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Sequences

Sequence BIRC5.eAug05

CGCCTCTACTCCCAGAAGGCCGCGGGGGGTGGACCGCCTAAGAGGGCGTGCGCTCCCGACATGCCCCGCGGCGCGCCATTAACCGCCAGATTTGAATCGC GGGACCCGTTGGCAGAGGTGGCGGCGGCGGCATGGGTGCCCCGACGTTGCCCCCTGCCTGGCAGCCCTTTCTCAAGGACCACCGCATCTCTACATTCAAG AACTGGCCCTTCTTGGAGGGCTGCGCCTGCACCCCGGAGCGGATGGCCGAGGCTGGCTTCATCCACTGCCCCACTGAGAACGAGCCAGACTTGGCCCAGT GTTTCTTCTGCTTCAAGGAGCTGGAAGGCTGGGAGCCAGATGACGACCCCATAGAGGAACATAAAAAGCATTCGTCCGGTTGCGCTTTCCTTTCTGTCAA GAAGCAGTTTGAAGAATTAACCCTTGGTGAATTTTTGAAACTGGACAGAGAAAGAGCCAAGAACAAAATTGAGAGAGCTCTGTTAGCAGAATGAAAAAAT TGGAAGCCAGATTCAGGGAGGGACTGGAAGCAAAAGAATTTCTGTTCGAGGAAGAGCCTGATGTTTGCCAGGGTCTGTTTAACTGGACATGAAGAGGAAG GCTCTGGACTTTCCTCCAGGAGTTTCAGGAGAAAGGCAAAGGAAACCAACAATAAGAAGAAAGAATTTGAGGAAACTGCGGAGAAAGTGCGCCGTGCCAT CGAGCAGCTGGCTGCCATGGATTGAGGCCTCTGGCCGGAGCTGCCTGGTCCCAGAGTGGCTGCACCACTTCCAGGGTTTATTCCCTGGTGCCACCAGCCT TCCTGTGGGCCCCTTAGCAATGTCTTAGGAAAGGAGATCAACATTTTCAAATTAGATGTTTCAACTGTGCTCTTGTTTTGTCTTGAAAGTGGCACCAGAG GTGCTTCTGCCTGTGCAGCGGGTGCTGCTGGTAACAGTGGCTGCTTCTCTCTCTCTCTCTCTTTTTTGGGGGCTCATTTTTGCTGTTTTGATTCCCGGGC TTACCAGGTGAGAAGTGAGGGAGGAAGAAGGCAGTGTCCCTTTTGCTAGAGCTGACAGCTTTGTTCGCGTGGGCAGAGCCTTCCACAGTGAATGTGTCTG GACCTCATGTTGTTGAGGCTGTCACAGTCCTGAGTGTGGACTTGGCAGGTGCCTGTTGAATCTGAGCTGCAGGTTCCTTATCTGTCACACCTGTGCCTCC TCAGAGGACAGTTTTTTTGTTGTTGTGTTTTTTTGTTTTTTTTTTTTTGGTAGATGCATGACTTGTGTGTGATGAGAGAATGGAGACAGAGTCCCTGGCT CCTCTACTGTTTAACAACATGGCTTTCTTATTTTGTTTGAATTGTTAATTCACAGAATAGCACAAACTACAATTAAAACTAAGCACAAAGCCATTCTAAG TCATTGGGGAAACGGGGTGAACTTCAGGTGGATGAGGAGACAGAATAGAGTGATAGGAAGCGTCTGGCAGATACTCCTTTTGCCACTGCTGTGTGATTAG ACAGGCCCAGTGAGCCGCGGGGCACATGCTGGCCGCTCCTCCCTCAGAAAAAGGCAGTGGCCTAAATCCTTTTTAAATGACTTGGCTCGATGCTGTGGGG GACTGGCTGGGCTGCTGCAGGCCGTGTGTCTGTCAGCCCAACCTTCACATCTGTCACGTTCTCCACACGGGGGAGAGACGCAGTCCGCCCAGGTCCCCGC TTTCTTTGGAGGCAGCAGCTCCCGCAGGGCTGAAGTCTGGCGTAAGATGATGGATTTGATTCGCCCTCCTCCCTGTCATAGAGCTGCAGGGTGGATTGTT ACAGCTTCGCTGGAAACCTCTGGAGGTCATCTCGGCTGTTCCTGAGAAATAAAAAGCCTGTCATTTCAAACACTGCTGTGGACCCTACTGGGTTTTTAAA ATATTGTCAGTTTTTCATCGTCGTCCCTAGCCTGCCAACAGCCATCTGCCCAGACAGCCGCAGTGAGGATGAGCGTCCTGGCAGAGACGCAGTTGTCTCT GGGCGCTTGCCAGAGCCACGAACCCCAGACCTGTTTGTATCATCCGGGCTCCTTCCGGGCAGAAACAACTGAAAATGCACTTCAGACCCACTTATTTCTG CCACATCTGAGTCGGCCTGAGATAGACTTTTCCCTCTAAACTGGGAGAATATCACAGTGGTTTTTGTTAGCAGAAAATGCACTCCAGCCTCTGTACTCAT CTAAGCTGCTTATTTTTGATATTTGTGTCAGTCTGTAAATGGATACTTCACTTTAATAACTGTTGCTTAGTAATTGGCTTTGTAGAGAAGCTGGAAAAAA ATGGTTTTGTCTTCAACTCCTTTGCATGCCAGGCGGTGATGTGGATCTCGGCTTCTGTGAGCCTGTGCTGTGGGCAGGGCTGAGCTGGAGCCGCCCCTCT CAGCCCGCCTGCCACGGCCTTTCCTTAAAGGCCATCCTTAAAACCAGACCCTCATGGCTACCAGCACCTGAAAGCTTCCTCGACATCTGTTAATAAAGCC GTAGGCCCTTGTCTAAGTGCAACCGCCTAGACTTTCTTTCAGATACATGTCCACATGTCCATTTTTCAGGTTCTCTAAGTTGGAGTGGAGTCTGGGAAGG GTTGTGAATGAGGCTTCTGGGCTATGGGTGAGGTTCCAATGGCAGGTTAGAGCCCCTCGGGCCAACTGCCATCCTGGAAAGTAGAGACAGCAGTGCCCGC TGCCCAGAAGAGACCAGCAAGCCAAACTGGAGCCCCCATTGCAGGCTGTCGCCATGTGGAAAGAGTAACTCACAATTGCCAATAAAGTCTCATGTGGTTT TATCT

primer-1293 (forward primer)
primer-1294 (reverse primer)
Single exon skipping

Frame 0

RLYSQKAAGGGPPKRACAPDMPRGAPLTARFES RDPLAEVAAAAWVPRRCPLPGSPFSRTTASLHSR TGPSWRAAPAPRSGWPRLASSTAPLRTSQTWPS VSSASRSWKAGSQMTTP*RNIKSIRPVALSFLS RSSLKN*PLVNF*NWTEKEPRTKLRELC*QNEKI GSQIQGGTGSKRISVRGRA*CLPGSV*LDMKRK ALDFPPGVSGERQRKPTIRRKNLRKLRRKCAVP SSSWLPWIEASGRSCLVPEWLHHFQGLFPGATSL PVGPLAMS*ERRSTFSN*MFQLCSCFVLKVAPE VLLPVQRVLLVTVAASLSLSLFWGLIFAVLIPG LTR*EVREEEGSVPFARADSFVRVGRAFHSECVW TSCC*GCHSPECGLGRCLLNLSCRFLICHTCAS SEDSFFVVVFFCFFFFGRCMTCV**ENGDRVPG SSTV*QHGFLILFELLIHRIAQTTIKTKHKAILS HWGNGVNFRWMRRQNRVIGSVWQILLLPLLCD* TGPVSRGAHAGRSSLRKRQWPKSFLNDLARCCG GLAGLLQAVCLSAQPSHLSRSPHGGETQSAQVPA FFGGSSSRRAEVWRKMMDLIRPPPCHRAAGWIV TASLETSGGHLGCS*EIKSLSFQTLLWTLLGF* NIVSFSSSSLACQQPSAQTAAVRMSVLAETQLSL GACQSHEPQTCLYHPGSFRAETTENALQTHLFL PHLSRPEIDFSL*TGRISQWFLLAENALQPLYS SKLLIFDICVSL*MDTSL**LLLSNWLCREAGKK WFCLQLLCMPGGDVDLGFCEPVLWAGLSWSRPS QPACHGLSLKAILKTRPSWLPAPESFLDIC**S RRPLSKCNRLDFLSDTCPHVHFSGSLSWSGVWEG L*MRLLGYG*GSNGRLEPLGPTAILESRDSSAR CPEETSKPNWSPHCRLSPCGKSNSQLPIKSHVV LS

Frame 1

ASTPRRPRGVDRLRGRALPTCPAARH*PPDLNR GTRWQRWRRRHGCPDVAPCLAALSQGPPHLYIQ ELALLGGLRLHPGADGRGWLHPLPH*ERARLGPV FLLLQGAGRLGAR*RPHRGT*KAFVRLRFPFCQ EAV*RINPW*IFETGQRKSQEQN*ESSVSRMKK LEARFREGLEAKEFLFEEEPDVCQGLFNWT*RGR LWTFLQEFQEKGKGNQQ*EERI*GNCGESAPCH RAAGCHGLRPLAGAAWSQSGCTTSRVYSLVPPA FLWAP*QCLRKGDQHFQIRCFNCALVLS*KWHQR CFCLCSGCCW*QWLLLSLSLFFGGSFLLF*FPG LPGEK*GRKKAVSLLLELTALFAWAEPSTVNVS GPHVVEAVTVLSVDLAGAC*I*AAGSLSVTPVPP QRTVFLLLCFFVFFFLVDA*LVCDERMETESLA PLLFNNMAFLFCLNC*FTE*HKLQLKLSTKPF* VIGETG*TSGG*GDRIE**EASGRYSFCHCCVIR QAQ*AAGHMLAAPPSEKGSGLNPF*MTWLDAVG DWLGCCRPCVCQPNLHICHVLHTGERRSPPRSP LSLEAAAPAGLKSGVR*WI*FALLPVIELQGGLL QLRWKPLEVISAVPEK*KACHFKHCCGPYWVFK ILSVFHRRP*PANSHLPRQPQ*G*ASWQRRSCL WALARATNPRPVCIIRAPSGQKQLKMHFRPTYFC HI*VGLR*TFPSKLGEYHSGFC*QKMHSSLCTH LSCLFLIFVSVCKWILHFNNCCLVIGFVEKLEK NGFVFNSFACQAVMWISASVSLCCGQG*AGAAPL SPPATAFP*RPSLKPDPHGYQHLKASSTSVNKA VGPCLSATA*TFFQIHVHMSIFQVL*VGVESGK GCE*GFWAMGEVPMAG*SPSGQLPSWKVETAVPA AQKRPASQTGAPIAGCRHVERVTHNCQ*SLMWF Y

Frame 2

PLLPEGRGGWTA*EGVRSRHAPRRAINRQI*IA GPVGRGGGGGMGAPTLPPAWQPFLKDHRISTFK NWPFLEGCACTPERMAEAGFIHCPTENEPDLAQ CFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVK KQFEELTLGEFLKLDRERAKNKIERALLAE*KN WKPDSGRDWKQKNFCSRKSLMFARVCLTGHEEE GSGLSSRSFRRKAKETNNKKKEFEETAEKVRRAI EQLAAMD*GLWPELPGPRVAAPLPGFIPWCHQP SCGPLSNVLGKEINIFKLDVSTVLLFCLESGTR GASACAAGAAGNSGCFSLSLSFLGAHFCCFDSRA YQVRSEGGRRQCPFC*S*QLCSRGQSLPQ*MCL DLMLLRLSQS*VWTWQVPVESELQVPYLSHLCL LRGQFFCCCVFLFFFFW*MHDLCVMREWRQSPWL LYCLTTWLSYFV*IVNSQNSTNYN*N*AQSHSK SLGKRGELQVDEETE*SDRKRLADTPFATAV*L DRPSEPRGTCWPLLPQKKAVA*ILFK*LGSMLWG TGWAAAGRVSVSPTFTSVTFSTRGRDAVRPGPR FLWRQQLPQG*SLA*DDGFDSPSSLS*SCRVDC YSFAGNLWRSSRLFLRNKKPVISNTAVDPTGFLK YCQFFIVVPSLPTAICPDSRSEDERPGRDAVVS GRLPEPRTPDLFVSSGLLPGRNN*KCTSDPLIS ATSESA*DRLFPLNWENITVVFVSRKCTPASVLI *AAYF*YLCQSVNGYFTLITVA**LAL*RSWKK MVLSSTPLHARR*CGSRLL*ACAVGRAELEPPL SARLPRPFLKGHP*NQTLMATST*KLPRHLLIKP *ALV*VQPPRLSFRYMSTCPFFRFSKLEWSLGR VVNEASGLWVRFQWQVRAPRANCHPGK*RQQCP LPRRDQQAKLEPPLQAVAMWKE*LTIANKVSCGF I

Sequence BIRC5.cAug05

CGCCTCTACTCCCAGAAGGCCGCGGGGGGTGGACCGCCTAAGAGGGCGTGCGCTCCCGACATGCCCCGCGGCGCGCCATTAACCGCCAGATTTGAATCGC GGGACCCGTTGGCAGAGGTGGCGGCGGCGGCATGGGTGCCCCGACGTTGCCCCCTGCCTGGCAGCCCTTTCTCAAGGACCACCGCATCTCTACATTCAAG AACTGGCCCTTCTTGGAGGGCTGCGCCTGCACCCCGGAGCGGATGGCCGAGGCTGGCTTCATCCACTGCCCCACTGAGAACGAGCCAGACTTGGCCCAGT GTTTCTTCTGCTTCAAGGAGCTGGAAGGCTGGGAGCCAGATGACGACCCCATAGAGGAACATAAAAAGCATTCGTCCGGTTGCGCTTTCCTTTCTGTCAA GAAGCAGTTTGAAGAATTAACCCTTGGTGAATTTTTGAAACTGGACAGAGAAAGAGCCAAGAACAAAATTGCAAAGGAAACCAACAATAAGAAGAAAGAA TTTGAGGAAACTGCGGAGAAAGTGCGCCGTGCCATCGAGCAGCTGGCTGCCATGGATTGAGGCCTCTGGCCGGAGCTGCCTGGTCCCAGAGTGGCTGCAC CACTTCCAGGGTTTATTCCCTGGTGCCACCAGCCTTCCTGTGGGCCCCTTAGCAATGTCTTAGGAAAGGAGATCAACATTTTCAAATTAGATGTTTCAAC TGTGCTCTTGTTTTGTCTTGAAAGTGGCACCAGAGGTGCTTCTGCCTGTGCAGCGGGTGCTGCTGGTAACAGTGGCTGCTTCTCTCTCTCTCTCTCTTTT TTGGGGGCTCATTTTTGCTGTTTTGATTCCCGGGCTTACCAGGTGAGAAGTGAGGGAGGAAGAAGGCAGTGTCCCTTTTGCTAGAGCTGACAGCTTTGTT CGCGTGGGCAGAGCCTTCCACAGTGAATGTGTCTGGACCTCATGTTGTTGAGGCTGTCACAGTCCTGAGTGTGGACTTGGCAGGTGCTGGCTGGGCTGCT GCAGGCCGTGTGTCTGTCAGCCCAACCTTCACATCTGTCACGTTCTCCACACGGGGGAGAGACGCAGTCCGCCCAGGTCCCCGCTTTCTTTGGAGGCAGC AGCTCCCGCAGGGCTGAAGTCTGGCGTAAGATGATGGATTTGATTCGCCCTCCTCCCTGTCATAGAGCTGCAGGGTGGATTGTTACAGCTTCGCTGGAAA CCTCTGGAGGTCATCTCGGCTGTTCCTGAGAAATAAAAAGCCTGTCATTTCAAACACTGCTGTGGACCCTACTGGGTTTTTAAAATATTGTCAGTTTTTC ATCGTCGTCCCTAGCCTGCCAACAGCCATCTGCCCAGACAGCCGCAGTGAGGATGAGCGTCCTGGCAGAGACGCAGTTGTCTCTGGGCGCTTGCCAGAGC CACGAACCCCAGACCTGTTTGTATCATCCGGGCTCCTTCCGGGCAGAAACAACTGAAAATGCACTTCAGACCCACTTATTTCTGCCACATCTGAGTCGGC CTGAGATAGACTTTTCCCTCTAAACTGGGAGAATATCACAGTGGTTTTTGTTAGCAGAAAATGCACTCCAGCCTCTGTACTCATCTAAGCTGCTTATTTT TGATATTTGTGTCAGTCTGTAAATGGATACTTCACTTTAATAACTGTTGCTTAGTAATTGGCTTTGTAGAGAAGCTGGAAAAAAATGGTTTTGTCTTCAA CTCCTTTGCATGCCAGGCGGTGATGTGGATCTCGGCTTCTGTGAGCCTGTGCTGTGGGCAGGGCTGAGCTGGAGCCGCCCCTCTCAGCCCGCCTGCCACG GCCTTTCCTTAAAGGCCATCCTTAAAACCAGACCCTCATGGCTACCAGCACCTGAAAGCTTCCTCGACATCTGTTAATAAAGCCGTAGGCCCTTGTCTAA GTGCAACCGCCTAGACTTTCTTTCAGATACATGTCCACATGTCCATTTTTCAGGTTCTCTAAGTTGGAGTGGAGTCTGGGAAGGGTTGTGAATGAGGCTT CTGGGCTATGGGTGAGGTTCCAATGGCAGGTTAGAGCCCCTCGGGCCAACTGCCATCCTGGAAAGTAGAGACAGCAGTGCCCGCTGCCCAGAAGAGACCA GCAAGCCAAACTGGAGCCCCCATTGCAGGCTGTCGCCATGTGGAAAGAGTAACTCACAATTGCCAATAAAGTCTCATGTGGTTTTATCT

primer-1293 (forward primer)
primer-1294 (reverse primer)
Single exon skipping

Frame 0

RLYSQKAAGGGPPKRACAPDMPRGAPLTARFES RDPLAEVAAAAWVPRRCPLPGSPFSRTTASLHSR TGPSWRAAPAPRSGWPRLASSTAPLRTSQTWPS VSSASRSWKAGSQMTTP*RNIKSIRPVALSFLS RSSLKN*PLVNF*NWTEKEPRTKLQRKPTIRRKN LRKLRRKCAVPSSSWLPWIEASGRSCLVPEWLH HFQGLFPGATSLPVGPLAMS*ERRSTFSN*MFQ LCSCFVLKVAPEVLLPVQRVLLVTVAASLSLSLF WGLIFAVLIPGLTR*EVREEEGSVPFARADSFV RVGRAFHSECVWTSCC*GCHSPECGLGRCWLGC CRPCVCQPNLHICHVLHTGERRSPPRSPLSLEAA APAGLKSGVR*WI*FALLPVIELQGGLLQLRWK PLEVISAVPEK*KACHFKHCCGPYWVFKILSVF HRRP*PANSHLPRQPQ*G*ASWQRRSCLWALARA TNPRPVCIIRAPSGQKQLKMHFRPTYFCHI*VG LR*TFPSKLGEYHSGFC*QKMHSSLCTHLSCLF LIFVSVCKWILHFNNCCLVIGFVEKLEKNGFVFN SFACQAVMWISASVSLCCGQG*AGAAPLSPPAT AFP*RPSLKPDPHGYQHLKASSTSVNKAVGPCL SATA*TFFQIHVHMSIFQVL*VGVESGKGCE*GF WAMGEVPMAG*SPSGQLPSWKVETAVPAAQKRP ASQTGAPIAGCRHVERVTHNCQ*SLMWFY

Frame 1

ASTPRRPRGVDRLRGRALPTCPAARH*PPDLNR GTRWQRWRRRHGCPDVAPCLAALSQGPPHLYIQ ELALLGGLRLHPGADGRGWLHPLPH*ERARLGPV FLLLQGAGRLGAR*RPHRGT*KAFVRLRFPFCQ EAV*RINPW*IFETGQRKSQEQNCKGNQQ*EER I*GNCGESAPCHRAAGCHGLRPLAGAAWSQSGCT TSRVYSLVPPAFLWAP*QCLRKGDQHFQIRCFN CALVLS*KWHQRCFCLCSGCCW*QWLLLSLSLF FGGSFLLF*FPGLPGEK*GRKKAVSLLLELTALF AWAEPSTVNVSGPHVVEAVTVLSVDLAGAGWAA AGRVSVSPTFTSVTFSTRGRDAVRPGPRFLWRQ QLPQG*SLA*DDGFDSPSSLS*SCRVDCYSFAGN LWRSSRLFLRNKKPVISNTAVDPTGFLKYCQFF IVVPSLPTAICPDSRSEDERPGRDAVVSGRLPE PRTPDLFVSSGLLPGRNN*KCTSDPLISATSESA *DRLFPLNWENITVVFVSRKCTPASVLI*AAYF *YLCQSVNGYFTLITVA**LAL*RSWKKMVLSS TPLHARR*CGSRLL*ACAVGRAELEPPLSARLPR PFLKGHP*NQTLMATST*KLPRHLLIKP*ALV* VQPPRLSFRYMSTCPFFRFSKLEWSLGRVVNEA SGLWVRFQWQVRAPRANCHPGK*RQQCPLPRRDQ QAKLEPPLQAVAMWKE*LTIANKVSCGFI

Frame 2

PLLPEGRGGWTA*EGVRSRHAPRRAINRQI*IA GPVGRGGGGGMGAPTLPPAWQPFLKDHRISTFK NWPFLEGCACTPERMAEAGFIHCPTENEPDLAQ CFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVK KQFEELTLGEFLKLDRERAKNKIAKETNNKKKE FEETAEKVRRAIEQLAAMD*GLWPELPGPRVAA PLPGFIPWCHQPSCGPLSNVLGKEINIFKLDVST VLLFCLESGTRGASACAAGAAGNSGCFSLSLSF LGAHFCCFDSRAYQVRSEGGRRQCPFC*S*QLC SRGQSLPQ*MCLDLMLLRLSQS*VWTWQVLAGLL QAVCLSAQPSHLSRSPHGGETQSAQVPAFFGGS SSRRAEVWRKMMDLIRPPPCHRAAGWIVTASLE TSGGHLGCS*EIKSLSFQTLLWTLLGF*NIVSFS SSSLACQQPSAQTAAVRMSVLAETQLSLGACQS HEPQTCLYHPGSFRAETTENALQTHLFLPHLSR PEIDFSL*TGRISQWFLLAENALQPLYSSKLLIF DICVSL*MDTSL**LLLSNWLCREAGKKWFCLQ LLCMPGGDVDLGFCEPVLWAGLSWSRPSQPACH GLSLKAILKTRPSWLPAPESFLDIC**SRRPLSK CNRLDFLSDTCPHVHFSGSLSWSGVWEGL*MRL LGYG*GSNGRLEPLGPTAILESRDSSARCPEET SKPNWSPHCRLSPCGKSNSQLPIKSHVVLS

Sequence BIRC5.bAug05

CGCCTCTACTCCCAGAAGGCCGCGGGGGGTGGACCGCCTAAGAGGGCGTGCGCTCCCGACATGCCCCGCGGCGCGCCATTAACCGCCAGATTTGAATCGC GGGACCCGTTGGCAGAGGTGGCGGCGGCGGCATGGGTGCCCCGACGTTGCCCCCTGCCTGGCAGCCCTTTCTCAAGGACCACCGCATCTCTACATTCAAG AACTGGCCCTTCTTGGAGGGCTGCGCCTGCACCCCGGAGCGGATGGCCGAGGCTGGCTTCATCCACTGCCCCACTGAGAACGAGCCAGACTTGGCCCAGT GTTTCTTCTGCTTCAAGGAGCTGGAAGGCTGGGAGCCAGATGACGACCCCATAGAGGAACATAAAAAGCATTCGTCCGGTTGCGCTTTCCTTTCTGTCAA GAAGCAGTTTGAAGAATTAACCCTTGGTGAATTTTTGAAACTGGACAGAGAAAGAGCCAAGAACAAAATTGCAAAGGAAACCAACAATAAGAAGAAAGAA TTTGAGGAAACTGCGGAGAAAGTGCGCCGTGCCATCGAGCAGCTGGCTGCCATGGATTGAGGCCTCTGGCCGGAGCTGCCTGGTCCCAGAGTGGCTGCAC CACTTCCAGGGTTTATTCCCTGGTGCCACCAGCCTTCCTGTGGGCCCCTTAGCAATGTCTTAGGAAAGGAGATCAACATTTTCAAATTAGATGTTTCAAC TGTGCTCTTGTTTTGTCTTGAAAGTGGCACCAGAGGTGCTTCTGCCTGTGCAGCGGGTGCTGCTGGTAACAGTGGCTGCTTCTCTCTCTCTCTCTCTTTT TTGGGGGCTCATTTTTGCTGTTTTGATTCCCGGGCTTACCAGGTGAGAAGTGAGGGAGGAAGAAGGCAGTGTCCCTTTTGCTAGAGCTGACAGCTTTGTT CGCGTGGGCAGAGCCTTCCACAGTGAATGTGTCTGGACCTCATGTTGTTGAGGCTGTCACAGTCCTGAGTGTGGACTTGGCAGGTGCCTGTTGAATCTGA GCTGCAGGTTCCTTATCTGTCACACCTGTGCCTCCTCAGAGGACAGTTTTTTTGTTGTTGTGTTTTTTTGTTTTTTTTTTTTTGGTAGATGCATGACTTG TGTGTGATGAGAGAATGGAGACAGAGTCCCTGGCTCCTCTACTGTTTAACAACATGGCTTTCTTATTTTGTTTGAATTGTTAATTCACAGAATAGCACAA ACTACAATTAAAACTAAGCACAAAGCCATTCTAAGTCATTGGGGAAACGGGGTGAACTTCAGGTGGATGAGGAGACAGAATAGAGTGATAGGAAGCGTCT GGCAGATACTCCTTTTGCCACTGCTGTGTGATTAGACAGGCCCAGTGAGCCGCGGGGCACATGCTGGCCGCTCCTCCCTCAGAAAAAGGCAGTGGCCTAA ATCCTTTTTAAATGACTTGGCTCGATGCTGTGGGGGACTGGCTGGGCTGCTGCAGGCCGTGTGTCTGTCAGCCCAACCTTCACATCTGTCACGTTCTCCA CACGGGGGAGAGACGCAGTCCGCCCAGGTCCCCGCTTTCTTTGGAGGCAGCAGCTCCCGCAGGGCTGAAGTCTGGCGTAAGATGATGGATTTGATTCGCC CTCCTCCCTGTCATAGAGCTGCAGGGTGGATTGTTACAGCTTCGCTGGAAACCTCTGGAGGTCATCTCGGCTGTTCCTGAGAAATAAAAAGCCTGTCATT TCAAACACTGCTGTGGACCCTACTGGGTTTTTAAAATATTGTCAGTTTTTCATCGTCGTCCCTAGCCTGCCAACAGCCATCTGCCCAGACAGCCGCAGTG AGGATGAGCGTCCTGGCAGAGACGCAGTTGTCTCTGGGCGCTTGCCAGAGCCACGAACCCCAGACCTGTTTGTATCATCCGGGCTCCTTCCGGGCAGAAA CAACTGAAAATGCACTTCAGACCCACTTATTTCTGCCACATCTGAGTCGGCCTGAGATAGACTTTTCCCTCTAAACTGGGAGAATATCACAGTGGTTTTT GTTAGCAGAAAATGCACTCCAGCCTCTGTACTCATCTAAGCTGCTTATTTTTGATATTTGTGTCAGTCTGTAAATGGATACTTCACTTTAATAACTGTTG CTTAGTAATTGGCTTTGTAGAGAAGCTGGAAAAAAATGGTTTTGTCTTCAACTCCTTTGCATGCCAGGCGGTGATGTGGATCTCGGCTTCTGTGAGCCTG TGCTGTGGGCAGGGCTGAGCTGGAGCCGCCCCTCTCAGCCCGCCTGCCACGGCCTTTCCTTAAAGGCCATCCTTAAAACCAGACCCTCATGGCTACCAGC ACCTGAAAGCTTCCTCGACATCTGTTAATAAAGCCGTAGGCCCTTGTCTAAGTGCAACCGCCTAGACTTTCTTTCAGATACATGTCCACATGTCCATTTT TCAGGTTCTCTAAGTTGGAGTGGAGTCTGGGAAGGGTTGTGAATGAGGCTTCTGGGCTATGGGTGAGGTTCCAATGGCAGGTTAGAGCCCCTCGGGCCAA CTGCCATCCTGGAAAGTAGAGACAGCAGTGCCCGCTGCCCAGAAGAGACCAGCAAGCCAAACTGGAGCCCCCATTGCAGGCTGTCGCCATGTGGAAAGAG TAACTCACAATTGCCAATAAAGTCTCATGTGGTTTTATCT

primer-1293 (forward primer)
primer-1294 (reverse primer)
Single exon skipping

Frame 0

RLYSQKAAGGGPPKRACAPDMPRGAPLTARFES RDPLAEVAAAAWVPRRCPLPGSPFSRTTASLHSR TGPSWRAAPAPRSGWPRLASSTAPLRTSQTWPS VSSASRSWKAGSQMTTP*RNIKSIRPVALSFLS RSSLKN*PLVNF*NWTEKEPRTKLQRKPTIRRKN LRKLRRKCAVPSSSWLPWIEASGRSCLVPEWLH HFQGLFPGATSLPVGPLAMS*ERRSTFSN*MFQ LCSCFVLKVAPEVLLPVQRVLLVTVAASLSLSLF WGLIFAVLIPGLTR*EVREEEGSVPFARADSFV RVGRAFHSECVWTSCC*GCHSPECGLGRCLLNL SCRFLICHTCASSEDSFFVVVFFCFFFFGRCMTC V**ENGDRVPGSSTV*QHGFLILFELLIHRIAQ TTIKTKHKAILSHWGNGVNFRWMRRQNRVIGSV WQILLLPLLCD*TGPVSRGAHAGRSSLRKRQWPK SFLNDLARCCGGLAGLLQAVCLSAQPSHLSRSP HGGETQSAQVPAFFGGSSSRRAEVWRKMMDLIR PPPCHRAAGWIVTASLETSGGHLGCS*EIKSLSF QTLLWTLLGF*NIVSFSSSSLACQQPSAQTAAV RMSVLAETQLSLGACQSHEPQTCLYHPGSFRAE TTENALQTHLFLPHLSRPEIDFSL*TGRISQWFL LAENALQPLYSSKLLIFDICVSL*MDTSL**LL LSNWLCREAGKKWFCLQLLCMPGGDVDLGFCEP VLWAGLSWSRPSQPACHGLSLKAILKTRPSWLPA PESFLDIC**SRRPLSKCNRLDFLSDTCPHVHF SGSLSWSGVWEGL*MRLLGYG*GSNGRLEPLGP TAILESRDSSARCPEETSKPNWSPHCRLSPCGKS NSQLPIKSHVVLS

Frame 1

ASTPRRPRGVDRLRGRALPTCPAARH*PPDLNR GTRWQRWRRRHGCPDVAPCLAALSQGPPHLYIQ ELALLGGLRLHPGADGRGWLHPLPH*ERARLGPV FLLLQGAGRLGAR*RPHRGT*KAFVRLRFPFCQ EAV*RINPW*IFETGQRKSQEQNCKGNQQ*EER I*GNCGESAPCHRAAGCHGLRPLAGAAWSQSGCT TSRVYSLVPPAFLWAP*QCLRKGDQHFQIRCFN CALVLS*KWHQRCFCLCSGCCW*QWLLLSLSLF FGGSFLLF*FPGLPGEK*GRKKAVSLLLELTALF AWAEPSTVNVSGPHVVEAVTVLSVDLAGAC*I* AAGSLSVTPVPPQRTVFLLLCFFVFFFLVDA*L VCDERMETESLAPLLFNNMAFLFCLNC*FTE*HK LQLKLSTKPF*VIGETG*TSGG*GDRIE**EAS GRYSFCHCCVIRQAQ*AAGHMLAAPPSEKGSGL NPF*MTWLDAVGDWLGCCRPCVCQPNLHICHVLH TGERRSPPRSPLSLEAAAPAGLKSGVR*WI*FA LLPVIELQGGLLQLRWKPLEVISAVPEK*KACH FKHCCGPYWVFKILSVFHRRP*PANSHLPRQPQ* G*ASWQRRSCLWALARATNPRPVCIIRAPSGQK QLKMHFRPTYFCHI*VGLR*TFPSKLGEYHSGF C*QKMHSSLCTHLSCLFLIFVSVCKWILHFNNCC LVIGFVEKLEKNGFVFNSFACQAVMWISASVSL CCGQG*AGAAPLSPPATAFP*RPSLKPDPHGYQ HLKASSTSVNKAVGPCLSATA*TFFQIHVHMSIF QVL*VGVESGKGCE*GFWAMGEVPMAG*SPSGQ LPSWKVETAVPAAQKRPASQTGAPIAGCRHVER VTHNCQ*SLMWFY

Frame 2

PLLPEGRGGWTA*EGVRSRHAPRRAINRQI*IA GPVGRGGGGGMGAPTLPPAWQPFLKDHRISTFK NWPFLEGCACTPERMAEAGFIHCPTENEPDLAQ CFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVK KQFEELTLGEFLKLDRERAKNKIAKETNNKKKE FEETAEKVRRAIEQLAAMD*GLWPELPGPRVAA PLPGFIPWCHQPSCGPLSNVLGKEINIFKLDVST VLLFCLESGTRGASACAAGAAGNSGCFSLSLSF LGAHFCCFDSRAYQVRSEGGRRQCPFC*S*QLC SRGQSLPQ*MCLDLMLLRLSQS*VWTWQVPVESE LQVPYLSHLCLLRGQFFCCCVFLFFFFW*MHDL CVMREWRQSPWLLYCLTTWLSYFV*IVNSQNST NYN*N*AQSHSKSLGKRGELQVDEETE*SDRKRL ADTPFATAV*LDRPSEPRGTCWPLLPQKKAVA* ILFK*LGSMLWGTGWAAAGRVSVSPTFTSVTFS TRGRDAVRPGPRFLWRQQLPQG*SLA*DDGFDSP SSLS*SCRVDCYSFAGNLWRSSRLFLRNKKPVI SNTAVDPTGFLKYCQFFIVVPSLPTAICPDSRS EDERPGRDAVVSGRLPEPRTPDLFVSSGLLPGRN N*KCTSDPLISATSESA*DRLFPLNWENITVVF VSRKCTPASVLI*AAYF*YLCQSVNGYFTLITV A**LAL*RSWKKMVLSSTPLHARR*CGSRLL*AC AVGRAELEPPLSARLPRPFLKGHP*NQTLMATS T*KLPRHLLIKP*ALV*VQPPRLSFRYMSTCPF FRFSKLEWSLGRVVNEASGLWVRFQWQVRAPRAN CHPGK*RQQCPLPRRDQQAKLEPPLQAVAMWKE *LTIANKVSCGFI

Sequence BIRC5.aAug05

CGCCTCTACTCCCAGAAGGCCGCGGGGGGTGGACCGCCTAAGAGGGCGTGCGCTCCCGACATGCCCCGCGGCGCGCCATTAACCGCCAGATTTGAATCGC GGGACCCGTTGGCAGAGGTGGCGGCGGCGGCATGGGTGCCCCGACGTTGCCCCCTGCCTGGCAGCCCTTTCTCAAGGACCACCGCATCTCTACATTCAAG AACTGGCCCTTCTTGGAGGGCTGCGCCTGCACCCCGGAGCGGATGGCCGAGGCTGGCTTCATCCACTGCCCCACTGAGAACGAGCCAGACTTGGCCCAGT GTTTCTTCTGCTTCAAGGAGCTGGAAGGCTGGGAGCCAGATGACGACCCCATTGGGCCGGGCACGGTGGCTTACGCCTGTAATACCAGCACTTTGGGAGG CCGAGGCGGGCGGATCACGAGAGAGGAACATAAAAAGCATTCGTCCGGTTGCGCTTTCCTTTCTGTCAAGAAGCAGTTTGAAGAATTAACCCTTGGTGAA TTTTTGAAACTGGACAGAGAAAGAGCCAAGAACAAAATTGCAAAGGAAACCAACAATAAGAAGAAAGAATTTGAGGAAACTGCGGAGAAAGTGCGCCGTG CCATCGAGCAGCTGGCTGCCATGGATTGAGGCCTCTGGCCGGAGCTGCCTGGTCCCAGAGTGGCTGCACCACTTCCAGGGTTTATTCCCTGGTGCCACCA GCCTTCCTGTGGGCCCCTTAGCAATGTCTTAGGAAAGGAGATCAACATTTTCAAATTAGATGTTTCAACTGTGCTCTTGTTTTGTCTTGAAAGTGGCACC AGAGGTGCTTCTGCCTGTGCAGCGGGTGCTGCTGGTAACAGTGGCTGCTTCTCTCTCTCTCTCTCTTTTTTGGGGGCTCATTTTTGCTGTTTTGATTCCC GGGCTTACCAGGTGAGAAGTGAGGGAGGAAGAAGGCAGTGTCCCTTTTGCTAGAGCTGACAGCTTTGTTCGCGTGGGCAGAGCCTTCCACAGTGAATGTG TCTGGACCTCATGTTGTTGAGGCTGTCACAGTCCTGAGTGTGGACTTGGCAGGTGCCTGTTGAATCTGAGCTGCAGGTTCCTTATCTGTCACACCTGTGC CTCCTCAGAGGACAGTTTTTTTGTTGTTGTGTTTTTTTGTTTTTTTTTTTTTGGTAGATGCATGACTTGTGTGTGATGAGAGAATGGAGACAGAGTCCCT GGCTCCTCTACTGTTTAACAACATGGCTTTCTTATTTTGTTTGAATTGTTAATTCACAGAATAGCACAAACTACAATTAAAACTAAGCACAAAGCCATTC TAAGTCATTGGGGAAACGGGGTGAACTTCAGGTGGATGAGGAGACAGAATAGAGTGATAGGAAGCGTCTGGCAGATACTCCTTTTGCCACTGCTGTGTGA TTAGACAGGCCCAGTGAGCCGCGGGGCACATGCTGGCCGCTCCTCCCTCAGAAAAAGGCAGTGGCCTAAATCCTTTTTAAATGACTTGGCTCGATGCTGT GGGGGACTGGCTGGGCTGCTGCAGGCCGTGTGTCTGTCAGCCCAACCTTCACATCTGTCACGTTCTCCACACGGGGGAGAGACGCAGTCCGCCCAGGTCC CCGCTTTCTTTGGAGGCAGCAGCTCCCGCAGGGCTGAAGTCTGGCGTAAGATGATGGATTTGATTCGCCCTCCTCCCTGTCATAGAGCTGCAGGGTGGAT TGTTACAGCTTCGCTGGAAACCTCTGGAGGTCATCTCGGCTGTTCCTGAGAAATAAAAAGCCTGTCATTTCAAACACTGCTGTGGACCCTACTGGGTTTT TAAAATATTGTCAGTTTTTCATCGTCGTCCCTAGCCTGCCAACAGCCATCTGCCCAGACAGCCGCAGTGAGGATGAGCGTCCTGGCAGAGACGCAGTTGT CTCTGGGCGCTTGCCAGAGCCACGAACCCCAGACCTGTTTGTATCATCCGGGCTCCTTCCGGGCAGAAACAACTGAAAATGCACTTCAGACCCACTTATT TCTGCCACATCTGAGTCGGCCTGAGATAGACTTTTCCCTCTAAACTGGGAGAATATCACAGTGGTTTTTGTTAGCAGAAAATGCACTCCAGCCTCTGTAC TCATCTAAGCTGCTTATTTTTGATATTTGTGTCAGTCTGTAAATGGATACTTCACTTTAATAACTGTTGCTTAGTAATTGGCTTTGTAGAGAAGCTGGAA AAAAATGGTTTTGTCTTCAACTCCTTTGCATGCCAGGCGGTGATGTGGATCTCGGCTTCTGTGAGCCTGTGCTGTGGGCAGGGCTGAGCTGGAGCCGCCC CTCTCAGCCCGCCTGCCACGGCCTTTCCTTAAAGGCCATCCTTAAAACCAGACCCTCATGGCTACCAGCACCTGAAAGCTTCCTCGACATCTGTTAATAA AGCCGTAGGCCCTTGTCTAAGTGCAACCGCCTAGACTTTCTTTCAGATACATGTCCACATGTCCATTTTTCAGGTTCTCTAAGTTGGAGTGGAGTCTGGG AAGGGTTGTGAATGAGGCTTCTGGGCTATGGGTGAGGTTCCAATGGCAGGTTAGAGCCCCTCGGGCCAACTGCCATCCTGGAAAGTAGAGACAGCAGTGC CCGCTGCCCAGAAGAGACCAGCAAGCCAAACTGGAGCCCCCATTGCAGGCTGTCGCCATGTGGAAAGAGTAACTCACAATTGCCAATAAAGTCTCATGTG GTTTTATCT

primer-1293 (forward primer)
primer-1294 (reverse primer)
Single exon skipping

Frame 0

RLYSQKAAGGGPPKRACAPDMPRGAPLTARFES RDPLAEVAAAAWVPRRCPLPGSPFSRTTASLHSR TGPSWRAAPAPRSGWPRLASSTAPLRTSQTWPS VSSASRSWKAGSQMTTPLGRARWLTPVIPALWE AEAGGSRERNIKSIRPVALSFLSRSSLKN*PLVN F*NWTEKEPRTKLQRKPTIRRKNLRKLRRKCAV PSSSWLPWIEASGRSCLVPEWLHHFQGLFPGAT SLPVGPLAMS*ERRSTFSN*MFQLCSCFVLKVAP EVLLPVQRVLLVTVAASLSLSLFWGLIFAVLIP GLTR*EVREEEGSVPFARADSFVRVGRAFHSEC VWTSCC*GCHSPECGLGRCLLNLSCRFLICHTCA SSEDSFFVVVFFCFFFFGRCMTCV**ENGDRVP GSSTV*QHGFLILFELLIHRIAQTTIKTKHKAI LSHWGNGVNFRWMRRQNRVIGSVWQILLLPLLCD *TGPVSRGAHAGRSSLRKRQWPKSFLNDLARCC GGLAGLLQAVCLSAQPSHLSRSPHGGETQSAQV PAFFGGSSSRRAEVWRKMMDLIRPPPCHRAAGWI VTASLETSGGHLGCS*EIKSLSFQTLLWTLLGF *NIVSFSSSSLACQQPSAQTAAVRMSVLAETQL SLGACQSHEPQTCLYHPGSFRAETTENALQTHLF LPHLSRPEIDFSL*TGRISQWFLLAENALQPLY SSKLLIFDICVSL*MDTSL**LLLSNWLCREAG KKWFCLQLLCMPGGDVDLGFCEPVLWAGLSWSRP SQPACHGLSLKAILKTRPSWLPAPESFLDIC** SRRPLSKCNRLDFLSDTCPHVHFSGSLSWSGVW EGL*MRLLGYG*GSNGRLEPLGPTAILESRDSSA RCPEETSKPNWSPHCRLSPCGKSNSQLPIKSHV VLS

Frame 1

ASTPRRPRGVDRLRGRALPTCPAARH*PPDLNR GTRWQRWRRRHGCPDVAPCLAALSQGPPHLYIQ ELALLGGLRLHPGADGRGWLHPLPH*ERARLGPV FLLLQGAGRLGAR*RPHWAGHGGLRL*YQHFGR PRRADHERGT*KAFVRLRFPFCQEAV*RINPW* IFETGQRKSQEQNCKGNQQ*EERI*GNCGESAPC HRAAGCHGLRPLAGAAWSQSGCTTSRVYSLVPP AFLWAP*QCLRKGDQHFQIRCFNCALVLS*KWH QRCFCLCSGCCW*QWLLLSLSLFFGGSFLLF*FP GLPGEK*GRKKAVSLLLELTALFAWAEPSTVNV SGPHVVEAVTVLSVDLAGAC*I*AAGSLSVTPV PPQRTVFLLLCFFVFFFLVDA*LVCDERMETESL APLLFNNMAFLFCLNC*FTE*HKLQLKLSTKPF *VIGETG*TSGG*GDRIE**EASGRYSFCHCCV IRQAQ*AAGHMLAAPPSEKGSGLNPF*MTWLDAV GDWLGCCRPCVCQPNLHICHVLHTGERRSPPRS PLSLEAAAPAGLKSGVR*WI*FALLPVIELQGG LLQLRWKPLEVISAVPEK*KACHFKHCCGPYWVF KILSVFHRRP*PANSHLPRQPQ*G*ASWQRRSC LWALARATNPRPVCIIRAPSGQKQLKMHFRPTY FCHI*VGLR*TFPSKLGEYHSGFC*QKMHSSLCT HLSCLFLIFVSVCKWILHFNNCCLVIGFVEKLE KNGFVFNSFACQAVMWISASVSLCCGQG*AGAA PLSPPATAFP*RPSLKPDPHGYQHLKASSTSVNK AVGPCLSATA*TFFQIHVHMSIFQVL*VGVESG KGCE*GFWAMGEVPMAG*SPSGQLPSWKVETAV PAAQKRPASQTGAPIAGCRHVERVTHNCQ*SLMW FY

Frame 2

PLLPEGRGGWTA*EGVRSRHAPRRAINRQI*IA GPVGRGGGGGMGAPTLPPAWQPFLKDHRISTFK NWPFLEGCACTPERMAEAGFIHCPTENEPDLAQ CFFCFKELEGWEPDDDPIGPGTVAYACNTSTLGG RGGRITREEHKKHSSGCAFLSVKKQFEELTLGE FLKLDRERAKNKIAKETNNKKKEFEETAEKVRR AIEQLAAMD*GLWPELPGPRVAAPLPGFIPWCHQ PSCGPLSNVLGKEINIFKLDVSTVLLFCLESGT RGASACAAGAAGNSGCFSLSLSFLGAHFCCFDS RAYQVRSEGGRRQCPFC*S*QLCSRGQSLPQ*MC LDLMLLRLSQS*VWTWQVPVESELQVPYLSHLC LLRGQFFCCCVFLFFFFW*MHDLCVMREWRQSP WLLYCLTTWLSYFV*IVNSQNSTNYN*N*AQSHS KSLGKRGELQVDEETE*SDRKRLADTPFATAV* LDRPSEPRGTCWPLLPQKKAVA*ILFK*LGSML WGTGWAAAGRVSVSPTFTSVTFSTRGRDAVRPGP RFLWRQQLPQG*SLA*DDGFDSPSSLS*SCRVD CYSFAGNLWRSSRLFLRNKKPVISNTAVDPTGF LKYCQFFIVVPSLPTAICPDSRSEDERPGRDAVV SGRLPEPRTPDLFVSSGLLPGRNN*KCTSDPLI SATSESA*DRLFPLNWENITVVFVSRKCTPASV LI*AAYF*YLCQSVNGYFTLITVA**LAL*RSWK KMVLSSTPLHARR*CGSRLL*ACAVGRAELEPP LSARLPRPFLKGHP*NQTLMATST*KLPRHLLI KP*ALV*VQPPRLSFRYMSTCPFFRFSKLEWSLG RVVNEASGLWVRFQWQVRAPRANCHPGK*RQQC PLPRRDQQAKLEPPLQAVAMWKE*LTIANKVSC GFI