYNCLPFPLLNVYIVSIY*IRRS YYLSTEPNVCVQLCFLYLVKFCTA*ISKKITVF LNFFKIKDCKYCRFFFCVMCPTVS*CCNL*KYCI FIFCLFNVLISEKY*HPCLPLPCRPMKLTPESC RG*LESSLQTTWSSRVALHLRVLVFPVKWVSIL GLCRPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPS VCSKATSLSCKQILLTPGFIFRKTKKPKYYQQV GKIFLLKIYP*QLSV*KRNKMCHFQRCCIAVVQ G*GQAGQVNGWDRWLLPKDHLRPLTPCGQL*VAG FSPTCCATSCALRLD*LVFRS*LTVQPSPRPTH TVTAFGQPASSGRCPPSDTPSPSGEVGAPLDWV SRCESLWEL*GDFMVVPCRWFCHPC*FSLVPVCV HSRTRGVGETCLQMTLNQLGSTLNSIVCKKHPQ APS*VT*LLLFGNFRL*KLSYVLCPDSVTTSYC IRTHQVPTYK*H*SGCILIHH*PVF*DPAYVAFV LQFPWLTCVLH**ILTG*LPLYLCNTAVNNCRF LNNLLC*FYKNKTFN*F

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG PLPPYRQSHKVILKAITEVKGTAAPTAALRARW PHLPALALLLPDPRFSSL*EDPPCCLDPPVGISL LTQTGAQHP*VVTNQHKPQVLLARPSTTISVQW LTGTRNSSITQLP*GRLNLQICAQRYGSPKSCG VLETSLTLTMQGGYF*IITKQPKTTHEWLSYDCY VTLSAWCGECIDRFFAEPRYHADILLVQTNKTQ HRGLLVPLLCSQRFSCGGGR*RFRRHRAGWDYL SVHHHTAEFLMEVCCECKGGSILCFLIYKPWFFG AGFCVRMVFTCSVFSPSPSIRFFKKEMETF*PI CE*LLY*NFKNLRPILRGLCNPCSGN*AS*LKK LP*FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKL FLIPKEFF*NGTD*KGRGSVASLH*YTSPICKY LRTFINSVASVAKFQTIFASFLITFCDATPVWT QMHRFGPVYFHDKVKLSQNKS*YLPVSCTVRAIC Y*LGSIWCWFSFHFDEHVIGKYSEEAIAVITTD LSATPLCAAGFSGCRLSHGHRMHCQHQVPEGHR VHYSRVQLQHPAHALMGIGTGLGQGF*WPFAWPP AF*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*F WAEVCFFSFFQDSWILSGHL*PQPCSEGALSLC LLLMSAVEGSHTLVSHFRGSRCPGRPKKESG*GA VKVRREDNSVNSVTLKIFENSIVKQLLKEITKF SNE*AVPPTSVLPDRRASMFTLFKLGGKI*TFL SS*FKKYICIYCIFTFSFR*R*FQSKYSYFKKFP FPKNLLGTLTYF*SCVGAHLVP*CVSSPLVGSY KAHGYKQW*DCSRGPAGHTHTPKMYLDLGTPSQ DPCTHVPVS*LEHFTLFPQPCSPWEHTLGAALGQ AREALPCAAQGLCAPHEHISLWPGGLQAGCGNS S*GN*RFYEL*EY*RPGCWHQNLKR*LDVSVLY VSGYQDASVQKVCLPWVYVFTFFKKHFCRKNN*I PFLETYCRFCALTTSPYVRFVKSVL*LNTETQ* THTK*FHE*FFRCPSQLVS*SRILGVGVAEKSS LKFLLIKKI*WNTIVCRFPFLMYIL*VFIRFVGH ITYQLSQMSVCNCVSFTL*NFVQHK*VKKSLFF STFSKSRIVNIVDSFSV*CVLLFHNAVTCRNIV YLFSAYLMS*FLKSINIPVSHSPAVP*S*LLRVV GGDWRAHCRPRGPPGWLSTFGSWYFQSSGFQFL GFAALMMKCVFDASEKLSLAGYKILLQEIPSNL LFVPKQLAYHASKFC*LQALSLGKQKNQSIISRW ERFFY*KFIPDNSAFRKEIKCATSRGAALQLFR ARARQDK*MGGTGGSCLRTTSGH*PLVDNCE*L GFPPPAVQLPVL*GWTNLSSGAN*LYSPPHAPPI RSLHLVSLLLQVDALLLILHLLQGRLGPHWTGC QDVKAYGSFKETSWWFHAGGSAIPADLAWCLCV STHVHVGWGKRVYR*R*ISWGLL*TALCVRSILK LPVK*LDYFYLGISDYRSSLMFYVQIL*PLVTV SELIRYPLINSTDLAVY*SITNLFSRTQRM*HL YCSFPGLLVFCTDEF*QGNCHFTCAILL*ITADF *TIFYVNFIKIKLSTSF

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG PYLPTDRATR*S*RQSRR*RGQLPPRQPSGPAG PTCQPWPFCYQIPAFHLYEKILPAVSILQWVFL F*HRQEPSTHEL*QINTNPKSSLPGLQPLSQCNG *LGLETAPSPSFHEAG*TCRYAPRDMDRPRVAA YWRRV*RLLCKEGIFE*LPSSRRPPTNGYLTTV TLHCPPGVENALTGSLRSRDTMQTFCLFKPTRPS TAVSWCHYYAASGSLVEGAGDVSEDTELDGTTF LFITTQQNF*WKFVVNVKEGAFFAF*YTNHGFL EQDFV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQF VNNFCIKILRTYGLFSEDYVTPAVETEPANLKS CLSLFLEITEFLNRETCDILPPFPTIASLTFLN YF*YQKSSFEMELIKRAEGLLPACIDIPVPFVNI YVPL*IQLHLWQNFRLFLRLSSSLFVMQLQSGL RCIDLVQCIFMIK*N*VRTRVNICLYLAQFERS VINWEAFGVGFHSISTSMLLGSILKRQ*Q**QQT *VLRPFVLLAFLVAGFPMVTGCTVSIRSQRATV SITAESSCSIQLTPSWELAQAWGRASDGHLLGL LHFSPTHSPLASLL*IHFETGLIPLPPAP*KNNS GQKSVFFHFSRTVGYCQATCDPSHVVRVLFLCA CSL*VQWKEATHWSVISEAADAQGDPRKSQVRE Q*K*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNF QMSKQCHQLVFCPIEEPACSRYLN*VEKSKHFY LHNLKNIYVYIAYSLFPLGRDDFNPNTLTLKNF LSPRISLGL*LIFKAVLELILFPDVSRAHW*GHT KPTVTSSGRIAAVGLLDTHIHQRCIWIWAPPPR IPVLTCQSPD*STLLCFLSPAAPGSTHWVQPWA RHGRPCPVLPRGCVHHMSTFPSGLAASRLAVETV PEEIRDSMNCRSIKDQAVGTRT*SDDWMSLYCM YLVIKMPLCRKYASRGYTFLPFLKNIFVEKIIK SPFWKLTAGFVP*QPLPM*GL*KVSCDLTQKRNK HTQNSFMSDSSDALPNWLVDQEFWGWGLRRNQV *NSF*LKKYSGIQLSAVSPS*CIYCEYLLDS*V ILLIN*AKCLCAIVFPLPCKILYSINK*KNHCFS QLFQNQGL*IL*ILFLCDVSYCFIML*LVEILY IYFLLI*CLNF*KVLTSLSPTPLPSHEVNS*EL SGVTGELIADHVVLQGGSPPSGPGISSQVGFNSW ALPPL**SVCLMPVRNSVWQATKFYSKKYPATF CLFQSN*LIMQANFADSRLYL*ENKKTKVLSAG GKDFSIENLSLTTQRLEKK*NVPLPEVLHCSCSG LGPGRTSEWVGQVAPA*GPPQATNPLWTTVSSW VFPHLLCNFLCFEVGLTCLQELINCTALPTPHP YGHCIWSACFFRSMPSF*YSISFRGGWGPTGLGV KM*KLMGALRRLHGGSMQVVLPSLLI*PGACVC PLTYTWGGGNVSTDDAKSVGVYSKQHCV*EASS SSQLSNLTTFIWEFQTIEALLCFMSRFCDH*LLY QNSSGTHL*IALIWLYTDPSLTCFLGPSVCSIC IAVSLAYLCFALMNFDRVIATLLVQYCCK*LQI FKQSFMLIL*K*NFQLV

Sequence BCL2L11.cAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG CCCCTACCTCCCTACAGACAGAGCCACAAGGTAATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGC CCCACCTGCCAGCCCTGGCCCTTTTGCTACCAGATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCT TTTGACACAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGG CTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAGTTTAACGCTTACTATGCAAG GAGGTTAGAGAAATAGAGGAAGTTGTCGTGTAGTTGTCATGTATTCAGTCCACTTAAGGGCAGTGGGGAAGCGTTTGAGACGGAGCTGTGGAGGCTGAAT CCTTGAAGGAGGAGGTGAGAGAGGCACAGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTACGTTACAT TGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGG TCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTCAT CACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGGAT TTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATA ACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAG TTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTTAA TACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATTTACGTAC CTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCAT AGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAAC TGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGTGC TACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATTAC AGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTT AGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGA AGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCCTT ATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAG TGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGA GTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAA TTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCCCA AGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCCCA CGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGT ACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGG AGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGAGG AAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTGGT TATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTT TGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAACACACAC AAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAATTC CTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCATATTACTT ATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTT TTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTT TCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGGTG ACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTTGC CGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTT CCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGAT TTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGGGC CAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTCCC CCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCAC TGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGT GAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTCAC GTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCCAG TTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACT CATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGT TTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAACAA TCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT

113317 (forward primer)
BCL2L11-4 (reverse primer)
Intron retention

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG APTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLA PPASPGPFATRSPLFIFMRRSSLLSRSSSGYFS FDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM ASMRQAEPADMRPEIWIAQELRRIGDEFNAYYAR RLEK*RKLSCSCHVFSPLKGSGEAFETELWRLN P*RRR*ERHRYF*IITKQPKTTHEWLSYDCYVT LSAWCGECIDRFFAEPRYHADILLVQTNKTQHRG LLVPLLCSQRFSCGGGR*RFRRHRAGWDYLSVH HHTAEFLMEVCCECKGGSILCFLIYKPWFFGAG FCVRMVFTCSVFSPSPSIRFFKKEMETF*PICE* LLY*NFKNLRPILRGLCNPCSGN*AS*LKKLP* FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKLFL IPKEFF*NGTD*KGRGSVASLH*YTSPICKYLRT FINSVASVAKFQTIFASFLITFCDATPVWTQMH RFGPVYFHDKVKLSQNKS*YLPVSCTVRAICY* LGSIWCWFSFHFDEHVIGKYSEEAIAVITTDLSA TPLCAAGFSGCRLSHGHRMHCQHQVPEGHRVHY SRVQLQHPAHALMGIGTGLGQGF*WPFAWPPAF *SNSQSTSFTPLNSL*NRPHPTSTSTIEE*FWAE VCFFSFFQDSWILSGHL*PQPCSEGALSLCLLL MSAVEGSHTLVSHFRGSRCPGRPKKESG*GAVK VRREDNSVNSVTLKIFENSIVKQLLKEITKFSNE *AVPPTSVLPDRRASMFTLFKLGGKI*TFLSS* FKKYICIYCIFTFSFR*R*FQSKYSYFKKFPFP KNLLGTLTYF*SCVGAHLVP*CVSSPLVGSYKAH GYKQW*DCSRGPAGHTHTPKMYLDLGTPSQDPC THVPVS*LEHFTLFPQPCSPWEHTLGAALGQAR EALPCAAQGLCAPHEHISLWPGGLQAGCGNSS*G N*RFYEL*EY*RPGCWHQNLKR*LDVSVLYVSG YQDASVQKVCLPWVYVFTFFKKHFCRKNN*IPF LETYCRFCALTTSPYVRFVKSVL*LNTETQ*THT K*FHE*FFRCPSQLVS*SRILGVGVAEKSSLKF LLIKKI*WNTIVCRFPFLMYIL*VFIRFVGHIT YQLSQMSVCNCVSFTL*NFVQHK*VKKSLFFSTF SKSRIVNIVDSFSV*CVLLFHNAVTCRNIVYLF SAYLMS*FLKSINIPVSHSPAVP*S*LLRVVGG DWRAHCRPRGPPGWLSTFGSWYFQSSGFQFLGFA ALMMKCVFDASEKLSLAGYKILLQEIPSNLLFV PKQLAYHASKFC*LQALSLGKQKNQSIISRWER FFY*KFIPDNSAFRKEIKCATSRGAALQLFRARA RQDK*MGGTGGSCLRTTSGH*PLVDNCE*LGFP PPAVQLPVL*GWTNLSSGAN*LYSPPHAPPIRS LHLVSLLLQVDALLLILHLLQGRLGPHWTGCQDV KAYGSFKETSWWFHAGGSAIPADLAWCLCVSTH VHVGWGKRVYR*R*ISWGLL*TALCVRSILKLP VK*LDYFYLGISDYRSSLMFYVQIL*PLVTVSEL IRYPLINSTDLAVY*SITNLFSRTQRM*HLYCS FPGLLVFCTDEF*QGNCHFTCAILL*ITADF*T IFYVNFIKIKLSTSF

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG PLPPYRQSHKVILKAITEVKGTAAPTAALRARW PHLPALALLLPDPRFSSL*EDPPCCLDPPVGISL LTQTGAQHP*VVTNQHKPQVLLARPSTTISVQW LP*GRLNLQICAQRYGSPKSCGVLETSLTLTMQ GG*RNRGSCRVVVMYSVHLRAVGKRLRRSCGG*I LEGGGERGTGIFE*LPSSRRPPTNGYLTTVTLH CPPGVENALTGSLRSRDTMQTFCLFKPTRPSTA VSWCHYYAASGSLVEGAGDVSEDTELDGTTFLFI TTQQNF*WKFVVNVKEGAFFAF*YTNHGFLEQD FV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQFVN NFCIKILRTYGLFSEDYVTPAVETEPANLKSCLS LFLEITEFLNRETCDILPPFPTIASLTFLNYF* YQKSSFEMELIKRAEGLLPACIDIPVPFVNIYV PL*IQLHLWQNFRLFLRLSSSLFVMQLQSGLRCI DLVQCIFMIK*N*VRTRVNICLYLAQFERSVIN WEAFGVGFHSISTSMLLGSILKRQ*Q**QQT*V LRPFVLLAFLVAGFPMVTGCTVSIRSQRATVSIT AESSCSIQLTPSWELAQAWGRASDGHLLGLLHF SPTHSPLASLL*IHFETGLIPLPPAP*KNNSGQ KSVFFHFSRTVGYCQATCDPSHVVRVLFLCACSL *VQWKEATHWSVISEAADAQGDPRKSQVREQ*K *GGKTIL*TL*LLKFLKTPSLNNF*KK*LNFQM SKQCHQLVFCPIEEPACSRYLN*VEKSKHFYLHN LKNIYVYIAYSLFPLGRDDFNPNTLTLKNFLSP RISLGL*LIFKAVLELILFPDVSRAHW*GHTKP TVTSSGRIAAVGLLDTHIHQRCIWIWAPPPRIPV LTCQSPD*STLLCFLSPAAPGSTHWVQPWARHG RPCPVLPRGCVHHMSTFPSGLAASRLAVETVPE EIRDSMNCRSIKDQAVGTRT*SDDWMSLYCMYLV IKMPLCRKYASRGYTFLPFLKNIFVEKIIKSPF WKLTAGFVP*QPLPM*GL*KVSCDLTQKRNKHT QNSFMSDSSDALPNWLVDQEFWGWGLRRNQV*NS F*LKKYSGIQLSAVSPS*CIYCEYLLDS*VILL IN*AKCLCAIVFPLPCKILYSINK*KNHCFSQL FQNQGL*IL*ILFLCDVSYCFIML*LVEILYIYF LLI*CLNF*KVLTSLSPTPLPSHEVNS*ELSGV TGELIADHVVLQGGSPPSGPGISSQVGFNSWAL PPL**SVCLMPVRNSVWQATKFYSKKYPATFCLF QSN*LIMQANFADSRLYL*ENKKTKVLSAGGKD FSIENLSLTTQRLEKK*NVPLPEVLHCSCSGLG PGRTSEWVGQVAPA*GPPQATNPLWTTVSSWVFP HLLCNFLCFEVGLTCLQELINCTALPTPHPYGH CIWSACFFRSMPSF*YSISFRGGWGPTGLGVKM *KLMGALRRLHGGSMQVVLPSLLI*PGACVCPLT YTWGGGNVSTDDAKSVGVYSKQHCV*EASSSSQ LSNLTTFIWEFQTIEALLCFMSRFCDH*LLYQN SSGTHL*IALIWLYTDPSLTCFLGPSVCSICIAV SLAYLCFALMNFDRVIATLLVQYCCK*LQIFKQ SFMLIL*K*NFQLV

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG PYLPTDRATR*S*RQSRR*RGQLPPRQPSGPAG PTCQPWPFCYQIPAFHLYEKILPAVSILQWVFL F*HRQEPSTHEL*QINTNPKSSLPGLQPLSQCNG FHEAG*TCRYAPRDMDRPRVAAYWRRV*RLLCK EVREIEEVVV*LSCIQST*GQWGSV*DGAVEAE SLKEEVREAQVFLNNYQAAEDHPRMVILRLLRYI VRLVWRMH*QVLCGAEIPCRHFACSNQQDPAPR SPGAIIMQPAVLLWRGQVTFQKTPSWMGLPFCS SPHSRISNGSLL*M*RREHSLLFNIQTMVFWSRI LCKNGVYMQCVFPLTFNKVFQKGNGNFLTNL*I TFVLKF*EPTAYSQRIM*PLQWKLSQLT*KAAL VYF*RLQNF*TGRRVIYSLPSLLLPL*PF*IIFN TKRVLLKWN*LKGQRVCCQPALIYQSHL*IFTY LYKFSCICGKISDYFCVFPHHFL*CNSSLDSDA *IWSSVFS**SEIESEQELISACILHSSSDLLLT GKHLVLVFIPFRRACYWEVF*RGNSSNNNRLKC YAPLCCWLFWLQAFPWSQDALSASGPRGPPCPL QQSPAAASSSRPHGNWHRPGAGLLMAICLASCIL VQLTVH*LHSFKFTLKQASSHFHQHHRRIILGR SLFFFIFPGQLDIVRPLVTPAM**GCSFSVPAP YECSGRKPHTGQSFQRQQMPRETQERVRLGSSES EEGRQFCELCNS*NF*KLHR*TTFKRNN*IFK* VSSATN*CFAR*KSQHVHVI*IRWKNLNIFIFI I*KIYMYILHIHFFL*VEMISIQILLL*KISFPQ ESPWDFDLFLKLCWSSSCSLMCLEPIGRVIQSP RLQAVVGLQPWACWTHTYTKDVFGSGHPLPGSL YSRASLLTRALYSVSSALQPLGAHTGCSPGPGTG GPALCCPGAVCTT*AHFPLAWRPPGWLWKQFLR KLEIL*IVGVLKTRLLAPELKAMTGCLCTVCIW LSRCLCAESMPPVGIRFYLF*KTFL*KK*LNPLF GNLLQVLCLDNLSLCEVCKKCPVT*HRNAINTH KIVS*VILQMPFPTG*LIKNFGGGGCGEIKFKI PSD*KNIVEYNCLPFPLLNVYIVSIY*IRRSYYL STEPNVCVQLCFLYLVKFCTA*ISKKITVFLNF FKIKDCKYCRFFFCVMCPTVS*CCNL*KYCIFI FCLFNVLISEKY*HPCLPLPCRPMKLTPESCRG* LESSLQTTWSSRVALHLRVLVFPVKWVSILGLC RPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPSVC SKATSLSCKQILLTPGFIFRKTKKPKYYQQVGKI FLLKIYP*QLSV*KRNKMCHFQRCCIAVVQG*G QAGQVNGWDRWLLPKDHLRPLTPCGQL*VAGFS PTCCATSCALRLD*LVFRS*LTVQPSPRPTHTVT AFGQPASSGRCPPSDTPSPSGEVGAPLDWVSRC ESLWEL*GDFMVVPCRWFCHPC*FSLVPVCVHS RTRGVGETCLQMTLNQLGSTLNSIVCKKHPQAPS *VT*LLLFGNFRL*KLSYVLCPDSVTTSYCIRT HQVPTYK*H*SGCILIHH*PVF*DPAYVAFVLQ FPWLTCVLH**ILTG*LPLYLCNTAVNNCRFLNN LLC*FYKNKTFN*F

Sequence BCL2L11.bAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG CCCCTACCTCCCTACAGACAGAGCCACAAGGTAATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGC CCCACCTGCCAGCCCTGGCCCTTTTGCTACCAGATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCT TTTGACACAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGG CTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAGTTTAACGCTTACTATGCAAG GAGGATGCCTCTTCCACCTGATTAAGAACCACTGTAGCAGACGCAGACTTATTGGACACTAGGCGGGAGGCCAGCTCTGCAGACAGCAGGTCTCAGGAAG ACGGTCAAGGCATGGCTGCTGATGATCCGCTTATGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTAC GTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGC ACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTC TGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGA GCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTT GTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCT GCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTA TTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATT TACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCA GATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGT TATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACT TAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGT CCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCT GCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCT GGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCT GCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCA GTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTT CAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATC TTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCT TTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACA AAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGA TCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAG GCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTT CCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGT ATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATC CCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAA CACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTT AAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCAT ATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCT CAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATA TTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTC GGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGG GCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCT GTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGG GAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGG CTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGG TTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATA CGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTC AAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTC CACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAG CTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTAT CAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTA TTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTT TAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT

113317 (forward primer)
BCL2L11-4 (reverse primer)
Intron retention

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG APTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLA PPASPGPFATRSPLFIFMRRSSLLSRSSSGYFS FDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM ASMRQAEPADMRPEIWIAQELRRIGDEFNAYYAR RMPLPPD*EPL*QTQTYWTLGGRPALQTAGLRK TVKAWLLMIRLWVFLNNYQAAEDHPRMVILRLL RYIVRLVWRMH*QVLCGAEIPCRHFACSNQQDPA PRSPGAIIMQPAVLLWRGQVTFQKTPSWMGLPF CSSPHSRISNGSLL*M*RREHSLLFNIQTMVFW SRILCKNGVYMQCVFPLTFNKVFQKGNGNFLTNL *ITFVLKF*EPTAYSQRIM*PLQWKLSQLT*KA ALVYF*RLQNF*TGRRVIYSLPSLLLPL*PF*I IFNTKRVLLKWN*LKGQRVCCQPALIYQSHL*IF TYLYKFSCICGKISDYFCVFPHHFL*CNSSLDS DA*IWSSVFS**SEIESEQELISACILHSSSDL LLTGKHLVLVFIPFRRACYWEVF*RGNSSNNNRL KCYAPLCCWLFWLQAFPWSQDALSASGPRGPPC PLQQSPAAASSSRPHGNWHRPGAGLLMAICLAS CILVQLTVH*LHSFKFTLKQASSHFHQHHRRIIL GRSLFFFIFPGQLDIVRPLVTPAM**GCSFSVP APYECSGRKPHTGQSFQRQQMPRETQERVRLGS SESEEGRQFCELCNS*NF*KLHR*TTFKRNN*IF K*VSSATN*CFAR*KSQHVHVI*IRWKNLNIFI FII*KIYMYILHIHFFL*VEMISIQILLL*KIS FPQESPWDFDLFLKLCWSSSCSLMCLEPIGRVIQ SPRLQAVVGLQPWACWTHTYTKDVFGSGHPLPG SLYSRASLLTRALYSVSSALQPLGAHTGCSPGP GTGGPALCCPGAVCTT*AHFPLAWRPPGWLWKQF LRKLEIL*IVGVLKTRLLAPELKAMTGCLCTVC IWLSRCLCAESMPPVGIRFYLF*KTFL*KK*LN PLFGNLLQVLCLDNLSLCEVCKKCPVT*HRNAIN THKIVS*VILQMPFPTG*LIKNFGGGGCGEIKF KIPSD*KNIVEYNCLPFPLLNVYIVSIY*IRRS YYLSTEPNVCVQLCFLYLVKFCTA*ISKKITVFL NFFKIKDCKYCRFFFCVMCPTVS*CCNL*KYCI FIFCLFNVLISEKY*HPCLPLPCRPMKLTPESC RG*LESSLQTTWSSRVALHLRVLVFPVKWVSILG LCRPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPS VCSKATSLSCKQILLTPGFIFRKTKKPKYYQQV GKIFLLKIYP*QLSV*KRNKMCHFQRCCIAVVQG *GQAGQVNGWDRWLLPKDHLRPLTPCGQL*VAG FSPTCCATSCALRLD*LVFRS*LTVQPSPRPTH TVTAFGQPASSGRCPPSDTPSPSGEVGAPLDWVS RCESLWEL*GDFMVVPCRWFCHPC*FSLVPVCV HSRTRGVGETCLQMTLNQLGSTLNSIVCKKHPQ APS*VT*LLLFGNFRL*KLSYVLCPDSVTTSYCI RTHQVPTYK*H*SGCILIHH*PVF*DPAYVAFV LQFPWLTCVLH**ILTG*LPLYLCNTAVNNCRF LNNLLC*FYKNKTFN*F

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG PLPPYRQSHKVILKAITEVKGTAAPTAALRARW PHLPALALLLPDPRFSSL*EDPPCCLDPPVGISL LTQTGAQHP*VVTNQHKPQVLLARPSTTISVQW LP*GRLNLQICAQRYGSPKSCGVLETSLTLTMQ GGCLFHLIKNHCSRRRLIGH*AGGQLCRQQVSGR RSRHGC**SAYGYF*IITKQPKTTHEWLSYDCY VTLSAWCGECIDRFFAEPRYHADILLVQTNKTQ HRGLLVPLLCSQRFSCGGGR*RFRRHRAGWDYLS VHHHTAEFLMEVCCECKGGSILCFLIYKPWFFG AGFCVRMVFTCSVFSPSPSIRFFKKEMETF*PI CE*LLY*NFKNLRPILRGLCNPCSGN*AS*LKKL P*FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKL FLIPKEFF*NGTD*KGRGSVASLH*YTSPICKY LRTFINSVASVAKFQTIFASFLITFCDATPVWTQ MHRFGPVYFHDKVKLSQNKS*YLPVSCTVRAIC Y*LGSIWCWFSFHFDEHVIGKYSEEAIAVITTD LSATPLCAAGFSGCRLSHGHRMHCQHQVPEGHRV HYSRVQLQHPAHALMGIGTGLGQGF*WPFAWPP AF*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*F WAEVCFFSFFQDSWILSGHL*PQPCSEGALSLCL LLMSAVEGSHTLVSHFRGSRCPGRPKKESG*GA VKVRREDNSVNSVTLKIFENSIVKQLLKEITKF SNE*AVPPTSVLPDRRASMFTLFKLGGKI*TFLS S*FKKYICIYCIFTFSFR*R*FQSKYSYFKKFP FPKNLLGTLTYF*SCVGAHLVP*CVSSPLVGSY KAHGYKQW*DCSRGPAGHTHTPKMYLDLGTPSQD PCTHVPVS*LEHFTLFPQPCSPWEHTLGAALGQ AREALPCAAQGLCAPHEHISLWPGGLQAGCGNS S*GN*RFYEL*EY*RPGCWHQNLKR*LDVSVLYV SGYQDASVQKVCLPWVYVFTFFKKHFCRKNN*I PFLETYCRFCALTTSPYVRFVKSVL*LNTETQ* THTK*FHE*FFRCPSQLVS*SRILGVGVAEKSSL KFLLIKKI*WNTIVCRFPFLMYIL*VFIRFVGH ITYQLSQMSVCNCVSFTL*NFVQHK*VKKSLFF STFSKSRIVNIVDSFSV*CVLLFHNAVTCRNIVY LFSAYLMS*FLKSINIPVSHSPAVP*S*LLRVV GGDWRAHCRPRGPPGWLSTFGSWYFQSSGFQFL GFAALMMKCVFDASEKLSLAGYKILLQEIPSNLL FVPKQLAYHASKFC*LQALSLGKQKNQSIISRW ERFFY*KFIPDNSAFRKEIKCATSRGAALQLFR ARARQDK*MGGTGGSCLRTTSGH*PLVDNCE*LG FPPPAVQLPVL*GWTNLSSGAN*LYSPPHAPPI RSLHLVSLLLQVDALLLILHLLQGRLGPHWTGC QDVKAYGSFKETSWWFHAGGSAIPADLAWCLCVS THVHVGWGKRVYR*R*ISWGLL*TALCVRSILK LPVK*LDYFYLGISDYRSSLMFYVQIL*PLVTV SELIRYPLINSTDLAVY*SITNLFSRTQRM*HLY CSFPGLLVFCTDEF*QGNCHFTCAILL*ITADF *TIFYVNFIKIKLSTSF

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG PYLPTDRATR*S*RQSRR*RGQLPPRQPSGPAG PTCQPWPFCYQIPAFHLYEKILPAVSILQWVFL F*HRQEPSTHEL*QINTNPKSSLPGLQPLSQCNG FHEAG*TCRYAPRDMDRPRVAAYWRRV*RLLCK EDASST*LRTTVADADLLDTRREASSADSRSQE DGQGMAADDPLMGIFE*LPSSRRPPTNGYLTTVT LHCPPGVENALTGSLRSRDTMQTFCLFKPTRPS TAVSWCHYYAASGSLVEGAGDVSEDTELDGTTF LFITTQQNF*WKFVVNVKEGAFFAF*YTNHGFLE QDFV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQF VNNFCIKILRTYGLFSEDYVTPAVETEPANLKS CLSLFLEITEFLNRETCDILPPFPTIASLTFLNY F*YQKSSFEMELIKRAEGLLPACIDIPVPFVNI YVPL*IQLHLWQNFRLFLRLSSSLFVMQLQSGL RCIDLVQCIFMIK*N*VRTRVNICLYLAQFERSV INWEAFGVGFHSISTSMLLGSILKRQ*Q**QQT *VLRPFVLLAFLVAGFPMVTGCTVSIRSQRATV SITAESSCSIQLTPSWELAQAWGRASDGHLLGLL HFSPTHSPLASLL*IHFETGLIPLPPAP*KNNS GQKSVFFHFSRTVGYCQATCDPSHVVRVLFLCA CSL*VQWKEATHWSVISEAADAQGDPRKSQVREQ *K*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNF QMSKQCHQLVFCPIEEPACSRYLN*VEKSKHFY LHNLKNIYVYIAYSLFPLGRDDFNPNTLTLKNFL SPRISLGL*LIFKAVLELILFPDVSRAHW*GHT KPTVTSSGRIAAVGLLDTHIHQRCIWIWAPPPR IPVLTCQSPD*STLLCFLSPAAPGSTHWVQPWAR HGRPCPVLPRGCVHHMSTFPSGLAASRLAVETV PEEIRDSMNCRSIKDQAVGTRT*SDDWMSLYCM YLVIKMPLCRKYASRGYTFLPFLKNIFVEKIIKS PFWKLTAGFVP*QPLPM*GL*KVSCDLTQKRNK HTQNSFMSDSSDALPNWLVDQEFWGWGLRRNQV *NSF*LKKYSGIQLSAVSPS*CIYCEYLLDS*VI LLIN*AKCLCAIVFPLPCKILYSINK*KNHCFS QLFQNQGL*IL*ILFLCDVSYCFIML*LVEILY IYFLLI*CLNF*KVLTSLSPTPLPSHEVNS*ELS GVTGELIADHVVLQGGSPPSGPGISSQVGFNSW ALPPL**SVCLMPVRNSVWQATKFYSKKYPATF CLFQSN*LIMQANFADSRLYL*ENKKTKVLSAGG KDFSIENLSLTTQRLEKK*NVPLPEVLHCSCSG LGPGRTSEWVGQVAPA*GPPQATNPLWTTVSSW VFPHLLCNFLCFEVGLTCLQELINCTALPTPHPY GHCIWSACFFRSMPSF*YSISFRGGWGPTGLGV KM*KLMGALRRLHGGSMQVVLPSLLI*PGACVC PLTYTWGGGNVSTDDAKSVGVYSKQHCV*EASSS SQLSNLTTFIWEFQTIEALLCFMSRFCDH*LLY QNSSGTHL*IALIWLYTDPSLTCFLGPSVCSIC IAVSLAYLCFALMNFDRVIATLLVQYCCK*LQIF KQSFMLIL*K*NFQLV

Sequence BCL2L11.aAug05

GCCGCCTGGTCTGCAGTTTGTTGGAGCTCTGCGTCCAGCGCCGCTGCCGCTGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCACTACCA CCACTTGATTCTTGCAGCCACCCTGCGAACCCTGCCACACTGCGATCGCATCATCGCGGTATTCGGTTCGCTGCGTTCCCGCCGCCACCGCCTCGGCGCC CTTTCTTGGCCCTTGTTCCCCCAAATGTCTGACTCTGACTCTCGGACTGAGAAACGCAAGAAAAAAAGACCAAATGGCAAAGCAACCTTCTGATGTAAGT TCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGGTA ATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGCCCCACCTGCCAGCCCTGGCCCTTTTGCTACCAG ATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCTTTTGACACAGACAGGAGCCCAGCACCCATGAGT TGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGGCTTCCATGAGGCAGGCTGAACCTGCAGATATGC GCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAGTTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGA AGACCACCCACGAATGGTTATCTTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGC AGACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGT TTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTC TTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTT TTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCC TGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCC TTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAG CCTGCATTGATATACCAGTCCCATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTC ATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAAT ATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTA TTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATG CACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGG GGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCA TCCCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCC CAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCC CAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCAT CGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTA TTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGAT TTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCC CTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCA AAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCC CCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTG GCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAAC TTAAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTT TTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAA AAGTGTCCTGTGACTTAACACAGAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGA ATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGT ATATATTGTGAGTATTTATTAGATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGT ACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTG TTTCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCC CTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTC CTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTAC AAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAG GAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGC CACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGC CACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTA ATTAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCT TCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCC ATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTAC TCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTT TTATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAAC CTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTA CTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT

113317 (forward primer)
BCL2L11-4 (reverse primer)
Intron retention

Frame 0

AAWSAVCWSSASSAAAAAAAAAAAAAAAAAATT TT*FLQPPCEPCHTAIASSRYSVRCVPAATASAP FLGPCSPKCLTLTLGLRNARKKDQMAKQPSDVS SECDREGRQLQPAERPPQLRPGAPTSLQTEPQG NPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATR SPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMS CDKSTQTPSPPCQAFNHYLSAMASMRQAEPADM RPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAE DHPRMVILRLLRYIVRLVWRMH*QVLCGAEIPC RHFACSNQQDPAPRSPGAIIMQPAVLLWRGQVT FQKTPSWMGLPFCSSPHSRISNGSLL*M*RREHS LLFNIQTMVFWSRILCKNGVYMQCVFPLTFNKV FQKGNGNFLTNL*ITFVLKF*EPTAYSQRIM*P LQWKLSQLT*KAALVYF*RLQNF*TGRRVIYSLP SLLLPL*PF*IIFNTKRVLLKWN*LKGQRVCCQ PALIYQSHL*IFTYLYKFSCICGKISDYFCVFP HHFL*CNSSLDSDA*IWSSVFS**SEIESEQELI SACILHSSSDLLLTGKHLVLVFIPFRRACYWEV F*RGNSSNNNRLKCYAPLCCWLFWLQAFPWSQD ALSASGPRGPPCPLQQSPAAASSSRPHGNWHRPG AGLLMAICLASCILVQLTVH*LHSFKFTLKQAS SHFHQHHRRIILGRSLFFFIFPGQLDIVRPLVT PAM**GCSFSVPAPYECSGRKPHTGQSFQRQQMP RETQERVRLGSSESEEGRQFCELCNS*NF*KLH R*TTFKRNN*IFK*VSSATN*CFAR*KSQHVHV I*IRWKNLNIFIFII*KIYMYILHIHFFL*VEMI SIQILLL*KISFPQESPWDFDLFLKLCWSSSCS LMCLEPIGRVIQSPRLQAVVGLQPWACWTHTYT KDVFGSGHPLPGSLYSRASLLTRALYSVSSALQP LGAHTGCSPGPGTGGPALCCPGAVCTT*AHFPL AWRPPGWLWKQFLRKLEIL*IVGVLKTRLLAPE LKAMTGCLCTVCIWLSRCLCAESMPPVGIRFYLF *KTFL*KK*LNPLFGNLLQVLCLDNLSLCEVCK KCPVT*HRNAINTHKIVS*VILQMPFPTG*LIK NFGGGGCGEIKFKIPSD*KNIVEYNCLPFPLLNV YIVSIY*IRRSYYLSTEPNVCVQLCFLYLVKFC TA*ISKKITVFLNFFKIKDCKYCRFFFCVMCPT VS*CCNL*KYCIFIFCLFNVLISEKY*HPCLPLP CRPMKLTPESCRG*LESSLQTTWSSRVALHLRV LVFPVKWVSILGLCRPYDEVCV*CQ*ETQSGRL QNSTPRNTQQPSVCSKATSLSCKQILLTPGFIFR KTKKPKYYQQVGKIFLLKIYP*QLSV*KRNKMC HFQRCCIAVVQG*GQAGQVNGWDRWLLPKDHLR PLTPCGQL*VAGFSPTCCATSCALRLD*LVFRS* LTVQPSPRPTHTVTAFGQPASSGRCPPSDTPSP SGEVGAPLDWVSRCESLWEL*GDFMVVPCRWFC HPC*FSLVPVCVHSRTRGVGETCLQMTLNQLGST LNSIVCKKHPQAPS*VT*LLLFGNFRL*KLSYV LCPDSVTTSYCIRTHQVPTYK*H*SGCILIHH* PVF*DPAYVAFVLQFPWLTCVLH**ILTG*LPLY LCNTAVNNCRFLNNLLC*FYKNKTFN*F

Frame 1

PPGLQFVGALRPAPLPLPPPPPPPPPPPPPPLP PLDSCSHPANPATLRSHHRGIRFAAFPPPPPRR PFLALVPPNV*L*LSD*ETQEKKTKWQSNLLM*V LSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKV ILKAITEVKGTAAPTAALRARWPHLPALALLLP DPRFSSL*EDPPCCLDPPVGISLLTQTGAQHP*V VTNQHKPQVLLARPSTTISVQWLP*GRLNLQIC AQRYGSPKSCGVLETSLTLTMQGGYF*IITKQP KTTHEWLSYDCYVTLSAWCGECIDRFFAEPRYHA DILLVQTNKTQHRGLLVPLLCSQRFSCGGGR*R FRRHRAGWDYLSVHHHTAEFLMEVCCECKGGSI LCFLIYKPWFFGAGFCVRMVFTCSVFSPSPSIRF FKKEMETF*PICE*LLY*NFKNLRPILRGLCNP CSGN*AS*LKKLP*FIFRDYRIFKQGDV*YTPS LPYYCLSDLFKLFLIPKEFF*NGTD*KGRGSVAS LH*YTSPICKYLRTFINSVASVAKFQTIFASFL ITFCDATPVWTQMHRFGPVYFHDKVKLSQNKS* YLPVSCTVRAICY*LGSIWCWFSFHFDEHVIGKY SEEAIAVITTDLSATPLCAAGFSGCRLSHGHRM HCQHQVPEGHRVHYSRVQLQHPAHALMGIGTGL GQGF*WPFAWPPAF*SNSQSTSFTPLNSL*NRPH PTSTSTIEE*FWAEVCFFSFFQDSWILSGHL*P QPCSEGALSLCLLLMSAVEGSHTLVSHFRGSRC PGRPKKESG*GAVKVRREDNSVNSVTLKIFENSI VKQLLKEITKFSNE*AVPPTSVLPDRRASMFTL FKLGGKI*TFLSS*FKKYICIYCIFTFSFR*R* FQSKYSYFKKFPFPKNLLGTLTYF*SCVGAHLVP *CVSSPLVGSYKAHGYKQW*DCSRGPAGHTHTP KMYLDLGTPSQDPCTHVPVS*LEHFTLFPQPCS PWEHTLGAALGQAREALPCAAQGLCAPHEHISLW PGGLQAGCGNSS*GN*RFYEL*EY*RPGCWHQN LKR*LDVSVLYVSGYQDASVQKVCLPWVYVFTF FKKHFCRKNN*IPFLETYCRFCALTTSPYVRFVK SVL*LNTETQ*THTK*FHE*FFRCPSQLVS*SR ILGVGVAEKSSLKFLLIKKI*WNTIVCRFPFLM YIL*VFIRFVGHITYQLSQMSVCNCVSFTL*NFV QHK*VKKSLFFSTFSKSRIVNIVDSFSV*CVLL FHNAVTCRNIVYLFSAYLMS*FLKSINIPVSHS PAVP*S*LLRVVGGDWRAHCRPRGPPGWLSTFGS WYFQSSGFQFLGFAALMMKCVFDASEKLSLAGY KILLQEIPSNLLFVPKQLAYHASKFC*LQALSL GKQKNQSIISRWERFFY*KFIPDNSAFRKEIKCA TSRGAALQLFRARARQDK*MGGTGGSCLRTTSG H*PLVDNCE*LGFPPPAVQLPVL*GWTNLSSGA N*LYSPPHAPPIRSLHLVSLLLQVDALLLILHLL QGRLGPHWTGCQDVKAYGSFKETSWWFHAGGSA IPADLAWCLCVSTHVHVGWGKRVYR*R*ISWGL L*TALCVRSILKLPVK*LDYFYLGISDYRSSLMF YVQIL*PLVTVSELIRYPLINSTDLAVY*SITN LFSRTQRM*HLYCSFPGLLVFCTDEF*QGNCHF TCAILL*ITADF*TIFYVNFIKIKLSTSF

Frame 2

RLVCSLLELCVQRRCRCRRRRRRRRRRRRRHYH HLILAATLRTLPHCDRIIAVFGSLRSRRHRLGA LSWPLFPQMSDSDSRTEKRKKKRPNGKATF*CK F*V*PRR*TIAACGEASPAQTWGPYLPTDRATR* S*RQSRR*RGQLPPRQPSGPAGPTCQPWPFCYQ IPAFHLYEKILPAVSILQWVFLF*HRQEPSTHE L*QINTNPKSSLPGLQPLSQCNGFHEAG*TCRYA PRDMDRPRVAAYWRRV*RLLCKEGIFE*LPSSR RPPTNGYLTTVTLHCPPGVENALTGSLRSRDTM QTFCLFKPTRPSTAVSWCHYYAASGSLVEGAGDV SEDTELDGTTFLFITTQQNF*WKFVVNVKEGAF FAF*YTNHGFLEQDFV*EWCLHAVCFPPHLQ*G FSKRKWKLFNQFVNNFCIKILRTYGLFSEDYVTP AVETEPANLKSCLSLFLEITEFLNRETCDILPP FPTIASLTFLNYF*YQKSSFEMELIKRAEGLLP ACIDIPVPFVNIYVPL*IQLHLWQNFRLFLRLSS SLFVMQLQSGLRCIDLVQCIFMIK*N*VRTRVN ICLYLAQFERSVINWEAFGVGFHSISTSMLLGS ILKRQ*Q**QQT*VLRPFVLLAFLVAGFPMVTGC TVSIRSQRATVSITAESSCSIQLTPSWELAQAW GRASDGHLLGLLHFSPTHSPLASLL*IHFETGL IPLPPAP*KNNSGQKSVFFHFSRTVGYCQATCDP SHVVRVLFLCACSL*VQWKEATHWSVISEAADA QGDPRKSQVREQ*K*GGKTIL*TL*LLKFLKTP SLNNF*KK*LNFQMSKQCHQLVFCPIEEPACSRY LN*VEKSKHFYLHNLKNIYVYIAYSLFPLGRDD FNPNTLTLKNFLSPRISLGL*LIFKAVLELILF PDVSRAHW*GHTKPTVTSSGRIAAVGLLDTHIHQ RCIWIWAPPPRIPVLTCQSPD*STLLCFLSPAA PGSTHWVQPWARHGRPCPVLPRGCVHHMSTFPS GLAASRLAVETVPEEIRDSMNCRSIKDQAVGTRT *SDDWMSLYCMYLVIKMPLCRKYASRGYTFLPF LKNIFVEKIIKSPFWKLTAGFVP*QPLPM*GL* KVSCDLTQKRNKHTQNSFMSDSSDALPNWLVDQE FWGWGLRRNQV*NSF*LKKYSGIQLSAVSPS*C IYCEYLLDS*VILLIN*AKCLCAIVFPLPCKIL YSINK*KNHCFSQLFQNQGL*IL*ILFLCDVSYC FIML*LVEILYIYFLLI*CLNF*KVLTSLSPTP LPSHEVNS*ELSGVTGELIADHVVLQGGSPPSG PGISSQVGFNSWALPPL**SVCLMPVRNSVWQAT KFYSKKYPATFCLFQSN*LIMQANFADSRLYL* ENKKTKVLSAGGKDFSIENLSLTTQRLEKK*NV PLPEVLHCSCSGLGPGRTSEWVGQVAPA*GPPQA TNPLWTTVSSWVFPHLLCNFLCFEVGLTCLQEL INCTALPTPHPYGHCIWSACFFRSMPSF*YSIS FRGGWGPTGLGVKM*KLMGALRRLHGGSMQVVLP SLLI*PGACVCPLTYTWGGGNVSTDDAKSVGVY SKQHCV*EASSSSQLSNLTTFIWEFQTIEALLC FMSRFCDH*LLYQNSSGTHL*IALIWLYTDPSLT CFLGPSVCSICIAVSLAYLCFALMNFDRVIATL LVQYCCK*LQIFKQSFMLIL*K*NFQLV